-- dump date 20140620_055119 -- class Genbank::misc_feature -- table misc_feature_note -- id note 568708000002 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 568708000003 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 568708000004 putative catalytic residues [active] 568708000005 putative nucleotide binding site [chemical binding]; other site 568708000006 putative aspartate binding site [chemical binding]; other site 568708000007 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 568708000008 dimer interface [polypeptide binding]; other site 568708000009 putative threonine allosteric regulatory site; other site 568708000010 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 568708000011 putative threonine allosteric regulatory site; other site 568708000012 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 568708000013 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 568708000018 homoserine kinase; Provisional; Region: PRK01212 568708000019 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568708000022 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 568708000023 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 568708000024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708000025 catalytic residue [active] 568708000027 hypothetical protein; Validated; Region: PRK02101 568708000029 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 568708000030 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 568708000031 9 probable transmembrane helices predicted for STM_MW00051 by TMHMM2.0 at aa 13-35, 75-97, 136-158, 171-193, 203-225, 301-323, 343-365, 386-408 and 413-435 568708000033 transaldolase-like protein; Provisional; Region: PTZ00411 568708000034 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 568708000035 active site 568708000036 dimer interface [polypeptide binding]; other site 568708000037 catalytic residue [active] 568708000039 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 568708000040 MPT binding site; other site 568708000041 trimer interface [polypeptide binding]; other site 568708000043 hypothetical protein; Provisional; Region: PRK10659 568708000045 6 probable transmembrane helices predicted for STM_MW00081 by TMHMM2.0 at aa 12-34, 38-57, 64-86, 96-118, 125-144 and 148-170 568708000046 hypothetical protein; Provisional; Region: PRK10236 568708000047 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 568708000048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 568708000050 Protein of unknown function (DUF2541); Region: DUF2541; pfam10807 568708000052 Signal peptide predicted for STM_MW00101 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.944 between residues 23 and 24 568708000053 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 568708000054 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 568708000055 nucleotide binding site [chemical binding]; other site 568708000057 chaperone protein DnaJ; Provisional; Region: PRK10767 568708000058 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568708000059 HSP70 interaction site [polypeptide binding]; other site 568708000060 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 568708000061 substrate binding site [polypeptide binding]; other site 568708000062 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 568708000063 Zn binding sites [ion binding]; other site 568708000064 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 568708000065 dimer interface [polypeptide binding]; other site 568708000069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708000070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708000071 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568708000072 dimerization interface [polypeptide binding]; other site 568708000074 3 probable transmembrane helices predicted for STM_MW00141 by TMHMM2.0 at aa 15-37, 50-72 and 82-101 568708000075 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 568708000076 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 568708000077 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 568708000080 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 568708000081 1 probable transmembrane helix predicted for STM_MW00161 by TMHMM2.0 at aa 127-146 568708000082 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 568708000083 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 568708000084 active site 568708000085 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 568708000086 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 568708000087 aromatic chitin/cellulose binding site residues [chemical binding]; other site 568708000090 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568708000091 Helix-turn-helix domain; Region: HTH_36; pfam13730 568708000092 fimbrial protein BcfA; Provisional; Region: PRK15187 568708000093 Signal peptide predicted for STM_MW00201 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 24 and 25 568708000095 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 568708000096 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708000097 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708000098 Signal peptide predicted for STM_MW00211 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.937 between residues 26 and 27 568708000099 1 probable transmembrane helix predicted for STM_MW00211 by TMHMM2.0 at aa 7-29 568708000102 outer membrane usher protein; Provisional; Region: PRK15193 568708000103 PapC N-terminal domain; Region: PapC_N; pfam13954 568708000104 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568708000105 PapC C-terminal domain; Region: PapC_C; pfam13953 568708000106 Signal peptide predicted for STM_MW00221 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 35 and 36 568708000108 fimbrial protein BcfD; Provisional; Region: PRK15189 568708000109 Signal peptide predicted for STM_MW00231 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 21 and 22 568708000111 fimbrial protein BcfE; Provisional; Region: PRK15190 568708000112 Signal peptide predicted for STM_MW00241 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.758 between residues 23 and 24 568708000114 fimbrial protein BcfF; Provisional; Region: PRK15191 568708000115 Signal peptide predicted for STM_MW00251 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.997 between residues 20 and 21 568708000117 fimbrial chaperone BcfG; Provisional; Region: PRK15192 568708000118 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708000119 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708000120 1 probable transmembrane helix predicted for STM_MW00261 by TMHMM2.0 at aa 13-35 568708000123 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 568708000124 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 568708000125 catalytic residues [active] 568708000126 Signal peptide predicted for STM_MW00271 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 27 and 28 568708000128 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 568708000129 1 probable transmembrane helix predicted for STM_MW00291 by TMHMM2.0 at aa 128-147 568708000131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708000132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708000133 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568708000135 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 568708000136 1 probable transmembrane helix predicted for STM_MW00311 by TMHMM2.0 at aa 128-145 568708000138 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 568708000140 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 568708000141 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 568708000142 active site 568708000143 metal binding site [ion binding]; metal-binding site 568708000144 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 568708000147 Signal peptide predicted for STM_MW00341 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.798 between residues 29 and 30 568708000148 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 568708000150 Signal peptide predicted for STM_MW00351 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 24 and 25 568708000151 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 568708000152 Sulfatase; Region: Sulfatase; pfam00884 568708000153 Signal peptide predicted for STM_MW00361 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.916 between residues 25 and 26 568708000154 1 probable transmembrane helix predicted for STM_MW00361 by TMHMM2.0 at aa 5-27 568708000156 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 568708000157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708000158 FeS/SAM binding site; other site 568708000159 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 568708000161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 568708000163 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 568708000165 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 568708000166 Signal peptide predicted for STM_MW00401 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.378 between residues 35 and 36 568708000168 11 probable transmembrane helices predicted for STM_MW00401 by TMHMM2.0 at aa 7-29, 59-76, 96-115, 125-147, 154-176, 180-202, 215-237, 257-279, 291-313, 328-350 and 357-379 568708000169 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 568708000170 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708000171 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 568708000172 putative dimerization interface [polypeptide binding]; other site 568708000175 putative alpha-glucosidase; Provisional; Region: PRK10658 568708000176 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 568708000177 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 568708000178 putative active site [active] 568708000179 putative catalytic site [active] 568708000181 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 568708000182 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 568708000183 11 probable transmembrane helices predicted for STM_MW00431 by TMHMM2.0 at aa 42-64, 92-109, 124-146, 167-184, 189-211, 240-257, 277-299, 306-326, 336-358, 371-396 and 416-438 568708000185 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 568708000187 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 568708000189 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 568708000190 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 568708000191 active site 568708000192 Riboflavin kinase; Region: Flavokinase; smart00904 568708000195 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 568708000196 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568708000197 active site 568708000198 HIGH motif; other site 568708000199 nucleotide binding site [chemical binding]; other site 568708000200 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 568708000201 active site 568708000202 KMSKS motif; other site 568708000203 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 568708000204 tRNA binding surface [nucleotide binding]; other site 568708000205 anticodon binding site; other site 568708000206 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568708000210 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 568708000211 4 probable transmembrane helices predicted for STM_MW00481 by TMHMM2.0 at aa 13-35, 67-86, 99-121 and 136-158 568708000213 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 568708000214 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 568708000216 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 568708000217 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 568708000219 Signal peptide predicted for STM_MW00511 by SignalP 2.0 HMM (Signal peptide probability 0.625) with cleavage site probability 0.364 between residues 22 and 23 568708000220 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 568708000221 active site 568708000222 tetramer interface [polypeptide binding]; other site 568708000224 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 568708000225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708000226 active site 568708000227 phosphorylation site [posttranslational modification] 568708000228 intermolecular recognition site; other site 568708000229 dimerization interface [polypeptide binding]; other site 568708000230 Transcriptional regulator; Region: CitT; pfam12431 568708000232 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 568708000233 PAS domain; Region: PAS; smart00091 568708000234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708000235 ATP binding site [chemical binding]; other site 568708000236 Mg2+ binding site [ion binding]; other site 568708000237 G-X-G motif; other site 568708000238 2 probable transmembrane helices predicted for STM_MW00541 by TMHMM2.0 at aa 20-39 and 173-195 568708000240 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 568708000241 9 probable transmembrane helices predicted for STM_MW00551 by TMHMM2.0 at aa 13-35, 42-64, 125-147, 160-182, 214-236, 266-288, 308-327, 339-361 and 409-431 568708000243 oxaloacetate decarboxylase; Provisional; Region: PRK14040 568708000244 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 568708000245 active site 568708000246 catalytic residues [active] 568708000247 metal binding site [ion binding]; metal-binding site 568708000248 homodimer binding site [polypeptide binding]; other site 568708000249 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568708000250 carboxyltransferase (CT) interaction site; other site 568708000251 biotinylation site [posttranslational modification]; other site 568708000255 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 568708000257 1 probable transmembrane helix predicted for STM_MW00571 by TMHMM2.0 at aa 10-32 568708000258 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 568708000259 12 probable transmembrane helices predicted for STM_MW00581 by TMHMM2.0 at aa 23-45, 52-69, 79-101, 114-132, 147-169, 176-198, 208-230, 269-286, 296-318, 331-348, 363-385 and 425-444 568708000261 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 568708000262 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 568708000263 putative active site [active] 568708000264 (T/H)XGH motif; other site 568708000266 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 568708000268 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 568708000269 Signal peptide predicted for STM_MW00611 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.975 between residues 25 and 26 568708000271 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 568708000272 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 568708000274 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 568708000276 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 568708000278 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 568708000279 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 568708000280 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 568708000283 tmhmm; query 1-116 568708000284 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 568708000285 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 568708000286 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 568708000287 catalytic site [active] 568708000288 subunit interface [polypeptide binding]; other site 568708000291 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 568708000292 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568708000293 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568708000294 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 568708000295 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568708000296 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568708000297 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 568708000298 IMP binding site; other site 568708000299 dimer interface [polypeptide binding]; other site 568708000300 interdomain contacts; other site 568708000301 partial ornithine binding site; other site 568708000302 Signal peptide predicted for STM_MW00691 by SignalP 2.0 HMM (Signal peptide probability 0.643) with cleavage site probability 0.569 between residues 23 and 24 568708000307 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 568708000309 carnitine operon protein CaiE; Provisional; Region: PRK13627 568708000310 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 568708000311 putative trimer interface [polypeptide binding]; other site 568708000312 putative metal binding site [ion binding]; other site 568708000314 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 568708000315 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568708000316 substrate binding site [chemical binding]; other site 568708000317 oxyanion hole (OAH) forming residues; other site 568708000318 trimer interface [polypeptide binding]; other site 568708000320 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 568708000321 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 568708000322 acyl-activating enzyme (AAE) consensus motif; other site 568708000323 putative AMP binding site [chemical binding]; other site 568708000324 putative active site [active] 568708000325 putative CoA binding site [chemical binding]; other site 568708000327 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 568708000328 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568708000330 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 568708000331 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 568708000332 active site 568708000336 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 568708000337 12 probable transmembrane helices predicted for STM_MW00761 by TMHMM2.0 at aa 13-30, 50-72, 92-114, 144-163, 195-214, 229-251, 264-286, 312-334, 347-366, 410-432, 445-467 and 472-494 568708000339 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 568708000340 Ligand binding site [chemical binding]; other site 568708000341 Electron transfer flavoprotein domain; Region: ETF; pfam01012 568708000343 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 568708000344 Electron transfer flavoprotein domain; Region: ETF; smart00893 568708000345 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 568708000348 putative oxidoreductase FixC; Provisional; Region: PRK10157 568708000350 ferredoxin-like protein FixX; Provisional; Region: PRK15449 568708000351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708000352 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 568708000353 putative substrate translocation pore; other site 568708000354 11 probable transmembrane helices predicted for STM_MW00811 by TMHMM2.0 at aa 47-69, 82-104, 113-132, 137-159, 172-194, 199-221, 272-294, 309-331, 352-374, 400-422 and 427-449 568708000356 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 568708000357 Signal peptide predicted for STM_MW00821 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.786 between residues 37 and 38 568708000359 Signal peptide predicted for STM_MW00841 by SignalP 2.0 HMM (Signal peptide probability 0.955) with cleavage site probability 0.672 between residues 18 and 19 568708000360 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 568708000362 Signal peptide predicted for STM_MW00851 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 21 and 22 568708000364 1 probable transmembrane helix predicted for STM_MW00871 by TMHMM2.0 at aa 25-47 568708000365 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 568708000366 Sulfatase; Region: Sulfatase; cl17466 568708000367 Sulfatase; Region: Sulfatase; cl17466 568708000368 Sulfatase; Region: Sulfatase; cl17466 568708000369 Signal peptide predicted for STM_MW00881 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.874 between residues 38 and 39 568708000372 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 568708000374 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 568708000375 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 568708000376 TrkA-N domain; Region: TrkA_N; pfam02254 568708000377 13 probable transmembrane helices predicted for STM_MW00911 by TMHMM2.0 at aa 5-24, 26-45, 55-74, 86-108, 112-134, 147-169, 179-201, 214-233, 237-254, 267-289, 293-315, 327-349 and 359-378 568708000380 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 568708000381 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 568708000382 folate binding site [chemical binding]; other site 568708000383 NADP+ binding site [chemical binding]; other site 568708000385 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 568708000386 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 568708000387 active site 568708000388 metal binding site [ion binding]; metal-binding site 568708000390 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 568708000392 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 568708000393 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 568708000395 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 568708000396 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 568708000398 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 568708000399 SurA N-terminal domain; Region: SurA_N; pfam09312 568708000400 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568708000401 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568708000404 Signal peptide predicted for STM_MW00971 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 568708000405 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 568708000406 OstA-like protein; Region: OstA; pfam03968 568708000407 Organic solvent tolerance protein; Region: OstA_C; pfam04453 568708000410 Signal peptide predicted for STM_MW00981 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 24 and 25 568708000411 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 568708000412 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 568708000413 putative metal binding site [ion binding]; other site 568708000414 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568708000415 HSP70 interaction site [polypeptide binding]; other site 568708000416 1 probable transmembrane helix predicted for STM_MW00991 by TMHMM2.0 at aa 7-29 568708000419 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568708000420 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568708000421 active site 568708000423 ATP-dependent helicase HepA; Validated; Region: PRK04914 568708000424 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568708000425 ATP binding site [chemical binding]; other site 568708000426 putative Mg++ binding site [ion binding]; other site 568708000427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708000428 nucleotide binding region [chemical binding]; other site 568708000429 ATP-binding site [chemical binding]; other site 568708000432 DNA polymerase II; Reviewed; Region: PRK05762 568708000433 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 568708000434 active site 568708000435 catalytic site [active] 568708000436 substrate binding site [chemical binding]; other site 568708000437 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 568708000438 active site 568708000439 metal-binding site 568708000442 Uncharacterized conserved protein [Function unknown]; Region: COG1434 568708000443 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568708000444 putative active site [active] 568708000446 Signal peptide predicted for STM_MW01031 by SignalP 2.0 HMM (Signal peptide probability 0.907) with cleavage site probability 0.613 between residues 27 and 28 568708000447 1 probable transmembrane helix predicted for STM_MW01031 by TMHMM2.0 at aa 5-27 568708000449 1 probable transmembrane helix predicted for STM_MW01051 by TMHMM2.0 at aa 52-74 568708000450 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 568708000451 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 568708000452 intersubunit interface [polypeptide binding]; other site 568708000453 active site 568708000454 Zn2+ binding site [ion binding]; other site 568708000456 L-arabinose isomerase; Provisional; Region: PRK02929 568708000457 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 568708000458 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 568708000459 trimer interface [polypeptide binding]; other site 568708000460 putative substrate binding site [chemical binding]; other site 568708000461 putative metal binding site [ion binding]; other site 568708000464 ribulokinase; Provisional; Region: PRK04123 568708000465 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 568708000466 N- and C-terminal domain interface [polypeptide binding]; other site 568708000467 active site 568708000468 MgATP binding site [chemical binding]; other site 568708000469 catalytic site [active] 568708000470 metal binding site [ion binding]; metal-binding site 568708000471 carbohydrate binding site [chemical binding]; other site 568708000472 homodimer interface [polypeptide binding]; other site 568708000475 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 568708000476 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 568708000477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708000478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708000481 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568708000482 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 568708000483 5 probable transmembrane helices predicted for STM_MW01111 by TMHMM2.0 at aa 13-35, 57-79, 140-162, 177-199 and 219-241 568708000485 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 568708000486 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 568708000487 Walker A/P-loop; other site 568708000488 ATP binding site [chemical binding]; other site 568708000489 Q-loop/lid; other site 568708000490 ABC transporter signature motif; other site 568708000491 Walker B; other site 568708000492 D-loop; other site 568708000493 H-loop/switch region; other site 568708000495 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 568708000496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708000497 dimer interface [polypeptide binding]; other site 568708000498 conserved gate region; other site 568708000499 putative PBP binding loops; other site 568708000500 ABC-ATPase subunit interface; other site 568708000501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708000502 dimer interface [polypeptide binding]; other site 568708000503 conserved gate region; other site 568708000504 putative PBP binding loops; other site 568708000505 ABC-ATPase subunit interface; other site 568708000506 12 probable transmembrane helices predicted for STM_MW01131 by TMHMM2.0 at aa 13-35, 55-77, 90-112, 127-149, 199-221, 241-260, 293-315, 335-357, 370-392, 407-424, 462-484 and 508-525 568708000508 Signal peptide predicted for STM_MW01131 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.574 between residues 29 and 30 568708000509 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 568708000510 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 568708000512 Signal peptide predicted for STM_MW01141 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19 568708000513 transcriptional regulator SgrR; Provisional; Region: PRK13626 568708000514 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 568708000515 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 568708000517 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 568708000518 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 568708000519 substrate binding site [chemical binding]; other site 568708000521 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 568708000522 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 568708000523 substrate binding site [chemical binding]; other site 568708000524 ligand binding site [chemical binding]; other site 568708000526 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 568708000527 tartrate dehydrogenase; Region: TTC; TIGR02089 568708000529 2-isopropylmalate synthase; Validated; Region: PRK00915 568708000530 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 568708000531 active site 568708000532 catalytic residues [active] 568708000533 metal binding site [ion binding]; metal-binding site 568708000534 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 568708000537 leu operon leader peptide; Provisional; Region: PRK14744 568708000539 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 568708000540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708000541 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 568708000542 putative substrate binding pocket [chemical binding]; other site 568708000543 putative dimerization interface [polypeptide binding]; other site 568708000546 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 568708000547 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568708000548 dimer interface [polypeptide binding]; other site 568708000549 PYR/PP interface [polypeptide binding]; other site 568708000550 TPP binding site [chemical binding]; other site 568708000551 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568708000552 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 568708000553 TPP-binding site [chemical binding]; other site 568708000554 dimer interface [polypeptide binding]; other site 568708000558 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 568708000559 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 568708000560 putative valine binding site [chemical binding]; other site 568708000561 dimer interface [polypeptide binding]; other site 568708000562 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 568708000565 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 568708000566 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708000567 DNA binding site [nucleotide binding] 568708000568 domain linker motif; other site 568708000569 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 568708000570 dimerization interface [polypeptide binding]; other site 568708000571 ligand binding site [chemical binding]; other site 568708000574 mraZ protein; Region: TIGR00242 568708000575 MraZ protein; Region: MraZ; pfam02381 568708000576 MraZ protein; Region: MraZ; pfam02381 568708000578 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 568708000579 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 568708000581 cell division protein FtsL; Provisional; Region: PRK10772 568708000583 1 probable transmembrane helix predicted for STM_MW01271 by TMHMM2.0 at aa 35-57 568708000584 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 568708000585 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568708000586 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568708000587 Signal peptide predicted for STM_MW01281 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.824 between residues 42 and 43 568708000588 1 probable transmembrane helix predicted for STM_MW01281 by TMHMM2.0 at aa 21-43 568708000591 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 568708000592 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568708000593 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568708000594 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568708000598 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 568708000599 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568708000600 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568708000601 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568708000605 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 568708000606 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 568708000607 Mg++ binding site [ion binding]; other site 568708000608 putative catalytic motif [active] 568708000609 putative substrate binding site [chemical binding]; other site 568708000610 10 probable transmembrane helices predicted for STM_MW01311 by TMHMM2.0 at aa 15-37, 75-92, 97-114, 134-151, 171-193, 200-219, 234-256, 263-285, 289-311 and 338-357 568708000613 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 568708000614 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568708000615 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568708000616 1 probable transmembrane helix predicted for STM_MW01321 by TMHMM2.0 at aa 9-31 568708000619 cell division protein FtsW; Provisional; Region: PRK10774 568708000621 8 probable transmembrane helices predicted for STM_MW01331 by TMHMM2.0 at aa 20-42, 57-74, 81-103, 155-177, 190-212, 278-300, 312-334 and 344-366 568708000622 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 568708000623 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 568708000624 active site 568708000625 homodimer interface [polypeptide binding]; other site 568708000626 Signal peptide predicted for STM_MW01341 by SignalP 2.0 HMM (Signal peptide probability 0.680) with cleavage site probability 0.584 between residues 26 and 27 568708000629 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 568708000630 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568708000631 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568708000632 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568708000636 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 568708000637 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 568708000638 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 568708000641 cell division protein FtsQ; Provisional; Region: PRK10775 568708000642 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 568708000643 Cell division protein FtsQ; Region: FtsQ; pfam03799 568708000644 1 probable transmembrane helix predicted for STM_MW01371 by TMHMM2.0 at aa 26-48 568708000647 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 568708000648 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568708000649 Cell division protein FtsA; Region: FtsA; pfam14450 568708000651 cell division protein FtsZ; Validated; Region: PRK09330 568708000652 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 568708000653 nucleotide binding site [chemical binding]; other site 568708000654 SulA interaction site; other site 568708000655 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 568708000658 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 568708000659 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 568708000661 SecA regulator SecM; Provisional; Region: PRK02943 568708000663 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 568708000664 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 568708000665 SEC-C motif; Region: SEC-C; pfam02810 568708000670 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 568708000671 active site 568708000672 8-oxo-dGMP binding site [chemical binding]; other site 568708000673 nudix motif; other site 568708000674 metal binding site [ion binding]; metal-binding site 568708000676 DNA gyrase inhibitor; Reviewed; Region: PRK00418 568708000678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 568708000680 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 568708000681 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 568708000682 CoA-binding site [chemical binding]; other site 568708000683 ATP-binding [chemical binding]; other site 568708000685 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 568708000686 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 568708000687 active site 568708000689 type IV pilin biogenesis protein; Provisional; Region: PRK10573 568708000690 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 568708000691 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 568708000692 3 probable transmembrane helices predicted for STM_MW01481 by TMHMM2.0 at aa 163-185, 205-227 and 368-390 568708000694 hypothetical protein; Provisional; Region: PRK10436 568708000695 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 568708000696 Walker A motif; other site 568708000697 ATP binding site [chemical binding]; other site 568708000698 Walker B motif; other site 568708000701 putative major pilin subunit; Provisional; Region: PRK10574 568708000702 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 568708000703 Pilin (bacterial filament); Region: Pilin; pfam00114 568708000706 1 probable transmembrane helix predicted for STM_MW01501 by TMHMM2.0 at aa 7-29 568708000707 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 568708000708 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 568708000709 dimerization interface [polypeptide binding]; other site 568708000710 active site 568708000713 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 568708000714 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 568708000715 amidase catalytic site [active] 568708000716 Zn binding residues [ion binding]; other site 568708000717 substrate binding site [chemical binding]; other site 568708000719 regulatory protein AmpE; Provisional; Region: PRK10987 568708000721 4 probable transmembrane helices predicted for STM_MW01531 by TMHMM2.0 at aa 36-58, 63-85, 146-168 and 266-283 568708000722 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 568708000723 active site 568708000725 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 568708000726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708000727 putative substrate translocation pore; other site 568708000729 12 probable transmembrane helices predicted for STM_MW01551 by TMHMM2.0 at aa 12-31, 35-57, 81-100, 115-137, 150-172, 182-204, 234-256, 266-288, 295-317, 322-344, 365-387 and 407-429 568708000730 aromatic amino acid transporter; Provisional; Region: PRK10238 568708000731 12 probable transmembrane helices predicted for STM_MW01561 by TMHMM2.0 at aa 20-42, 47-66, 87-109, 119-141, 154-176, 199-221, 241-263, 283-305, 332-354, 358-380, 400-422 and 427-446 568708000733 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 568708000734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708000735 DNA-binding site [nucleotide binding]; DNA binding site 568708000736 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568708000739 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 568708000740 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 568708000741 dimer interface [polypeptide binding]; other site 568708000742 TPP-binding site [chemical binding]; other site 568708000744 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 568708000745 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568708000746 E3 interaction surface; other site 568708000747 lipoyl attachment site [posttranslational modification]; other site 568708000748 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568708000749 E3 interaction surface; other site 568708000750 lipoyl attachment site [posttranslational modification]; other site 568708000751 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568708000752 E3 interaction surface; other site 568708000753 lipoyl attachment site [posttranslational modification]; other site 568708000754 e3 binding domain; Region: E3_binding; pfam02817 568708000755 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 568708000759 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 568708000760 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568708000761 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568708000762 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568708000766 Signal peptide predicted for STM_MW01611 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 568708000767 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 568708000769 Signal peptide predicted for STM_MW01621 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.964 between residues 19 and 20 568708000770 pfam_scan;Pfam:PF11737; E()=1.0E-78;score=263.2;query 59-303;description=DUF3300 568708000772 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 568708000773 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 568708000774 substrate binding site [chemical binding]; other site 568708000775 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 568708000776 substrate binding site [chemical binding]; other site 568708000777 ligand binding site [chemical binding]; other site 568708000781 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 568708000782 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 568708000783 hypothetical protein; Provisional; Region: PRK05248 568708000785 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 568708000787 10 probable transmembrane helices predicted for STM_MW01671 by TMHMM2.0 at aa 13-35, 45-64, 71-90, 100-122, 134-156, 160-182, 189-211, 215-237, 244-266 and 281-303 568708000788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 568708000790 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 568708000791 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 568708000793 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568708000794 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568708000795 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708000798 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 568708000800 spermidine synthase; Provisional; Region: PRK00811 568708000801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708000802 S-adenosylmethionine binding site [chemical binding]; other site 568708000804 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 568708000806 Signal peptide predicted for STM_MW01731 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.745 between residues 22 and 23 568708000807 multicopper oxidase; Provisional; Region: PRK10965 568708000808 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 568708000809 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 568708000810 Signal peptide predicted for STM_MW01741 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 28 and 29 568708000813 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 568708000814 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 568708000815 Trp docking motif [polypeptide binding]; other site 568708000816 putative active site [active] 568708000820 5 probable transmembrane helices predicted for STM_MW01751 by TMHMM2.0 at aa 13-35, 40-57, 64-81, 96-114 and 121-140 568708000821 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 568708000822 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568708000823 active site 568708000825 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 568708000826 active site clefts [active] 568708000827 zinc binding site [ion binding]; other site 568708000828 dimer interface [polypeptide binding]; other site 568708000830 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568708000831 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568708000832 Walker A/P-loop; other site 568708000833 ATP binding site [chemical binding]; other site 568708000834 Q-loop/lid; other site 568708000835 ABC transporter signature motif; other site 568708000836 Walker B; other site 568708000837 D-loop; other site 568708000838 H-loop/switch region; other site 568708000840 inner membrane transport permease; Provisional; Region: PRK15066 568708000841 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568708000843 6 probable transmembrane helices predicted for STM_MW01791 by TMHMM2.0 at aa 20-42, 62-84, 104-126, 141-163, 170-192 and 226-248 568708000844 putative fimbrial protein StiH; Provisional; Region: PRK15297 568708000846 Signal peptide predicted for STM_MW01801 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 568708000847 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 568708000848 PapC N-terminal domain; Region: PapC_N; pfam13954 568708000849 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568708000850 PapC C-terminal domain; Region: PapC_C; pfam13953 568708000852 Signal peptide predicted for STM_MW01811 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 30 and 31 568708000853 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 568708000854 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708000855 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708000858 Signal peptide predicted for STM_MW01821 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 568708000859 fimbrial protein StiA; Provisional; Region: PRK15300 568708000861 Signal peptide predicted for STM_MW01831 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24 568708000862 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568708000863 active pocket/dimerization site; other site 568708000864 active site 568708000865 phosphorylation site [posttranslational modification] 568708000867 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 568708000868 putative active site [active] 568708000869 putative metal binding site [ion binding]; other site 568708000870 Signal peptide predicted for STM_MW01851 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 568708000872 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 568708000873 tetramerization interface [polypeptide binding]; other site 568708000874 active site 568708000876 Pantoate-beta-alanine ligase; Region: PanC; cd00560 568708000877 pantoate--beta-alanine ligase; Region: panC; TIGR00018 568708000878 active site 568708000879 ATP-binding site [chemical binding]; other site 568708000880 pantoate-binding site; other site 568708000881 HXXH motif; other site 568708000883 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 568708000884 oligomerization interface [polypeptide binding]; other site 568708000885 active site 568708000886 metal binding site [ion binding]; metal-binding site 568708000888 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 568708000889 catalytic center binding site [active] 568708000890 ATP binding site [chemical binding]; other site 568708000892 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 568708000893 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 568708000894 active site 568708000895 NTP binding site [chemical binding]; other site 568708000896 metal binding triad [ion binding]; metal-binding site 568708000897 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 568708000898 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 568708000900 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 568708000901 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 568708000902 active site 568708000903 nucleotide binding site [chemical binding]; other site 568708000904 HIGH motif; other site 568708000905 KMSKS motif; other site 568708000907 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 568708000909 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 568708000911 2'-5' RNA ligase; Provisional; Region: PRK15124 568708000912 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 568708000913 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 568708000915 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 568708000916 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568708000917 ATP binding site [chemical binding]; other site 568708000918 putative Mg++ binding site [ion binding]; other site 568708000919 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708000920 nucleotide binding region [chemical binding]; other site 568708000921 ATP-binding site [chemical binding]; other site 568708000922 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 568708000927 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 568708000928 Transglycosylase; Region: Transgly; pfam00912 568708000929 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 568708000930 1 probable transmembrane helix predicted for STM_MW01961 by TMHMM2.0 at aa 60-82 568708000933 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 568708000934 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568708000935 N-terminal plug; other site 568708000936 ligand-binding site [chemical binding]; other site 568708000937 Signal peptide predicted for STM_MW01971 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 33 and 34 568708000940 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 568708000941 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 568708000942 Walker A/P-loop; other site 568708000943 ATP binding site [chemical binding]; other site 568708000944 Q-loop/lid; other site 568708000945 ABC transporter signature motif; other site 568708000946 Walker B; other site 568708000947 D-loop; other site 568708000948 H-loop/switch region; other site 568708000950 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 568708000951 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 568708000952 siderophore binding site; other site 568708000953 Signal peptide predicted for STM_MW01991 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 30 and 31 568708000955 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 568708000956 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568708000957 ABC-ATPase subunit interface; other site 568708000958 dimer interface [polypeptide binding]; other site 568708000959 putative PBP binding regions; other site 568708000960 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568708000961 ABC-ATPase subunit interface; other site 568708000962 dimer interface [polypeptide binding]; other site 568708000963 putative PBP binding regions; other site 568708000964 17 probable transmembrane helices predicted for STM_MW02001 by TMHMM2.0 at aa 35-57, 87-104, 117-136, 140-162, 169-191, 264-286, 298-316, 326-348, 372-394, 414-436, 449-467, 471-493, 505-524, 544-566, 593-615, 630-649 and 656-678 568708000966 putative fimbrial subunit StfA; Provisional; Region: PRK15283 568708000967 Signal peptide predicted for STM_MW02011 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.975 between residues 23 and 24 568708000969 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 568708000970 PapC N-terminal domain; Region: PapC_N; pfam13954 568708000971 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568708000972 PapC C-terminal domain; Region: PapC_C; pfam13953 568708000973 Signal peptide predicted for STM_MW02021 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.964 between residues 29 and 30 568708000975 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 568708000976 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708000977 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708000978 Signal peptide predicted for STM_MW02031 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 25 and 26 568708000979 1 probable transmembrane helix predicted for STM_MW02031 by TMHMM2.0 at aa 7-29 568708000982 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 568708000983 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 568708000984 Signal peptide predicted for STM_MW02051 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19 568708000986 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 568708000987 Signal peptide predicted for STM_MW02061 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 25 and 26 568708000988 1 probable transmembrane helix predicted for STM_MW02061 by TMHMM2.0 at aa 7-26 568708000990 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 568708000991 Signal peptide predicted for STM_MW02071 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 21 and 22 568708000993 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 568708000994 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568708000995 inhibitor-cofactor binding pocket; inhibition site 568708000996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708000997 catalytic residue [active] 568708000999 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 568708001000 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 568708001001 Cl- selectivity filter; other site 568708001002 Cl- binding residues [ion binding]; other site 568708001003 pore gating glutamate residue; other site 568708001004 dimer interface [polypeptide binding]; other site 568708001005 H+/Cl- coupling transport residue; other site 568708001006 11 probable transmembrane helices predicted for STM_MW02091 by TMHMM2.0 at aa 31-53, 75-97, 124-146, 179-201, 210-232, 252-274, 291-313, 328-350, 357-379, 389-411 and 418-440 568708001008 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 568708001010 hypothetical protein; Provisional; Region: PRK10578 568708001011 UPF0126 domain; Region: UPF0126; pfam03458 568708001012 UPF0126 domain; Region: UPF0126; pfam03458 568708001014 6 probable transmembrane helices predicted for STM_MW02111 by TMHMM2.0 at aa 4-23, 30-47, 62-79, 88-105, 115-137 and 149-171 568708001015 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 568708001016 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 568708001017 cobalamin binding residues [chemical binding]; other site 568708001018 putative BtuC binding residues; other site 568708001019 dimer interface [polypeptide binding]; other site 568708001021 1 probable transmembrane helix predicted for STM_MW02121 by TMHMM2.0 at aa 7-29 568708001022 Signal peptide predicted for STM_MW02121 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.875 between residues 22 and 23 568708001023 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 568708001024 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 568708001026 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 568708001027 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568708001028 Zn2+ binding site [ion binding]; other site 568708001029 Mg2+ binding site [ion binding]; other site 568708001030 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 568708001032 serine endoprotease; Provisional; Region: PRK10942 568708001033 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 568708001034 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568708001035 protein binding site [polypeptide binding]; other site 568708001036 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568708001037 Signal peptide predicted for STM_MW02151 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 26 and 27 568708001040 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 568708001041 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 568708001042 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 568708001044 hypothetical protein; Provisional; Region: PRK13677 568708001045 shikimate transporter; Provisional; Region: PRK09952 568708001046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708001047 putative substrate translocation pore; other site 568708001048 11 probable transmembrane helices predicted for STM_MW02181 by TMHMM2.0 at aa 27-46, 51-73, 85-107, 122-144, 151-173, 183-202, 244-266, 276-298, 310-329, 374-396 and 403-425 568708001050 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 568708001051 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 568708001052 trimer interface [polypeptide binding]; other site 568708001053 active site 568708001054 substrate binding site [chemical binding]; other site 568708001055 CoA binding site [chemical binding]; other site 568708001056 PII uridylyl-transferase; Provisional; Region: PRK05007 568708001057 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 568708001058 metal binding triad; other site 568708001059 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 568708001060 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568708001061 Zn2+ binding site [ion binding]; other site 568708001062 Mg2+ binding site [ion binding]; other site 568708001063 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 568708001064 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 568708001069 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 568708001070 active site 568708001072 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 568708001073 rRNA interaction site [nucleotide binding]; other site 568708001074 S8 interaction site; other site 568708001075 putative laminin-1 binding site; other site 568708001077 elongation factor Ts; Provisional; Region: tsf; PRK09377 568708001078 UBA/TS-N domain; Region: UBA; pfam00627 568708001079 Elongation factor TS; Region: EF_TS; pfam00889 568708001080 Elongation factor TS; Region: EF_TS; pfam00889 568708001083 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 568708001084 putative nucleotide binding site [chemical binding]; other site 568708001085 uridine monophosphate binding site [chemical binding]; other site 568708001086 homohexameric interface [polypeptide binding]; other site 568708001088 ribosome recycling factor; Reviewed; Region: frr; PRK00083 568708001089 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 568708001090 hinge region; other site 568708001092 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 568708001093 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 568708001094 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 568708001095 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 568708001098 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 568708001099 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 568708001100 catalytic residue [active] 568708001101 putative FPP diphosphate binding site; other site 568708001102 putative FPP binding hydrophobic cleft; other site 568708001103 dimer interface [polypeptide binding]; other site 568708001104 putative IPP diphosphate binding site; other site 568708001106 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 568708001107 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 568708001108 Signal peptide predicted for STM_MW02281 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.760 between residues 29 and 30 568708001110 8 probable transmembrane helices predicted for STM_MW02281 by TMHMM2.0 at aa 7-41, 56-74, 87-106, 121-143, 150-172, 192-211, 218-240 and 260-282 568708001111 zinc metallopeptidase RseP; Provisional; Region: PRK10779 568708001112 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 568708001113 active site 568708001114 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 568708001115 protein binding site [polypeptide binding]; other site 568708001116 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 568708001117 protein binding site [polypeptide binding]; other site 568708001118 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 568708001119 putative substrate binding region [chemical binding]; other site 568708001120 4 probable transmembrane helices predicted for STM_MW02291 by TMHMM2.0 at aa 2-21, 98-120, 376-398 and 426-445 568708001123 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 568708001124 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568708001125 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568708001126 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568708001127 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568708001128 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568708001129 Surface antigen; Region: Bac_surface_Ag; pfam01103 568708001130 Signal peptide predicted for STM_MW02301 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.980 between residues 20 and 21 568708001133 periplasmic chaperone; Provisional; Region: PRK10780 568708001134 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 568708001135 Signal peptide predicted for STM_MW02311 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 568708001137 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 568708001138 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 568708001139 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 568708001140 trimer interface [polypeptide binding]; other site 568708001141 active site 568708001142 UDP-GlcNAc binding site [chemical binding]; other site 568708001143 lipid binding site [chemical binding]; lipid-binding site 568708001146 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 568708001148 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 568708001149 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 568708001150 active site 568708001152 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 568708001153 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 568708001155 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 568708001156 RNA/DNA hybrid binding site [nucleotide binding]; other site 568708001157 active site 568708001159 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 568708001160 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 568708001161 putative active site [active] 568708001162 putative PHP Thumb interface [polypeptide binding]; other site 568708001163 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 568708001164 generic binding surface II; other site 568708001165 generic binding surface I; other site 568708001169 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 568708001170 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 568708001172 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 568708001173 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 568708001174 putative sugar binding site [chemical binding]; other site 568708001175 catalytic residues [active] 568708001176 PKD domain; Region: PKD; pfam00801 568708001177 Signal peptide predicted for STM_MW02391 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 25 and 26 568708001178 1 probable transmembrane helix predicted for STM_MW02391 by TMHMM2.0 at aa 7-29 568708001182 lysine decarboxylase LdcC; Provisional; Region: PRK15399 568708001183 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 568708001184 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 568708001185 homodimer interface [polypeptide binding]; other site 568708001186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708001187 catalytic residue [active] 568708001188 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 568708001192 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 568708001193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568708001194 putative metal binding site [ion binding]; other site 568708001196 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 568708001197 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 568708001198 TilS substrate binding domain; Region: TilS; pfam09179 568708001199 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 568708001203 Rho-binding antiterminator; Provisional; Region: PRK11625 568708001205 hypothetical protein; Provisional; Region: PRK04964 568708001207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 568708001209 hypothetical protein; Provisional; Region: PRK09256 568708001210 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 568708001212 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 568708001213 NlpE N-terminal domain; Region: NlpE; pfam04170 568708001214 Signal peptide predicted for STM_MW02471 by SignalP 2.0 HMM (Signal peptide probability 0.949) with cleavage site probability 0.649 between residues 25 and 26 568708001216 prolyl-tRNA synthetase; Provisional; Region: PRK09194 568708001217 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 568708001218 dimer interface [polypeptide binding]; other site 568708001219 motif 1; other site 568708001220 active site 568708001221 motif 2; other site 568708001222 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 568708001223 putative deacylase active site [active] 568708001224 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568708001225 active site 568708001226 motif 3; other site 568708001227 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 568708001228 anticodon binding site; other site 568708001232 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 568708001233 homodimer interaction site [polypeptide binding]; other site 568708001234 cofactor binding site; other site 568708001236 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 568708001237 Signal peptide predicted for STM_MW02501 by SignalP 2.0 HMM (Signal peptide probability 0.667) with cleavage site probability 0.306 between residues 19 and 20 568708001238 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 568708001239 lipoprotein, YaeC family; Region: TIGR00363 568708001241 Signal peptide predicted for STM_MW02511 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.356 between residues 21 and 22 568708001242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708001243 dimer interface [polypeptide binding]; other site 568708001244 conserved gate region; other site 568708001245 ABC-ATPase subunit interface; other site 568708001246 5 probable transmembrane helices predicted for STM_MW02521 by TMHMM2.0 at aa 20-42, 55-77, 81-103, 144-166 and 181-203 568708001248 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 568708001249 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 568708001250 Walker A/P-loop; other site 568708001251 ATP binding site [chemical binding]; other site 568708001252 Q-loop/lid; other site 568708001253 ABC transporter signature motif; other site 568708001254 Walker B; other site 568708001255 D-loop; other site 568708001256 H-loop/switch region; other site 568708001257 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 568708001260 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568708001261 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568708001262 active site 568708001263 catalytic tetrad [active] 568708001265 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708001266 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708001267 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 568708001268 putative effector binding pocket; other site 568708001269 dimerization interface [polypeptide binding]; other site 568708001272 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 568708001273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708001274 putative substrate translocation pore; other site 568708001275 12 probable transmembrane helices predicted for STM_MW02561 by TMHMM2.0 at aa 7-29, 39-61, 70-89, 99-121, 128-150, 160-182, 202-224, 234-256, 263-285, 289-311, 331-353 and 363-382 568708001277 hypothetical protein; Provisional; Region: PRK05421 568708001278 putative catalytic site [active] 568708001279 putative metal binding site [ion binding]; other site 568708001280 putative phosphate binding site [ion binding]; other site 568708001281 putative catalytic site [active] 568708001282 putative phosphate binding site [ion binding]; other site 568708001283 putative metal binding site [ion binding]; other site 568708001285 Methyltransferase domain; Region: Methyltransf_23; pfam13489 568708001286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708001287 S-adenosylmethionine binding site [chemical binding]; other site 568708001289 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 568708001290 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568708001291 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568708001292 catalytic residue [active] 568708001293 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568708001294 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568708001298 Signal peptide predicted for STM_MW02591 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.403 between residues 21 and 22 568708001299 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 568708001301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708001303 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 568708001304 RNA/DNA hybrid binding site [nucleotide binding]; other site 568708001305 active site 568708001307 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 568708001308 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 568708001309 active site 568708001310 catalytic site [active] 568708001311 substrate binding site [chemical binding]; other site 568708001313 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 568708001314 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 568708001316 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 568708001318 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 568708001319 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 568708001321 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 568708001323 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 568708001324 ImpE protein; Region: ImpE; pfam07024 568708001326 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 568708001327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708001328 Walker A motif; other site 568708001329 ATP binding site [chemical binding]; other site 568708001330 Walker B motif; other site 568708001331 arginine finger; other site 568708001332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708001333 Walker A motif; other site 568708001334 ATP binding site [chemical binding]; other site 568708001335 Walker B motif; other site 568708001336 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568708001340 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 568708001342 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 568708001343 Protein of unknown function (DUF877); Region: DUF877; pfam05943 568708001345 Signal peptide predicted for STM_MW02771 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.996 between residues 23 and 24 568708001346 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 568708001348 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 568708001349 Signal peptide predicted for STM_MW02831 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.962 between residues 26 and 27 568708001350 1 probable transmembrane helix predicted for STM_MW02831 by TMHMM2.0 at aa 7-26 568708001351 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 568708001353 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 568708001354 Signal peptide predicted for STM_MW02851 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.844 between residues 31 and 32 568708001355 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 568708001356 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 568708001358 hypothetical protein; Provisional; Region: PRK08126 568708001359 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 568708001360 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568708001361 ligand binding site [chemical binding]; other site 568708001363 1 probable transmembrane helix predicted for STM_MW02871 by TMHMM2.0 at aa 243-265 568708001365 1 probable transmembrane helix predicted for STM_MW02881 by TMHMM2.0 at aa 34-56 568708001366 Signal peptide predicted for STM_MW02891 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.997 between residues 18 and 19 568708001367 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 568708001368 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 568708001369 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 568708001370 Signal peptide predicted for STM_MW02901 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.985 between residues 34 and 35 568708001371 5 probable transmembrane helices predicted for STM_MW02901 by TMHMM2.0 at aa 13-35, 40-62, 69-88, 98-120 and 530-547 568708001374 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 568708001376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 568708001377 Signal peptide predicted for STM_MW02921 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.847 between residues 23 and 24 568708001379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 568708001380 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 568708001381 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 568708001384 Uncharacterized conserved protein [Function unknown]; Region: COG5435 568708001386 PAAR motif; Region: PAAR_motif; pfam05488 568708001387 RHS Repeat; Region: RHS_repeat; pfam05593 568708001388 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 568708001389 RHS Repeat; Region: RHS_repeat; pfam05593 568708001390 RHS Repeat; Region: RHS_repeat; pfam05593 568708001391 RHS protein; Region: RHS; pfam03527 568708001392 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 568708001393 1 probable transmembrane helix predicted for STM_MW02961 by TMHMM2.0 at aa 17-39 568708001399 lacks N-terminal region 568708001400 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 568708001402 has a frameshift after residue 81; pfam_scan;Pfam:PF08845; E()=3.7E-13;score=48.3;query17-49;description=DUF1813 568708001404 Transposase; Region: HTH_Tnp_1; cl17663 568708001406 lacks the N-terminal region and has three frameshifts after residues 43, 142 and 148; pfam_scan;Pfam:PF00665; E()=5.8E-19;score=68.1;query10-139;description=rve 568708001408 Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221 568708001409 Signal peptide predicted for STM_MW03091 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 26 and 27 568708001411 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 568708001412 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708001413 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708001416 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 568708001417 PapC N-terminal domain; Region: PapC_N; pfam13954 568708001418 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568708001419 PapC C-terminal domain; Region: PapC_C; pfam13953 568708001420 Signal peptide predicted for STM_MW03111 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.930 between residues 21 and 22 568708001422 putative pilin structural protein SafD; Provisional; Region: PRK15222 568708001423 Signal peptide predicted for STM_MW03121 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 30 and 31 568708001425 1 probable transmembrane helix predicted for STM_MW03121 by TMHMM2.0 at aa 12-31 568708001426 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 568708001427 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 568708001428 putative active site [active] 568708001429 putative metal binding site [ion binding]; other site 568708001431 PerC transcriptional activator; Region: PerC; pfam06069 568708001433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708001434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708001435 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568708001436 dimerization interface [polypeptide binding]; other site 568708001439 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 568708001441 Signal peptide predicted for STM_MW03171 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.976 between residues 22 and 23 568708001442 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 568708001443 dimer interface [polypeptide binding]; other site 568708001444 Signal peptide predicted for STM_MW03181 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.733 between residues 23 and 24 568708001445 C-N hydrolase family amidase; Provisional; Region: PRK10438 568708001446 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 568708001447 putative active site [active] 568708001448 catalytic triad [active] 568708001449 dimer interface [polypeptide binding]; other site 568708001450 multimer interface [polypeptide binding]; other site 568708001452 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 568708001453 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568708001454 active site 568708001455 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 568708001459 2 probable transmembrane helices predicted for STM_MW03201 by TMHMM2.0 at aa 10-32 and 39-61 568708001460 Signal peptide predicted for STM_MW03201 by SignalP 2.0 HMM (Signal peptide probability 0.711) with cleavage site probability 0.289 between residues 32 and 33 568708001461 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 568708001462 dimer interface [polypeptide binding]; other site 568708001463 active site 568708001465 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 568708001466 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 568708001467 putative active site [active] 568708001468 putative dimer interface [polypeptide binding]; other site 568708001470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 568708001471 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568708001473 Signal peptide predicted for STM_MW03231 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.831 between residues 19 and 20 568708001474 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 568708001475 active site 568708001476 DNA polymerase IV; Validated; Region: PRK02406 568708001477 DNA binding site [nucleotide binding] 568708001481 contains a frameshift after residue 297; pfam_scan;Pfam:PF01139; E()=1.4E-22;score=79.4;query13-108;description=UPF0027 568708001483 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 568708001484 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 568708001486 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 568708001487 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 568708001488 metal binding site [ion binding]; metal-binding site 568708001489 dimer interface [polypeptide binding]; other site 568708001492 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568708001493 active site 568708001495 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 568708001497 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 568708001499 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568708001500 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 568708001501 trimer interface [polypeptide binding]; other site 568708001502 eyelet of channel; other site 568708001504 Signal peptide predicted for STM_MW03311 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 568708001505 gamma-glutamyl kinase; Provisional; Region: PRK05429 568708001506 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 568708001507 nucleotide binding site [chemical binding]; other site 568708001508 homotetrameric interface [polypeptide binding]; other site 568708001509 putative phosphate binding site [ion binding]; other site 568708001510 putative allosteric binding site; other site 568708001511 PUA domain; Region: PUA; pfam01472 568708001514 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 568708001515 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 568708001516 putative catalytic cysteine [active] 568708001518 BTP1 568708001519 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 568708001520 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 568708001521 Int/Topo IB signature motif; other site 568708001523 Helix-turn-helix domain; Region: HTH_17; pfam12728 568708001524 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 568708001525 Protein of unknown function (DUF550); Region: DUF550; pfam04447 568708001527 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 568708001528 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 568708001530 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 568708001532 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 568708001534 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 568708001536 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 568708001538 1 probable transmembrane helix predicted for STM_MW03491 by TMHMM2.0 at aa 15-37 568708001539 Antirestriction protein Ral; Region: Ral; pfam11058 568708001541 Protein of unknown function (DUF2767); Region: DUF2767; cl08104 568708001543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708001544 non-specific DNA binding site [nucleotide binding]; other site 568708001545 Predicted transcriptional regulator [Transcription]; Region: COG2932 568708001546 salt bridge; other site 568708001547 sequence-specific DNA binding site [nucleotide binding]; other site 568708001548 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568708001549 Catalytic site [active] 568708001552 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 568708001553 Bacteriophage CII protein; Region: Phage_CII; pfam05269 568708001555 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 568708001557 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 568708001558 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 568708001559 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 568708001560 Walker A motif; other site 568708001561 ATP binding site [chemical binding]; other site 568708001562 Walker B motif; other site 568708001563 DNA binding loops [nucleotide binding] 568708001566 1 probable transmembrane helix predicted for STM_MW03601 by TMHMM2.0 at aa 10-32 568708001567 NinB protein; Region: NinB; pfam05772 568708001569 NINE Protein; Region: NinE; pfam05322 568708001571 NinF protein; Region: NinF; pfam05810 568708001573 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 568708001575 Phage NinH protein; Region: Phage_NinH; pfam06322 568708001577 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 568708001579 2 probable transmembrane helices predicted for STM_MW03711 by TMHMM2.0 at aa 7-26 and 30-49 568708001580 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 568708001581 catalytic residues [active] 568708001582 Signal peptide predicted for STM_MW03721 by SignalP 2.0 HMM (Signal peptide probability 0.625) with cleavage site probability 0.154 between residues 23 and 24 568708001583 1 probable transmembrane helix predicted for STM_MW03721 by TMHMM2.0 at aa 7-29 568708001585 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 568708001587 1 probable transmembrane helix predicted for STM_MW03731 by TMHMM2.0 at aa 15-37 568708001588 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 568708001589 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 568708001590 ORF11CD3 domain; Region: ORF11CD3; pfam10549 568708001593 hypothetical protein; Region: PHA00780 568708001595 Terminase-like family; Region: Terminase_6; pfam03237 568708001596 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 568708001597 Phage terminase large subunit; Region: Terminase_3; cl12054 568708001599 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 568708001601 coat protein; Region: PHA01511 568708001602 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 568708001604 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 568708001606 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 568708001608 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 568708001610 Head binding; Region: Head_binding; pfam09008 568708001611 Salmonella phage P22 tail-spike; Region: PhageP22-tail; pfam09251 568708001614 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 568708001616 11 probable transmembrane helices predicted for STM_MW03911 by TMHMM2.0 at aa 13-35, 40-59, 72-94, 135-157, 166-188, 201-218, 225-242, 246-268, 275-294, 314-333 and 345-367 568708001617 1 probable transmembrane helix predicted for STM_MW03921 by TMHMM2.0 at aa 10-32 568708001618 HTH-like domain; Region: HTH_21; pfam13276 568708001619 Integrase core domain; Region: rve; pfam00665 568708001620 Integrase core domain; Region: rve_2; pfam13333 568708001622 lacks the N-terminal region and has a frameshift after residue 92; pfam_scan;Pfam:PF08841; E()=9.3E-122;score=405.6;query 1-236;description=DDR 568708001624 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 568708001626 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 568708001627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708001628 putative substrate translocation pore; other site 568708001629 12 probable transmembrane helices predicted for STM_MW03981 by TMHMM2.0 at aa 16-38, 53-75, 82-104, 108-130, 137-159, 169-191, 221-243, 253-275, 282-304, 308-330, 347-369 and 373-395 568708001631 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 568708001632 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 568708001633 substrate binding site [chemical binding]; other site 568708001634 ligand binding site [chemical binding]; other site 568708001636 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 568708001637 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 568708001638 hypothetical protein; Provisional; Region: PRK14812 568708001639 substrate binding site [chemical binding]; other site 568708001641 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568708001642 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568708001644 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 568708001646 transcriptional activator TtdR; Provisional; Region: PRK09801 568708001647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708001648 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 568708001649 putative effector binding pocket; other site 568708001650 putative dimerization interface [polypeptide binding]; other site 568708001653 YjzC-like protein; Region: YjzC; pfam14168 568708001654 Signal peptide predicted for STM_MW04051 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.628 between residues 25 and 26 568708001655 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 568708001656 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708001657 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708001660 Signal peptide predicted for STM_MW04061 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 29 and 30 568708001661 1 probable transmembrane helix predicted for STM_MW04061 by TMHMM2.0 at aa 7-29 568708001662 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 568708001663 Signal peptide predicted for STM_MW04071 by SignalP 2.0 HMM (Signal peptide probability 0.933) with cleavage site probability 0.750 between residues 18 and 19 568708001664 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 568708001665 PapC N-terminal domain; Region: PapC_N; pfam13954 568708001666 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568708001667 PapC C-terminal domain; Region: PapC_C; pfam13953 568708001669 Signal peptide predicted for STM_MW04081 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 26 and 27 568708001670 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 568708001671 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708001672 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708001675 1 probable transmembrane helix predicted for STM_MW04091 by TMHMM2.0 at aa 9-31 568708001676 Signal peptide predicted for STM_MW04091 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.791 between residues 28 and 29 568708001677 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 568708001679 Signal peptide predicted for STM_MW04101 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 22 and 23 568708001680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 568708001681 1 probable transmembrane helix predicted for STM_MW04111 by TMHMM2.0 at aa 145-167 568708001682 Signal peptide predicted for STM_MW04121 by SignalP 2.0 HMM (Signal peptide probability 0.903) with cleavage site probability 0.632 between residues 26 and 27 568708001683 1 probable transmembrane helix predicted for STM_MW04121 by TMHMM2.0 at aa 7-29 568708001684 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 568708001685 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708001686 Signal peptide predicted for STM_MW04131 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.958 between residues 26 and 27 568708001687 2 probable transmembrane helices predicted for STM_MW04131 by TMHMM2.0 at aa 7-29 and 223-245 568708001689 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 568708001690 DNA binding site [nucleotide binding] 568708001691 Signal peptide predicted for STM_MW04151 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.718 between residues 25 and 26 568708001692 1 probable transmembrane helix predicted for STM_MW04151 by TMHMM2.0 at aa 7-29 568708001693 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 568708001694 Signal peptide predicted for STM_MW04161 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708001696 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 568708001697 DNA binding residues [nucleotide binding] 568708001698 dimerization interface [polypeptide binding]; other site 568708001700 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 568708001701 Signal peptide predicted for STM_MW04191 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.408 between residues 20 and 21 568708001702 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 568708001704 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 568708001706 12 probable transmembrane helices predicted for STM_MW04211 by TMHMM2.0 at aa 7-29, 339-361, 368-390, 394-416, 443-465, 475-497, 543-565, 882-899, 906-928, 933-955, 983-1005 and 1015-1037 568708001707 Signal peptide predicted for STM_MW04211 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.452 between residues 30 and 31 568708001708 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568708001709 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568708001710 HlyD family secretion protein; Region: HlyD_3; pfam13437 568708001712 1 probable transmembrane helix predicted for STM_MW04221 by TMHMM2.0 at aa 7-29 568708001713 Signal peptide predicted for STM_MW04221 by SignalP 2.0 HMM (Signal peptide probability 0.893) with cleavage site probability 0.796 between residues 24 and 25 568708001714 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 568708001715 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568708001716 metal-binding site [ion binding] 568708001717 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568708001718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708001719 motif II; other site 568708001721 8 probable transmembrane helices predicted for STM_MW04231 by TMHMM2.0 at aa 99-121, 136-156, 169-191, 201-219, 353-375, 380-402, 696-718 and 722-744 568708001724 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 568708001725 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 568708001726 DNA binding residues [nucleotide binding] 568708001727 dimer interface [polypeptide binding]; other site 568708001728 copper binding site [ion binding]; other site 568708001731 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568708001732 metal-binding site [ion binding] 568708001734 putative sialic acid transporter; Region: 2A0112; TIGR00891 568708001735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708001736 putative substrate translocation pore; other site 568708001737 10 probable transmembrane helices predicted for STM_MW04261 by TMHMM2.0 at aa 13-35, 50-72, 79-101, 105-127, 140-162, 172-194, 215-232, 252-274, 287-309 and 370-392 568708001739 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 568708001740 DNA methylase; Region: N6_N4_Mtase; cl17433 568708001741 DNA methylase; Region: N6_N4_Mtase; pfam01555 568708001743 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 568708001744 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 568708001745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 568708001746 VRR-NUC domain; Region: VRR_NUC; pfam08774 568708001749 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 568708001751 9 probable transmembrane helices predicted for STM_MW04301 by TMHMM2.0 at aa 20-42, 55-77, 97-119, 126-148, 185-207, 220-237, 322-344, 357-379 and 407-429 568708001752 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 568708001753 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 568708001754 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 568708001756 8 probable transmembrane helices predicted for STM_MW04311 by TMHMM2.0 at aa 7-26, 78-100, 121-143, 158-180, 193-215, 230-248, 261-283 and 303-325 568708001757 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568708001758 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 568708001759 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568708001760 N-terminal plug; other site 568708001761 ligand-binding site [chemical binding]; other site 568708001762 Signal peptide predicted for STM_MW04341 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 30 and 31 568708001765 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 568708001766 6 probable transmembrane helices predicted for STM_MW04351 by TMHMM2.0 at aa 5-27, 39-61, 71-90, 123-140, 150-167 and 187-204 568708001768 hypothetical protein; Provisional; Region: PRK09929 568708001769 Signal peptide predicted for STM_MW04361 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 568708001771 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 568708001772 Propionate catabolism activator; Region: PrpR_N; pfam06506 568708001773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708001774 Walker A motif; other site 568708001775 ATP binding site [chemical binding]; other site 568708001776 Walker B motif; other site 568708001777 arginine finger; other site 568708001778 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568708001782 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 568708001783 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 568708001784 tetramer interface [polypeptide binding]; other site 568708001785 active site 568708001786 Mg2+/Mn2+ binding site [ion binding]; other site 568708001788 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 568708001789 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 568708001790 dimer interface [polypeptide binding]; other site 568708001791 active site 568708001792 citrylCoA binding site [chemical binding]; other site 568708001793 oxalacetate/citrate binding site [chemical binding]; other site 568708001794 coenzyme A binding site [chemical binding]; other site 568708001795 catalytic triad [active] 568708001797 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 568708001798 2-methylcitrate dehydratase; Region: prpD; TIGR02330 568708001800 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 568708001801 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568708001802 acyl-activating enzyme (AAE) consensus motif; other site 568708001803 AMP binding site [chemical binding]; other site 568708001804 active site 568708001805 CoA binding site [chemical binding]; other site 568708001807 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 568708001808 dimer interface [polypeptide binding]; other site 568708001809 active site 568708001810 Schiff base residues; other site 568708001812 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 568708001813 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568708001814 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568708001815 Signal peptide predicted for STM_MW04431 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.920 between residues 27 and 28 568708001817 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 568708001818 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568708001819 ligand binding site [chemical binding]; other site 568708001820 flexible hinge region; other site 568708001822 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 568708001823 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568708001825 microcin B17 transporter; Reviewed; Region: PRK11098 568708001826 6 probable transmembrane helices predicted for STM_MW04461 by TMHMM2.0 at aa 23-45, 52-74, 104-126, 172-194, 209-231 and 299-321 568708001828 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 568708001829 Signal peptide predicted for STM_MW04471 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.527 between residues 26 and 27 568708001831 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 568708001833 2 probable transmembrane helices predicted for STM_MW04481 by TMHMM2.0 at aa 25-47 and 68-90 568708001834 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 568708001836 2 probable transmembrane helices predicted for STM_MW04491 by TMHMM2.0 at aa 13-32 and 37-59 568708001837 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 568708001838 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 568708001839 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 568708001842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 568708001843 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 568708001844 1 probable transmembrane helix predicted for STM_MW04511 by TMHMM2.0 at aa 13-35 568708001846 drug efflux system protein MdtG; Provisional; Region: PRK09874 568708001847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708001848 putative substrate translocation pore; other site 568708001849 10 probable transmembrane helices predicted for STM_MW04521 by TMHMM2.0 at aa 7-29, 44-66, 79-101, 161-183, 204-226, 249-271, 283-302, 307-329, 342-364 and 369-391 568708001851 anti-RssB factor; Provisional; Region: PRK10244 568708001853 hypothetical protein; Provisional; Region: PRK11505 568708001854 psiF repeat; Region: PsiF_repeat; pfam07769 568708001855 psiF repeat; Region: PsiF_repeat; pfam07769 568708001856 Signal peptide predicted for STM_MW04541 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.516 between residues 20 and 21 568708001857 1 probable transmembrane helix predicted for STM_MW04541 by TMHMM2.0 at aa 5-22 568708001859 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 568708001860 MASE2 domain; Region: MASE2; pfam05230 568708001861 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568708001862 metal binding site [ion binding]; metal-binding site 568708001863 active site 568708001864 I-site; other site 568708001866 4 probable transmembrane helices predicted for STM_MW04551 by TMHMM2.0 at aa 45-67, 105-127, 140-162 and 177-199 568708001868 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 568708001869 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 568708001871 hypothetical protein; Validated; Region: PRK00124 568708001873 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 568708001874 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 568708001875 ADP binding site [chemical binding]; other site 568708001876 magnesium binding site [ion binding]; other site 568708001877 putative shikimate binding site; other site 568708001879 hypothetical protein; Provisional; Region: PRK10380 568708001880 hypothetical protein; Provisional; Region: PRK10481 568708001882 hypothetical protein; Provisional; Region: PRK10579 568708001884 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 568708001886 fructokinase; Reviewed; Region: PRK09557 568708001887 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568708001888 nucleotide binding site [chemical binding]; other site 568708001890 MFS transport protein AraJ; Provisional; Region: PRK10091 568708001891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708001892 putative substrate translocation pore; other site 568708001894 12 probable transmembrane helices predicted for STM_MW04641 by TMHMM2.0 at aa 5-27, 42-64, 71-93, 103-120, 125-147, 157-179, 200-222, 237-254, 266-288, 293-315, 320-342 and 352-374 568708001895 Signal peptide predicted for STM_MW04641 by SignalP 2.0 HMM (Signal peptide probability 0.864) with cleavage site probability 0.547 between residues 18 and 19 568708001896 exonuclease subunit SbcC; Provisional; Region: PRK10246 568708001897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708001898 Walker A/P-loop; other site 568708001899 ATP binding site [chemical binding]; other site 568708001900 Q-loop/lid; other site 568708001901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708001902 ABC transporter signature motif; other site 568708001903 Walker B; other site 568708001904 D-loop; other site 568708001905 H-loop/switch region; other site 568708001906 exonuclease subunit SbcD; Provisional; Region: PRK10966 568708001907 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 568708001908 active site 568708001909 metal binding site [ion binding]; metal-binding site 568708001910 DNA binding site [nucleotide binding] 568708001911 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 568708001913 transcriptional regulator PhoB; Provisional; Region: PRK10161 568708001914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708001915 active site 568708001916 phosphorylation site [posttranslational modification] 568708001917 intermolecular recognition site; other site 568708001918 dimerization interface [polypeptide binding]; other site 568708001919 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708001920 DNA binding site [nucleotide binding] 568708001923 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 568708001924 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 568708001925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568708001926 putative active site [active] 568708001927 heme pocket [chemical binding]; other site 568708001928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708001929 dimer interface [polypeptide binding]; other site 568708001930 phosphorylation site [posttranslational modification] 568708001931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708001932 ATP binding site [chemical binding]; other site 568708001933 Mg2+ binding site [ion binding]; other site 568708001934 G-X-G motif; other site 568708001935 Signal peptide predicted for STM_MW04681 by SignalP 2.0 HMM (Signal peptide probability 0.909) with cleavage site probability 0.844 between residues 37 and 38 568708001936 1 probable transmembrane helix predicted for STM_MW04681 by TMHMM2.0 at aa 12-34 568708001940 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 568708001941 Signal peptide predicted for STM_MW04691 by SignalP 2.0 HMM (Signal peptide probability 0.823) with cleavage site probability 0.742 between residues 24 and 25 568708001943 12 probable transmembrane helices predicted for STM_MW04691 by TMHMM2.0 at aa 13-35, 41-63, 76-98, 118-140, 147-169, 189-211, 223-245, 276-298, 305-327, 337-359, 371-393 and 408-426 568708001944 putative proline-specific permease; Provisional; Region: proY; PRK10580 568708001945 Signal peptide predicted for STM_MW04701 by SignalP 2.0 HMM (Signal peptide probability 0.943) with cleavage site probability 0.472 between residues 36 and 37 568708001947 12 probable transmembrane helices predicted for STM_MW04701 by TMHMM2.0 at aa 16-34, 44-63, 83-105, 120-142, 154-176, 196-218, 239-261, 276-298, 329-351, 356-378, 399-421 and 426-445 568708001948 maltodextrin glucosidase; Provisional; Region: PRK10785 568708001949 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 568708001950 homodimer interface [polypeptide binding]; other site 568708001951 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 568708001952 active site 568708001953 homodimer interface [polypeptide binding]; other site 568708001954 catalytic site [active] 568708001956 peroxidase; Provisional; Region: PRK15000 568708001957 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 568708001958 dimer interface [polypeptide binding]; other site 568708001959 decamer (pentamer of dimers) interface [polypeptide binding]; other site 568708001960 catalytic triad [active] 568708001961 peroxidatic and resolving cysteines [active] 568708001964 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 568708001966 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 568708001967 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 568708001969 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 568708001970 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 568708001972 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 568708001973 1 probable transmembrane helix predicted for STM_MW04761 by TMHMM2.0 at aa 20-39 568708001975 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 568708001976 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 568708001977 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 568708001978 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 568708001979 Signal peptide predicted for STM_MW04771 by SignalP 2.0 HMM (Signal peptide probability 0.667) with cleavage site probability 0.508 between residues 30 and 31 568708001980 6 probable transmembrane helices predicted for STM_MW04771 by TMHMM2.0 at aa 7-29, 452-471, 476-498, 503-525, 546-568 and 583-605 568708001983 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 568708001984 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 568708001985 Protein export membrane protein; Region: SecD_SecF; pfam02355 568708001986 6 probable transmembrane helices predicted for STM_MW04781 by TMHMM2.0 at aa 24-46, 143-162, 169-191, 195-217, 248-270 and 275-297 568708001989 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 568708001990 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568708001992 Predicted transcriptional regulator [Transcription]; Region: COG2378 568708001993 HTH domain; Region: HTH_11; pfam08279 568708001994 WYL domain; Region: WYL; pfam13280 568708001996 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 568708001997 active site 568708001999 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 568708002001 Signal peptide predicted for STM_MW04831 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708002002 hypothetical protein; Provisional; Region: PRK11530 568708002004 Signal peptide predicted for STM_MW04841 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.768 between residues 24 and 25 568708002005 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 568708002006 ATP cone domain; Region: ATP-cone; pfam03477 568708002008 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 568708002009 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 568708002010 catalytic motif [active] 568708002011 Zn binding site [ion binding]; other site 568708002012 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 568708002015 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 568708002016 homopentamer interface [polypeptide binding]; other site 568708002017 active site 568708002019 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 568708002020 putative RNA binding site [nucleotide binding]; other site 568708002022 thiamine monophosphate kinase; Provisional; Region: PRK05731 568708002023 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 568708002024 ATP binding site [chemical binding]; other site 568708002025 dimerization interface [polypeptide binding]; other site 568708002028 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 568708002029 tetramer interfaces [polypeptide binding]; other site 568708002030 binuclear metal-binding site [ion binding]; other site 568708002031 Signal peptide predicted for STM_MW04901 by SignalP 2.0 HMM (Signal peptide probability 0.799) with cleavage site probability 0.677 between residues 44 and 45 568708002032 3 probable transmembrane helices predicted for STM_MW04901 by TMHMM2.0 at aa 21-43, 53-75 and 140-162 568708002034 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568708002035 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568708002036 active site 568708002037 catalytic tetrad [active] 568708002039 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 568708002040 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 568708002041 TPP-binding site; other site 568708002042 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568708002043 PYR/PP interface [polypeptide binding]; other site 568708002044 dimer interface [polypeptide binding]; other site 568708002045 TPP binding site [chemical binding]; other site 568708002046 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568708002050 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568708002051 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568708002052 substrate binding pocket [chemical binding]; other site 568708002053 chain length determination region; other site 568708002054 substrate-Mg2+ binding site; other site 568708002055 catalytic residues [active] 568708002056 aspartate-rich region 1; other site 568708002057 active site lid residues [active] 568708002058 aspartate-rich region 2; other site 568708002060 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 568708002062 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 568708002063 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 568708002064 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 568708002065 Ligand Binding Site [chemical binding]; other site 568708002066 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568708002067 active site residue [active] 568708002070 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568708002071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708002072 dimer interface [polypeptide binding]; other site 568708002073 conserved gate region; other site 568708002074 ABC-ATPase subunit interface; other site 568708002075 6 probable transmembrane helices predicted for STM_MW04961 by TMHMM2.0 at aa 12-34, 66-88, 101-123, 133-155, 187-209 and 234-253 568708002077 Signal peptide predicted for STM_MW04961 by SignalP 2.0 HMM (Signal peptide probability 0.955) with cleavage site probability 0.445 between residues 29 and 30 568708002078 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 568708002079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708002080 dimer interface [polypeptide binding]; other site 568708002081 conserved gate region; other site 568708002082 putative PBP binding loops; other site 568708002083 ABC-ATPase subunit interface; other site 568708002084 7 probable transmembrane helices predicted for STM_MW04971 by TMHMM2.0 at aa 15-37, 74-96, 111-133, 140-162, 199-221, 226-245 and 255-277 568708002086 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 568708002087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708002088 Walker A/P-loop; other site 568708002089 ATP binding site [chemical binding]; other site 568708002090 Q-loop/lid; other site 568708002091 ABC transporter signature motif; other site 568708002092 Walker B; other site 568708002093 D-loop; other site 568708002094 H-loop/switch region; other site 568708002095 TOBE domain; Region: TOBE_2; pfam08402 568708002098 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568708002099 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 568708002101 transcriptional regulator protein; Region: phnR; TIGR03337 568708002102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708002103 DNA-binding site [nucleotide binding]; DNA binding site 568708002104 UTRA domain; Region: UTRA; pfam07702 568708002107 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 568708002108 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568708002109 catalytic residue [active] 568708002111 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 568708002112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708002113 motif II; other site 568708002115 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 568708002116 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 568708002117 conserved cys residue [active] 568708002119 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 568708002120 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 568708002121 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 568708002124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 568708002125 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 568708002127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708002128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568708002129 putative substrate translocation pore; other site 568708002131 11 probable transmembrane helices predicted for STM_MW05061 by TMHMM2.0 at aa 15-37, 44-66, 76-98, 132-154, 159-181, 212-234, 249-268, 275-297, 301-323, 336-358 and 363-380 568708002133 Sel1-like repeats; Region: SEL1; smart00671 568708002134 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 568708002135 Sel1 repeat; Region: Sel1; pfam08238 568708002136 Sel1-like repeats; Region: SEL1; smart00671 568708002137 Signal peptide predicted for STM_MW05081 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.938 between residues 22 and 23 568708002139 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 568708002140 Sel1-like repeats; Region: SEL1; smart00671 568708002141 Sel1-like repeats; Region: SEL1; smart00671 568708002143 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 568708002144 UbiA prenyltransferase family; Region: UbiA; pfam01040 568708002145 9 probable transmembrane helices predicted for STM_MW05101 by TMHMM2.0 at aa 12-34, 38-60, 81-103, 108-127, 134-156, 161-183, 209-231, 235-252 and 264-286 568708002147 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 568708002148 3 probable transmembrane helices predicted for STM_MW05111 by TMHMM2.0 at aa 15-37, 44-66 and 76-98 568708002150 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 568708002151 Subunit III/IV interface [polypeptide binding]; other site 568708002152 Subunit I/III interface [polypeptide binding]; other site 568708002153 5 probable transmembrane helices predicted for STM_MW05121 by TMHMM2.0 at aa 5-24, 34-56, 63-85, 105-127 and 148-170 568708002155 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 568708002156 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 568708002157 D-pathway; other site 568708002158 Putative ubiquinol binding site [chemical binding]; other site 568708002159 Low-spin heme (heme b) binding site [chemical binding]; other site 568708002160 Putative water exit pathway; other site 568708002161 Binuclear center (heme o3/CuB) [ion binding]; other site 568708002162 K-pathway; other site 568708002163 Putative proton exit pathway; other site 568708002164 14 probable transmembrane helices predicted for STM_MW05131 by TMHMM2.0 at aa 15-37, 57-79, 105-127, 140-162, 191-213, 233-255, 275-297, 310-332, 347-369, 382-404, 414-436, 456-478, 498-520 and 590-612 568708002166 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 568708002167 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 568708002168 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 568708002170 3 probable transmembrane helices predicted for STM_MW05141 by TMHMM2.0 at aa 12-30, 45-67 and 88-110 568708002172 Signal peptide predicted for STM_MW05141 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.595 between residues 30 and 31 568708002173 muropeptide transporter; Reviewed; Region: ampG; PRK11902 568708002174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708002175 putative substrate translocation pore; other site 568708002176 14 probable transmembrane helices predicted for STM_MW05151 by TMHMM2.0 at aa 13-35, 50-69, 82-104, 109-131, 144-166, 176-195, 223-245, 260-282, 287-309, 319-341, 354-376, 381-403, 424-446 and 466-485 568708002178 Signal peptide predicted for STM_MW05151 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.787 between residues 37 and 38 568708002179 hypothetical protein; Provisional; Region: PRK11627 568708002180 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 568708002183 transcriptional regulator BolA; Provisional; Region: PRK11628 568708002185 trigger factor; Provisional; Region: tig; PRK01490 568708002186 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 568708002187 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 568708002191 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 568708002192 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 568708002193 oligomer interface [polypeptide binding]; other site 568708002194 active site residues [active] 568708002196 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 568708002197 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 568708002198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708002199 Walker A motif; other site 568708002200 ATP binding site [chemical binding]; other site 568708002201 Walker B motif; other site 568708002202 Iron permease FTR1 family; Region: FTR1; cl00475 568708002203 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568708002207 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 568708002208 Found in ATP-dependent protease La (LON); Region: LON; smart00464 568708002209 Found in ATP-dependent protease La (LON); Region: LON; smart00464 568708002210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708002211 Walker A motif; other site 568708002212 ATP binding site [chemical binding]; other site 568708002213 Walker B motif; other site 568708002214 arginine finger; other site 568708002215 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 568708002219 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568708002220 IHF dimer interface [polypeptide binding]; other site 568708002221 IHF - DNA interface [nucleotide binding]; other site 568708002223 periplasmic folding chaperone; Provisional; Region: PRK10788 568708002224 SurA N-terminal domain; Region: SurA_N_3; cl07813 568708002225 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 568708002226 1 probable transmembrane helix predicted for STM_MW05231 by TMHMM2.0 at aa 13-35 568708002229 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 568708002230 Signal peptide predicted for STM_MW05241 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 25 and 26 568708002232 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 568708002233 active site 568708002235 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 568708002236 Ligand Binding Site [chemical binding]; other site 568708002238 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 568708002239 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 568708002240 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 568708002242 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 568708002243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708002244 active site 568708002245 motif I; other site 568708002246 motif II; other site 568708002248 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 568708002249 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 568708002250 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568708002251 catalytic residue [active] 568708002253 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568708002254 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568708002255 putative DNA binding site [nucleotide binding]; other site 568708002256 putative Zn2+ binding site [ion binding]; other site 568708002257 AsnC family; Region: AsnC_trans_reg; pfam01037 568708002259 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 568708002260 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568708002261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708002262 Walker A/P-loop; other site 568708002263 ATP binding site [chemical binding]; other site 568708002264 Q-loop/lid; other site 568708002265 ABC transporter signature motif; other site 568708002266 Walker B; other site 568708002267 D-loop; other site 568708002268 H-loop/switch region; other site 568708002269 6 probable transmembrane helices predicted for STM_MW05311 by TMHMM2.0 at aa 21-43, 58-77, 129-151, 156-175, 246-268 and 278-300 568708002272 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 568708002273 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568708002274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708002275 Walker A/P-loop; other site 568708002276 ATP binding site [chemical binding]; other site 568708002277 Q-loop/lid; other site 568708002278 ABC transporter signature motif; other site 568708002279 Walker B; other site 568708002280 D-loop; other site 568708002281 H-loop/switch region; other site 568708002282 Signal peptide predicted for STM_MW05321 by SignalP 2.0 HMM (Signal peptide probability 0.766) with cleavage site probability 0.336 between residues 37 and 38 568708002283 4 probable transmembrane helices predicted for STM_MW05321 by TMHMM2.0 at aa 27-49, 138-160, 165-185 and 249-271 568708002286 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 568708002287 Nitrogen regulatory protein P-II; Region: P-II; smart00938 568708002289 ammonium transporter; Provisional; Region: PRK10666 568708002290 Signal peptide predicted for STM_MW05341 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.954 between residues 27 and 28 568708002291 12 probable transmembrane helices predicted for STM_MW05341 by TMHMM2.0 at aa 9-26, 36-58, 63-85, 120-142, 149-171, 186-205, 218-237, 247-269, 281-303, 307-324, 337-359 and 374-396 568708002293 acyl-CoA thioesterase II; Provisional; Region: PRK10526 568708002294 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 568708002295 active site 568708002296 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 568708002297 catalytic triad [active] 568708002298 dimer interface [polypeptide binding]; other site 568708002300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 568708002301 Signal peptide predicted for STM_MW05361 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.983 between residues 20 and 21 568708002302 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 568708002303 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 568708002304 DNA binding site [nucleotide binding] 568708002305 active site 568708002307 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 568708002308 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 568708002309 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708002310 2 probable transmembrane helices predicted for STM_MW05381 by TMHMM2.0 at aa 6-28 and 243-265 568708002312 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 568708002314 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 568708002316 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 568708002318 2 probable transmembrane helices predicted for STM_MW05411 by TMHMM2.0 at aa 36-55 and 60-79 568708002319 maltose O-acetyltransferase; Provisional; Region: PRK10092 568708002320 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 568708002321 active site 568708002322 substrate binding site [chemical binding]; other site 568708002323 trimer interface [polypeptide binding]; other site 568708002324 CoA binding site [chemical binding]; other site 568708002326 gene expression modulator; Provisional; Region: PRK10945 568708002328 Hha toxicity attenuator; Provisional; Region: PRK10667 568708002330 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 568708002331 Protein export membrane protein; Region: SecD_SecF; cl14618 568708002332 Protein export membrane protein; Region: SecD_SecF; cl14618 568708002334 11 probable transmembrane helices predicted for STM_MW05451 by TMHMM2.0 at aa 10-32, 340-359, 369-391, 438-460, 470-492, 542-564, 873-892, 899-921, 926-948, 975-997 and 1007-1029 568708002335 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 568708002336 HlyD family secretion protein; Region: HlyD_3; pfam13437 568708002338 Signal peptide predicted for STM_MW05461 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.661 between residues 24 and 25 568708002339 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 568708002340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708002341 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 568708002344 hypothetical protein; Provisional; Region: PRK11281 568708002345 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 568708002346 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 568708002347 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568708002348 Signal peptide predicted for STM_MW05481 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.835 between residues 33 and 34 568708002349 12 probable transmembrane helices predicted for STM_MW05481 by TMHMM2.0 at aa 13-32, 500-522, 557-579, 584-606, 630-647, 658-680, 693-715, 725-747, 795-817, 837-859, 880-902 and 917-939 568708002351 Uncharacterized conserved protein [Function unknown]; Region: COG5464 568708002352 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 568708002354 hypothetical protein; Provisional; Region: PRK11038 568708002356 primosomal replication protein N''; Provisional; Region: PRK10093 568708002358 hypothetical protein; Provisional; Region: PRK10527 568708002359 3 probable transmembrane helices predicted for STM_MW05521 by TMHMM2.0 at aa 5-27, 75-92 and 99-118 568708002361 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568708002362 active site 568708002364 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 568708002365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708002366 Walker A motif; other site 568708002367 ATP binding site [chemical binding]; other site 568708002368 Walker B motif; other site 568708002369 DNA polymerase III subunit delta'; Validated; Region: PRK08485 568708002370 arginine finger; other site 568708002371 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 568708002372 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 568708002373 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 568708002375 hypothetical protein; Validated; Region: PRK00153 568708002377 recombination protein RecR; Reviewed; Region: recR; PRK00076 568708002378 RecR protein; Region: RecR; pfam02132 568708002379 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 568708002380 putative active site [active] 568708002381 putative metal-binding site [ion binding]; other site 568708002382 tetramer interface [polypeptide binding]; other site 568708002385 heat shock protein 90; Provisional; Region: PRK05218 568708002386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708002387 ATP binding site [chemical binding]; other site 568708002388 Mg2+ binding site [ion binding]; other site 568708002389 G-X-G motif; other site 568708002392 adenylate kinase; Reviewed; Region: adk; PRK00279 568708002393 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 568708002394 AMP-binding site [chemical binding]; other site 568708002395 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 568708002398 ferrochelatase; Reviewed; Region: hemH; PRK00035 568708002399 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 568708002400 C-terminal domain interface [polypeptide binding]; other site 568708002401 active site 568708002402 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 568708002403 active site 568708002404 N-terminal domain interface [polypeptide binding]; other site 568708002406 acetyl esterase; Provisional; Region: PRK10162 568708002408 inosine/guanosine kinase; Provisional; Region: PRK15074 568708002409 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568708002411 putative cation:proton antiport protein; Provisional; Region: PRK10669 568708002412 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 568708002413 TrkA-N domain; Region: TrkA_N; pfam02254 568708002415 12 probable transmembrane helices predicted for STM_MW05621 by TMHMM2.0 at aa 4-26, 33-52, 56-78, 87-109, 114-136, 149-171, 191-213, 226-248, 280-299, 302-324, 339-361 and 368-387 568708002417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708002418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568708002419 putative substrate translocation pore; other site 568708002420 10 probable transmembrane helices predicted for STM_MW05631 by TMHMM2.0 at aa 26-48, 58-80, 101-123, 180-202, 223-245, 265-287, 294-313, 317-339, 351-373 and 377-399 568708002422 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 568708002423 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 568708002424 active site 568708002425 metal binding site [ion binding]; metal-binding site 568708002426 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 568708002427 Signal peptide predicted for STM_MW05641 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 25 and 26 568708002430 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 568708002431 putative deacylase active site [active] 568708002433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 568708002435 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 568708002437 Signal peptide predicted for STM_MW05671 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 19 and 20 568708002438 copper exporting ATPase; Provisional; Region: copA; PRK10671 568708002439 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568708002440 metal-binding site [ion binding] 568708002441 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568708002442 metal-binding site [ion binding] 568708002443 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568708002444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708002445 motif II; other site 568708002447 8 probable transmembrane helices predicted for STM_MW05681 by TMHMM2.0 at aa 188-205, 215-237, 244-266, 281-298, 435-457, 462-484, 777-796 and 801-823 568708002450 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 568708002451 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 568708002452 DNA binding residues [nucleotide binding] 568708002453 dimer interface [polypeptide binding]; other site 568708002454 copper binding site [ion binding]; other site 568708002457 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 568708002459 3 probable transmembrane helices predicted for STM_MW05701 by TMHMM2.0 at aa 4-23, 30-49 and 53-75 568708002460 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 568708002461 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 568708002463 1 probable transmembrane helix predicted for STM_MW05711 by TMHMM2.0 at aa 7-29 568708002464 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 568708002465 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568708002466 Walker A/P-loop; other site 568708002467 ATP binding site [chemical binding]; other site 568708002468 Q-loop/lid; other site 568708002469 ABC transporter signature motif; other site 568708002470 Walker B; other site 568708002471 D-loop; other site 568708002472 H-loop/switch region; other site 568708002474 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 568708002475 Signal peptide predicted for STM_MW05731 by SignalP 2.0 HMM (Signal peptide probability 0.824) with cleavage site probability 0.719 between residues 27 and 28 568708002477 6 probable transmembrane helices predicted for STM_MW05731 by TMHMM2.0 at aa 7-24, 57-79, 92-114, 118-140, 192-209 and 219-241 568708002478 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 568708002479 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 568708002481 oxidoreductase; Provisional; Region: PRK08017 568708002482 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 568708002483 NADP binding site [chemical binding]; other site 568708002484 active site 568708002485 steroid binding site; other site 568708002487 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 568708002488 active site 568708002489 catalytic triad [active] 568708002490 oxyanion hole [active] 568708002491 switch loop; other site 568708002493 1 probable transmembrane helix predicted for STM_MW05761 by TMHMM2.0 at aa 7-26 568708002494 Signal peptide predicted for STM_MW05761 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.788 between residues 25 and 26 568708002495 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 568708002496 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568708002497 Walker A/P-loop; other site 568708002498 ATP binding site [chemical binding]; other site 568708002499 Q-loop/lid; other site 568708002500 ABC transporter signature motif; other site 568708002501 Walker B; other site 568708002502 D-loop; other site 568708002503 H-loop/switch region; other site 568708002505 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 568708002506 FtsX-like permease family; Region: FtsX; pfam02687 568708002507 Signal peptide predicted for STM_MW05781 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.640 between residues 33 and 34 568708002508 10 probable transmembrane helices predicted for STM_MW05781 by TMHMM2.0 at aa 13-35, 243-262, 291-313, 333-355, 376-398, 403-425, 451-473, 676-698, 732-754 and 769-791 568708002510 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568708002511 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 568708002512 Signal peptide predicted for STM_MW05791 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.899 between residues 25 and 26 568708002513 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 568708002514 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568708002515 Signal peptide predicted for STM_MW05801 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 25 and 26 568708002517 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 568708002518 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 568708002519 Walker A/P-loop; other site 568708002520 ATP binding site [chemical binding]; other site 568708002521 Q-loop/lid; other site 568708002522 ABC transporter signature motif; other site 568708002523 Walker B; other site 568708002524 D-loop; other site 568708002525 H-loop/switch region; other site 568708002526 NIL domain; Region: NIL; pfam09383 568708002529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708002530 dimer interface [polypeptide binding]; other site 568708002531 conserved gate region; other site 568708002532 ABC-ATPase subunit interface; other site 568708002533 6 probable transmembrane helices predicted for STM_MW05821 by TMHMM2.0 at aa 15-37, 50-72, 82-104, 117-139, 149-171 and 183-205 568708002535 Predicted ATPase [General function prediction only]; Region: COG2603 568708002536 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 568708002537 active site residue [active] 568708002539 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 568708002540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708002541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568708002542 dimerization interface [polypeptide binding]; other site 568708002545 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 568708002546 ureidoglycolate hydrolase; Provisional; Region: PRK03606 568708002548 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 568708002549 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568708002550 Bacterial transcriptional regulator; Region: IclR; pfam01614 568708002553 glyoxylate carboligase; Provisional; Region: PRK11269 568708002554 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568708002555 PYR/PP interface [polypeptide binding]; other site 568708002556 dimer interface [polypeptide binding]; other site 568708002557 TPP binding site [chemical binding]; other site 568708002558 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568708002559 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 568708002560 TPP-binding site [chemical binding]; other site 568708002564 hydroxypyruvate isomerase; Provisional; Region: PRK09997 568708002566 tartronate semialdehyde reductase; Provisional; Region: PRK15059 568708002567 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568708002569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708002570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568708002571 putative substrate translocation pore; other site 568708002572 12 probable transmembrane helices predicted for STM_MW05901 by TMHMM2.0 at aa 21-40, 55-77, 84-101, 106-128, 141-163, 173-195, 223-245, 260-282, 295-313, 323-342, 355-377 and 387-406 568708002576 putative uracil/xanthine transporter; Provisional; Region: PRK11412 568708002578 11 probable transmembrane helices predicted for STM_MW05921 by TMHMM2.0 at aa 15-37, 42-64, 99-121, 128-150, 170-189, 196-213, 237-259, 280-302, 341-363, 375-397 and 407-426 568708002579 glycerate kinase II; Provisional; Region: PRK09932 568708002581 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 568708002582 Mif2/CENP-C like; Region: Mif2; pfam11699 568708002583 Cupin domain; Region: Cupin_2; pfam07883 568708002586 allantoate amidohydrolase; Region: AllC; TIGR03176 568708002587 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 568708002588 active site 568708002589 metal binding site [ion binding]; metal-binding site 568708002590 dimer interface [polypeptide binding]; other site 568708002593 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 568708002595 membrane protein FdrA; Validated; Region: PRK06091 568708002596 CoA binding domain; Region: CoA_binding; pfam02629 568708002597 CoA-ligase; Region: Ligase_CoA; pfam00549 568708002600 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 568708002602 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 568708002604 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 568708002605 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 568708002606 putative substrate binding site [chemical binding]; other site 568708002607 nucleotide binding site [chemical binding]; other site 568708002608 nucleotide binding site [chemical binding]; other site 568708002609 homodimer interface [polypeptide binding]; other site 568708002611 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 568708002612 ATP-grasp domain; Region: ATP-grasp; pfam02222 568708002614 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 568708002616 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 568708002617 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568708002618 putative active site [active] 568708002619 putative metal binding site [ion binding]; other site 568708002621 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 568708002622 substrate binding site [chemical binding]; other site 568708002624 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 568708002625 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568708002626 active site 568708002627 HIGH motif; other site 568708002628 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568708002629 KMSKS motif; other site 568708002630 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 568708002631 tRNA binding surface [nucleotide binding]; other site 568708002632 anticodon binding site; other site 568708002635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 568708002636 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 568708002638 Signal peptide predicted for STM_MW06061 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 568708002639 Signal peptide predicted for STM_MW06071 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.971 between residues 21 and 22 568708002640 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 568708002641 4 probable transmembrane helices predicted for STM_MW06081 by TMHMM2.0 at aa 12-34, 54-76, 89-108 and 149-171 568708002643 ribosome-associated protein; Provisional; Region: PRK11507 568708002644 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 568708002645 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 568708002646 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 568708002647 homodimer interface [polypeptide binding]; other site 568708002648 NADP binding site [chemical binding]; other site 568708002649 substrate binding site [chemical binding]; other site 568708002652 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 568708002653 Signal peptide predicted for STM_MW06111 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 22 and 23 568708002655 fimbrial protein FimI; Provisional; Region: PRK15200 568708002656 Signal peptide predicted for STM_MW06121 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 19 and 20 568708002658 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 568708002659 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708002660 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708002661 Signal peptide predicted for STM_MW06131 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 568708002662 1 probable transmembrane helix predicted for STM_MW06131 by TMHMM2.0 at aa 7-29 568708002665 outer membrane usher protein FimD; Provisional; Region: PRK15198 568708002666 PapC N-terminal domain; Region: PapC_N; pfam13954 568708002667 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568708002668 PapC C-terminal domain; Region: PapC_C; pfam13953 568708002669 Signal peptide predicted for STM_MW06141 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.471 between residues 27 and 28 568708002671 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 568708002672 Signal peptide predicted for STM_MW06151 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 22 and 23 568708002673 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 568708002674 Signal peptide predicted for STM_MW06161 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 21 and 22 568708002676 transcriptional regulator FimZ; Provisional; Region: PRK09935 568708002677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708002678 active site 568708002679 phosphorylation site [posttranslational modification] 568708002680 intermolecular recognition site; other site 568708002681 dimerization interface [polypeptide binding]; other site 568708002682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708002683 DNA binding residues [nucleotide binding] 568708002684 dimerization interface [polypeptide binding]; other site 568708002687 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 568708002688 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708002689 DNA binding residues [nucleotide binding] 568708002690 dimerization interface [polypeptide binding]; other site 568708002694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568708002695 Transposase; Region: HTH_Tnp_1; pfam01527 568708002697 9 probable transmembrane helices predicted for STM_MW06231 by TMHMM2.0 at aa 13-32, 77-96, 108-130, 135-157, 201-223, 254-273, 280-302, 307-329 and 336-358 568708002698 Signal peptide predicted for STM_MW06231 by SignalP 2.0 HMM (Signal peptide probability 0.879) with cleavage site probability 0.554 between residues 27 and 28 568708002699 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 568708002700 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 568708002701 Ligand binding site; other site 568708002702 Putative Catalytic site; other site 568708002703 DXD motif; other site 568708002705 2 probable transmembrane helices predicted for STM_MW06241 by TMHMM2.0 at aa 227-249 and 264-286 568708002706 Predicted membrane protein [Function unknown]; Region: COG2246 568708002707 GtrA-like protein; Region: GtrA; pfam04138 568708002708 4 probable transmembrane helices predicted for STM_MW06251 by TMHMM2.0 at aa 12-31, 35-54, 67-84 and 94-116 568708002714 Cupin; Region: Cupin_6; pfam12852 568708002715 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 568708002716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708002717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708002719 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 568708002720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568708002721 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568708002725 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 568708002726 Signal peptide predicted for STM_MW06301 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 22 and 23 568708002728 Predicted membrane protein [Function unknown]; Region: COG3059 568708002730 4 probable transmembrane helices predicted for STM_MW06311 by TMHMM2.0 at aa 13-32, 87-106, 113-135 and 164-183 568708002731 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 568708002732 phenylalanine transporter; Provisional; Region: PRK10249 568708002734 12 probable transmembrane helices predicted for STM_MW06331 by TMHMM2.0 at aa 34-53, 57-74, 107-129, 139-161, 166-188, 210-232, 253-275, 295-317, 344-366, 370-392, 413-435 and 440-459 568708002735 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 568708002736 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568708002738 5 probable transmembrane helices predicted for STM_MW06341 by TMHMM2.0 at aa 21-43, 72-89, 102-124, 139-161 and 166-183 568708002739 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 568708002740 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 568708002741 active site 568708002742 oxyanion hole [active] 568708002743 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 568708002744 catalytic triad [active] 568708002745 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 568708002746 Signal peptide predicted for STM_MW06351 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 25 and 26 568708002749 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 568708002750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708002751 ATP binding site [chemical binding]; other site 568708002752 Walker B motif; other site 568708002753 arginine finger; other site 568708002754 Transcriptional antiterminator [Transcription]; Region: COG3933 568708002755 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568708002756 active pocket/dimerization site; other site 568708002757 active site 568708002758 phosphorylation site [posttranslational modification] 568708002759 PRD domain; Region: PRD; pfam00874 568708002760 Signal peptide predicted for STM_MW06361 by SignalP 2.0 HMM (Signal peptide probability 0.933) with cleavage site probability 0.457 between residues 31 and 32 568708002764 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 568708002765 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 568708002766 putative active site [active] 568708002767 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 568708002768 dimer interface [polypeptide binding]; other site 568708002769 active site 568708002771 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 568708002772 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568708002773 dimer interface [polypeptide binding]; other site 568708002774 active site 568708002775 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 568708002776 dimer interface [polypeptide binding]; other site 568708002777 active site 568708002779 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 568708002780 4 probable transmembrane helices predicted for STM_MW06391 by TMHMM2.0 at aa 152-174, 195-217, 237-254 and 261-283 568708002782 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 568708002784 6 probable transmembrane helices predicted for STM_MW06401 by TMHMM2.0 at aa 7-29, 34-56, 69-91, 124-146, 153-175 and 190-212 568708002785 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 568708002786 active site 568708002787 phosphorylation site [posttranslational modification] 568708002789 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568708002790 active pocket/dimerization site; other site 568708002791 active site 568708002792 phosphorylation site [posttranslational modification] 568708002794 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 568708002795 dimer interface [polypeptide binding]; other site 568708002796 FMN binding site [chemical binding]; other site 568708002798 hypothetical protein; Provisional; Region: PRK10250 568708002800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568708002801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708002803 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 568708002804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708002806 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 568708002808 2 probable transmembrane helices predicted for STM_MW06472 by TMHMM2.0 at aa 13-35 and 50-72 568708002809 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 568708002810 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 568708002812 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 568708002813 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 568708002815 outer membrane receptor FepA; Provisional; Region: PRK13524 568708002816 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568708002817 N-terminal plug; other site 568708002818 ligand-binding site [chemical binding]; other site 568708002821 Signal peptide predicted for STM_MW06501 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 25 and 26 568708002822 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 568708002823 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 568708002824 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 568708002826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 568708002828 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 568708002829 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 568708002830 acyl-activating enzyme (AAE) consensus motif; other site 568708002831 AMP binding site [chemical binding]; other site 568708002832 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 568708002837 LPS O-antigen length regulator; Provisional; Region: PRK10381 568708002838 Chain length determinant protein; Region: Wzz; pfam02706 568708002840 2 probable transmembrane helices predicted for STM_MW06541 by TMHMM2.0 at aa 43-62 and 338-360 568708002841 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 568708002842 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 568708002843 Walker A/P-loop; other site 568708002844 ATP binding site [chemical binding]; other site 568708002845 Q-loop/lid; other site 568708002846 ABC transporter signature motif; other site 568708002847 Walker B; other site 568708002848 D-loop; other site 568708002849 H-loop/switch region; other site 568708002851 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 568708002852 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568708002853 ABC-ATPase subunit interface; other site 568708002854 dimer interface [polypeptide binding]; other site 568708002855 putative PBP binding regions; other site 568708002856 8 probable transmembrane helices predicted for STM_MW06561 by TMHMM2.0 at aa 7-26, 57-79, 92-111, 115-137, 144-166, 193-210, 239-261 and 301-323 568708002858 Signal peptide predicted for STM_MW06561 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.876 between residues 30 and 31 568708002859 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 568708002860 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568708002861 ABC-ATPase subunit interface; other site 568708002862 dimer interface [polypeptide binding]; other site 568708002863 putative PBP binding regions; other site 568708002864 9 probable transmembrane helices predicted for STM_MW06571 by TMHMM2.0 at aa 10-32, 65-82, 92-114, 121-140, 155-177, 198-220, 240-262, 282-304 and 308-326 568708002866 Signal peptide predicted for STM_MW06571 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.811 between residues 32 and 33 568708002867 enterobactin exporter EntS; Provisional; Region: PRK10489 568708002868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708002869 putative substrate translocation pore; other site 568708002871 12 probable transmembrane helices predicted for STM_MW06581 by TMHMM2.0 at aa 22-44, 54-76, 83-105, 110-132, 153-175, 179-201, 214-236, 256-278, 285-307, 312-331, 351-373 and 377-399 568708002872 ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592 568708002873 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 568708002874 siderophore binding site; other site 568708002876 Signal peptide predicted for STM_MW06591 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 24 and 25 568708002877 isochorismate synthase EntC; Provisional; Region: PRK15016 568708002878 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 568708002880 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 568708002881 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 568708002882 acyl-activating enzyme (AAE) consensus motif; other site 568708002883 active site 568708002884 AMP binding site [chemical binding]; other site 568708002885 substrate binding site [chemical binding]; other site 568708002887 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 568708002888 hydrophobic substrate binding pocket; other site 568708002889 Isochorismatase family; Region: Isochorismatase; pfam00857 568708002890 active site 568708002891 conserved cis-peptide bond; other site 568708002892 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 568708002895 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 568708002896 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 568708002897 putative NAD(P) binding site [chemical binding]; other site 568708002898 active site 568708002900 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568708002901 CoenzymeA binding site [chemical binding]; other site 568708002902 subunit interaction site [polypeptide binding]; other site 568708002903 PHB binding site; other site 568708002905 carbon starvation protein A; Provisional; Region: PRK15015 568708002906 Carbon starvation protein CstA; Region: CstA; pfam02554 568708002907 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 568708002908 Signal peptide predicted for STM_MW06651 by SignalP 2.0 HMM (Signal peptide probability 0.919) with cleavage site probability 0.540 between residues 22 and 23 568708002909 18 probable transmembrane helices predicted for STM_MW06651 by TMHMM2.0 at aa 7-26, 32-54, 89-111, 116-138, 159-181, 191-213, 218-240, 255-277, 284-306, 326-348, 361-383, 398-420, 441-463, 468-487, 514-533, 548-570, 577-599 and 649-671 568708002911 Uncharacterized small protein [Function unknown]; Region: COG2879 568708002913 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 568708002914 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 568708002915 putative active site [active] 568708002916 metal binding site [ion binding]; metal-binding site 568708002918 methionine aminotransferase; Validated; Region: PRK09082 568708002919 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568708002920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708002921 homodimer interface [polypeptide binding]; other site 568708002922 catalytic residue [active] 568708002923 Signal peptide predicted for STM_MW06681 by SignalP 2.0 HMM (Signal peptide probability 0.626) with cleavage site probability 0.422 between residues 27 and 28 568708002925 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 568708002926 ParB-like nuclease domain; Region: ParBc; pfam02195 568708002928 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 568708002929 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 568708002930 Active Sites [active] 568708002931 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 568708002933 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 568708002934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708002935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568708002936 dimerization interface [polypeptide binding]; other site 568708002939 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 568708002940 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 568708002941 dimerization domain [polypeptide binding]; other site 568708002942 dimer interface [polypeptide binding]; other site 568708002943 catalytic residues [active] 568708002944 Signal peptide predicted for STM_MW06721 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 17 and 18 568708002945 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 568708002946 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 568708002947 dimer interface [polypeptide binding]; other site 568708002948 decamer (pentamer of dimers) interface [polypeptide binding]; other site 568708002949 catalytic triad [active] 568708002950 peroxidatic and resolving cysteines [active] 568708002953 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 568708002954 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 568708002955 catalytic residue [active] 568708002956 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 568708002957 catalytic residues [active] 568708002958 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568708002959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568708002962 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 568708002964 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 568708002965 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 568708002966 putative [4Fe-4S] binding site [ion binding]; other site 568708002967 putative molybdopterin cofactor binding site [chemical binding]; other site 568708002968 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 568708002969 molybdopterin cofactor binding site; other site 568708002970 Signal peptide predicted for STM_MW06761 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 38 and 39 568708002971 1 probable transmembrane helix predicted for STM_MW06761 by TMHMM2.0 at aa 13-32 568708002975 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 568708002976 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 568708002978 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 568708002980 8 probable transmembrane helices predicted for STM_MW06781 by TMHMM2.0 at aa 5-27, 39-61, 76-95, 102-124, 134-156, 163-185, 195-214 and 226-248 568708002981 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568708002982 Ligand Binding Site [chemical binding]; other site 568708002984 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 568708002985 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 568708002986 NAD binding site [chemical binding]; other site 568708002987 catalytic Zn binding site [ion binding]; other site 568708002988 structural Zn binding site [ion binding]; other site 568708002991 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 568708002992 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568708002994 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 568708002995 B1 nucleotide binding pocket [chemical binding]; other site 568708002996 B2 nucleotide binding pocket [chemical binding]; other site 568708002997 CAS motifs; other site 568708002998 active site 568708003000 Signal peptide predicted for STM_MW06821 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24 568708003001 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 568708003002 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 568708003003 transmembrane helices; other site 568708003004 13 probable transmembrane helices predicted for STM_MW06831 by TMHMM2.0 at aa 7-24, 34-53, 58-75, 95-117, 138-157, 198-220, 233-255, 288-305, 307-329, 339-361, 374-396, 428-450 and 463-485 568708003006 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 568708003008 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 568708003010 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 568708003011 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 568708003013 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 568708003015 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 568708003017 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 568708003018 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 568708003019 putative active site [active] 568708003020 (T/H)XGH motif; other site 568708003022 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 568708003023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568708003024 putative active site [active] 568708003025 heme pocket [chemical binding]; other site 568708003026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708003027 ATP binding site [chemical binding]; other site 568708003028 Mg2+ binding site [ion binding]; other site 568708003029 G-X-G motif; other site 568708003030 Signal peptide predicted for STM_MW06901 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.927 between residues 38 and 39 568708003031 2 probable transmembrane helices predicted for STM_MW06901 by TMHMM2.0 at aa 20-42 and 180-202 568708003034 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 568708003035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708003036 active site 568708003037 phosphorylation site [posttranslational modification] 568708003038 intermolecular recognition site; other site 568708003039 dimerization interface [polypeptide binding]; other site 568708003040 Transcriptional regulator; Region: CitT; pfam12431 568708003042 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 568708003043 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 568708003045 10 probable transmembrane helices predicted for STM_MW06921 by TMHMM2.0 at aa 37-59, 80-102, 117-139, 152-174, 194-216, 223-245, 265-287, 299-321, 363-385 and 392-414 568708003046 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 568708003047 Signal peptide predicted for STM_MW06931 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.962 between residues 29 and 30 568708003048 1 probable transmembrane helix predicted for STM_MW06931 by TMHMM2.0 at aa 7-29 568708003050 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568708003051 DNA-binding site [nucleotide binding]; DNA binding site 568708003052 RNA-binding motif; other site 568708003054 chromosome condensation membrane protein; Provisional; Region: PRK14196 568708003056 4 probable transmembrane helices predicted for STM_MW06951 by TMHMM2.0 at aa 5-22, 32-54, 67-89 and 99-121 568708003057 Predicted amidohydrolase [General function prediction only]; Region: COG0388 568708003058 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 568708003059 putative active site [active] 568708003060 catalytic triad [active] 568708003061 putative dimer interface [polypeptide binding]; other site 568708003063 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 568708003064 1 probable transmembrane helix predicted for STM_MW06971 by TMHMM2.0 at aa 4-21 568708003066 lipoyl synthase; Provisional; Region: PRK05481 568708003067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708003068 FeS/SAM binding site; other site 568708003070 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 568708003071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708003072 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 568708003073 substrate binding pocket [chemical binding]; other site 568708003074 dimerization interface [polypeptide binding]; other site 568708003077 lipoate-protein ligase B; Provisional; Region: PRK14342 568708003079 hypothetical protein; Provisional; Region: PRK04998 568708003081 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 568708003082 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 568708003083 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 568708003086 Signal peptide predicted for STM_MW07021 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 29 and 30 568708003087 rare lipoprotein A; Provisional; Region: PRK10672 568708003088 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 568708003089 Sporulation related domain; Region: SPOR; pfam05036 568708003092 Signal peptide predicted for STM_MW07031 by SignalP 2.0 HMM (Signal peptide probability 0.967) with cleavage site probability 0.505 between residues 25 and 26 568708003093 cell wall shape-determining protein; Provisional; Region: PRK10794 568708003094 9 probable transmembrane helices predicted for STM_MW07041 by TMHMM2.0 at aa 15-37, 50-67, 77-99, 136-155, 160-179, 181-203, 272-294, 306-328 and 338-360 568708003096 Signal peptide predicted for STM_MW07041 by SignalP 2.0 HMM (Signal peptide probability 0.957) with cleavage site probability 0.604 between residues 40 and 41 568708003097 penicillin-binding protein 2; Provisional; Region: PRK10795 568708003098 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568708003099 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568708003102 1 probable transmembrane helix predicted for STM_MW07051 by TMHMM2.0 at aa 21-43 568708003103 Signal peptide predicted for STM_MW07051 by SignalP 2.0 HMM (Signal peptide probability 0.673) with cleavage site probability 0.546 between residues 37 and 38 568708003104 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 568708003106 ribosome-associated protein; Provisional; Region: PRK11538 568708003108 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568708003109 catalytic core [active] 568708003111 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 568708003112 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568708003113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708003114 homodimer interface [polypeptide binding]; other site 568708003115 catalytic residue [active] 568708003117 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 568708003118 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 568708003119 active site 568708003120 (T/H)XGH motif; other site 568708003122 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 568708003123 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 568708003125 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 568708003127 Signal peptide predicted for STM_MW07121 by SignalP 2.0 HMM (Signal peptide probability 0.810) with cleavage site probability 0.253 between residues 27 and 28 568708003128 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 568708003129 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 568708003130 HIGH motif; other site 568708003131 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568708003132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568708003133 active site 568708003134 KMSKS motif; other site 568708003135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 568708003136 tRNA binding surface [nucleotide binding]; other site 568708003139 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 568708003141 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 568708003143 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 568708003145 8 probable transmembrane helices predicted for STM_MW07161 by TMHMM2.0 at aa 7-25, 35-57, 70-92, 157-179, 192-211, 216-238, 247-269 and 279-301 568708003146 Propionate catabolism activator; Region: PrpR_N; pfam06506 568708003147 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 568708003148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708003149 Walker A motif; other site 568708003150 ATP binding site [chemical binding]; other site 568708003151 Walker B motif; other site 568708003152 arginine finger; other site 568708003153 Signal peptide predicted for STM_MW07171 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.960 between residues 24 and 25 568708003156 hypothetical protein; Provisional; Region: PRK11032 568708003157 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 568708003159 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 568708003160 Sel1-like repeats; Region: SEL1; smart00671 568708003161 Sel1-like repeats; Region: SEL1; smart00671 568708003162 Sel1-like repeats; Region: SEL1; smart00671 568708003163 Sel1-like repeats; Region: SEL1; smart00671 568708003164 Sel1-like repeats; Region: SEL1; smart00671 568708003166 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 568708003168 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 568708003169 HSP70 interaction site [polypeptide binding]; other site 568708003171 1 probable transmembrane helix predicted for STM_MW07211 by TMHMM2.0 at aa 453-472 568708003172 Note the frameshift mutation following codon 46; pfam_scan;Pfam:PF06889; E()=8.6E-120;score=397.7;query 1-231;description=DUF1266 568708003174 DnaJ domain; Region: DnaJ; pfam00226 568708003175 HSP70 interaction site [polypeptide binding]; other site 568708003177 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 568708003178 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 568708003179 nucleotide binding site [chemical binding]; other site 568708003180 putative NEF/HSP70 interaction site [polypeptide binding]; other site 568708003181 SBD interface [polypeptide binding]; other site 568708003183 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 568708003184 active site 568708003185 tetramer interface [polypeptide binding]; other site 568708003187 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568708003188 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568708003189 Walker A/P-loop; other site 568708003190 ATP binding site [chemical binding]; other site 568708003191 Q-loop/lid; other site 568708003192 ABC transporter signature motif; other site 568708003193 Walker B; other site 568708003194 D-loop; other site 568708003195 H-loop/switch region; other site 568708003197 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568708003198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708003199 dimer interface [polypeptide binding]; other site 568708003200 conserved gate region; other site 568708003201 putative PBP binding loops; other site 568708003202 ABC-ATPase subunit interface; other site 568708003203 5 probable transmembrane helices predicted for STM_MW07281 by TMHMM2.0 at aa 15-37, 58-80, 95-112, 155-177 and 197-219 568708003205 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568708003206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708003207 dimer interface [polypeptide binding]; other site 568708003208 conserved gate region; other site 568708003209 putative PBP binding loops; other site 568708003210 ABC-ATPase subunit interface; other site 568708003211 5 probable transmembrane helices predicted for STM_MW07291 by TMHMM2.0 at aa 31-53, 66-88, 108-127, 179-196 and 211-233 568708003213 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 568708003214 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568708003215 substrate binding pocket [chemical binding]; other site 568708003216 membrane-bound complex binding site; other site 568708003217 hinge residues; other site 568708003219 Signal peptide predicted for STM_MW07301 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 28 and 29 568708003220 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 568708003221 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 568708003222 putative active site [active] 568708003223 catalytic triad [active] 568708003224 putative dimer interface [polypeptide binding]; other site 568708003225 8 probable transmembrane helices predicted for STM_MW07311 by TMHMM2.0 at aa 12-29, 33-50, 57-79, 89-111, 124-146, 166-188, 195-213 and 489-507 568708003227 Signal peptide predicted for STM_MW07311 by SignalP 2.0 HMM (Signal peptide probability 0.892) with cleavage site probability 0.839 between residues 27 and 28 568708003228 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 568708003229 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568708003230 Transporter associated domain; Region: CorC_HlyC; smart01091 568708003233 metal-binding heat shock protein; Provisional; Region: PRK00016 568708003235 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 568708003236 PhoH-like protein; Region: PhoH; pfam02562 568708003238 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 568708003239 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 568708003240 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708003241 FeS/SAM binding site; other site 568708003242 TRAM domain; Region: TRAM; pfam01938 568708003246 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 568708003247 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568708003249 1 probable transmembrane helix predicted for STM_MW07361 by TMHMM2.0 at aa 7-29 568708003250 4 probable transmembrane helices predicted for STM_MW07371 by TMHMM2.0 at aa 7-28, 33-55, 99-121 and 131-153 568708003251 Signal peptide predicted for STM_MW07371 by SignalP 2.0 HMM (Signal peptide probability 0.730) with cleavage site probability 0.565 between residues 34 and 35 568708003252 asparagine synthetase B; Provisional; Region: asnB; PRK09431 568708003253 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 568708003254 active site 568708003255 dimer interface [polypeptide binding]; other site 568708003256 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 568708003257 Ligand Binding Site [chemical binding]; other site 568708003258 Molecular Tunnel; other site 568708003260 UMP phosphatase; Provisional; Region: PRK10444 568708003261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708003262 active site 568708003263 motif I; other site 568708003264 motif II; other site 568708003265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708003267 MarR family; Region: MarR; pfam01047 568708003268 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568708003269 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568708003270 nucleotide binding site [chemical binding]; other site 568708003273 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 568708003274 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 568708003275 active site 568708003276 dimer interface [polypeptide binding]; other site 568708003278 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 568708003279 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 568708003280 active site 568708003281 trimer interface [polypeptide binding]; other site 568708003282 allosteric site; other site 568708003283 active site lid [active] 568708003284 hexamer (dimer of trimers) interface [polypeptide binding]; other site 568708003286 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 568708003287 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568708003288 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568708003289 active site turn [active] 568708003290 phosphorylation site [posttranslational modification] 568708003291 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 568708003292 HPr interaction site; other site 568708003293 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568708003294 active site 568708003295 phosphorylation site [posttranslational modification] 568708003297 11 probable transmembrane helices predicted for STM_MW07431 by TMHMM2.0 at aa 13-30, 40-62, 69-91, 96-118, 131-153, 163-185, 192-214, 229-251, 258-280, 295-317 and 337-359 568708003300 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 568708003301 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568708003302 active site 568708003303 HIGH motif; other site 568708003304 nucleotide binding site [chemical binding]; other site 568708003305 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 568708003306 KMSKS motif; other site 568708003307 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 568708003310 outer membrane porin, OprD family; Region: OprD; pfam03573 568708003311 Signal peptide predicted for STM_MW07451 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.848 between residues 32 and 33 568708003312 1 probable transmembrane helix predicted for STM_MW07451 by TMHMM2.0 at aa 9-28 568708003314 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 568708003315 YbfN-like lipoprotein; Region: YbfN; pfam13982 568708003316 Signal peptide predicted for STM_MW07461 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.944 between residues 18 and 19 568708003317 citrate-proton symporter; Provisional; Region: PRK15075 568708003318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708003319 putative substrate translocation pore; other site 568708003320 12 probable transmembrane helices predicted for STM_MW07471 by TMHMM2.0 at aa 20-42, 57-79, 88-110, 120-142, 163-185, 189-211, 239-261, 276-298, 305-327, 337-356, 369-391 and 401-423 568708003322 tricarballylate utilization protein B; Provisional; Region: PRK15033 568708003323 6 probable transmembrane helices predicted for STM_MW07481 by TMHMM2.0 at aa 112-134, 154-176, 230-252, 262-284, 305-322 and 327-349 568708003324 tricarballylate dehydrogenase; Validated; Region: PRK08274 568708003325 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568708003327 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708003328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708003329 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 568708003330 putative dimerization interface [polypeptide binding]; other site 568708003333 ferric uptake regulator; Provisional; Region: fur; PRK09462 568708003334 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568708003335 metal binding site 2 [ion binding]; metal-binding site 568708003336 putative DNA binding helix; other site 568708003337 metal binding site 1 [ion binding]; metal-binding site 568708003338 dimer interface [polypeptide binding]; other site 568708003339 structural Zn2+ binding site [ion binding]; other site 568708003341 flavodoxin FldA; Validated; Region: PRK09267 568708003343 LexA regulated protein; Provisional; Region: PRK11675 568708003345 acyl-CoA esterase; Provisional; Region: PRK10673 568708003346 PGAP1-like protein; Region: PGAP1; pfam07819 568708003348 replication initiation regulator SeqA; Provisional; Region: PRK11187 568708003350 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 568708003351 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 568708003352 active site 568708003353 substrate binding site [chemical binding]; other site 568708003354 metal binding site [ion binding]; metal-binding site 568708003359 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 568708003361 putrescine transporter; Provisional; Region: potE; PRK10655 568708003362 12 probable transmembrane helices predicted for STM_MW07581 by TMHMM2.0 at aa 9-31, 37-59, 89-111, 121-143, 150-172, 187-206, 227-249, 269-291, 325-342, 352-374, 387-405 and 410-429 568708003364 ornithine decarboxylase; Provisional; Region: PRK13578 568708003365 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 568708003366 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 568708003367 homodimer interface [polypeptide binding]; other site 568708003368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708003369 catalytic residue [active] 568708003370 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 568708003374 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 568708003375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708003376 active site 568708003377 phosphorylation site [posttranslational modification] 568708003378 intermolecular recognition site; other site 568708003379 dimerization interface [polypeptide binding]; other site 568708003380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708003381 DNA binding site [nucleotide binding] 568708003384 sensor protein KdpD; Provisional; Region: PRK10490 568708003385 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 568708003386 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 568708003387 Ligand Binding Site [chemical binding]; other site 568708003388 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 568708003389 GAF domain; Region: GAF_3; pfam13492 568708003390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708003391 dimer interface [polypeptide binding]; other site 568708003392 phosphorylation site [posttranslational modification] 568708003393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708003394 ATP binding site [chemical binding]; other site 568708003395 Mg2+ binding site [ion binding]; other site 568708003396 G-X-G motif; other site 568708003399 3 probable transmembrane helices predicted for STM_MW07611 by TMHMM2.0 at aa 399-421, 428-450 and 476-498 568708003402 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 568708003404 1 probable transmembrane helix predicted for STM_MW07621 by TMHMM2.0 at aa 12-34 568708003405 Signal peptide predicted for STM_MW07621 by SignalP 2.0 HMM (Signal peptide probability 0.916) with cleavage site probability 0.662 between residues 28 and 29 568708003406 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 568708003407 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568708003408 7 probable transmembrane helices predicted for STM_MW07631 by TMHMM2.0 at aa 37-59, 63-85, 220-242, 252-274, 578-600, 615-634 and 654-676 568708003411 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 568708003413 12 probable transmembrane helices predicted for STM_MW07641 by TMHMM2.0 at aa 5-27, 62-84, 130-152, 173-195, 253-275, 282-301, 325-347, 354-376, 380-399, 419-438, 483-505 and 526-548 568708003414 Signal peptide predicted for STM_MW07641 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.975 between residues 20 and 21 568708003415 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 568708003417 1 probable transmembrane helix predicted for STM_MW07651 by TMHMM2.0 at aa 12-33 568708003418 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 568708003419 DNA photolyase; Region: DNA_photolyase; pfam00875 568708003422 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 568708003423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708003424 putative substrate translocation pore; other site 568708003425 POT family; Region: PTR2; pfam00854 568708003426 14 probable transmembrane helices predicted for STM_MW07671 by TMHMM2.0 at aa 13-35, 50-67, 72-94, 98-117, 138-157, 167-189, 209-231, 235-254, 267-284, 310-332, 344-366, 376-398, 410-432 and 462-479 568708003428 Uncharacterized conserved protein [Function unknown]; Region: COG0327 568708003429 metal-binding protein; Provisional; Region: PRK10799 568708003431 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 568708003432 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 568708003434 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 568708003436 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 568708003437 putative active site [active] 568708003439 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568708003440 active site 568708003441 DNA binding site [nucleotide binding] 568708003442 Int/Topo IB signature motif; other site 568708003444 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 568708003445 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568708003446 UDP-galactopyranose mutase; Region: GLF; pfam03275 568708003447 Signal peptide predicted for STM_MW07761 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.536 between residues 19 and 20 568708003450 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 568708003451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568708003452 active site 568708003454 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 568708003455 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568708003456 putative ADP-binding pocket [chemical binding]; other site 568708003458 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 568708003459 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 568708003461 6 probable transmembrane helices predicted for STM_MW07791 by TMHMM2.0 at aa 29-51, 66-88, 108-130, 140-162, 169-188 and 224-246 568708003462 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 568708003463 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 568708003464 Walker A/P-loop; other site 568708003465 ATP binding site [chemical binding]; other site 568708003466 Q-loop/lid; other site 568708003467 ABC transporter signature motif; other site 568708003468 Walker B; other site 568708003469 D-loop; other site 568708003470 H-loop/switch region; other site 568708003472 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 568708003473 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568708003474 active site 568708003476 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568708003477 active site 568708003479 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 568708003480 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 568708003481 endonuclease VIII; Provisional; Region: PRK10445 568708003482 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 568708003483 DNA binding site [nucleotide binding] 568708003484 catalytic residue [active] 568708003485 putative catalytic residues [active] 568708003486 H2TH interface [polypeptide binding]; other site 568708003487 intercalation triad [nucleotide binding]; other site 568708003488 substrate specificity determining residue; other site 568708003489 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 568708003490 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568708003494 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 568708003495 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 568708003496 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 568708003498 6 probable transmembrane helices predicted for STM_MW07861 by TMHMM2.0 at aa 21-43, 53-75, 116-135, 145-167, 234-256 and 289-311 568708003499 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 568708003500 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 568708003501 dimer interface [polypeptide binding]; other site 568708003502 active site 568708003503 citrylCoA binding site [chemical binding]; other site 568708003504 NADH binding [chemical binding]; other site 568708003505 cationic pore residues; other site 568708003506 oxalacetate/citrate binding site [chemical binding]; other site 568708003507 coenzyme A binding site [chemical binding]; other site 568708003508 catalytic triad [active] 568708003510 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 568708003511 Iron-sulfur protein interface; other site 568708003512 proximal quinone binding site [chemical binding]; other site 568708003513 SdhD (CybS) interface [polypeptide binding]; other site 568708003514 proximal heme binding site [chemical binding]; other site 568708003516 3 probable transmembrane helices predicted for STM_MW07891 by TMHMM2.0 at aa 27-49, 69-88 and 109-128 568708003517 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 568708003518 SdhC subunit interface [polypeptide binding]; other site 568708003519 proximal heme binding site [chemical binding]; other site 568708003520 cardiolipin binding site; other site 568708003521 Iron-sulfur protein interface; other site 568708003522 proximal quinone binding site [chemical binding]; other site 568708003524 3 probable transmembrane helices predicted for STM_MW07901 by TMHMM2.0 at aa 16-38, 48-70 and 91-113 568708003525 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 568708003526 L-aspartate oxidase; Provisional; Region: PRK06175 568708003527 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 568708003530 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 568708003531 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 568708003532 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 568708003533 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 568708003534 TPP-binding site [chemical binding]; other site 568708003535 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 568708003536 dimer interface [polypeptide binding]; other site 568708003537 PYR/PP interface [polypeptide binding]; other site 568708003538 TPP binding site [chemical binding]; other site 568708003541 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 568708003542 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568708003543 E3 interaction surface; other site 568708003544 lipoyl attachment site [posttranslational modification]; other site 568708003545 e3 binding domain; Region: E3_binding; pfam02817 568708003546 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 568708003550 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 568708003551 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 568708003552 CoA-ligase; Region: Ligase_CoA; pfam00549 568708003555 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 568708003556 CoA binding domain; Region: CoA_binding; smart00881 568708003557 CoA-ligase; Region: Ligase_CoA; pfam00549 568708003560 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 568708003561 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 568708003563 9 probable transmembrane helices predicted for STM_MW07971 by TMHMM2.0 at aa 20-42, 54-76, 96-118, 130-152, 184-206, 219-238, 387-409, 421-443 and 472-494 568708003564 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 568708003565 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 568708003566 8 probable transmembrane helices predicted for STM_MW07981 by TMHMM2.0 at aa 7-24, 77-99, 122-144, 159-181, 202-224, 262-281, 293-315 and 335-357 568708003568 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 568708003569 Signal peptide predicted for STM_MW07991 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.695 between residues 23 and 24 568708003571 1 probable transmembrane helix predicted for STM_MW07991 by TMHMM2.0 at aa 2-24 568708003572 hypothetical protein; Provisional; Region: PRK10588 568708003574 3 probable transmembrane helices predicted for STM_MW08001 by TMHMM2.0 at aa 13-32, 42-64 and 69-91 568708003575 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 568708003576 active site 568708003578 colicin uptake protein TolQ; Provisional; Region: PRK10801 568708003579 3 probable transmembrane helices predicted for STM_MW08021 by TMHMM2.0 at aa 15-37, 133-155 and 170-192 568708003581 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 568708003582 colicin uptake protein TolR; Provisional; Region: PRK11024 568708003584 1 probable transmembrane helix predicted for STM_MW08031 by TMHMM2.0 at aa 17-39 568708003585 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 568708003586 TolA C-terminal; Region: TolA; pfam06519 568708003587 1 probable transmembrane helix predicted for STM_MW08041 by TMHMM2.0 at aa 13-35 568708003589 translocation protein TolB; Provisional; Region: tolB; PRK03629 568708003590 TolB amino-terminal domain; Region: TolB_N; pfam04052 568708003591 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 568708003592 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 568708003593 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 568708003594 Signal peptide predicted for STM_MW08051 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.993 between residues 21 and 22 568708003597 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 568708003598 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568708003599 ligand binding site [chemical binding]; other site 568708003600 Signal peptide predicted for STM_MW08061 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.451 between residues 26 and 27 568708003602 tol-pal system protein YbgF; Provisional; Region: PRK10803 568708003603 Tetratricopeptide repeat; Region: TPR_6; pfam13174 568708003604 Tetratricopeptide repeat; Region: TPR_6; pfam13174 568708003605 Signal peptide predicted for STM_MW08071 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 26 and 27 568708003606 quinolinate synthetase; Provisional; Region: PRK09375 568708003608 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 568708003609 6 probable transmembrane helices predicted for STM_MW08091 by TMHMM2.0 at aa 20-42, 49-68, 72-89, 110-127, 158-177 and 184-206 568708003611 zinc transporter ZitB; Provisional; Region: PRK03557 568708003613 5 probable transmembrane helices predicted for STM_MW08101 by TMHMM2.0 at aa 21-43, 53-71, 84-106, 121-143 and 164-183 568708003614 YbgS-like protein; Region: YbgS; pfam13985 568708003615 Signal peptide predicted for STM_MW08111 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25 568708003616 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 568708003617 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 568708003619 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 568708003621 fumarate hydratase; Provisional; Region: PRK06246 568708003623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708003624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708003625 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568708003626 dimerization interface [polypeptide binding]; other site 568708003629 cell density-dependent motility repressor; Provisional; Region: PRK10082 568708003630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708003631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568708003632 dimerization interface [polypeptide binding]; other site 568708003635 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 568708003636 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 568708003637 transmembrane helices; other site 568708003638 12 probable transmembrane helices predicted for STM_MW08171 by TMHMM2.0 at aa 2-19, 23-42, 54-76, 91-124, 137-159, 174-196, 221-240, 250-267, 272-294, 304-326, 360-379 and 399-421 568708003640 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 568708003642 1 probable transmembrane helix predicted for STM_MW08181 by TMHMM2.0 at aa 10-32 568708003643 oxaloacetate decarboxylase; Provisional; Region: PRK14040 568708003644 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 568708003645 active site 568708003646 catalytic residues [active] 568708003647 metal binding site [ion binding]; metal-binding site 568708003648 homodimer binding site [polypeptide binding]; other site 568708003649 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568708003650 carboxyltransferase (CT) interaction site; other site 568708003651 biotinylation site [posttranslational modification]; other site 568708003655 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 568708003656 9 probable transmembrane helices predicted for STM_MW08201 by TMHMM2.0 at aa 13-35, 42-64, 125-147, 160-182, 214-236, 266-288, 308-327, 339-361 and 409-431 568708003658 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 568708003660 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 568708003661 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568708003662 dimer interface [polypeptide binding]; other site 568708003663 putative PBP binding regions; other site 568708003664 ABC-ATPase subunit interface; other site 568708003665 9 probable transmembrane helices predicted for STM_MW08221 by TMHMM2.0 at aa 30-49, 81-103, 115-137, 142-161, 174-196, 216-236, 268-290, 305-324 and 331-353 568708003667 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 568708003668 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 568708003669 Walker A/P-loop; other site 568708003670 ATP binding site [chemical binding]; other site 568708003671 Q-loop/lid; other site 568708003672 ABC transporter signature motif; other site 568708003673 Walker B; other site 568708003674 D-loop; other site 568708003675 H-loop/switch region; other site 568708003677 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568708003678 catalytic core [active] 568708003679 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568708003681 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 568708003682 active site 568708003683 catalytic residues [active] 568708003685 galactokinase; Provisional; Region: PRK05101 568708003686 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 568708003687 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568708003688 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 568708003692 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 568708003693 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 568708003694 dimer interface [polypeptide binding]; other site 568708003695 active site 568708003698 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 568708003699 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 568708003700 NAD binding site [chemical binding]; other site 568708003701 homodimer interface [polypeptide binding]; other site 568708003702 active site 568708003703 substrate binding site [chemical binding]; other site 568708003705 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 568708003706 1 probable transmembrane helix predicted for STM_MW08291 by TMHMM2.0 at aa 271-293 568708003708 Signal peptide predicted for STM_MW08291 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 24 and 25 568708003709 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 568708003710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708003711 Walker A/P-loop; other site 568708003712 ATP binding site [chemical binding]; other site 568708003713 Q-loop/lid; other site 568708003714 ABC transporter signature motif; other site 568708003715 Walker B; other site 568708003716 D-loop; other site 568708003717 H-loop/switch region; other site 568708003718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708003719 Walker A/P-loop; other site 568708003720 ATP binding site [chemical binding]; other site 568708003721 Q-loop/lid; other site 568708003722 ABC transporter signature motif; other site 568708003723 Walker B; other site 568708003724 D-loop; other site 568708003725 H-loop/switch region; other site 568708003727 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 568708003728 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 568708003729 molybdenum-pterin binding domain; Region: Mop; TIGR00638 568708003730 TOBE domain; Region: TOBE; pfam03459 568708003733 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 568708003735 1 probable transmembrane helix predicted for STM_MW08321 by TMHMM2.0 at aa 42-64 568708003736 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 568708003737 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568708003738 substrate binding pocket [chemical binding]; other site 568708003739 membrane-bound complex binding site; other site 568708003740 hinge residues; other site 568708003741 Signal peptide predicted for STM_MW08331 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25 568708003743 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 568708003744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708003745 dimer interface [polypeptide binding]; other site 568708003746 conserved gate region; other site 568708003747 putative PBP binding loops; other site 568708003748 ABC-ATPase subunit interface; other site 568708003749 5 probable transmembrane helices predicted for STM_MW08341 by TMHMM2.0 at aa 15-37, 49-71, 86-108, 136-158 and 197-219 568708003751 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 568708003752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708003753 Walker A/P-loop; other site 568708003754 ATP binding site [chemical binding]; other site 568708003755 Q-loop/lid; other site 568708003756 ABC transporter signature motif; other site 568708003757 Walker B; other site 568708003758 D-loop; other site 568708003759 H-loop/switch region; other site 568708003760 molybdenum-pterin binding domain; Region: Mop; TIGR00638 568708003763 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 568708003764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708003765 active site 568708003766 motif I; other site 568708003767 motif II; other site 568708003768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708003770 6-phosphogluconolactonase; Provisional; Region: PRK11028 568708003772 acyl-CoA thioesterase; Provisional; Region: PRK10531 568708003773 putative pectinesterase; Region: PLN02432; cl01911 568708003775 Signal peptide predicted for STM_MW08381 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.861 between residues 23 and 24 568708003776 imidazolonepropionase; Validated; Region: PRK09356 568708003777 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 568708003778 active site 568708003780 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 568708003781 putative active site [active] 568708003782 putative metal binding site [ion binding]; other site 568708003784 histidine utilization repressor; Provisional; Region: PRK14999 568708003785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708003786 DNA-binding site [nucleotide binding]; DNA binding site 568708003787 UTRA domain; Region: UTRA; pfam07702 568708003790 urocanate hydratase; Provisional; Region: PRK05414 568708003792 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 568708003793 active sites [active] 568708003794 tetramer interface [polypeptide binding]; other site 568708003796 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 568708003797 substrate binding site [chemical binding]; other site 568708003799 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 568708003800 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568708003801 inhibitor-cofactor binding pocket; inhibition site 568708003802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708003803 catalytic residue [active] 568708003805 biotin synthase; Provisional; Region: PRK15108 568708003806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708003807 FeS/SAM binding site; other site 568708003808 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 568708003811 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 568708003812 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 568708003813 substrate-cofactor binding pocket; other site 568708003814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708003815 catalytic residue [active] 568708003817 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 568708003818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708003819 S-adenosylmethionine binding site [chemical binding]; other site 568708003821 AAA domain; Region: AAA_26; pfam13500 568708003822 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 568708003824 excinuclease ABC subunit B; Provisional; Region: PRK05298 568708003825 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568708003826 ATP binding site [chemical binding]; other site 568708003827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708003828 nucleotide binding region [chemical binding]; other site 568708003829 ATP-binding site [chemical binding]; other site 568708003830 Ultra-violet resistance protein B; Region: UvrB; pfam12344 568708003831 UvrB/uvrC motif; Region: UVR; pfam02151 568708003835 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 568708003836 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 568708003837 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 568708003838 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 568708003839 Leucine-rich repeats; other site 568708003840 Substrate binding site [chemical binding]; other site 568708003842 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 568708003843 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 568708003844 putative substrate binding pocket [chemical binding]; other site 568708003845 dimer interface [polypeptide binding]; other site 568708003846 phosphate binding site [ion binding]; other site 568708003848 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 568708003849 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708003850 FeS/SAM binding site; other site 568708003851 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 568708003854 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 568708003855 MPT binding site; other site 568708003856 trimer interface [polypeptide binding]; other site 568708003858 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 568708003859 trimer interface [polypeptide binding]; other site 568708003860 dimer interface [polypeptide binding]; other site 568708003861 putative active site [active] 568708003863 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 568708003864 MoaE interaction surface [polypeptide binding]; other site 568708003865 MoeB interaction surface [polypeptide binding]; other site 568708003866 thiocarboxylated glycine; other site 568708003868 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 568708003869 MoaE homodimer interface [polypeptide binding]; other site 568708003870 MoaD interaction [polypeptide binding]; other site 568708003871 active site residues [active] 568708003873 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 568708003874 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 568708003875 7 probable transmembrane helices predicted for STM_MW08591 by TMHMM2.0 at aa 20-42, 57-76, 88-107, 112-131, 138-160, 165-184 and 209-231 568708003877 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 568708003878 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 568708003879 7 probable transmembrane helices predicted for STM_MW08601 by TMHMM2.0 at aa 21-43, 48-70, 77-99, 103-125, 132-154, 159-181 and 202-224 568708003880 4 probable transmembrane helices predicted for STM_MW08611 by TMHMM2.0 at aa 64-83, 93-115, 120-142 and 157-179 568708003881 4 probable transmembrane helices predicted for STM_MW08621 by TMHMM2.0 at aa 44-66, 81-103, 115-137 and 147-169 568708003882 Predicted integral membrane protein [Function unknown]; Region: COG0392 568708003883 8 probable transmembrane helices predicted for STM_MW08631 by TMHMM2.0 at aa 13-30, 50-72, 85-107, 127-149, 162-184, 204-226, 233-255 and 281-303 568708003885 Signal peptide predicted for STM_MW08631 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.923 between residues 31 and 32 568708003886 cardiolipin synthase 2; Provisional; Region: PRK11263 568708003887 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 568708003888 putative active site [active] 568708003889 catalytic site [active] 568708003890 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 568708003891 putative active site [active] 568708003892 catalytic site [active] 568708003894 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 568708003895 putative catalytic site [active] 568708003896 putative metal binding site [ion binding]; other site 568708003897 putative phosphate binding site [ion binding]; other site 568708003899 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 568708003901 4 probable transmembrane helices predicted for STM_MW08661 by TMHMM2.0 at aa 13-32, 36-58, 79-96 and 100-119 568708003902 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568708003903 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 568708003904 6 probable transmembrane helices predicted for STM_MW08671 by TMHMM2.0 at aa 24-46, 173-195, 223-245, 255-277, 284-303 and 338-360 568708003906 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568708003907 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 568708003908 6 probable transmembrane helices predicted for STM_MW08681 by TMHMM2.0 at aa 26-48, 181-203, 230-252, 262-284, 291-313 and 347-369 568708003910 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568708003911 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568708003912 Walker A/P-loop; other site 568708003913 ATP binding site [chemical binding]; other site 568708003914 Q-loop/lid; other site 568708003915 ABC transporter signature motif; other site 568708003916 Walker B; other site 568708003917 D-loop; other site 568708003918 H-loop/switch region; other site 568708003919 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 568708003920 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568708003921 Walker A/P-loop; other site 568708003922 ATP binding site [chemical binding]; other site 568708003923 Q-loop/lid; other site 568708003924 ABC transporter signature motif; other site 568708003925 Walker B; other site 568708003926 D-loop; other site 568708003927 H-loop/switch region; other site 568708003929 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 568708003930 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568708003931 HlyD family secretion protein; Region: HlyD_3; pfam13437 568708003933 1 probable transmembrane helix predicted for STM_MW08701 by TMHMM2.0 at aa 5-27 568708003934 Signal peptide predicted for STM_MW08701 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.948 between residues 19 and 20 568708003935 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 568708003936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708003937 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 568708003940 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 568708003941 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568708003942 ATP binding site [chemical binding]; other site 568708003943 Mg++ binding site [ion binding]; other site 568708003944 motif III; other site 568708003945 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708003946 nucleotide binding region [chemical binding]; other site 568708003947 ATP-binding site [chemical binding]; other site 568708003950 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 568708003951 DEAD_2; Region: DEAD_2; pfam06733 568708003952 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 568708003955 glycosyl transferase family protein; Provisional; Region: PRK08136 568708003956 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 568708003958 hypothetical protein; Provisional; Region: PRK10259 568708003960 Signal peptide predicted for STM_MW08751 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 22 and 23 568708003961 hypothetical protein; Provisional; Region: PRK11019 568708003963 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 568708003964 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 568708003966 putative mechanosensitive channel protein; Provisional; Region: PRK11465 568708003967 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568708003968 11 probable transmembrane helices predicted for STM_MW08781 by TMHMM2.0 at aa 5-27, 136-158, 179-201, 216-238, 267-284, 294-313, 333-355, 370-392, 427-449, 464-486 and 507-529 568708003970 Signal peptide predicted for STM_MW08781 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.912 between residues 18 and 19 568708003971 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 568708003972 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568708003973 Walker A/P-loop; other site 568708003974 ATP binding site [chemical binding]; other site 568708003975 Q-loop/lid; other site 568708003976 ABC transporter signature motif; other site 568708003977 Walker B; other site 568708003978 D-loop; other site 568708003979 H-loop/switch region; other site 568708003981 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568708003982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708003983 dimer interface [polypeptide binding]; other site 568708003984 conserved gate region; other site 568708003985 putative PBP binding loops; other site 568708003986 ABC-ATPase subunit interface; other site 568708003987 5 probable transmembrane helices predicted for STM_MW08801 by TMHMM2.0 at aa 20-42, 55-77, 92-114, 155-177 and 187-209 568708003989 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 568708003990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568708003991 substrate binding pocket [chemical binding]; other site 568708003992 membrane-bound complex binding site; other site 568708003993 hinge residues; other site 568708003995 Signal peptide predicted for STM_MW08811 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708003996 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 568708003997 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 568708003998 dimerization interface [polypeptide binding]; other site 568708003999 DPS ferroxidase diiron center [ion binding]; other site 568708004000 ion pore; other site 568708004002 threonine and homoserine efflux system; Provisional; Region: PRK10532 568708004003 EamA-like transporter family; Region: EamA; pfam00892 568708004004 10 probable transmembrane helices predicted for STM_MW08831 by TMHMM2.0 at aa 7-24, 37-59, 72-89, 93-115, 122-139, 143-165, 177-199, 203-225, 238-257 and 261-283 568708004006 Signal peptide predicted for STM_MW08831 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.891 between residues 31 and 32 568708004007 outer membrane protein X; Provisional; Region: ompX; PRK09408 568708004008 Signal peptide predicted for STM_MW08841 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 23 and 24 568708004010 1 probable transmembrane helix predicted for STM_MW08841 by TMHMM2.0 at aa 7-29 568708004011 pfam_scan;Pfam:PF00884; E()=1.9E-51;score=174.3;query 219-488;description=Sulfatase; tmhmm; query 1-526 568708004013 manganese transport regulator MntR; Provisional; Region: PRK11050 568708004014 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 568708004015 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 568708004018 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 568708004019 transmembrane helices; other site 568708004020 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 568708004021 Signal peptide predicted for STM_MW08871 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.971 between residues 35 and 36 568708004022 9 probable transmembrane helices predicted for STM_MW08871 by TMHMM2.0 at aa 13-32, 42-64, 84-106, 165-187, 223-242, 246-268, 281-303, 313-335 and 347-369 568708004024 L,D-transpeptidase; Provisional; Region: PRK10260 568708004025 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568708004027 1 probable transmembrane helix predicted for STM_MW08881 by TMHMM2.0 at aa 7-29 568708004028 Signal peptide predicted for STM_MW08881 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 24 and 25 568708004029 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 568708004030 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568708004031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708004032 Walker A/P-loop; other site 568708004033 ATP binding site [chemical binding]; other site 568708004034 ABC transporter signature motif; other site 568708004035 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568708004036 Walker B; other site 568708004037 ABC transporter; Region: ABC_tran_2; pfam12848 568708004038 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568708004040 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 568708004041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708004043 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 568708004045 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 568708004046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708004047 active site 568708004048 motif I; other site 568708004049 motif II; other site 568708004050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708004052 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 568708004053 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 568708004054 dimer interface [polypeptide binding]; other site 568708004055 active site 568708004056 glycine loop; other site 568708004059 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 568708004060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708004061 FeS/SAM binding site; other site 568708004063 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 568708004064 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 568708004065 ATP binding site [chemical binding]; other site 568708004066 substrate interface [chemical binding]; other site 568708004069 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 568708004070 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 568708004071 dimer interface [polypeptide binding]; other site 568708004072 putative functional site; other site 568708004073 putative MPT binding site; other site 568708004077 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 568708004078 catalytic nucleophile [active] 568708004080 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 568708004081 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568708004082 Walker A/P-loop; other site 568708004083 ATP binding site [chemical binding]; other site 568708004084 Q-loop/lid; other site 568708004085 ABC transporter signature motif; other site 568708004086 Walker B; other site 568708004087 D-loop; other site 568708004088 H-loop/switch region; other site 568708004089 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568708004090 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568708004091 Walker A/P-loop; other site 568708004092 ATP binding site [chemical binding]; other site 568708004093 Q-loop/lid; other site 568708004094 ABC transporter signature motif; other site 568708004095 Walker B; other site 568708004096 D-loop; other site 568708004097 H-loop/switch region; other site 568708004098 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568708004101 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 568708004102 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 568708004103 Signal peptide predicted for STM_MW09001 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.982 between residues 26 and 27 568708004105 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 568708004106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708004107 dimer interface [polypeptide binding]; other site 568708004108 conserved gate region; other site 568708004109 putative PBP binding loops; other site 568708004110 ABC-ATPase subunit interface; other site 568708004111 Signal peptide predicted for STM_MW09011 by SignalP 2.0 HMM (Signal peptide probability 0.619) with cleavage site probability 0.435 between residues 29 and 30 568708004112 6 probable transmembrane helices predicted for STM_MW09011 by TMHMM2.0 at aa 9-31, 101-123, 135-157, 172-189, 227-249 and 278-300 568708004114 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 568708004115 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568708004116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708004117 dimer interface [polypeptide binding]; other site 568708004118 conserved gate region; other site 568708004119 putative PBP binding loops; other site 568708004120 ABC-ATPase subunit interface; other site 568708004121 6 probable transmembrane helices predicted for STM_MW09021 by TMHMM2.0 at aa 39-61, 107-129, 136-158, 163-185, 209-231 and 266-288 568708004123 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 568708004124 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 568708004125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708004126 FeS/SAM binding site; other site 568708004129 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 568708004131 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 568708004133 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 568708004134 Ligand binding site [chemical binding]; other site 568708004135 Electron transfer flavoprotein domain; Region: ETF; pfam01012 568708004137 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 568708004138 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 568708004139 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 568708004142 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568708004143 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568708004144 active site 568708004148 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 568708004149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568708004150 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 568708004151 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 568708004154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708004155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708004156 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 568708004157 putative dimerization interface [polypeptide binding]; other site 568708004160 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 568708004162 3 probable transmembrane helices predicted for STM_MW09111 by TMHMM2.0 at aa 7-29, 53-75 and 96-118 568708004163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 568708004164 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 568708004165 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 568708004166 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 568708004167 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 568708004170 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 568708004171 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 568708004172 putative C-terminal domain interface [polypeptide binding]; other site 568708004173 putative GSH binding site (G-site) [chemical binding]; other site 568708004174 putative dimer interface [polypeptide binding]; other site 568708004175 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 568708004176 putative N-terminal domain interface [polypeptide binding]; other site 568708004177 putative dimer interface [polypeptide binding]; other site 568708004178 putative substrate binding pocket (H-site) [chemical binding]; other site 568708004181 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 568708004182 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 568708004183 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 568708004184 Signal peptide predicted for STM_MW09141 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 27 and 28 568708004187 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 568708004188 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 568708004189 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708004192 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 568708004193 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 568708004194 active site 568708004195 4 probable transmembrane helices predicted for STM_MW09161 by TMHMM2.0 at aa 26-48, 60-82, 126-148 and 155-177 568708004197 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 568708004198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708004199 putative substrate translocation pore; other site 568708004200 12 probable transmembrane helices predicted for STM_MW09171 by TMHMM2.0 at aa 16-38, 53-72, 84-101, 111-130, 142-164, 169-188, 220-242, 257-279, 286-308, 313-335, 348-367 and 377-399 568708004202 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 568708004203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708004204 active site 568708004205 motif I; other site 568708004206 motif II; other site 568708004207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708004209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708004210 putative substrate translocation pore; other site 568708004211 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568708004212 12 probable transmembrane helices predicted for STM_MW09191 by TMHMM2.0 at aa 13-35, 50-72, 79-101, 105-124, 145-164, 168-190, 211-233, 253-275, 282-301, 305-327, 340-362 and 367-389 568708004214 Signal peptide predicted for STM_MW09191 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.955 between residues 29 and 30 568708004215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 568708004216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708004217 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 568708004219 putative transporter; Provisional; Region: PRK04972 568708004220 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 568708004221 TrkA-C domain; Region: TrkA_C; pfam02080 568708004222 TrkA-C domain; Region: TrkA_C; pfam02080 568708004223 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 568708004224 9 probable transmembrane helices predicted for STM_MW09211 by TMHMM2.0 at aa 13-35, 64-86, 93-115, 159-181, 383-402, 406-428, 449-471, 476-498 and 535-557 568708004227 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 568708004228 Signal peptide predicted for STM_MW09221 by SignalP 2.0 HMM (Signal peptide probability 0.883) with cleavage site probability 0.349 between residues 36 and 37 568708004230 4 probable transmembrane helices predicted for STM_MW09221 by TMHMM2.0 at aa 7-29, 34-56, 61-83 and 93-115 568708004231 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 568708004232 GSH binding site [chemical binding]; other site 568708004233 catalytic residues [active] 568708004235 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 568708004237 2 probable transmembrane helices predicted for STM_MW09241 by TMHMM2.0 at aa 13-35 and 45-67 568708004238 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 568708004239 dimer interface [polypeptide binding]; other site 568708004240 FMN binding site [chemical binding]; other site 568708004241 NADPH bind site [chemical binding]; other site 568708004243 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 568708004244 RimK-like ATP-grasp domain; Region: RimK; pfam08443 568708004246 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 568708004248 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 568708004249 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568708004250 Signal peptide predicted for STM_MW09281 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.946 between residues 26 and 27 568708004252 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 568708004253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708004254 Walker A/P-loop; other site 568708004255 ATP binding site [chemical binding]; other site 568708004256 Q-loop/lid; other site 568708004257 ABC transporter signature motif; other site 568708004258 Walker B; other site 568708004259 D-loop; other site 568708004260 H-loop/switch region; other site 568708004261 TOBE domain; Region: TOBE_2; pfam08402 568708004264 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 568708004265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708004266 dimer interface [polypeptide binding]; other site 568708004267 conserved gate region; other site 568708004268 putative PBP binding loops; other site 568708004269 ABC-ATPase subunit interface; other site 568708004270 6 probable transmembrane helices predicted for STM_MW09301 by TMHMM2.0 at aa 31-52, 100-122, 135-157, 185-207, 228-250 and 284-306 568708004272 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568708004273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708004274 dimer interface [polypeptide binding]; other site 568708004275 conserved gate region; other site 568708004276 putative PBP binding loops; other site 568708004277 ABC-ATPase subunit interface; other site 568708004278 6 probable transmembrane helices predicted for STM_MW09311 by TMHMM2.0 at aa 13-35, 69-91, 104-126, 141-163, 184-206 and 242-264 568708004280 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 568708004281 4 probable transmembrane helices predicted for STM_MW09321 by TMHMM2.0 at aa 13-35, 60-82, 89-111 and 126-148 568708004283 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 568708004284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708004285 S-adenosylmethionine binding site [chemical binding]; other site 568708004287 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 568708004288 11 probable transmembrane helices predicted for STM_MW09341 by TMHMM2.0 at aa 15-37, 44-66, 103-125, 132-154, 159-181, 233-255, 270-292, 330-352, 356-378, 385-407 and 422-444 568708004290 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 568708004291 active site 568708004292 P-loop; other site 568708004293 phosphorylation site [posttranslational modification] 568708004295 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 568708004296 Sulfatase; Region: Sulfatase; cl17466 568708004298 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 568708004299 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568708004300 substrate binding pocket [chemical binding]; other site 568708004301 membrane-bound complex binding site; other site 568708004302 hinge residues; other site 568708004304 Signal peptide predicted for STM_MW09371 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 19 and 20 568708004305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708004306 dimer interface [polypeptide binding]; other site 568708004307 conserved gate region; other site 568708004308 putative PBP binding loops; other site 568708004309 ABC-ATPase subunit interface; other site 568708004310 5 probable transmembrane helices predicted for STM_MW09381 by TMHMM2.0 at aa 15-37, 46-68, 83-105, 155-174 and 189-211 568708004312 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568708004313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708004314 dimer interface [polypeptide binding]; other site 568708004315 conserved gate region; other site 568708004316 putative PBP binding loops; other site 568708004317 ABC-ATPase subunit interface; other site 568708004318 4 probable transmembrane helices predicted for STM_MW09391 by TMHMM2.0 at aa 10-32, 45-67, 101-118 and 201-223 568708004320 Signal peptide predicted for STM_MW09391 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.719 between residues 29 and 30 568708004321 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 568708004322 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568708004323 substrate binding pocket [chemical binding]; other site 568708004324 membrane-bound complex binding site; other site 568708004325 hinge residues; other site 568708004327 Signal peptide predicted for STM_MW09401 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 19 and 20 568708004328 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 568708004329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708004330 Walker A/P-loop; other site 568708004331 ATP binding site [chemical binding]; other site 568708004332 Q-loop/lid; other site 568708004333 ABC transporter signature motif; other site 568708004334 Walker B; other site 568708004335 D-loop; other site 568708004336 H-loop/switch region; other site 568708004338 putative lipoprotein; Provisional; Region: PRK10533 568708004339 Signal peptide predicted for STM_MW09421 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.788 between residues 27 and 28 568708004340 hypothetical protein; Provisional; Region: PRK02877 568708004342 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 568708004343 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 568708004344 amidase catalytic site [active] 568708004345 Zn binding residues [ion binding]; other site 568708004346 substrate binding site [chemical binding]; other site 568708004347 Signal peptide predicted for STM_MW09441 by SignalP 2.0 HMM (Signal peptide probability 0.928) with cleavage site probability 0.563 between residues 20 and 21 568708004349 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568708004350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568708004351 NAD(P) binding site [chemical binding]; other site 568708004352 active site 568708004354 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 568708004355 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 568708004356 putative NAD(P) binding site [chemical binding]; other site 568708004357 putative active site [active] 568708004358 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 568708004361 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 568708004362 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 568708004363 tetramer interface [polypeptide binding]; other site 568708004364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708004365 catalytic residue [active] 568708004367 pyruvate dehydrogenase; Provisional; Region: PRK09124 568708004368 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 568708004369 PYR/PP interface [polypeptide binding]; other site 568708004370 dimer interface [polypeptide binding]; other site 568708004371 tetramer interface [polypeptide binding]; other site 568708004372 TPP binding site [chemical binding]; other site 568708004373 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568708004374 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 568708004375 TPP-binding site [chemical binding]; other site 568708004379 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 568708004380 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 568708004381 FAD binding pocket [chemical binding]; other site 568708004382 FAD binding motif [chemical binding]; other site 568708004383 phosphate binding motif [ion binding]; other site 568708004384 beta-alpha-beta structure motif; other site 568708004385 NAD binding pocket [chemical binding]; other site 568708004386 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568708004387 catalytic loop [active] 568708004388 iron binding site [ion binding]; other site 568708004392 hybrid cluster protein; Provisional; Region: PRK05290 568708004393 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 568708004394 ACS interaction site; other site 568708004395 CODH interaction site; other site 568708004396 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 568708004397 hybrid metal cluster; other site 568708004399 Predicted membrane protein [Function unknown]; Region: COG2431 568708004400 6 probable transmembrane helices predicted for STM_MW09511 by TMHMM2.0 at aa 25-47, 75-97, 102-119, 131-153, 168-190 and 239-261 568708004402 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 568708004403 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 568708004404 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 568708004405 putative active site [active] 568708004406 putative metal-binding site [ion binding]; other site 568708004408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 568708004410 macrolide transporter subunit MacA; Provisional; Region: PRK11578 568708004411 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568708004412 HlyD family secretion protein; Region: HlyD_3; pfam13437 568708004413 Signal peptide predicted for STM_MW09541 by SignalP 2.0 HMM (Signal peptide probability 0.838) with cleavage site probability 0.809 between residues 25 and 26 568708004414 1 probable transmembrane helix predicted for STM_MW09541 by TMHMM2.0 at aa 13-30 568708004416 pfam_scan;Pfam:PF00005; E()=1.8E-44;score=151.8;query 34-202;description=ABC_tran; pfam_scan;Pfam:PF02687; E()=2.0E-28;score=98.5;query469-640;description=FtsX; tmhmm; query 1-648 568708004419 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568708004420 DNA-binding site [nucleotide binding]; DNA binding site 568708004421 RNA-binding motif; other site 568708004423 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 568708004425 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 568708004426 Clp amino terminal domain; Region: Clp_N; pfam02861 568708004427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708004428 Walker A motif; other site 568708004429 ATP binding site [chemical binding]; other site 568708004430 Walker B motif; other site 568708004431 arginine finger; other site 568708004432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708004433 Walker A motif; other site 568708004434 ATP binding site [chemical binding]; other site 568708004435 Walker B motif; other site 568708004436 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 568708004441 Transposase IS200 like; Region: Y1_Tnp; pfam01797 568708004443 Integrase core domain; Region: rve; pfam00665 568708004444 Integrase core domain; Region: rve_3; pfam13683 568708004446 Helix-turn-helix domain; Region: HTH_28; pfam13518 568708004447 Isochorismatase family; Region: Isochorismatase; pfam00857 568708004448 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 568708004449 catalytic triad [active] 568708004450 dimer interface [polypeptide binding]; other site 568708004451 conserved cis-peptide bond; other site 568708004453 Pirin-related protein [General function prediction only]; Region: COG1741 568708004454 Pirin; Region: Pirin; pfam02678 568708004455 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 568708004458 LysR family transcriptional regulator; Provisional; Region: PRK14997 568708004459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708004460 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 568708004461 putative effector binding pocket; other site 568708004462 putative dimerization interface [polypeptide binding]; other site 568708004465 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 568708004466 rRNA binding site [nucleotide binding]; other site 568708004467 predicted 30S ribosome binding site; other site 568708004469 1 probable transmembrane helix predicted for STM_MW09661 by TMHMM2.0 at aa 29-51 568708004470 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 568708004472 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 568708004473 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568708004474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708004475 Walker A/P-loop; other site 568708004476 ATP binding site [chemical binding]; other site 568708004477 Q-loop/lid; other site 568708004478 ABC transporter signature motif; other site 568708004479 Walker B; other site 568708004480 D-loop; other site 568708004481 H-loop/switch region; other site 568708004483 6 probable transmembrane helices predicted for STM_MW09681 by TMHMM2.0 at aa 20-42, 47-69, 133-155, 160-182, 246-268 and 278-300 568708004485 Signal peptide predicted for STM_MW09681 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.650 between residues 49 and 50 568708004486 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 568708004487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568708004488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708004489 Walker A/P-loop; other site 568708004490 ATP binding site [chemical binding]; other site 568708004491 Q-loop/lid; other site 568708004492 ABC transporter signature motif; other site 568708004493 Walker B; other site 568708004494 D-loop; other site 568708004495 H-loop/switch region; other site 568708004497 6 probable transmembrane helices predicted for STM_MW09691 by TMHMM2.0 at aa 24-46, 61-80, 137-159, 163-185, 245-267 and 282-304 568708004499 Signal peptide predicted for STM_MW09691 by SignalP 2.0 HMM (Signal peptide probability 0.618) with cleavage site probability 0.535 between residues 42 and 43 568708004500 thioredoxin reductase; Provisional; Region: PRK10262 568708004501 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568708004502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568708004505 Signal peptide predicted for STM_MW09701 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.968 between residues 25 and 26 568708004506 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 568708004507 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568708004508 putative DNA binding site [nucleotide binding]; other site 568708004509 putative Zn2+ binding site [ion binding]; other site 568708004510 AsnC family; Region: AsnC_trans_reg; pfam01037 568708004512 DNA translocase FtsK; Provisional; Region: PRK10263 568708004513 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 568708004514 DNA translocase FtsK; Provisional; Region: PRK10263 568708004515 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 568708004516 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 568708004517 5 probable transmembrane helices predicted for STM_MW09721 by TMHMM2.0 at aa 41-63, 94-116, 129-151, 156-177 and 184-206 568708004520 periplasmic chaperone LolA; Region: lolA; TIGR00547 568708004521 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 568708004522 Signal peptide predicted for STM_MW09731 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 22 and 23 568708004524 recombination factor protein RarA; Reviewed; Region: PRK13342 568708004525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708004526 Walker A motif; other site 568708004527 ATP binding site [chemical binding]; other site 568708004528 Walker B motif; other site 568708004529 arginine finger; other site 568708004530 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 568708004532 seryl-tRNA synthetase; Provisional; Region: PRK05431 568708004533 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 568708004534 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 568708004535 dimer interface [polypeptide binding]; other site 568708004536 active site 568708004537 motif 1; other site 568708004538 motif 2; other site 568708004539 motif 3; other site 568708004542 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 568708004543 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 568708004544 putative [Fe4-S4] binding site [ion binding]; other site 568708004545 putative molybdopterin cofactor binding site [chemical binding]; other site 568708004546 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 568708004547 putative molybdopterin cofactor binding site; other site 568708004548 Signal peptide predicted for STM_MW09761 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.950 between residues 45 and 46 568708004552 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 568708004553 4Fe-4S binding domain; Region: Fer4; pfam00037 568708004555 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 568708004557 8 probable transmembrane helices predicted for STM_MW09781 by TMHMM2.0 at aa 10-32, 44-66, 88-107, 114-134, 149-171, 178-200, 227-246 and 253-275 568708004558 putative MFS family transporter protein; Provisional; Region: PRK03633 568708004559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708004560 putative substrate translocation pore; other site 568708004561 Signal peptide predicted for STM_MW09791 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.629 between residues 23 and 24 568708004562 12 probable transmembrane helices predicted for STM_MW09791 by TMHMM2.0 at aa 7-29, 44-66, 73-95, 100-119, 131-150, 160-182, 204-226, 231-253, 265-284, 289-311, 320-342 and 352-369 568708004564 inner membrane transporter YjeM; Provisional; Region: PRK15238 568708004565 11 probable transmembrane helices predicted for STM_MW09801 by TMHMM2.0 at aa 10-29, 36-58, 127-146, 158-180, 195-217, 238-260, 287-309, 340-362, 377-399, 412-434 and 444-466 568708004567 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 568708004568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708004569 FeS/SAM binding site; other site 568708004571 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 568708004573 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 568708004574 Pyruvate formate lyase 1; Region: PFL1; cd01678 568708004575 coenzyme A binding site [chemical binding]; other site 568708004576 active site 568708004577 catalytic residues [active] 568708004578 glycine loop; other site 568708004581 formate transporter; Provisional; Region: PRK10805 568708004582 6 probable transmembrane helices predicted for STM_MW09851 by TMHMM2.0 at aa 35-57, 77-99, 119-141, 161-183, 195-217 and 256-278 568708004584 uncharacterized domain; Region: TIGR00702 568708004585 YcaO-like family; Region: YcaO; pfam02624 568708004587 Predicted membrane protein [Function unknown]; Region: COG2323 568708004588 3 probable transmembrane helices predicted for STM_MW09871 by TMHMM2.0 at aa 15-37, 50-69 and 74-91 568708004590 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 568708004591 homodimer interface [polypeptide binding]; other site 568708004592 substrate-cofactor binding pocket; other site 568708004593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708004594 catalytic residue [active] 568708004596 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 568708004597 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 568708004598 hinge; other site 568708004599 active site 568708004601 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 568708004602 Signal peptide predicted for STM_MW09901 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.678 between residues 18 and 19 568708004604 cytidylate kinase; Provisional; Region: cmk; PRK00023 568708004605 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 568708004606 CMP-binding site; other site 568708004607 The sites determining sugar specificity; other site 568708004609 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 568708004610 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 568708004611 RNA binding site [nucleotide binding]; other site 568708004612 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 568708004613 RNA binding site [nucleotide binding]; other site 568708004614 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 568708004615 RNA binding site [nucleotide binding]; other site 568708004616 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 568708004617 RNA binding site [nucleotide binding]; other site 568708004618 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 568708004619 RNA binding site [nucleotide binding]; other site 568708004621 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568708004622 IHF dimer interface [polypeptide binding]; other site 568708004623 IHF - DNA interface [nucleotide binding]; other site 568708004625 ComEC family competence protein; Provisional; Region: PRK11539 568708004626 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 568708004627 Competence protein; Region: Competence; pfam03772 568708004628 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 568708004629 11 probable transmembrane helices predicted for STM_MW09941 by TMHMM2.0 at aa 5-22, 26-43, 50-69, 224-246, 259-281, 301-323, 328-346, 361-383, 390-412, 427-449 and 469-491 568708004632 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 568708004633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568708004634 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 568708004635 Walker A/P-loop; other site 568708004636 ATP binding site [chemical binding]; other site 568708004637 Q-loop/lid; other site 568708004638 ABC transporter signature motif; other site 568708004639 Walker B; other site 568708004640 D-loop; other site 568708004641 H-loop/switch region; other site 568708004642 Signal peptide predicted for STM_MW09951 by SignalP 2.0 HMM (Signal peptide probability 0.612) with cleavage site probability 0.371 between residues 38 and 39 568708004643 5 probable transmembrane helices predicted for STM_MW09951 by TMHMM2.0 at aa 21-43, 63-94, 140-162, 167-186 and 245-267 568708004646 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 568708004647 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 568708004648 1 probable transmembrane helix predicted for STM_MW09961 by TMHMM2.0 at aa 12-34 568708004650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 568708004651 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 568708004653 hypothetical protein; Provisional; Region: PRK11827 568708004655 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 568708004656 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 568708004657 Ligand binding site; other site 568708004658 oligomer interface; other site 568708004660 hypothetical protein; Provisional; Region: PRK10593 568708004662 Uncharacterized conserved protein [Function unknown]; Region: COG1434 568708004663 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568708004664 putative active site [active] 568708004666 2 probable transmembrane helices predicted for STM_MW10011 by TMHMM2.0 at aa 10-32 and 41-58 568708004667 Signal peptide predicted for STM_MW10011 by SignalP 2.0 HMM (Signal peptide probability 0.897) with cleavage site probability 0.626 between residues 28 and 29 568708004668 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 568708004669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708004670 S-adenosylmethionine binding site [chemical binding]; other site 568708004672 condesin subunit F; Provisional; Region: PRK05260 568708004674 condesin subunit E; Provisional; Region: PRK05256 568708004676 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 568708004677 P-loop containing region of AAA domain; Region: AAA_29; cl17516 568708004678 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 568708004680 murein L,D-transpeptidase; Provisional; Region: PRK10594 568708004681 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568708004682 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568708004683 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568708004684 Signal peptide predicted for STM_MW10061 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 30 and 31 568708004687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 568708004688 Peptidase M15; Region: Peptidase_M15_3; cl01194 568708004689 Signal peptide predicted for STM_MW10071 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 30 and 31 568708004690 1 probable transmembrane helix predicted for STM_MW10071 by TMHMM2.0 at aa 12-34 568708004692 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 568708004694 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 568708004695 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568708004696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708004697 homodimer interface [polypeptide binding]; other site 568708004698 catalytic residue [active] 568708004700 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568708004701 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 568708004702 trimer interface [polypeptide binding]; other site 568708004703 eyelet of channel; other site 568708004705 Signal peptide predicted for STM_MW10101 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23 568708004706 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 568708004707 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 568708004708 putative dimer interface [polypeptide binding]; other site 568708004709 putative anticodon binding site; other site 568708004710 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 568708004711 homodimer interface [polypeptide binding]; other site 568708004712 motif 1; other site 568708004713 motif 2; other site 568708004714 active site 568708004715 motif 3; other site 568708004718 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568708004719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568708004720 putative DNA binding site [nucleotide binding]; other site 568708004721 putative Zn2+ binding site [ion binding]; other site 568708004722 AsnC family; Region: AsnC_trans_reg; pfam01037 568708004725 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 568708004726 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 568708004727 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568708004728 catalytic residue [active] 568708004730 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 568708004731 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 568708004732 11 probable transmembrane helices predicted for STM_MW10141 by TMHMM2.0 at aa 13-35, 76-98, 103-125, 152-174, 189-211, 218-240, 250-272, 314-336, 356-378, 399-418 and 422-439 568708004734 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 568708004735 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 568708004736 active site 568708004738 BTP2 568708004739 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 568708004740 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 568708004741 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 568708004742 Int/Topo IB signature motif; other site 568708004744 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 568708004746 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 568708004747 RecT family; Region: RecT; pfam03837 568708004749 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 568708004750 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 568708004752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708004753 non-specific DNA binding site [nucleotide binding]; other site 568708004754 salt bridge; other site 568708004755 sequence-specific DNA binding site [nucleotide binding]; other site 568708004757 Bacteriophage CII protein; Region: Phage_CII; pfam05269 568708004759 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 568708004760 primosomal protein DnaI; Provisional; Region: PRK02854 568708004762 putative replication protein; Provisional; Region: PRK12377 568708004763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708004764 Walker A motif; other site 568708004765 ATP binding site [chemical binding]; other site 568708004766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 568708004768 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 568708004770 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 568708004771 DinI-like family; Region: DinI; pfam06183 568708004773 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 568708004775 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 568708004777 Antitermination protein; Region: Antiterm; pfam03589 568708004778 Antitermination protein; Region: Antiterm; pfam03589 568708004781 Signal peptide predicted for STM_MW10371 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.767 between residues 31 and 32 568708004782 1 probable transmembrane helix predicted for STM_MW10371 by TMHMM2.0 at aa 9-31 568708004783 PipA protein; Region: PipA; pfam07108 568708004785 phage holin, lambda family; Region: holin_lambda; TIGR01594 568708004787 2 probable transmembrane helices predicted for STM_MW10392 by TMHMM2.0 at aa 20-37 and 50-72 568708004788 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 568708004789 catalytic residues [active] 568708004791 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 568708004792 Signal peptide predicted for STM_MW10401 by SignalP 2.0 HMM (Signal peptide probability 0.934) with cleavage site probability 0.701 between residues 24 and 25 568708004794 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 568708004796 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 568708004797 Domain of unknown function (DUF1859); Region: DUF1859; pfam08948 568708004799 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 568708004800 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 568708004802 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 568708004803 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 568708004804 oligomer interface [polypeptide binding]; other site 568708004805 active site residues [active] 568708004806 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 568708004809 Uncharacterized conserved protein [Function unknown]; Region: COG5471 568708004811 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 568708004812 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 568708004814 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 568708004816 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 568708004818 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 568708004820 Minor tail protein T; Region: Phage_tail_T; cl05636 568708004822 Phage-related minor tail protein [Function unknown]; Region: COG5281 568708004823 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 568708004824 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 568708004827 Phage-related protein [Function unknown]; Region: COG4718 568708004829 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 568708004830 Signal peptide predicted for STM_MW10541 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 22 and 23 568708004832 1 probable transmembrane helix predicted for STM_MW10541 by TMHMM2.0 at aa 4-25 568708004833 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 568708004834 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 568708004835 E-class dimer interface [polypeptide binding]; other site 568708004836 P-class dimer interface [polypeptide binding]; other site 568708004837 active site 568708004838 Cu2+ binding site [ion binding]; other site 568708004839 Zn2+ binding site [ion binding]; other site 568708004841 Signal peptide predicted for STM_MW10551 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 568708004842 Phage-related protein [Function unknown]; Region: gp18; COG4672 568708004844 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 568708004845 MPN+ (JAMM) motif; other site 568708004846 Zinc-binding site [ion binding]; other site 568708004847 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 568708004848 NlpC/P60 family; Region: NLPC_P60; cl17555 568708004850 Phage-related protein, tail component [Function unknown]; Region: COG4723 568708004852 1 probable transmembrane helix predicted for STM_MW10581 by TMHMM2.0 at aa 50-72 568708004853 Phage-related protein, tail component [Function unknown]; Region: COG4733 568708004854 Putative phage tail protein; Region: Phage-tail_3; pfam13550 568708004855 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 568708004856 Interdomain contacts; other site 568708004857 Cytokine receptor motif; other site 568708004858 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 568708004859 Fibronectin type III protein; Region: DUF3672; pfam12421 568708004862 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 568708004863 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 568708004864 Phage Tail Collar Domain; Region: Collar; pfam07484 568708004868 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 568708004873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 568708004874 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 568708004875 Integrase core domain; Region: rve; pfam00665 568708004878 hypothetical protein; Provisional; Region: PRK09951 568708004880 DinI-like family; Region: DinI; cl11630 568708004882 aminopeptidase N; Provisional; Region: pepN; PRK14015 568708004883 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 568708004884 active site 568708004885 Zn binding site [ion binding]; other site 568708004887 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 568708004888 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 568708004889 quinone interaction residues [chemical binding]; other site 568708004890 active site 568708004891 catalytic residues [active] 568708004892 FMN binding site [chemical binding]; other site 568708004893 substrate binding site [chemical binding]; other site 568708004895 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 568708004897 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 568708004898 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 568708004899 MOSC domain; Region: MOSC; pfam03473 568708004900 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568708004901 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568708004902 catalytic loop [active] 568708004903 iron binding site [ion binding]; other site 568708004907 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 568708004908 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 568708004909 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 568708004910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708004911 S-adenosylmethionine binding site [chemical binding]; other site 568708004915 ABC transporter ATPase component; Reviewed; Region: PRK11147 568708004916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708004917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708004918 Walker A/P-loop; other site 568708004919 Walker A/P-loop; other site 568708004920 ATP binding site [chemical binding]; other site 568708004921 ATP binding site [chemical binding]; other site 568708004922 Q-loop/lid; other site 568708004923 Q-loop/lid; other site 568708004924 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568708004925 ABC transporter signature motif; other site 568708004926 Walker B; other site 568708004927 D-loop; other site 568708004928 ABC transporter; Region: ABC_tran_2; pfam12848 568708004929 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568708004931 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 568708004932 Paraquat-inducible protein A; Region: PqiA; pfam04403 568708004933 Paraquat-inducible protein A; Region: PqiA; pfam04403 568708004935 8 probable transmembrane helices predicted for STM_MW10761 by TMHMM2.0 at aa 54-76, 100-122, 135-157, 162-184, 255-277, 304-326, 350-372 and 377-399 568708004936 paraquat-inducible protein B; Provisional; Region: PRK10807 568708004937 mce related protein; Region: MCE; pfam02470 568708004938 mce related protein; Region: MCE; pfam02470 568708004939 mce related protein; Region: MCE; pfam02470 568708004940 1 probable transmembrane helix predicted for STM_MW10771 by TMHMM2.0 at aa 16-38 568708004942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 568708004943 Protein of unknown function (DUF330); Region: DUF330; pfam03886 568708004944 Signal peptide predicted for STM_MW10781 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.634 between residues 19 and 20 568708004946 ribosome modulation factor; Provisional; Region: PRK14563 568708004948 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 568708004949 active site 1 [active] 568708004950 dimer interface [polypeptide binding]; other site 568708004951 active site 2 [active] 568708004953 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 568708004954 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 568708004956 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 568708004958 outer membrane protein A; Reviewed; Region: PRK10808 568708004959 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 568708004960 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568708004961 ligand binding site [chemical binding]; other site 568708004964 Signal peptide predicted for STM_MW10831 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 21 and 22 568708004965 cell division inhibitor SulA; Region: sula; TIGR00623 568708004967 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 568708004968 TfoX C-terminal domain; Region: TfoX_C; pfam04994 568708004971 TIGR01666 family membrane protein; Region: YCCS 568708004972 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 568708004973 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 568708004974 7 probable transmembrane helices predicted for STM_MW10861 by TMHMM2.0 at aa 13-35, 86-108, 115-137, 141-163, 438-460, 484-503 and 510-532 568708004976 Predicted membrane protein [Function unknown]; Region: COG3304 568708004977 Domain of unknown function (DUF307); Region: DUF307; pfam03733 568708004978 Domain of unknown function (DUF307); Region: DUF307; pfam03733 568708004980 3 probable transmembrane helices predicted for STM_MW10871 by TMHMM2.0 at aa 15-37, 77-99 and 104-126 568708004981 DNA helicase IV; Provisional; Region: helD; PRK11054 568708004982 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 568708004983 Part of AAA domain; Region: AAA_19; pfam13245 568708004984 Family description; Region: UvrD_C_2; pfam13538 568708004986 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 568708004987 active site 568708004988 dimer interfaces [polypeptide binding]; other site 568708004989 catalytic residues [active] 568708004991 hypothetical protein; Provisional; Region: PRK03641 568708004992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 568708004994 Signal peptide predicted for STM_MW10901 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 20 and 21 568708004995 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 568708004997 heat shock protein HspQ; Provisional; Region: PRK14129 568708004999 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 568708005000 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 568708005001 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 568708005002 putative RNA binding site [nucleotide binding]; other site 568708005003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708005004 S-adenosylmethionine binding site [chemical binding]; other site 568708005006 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 568708005007 substrate binding site [chemical binding]; other site 568708005008 Signal peptide predicted for STM_MW10941 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.602 between residues 21 and 22 568708005010 Cupin domain; Region: Cupin_2; cl17218 568708005011 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568708005012 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708005014 acylphosphatase; Provisional; Region: PRK14426 568708005016 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 568708005017 sulfur transfer protein TusE; Provisional; Region: PRK11508 568708005019 YccA-like proteins; Region: YccA_like; cd10433 568708005020 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 568708005022 6 probable transmembrane helices predicted for STM_MW10981 by TMHMM2.0 at aa 15-37, 49-71, 76-98, 105-127, 132-154 and 167-189 568708005023 PipA protein; Region: PipA; pfam07108 568708005025 secreted effector protein PipB; Provisional; Region: PRK15197 568708005026 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 568708005027 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 568708005028 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 568708005030 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 568708005032 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 568708005033 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 568708005037 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 568708005038 HAMP domain; Region: HAMP; pfam00672 568708005039 dimerization interface [polypeptide binding]; other site 568708005040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708005041 dimer interface [polypeptide binding]; other site 568708005042 phosphorylation site [posttranslational modification] 568708005043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708005044 ATP binding site [chemical binding]; other site 568708005045 Mg2+ binding site [ion binding]; other site 568708005046 G-X-G motif; other site 568708005048 2 probable transmembrane helices predicted for STM_MW11051 by TMHMM2.0 at aa 10-32 and 162-181 568708005050 Signal peptide predicted for STM_MW11051 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.370 between residues 31 and 32 568708005051 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 568708005052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708005053 active site 568708005054 phosphorylation site [posttranslational modification] 568708005055 intermolecular recognition site; other site 568708005056 dimerization interface [polypeptide binding]; other site 568708005057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708005058 DNA binding site [nucleotide binding] 568708005061 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 568708005062 active site 568708005063 homotetramer interface [polypeptide binding]; other site 568708005064 Signal peptide predicted for STM_MW11071 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.936 between residues 22 and 23 568708005065 1 probable transmembrane helix predicted for STM_MW11071 by TMHMM2.0 at aa 5-24 568708005067 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 568708005069 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 568708005070 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 568708005073 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 568708005074 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568708005076 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 568708005077 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 568708005078 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568708005080 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 568708005081 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 568708005082 NAD binding site [chemical binding]; other site 568708005083 catalytic residues [active] 568708005085 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 568708005086 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 568708005087 putative active site [active] 568708005088 putative metal binding site [ion binding]; other site 568708005090 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 568708005091 putative substrate binding pocket [chemical binding]; other site 568708005092 trimer interface [polypeptide binding]; other site 568708005094 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 568708005096 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 568708005098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708005099 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 568708005100 putative substrate translocation pore; other site 568708005101 12 probable transmembrane helices predicted for STM_MW11171 by TMHMM2.0 at aa 32-54, 69-88, 101-123, 133-155, 162-184, 194-216, 270-292, 305-327, 340-357, 361-383, 396-418 and 428-447 568708005103 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 568708005104 Cupin domain; Region: Cupin_2; pfam07883 568708005105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708005108 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 568708005110 anti-adapter protein IraM; Provisional; Region: PRK09919 568708005111 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 568708005112 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 568708005113 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 568708005114 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568708005115 HSP70 interaction site [polypeptide binding]; other site 568708005116 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 568708005117 substrate binding site [polypeptide binding]; other site 568708005118 dimer interface [polypeptide binding]; other site 568708005121 Signal peptide predicted for STM_MW11240 by SignalP 2.0 HMM (Signal peptide probability 0.928) with cleavage site probability 0.530 between residues 28 and 29 568708005122 2 probable transmembrane helices predicted for STM_MW11240 by TMHMM2.0 at aa 7-29 and 66-88 568708005123 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 568708005124 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 568708005125 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 568708005126 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 568708005127 DsbD alpha interface [polypeptide binding]; other site 568708005128 catalytic residues [active] 568708005129 Signal peptide predicted for STM_MW11241 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 22 and 23 568708005130 6 probable transmembrane helices predicted for STM_MW11241 by TMHMM2.0 at aa 280-302, 323-345, 360-382, 409-431, 436-458 and 479-501 568708005133 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 568708005134 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 568708005135 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 568708005136 catalytic residues [active] 568708005137 Signal peptide predicted for STM_MW11251 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 18 and 19 568708005139 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 568708005140 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 568708005141 catalytic residues [active] 568708005142 1 probable transmembrane helix predicted for STM_MW11261 by TMHMM2.0 at aa 12-29 568708005144 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 568708005145 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 568708005146 catalytic core [active] 568708005147 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 568708005148 Signal peptide predicted for STM_MW11271 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708005150 hypothetical protein; Provisional; Region: PRK10174 568708005151 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 568708005152 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568708005154 General stress protein [General function prediction only]; Region: GsiB; COG3729 568708005156 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 568708005157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708005158 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 568708005161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 568708005163 Signal peptide predicted for STM_MW11321 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 568708005164 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 568708005165 Predicted transcriptional regulator [Transcription]; Region: COG3905 568708005166 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 568708005167 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 568708005168 Glutamate binding site [chemical binding]; other site 568708005169 NAD binding site [chemical binding]; other site 568708005170 catalytic residues [active] 568708005173 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 568708005174 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 568708005175 Na binding site [ion binding]; other site 568708005176 12 probable transmembrane helices predicted for STM_MW11341 by TMHMM2.0 at aa 7-26, 66-88, 125-147, 162-184, 191-213, 233-255, 276-298, 313-335, 372-391, 401-423, 428-450 and 455-473 568708005178 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 568708005179 hypothetical protein; Provisional; Region: PRK10536 568708005181 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568708005182 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568708005183 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568708005184 putative active site [active] 568708005187 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 568708005188 Na binding site [ion binding]; other site 568708005189 13 probable transmembrane helices predicted for STM_MW11371 by TMHMM2.0 at aa 6-28, 41-63, 78-100, 120-142, 157-179, 186-208, 228-247, 280-299, 314-336, 376-398, 403-425, 432-454 and 458-480 568708005191 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 568708005192 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 568708005193 putative active site cavity [active] 568708005195 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 568708005196 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 568708005197 Signal peptide predicted for STM_MW11391 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.963 between residues 29 and 30 568708005198 1 probable transmembrane helix predicted for STM_MW11391 by TMHMM2.0 at aa 13-32 568708005200 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 568708005201 Signal peptide predicted for STM_MW11401 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708005203 putative sialic acid transporter; Provisional; Region: PRK12307 568708005204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708005205 putative substrate translocation pore; other site 568708005206 12 probable transmembrane helices predicted for STM_MW11411 by TMHMM2.0 at aa 20-42, 57-76, 88-110, 114-136, 143-165, 169-188, 230-252, 267-286, 299-316, 321-343, 360-382 and 387-409 568708005208 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568708005209 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568708005210 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568708005213 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 568708005214 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 568708005215 putative ligand binding site [chemical binding]; other site 568708005216 NAD binding site [chemical binding]; other site 568708005217 dimerization interface [polypeptide binding]; other site 568708005218 catalytic site [active] 568708005220 putative hydrolase; Validated; Region: PRK09248 568708005221 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 568708005222 active site 568708005224 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 568708005226 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 568708005227 6 probable transmembrane helices predicted for STM_MW11461 by TMHMM2.0 at aa 12-31, 36-58, 65-84, 88-110, 115-134 and 144-166 568708005229 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 568708005231 curli assembly protein CsgF; Provisional; Region: PRK10050 568708005233 1 probable transmembrane helix predicted for STM_MW11481 by TMHMM2.0 at aa 7-26 568708005234 Signal peptide predicted for STM_MW11481 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.995 between residues 19 and 20 568708005235 curli assembly protein CsgE; Provisional; Region: PRK10386 568708005237 Signal peptide predicted for STM_MW11491 by SignalP 2.0 HMM (Signal peptide probability 0.903) with cleavage site probability 0.901 between residues 22 and 23 568708005238 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 568708005239 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708005240 DNA binding residues [nucleotide binding] 568708005241 dimerization interface [polypeptide binding]; other site 568708005243 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 568708005244 Curlin associated repeat; Region: Curlin_rpt; pfam07012 568708005245 Curlin associated repeat; Region: Curlin_rpt; pfam07012 568708005246 Signal peptide predicted for STM_MW11511 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.963 between residues 21 and 22 568708005248 major curlin subunit; Provisional; Region: csgA; PRK10051 568708005249 Curlin associated repeat; Region: Curlin_rpt; pfam07012 568708005250 Signal peptide predicted for STM_MW11521 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 568708005252 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 568708005254 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 568708005255 Signal peptide predicted for STM_MW11541 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.981 between residues 25 and 26 568708005256 1 probable transmembrane helix predicted for STM_MW11541 by TMHMM2.0 at aa 7-29 568708005257 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 568708005258 putative ADP-ribose binding site [chemical binding]; other site 568708005259 putative active site [active] 568708005261 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 568708005262 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 568708005263 putative active site [active] 568708005264 catalytic site [active] 568708005265 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 568708005266 putative active site [active] 568708005267 catalytic site [active] 568708005268 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 568708005269 Acyltransferase family; Region: Acyl_transf_3; pfam01757 568708005271 10 probable transmembrane helices predicted for STM_MW11571 by TMHMM2.0 at aa 17-39, 54-76, 88-110, 138-160, 181-203, 213-232, 245-262, 277-299, 306-328 and 338-360 568708005272 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 568708005273 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 568708005274 Signal peptide predicted for STM_MW11581 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 22 and 23 568708005276 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 568708005277 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 568708005278 Ligand binding site; other site 568708005279 DXD motif; other site 568708005280 6 probable transmembrane helices predicted for STM_MW11591 by TMHMM2.0 at aa 139-156, 194-216, 512-534, 568-590, 603-625 and 680-702 568708005282 lipoprotein; Provisional; Region: PRK10175 568708005284 secY/secA suppressor protein; Provisional; Region: PRK11467 568708005285 drug efflux system protein MdtG; Provisional; Region: PRK09874 568708005286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708005287 putative substrate translocation pore; other site 568708005288 11 probable transmembrane helices predicted for STM_MW11621 by TMHMM2.0 at aa 15-37, 49-68, 83-101, 108-130, 140-162, 169-191, 222-244, 251-273, 288-306, 313-335 and 371-393 568708005290 Signal peptide predicted for STM_MW11621 by SignalP 2.0 HMM (Signal peptide probability 0.641) with cleavage site probability 0.479 between residues 29 and 30 568708005291 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 568708005292 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 568708005293 putative acyl-acceptor binding pocket; other site 568708005295 2 probable transmembrane helices predicted for STM_MW11631 by TMHMM2.0 at aa 20-42 and 123-145 568708005296 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 568708005297 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 568708005298 active site residue [active] 568708005300 hypothetical protein; Provisional; Region: PRK03757 568708005302 Signal peptide predicted for STM_MW11651 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23 568708005303 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 568708005305 4 probable transmembrane helices predicted for STM_MW11661 by TMHMM2.0 at aa 13-35, 55-72, 92-114 and 147-169 568708005306 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 568708005307 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568708005309 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 568708005310 DNA damage-inducible protein I; Provisional; Region: PRK10597 568708005312 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 568708005313 active site 568708005314 substrate binding pocket [chemical binding]; other site 568708005315 dimer interface [polypeptide binding]; other site 568708005316 lipoprotein; Provisional; Region: PRK10598 568708005318 Signal peptide predicted for STM_MW11721 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.483 between residues 18 and 19 568708005319 glutaredoxin 2; Provisional; Region: PRK10387 568708005320 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 568708005321 C-terminal domain interface [polypeptide binding]; other site 568708005322 GSH binding site (G-site) [chemical binding]; other site 568708005323 catalytic residues [active] 568708005324 putative dimer interface [polypeptide binding]; other site 568708005325 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 568708005326 N-terminal domain interface [polypeptide binding]; other site 568708005328 multidrug resistance protein MdtH; Provisional; Region: PRK11646 568708005329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708005330 putative substrate translocation pore; other site 568708005331 10 probable transmembrane helices predicted for STM_MW11741 by TMHMM2.0 at aa 13-35, 99-116, 136-158, 163-185, 210-232, 247-264, 277-295, 300-322, 335-357 and 367-389 568708005333 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 568708005334 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 568708005336 hypothetical protein; Provisional; Region: PRK11239 568708005337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 568708005339 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568708005340 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568708005341 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568708005344 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 568708005345 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 568708005346 13 probable transmembrane helices predicted for STM_MW11781 by TMHMM2.0 at aa 39-58, 95-117, 143-165, 172-194, 199-221, 250-272, 287-309, 322-341, 361-383, 396-415, 420-442, 454-476 and 491-513 568708005348 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 568708005350 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 568708005352 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 568708005353 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 568708005354 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 568708005356 Signal peptide predicted for STM_MW11811 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 21 and 22 568708005357 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 568708005358 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 568708005360 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 568708005361 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 568708005362 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 568708005365 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 568708005366 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 568708005367 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 568708005369 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 568708005370 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 568708005371 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 568708005372 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 568708005376 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 568708005377 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 568708005378 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 568708005381 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 568708005382 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 568708005383 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 568708005386 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 568708005387 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 568708005388 1 probable transmembrane helix predicted for STM_MW11881 by TMHMM2.0 at aa 5-27 568708005390 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 568708005391 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 568708005392 Signal peptide predicted for STM_MW11891 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.996 between residues 19 and 20 568708005394 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 568708005395 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 568708005396 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 568708005399 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 568708005400 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 568708005403 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 568708005404 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 568708005406 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 568708005407 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 568708005408 homodimer interface [polypeptide binding]; other site 568708005409 oligonucleotide binding site [chemical binding]; other site 568708005410 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 568708005413 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 568708005415 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 568708005416 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568708005417 RNA binding surface [nucleotide binding]; other site 568708005418 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568708005419 active site 568708005422 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 568708005424 Maf-like protein; Region: Maf; pfam02545 568708005425 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 568708005426 active site 568708005427 dimer interface [polypeptide binding]; other site 568708005429 hypothetical protein; Provisional; Region: PRK11193 568708005431 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 568708005433 putative phosphate acyltransferase; Provisional; Region: PRK05331 568708005435 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 568708005436 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 568708005437 dimer interface [polypeptide binding]; other site 568708005438 active site 568708005439 CoA binding pocket [chemical binding]; other site 568708005442 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 568708005443 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 568708005445 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 568708005446 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 568708005447 NAD(P) binding site [chemical binding]; other site 568708005448 homotetramer interface [polypeptide binding]; other site 568708005449 homodimer interface [polypeptide binding]; other site 568708005450 active site 568708005452 acyl carrier protein; Provisional; Region: acpP; PRK00982 568708005454 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 568708005455 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 568708005456 dimer interface [polypeptide binding]; other site 568708005457 active site 568708005460 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 568708005461 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 568708005462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708005463 catalytic residue [active] 568708005465 conserved hypothetical protein, YceG family; Region: TIGR00247 568708005466 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 568708005467 dimerization interface [polypeptide binding]; other site 568708005469 thymidylate kinase; Validated; Region: tmk; PRK00698 568708005470 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 568708005471 TMP-binding site; other site 568708005472 ATP-binding site [chemical binding]; other site 568708005474 DNA polymerase III subunit delta'; Validated; Region: PRK07993 568708005475 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 568708005477 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 568708005478 active site 568708005480 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 568708005481 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568708005482 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568708005483 active site turn [active] 568708005484 phosphorylation site [posttranslational modification] 568708005486 9 probable transmembrane helices predicted for STM_MW12121 by TMHMM2.0 at aa 15-37, 49-71, 81-103, 116-138, 153-175, 248-270, 280-302, 309-331 and 354-376 568708005488 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 568708005489 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568708005490 N-terminal plug; other site 568708005491 ligand-binding site [chemical binding]; other site 568708005494 Signal peptide predicted for STM_MW12131 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 35 and 36 568708005495 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 568708005496 nucleotide binding site/active site [active] 568708005497 HIT family signature motif; other site 568708005498 catalytic residue [active] 568708005500 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 568708005501 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 568708005502 putative dimer interface [polypeptide binding]; other site 568708005503 Signal peptide predicted for STM_MW12151 by SignalP 2.0 HMM (Signal peptide probability 0.650) with cleavage site probability 0.635 between residues 20 and 21 568708005505 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 568708005506 Signal peptide predicted for STM_MW12161 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 22 and 23 568708005507 thiamine kinase; Region: ycfN_thiK; TIGR02721 568708005508 thiamine kinase; Provisional; Region: thiK; PRK10271 568708005509 substrate binding site [chemical binding]; other site 568708005511 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 568708005512 beta-hexosaminidase; Provisional; Region: PRK05337 568708005514 hypothetical protein; Provisional; Region: PRK04940 568708005516 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 568708005517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568708005520 hypothetical protein; Provisional; Region: PRK11280 568708005521 Signal peptide predicted for STM_MW12211 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.671 between residues 23 and 24 568708005522 1 probable transmembrane helix predicted for STM_MW12211 by TMHMM2.0 at aa 5-27 568708005524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568708005525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708005527 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 568708005528 Signal peptide predicted for STM_MW12231 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.973 between residues 22 and 23 568708005529 1 probable transmembrane helix predicted for STM_MW12231 by TMHMM2.0 at aa 7-29 568708005531 L,D-transpeptidase; Provisional; Region: PRK10190 568708005532 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568708005533 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568708005536 1 probable transmembrane helix predicted for STM_MW12241 by TMHMM2.0 at aa 7-29 568708005537 Signal peptide predicted for STM_MW12241 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 28 and 29 568708005538 transcription-repair coupling factor; Provisional; Region: PRK10689 568708005539 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 568708005540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568708005541 ATP binding site [chemical binding]; other site 568708005542 putative Mg++ binding site [ion binding]; other site 568708005543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708005544 nucleotide binding region [chemical binding]; other site 568708005545 ATP-binding site [chemical binding]; other site 568708005546 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 568708005551 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 568708005552 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568708005553 FtsX-like permease family; Region: FtsX; pfam02687 568708005554 4 probable transmembrane helices predicted for STM_MW12261 by TMHMM2.0 at aa 62-84, 303-325, 355-377 and 397-419 568708005556 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 568708005557 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568708005558 Walker A/P-loop; other site 568708005559 ATP binding site [chemical binding]; other site 568708005560 Q-loop/lid; other site 568708005561 ABC transporter signature motif; other site 568708005562 Walker B; other site 568708005563 D-loop; other site 568708005564 H-loop/switch region; other site 568708005566 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 568708005567 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568708005568 FtsX-like permease family; Region: FtsX; pfam02687 568708005569 4 probable transmembrane helices predicted for STM_MW12281 by TMHMM2.0 at aa 21-43, 270-292, 318-340 and 375-397 568708005571 fructokinase; Reviewed; Region: PRK09557 568708005572 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568708005573 nucleotide binding site [chemical binding]; other site 568708005575 NAD-dependent deacetylase; Provisional; Region: PRK00481 568708005576 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 568708005577 NAD+ binding site [chemical binding]; other site 568708005578 substrate binding site [chemical binding]; other site 568708005579 Zn binding site [ion binding]; other site 568708005581 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 568708005582 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 568708005584 Signal peptide predicted for STM_MW12311 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 568708005585 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568708005586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708005587 dimer interface [polypeptide binding]; other site 568708005588 conserved gate region; other site 568708005589 putative PBP binding loops; other site 568708005590 ABC-ATPase subunit interface; other site 568708005591 6 probable transmembrane helices predicted for STM_MW12321 by TMHMM2.0 at aa 5-27, 64-86, 99-121, 126-148, 176-195 and 230-252 568708005593 Sif protein; Region: Sif; pfam06767 568708005595 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568708005596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708005597 dimer interface [polypeptide binding]; other site 568708005598 conserved gate region; other site 568708005599 putative PBP binding loops; other site 568708005600 ABC-ATPase subunit interface; other site 568708005601 6 probable transmembrane helices predicted for STM_MW12341 by TMHMM2.0 at aa 9-31, 69-91, 98-120, 151-173, 194-216 and 250-272 568708005603 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 568708005604 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708005605 Walker A/P-loop; other site 568708005606 ATP binding site [chemical binding]; other site 568708005607 Q-loop/lid; other site 568708005608 ABC transporter signature motif; other site 568708005609 Walker B; other site 568708005610 D-loop; other site 568708005611 H-loop/switch region; other site 568708005612 TOBE domain; Region: TOBE_2; pfam08402 568708005615 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 568708005616 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 568708005617 metal binding site [ion binding]; metal-binding site 568708005618 dimer interface [polypeptide binding]; other site 568708005621 Signal peptide; signalp; query 1-26;cleavage_site_probability=0.983; 0.983 568708005622 Transposase IS200 like; Region: Y1_Tnp; pfam01797 568708005624 Uncharacterized conserved protein [Function unknown]; Region: COG2850 568708005625 Cupin-like domain; Region: Cupin_8; pfam13621 568708005627 sensor protein PhoQ; Provisional; Region: PRK10815 568708005628 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 568708005629 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 568708005630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708005631 ATP binding site [chemical binding]; other site 568708005632 Mg2+ binding site [ion binding]; other site 568708005633 G-X-G motif; other site 568708005636 2 probable transmembrane helices predicted for STM_MW12401 by TMHMM2.0 at aa 20-42 and 194-216 568708005638 Signal peptide predicted for STM_MW12401 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.297 between residues 31 and 32 568708005639 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 568708005640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708005641 active site 568708005642 phosphorylation site [posttranslational modification] 568708005643 intermolecular recognition site; other site 568708005644 dimerization interface [polypeptide binding]; other site 568708005645 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708005646 DNA binding site [nucleotide binding] 568708005649 adenylosuccinate lyase; Provisional; Region: PRK09285 568708005650 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 568708005651 tetramer interface [polypeptide binding]; other site 568708005652 active site 568708005655 putative lysogenization regulator; Reviewed; Region: PRK00218 568708005657 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 568708005658 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 568708005660 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 568708005661 nudix motif; other site 568708005663 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 568708005664 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 568708005666 Signal peptide predicted for STM_MW12461 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 18 and 19 568708005667 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 568708005668 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 568708005669 probable active site [active] 568708005671 isocitrate dehydrogenase; Validated; Region: PRK07362 568708005672 isocitrate dehydrogenase; Reviewed; Region: PRK07006 568708005674 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 568708005675 Signal peptide predicted for STM_MW12501 by SignalP 2.0 HMM (Signal peptide probability 0.963) with cleavage site probability 0.957 between residues 25 and 26 568708005676 DinI-like family; Region: DinI; pfam06183 568708005678 Ricin-type beta-trefoil; Region: RICIN; smart00458 568708005679 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 568708005680 putative sugar binding sites [chemical binding]; other site 568708005681 Q-X-W motif; other site 568708005683 Signal peptide predicted for STM_MW12521 by SignalP 2.0 HMM (Signal peptide probability 0.921) with cleavage site probability 0.763 between residues 25 and 26 568708005684 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568708005685 DNA-binding site [nucleotide binding]; DNA binding site 568708005686 RNA-binding motif; other site 568708005688 Signal peptide predicted for STM_MW12541 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.993 between residues 20 and 21 568708005689 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 568708005691 lysozyme inhibitor; Provisional; Region: PRK13791 568708005693 Signal peptide predicted for STM_MW12561 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.928 between residues 24 and 25 568708005694 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 568708005695 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 568708005696 putative dimer interface [polypeptide binding]; other site 568708005698 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 568708005699 BNR repeat-like domain; Region: BNR_2; pfam13088 568708005700 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 568708005702 4 probable transmembrane helices predicted for STM_MW12601 by TMHMM2.0 at aa 9-31, 46-63, 88-110 and 140-162 568708005703 Signal peptide predicted for STM_MW12601 by SignalP 2.0 HMM (Signal peptide probability 0.893) with cleavage site probability 0.892 between residues 24 and 25 568708005704 TRL-like protein family; Region: TRL; pfam13146 568708005705 1 probable transmembrane helix predicted for STM_MW12611 by TMHMM2.0 at aa 7-29 568708005706 Signal peptide predicted for STM_MW12611 by SignalP 2.0 HMM (Signal peptide probability 0.738) with cleavage site probability 0.321 between residues 28 and 29 568708005707 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 568708005708 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 568708005709 Signal peptide predicted for STM_MW12621 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.976 between residues 39 and 40 568708005710 1 probable transmembrane helix predicted for STM_MW12621 by TMHMM2.0 at aa 21-40 568708005712 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568708005713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708005714 dimer interface [polypeptide binding]; other site 568708005715 conserved gate region; other site 568708005716 ABC-ATPase subunit interface; other site 568708005717 Signal peptide predicted for STM_MW12631 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.944 between residues 27 and 28 568708005718 4 probable transmembrane helices predicted for STM_MW12631 by TMHMM2.0 at aa 7-29, 104-126, 139-161 and 291-313 568708005720 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568708005721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708005722 dimer interface [polypeptide binding]; other site 568708005723 conserved gate region; other site 568708005724 putative PBP binding loops; other site 568708005725 ABC-ATPase subunit interface; other site 568708005726 Signal peptide predicted for STM_MW12641 by SignalP 2.0 HMM (Signal peptide probability 0.966) with cleavage site probability 0.858 between residues 28 and 29 568708005727 4 probable transmembrane helices predicted for STM_MW12641 by TMHMM2.0 at aa 7-29, 74-96, 117-139 and 236-253 568708005729 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568708005730 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 568708005731 Walker A/P-loop; other site 568708005732 ATP binding site [chemical binding]; other site 568708005733 Q-loop/lid; other site 568708005734 ABC transporter signature motif; other site 568708005735 Walker B; other site 568708005736 D-loop; other site 568708005737 H-loop/switch region; other site 568708005739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708005740 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 568708005741 Walker A/P-loop; other site 568708005742 ATP binding site [chemical binding]; other site 568708005743 Q-loop/lid; other site 568708005744 ABC transporter signature motif; other site 568708005745 Walker B; other site 568708005746 D-loop; other site 568708005747 H-loop/switch region; other site 568708005749 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 568708005750 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568708005752 5 probable transmembrane helices predicted for STM_MW12671 by TMHMM2.0 at aa 20-42, 74-90, 97-114, 136-158 and 165-187 568708005753 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 568708005754 dimerization interface [polypeptide binding]; other site 568708005756 zinc/cadmium-binding protein; Provisional; Region: PRK10306 568708005757 Signal peptide predicted for STM_MW12691 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.968 between residues 22 and 23 568708005759 aminoglycoside resistance protein; Provisional; Region: PRK13746 568708005760 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 568708005761 active site 568708005762 NTP binding site [chemical binding]; other site 568708005763 metal binding triad [ion binding]; metal-binding site 568708005764 antibiotic binding site [chemical binding]; other site 568708005765 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 568708005767 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708005768 DNA binding residues [nucleotide binding] 568708005770 transcriptional regulator MirA; Provisional; Region: PRK15043 568708005771 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 568708005772 DNA binding residues [nucleotide binding] 568708005773 dimer interface [polypeptide binding]; other site 568708005775 Pleckstrin homology-like domain; Region: PH-like; cl17171 568708005776 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 568708005778 chorismate mutase; Provisional; Region: PRK08055 568708005779 Signal peptide predicted for STM_MW12751 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 20 and 21 568708005781 leucine export protein LeuE; Provisional; Region: PRK10958 568708005782 6 probable transmembrane helices predicted for STM_MW12761 by TMHMM2.0 at aa 10-32, 45-67, 77-99, 120-142, 157-179 and 191-210 568708005784 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 568708005786 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 568708005788 Signal peptide predicted for STM_MW12791 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.900 between residues 24 and 25 568708005789 4 probable transmembrane helices predicted for STM_MW12791 by TMHMM2.0 at aa 7-25, 40-59, 71-90 and 100-122 568708005790 hypothetical protein; Provisional; Region: PRK10457 568708005791 3 probable transmembrane helices predicted for STM_MW12811 by TMHMM2.0 at aa 4-21, 28-50 and 60-77 568708005793 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 568708005794 murein hydrolase B; Provisional; Region: PRK10760; cl17906 568708005795 Domain of unknown function (DUF333); Region: DUF333; pfam03891 568708005797 Uncharacterized conserved protein [Function unknown]; Region: COG3189 568708005799 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 568708005800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708005801 12 probable transmembrane helices predicted for STM_MW12851 by TMHMM2.0 at aa 12-31, 46-68, 81-98, 103-125, 137-159, 163-185, 217-239, 249-271, 278-297, 302-324, 333-355 and 365-387 568708005803 Signal peptide predicted for STM_MW12851 by SignalP 2.0 HMM (Signal peptide probability 0.638) with cleavage site probability 0.471 between residues 33 and 34 568708005804 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568708005805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708005808 Predicted membrane protein [Function unknown]; Region: COG2707 568708005809 4 probable transmembrane helices predicted for STM_MW12862 by TMHMM2.0 at aa 12-34, 49-71, 76-98 and 124-146 568708005811 Signal peptide predicted for STM_MW12862 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.511 between residues 24 and 25 568708005812 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 568708005813 putative deacylase active site [active] 568708005815 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568708005816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568708005817 metal binding site [ion binding]; metal-binding site 568708005818 active site 568708005819 I-site; other site 568708005820 2 probable transmembrane helices predicted for STM_MW12891 by TMHMM2.0 at aa 7-29 and 305-327 568708005822 hypothetical protein; Provisional; Region: PRK05325 568708005824 PrkA family serine protein kinase; Provisional; Region: PRK15455 568708005825 AAA ATPase domain; Region: AAA_16; pfam13191 568708005826 Walker A motif; other site 568708005827 ATP binding site [chemical binding]; other site 568708005828 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 568708005831 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 568708005832 Signal peptide predicted for STM_MW12921 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 22 and 23 568708005834 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 568708005835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708005836 FeS/SAM binding site; other site 568708005837 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 568708005839 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568708005840 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568708005841 active site 568708005842 catalytic tetrad [active] 568708005844 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 568708005845 active site 568708005846 phosphate binding residues; other site 568708005847 catalytic residues [active] 568708005849 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 568708005850 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 568708005851 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 568708005854 methionine sulfoxide reductase B; Provisional; Region: PRK00222 568708005855 SelR domain; Region: SelR; pfam01641 568708005857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 568708005859 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 568708005860 Isochorismatase family; Region: Isochorismatase; pfam00857 568708005861 catalytic triad [active] 568708005862 metal binding site [ion binding]; metal-binding site 568708005863 conserved cis-peptide bond; other site 568708005865 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 568708005866 active site 568708005867 homodimer interface [polypeptide binding]; other site 568708005869 protease 4; Provisional; Region: PRK10949 568708005870 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 568708005871 tandem repeat interface [polypeptide binding]; other site 568708005872 oligomer interface [polypeptide binding]; other site 568708005873 active site residues [active] 568708005874 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 568708005875 tandem repeat interface [polypeptide binding]; other site 568708005876 oligomer interface [polypeptide binding]; other site 568708005877 active site residues [active] 568708005879 1 probable transmembrane helix predicted for STM_MW13021 by TMHMM2.0 at aa 21-43 568708005880 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 568708005881 putative FMN binding site [chemical binding]; other site 568708005883 selenophosphate synthetase; Provisional; Region: PRK00943 568708005884 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 568708005885 dimerization interface [polypeptide binding]; other site 568708005886 putative ATP binding site [chemical binding]; other site 568708005889 DNA topoisomerase III; Provisional; Region: PRK07726 568708005890 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 568708005891 active site 568708005892 putative interdomain interaction site [polypeptide binding]; other site 568708005893 putative metal-binding site [ion binding]; other site 568708005894 putative nucleotide binding site [chemical binding]; other site 568708005895 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 568708005896 domain I; other site 568708005897 DNA binding groove [nucleotide binding] 568708005898 phosphate binding site [ion binding]; other site 568708005899 domain II; other site 568708005900 domain III; other site 568708005901 nucleotide binding site [chemical binding]; other site 568708005902 catalytic site [active] 568708005903 domain IV; other site 568708005906 glutamate dehydrogenase; Provisional; Region: PRK09414 568708005907 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 568708005908 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 568708005909 NAD(P) binding site [chemical binding]; other site 568708005912 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 568708005913 Signal peptide predicted for STM_MW13071 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.921 between residues 19 and 20 568708005915 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 568708005916 active site 568708005917 8-oxo-dGMP binding site [chemical binding]; other site 568708005918 nudix motif; other site 568708005919 metal binding site [ion binding]; metal-binding site 568708005921 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 568708005922 putative catalytic site [active] 568708005923 putative phosphate binding site [ion binding]; other site 568708005924 active site 568708005925 metal binding site A [ion binding]; metal-binding site 568708005926 DNA binding site [nucleotide binding] 568708005927 putative AP binding site [nucleotide binding]; other site 568708005928 putative metal binding site B [ion binding]; other site 568708005930 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 568708005931 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568708005932 inhibitor-cofactor binding pocket; inhibition site 568708005933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708005934 catalytic residue [active] 568708005936 arginine succinyltransferase; Provisional; Region: PRK10456 568708005937 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 568708005939 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 568708005940 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 568708005941 NAD(P) binding site [chemical binding]; other site 568708005942 catalytic residues [active] 568708005944 succinylarginine dihydrolase; Provisional; Region: PRK13281 568708005946 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 568708005947 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 568708005948 putative active site [active] 568708005949 Zn binding site [ion binding]; other site 568708005951 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 568708005952 dimer interface [polypeptide binding]; other site 568708005953 Signal peptide predicted for STM_MW13151 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 568708005955 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 568708005956 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 568708005957 GIY-YIG motif/motif A; other site 568708005958 active site 568708005959 catalytic site [active] 568708005960 putative DNA binding site [nucleotide binding]; other site 568708005961 metal binding site [ion binding]; metal-binding site 568708005963 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 568708005964 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 568708005965 homodimer interface [polypeptide binding]; other site 568708005966 NAD binding pocket [chemical binding]; other site 568708005967 ATP binding pocket [chemical binding]; other site 568708005968 Mg binding site [ion binding]; other site 568708005969 active-site loop [active] 568708005971 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 568708005972 Signal peptide predicted for STM_MW13181 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.918 between residues 23 and 24 568708005974 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 568708005975 active site 568708005976 P-loop; other site 568708005977 phosphorylation site [posttranslational modification] 568708005978 Signal peptide predicted for STM_MW13191 by SignalP 2.0 HMM (Signal peptide probability 0.688) with cleavage site probability 0.538 between residues 27 and 28 568708005980 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 568708005981 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 568708005983 10 probable transmembrane helices predicted for STM_MW13201 by TMHMM2.0 at aa 31-53, 85-107, 114-133, 143-165, 186-208, 232-254, 302-321, 341-363, 370-392 and 407-429 568708005984 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568708005985 methionine cluster; other site 568708005986 active site 568708005987 phosphorylation site [posttranslational modification] 568708005988 metal binding site [ion binding]; metal-binding site 568708005990 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 568708005991 Cupin domain; Region: Cupin_2; pfam07883 568708005992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708005995 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 568708005996 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 568708005997 NAD binding site [chemical binding]; other site 568708005998 sugar binding site [chemical binding]; other site 568708005999 divalent metal binding site [ion binding]; other site 568708006000 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568708006001 dimer interface [polypeptide binding]; other site 568708006003 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 568708006004 putative active site [active] 568708006005 YdjC motif; other site 568708006006 Mg binding site [ion binding]; other site 568708006007 putative homodimer interface [polypeptide binding]; other site 568708006009 hydroperoxidase II; Provisional; Region: katE; PRK11249 568708006010 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 568708006011 tetramer interface [polypeptide binding]; other site 568708006012 heme binding pocket [chemical binding]; other site 568708006013 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 568708006014 domain interactions; other site 568708006017 cell division modulator; Provisional; Region: PRK10113 568708006019 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 568708006020 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 568708006022 9 probable transmembrane helices predicted for STM_MW13271 by TMHMM2.0 at aa 5-22, 34-51, 71-93, 105-127, 180-202, 260-282, 340-362, 369-391 and 395-417 568708006023 Signal peptide predicted for STM_MW13271 by SignalP 2.0 HMM (Signal peptide probability 0.887) with cleavage site probability 0.343 between residues 20 and 21 568708006024 inner membrane protein; Provisional; Region: PRK11648 568708006026 2 probable transmembrane helices predicted for STM_MW13281 by TMHMM2.0 at aa 72-94 and 109-131 568708006027 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 568708006028 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568708006029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708006030 motif II; other site 568708006032 YniB-like protein; Region: YniB; pfam14002 568708006033 3 probable transmembrane helices predicted for STM_MW13301 by TMHMM2.0 at aa 16-38, 79-101 and 150-172 568708006034 Phosphotransferase enzyme family; Region: APH; pfam01636 568708006035 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 568708006036 active site 568708006037 ATP binding site [chemical binding]; other site 568708006038 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 568708006040 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 568708006042 6-phosphofructokinase 2; Provisional; Region: PRK10294 568708006043 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568708006044 putative substrate binding site [chemical binding]; other site 568708006045 putative ATP binding site [chemical binding]; other site 568708006047 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 568708006048 Signal peptide predicted for STM_MW13341 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.805 between residues 25 and 26 568708006049 1 probable transmembrane helix predicted for STM_MW13341 by TMHMM2.0 at aa 7-24 568708006051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 568708006053 Signal peptide predicted for STM_MW13351 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.734 between residues 23 and 24 568708006054 2 probable transmembrane helices predicted for STM_MW13361 by TMHMM2.0 at aa 33-55 and 59-81 568708006055 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 568708006056 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 568708006057 active site 568708006058 substrate binding site [chemical binding]; other site 568708006059 Mg2+ binding site [ion binding]; other site 568708006061 11 probable transmembrane helices predicted for STM_MW13391 by TMHMM2.0 at aa 4-24, 31-53, 63-82, 102-121, 141-163, 168-185, 190-204, 211-233, 321-343, 355-377 and 381-403 568708006062 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 568708006063 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 568708006064 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 568708006065 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 568708006066 active site 568708006067 dimer interface [polypeptide binding]; other site 568708006068 motif 1; other site 568708006069 motif 2; other site 568708006070 motif 3; other site 568708006071 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 568708006072 anticodon binding site; other site 568708006077 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 568708006078 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 568708006079 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 568708006082 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 568708006084 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 568708006085 23S rRNA binding site [nucleotide binding]; other site 568708006086 L21 binding site [polypeptide binding]; other site 568708006087 L13 binding site [polypeptide binding]; other site 568708006089 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 568708006090 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 568708006091 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 568708006092 dimer interface [polypeptide binding]; other site 568708006093 motif 1; other site 568708006094 active site 568708006095 motif 2; other site 568708006096 motif 3; other site 568708006099 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 568708006100 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 568708006101 putative tRNA-binding site [nucleotide binding]; other site 568708006102 B3/4 domain; Region: B3_4; pfam03483 568708006103 tRNA synthetase B5 domain; Region: B5; smart00874 568708006104 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 568708006105 dimer interface [polypeptide binding]; other site 568708006106 motif 1; other site 568708006107 motif 3; other site 568708006108 motif 2; other site 568708006109 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 568708006114 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568708006115 IHF dimer interface [polypeptide binding]; other site 568708006116 IHF - DNA interface [nucleotide binding]; other site 568708006118 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 568708006119 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568708006120 ABC-ATPase subunit interface; other site 568708006121 dimer interface [polypeptide binding]; other site 568708006122 putative PBP binding regions; other site 568708006123 Signal peptide predicted for STM_MW13471 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.950 between residues 36 and 37 568708006124 9 probable transmembrane helices predicted for STM_MW13471 by TMHMM2.0 at aa 20-42, 62-84, 91-110, 114-136, 149-171, 191-208, 245-267, 277-299 and 306-325 568708006126 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 568708006127 catalytic residues [active] 568708006128 dimer interface [polypeptide binding]; other site 568708006130 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 568708006131 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 568708006132 Walker A/P-loop; other site 568708006133 ATP binding site [chemical binding]; other site 568708006134 Q-loop/lid; other site 568708006135 ABC transporter signature motif; other site 568708006136 Walker B; other site 568708006137 D-loop; other site 568708006138 H-loop/switch region; other site 568708006140 NlpC/P60 family; Region: NLPC_P60; pfam00877 568708006141 Signal peptide predicted for STM_MW13501 by SignalP 2.0 HMM (Signal peptide probability 0.714) with cleavage site probability 0.492 between residues 26 and 27 568708006143 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 568708006145 Uncharacterized conserved protein [Function unknown]; Region: COG0397 568708006146 hypothetical protein; Validated; Region: PRK00029 568708006148 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 568708006150 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 568708006151 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 568708006153 PEP synthetase regulatory protein; Provisional; Region: PRK05339 568708006155 phosphoenolpyruvate synthase; Validated; Region: PRK06464 568708006156 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 568708006157 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568708006158 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568708006162 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 568708006163 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 568708006164 acyl-activating enzyme (AAE) consensus motif; other site 568708006165 putative AMP binding site [chemical binding]; other site 568708006166 putative active site [active] 568708006167 putative CoA binding site [chemical binding]; other site 568708006169 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 568708006170 oxidoreductase; Provisional; Region: PRK10015 568708006172 Signal peptide predicted for STM_MW13591 by SignalP 2.0 HMM (Signal peptide probability 0.711) with cleavage site probability 0.694 between residues 25 and 26 568708006173 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 568708006174 Electron transfer flavoprotein domain; Region: ETF; smart00893 568708006175 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 568708006178 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 568708006179 Ligand binding site [chemical binding]; other site 568708006180 Electron transfer flavoprotein domain; Region: ETF; pfam01012 568708006182 Cupin domain; Region: Cupin_2; pfam07883 568708006183 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568708006184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708006187 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 568708006188 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 568708006189 active site 568708006193 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 568708006194 Coenzyme A transferase; Region: CoA_trans; smart00882 568708006195 Coenzyme A transferase; Region: CoA_trans; cl17247 568708006197 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 568708006198 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 568708006199 active site 568708006200 catalytic residue [active] 568708006201 dimer interface [polypeptide binding]; other site 568708006203 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 568708006204 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568708006205 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568708006206 shikimate binding site; other site 568708006207 NAD(P) binding site [chemical binding]; other site 568708006210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708006211 putative transporter; Provisional; Region: PRK03699 568708006212 putative substrate translocation pore; other site 568708006214 12 probable transmembrane helices predicted for STM_MW13671 by TMHMM2.0 at aa 12-34, 49-71, 78-97, 101-118, 138-160, 164-186, 212-234, 254-273, 280-298, 308-330, 343-365 and 370-392 568708006215 Signal peptide predicted for STM_MW13671 by SignalP 2.0 HMM (Signal peptide probability 0.826) with cleavage site probability 0.803 between residues 33 and 34 568708006216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708006217 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568708006218 putative substrate translocation pore; other site 568708006220 11 probable transmembrane helices predicted for STM_MW13681 by TMHMM2.0 at aa 9-31, 41-63, 75-97, 133-155, 160-179, 207-229, 250-269, 273-295, 300-322, 337-356 and 363-385 568708006221 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 568708006223 putative inner membrane protein; Provisional; Region: PRK10983 568708006224 Domain of unknown function DUF20; Region: UPF0118; pfam01594 568708006226 8 probable transmembrane helices predicted for STM_MW13701 by TMHMM2.0 at aa 13-32, 36-53, 65-87, 159-181, 202-224, 237-259, 266-288 and 308-330 568708006227 Signal peptide predicted for STM_MW13701 by SignalP 2.0 HMM (Signal peptide probability 0.608) with cleavage site probability 0.597 between residues 41 and 42 568708006228 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 568708006229 FAD binding domain; Region: FAD_binding_4; pfam01565 568708006230 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 568708006233 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568708006234 CoenzymeA binding site [chemical binding]; other site 568708006235 subunit interaction site [polypeptide binding]; other site 568708006236 PHB binding site; other site 568708006238 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 568708006239 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 568708006241 11 probable transmembrane helices predicted for STM_MW13741 by TMHMM2.0 at aa 4-19, 32-51, 66-88, 101-123, 170-192, 220-242, 252-274, 286-308, 336-353, 358-380 and 384-406 568708006242 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 568708006244 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 568708006245 putative ABC transporter; Region: ycf24; CHL00085 568708006247 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 568708006248 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 568708006249 Walker A/P-loop; other site 568708006250 ATP binding site [chemical binding]; other site 568708006251 Q-loop/lid; other site 568708006252 ABC transporter signature motif; other site 568708006253 Walker B; other site 568708006254 D-loop; other site 568708006255 H-loop/switch region; other site 568708006257 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 568708006258 FeS assembly protein SufD; Region: sufD; TIGR01981 568708006260 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 568708006261 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 568708006262 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568708006263 catalytic residue [active] 568708006265 cysteine desufuration protein SufE; Provisional; Region: PRK09296 568708006267 L,D-transpeptidase; Provisional; Region: PRK10190 568708006268 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568708006269 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568708006270 Signal peptide predicted for STM_MW13811 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.697 between residues 23 and 24 568708006273 pyruvate kinase; Provisional; Region: PRK09206 568708006274 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 568708006275 active site 568708006276 domain interfaces; other site 568708006279 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568708006280 13 probable transmembrane helices predicted for STM_MW13841 by TMHMM2.0 at aa 10-32, 39-61, 71-93, 95-114, 119-138, 147-169, 184-206, 227-249, 273-295, 330-347, 357-379, 386-405 and 409-428 568708006282 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 568708006284 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 568708006286 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568708006287 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568708006288 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568708006289 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 568708006290 substrate binding site [chemical binding]; other site 568708006291 dimer interface [polypeptide binding]; other site 568708006292 ATP binding site [chemical binding]; other site 568708006295 tetrathionate reductase subunit A; Provisional; Region: PRK14991 568708006296 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 568708006297 putative [Fe4-S4] binding site [ion binding]; other site 568708006298 putative molybdopterin cofactor binding site [chemical binding]; other site 568708006299 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 568708006300 putative molybdopterin cofactor binding site; other site 568708006303 tetrathionate reductase subunit C; Provisional; Region: PRK14992 568708006304 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 568708006306 9 probable transmembrane helices predicted for STM_MW13891 by TMHMM2.0 at aa 23-45, 58-77, 92-114, 126-148, 163-185, 197-216, 236-255, 267-289 and 309-326 568708006307 tetrathionate reductase subunit B; Provisional; Region: PRK14993 568708006308 4Fe-4S binding domain; Region: Fer4; pfam00037 568708006310 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 568708006311 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 568708006312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568708006313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708006314 dimer interface [polypeptide binding]; other site 568708006315 phosphorylation site [posttranslational modification] 568708006316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708006317 ATP binding site [chemical binding]; other site 568708006318 Mg2+ binding site [ion binding]; other site 568708006319 G-X-G motif; other site 568708006320 Signal peptide predicted for STM_MW13911 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 24 and 25 568708006321 2 probable transmembrane helices predicted for STM_MW13911 by TMHMM2.0 at aa 9-31 and 305-327 568708006324 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 568708006325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708006326 active site 568708006327 phosphorylation site [posttranslational modification] 568708006328 intermolecular recognition site; other site 568708006329 dimerization interface [polypeptide binding]; other site 568708006330 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708006331 DNA binding residues [nucleotide binding] 568708006332 dimerization interface [polypeptide binding]; other site 568708006335 hypothetical protein; Provisional; Region: PRK10292 568708006337 Uncharacterized conserved protein [Function unknown]; Region: COG1683 568708006338 Uncharacterized conserved protein [Function unknown]; Region: COG3272 568708006339 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 568708006342 transcriptional regulator MirA; Provisional; Region: PRK15043 568708006343 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 568708006344 DNA binding residues [nucleotide binding] 568708006346 two component system sensor kinase SsrB; Provisional; Region: PRK15369 568708006347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708006348 active site 568708006349 phosphorylation site [posttranslational modification] 568708006350 intermolecular recognition site; other site 568708006351 dimerization interface [polypeptide binding]; other site 568708006352 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708006353 DNA binding residues [nucleotide binding] 568708006354 dimerization interface [polypeptide binding]; other site 568708006357 two component system sensor kinase SsrA; Provisional; Region: PRK15347 568708006358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708006359 dimerization interface [polypeptide binding]; other site 568708006360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708006361 dimer interface [polypeptide binding]; other site 568708006362 phosphorylation site [posttranslational modification] 568708006363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708006364 ATP binding site [chemical binding]; other site 568708006365 Mg2+ binding site [ion binding]; other site 568708006366 G-X-G motif; other site 568708006367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708006368 active site 568708006369 phosphorylation site [posttranslational modification] 568708006370 intermolecular recognition site; other site 568708006371 dimerization interface [polypeptide binding]; other site 568708006376 1 probable transmembrane helix predicted for STM_MW13971 by TMHMM2.0 at aa 20-42 568708006377 Signal peptide predicted for STM_MW13971 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.442 between residues 36 and 37 568708006378 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 568708006379 outer membrane secretin SsaC; Provisional; Region: PRK15346 568708006380 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 568708006381 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 568708006384 type III secretion system protein SsaD; Provisional; Region: PRK15367 568708006385 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 568708006386 1 probable transmembrane helix predicted for STM_MW14001 by TMHMM2.0 at aa 117-139 568708006387 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 568708006389 type III secretion system chaperone SseA; Provisional; Region: PRK15365 568708006390 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 568708006392 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 568708006394 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 568708006396 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 568708006397 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 568708006399 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 568708006400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568708006401 TPR motif; other site 568708006402 binding surface 568708006404 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 568708006405 2 probable transmembrane helices predicted for STM_MW14091 by TMHMM2.0 at aa 64-86 and 90-112 568708006406 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 568708006407 2 probable transmembrane helices predicted for STM_MW14101 by TMHMM2.0 at aa 65-87 and 97-116 568708006408 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 568708006410 type III secretion system protein SsaH; Provisional; Region: PRK15356 568708006412 type III secretion system protein SsaI; Provisional; Region: PRK15355 568708006414 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 568708006415 Signal peptide predicted for STM_MW14141 by SignalP 2.0 HMM (Signal peptide probability 0.756) with cleavage site probability 0.748 between residues 18 and 19 568708006417 1 probable transmembrane helix predicted for STM_MW14141 by TMHMM2.0 at aa 223-245 568708006418 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 568708006419 type III secretion system protein SsaK; Provisional; Region: PRK15354 568708006420 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 568708006421 type III secretion system protein SsaL; Provisional; Region: PRK15345 568708006422 HrpJ-like domain; Region: HrpJ; pfam07201 568708006423 TyeA; Region: TyeA; cl07611 568708006425 type III secretion system protein SsaM; Provisional; Region: PRK15353 568708006426 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 568708006427 FHIPEP family; Region: FHIPEP; pfam00771 568708006428 6 probable transmembrane helices predicted for STM_MW14191 by TMHMM2.0 at aa 24-41, 48-67, 115-137, 206-228, 248-270 and 291-313 568708006430 type III secretion system ATPase SsaN; Validated; Region: PRK07594 568708006431 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 568708006432 Walker A motif; other site 568708006433 ATP binding site [chemical binding]; other site 568708006434 Walker B motif; other site 568708006436 type III secretion system protein SsaO; Provisional; Region: PRK15352 568708006437 type III secretion system protein SsaP; Provisional; Region: PRK15351 568708006438 type III secretion system protein SsaQ; Validated; Region: PRK08035 568708006439 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 568708006440 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 568708006442 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 568708006443 4 probable transmembrane helices predicted for STM_MW14241 by TMHMM2.0 at aa 10-31, 52-74, 154-176 and 189-211 568708006445 type III secretion system protein SsaS; Provisional; Region: PRK15350 568708006447 2 probable transmembrane helices predicted for STM_MW14251 by TMHMM2.0 at aa 13-35 and 55-77 568708006448 type III secretion system protein SsaT; Provisional; Region: PRK15349 568708006450 6 probable transmembrane helices predicted for STM_MW14261 by TMHMM2.0 at aa 7-29, 34-56, 68-90, 129-151, 183-205 and 215-237 568708006451 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 568708006452 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 568708006454 4 probable transmembrane helices predicted for STM_MW14271 by TMHMM2.0 at aa 21-43, 86-108, 146-168 and 178-200 568708006455 multidrug efflux protein; Reviewed; Region: PRK01766 568708006456 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 568708006457 cation binding site [ion binding]; other site 568708006459 12 probable transmembrane helices predicted for STM_MW14281 by TMHMM2.0 at aa 12-34, 44-66, 91-113, 128-147, 160-180, 190-212, 241-263, 278-300, 313-335, 350-367, 387-409 and 419-438 568708006460 Signal peptide predicted for STM_MW14281 by SignalP 2.0 HMM (Signal peptide probability 0.836) with cleavage site probability 0.480 between residues 26 and 27 568708006461 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 568708006462 Lumazine binding domain; Region: Lum_binding; pfam00677 568708006463 Lumazine binding domain; Region: Lum_binding; pfam00677 568708006465 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 568708006466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708006467 S-adenosylmethionine binding site [chemical binding]; other site 568708006469 putative transporter; Provisional; Region: PRK11043 568708006470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708006471 putative substrate translocation pore; other site 568708006473 11 probable transmembrane helices predicted for STM_MW14311 by TMHMM2.0 at aa 7-29, 39-61, 73-92, 97-119, 132-154, 159-178, 208-230, 235-257, 270-292, 296-318 and 339-361 568708006474 Signal peptide predicted for STM_MW14311 by SignalP 2.0 HMM (Signal peptide probability 0.933) with cleavage site probability 0.917 between residues 30 and 31 568708006475 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 568708006476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708006477 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568708006478 dimerization interface [polypeptide binding]; other site 568708006481 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 568708006482 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708006483 DNA binding site [nucleotide binding] 568708006484 domain linker motif; other site 568708006485 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 568708006486 dimerization interface [polypeptide binding]; other site 568708006487 ligand binding site [chemical binding]; other site 568708006490 superoxide dismutase; Provisional; Region: PRK10543 568708006491 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 568708006492 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 568708006495 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 568708006496 NlpC/P60 family; Region: NLPC_P60; pfam00877 568708006498 Signal peptide predicted for STM_MW14351 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.814 between residues 38 and 39 568708006499 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 568708006500 putative GSH binding site [chemical binding]; other site 568708006501 catalytic residues [active] 568708006503 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 568708006504 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 568708006505 dimer interface [polypeptide binding]; other site 568708006506 catalytic site [active] 568708006507 putative active site [active] 568708006508 putative substrate binding site [chemical binding]; other site 568708006510 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568708006511 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 568708006512 dimer interface [polypeptide binding]; other site 568708006513 active site 568708006514 metal binding site [ion binding]; metal-binding site 568708006515 glutathione binding site [chemical binding]; other site 568708006517 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568708006518 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 568708006519 FMN binding site [chemical binding]; other site 568708006520 active site 568708006521 substrate binding site [chemical binding]; other site 568708006522 catalytic residue [active] 568708006524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568708006525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708006527 Predicted Fe-S protein [General function prediction only]; Region: COG3313 568708006529 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568708006530 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568708006531 active site 568708006532 catalytic tetrad [active] 568708006534 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 568708006535 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 568708006536 E-class dimer interface [polypeptide binding]; other site 568708006537 P-class dimer interface [polypeptide binding]; other site 568708006538 active site 568708006539 Cu2+ binding site [ion binding]; other site 568708006540 Zn2+ binding site [ion binding]; other site 568708006541 Signal peptide predicted for STM_MW14431 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.974 between residues 19 and 20 568708006543 Fusaric acid resistance protein family; Region: FUSC; pfam04632 568708006544 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 568708006546 12 probable transmembrane helices predicted for STM_MW14441 by TMHMM2.0 at aa 23-41, 46-65, 72-90, 94-113, 120-142, 157-179, 362-381, 385-404, 411-433, 438-455, 462-481 and 496-515 568708006547 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 568708006548 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568708006549 HlyD family secretion protein; Region: HlyD_3; pfam13437 568708006551 1 probable transmembrane helix predicted for STM_MW14451 by TMHMM2.0 at aa 20-42 568708006552 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 568708006553 2 probable transmembrane helices predicted for STM_MW14461 by TMHMM2.0 at aa 18-40 and 53-75 568708006555 transcriptional regulator SlyA; Provisional; Region: PRK03573 568708006556 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 568708006558 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 568708006559 Signal peptide predicted for STM_MW14481 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.725 between residues 21 and 22 568708006560 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 568708006562 lysozyme inhibitor; Provisional; Region: PRK11372 568708006563 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 568708006564 Signal peptide predicted for STM_MW14501 by SignalP 2.0 HMM (Signal peptide probability 0.703) with cleavage site probability 0.553 between residues 22 and 23 568708006566 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 568708006567 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 568708006568 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 568708006571 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 568708006572 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 568708006573 active site 568708006574 HIGH motif; other site 568708006575 dimer interface [polypeptide binding]; other site 568708006576 KMSKS motif; other site 568708006577 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568708006578 RNA binding surface [nucleotide binding]; other site 568708006581 pyridoxamine kinase; Validated; Region: PRK05756 568708006582 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 568708006583 dimer interface [polypeptide binding]; other site 568708006584 pyridoxal binding site [chemical binding]; other site 568708006585 ATP binding site [chemical binding]; other site 568708006587 glutathionine S-transferase; Provisional; Region: PRK10542 568708006588 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 568708006589 C-terminal domain interface [polypeptide binding]; other site 568708006590 GSH binding site (G-site) [chemical binding]; other site 568708006591 dimer interface [polypeptide binding]; other site 568708006592 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 568708006593 dimer interface [polypeptide binding]; other site 568708006594 N-terminal domain interface [polypeptide binding]; other site 568708006595 substrate binding pocket (H-site) [chemical binding]; other site 568708006598 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 568708006599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708006600 putative substrate translocation pore; other site 568708006601 POT family; Region: PTR2; pfam00854 568708006602 14 probable transmembrane helices predicted for STM_MW14551 by TMHMM2.0 at aa 22-44, 59-81, 90-107, 112-129, 150-172, 177-199, 220-239, 244-261, 274-296, 323-340, 353-371, 386-408, 415-437 and 457-479 568708006604 endonuclease III; Provisional; Region: PRK10702 568708006605 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568708006606 minor groove reading motif; other site 568708006607 helix-hairpin-helix signature motif; other site 568708006608 substrate binding pocket [chemical binding]; other site 568708006609 active site 568708006610 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 568708006614 electron transport complex RsxE subunit; Provisional; Region: PRK12405 568708006616 5 probable transmembrane helices predicted for STM_MW14571 by TMHMM2.0 at aa 34-56, 69-87, 91-113, 126-148 and 183-205 568708006617 electron transport complex protein RnfG; Validated; Region: PRK01908 568708006619 Signal peptide predicted for STM_MW14581 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.958 between residues 24 and 25 568708006620 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 568708006622 10 probable transmembrane helices predicted for STM_MW14591 by TMHMM2.0 at aa 20-39, 43-62, 69-91, 95-117, 124-146, 214-236, 243-262, 272-294, 301-318 and 323-342 568708006623 Signal peptide predicted for STM_MW14591 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.568 between residues 33 and 34 568708006624 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 568708006625 SLBB domain; Region: SLBB; pfam10531 568708006626 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 568708006629 electron transport complex protein RnfB; Provisional; Region: PRK05113 568708006630 Putative Fe-S cluster; Region: FeS; cl17515 568708006631 4Fe-4S binding domain; Region: Fer4; pfam00037 568708006634 Signal peptide predicted for STM_MW14611 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.876 between residues 30 and 31 568708006635 1 probable transmembrane helix predicted for STM_MW14611 by TMHMM2.0 at aa 4-26 568708006636 electron transport complex protein RsxA; Provisional; Region: PRK05151 568708006638 6 probable transmembrane helices predicted for STM_MW14621 by TMHMM2.0 at aa 5-27, 42-64, 69-88, 103-125, 132-154 and 169-191 568708006639 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 568708006641 4 probable transmembrane helices predicted for STM_MW14631 by TMHMM2.0 at aa 13-35, 55-77, 90-109 and 114-133 568708006642 Signal peptide predicted for STM_MW14631 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.785 between residues 39 and 40 568708006643 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 568708006645 putative oxidoreductase; Provisional; Region: PRK11579 568708006646 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568708006647 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568708006650 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 568708006651 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 568708006652 active site 568708006653 purine riboside binding site [chemical binding]; other site 568708006655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 568708006656 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 568708006658 Signal peptide predicted for STM_MW14671 by SignalP 2.0 HMM (Signal peptide probability 0.945) with cleavage site probability 0.863 between residues 19 and 20 568708006659 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 568708006660 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 568708006661 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 568708006663 fumarate hydratase; Provisional; Region: PRK15389 568708006664 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 568708006665 Fumarase C-terminus; Region: Fumerase_C; pfam05683 568708006668 fumarate hydratase; Reviewed; Region: fumC; PRK00485 568708006669 Class II fumarases; Region: Fumarase_classII; cd01362 568708006670 active site 568708006671 tetramer interface [polypeptide binding]; other site 568708006674 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 568708006676 sensor protein RstB; Provisional; Region: PRK10604 568708006677 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708006678 dimerization interface [polypeptide binding]; other site 568708006679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708006680 dimer interface [polypeptide binding]; other site 568708006681 phosphorylation site [posttranslational modification] 568708006682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708006683 ATP binding site [chemical binding]; other site 568708006684 Mg2+ binding site [ion binding]; other site 568708006685 G-X-G motif; other site 568708006687 2 probable transmembrane helices predicted for STM_MW14721 by TMHMM2.0 at aa 5-27 and 139-156 568708006689 Signal peptide predicted for STM_MW14721 by SignalP 2.0 HMM (Signal peptide probability 0.881) with cleavage site probability 0.715 between residues 28 and 29 568708006690 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 568708006691 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 568708006692 active site 568708006694 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568708006695 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 568708006696 trimer interface [polypeptide binding]; other site 568708006697 eyelet of channel; other site 568708006699 1 probable transmembrane helix predicted for STM_MW14741 by TMHMM2.0 at aa 5-22 568708006700 Signal peptide predicted for STM_MW14741 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 568708006701 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 568708006702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708006703 active site 568708006704 phosphorylation site [posttranslational modification] 568708006705 intermolecular recognition site; other site 568708006706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708006707 DNA binding site [nucleotide binding] 568708006710 GlpM protein; Region: GlpM; pfam06942 568708006711 4 probable transmembrane helices predicted for STM_MW14761 by TMHMM2.0 at aa 2-21, 25-47, 59-81 and 86-108 568708006713 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 568708006714 Spore germination protein; Region: Spore_permease; cl17796 568708006715 13 probable transmembrane helices predicted for STM_MW14771 by TMHMM2.0 at aa 5-27, 37-59, 90-112, 127-149, 156-178, 205-222, 235-257, 277-299, 332-351, 356-378, 385-403, 408-427 and 440-459 568708006717 Signal peptide predicted for STM_MW14771 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.401 between residues 31 and 32 568708006718 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 568708006719 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 568708006720 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 568708006722 Signal peptide predicted for STM_MW14781 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23 568708006723 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 568708006724 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 568708006725 ligand binding site [chemical binding]; other site 568708006726 homodimer interface [polypeptide binding]; other site 568708006727 NAD(P) binding site [chemical binding]; other site 568708006728 trimer interface B [polypeptide binding]; other site 568708006729 trimer interface A [polypeptide binding]; other site 568708006730 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 568708006733 5 probable transmembrane helices predicted for STM_MW14791 by TMHMM2.0 at aa 169-191, 402-419, 423-445, 452-471 and 476-498 568708006734 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 568708006735 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 568708006736 9 probable transmembrane helices predicted for STM_MW14801 by TMHMM2.0 at aa 5-24, 33-50, 55-72, 85-107, 122-144, 164-181, 185-207, 214-236 and 240-259 568708006738 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 568708006739 Domain of unknown function DUF20; Region: UPF0118; pfam01594 568708006741 8 probable transmembrane helices predicted for STM_MW14811 by TMHMM2.0 at aa 5-24, 29-51, 63-85, 144-166, 196-218, 222-244, 257-279 and 299-321 568708006742 Signal peptide predicted for STM_MW14811 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 30 and 31 568708006743 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 568708006744 4 probable transmembrane helices predicted for STM_MW14821 by TMHMM2.0 at aa 2-19, 29-51, 56-78 and 82-101 568708006746 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 568708006748 4 probable transmembrane helices predicted for STM_MW14831 by TMHMM2.0 at aa 10-29, 36-53, 63-85 and 92-106 568708006749 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 568708006751 Signal peptide predicted for STM_MW14841 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.625 between residues 19 and 20 568708006753 1 probable transmembrane helix predicted for STM_MW14851 by TMHMM2.0 at aa 16-38 568708006754 Signal peptide predicted for STM_MW14851 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 33 and 34 568708006755 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 568708006756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708006757 putative substrate translocation pore; other site 568708006758 12 probable transmembrane helices predicted for STM_MW14861 by TMHMM2.0 at aa 37-59, 74-95, 102-124, 128-150, 157-179, 189-211, 240-262, 272-291, 304-323, 328-350, 363-385 and 389-411 568708006760 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 568708006761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708006762 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 568708006763 dimerization interface [polypeptide binding]; other site 568708006764 substrate binding pocket [chemical binding]; other site 568708006767 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 568708006768 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568708006769 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568708006771 putative dithiobiotin synthetase; Provisional; Region: PRK12374 568708006772 AAA domain; Region: AAA_26; pfam13500 568708006774 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 568708006775 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 568708006776 Cl- selectivity filter; other site 568708006777 Cl- binding residues [ion binding]; other site 568708006778 pore gating glutamate residue; other site 568708006779 dimer interface [polypeptide binding]; other site 568708006780 10 probable transmembrane helices predicted for STM_MW14901 by TMHMM2.0 at aa 12-34, 66-83, 158-180, 185-207, 234-256, 271-293, 300-322, 332-354, 361-383 and 398-416 568708006782 Signal peptide predicted for STM_MW14901 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.860 between residues 37 and 38 568708006783 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 568708006784 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 568708006785 Walker A/P-loop; other site 568708006786 ATP binding site [chemical binding]; other site 568708006787 Q-loop/lid; other site 568708006788 ABC transporter signature motif; other site 568708006789 Walker B; other site 568708006790 D-loop; other site 568708006791 H-loop/switch region; other site 568708006792 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 568708006795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708006796 dimer interface [polypeptide binding]; other site 568708006797 conserved gate region; other site 568708006798 ABC-ATPase subunit interface; other site 568708006799 5 probable transmembrane helices predicted for STM_MW14921 by TMHMM2.0 at aa 22-44, 51-73, 78-100, 149-171 and 181-203 568708006801 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 568708006803 Signal peptide predicted for STM_MW14931 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 568708006804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708006805 dimer interface [polypeptide binding]; other site 568708006806 conserved gate region; other site 568708006807 putative PBP binding loops; other site 568708006808 ABC-ATPase subunit interface; other site 568708006809 6 probable transmembrane helices predicted for STM_MW14941 by TMHMM2.0 at aa 9-31, 46-68, 89-111, 126-145, 173-195 and 205-227 568708006811 Signal peptide predicted for STM_MW14941 by SignalP 2.0 HMM (Signal peptide probability 0.819) with cleavage site probability 0.629 between residues 26 and 27 568708006812 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 568708006814 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 568708006816 8 probable transmembrane helices predicted for STM_MW14961 by TMHMM2.0 at aa 10-32, 44-66, 88-107, 114-136, 151-173, 180-202, 222-244 and 251-273 568708006817 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 568708006818 4Fe-4S binding domain; Region: Fer4; pfam00037 568708006820 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 568708006821 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 568708006822 putative [Fe4-S4] binding site [ion binding]; other site 568708006823 putative molybdopterin cofactor binding site [chemical binding]; other site 568708006824 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 568708006825 putative molybdopterin cofactor binding site; other site 568708006829 Signal peptide predicted for STM_MW14981 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 45 and 46 568708006830 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 568708006831 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 568708006832 putative [Fe4-S4] binding site [ion binding]; other site 568708006833 putative molybdopterin cofactor binding site [chemical binding]; other site 568708006834 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 568708006835 putative molybdopterin cofactor binding site; other site 568708006839 Signal peptide predicted for STM_MW14991 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.843 between residues 43 and 44 568708006840 1 probable transmembrane helix predicted for STM_MW14991 by TMHMM2.0 at aa 21-43 568708006841 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 568708006843 Signal peptide predicted for STM_MW15001 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23 568708006844 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 568708006845 Signal peptide predicted for STM_MW15011 by SignalP 2.0 HMM (Signal peptide probability 0.756) with cleavage site probability 0.676 between residues 19 and 20 568708006847 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 568708006848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708006849 Coenzyme A binding pocket [chemical binding]; other site 568708006850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568708006852 hypothetical protein; Provisional; Region: PRK13659 568708006854 Signal peptide predicted for STM_MW15031 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 28 and 29 568708006855 hypothetical protein; Provisional; Region: PRK02237 568708006857 4 probable transmembrane helices predicted for STM_MW15041 by TMHMM2.0 at aa 7-26, 30-52, 59-78 and 83-105 568708006858 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 568708006859 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 568708006860 putative active site pocket [active] 568708006861 putative metal binding site [ion binding]; other site 568708006864 putative oxidoreductase; Provisional; Region: PRK10083 568708006865 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 568708006866 putative NAD(P) binding site [chemical binding]; other site 568708006867 catalytic Zn binding site [ion binding]; other site 568708006868 structural Zn binding site [ion binding]; other site 568708006872 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 568708006873 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 568708006874 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 568708006877 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 568708006878 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568708006879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708006880 DNA-binding site [nucleotide binding]; DNA binding site 568708006881 FCD domain; Region: FCD; pfam07729 568708006884 malonic semialdehyde reductase; Provisional; Region: PRK10538 568708006885 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 568708006886 putative NAD(P) binding site [chemical binding]; other site 568708006887 homodimer interface [polypeptide binding]; other site 568708006888 homotetramer interface [polypeptide binding]; other site 568708006889 active site 568708006891 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 568708006892 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 568708006893 active site 568708006894 Zn binding site [ion binding]; other site 568708006896 General stress protein [General function prediction only]; Region: GsiB; COG3729 568708006898 hypothetical protein; Validated; Region: PRK03657 568708006900 hypothetical protein; Provisional; Region: PRK10053 568708006901 Signal peptide predicted for STM_MW15151 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 568708006903 pfam_scan;Pfam:PF07690; E()=1.1E-27;score=97.0;query13-337;description=MFS_1; tmhmm; query 1-391 568708006905 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 568708006906 EamA-like transporter family; Region: EamA; pfam00892 568708006907 10 probable transmembrane helices predicted for STM_MW15171 by TMHMM2.0 at aa 7-24, 34-52, 59-81, 91-110, 117-136, 140-162, 174-196, 216-238, 245-264 and 268-290 568708006909 MarB protein; Region: MarB; pfam13999 568708006910 Signal peptide predicted for STM_MW15181 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.994 between residues 21 and 22 568708006911 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 568708006912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708006914 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 568708006915 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568708006917 inner membrane protein; Provisional; Region: PRK10995 568708006919 6 probable transmembrane helices predicted for STM_MW15211 by TMHMM2.0 at aa 10-32, 44-66, 71-93, 117-139, 154-176 and 196-217 568708006920 putative arabinose transporter; Provisional; Region: PRK03545 568708006921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708006922 putative substrate translocation pore; other site 568708006923 12 probable transmembrane helices predicted for STM_MW15221 by TMHMM2.0 at aa 12-34, 49-71, 80-99, 109-131, 138-160, 170-189, 210-229, 244-266, 273-292, 302-324, 331-350 and 360-382 568708006925 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708006926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708006927 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 568708006928 putative dimerization interface [polypeptide binding]; other site 568708006931 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 568708006932 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 568708006933 NAD(P) binding site [chemical binding]; other site 568708006934 catalytic residues [active] 568708006936 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 568708006937 glutaminase; Provisional; Region: PRK00971 568708006939 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 568708006940 Predicted membrane protein [Function unknown]; Region: COG3781 568708006942 3 probable transmembrane helices predicted for STM_MW15271 by TMHMM2.0 at aa 39-58, 63-81 and 229-251 568708006943 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 568708006945 Signal peptide predicted for STM_MW15281 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 29 and 30 568708006946 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 568708006947 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568708006948 eyelet of channel; other site 568708006949 trimer interface [polypeptide binding]; other site 568708006951 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 568708006952 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 568708006954 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 568708006955 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 568708006956 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 568708006957 Rubredoxin [Energy production and conversion]; Region: COG1773 568708006958 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 568708006959 iron binding site [ion binding]; other site 568708006962 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 568708006964 HupF/HypC family; Region: HupF_HypC; cl00394 568708006966 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 568708006967 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 568708006968 putative substrate-binding site; other site 568708006969 nickel binding site [ion binding]; other site 568708006971 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 568708006972 4 probable transmembrane helices predicted for STM_MW15361 by TMHMM2.0 at aa 43-62, 82-104, 151-173 and 203-225 568708006974 hydrogenase 1 large subunit; Provisional; Region: PRK10170 568708006975 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 568708006977 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 568708006978 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 568708006980 Signal peptide predicted for STM_MW15381 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.965 between residues 45 and 46 568708006981 1 probable transmembrane helix predicted for STM_MW15381 by TMHMM2.0 at aa 21-43 568708006982 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 568708006983 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 568708006984 active site 568708006985 Signal peptide predicted for STM_MW15391 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.793 between residues 24 and 25 568708006987 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568708006988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708006989 DNA-binding site [nucleotide binding]; DNA binding site 568708006990 FCD domain; Region: FCD; pfam07729 568708006993 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 568708006994 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 568708006995 putative NAD(P) binding site [chemical binding]; other site 568708006996 catalytic Zn binding site [ion binding]; other site 568708006997 structural Zn binding site [ion binding]; other site 568708007000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708007001 D-galactonate transporter; Region: 2A0114; TIGR00893 568708007002 putative substrate translocation pore; other site 568708007004 12 probable transmembrane helices predicted for STM_MW15421 by TMHMM2.0 at aa 7-26, 46-68, 75-97, 101-123, 135-157, 162-184, 228-250, 265-287, 303-325, 329-350, 362-384 and 394-413 568708007005 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 568708007007 1 probable transmembrane helix predicted for STM_MW15431 by TMHMM2.0 at aa 26-45 568708007008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708007009 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568708007010 putative substrate translocation pore; other site 568708007011 11 probable transmembrane helices predicted for STM_MW15441 by TMHMM2.0 at aa 25-47, 57-79, 86-105, 110-132, 144-166, 171-193, 219-241, 261-283, 295-329, 349-371 and 378-400 568708007013 hypothetical protein; Provisional; Region: PRK06184 568708007014 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568708007015 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568708007017 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568708007018 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568708007019 putative DNA binding site [nucleotide binding]; other site 568708007020 putative Zn2+ binding site [ion binding]; other site 568708007025 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568708007026 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708007027 DNA binding site [nucleotide binding] 568708007028 domain linker motif; other site 568708007029 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 568708007030 dimerization interface (closed form) [polypeptide binding]; other site 568708007031 ligand binding site [chemical binding]; other site 568708007034 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 568708007035 Signal peptide predicted for STM_MW15511 by SignalP 2.0 HMM (Signal peptide probability 0.663) with cleavage site probability 0.221 between residues 27 and 28 568708007036 10 probable transmembrane helices predicted for STM_MW15511 by TMHMM2.0 at aa 13-35, 77-99, 112-134, 139-161, 195-217, 237-256, 263-285, 328-350, 357-379 and 444-466 568708007038 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 568708007039 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568708007040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708007041 homodimer interface [polypeptide binding]; other site 568708007042 catalytic residue [active] 568708007044 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 568708007045 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 568708007046 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 568708007047 active site 568708007048 catalytic site [active] 568708007051 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 568708007052 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 568708007053 active site 568708007054 catalytic site [active] 568708007056 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 568708007057 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 568708007058 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 568708007059 catalytic site [active] 568708007060 active site 568708007061 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 568708007063 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 568708007065 Signal peptide predicted for STM_MW15561 by SignalP 2.0 HMM (Signal peptide probability 0.842) with cleavage site probability 0.371 between residues 19 and 20 568708007066 acid-resistance protein; Provisional; Region: hdeB; PRK11566 568708007067 1 probable transmembrane helix predicted for STM_MW15571 by TMHMM2.0 at aa 4-26 568708007068 Signal peptide predicted for STM_MW15571 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 24 and 25 568708007069 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 568708007071 biofilm-dependent modulation protein; Provisional; Region: PRK11436 568708007073 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 568708007075 malate dehydrogenase; Provisional; Region: PRK13529 568708007076 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568708007077 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 568708007078 NAD(P) binding site [chemical binding]; other site 568708007081 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 568708007082 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 568708007083 NAD binding site [chemical binding]; other site 568708007084 substrate binding site [chemical binding]; other site 568708007085 catalytic Zn binding site [ion binding]; other site 568708007086 tetramer interface [polypeptide binding]; other site 568708007087 structural Zn binding site [ion binding]; other site 568708007090 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 568708007091 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 568708007093 4 probable transmembrane helices predicted for STM_MW15631 by TMHMM2.0 at aa 13-35, 50-72, 112-134 and 149-171 568708007094 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 568708007095 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 568708007098 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 568708007099 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 568708007100 [4Fe-4S] binding site [ion binding]; other site 568708007101 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568708007102 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 568708007103 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 568708007104 molybdopterin cofactor binding site; other site 568708007108 Signal peptide predicted for STM_MW15651 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.781 between residues 33 and 34 568708007109 aromatic amino acid exporter; Provisional; Region: PRK11689 568708007111 9 probable transmembrane helices predicted for STM_MW15661 by TMHMM2.0 at aa 15-34, 46-68, 72-94, 101-119, 129-151, 163-185, 190-212, 219-241 and 251-270 568708007112 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568708007113 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 568708007114 trimer interface [polypeptide binding]; other site 568708007115 eyelet of channel; other site 568708007116 Signal peptide predicted for STM_MW15671 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 568708007118 Uncharacterized conserved protein [Function unknown]; Region: COG3791 568708007120 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 568708007121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708007122 putative substrate translocation pore; other site 568708007123 14 probable transmembrane helices predicted for STM_MW15691 by TMHMM2.0 at aa 7-29, 44-66, 73-92, 97-119, 132-154, 158-180, 193-212, 222-240, 261-283, 298-320, 322-344, 354-376, 389-411 and 468-490 568708007125 TetR family transcriptional regulator; Provisional; Region: PRK14996 568708007126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708007128 1 probable transmembrane helix predicted for STM_MW15701 by TMHMM2.0 at aa 151-170 568708007129 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 568708007130 Signal peptide predicted for STM_MW15711 by SignalP 2.0 HMM (Signal peptide probability 0.611) with cleavage site probability 0.599 between residues 57 and 58 568708007131 12 probable transmembrane helices predicted for STM_MW15711 by TMHMM2.0 at aa 36-58, 73-95, 102-121, 131-153, 174-196, 211-233, 254-276, 286-308, 313-335, 345-367, 401-418 and 433-455 568708007133 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 568708007134 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 568708007135 [4Fe-4S] binding site [ion binding]; other site 568708007136 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568708007137 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568708007138 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568708007139 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 568708007140 molybdopterin cofactor binding site; other site 568708007143 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 568708007144 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 568708007146 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 568708007147 5 probable transmembrane helices predicted for STM_MW15751 by TMHMM2.0 at aa 5-27, 48-70, 90-112, 128-150 and 185-207 568708007149 hypothetical protein; Provisional; Region: PRK10281 568708007151 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 568708007153 L-asparagine permease; Provisional; Region: PRK15049 568708007155 12 probable transmembrane helices predicted for STM_MW15791 by TMHMM2.0 at aa 37-59, 64-86, 107-129, 144-166, 171-193, 218-240, 260-282, 302-324, 351-373, 377-399, 420-442 and 446-468 568708007156 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 568708007158 1 probable transmembrane helix predicted for STM_MW15801 by TMHMM2.0 at aa 4-26 568708007159 Signal peptide predicted for STM_MW15801 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.417 between residues 19 and 20 568708007160 Uncharacterized conserved protein [Function unknown]; Region: COG3391 568708007161 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 568708007162 Signal peptide predicted for STM_MW15811 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 30 and 31 568708007163 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 568708007164 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568708007165 N-terminal plug; other site 568708007166 ligand-binding site [chemical binding]; other site 568708007167 Signal peptide predicted for STM_MW15821 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.983 between residues 26 and 27 568708007170 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 568708007171 DNA-binding site [nucleotide binding]; DNA binding site 568708007172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 568708007173 FCD domain; Region: FCD; pfam07729 568708007176 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 568708007177 Prostaglandin dehydrogenases; Region: PGDH; cd05288 568708007178 NAD(P) binding site [chemical binding]; other site 568708007179 substrate binding site [chemical binding]; other site 568708007180 dimer interface [polypeptide binding]; other site 568708007182 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 568708007183 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568708007185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 568708007186 Signal peptide predicted for STM_MW15861 by SignalP 2.0 HMM (Signal peptide probability 0.633) with cleavage site probability 0.255 between residues 21 and 22 568708007187 5 probable transmembrane helices predicted for STM_MW15861 by TMHMM2.0 at aa 5-25, 32-54, 69-88, 95-117 and 122-144 568708007189 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 568708007191 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 568708007193 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 568708007195 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 568708007196 2 probable transmembrane helices predicted for STM_MW15911 by TMHMM2.0 at aa 33-55 and 62-84 568708007198 1-pyrroline dehydrogenase; Region: ABALDH; TIGR03374 568708007199 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 568708007200 tetrameric interface [polypeptide binding]; other site 568708007201 NAD binding site [chemical binding]; other site 568708007202 catalytic residues [active] 568708007203 substrate binding site [chemical binding]; other site 568708007205 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 568708007206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708007207 DNA-binding site [nucleotide binding]; DNA binding site 568708007208 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568708007209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708007210 homodimer interface [polypeptide binding]; other site 568708007211 catalytic residue [active] 568708007214 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 568708007216 Signal peptide predicted for STM_MW15941 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 20 and 21 568708007217 2 probable transmembrane helices predicted for STM_MW15961 by TMHMM2.0 at aa 33-67 and 82-104 568708007218 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 568708007220 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 568708007221 Signal peptide predicted for STM_MW15981 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708007223 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 568708007224 Peptidase family U32; Region: Peptidase_U32; pfam01136 568708007225 Collagenase; Region: DUF3656; pfam12392 568708007227 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568708007228 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708007229 non-specific DNA binding site [nucleotide binding]; other site 568708007230 salt bridge; other site 568708007231 sequence-specific DNA binding site [nucleotide binding]; other site 568708007232 Cupin domain; Region: Cupin_2; pfam07883 568708007235 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 568708007236 benzoate transporter; Region: benE; TIGR00843 568708007237 Signal peptide predicted for STM_MW16011 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.663 between residues 35 and 36 568708007239 11 probable transmembrane helices predicted for STM_MW16011 by TMHMM2.0 at aa 10-30, 43-65, 93-112, 119-138, 143-165, 172-194, 209-231, 252-274, 289-311, 318-340 and 360-382 568708007240 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 568708007242 Signal peptide predicted for STM_MW16021 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.785 between residues 24 and 25 568708007243 tellurite resistance protein TehB; Provisional; Region: PRK11207 568708007244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708007245 S-adenosylmethionine binding site [chemical binding]; other site 568708007247 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 568708007248 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 568708007249 gating phenylalanine in ion channel; other site 568708007251 10 probable transmembrane helices predicted for STM_MW16041 by TMHMM2.0 at aa 13-32, 47-69, 82-104, 108-130, 143-165, 169-188, 200-222, 237-254, 261-280 and 290-312 568708007252 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 568708007253 putative trimer interface [polypeptide binding]; other site 568708007254 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 568708007255 putative trimer interface [polypeptide binding]; other site 568708007256 putative CoA binding site [chemical binding]; other site 568708007257 putative CoA binding site [chemical binding]; other site 568708007258 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 568708007259 putative trimer interface [polypeptide binding]; other site 568708007260 putative CoA binding site [chemical binding]; other site 568708007261 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 568708007262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708007263 Coenzyme A binding pocket [chemical binding]; other site 568708007265 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 568708007266 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 568708007267 oligomer interface [polypeptide binding]; other site 568708007268 active site 568708007269 metal binding site [ion binding]; metal-binding site 568708007271 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 568708007272 active site 568708007273 P-loop; other site 568708007274 phosphorylation site [posttranslational modification] 568708007275 Signal peptide predicted for STM_MW16081 by SignalP 2.0 HMM (Signal peptide probability 0.832) with cleavage site probability 0.593 between residues 22 and 23 568708007277 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568708007278 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 568708007280 7 probable transmembrane helices predicted for STM_MW16091 by TMHMM2.0 at aa 35-57, 78-100, 169-188, 195-217, 251-273, 302-324 and 361-383 568708007281 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 568708007283 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568708007284 active site 568708007285 phosphorylation site [posttranslational modification] 568708007287 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 568708007288 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 568708007289 substrate binding site [chemical binding]; other site 568708007290 hexamer interface [polypeptide binding]; other site 568708007291 metal binding site [ion binding]; metal-binding site 568708007293 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568708007294 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 568708007295 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708007298 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 568708007299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708007300 Coenzyme A binding pocket [chemical binding]; other site 568708007302 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 568708007303 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 568708007304 teramer interface [polypeptide binding]; other site 568708007305 active site 568708007306 FMN binding site [chemical binding]; other site 568708007307 catalytic residues [active] 568708007309 Signal peptide predicted for STM_MW16151 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 24 and 25 568708007310 Uncharacterized conserved protein [Function unknown]; Region: COG2353 568708007312 Signal peptide predicted for STM_MW16161 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 23 and 24 568708007313 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 568708007314 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 568708007316 Signal peptide predicted for STM_MW16171 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 32 and 33 568708007317 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 568708007318 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 568708007319 substrate binding pocket [chemical binding]; other site 568708007320 catalytic triad [active] 568708007322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 568708007323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 568708007325 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 568708007326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708007327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568708007328 dimerization interface [polypeptide binding]; other site 568708007331 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 568708007332 dimer interface [polypeptide binding]; other site 568708007333 ligand binding site [chemical binding]; other site 568708007334 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 568708007335 HAMP domain; Region: HAMP; pfam00672 568708007336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568708007337 dimer interface [polypeptide binding]; other site 568708007338 putative CheW interface [polypeptide binding]; other site 568708007341 2 probable transmembrane helices predicted for STM_MW16211 by TMHMM2.0 at aa 26-48 and 203-225 568708007343 Signal peptide predicted for STM_MW16211 by SignalP 2.0 HMM (Signal peptide probability 0.742) with cleavage site probability 0.234 between residues 50 and 51 568708007344 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 568708007345 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 568708007346 substrate binding site [chemical binding]; other site 568708007347 catalytic Zn binding site [ion binding]; other site 568708007348 NAD binding site [chemical binding]; other site 568708007349 structural Zn binding site [ion binding]; other site 568708007350 dimer interface [polypeptide binding]; other site 568708007353 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 568708007354 putative metal binding site [ion binding]; other site 568708007355 putative homodimer interface [polypeptide binding]; other site 568708007356 putative homotetramer interface [polypeptide binding]; other site 568708007357 putative homodimer-homodimer interface [polypeptide binding]; other site 568708007358 putative allosteric switch controlling residues; other site 568708007360 5 probable transmembrane helices predicted for STM_MW16251 by TMHMM2.0 at aa 12-34, 54-76, 88-110, 114-136 and 155-177 568708007361 Sif protein; Region: Sif; cl11505 568708007362 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 568708007363 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 568708007364 active site 568708007365 catalytic triad [active] 568708007366 oxyanion hole [active] 568708007369 Predicted membrane protein [Function unknown]; Region: COG3326 568708007370 3 probable transmembrane helices predicted for STM_MW16271 by TMHMM2.0 at aa 2-21, 25-42 and 89-111 568708007372 Signal peptide predicted for STM_MW16271 by SignalP 2.0 HMM (Signal peptide probability 0.941) with cleavage site probability 0.622 between residues 26 and 27 568708007373 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568708007374 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568708007375 substrate binding pocket [chemical binding]; other site 568708007376 membrane-bound complex binding site; other site 568708007377 hinge residues; other site 568708007378 Signal peptide predicted for STM_MW16281 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708007380 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568708007381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708007382 dimer interface [polypeptide binding]; other site 568708007383 conserved gate region; other site 568708007384 putative PBP binding loops; other site 568708007385 ABC-ATPase subunit interface; other site 568708007386 4 probable transmembrane helices predicted for STM_MW16291 by TMHMM2.0 at aa 20-42, 55-74, 79-101 and 186-208 568708007388 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568708007389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708007390 Walker A/P-loop; other site 568708007391 ATP binding site [chemical binding]; other site 568708007392 Q-loop/lid; other site 568708007393 ABC transporter signature motif; other site 568708007394 Walker B; other site 568708007395 D-loop; other site 568708007396 H-loop/switch region; other site 568708007398 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568708007399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708007400 dimer interface [polypeptide binding]; other site 568708007401 conserved gate region; other site 568708007402 putative PBP binding loops; other site 568708007403 ABC-ATPase subunit interface; other site 568708007404 5 probable transmembrane helices predicted for STM_MW16311 by TMHMM2.0 at aa 30-49, 61-83, 93-115, 136-158 and 192-214 568708007406 contains an internal stop codon; tmhmm; query 1-516 568708007407 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 568708007408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708007409 S-adenosylmethionine binding site [chemical binding]; other site 568708007411 cytochrome b561; Provisional; Region: PRK11513 568708007413 4 probable transmembrane helices predicted for STM_MW16341 by TMHMM2.0 at aa 5-27, 40-62, 83-105 and 140-162 568708007414 Uncharacterized conserved protein [Function unknown]; Region: COG1434 568708007415 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568708007416 putative active site [active] 568708007418 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 568708007419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568708007420 ATP binding site [chemical binding]; other site 568708007421 putative Mg++ binding site [ion binding]; other site 568708007422 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708007423 nucleotide binding region [chemical binding]; other site 568708007424 ATP-binding site [chemical binding]; other site 568708007425 Helicase associated domain (HA2); Region: HA2; pfam04408 568708007426 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 568708007427 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 568708007432 azoreductase; Reviewed; Region: PRK00170 568708007433 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568708007435 Uncharacterized conserved protein [Function unknown]; Region: COG3791 568708007437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 568708007439 1 probable transmembrane helix predicted for STM_MW16391 by TMHMM2.0 at aa 5-24 568708007440 Signal peptide predicted for STM_MW16391 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 568708007441 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 568708007442 Signal peptide predicted for STM_MW16401 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.526 between residues 18 and 19 568708007443 hypothetical protein; Provisional; Region: PRK10695 568708007445 Signal peptide predicted for STM_MW16411 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.652 between residues 34 and 35 568708007446 1 probable transmembrane helix predicted for STM_MW16411 by TMHMM2.0 at aa 7-29 568708007447 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 568708007448 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 568708007449 putative ligand binding site [chemical binding]; other site 568708007450 putative NAD binding site [chemical binding]; other site 568708007451 catalytic site [active] 568708007454 heat-inducible protein; Provisional; Region: PRK10449 568708007455 Signal peptide predicted for STM_MW16431 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.429 between residues 20 and 21 568708007457 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 568708007458 Domain of unknown function (DUF333); Region: DUF333; pfam03891 568708007460 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 568708007461 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 568708007462 dimer interface [polypeptide binding]; other site 568708007463 PYR/PP interface [polypeptide binding]; other site 568708007464 TPP binding site [chemical binding]; other site 568708007465 substrate binding site [chemical binding]; other site 568708007466 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 568708007467 Domain of unknown function; Region: EKR; smart00890 568708007468 4Fe-4S binding domain; Region: Fer4_6; pfam12837 568708007469 4Fe-4S binding domain; Region: Fer4; pfam00037 568708007470 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 568708007471 TPP-binding site [chemical binding]; other site 568708007472 dimer interface [polypeptide binding]; other site 568708007477 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568708007478 Ligand Binding Site [chemical binding]; other site 568708007480 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 568708007482 4 probable transmembrane helices predicted for STM_MW16481 by TMHMM2.0 at aa 5-22, 32-51, 58-80 and 85-107 568708007485 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 568708007486 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 568708007487 Ligand Binding Site [chemical binding]; other site 568708007489 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 568708007490 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568708007491 ATP binding site [chemical binding]; other site 568708007492 Mg++ binding site [ion binding]; other site 568708007493 motif III; other site 568708007494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708007495 nucleotide binding region [chemical binding]; other site 568708007496 ATP-binding site [chemical binding]; other site 568708007497 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 568708007498 putative RNA binding site [nucleotide binding]; other site 568708007502 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 568708007503 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 568708007504 Cl binding site [ion binding]; other site 568708007505 oligomer interface [polypeptide binding]; other site 568708007506 2 probable transmembrane helices predicted for STM_MW16521 by TMHMM2.0 at aa 272-294 and 299-321 568708007508 HAMP domain; Region: HAMP; pfam00672 568708007509 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 568708007510 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568708007511 dimer interface [polypeptide binding]; other site 568708007512 putative CheW interface [polypeptide binding]; other site 568708007514 2 probable transmembrane helices predicted for STM_MW16531 by TMHMM2.0 at aa 7-29 and 33-55 568708007515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 568708007516 Smr domain; Region: Smr; pfam01713 568708007518 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 568708007519 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 568708007520 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 568708007521 DNA binding site [nucleotide binding] 568708007522 active site 568708007525 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 568708007526 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568708007527 ligand binding site [chemical binding]; other site 568708007528 flexible hinge region; other site 568708007529 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 568708007530 putative switch regulator; other site 568708007531 non-specific DNA interactions [nucleotide binding]; other site 568708007532 DNA binding site [nucleotide binding] 568708007533 sequence specific DNA binding site [nucleotide binding]; other site 568708007534 putative cAMP binding site [chemical binding]; other site 568708007537 universal stress protein UspE; Provisional; Region: PRK11175 568708007538 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568708007539 Ligand Binding Site [chemical binding]; other site 568708007540 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568708007541 Ligand Binding Site [chemical binding]; other site 568708007543 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 568708007545 2 probable transmembrane helices predicted for STM_MW16581 by TMHMM2.0 at aa 13-35 and 60-82 568708007546 Signal peptide predicted for STM_MW16581 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.822 between residues 32 and 33 568708007547 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 568708007548 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568708007549 5 probable transmembrane helices predicted for STM_MW16591 by TMHMM2.0 at aa 10-30, 39-61, 76-98, 117-134 and 138-160 568708007551 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 568708007552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708007553 non-specific DNA binding site [nucleotide binding]; other site 568708007554 salt bridge; other site 568708007555 sequence-specific DNA binding site [nucleotide binding]; other site 568708007556 Cupin domain; Region: Cupin_2; pfam07883 568708007559 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 568708007560 B3/4 domain; Region: B3_4; pfam03483 568708007562 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077 568708007564 1 probable transmembrane helix predicted for STM_MW16631 by TMHMM2.0 at aa 7-29 568708007565 Signal peptide predicted for STM_MW16631 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.639 between residues 24 and 25 568708007566 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 568708007567 Signal peptide predicted for STM_MW16651 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.535 between residues 21 and 22 568708007568 pfam_scan;Pfam:PF06445; E()=1.1E-16;score=60.6;query125- 282;description=AraC_E_bind; pfam_scan;Pfam:PF00165; E()=1.4E-10;score=40.5;query66-104;description=HTH_AraC 568708007571 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 568708007573 1 probable transmembrane helix predicted for STM_MW16681 by TMHMM2.0 at aa 12-34 568708007574 Signal peptide predicted for STM_MW16681 by SignalP 2.0 HMM (Signal peptide probability 0.933) with cleavage site probability 0.580 between residues 31 and 32 568708007575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568708007576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708007578 oxidoreductase; Provisional; Region: PRK12742 568708007579 classical (c) SDRs; Region: SDR_c; cd05233 568708007580 NAD(P) binding site [chemical binding]; other site 568708007581 active site 568708007583 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568708007584 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568708007585 active site 568708007586 catalytic tetrad [active] 568708007588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708007589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708007590 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 568708007591 putative effector binding pocket; other site 568708007592 putative dimerization interface [polypeptide binding]; other site 568708007595 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 568708007596 NmrA-like family; Region: NmrA; pfam05368 568708007597 NAD(P) binding site [chemical binding]; other site 568708007598 active site lysine 568708007599 1 probable transmembrane helix predicted for STM_MW16731 by TMHMM2.0 at aa 12-34 568708007601 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 568708007602 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568708007603 peptide binding site [polypeptide binding]; other site 568708007605 Signal peptide predicted for STM_MW16741 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.961 between residues 22 and 23 568708007606 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 568708007607 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 568708007608 putative active site [active] 568708007609 Zn binding site [ion binding]; other site 568708007611 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 568708007612 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 568708007613 active site 568708007616 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 568708007617 dimer interface [polypeptide binding]; other site 568708007618 catalytic triad [active] 568708007619 peroxidatic and resolving cysteines [active] 568708007621 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 568708007622 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 568708007623 putative aromatic amino acid binding site; other site 568708007624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708007625 Walker A motif; other site 568708007626 ATP binding site [chemical binding]; other site 568708007627 Walker B motif; other site 568708007628 arginine finger; other site 568708007630 hypothetical protein; Provisional; Region: PRK05415 568708007631 TIGR01620 family protein; Region: hyp_HI0043 568708007632 3 probable transmembrane helices predicted for STM_MW16791 by TMHMM2.0 at aa 70-89, 99-121 and 210-232 568708007634 Predicted ATPase [General function prediction only]; Region: COG3106 568708007636 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568708007637 active site residue [active] 568708007639 1 probable transmembrane helix predicted for STM_MW16811 by TMHMM2.0 at aa 5-24 568708007640 Signal peptide predicted for STM_MW16811 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 19 and 20 568708007641 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 568708007643 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 568708007644 phage shock protein C; Region: phageshock_pspC; TIGR02978 568708007646 1 probable transmembrane helix predicted for STM_MW16831 by TMHMM2.0 at aa 39-61 568708007647 phage shock protein B; Provisional; Region: pspB; PRK09458 568708007649 1 probable transmembrane helix predicted for STM_MW16841 by TMHMM2.0 at aa 4-26 568708007650 phage shock protein PspA; Provisional; Region: PRK10698 568708007652 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 568708007653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708007654 Walker A motif; other site 568708007655 ATP binding site [chemical binding]; other site 568708007656 Walker B motif; other site 568708007657 arginine finger; other site 568708007658 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 568708007661 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568708007662 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 568708007663 peptide binding site [polypeptide binding]; other site 568708007664 Signal peptide predicted for STM_MW16871 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 21 and 22 568708007666 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 568708007667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708007668 dimer interface [polypeptide binding]; other site 568708007669 conserved gate region; other site 568708007670 putative PBP binding loops; other site 568708007671 ABC-ATPase subunit interface; other site 568708007672 4 probable transmembrane helices predicted for STM_MW16881 by TMHMM2.0 at aa 23-45, 57-79, 194-216 and 229-251 568708007674 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 568708007675 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568708007676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708007677 dimer interface [polypeptide binding]; other site 568708007678 conserved gate region; other site 568708007679 putative PBP binding loops; other site 568708007680 ABC-ATPase subunit interface; other site 568708007681 6 probable transmembrane helices predicted for STM_MW16891 by TMHMM2.0 at aa 30-52, 99-121, 134-156, 198-217, 224-243 and 258-280 568708007683 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 568708007684 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568708007685 Walker A/P-loop; other site 568708007686 ATP binding site [chemical binding]; other site 568708007687 Q-loop/lid; other site 568708007688 ABC transporter signature motif; other site 568708007689 Walker B; other site 568708007690 D-loop; other site 568708007691 H-loop/switch region; other site 568708007692 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568708007695 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 568708007696 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568708007697 Walker A/P-loop; other site 568708007698 ATP binding site [chemical binding]; other site 568708007699 Q-loop/lid; other site 568708007700 ABC transporter signature motif; other site 568708007701 Walker B; other site 568708007702 D-loop; other site 568708007703 H-loop/switch region; other site 568708007705 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 568708007707 Protein kinase domain; Region: Pkinase; pfam00069 568708007708 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 568708007709 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 568708007710 NAD binding site [chemical binding]; other site 568708007711 homotetramer interface [polypeptide binding]; other site 568708007712 homodimer interface [polypeptide binding]; other site 568708007713 substrate binding site [chemical binding]; other site 568708007714 active site 568708007716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 568708007717 Uncharacterized conserved protein [Function unknown]; Region: COG2128 568708007718 exoribonuclease II; Provisional; Region: PRK05054 568708007719 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 568708007720 RNB domain; Region: RNB; pfam00773 568708007721 S1 RNA binding domain; Region: S1; pfam00575 568708007725 RNase II stability modulator; Provisional; Region: PRK10060 568708007726 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568708007727 putative active site [active] 568708007728 heme pocket [chemical binding]; other site 568708007729 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568708007730 metal binding site [ion binding]; metal-binding site 568708007731 active site 568708007732 I-site; other site 568708007733 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708007737 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568708007738 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568708007739 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708007742 translation initiation factor Sui1; Validated; Region: PRK06824 568708007743 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 568708007744 putative rRNA binding site [nucleotide binding]; other site 568708007746 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 568708007747 active site 568708007748 dimer interface [polypeptide binding]; other site 568708007750 Signal peptide predicted for STM_MW17021 by SignalP 2.0 HMM (Signal peptide probability 0.780) with cleavage site probability 0.772 between residues 20 and 21 568708007751 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 568708007752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 568708007753 TPR motif; other site 568708007754 binding surface 568708007755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568708007756 binding surface 568708007757 TPR motif; other site 568708007758 Predicted membrane protein [Function unknown]; Region: COG3771 568708007760 2 probable transmembrane helices predicted for STM_MW17041 by TMHMM2.0 at aa 5-23 and 43-65 568708007761 Signal peptide predicted for STM_MW17041 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.704 between residues 22 and 23 568708007762 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 568708007763 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 568708007764 active site 568708007765 6 probable transmembrane helices predicted for STM_MW17051 by TMHMM2.0 at aa 9-31, 51-68, 75-92, 157-179, 186-208 and 212-229 568708007767 Signal peptide predicted for STM_MW17051 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.977 between residues 24 and 25 568708007768 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 568708007769 dimerization interface [polypeptide binding]; other site 568708007770 active site 568708007772 aconitate hydratase; Validated; Region: PRK09277 568708007773 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 568708007774 substrate binding site [chemical binding]; other site 568708007775 ligand binding site [chemical binding]; other site 568708007776 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 568708007777 substrate binding site [chemical binding]; other site 568708007780 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 568708007781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708007782 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 568708007783 substrate binding site [chemical binding]; other site 568708007784 putative dimerization interface [polypeptide binding]; other site 568708007787 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 568708007788 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 568708007789 active site 568708007790 interdomain interaction site; other site 568708007791 putative metal-binding site [ion binding]; other site 568708007792 nucleotide binding site [chemical binding]; other site 568708007793 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 568708007794 domain I; other site 568708007795 DNA binding groove [nucleotide binding] 568708007796 phosphate binding site [ion binding]; other site 568708007797 domain II; other site 568708007798 domain III; other site 568708007799 nucleotide binding site [chemical binding]; other site 568708007800 catalytic site [active] 568708007801 domain IV; other site 568708007802 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 568708007803 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 568708007804 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 568708007805 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 568708007810 hypothetical protein; Provisional; Region: PRK11037 568708007812 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 568708007813 putative inner membrane peptidase; Provisional; Region: PRK11778 568708007814 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 568708007815 tandem repeat interface [polypeptide binding]; other site 568708007816 oligomer interface [polypeptide binding]; other site 568708007817 active site residues [active] 568708007819 2 probable transmembrane helices predicted for STM_MW17121 by TMHMM2.0 at aa 10-32 and 189-206 568708007821 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 568708007822 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 568708007823 NADP binding site [chemical binding]; other site 568708007824 homodimer interface [polypeptide binding]; other site 568708007825 active site 568708007827 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 568708007828 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 568708007829 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 568708007830 homodimer interface [polypeptide binding]; other site 568708007831 Walker A motif; other site 568708007832 ATP binding site [chemical binding]; other site 568708007833 hydroxycobalamin binding site [chemical binding]; other site 568708007834 Walker B motif; other site 568708007836 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 568708007837 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568708007838 RNA binding surface [nucleotide binding]; other site 568708007839 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 568708007840 probable active site [active] 568708007843 hypothetical protein; Provisional; Region: PRK11630 568708007845 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 568708007846 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 568708007847 active site 568708007848 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 568708007850 anthranilate synthase component I; Provisional; Region: PRK13564 568708007851 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 568708007852 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 568708007855 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 568708007856 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 568708007857 glutamine binding [chemical binding]; other site 568708007858 catalytic triad [active] 568708007859 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 568708007860 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 568708007864 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 568708007865 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 568708007866 active site 568708007867 ribulose/triose binding site [chemical binding]; other site 568708007868 phosphate binding site [ion binding]; other site 568708007869 substrate (anthranilate) binding pocket [chemical binding]; other site 568708007870 product (indole) binding pocket [chemical binding]; other site 568708007871 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 568708007872 active site 568708007875 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 568708007876 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 568708007877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708007878 catalytic residue [active] 568708007880 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 568708007881 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 568708007882 substrate binding site [chemical binding]; other site 568708007883 active site 568708007884 catalytic residues [active] 568708007885 heterodimer interface [polypeptide binding]; other site 568708007887 General stress protein [General function prediction only]; Region: GsiB; COG3729 568708007889 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 568708007890 dimerization interface [polypeptide binding]; other site 568708007891 metal binding site [ion binding]; metal-binding site 568708007893 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 568708007894 dinuclear metal binding motif [ion binding]; other site 568708007896 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 568708007897 dimanganese center [ion binding]; other site 568708007899 outer membrane protein W; Provisional; Region: PRK10959 568708007901 Signal peptide predicted for STM_MW17271 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 568708007902 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 568708007904 hypothetical protein; Provisional; Region: PRK02868 568708007905 Signal peptide predicted for STM_MW17291 by SignalP 2.0 HMM (Signal peptide probability 0.946) with cleavage site probability 0.435 between residues 38 and 39 568708007907 6 probable transmembrane helices predicted for STM_MW17291 by TMHMM2.0 at aa 20-42, 89-111, 118-140, 144-166, 187-209 and 219-241 568708007908 intracellular septation protein A; Reviewed; Region: PRK00259 568708007910 5 probable transmembrane helices predicted for STM_MW17301 by TMHMM2.0 at aa 20-42, 51-68, 78-95, 119-141 and 151-170 568708007911 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 568708007913 transport protein TonB; Provisional; Region: PRK10819 568708007914 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 568708007916 YciI-like protein; Reviewed; Region: PRK11370 568708007918 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 568708007919 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 568708007920 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 568708007921 putative active site [active] 568708007922 catalytic site [active] 568708007923 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 568708007924 putative active site [active] 568708007925 catalytic site [active] 568708007926 2 probable transmembrane helices predicted for STM_MW17341 by TMHMM2.0 at aa 10-29 and 36-58 568708007928 dsDNA-mimic protein; Reviewed; Region: PRK05094 568708007930 Ion transport protein; Region: Ion_trans; pfam00520 568708007931 Ion channel; Region: Ion_trans_2; pfam07885 568708007932 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 568708007933 Double zinc ribbon; Region: DZR; pfam12773 568708007934 6 probable transmembrane helices predicted for STM_MW17361 by TMHMM2.0 at aa 12-34, 44-66, 73-95, 139-161, 166-188 and 198-220 568708007936 Signal peptide predicted for STM_MW17361 by SignalP 2.0 HMM (Signal peptide probability 0.899) with cleavage site probability 0.369 between residues 28 and 29 568708007937 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 568708007938 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568708007939 Walker A/P-loop; other site 568708007940 ATP binding site [chemical binding]; other site 568708007941 Q-loop/lid; other site 568708007942 ABC transporter signature motif; other site 568708007943 Walker B; other site 568708007944 D-loop; other site 568708007945 H-loop/switch region; other site 568708007946 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568708007949 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 568708007950 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568708007951 Walker A/P-loop; other site 568708007952 ATP binding site [chemical binding]; other site 568708007953 Q-loop/lid; other site 568708007954 ABC transporter signature motif; other site 568708007955 Walker B; other site 568708007956 D-loop; other site 568708007957 H-loop/switch region; other site 568708007958 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568708007961 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 568708007962 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568708007963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708007964 dimer interface [polypeptide binding]; other site 568708007965 conserved gate region; other site 568708007966 ABC-ATPase subunit interface; other site 568708007967 6 probable transmembrane helices predicted for STM_MW17391 by TMHMM2.0 at aa 40-62, 103-125, 138-160, 164-183, 214-236 and 268-290 568708007969 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 568708007970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708007971 dimer interface [polypeptide binding]; other site 568708007972 conserved gate region; other site 568708007973 putative PBP binding loops; other site 568708007974 ABC-ATPase subunit interface; other site 568708007975 6 probable transmembrane helices predicted for STM_MW17401 by TMHMM2.0 at aa 13-30, 102-121, 134-156, 166-188, 228-250 and 278-300 568708007977 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 568708007978 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568708007979 peptide binding site [polypeptide binding]; other site 568708007981 1 probable transmembrane helix predicted for STM_MW17411 by TMHMM2.0 at aa 48-70 568708007982 hypothetical protein; Provisional; Region: PRK11111 568708007983 6 probable transmembrane helices predicted for STM_MW17431 by TMHMM2.0 at aa 10-32, 52-74, 78-100, 120-142, 146-168 and 189-211 568708007985 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 568708007986 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 568708007987 putative catalytic cysteine [active] 568708007988 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 568708007989 putative active site [active] 568708007990 metal binding site [ion binding]; metal-binding site 568708007993 thymidine kinase; Provisional; Region: PRK04296 568708007995 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 568708007996 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 568708007998 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 568708007999 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 568708008000 active site 568708008001 tetramer interface; other site 568708008003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708008004 active site 568708008005 response regulator of RpoS; Provisional; Region: PRK10693 568708008006 phosphorylation site [posttranslational modification] 568708008007 intermolecular recognition site; other site 568708008008 dimerization interface [polypeptide binding]; other site 568708008010 hypothetical protein; Provisional; Region: PRK10279 568708008011 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 568708008012 active site 568708008013 nucleophile elbow; other site 568708008015 SEC-C motif; Region: SEC-C; pfam02810 568708008016 hypothetical protein; Provisional; Region: PRK04233 568708008018 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 568708008019 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 568708008020 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 568708008021 putative active site [active] 568708008022 putative substrate binding site [chemical binding]; other site 568708008023 putative cosubstrate binding site; other site 568708008024 catalytic site [active] 568708008027 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 568708008028 Sel1-like repeats; Region: SEL1; smart00671 568708008029 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 568708008030 Sel1-like repeats; Region: SEL1; smart00671 568708008031 Sel1-like repeats; Region: SEL1; smart00671 568708008032 Sel1-like repeats; Region: SEL1; smart00671 568708008033 Sel1-like repeats; Region: SEL1; smart00671 568708008034 Sel1-like repeats; Region: SEL1; smart00671 568708008035 Sel1-like repeats; Region: SEL1; smart00671 568708008036 Sel1-like repeats; Region: SEL1; smart00671 568708008038 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 568708008040 5 probable transmembrane helices predicted for STM_MW17531 by TMHMM2.0 at aa 4-26, 47-69, 89-108, 127-149 and 184-206 568708008041 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 568708008043 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 568708008044 4Fe-4S binding domain; Region: Fer4; cl02805 568708008045 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 568708008046 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 568708008047 [4Fe-4S] binding site [ion binding]; other site 568708008048 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568708008049 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568708008050 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568708008051 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 568708008052 molybdopterin cofactor binding site; other site 568708008055 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 568708008056 12 probable transmembrane helices predicted for STM_MW17571 by TMHMM2.0 at aa 38-60, 75-97, 104-123, 133-155, 176-198, 213-235, 256-278, 288-310, 322-344, 348-370, 404-421 and 436-458 568708008058 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 568708008059 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 568708008060 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708008061 dimerization interface [polypeptide binding]; other site 568708008062 Histidine kinase; Region: HisKA_3; pfam07730 568708008063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708008064 ATP binding site [chemical binding]; other site 568708008065 Mg2+ binding site [ion binding]; other site 568708008066 G-X-G motif; other site 568708008067 Signal peptide predicted for STM_MW17581 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.674 between residues 33 and 34 568708008068 2 probable transmembrane helices predicted for STM_MW17581 by TMHMM2.0 at aa 15-37 and 154-176 568708008072 transcriptional regulator NarL; Provisional; Region: PRK10651 568708008073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708008074 active site 568708008075 phosphorylation site [posttranslational modification] 568708008076 intermolecular recognition site; other site 568708008077 dimerization interface [polypeptide binding]; other site 568708008078 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708008079 DNA binding residues [nucleotide binding] 568708008080 dimerization interface [polypeptide binding]; other site 568708008083 putative invasin; Provisional; Region: PRK10177 568708008084 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 568708008085 Signal peptide predicted for STM_MW17601 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.839 between residues 40 and 41 568708008086 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 568708008088 cation transport regulator; Reviewed; Region: chaB; PRK09582 568708008090 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 568708008091 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 568708008092 11 probable transmembrane helices predicted for STM_MW17631 by TMHMM2.0 at aa 13-32, 36-58, 71-93, 108-127, 139-161, 166-188, 220-237, 247-269, 290-312, 317-339 and 346-365 568708008094 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 568708008095 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 568708008097 hypothetical protein; Provisional; Region: PRK10941 568708008098 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 568708008099 hypothetical protein; Provisional; Region: PRK10278 568708008101 4 probable transmembrane helices predicted for STM_MW17661 by TMHMM2.0 at aa 5-27, 39-60, 70-92 and 104-123 568708008102 Signal peptide predicted for STM_MW17661 by SignalP 2.0 HMM (Signal peptide probability 0.644) with cleavage site probability 0.455 between residues 22 and 23 568708008103 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 568708008104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708008106 peptide chain release factor 1; Validated; Region: prfA; PRK00591 568708008107 This domain is found in peptide chain release factors; Region: PCRF; smart00937 568708008108 RF-1 domain; Region: RF-1; pfam00472 568708008111 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 568708008112 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 568708008113 tRNA; other site 568708008114 putative tRNA binding site [nucleotide binding]; other site 568708008115 putative NADP binding site [chemical binding]; other site 568708008116 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 568708008120 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 568708008121 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 568708008122 Signal peptide predicted for STM_MW17701 by SignalP 2.0 HMM (Signal peptide probability 0.782) with cleavage site probability 0.633 between residues 28 and 29 568708008124 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 568708008125 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568708008128 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 568708008129 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 568708008130 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568708008131 active site 568708008133 putative transporter; Provisional; Region: PRK11660 568708008134 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 568708008135 Sulfate transporter family; Region: Sulfate_transp; pfam00916 568708008136 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 568708008137 11 probable transmembrane helices predicted for STM_MW17731 by TMHMM2.0 at aa 25-47, 54-76, 91-113, 122-144, 169-191, 204-226, 269-291, 311-333, 338-360, 362-380 and 400-431 568708008140 hypothetical protein; Provisional; Region: PRK10692 568708008142 2 probable transmembrane helices predicted for STM_MW17741 by TMHMM2.0 at aa 7-29 and 39-61 568708008143 Signal peptide predicted for STM_MW17741 by SignalP 2.0 HMM (Signal peptide probability 0.830) with cleavage site probability 0.300 between residues 24 and 25 568708008144 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 568708008145 putative active site [active] 568708008146 catalytic residue [active] 568708008148 GTP-binding protein YchF; Reviewed; Region: PRK09601 568708008149 YchF GTPase; Region: YchF; cd01900 568708008150 G1 box; other site 568708008151 GTP/Mg2+ binding site [chemical binding]; other site 568708008152 Switch I region; other site 568708008153 G2 box; other site 568708008154 Switch II region; other site 568708008155 G3 box; other site 568708008156 G4 box; other site 568708008157 G5 box; other site 568708008158 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 568708008162 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 568708008163 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 568708008165 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 568708008166 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 568708008167 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 568708008168 Signal peptide predicted for STM_MW17781 by SignalP 2.0 HMM (Signal peptide probability 0.931) with cleavage site probability 0.921 between residues 45 and 46 568708008169 2 probable transmembrane helices predicted for STM_MW17781 by TMHMM2.0 at aa 20-39 and 326-348 568708008171 hydrogenase 1 large subunit; Provisional; Region: PRK10170 568708008172 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 568708008174 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 568708008176 4 probable transmembrane helices predicted for STM_MW17801 by TMHMM2.0 at aa 28-47, 67-89, 141-160 and 194-211 568708008177 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 568708008178 putative substrate-binding site; other site 568708008179 nickel binding site [ion binding]; other site 568708008181 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 568708008183 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 568708008184 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 568708008186 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 568708008187 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 568708008189 9 probable transmembrane helices predicted for STM_MW17841 by TMHMM2.0 at aa 20-42, 54-76, 96-118, 125-147, 186-208, 215-237, 387-409, 421-443 and 471-493 568708008190 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 568708008191 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 568708008193 8 probable transmembrane helices predicted for STM_MW17851 by TMHMM2.0 at aa 7-24, 80-102, 123-145, 160-182, 203-225, 258-280, 292-314 and 334-356 568708008194 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 568708008195 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 568708008196 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 568708008197 NAD(P) binding site [chemical binding]; other site 568708008200 trehalase; Provisional; Region: treA; PRK13271 568708008201 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 568708008202 Signal peptide predicted for STM_MW17881 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 34 and 35 568708008204 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 568708008205 3 probable transmembrane helices predicted for STM_MW17891 by TMHMM2.0 at aa 4-22, 27-49 and 59-81 568708008207 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 568708008208 Flagellar regulator YcgR; Region: YcgR; pfam07317 568708008209 PilZ domain; Region: PilZ; pfam07238 568708008212 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 568708008213 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568708008214 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568708008215 catalytic residue [active] 568708008217 Signal peptide predicted for STM_MW17911 by SignalP 2.0 HMM (Signal peptide probability 0.861) with cleavage site probability 0.723 between residues 19 and 20 568708008218 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 568708008219 dimer interface [polypeptide binding]; other site 568708008220 catalytic triad [active] 568708008222 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 568708008223 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 568708008224 TrkA-C domain; Region: TrkA_C; pfam02080 568708008225 Transporter associated domain; Region: CorC_HlyC; smart01091 568708008226 11 probable transmembrane helices predicted for STM_MW17931 by TMHMM2.0 at aa 4-26, 31-53, 57-74, 87-109, 119-141, 187-209, 232-254, 267-289, 299-321, 334-356 and 361-383 568708008230 alanine racemase; Reviewed; Region: dadX; PRK03646 568708008231 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 568708008232 active site 568708008233 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568708008234 substrate binding site [chemical binding]; other site 568708008235 catalytic residues [active] 568708008236 dimer interface [polypeptide binding]; other site 568708008239 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 568708008240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568708008242 SpoVR family protein; Provisional; Region: PRK11767 568708008243 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 568708008245 fatty acid metabolism regulator; Provisional; Region: PRK04984 568708008246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708008247 DNA-binding site [nucleotide binding]; DNA binding site 568708008248 FadR C-terminal domain; Region: FadR_C; pfam07840 568708008251 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 568708008252 transmembrane helices; other site 568708008254 12 probable transmembrane helices predicted for STM_MW17981 by TMHMM2.0 at aa 26-48, 61-83, 93-115, 128-145, 150-169, 197-219, 239-261, 299-331, 346-368, 389-411, 453-472 and 479-501 568708008255 disulfide bond formation protein B; Provisional; Region: PRK01749 568708008256 Signal peptide predicted for STM_MW17991 by SignalP 2.0 HMM (Signal peptide probability 0.854) with cleavage site probability 0.827 between residues 24 and 25 568708008258 4 probable transmembrane helices predicted for STM_MW17991 by TMHMM2.0 at aa 13-32, 42-64, 71-93 and 144-166 568708008259 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 568708008261 GnsA/GnsB family; Region: GnsAB; pfam08178 568708008263 hypothetical protein; Provisional; Region: PRK05170 568708008265 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568708008266 hypothetical protein; Provisional; Region: PRK10691 568708008268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 568708008270 septum formation inhibitor; Reviewed; Region: minC; PRK03511 568708008271 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 568708008272 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 568708008275 cell division inhibitor MinD; Provisional; Region: PRK10818 568708008276 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 568708008277 Switch I; other site 568708008278 Switch II; other site 568708008280 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 568708008282 ribonuclease D; Provisional; Region: PRK10829 568708008283 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 568708008284 catalytic site [active] 568708008285 putative active site [active] 568708008286 putative substrate binding site [chemical binding]; other site 568708008287 HRDC domain; Region: HRDC; cl02578 568708008290 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 568708008291 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 568708008292 acyl-activating enzyme (AAE) consensus motif; other site 568708008293 putative AMP binding site [chemical binding]; other site 568708008294 putative active site [active] 568708008295 putative CoA binding site [chemical binding]; other site 568708008297 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 568708008299 Signal peptide predicted for STM_MW18111 by SignalP 2.0 HMM (Signal peptide probability 0.888) with cleavage site probability 0.393 between residues 25 and 26 568708008300 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 568708008301 Glycoprotease family; Region: Peptidase_M22; pfam00814 568708008303 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 568708008304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 568708008305 DEAD_2; Region: DEAD_2; pfam06733 568708008306 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 568708008309 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 568708008310 homotrimer interaction site [polypeptide binding]; other site 568708008311 putative active site [active] 568708008313 hypothetical protein; Provisional; Region: PRK05114 568708008315 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 568708008316 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 568708008317 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 568708008320 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 568708008321 putative active site [active] 568708008322 putative CoA binding site [chemical binding]; other site 568708008323 nudix motif; other site 568708008324 metal binding site [ion binding]; metal-binding site 568708008326 L-serine deaminase; Provisional; Region: PRK15023 568708008327 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 568708008328 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 568708008331 phage resistance protein; Provisional; Region: PRK10551 568708008332 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 568708008333 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708008335 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 568708008336 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 568708008337 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568708008338 Transporter associated domain; Region: CorC_HlyC; smart01091 568708008340 7 probable transmembrane helices predicted for STM_MW18201 by TMHMM2.0 at aa 13-35, 48-70, 85-102, 123-145, 150-172, 185-207 and 212-231 568708008343 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 568708008344 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568708008345 active pocket/dimerization site; other site 568708008346 active site 568708008347 phosphorylation site [posttranslational modification] 568708008348 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 568708008349 active site 568708008350 phosphorylation site [posttranslational modification] 568708008353 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 568708008355 7 probable transmembrane helices predicted for STM_MW18231 by TMHMM2.0 at aa 5-27, 34-56, 66-88, 95-117, 143-165, 178-200 and 215-237 568708008356 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 568708008358 5 probable transmembrane helices predicted for STM_MW18241 by TMHMM2.0 at aa 105-127, 142-164, 185-207, 236-258 and 265-284 568708008359 hypothetical protein; Provisional; Region: PRK02913 568708008360 Signal peptide predicted for STM_MW18251 by SignalP 2.0 HMM (Signal peptide probability 0.693) with cleavage site probability 0.613 between residues 19 and 20 568708008362 2 probable transmembrane helices predicted for STM_MW18251 by TMHMM2.0 at aa 7-26 and 65-87 568708008363 hypothetical protein; Provisional; Region: PRK11469 568708008364 Domain of unknown function DUF; Region: DUF204; pfam02659 568708008365 Domain of unknown function DUF; Region: DUF204; pfam02659 568708008366 Signal peptide predicted for STM_MW18261 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 19 and 20 568708008367 6 probable transmembrane helices predicted for STM_MW18261 by TMHMM2.0 at aa 4-26, 39-61, 71-93, 106-128, 133-155 and 168-187 568708008369 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 568708008370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708008371 S-adenosylmethionine binding site [chemical binding]; other site 568708008373 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 568708008374 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568708008375 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568708008378 Signal peptide predicted for STM_MW18281 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.700 between residues 38 and 39 568708008379 1 probable transmembrane helix predicted for STM_MW18281 by TMHMM2.0 at aa 16-38 568708008380 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568708008381 DNA-binding site [nucleotide binding]; DNA binding site 568708008382 RNA-binding motif; other site 568708008384 YobH-like protein; Region: YobH; pfam13996 568708008385 Signal peptide predicted for STM_MW18301 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.962 between residues 33 and 34 568708008386 1 probable transmembrane helix predicted for STM_MW18301 by TMHMM2.0 at aa 7-29 568708008387 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 568708008388 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568708008389 dimerization interface [polypeptide binding]; other site 568708008390 putative Zn2+ binding site [ion binding]; other site 568708008391 putative DNA binding site [nucleotide binding]; other site 568708008392 Bacterial transcriptional regulator; Region: IclR; pfam01614 568708008395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708008396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568708008397 putative substrate translocation pore; other site 568708008398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708008399 12 probable transmembrane helices predicted for STM_MW18321 by TMHMM2.0 at aa 21-43, 53-75, 87-109, 113-132, 144-166, 171-193, 205-227, 231-249, 269-291, 306-328, 335-357 and 426-448 568708008401 heat shock protein HtpX; Provisional; Region: PRK05457 568708008403 4 probable transmembrane helices predicted for STM_MW18331 by TMHMM2.0 at aa 5-27, 32-54, 158-180 and 195-217 568708008405 Signal peptide predicted for STM_MW18331 by SignalP 2.0 HMM (Signal peptide probability 0.958) with cleavage site probability 0.237 between residues 32 and 33 568708008406 carboxy-terminal protease; Provisional; Region: PRK11186 568708008407 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 568708008408 protein binding site [polypeptide binding]; other site 568708008409 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 568708008410 Catalytic dyad [active] 568708008411 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 568708008414 Signal peptide predicted for STM_MW18341 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708008415 ProP expression regulator; Provisional; Region: PRK04950 568708008416 ProQ/FINO family; Region: ProQ; pfam04352 568708008418 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 568708008419 GAF domain; Region: GAF_2; pfam13185 568708008421 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 568708008422 Paraquat-inducible protein A; Region: PqiA; pfam04403 568708008423 Paraquat-inducible protein A; Region: PqiA; pfam04403 568708008424 8 probable transmembrane helices predicted for STM_MW18371 by TMHMM2.0 at aa 65-84, 119-141, 162-184, 188-210, 268-290, 310-339, 351-373 and 383-405 568708008426 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 568708008427 mce related protein; Region: MCE; pfam02470 568708008428 mce related protein; Region: MCE; pfam02470 568708008429 mce related protein; Region: MCE; pfam02470 568708008430 mce related protein; Region: MCE; pfam02470 568708008431 mce related protein; Region: MCE; pfam02470 568708008432 mce related protein; Region: MCE; pfam02470 568708008433 1 probable transmembrane helix predicted for STM_MW18381 by TMHMM2.0 at aa 22-41 568708008435 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 568708008436 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 568708008437 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 568708008439 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 568708008441 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 568708008443 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 568708008444 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568708008446 type III secretion protein SopE2; Provisional; Region: PRK15280 568708008447 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 568708008448 SopE GEF domain; Region: SopE_GEF; pfam07487 568708008451 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 568708008453 1 probable transmembrane helix predicted for STM_MW18471 by TMHMM2.0 at aa 55-77 568708008454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708008455 Coenzyme A binding pocket [chemical binding]; other site 568708008457 pfam_scan;Pfam:PF00872; E()=1.7E-98;score=329.2;query 9-372;description=Transposase_mut 568708008460 prophage 3 remnant 568708008462 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 568708008464 Signal peptide predicted for STM_MW18541 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 568708008465 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 568708008466 8 probable transmembrane helices predicted for STM_MW18551 by TMHMM2.0 at aa 10-32, 52-74, 94-113, 120-137, 152-174, 195-217, 227-249 and 270-288 568708008468 hypothetical protein; Provisional; Region: PRK10301 568708008470 Signal peptide predicted for STM_MW18561 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.834 between residues 26 and 27 568708008471 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 568708008473 Predicted amidohydrolase [General function prediction only]; Region: COG0388 568708008474 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 568708008476 exodeoxyribonuclease X; Provisional; Region: PRK07983 568708008477 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568708008478 active site 568708008479 catalytic site [active] 568708008480 substrate binding site [chemical binding]; other site 568708008482 protease 2; Provisional; Region: PRK10115 568708008483 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568708008486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 568708008487 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 568708008488 putative metal binding site [ion binding]; other site 568708008490 1 probable transmembrane helix predicted for STM_MW18611 by TMHMM2.0 at aa 52-74 568708008491 hypothetical protein; Provisional; Region: PRK13680 568708008492 Signal peptide predicted for STM_MW18621 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 21 and 22 568708008493 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 568708008495 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 568708008496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568708008497 ATP-grasp domain; Region: ATP-grasp; pfam02222 568708008499 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 568708008500 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 568708008501 active site 568708008502 intersubunit interface [polypeptide binding]; other site 568708008503 catalytic residue [active] 568708008505 phosphogluconate dehydratase; Validated; Region: PRK09054 568708008506 6-phosphogluconate dehydratase; Region: edd; TIGR01196 568708008508 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 568708008509 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 568708008510 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 568708008513 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 568708008514 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568708008515 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568708008516 putative active site [active] 568708008519 pyruvate kinase; Provisional; Region: PRK05826 568708008520 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 568708008521 domain interfaces; other site 568708008522 active site 568708008525 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 568708008526 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 568708008527 putative acyl-acceptor binding pocket; other site 568708008529 1 probable transmembrane helix predicted for STM_MW18701 by TMHMM2.0 at aa 21-43 568708008530 putative peptidase; Provisional; Region: PRK11649 568708008531 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 568708008532 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568708008533 Peptidase family M23; Region: Peptidase_M23; pfam01551 568708008537 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 568708008538 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 568708008539 metal binding site [ion binding]; metal-binding site 568708008541 Signal peptide predicted for STM_MW18721 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.924 between residues 42 and 43 568708008542 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 568708008543 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 568708008545 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 568708008546 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568708008547 ABC-ATPase subunit interface; other site 568708008548 dimer interface [polypeptide binding]; other site 568708008549 putative PBP binding regions; other site 568708008550 Signal peptide predicted for STM_MW18741 by SignalP 2.0 HMM (Signal peptide probability 0.958) with cleavage site probability 0.581 between residues 18 and 19 568708008552 7 probable transmembrane helices predicted for STM_MW18741 by TMHMM2.0 at aa 5-27, 48-70, 85-107, 127-145, 170-192, 213-235 and 239-256 568708008553 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 568708008554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708008555 Walker A motif; other site 568708008556 ATP binding site [chemical binding]; other site 568708008557 Walker B motif; other site 568708008558 arginine finger; other site 568708008559 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 568708008562 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 568708008563 RuvA N terminal domain; Region: RuvA_N; pfam01330 568708008564 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 568708008567 contains a frameshift after residue 80 568708008568 contains two frameshifts after residues 55 and 104; tmhmm; query 1-147 568708008569 hypothetical protein; Provisional; Region: PRK11470 568708008571 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 568708008572 active site 568708008573 putative DNA-binding cleft [nucleotide binding]; other site 568708008574 dimer interface [polypeptide binding]; other site 568708008576 hypothetical protein; Validated; Region: PRK00110 568708008578 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 568708008579 nudix motif; other site 568708008581 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 568708008582 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 568708008583 dimer interface [polypeptide binding]; other site 568708008584 anticodon binding site; other site 568708008585 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 568708008586 homodimer interface [polypeptide binding]; other site 568708008587 motif 1; other site 568708008588 active site 568708008589 motif 2; other site 568708008590 GAD domain; Region: GAD; pfam02938 568708008591 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568708008592 active site 568708008593 motif 3; other site 568708008597 Isochorismatase family; Region: Isochorismatase; pfam00857 568708008598 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 568708008599 catalytic triad [active] 568708008600 conserved cis-peptide bond; other site 568708008602 hypothetical protein; Provisional; Region: PRK10302 568708008604 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 568708008605 4 probable transmembrane helices predicted for STM_MW18871 by TMHMM2.0 at aa 4-22, 43-62, 72-89 and 102-124 568708008607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708008608 S-adenosylmethionine binding site [chemical binding]; other site 568708008610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708008611 S-adenosylmethionine binding site [chemical binding]; other site 568708008613 copper homeostasis protein CutC; Provisional; Region: PRK11572 568708008615 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 568708008616 putative metal binding site [ion binding]; other site 568708008618 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 568708008619 arginyl-tRNA synthetase; Region: argS; TIGR00456 568708008620 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 568708008621 active site 568708008622 HIGH motif; other site 568708008623 KMSK motif region; other site 568708008624 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 568708008625 tRNA binding surface [nucleotide binding]; other site 568708008626 anticodon binding site; other site 568708008630 penicillin-binding protein 2; Provisional; Region: PRK10795 568708008631 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568708008632 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568708008633 1 probable transmembrane helix predicted for STM_MW18931 by TMHMM2.0 at aa 12-34 568708008636 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 568708008638 Flagellar protein FlhE; Region: FlhE; pfam06366 568708008640 Signal peptide predicted for STM_MW18951 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.916 between residues 16 and 17 568708008641 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 568708008642 FHIPEP family; Region: FHIPEP; pfam00771 568708008644 7 probable transmembrane helices predicted for STM_MW18961 by TMHMM2.0 at aa 21-43, 47-64, 76-98, 118-140, 213-235, 250-272 and 293-315 568708008645 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 568708008646 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 568708008648 4 probable transmembrane helices predicted for STM_MW18971 by TMHMM2.0 at aa 33-50, 93-115, 146-168 and 189-211 568708008649 chemotaxis regulator CheZ; Provisional; Region: PRK11166 568708008651 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 568708008652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708008653 active site 568708008654 phosphorylation site [posttranslational modification] 568708008655 intermolecular recognition site; other site 568708008656 dimerization interface [polypeptide binding]; other site 568708008658 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 568708008659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708008660 active site 568708008661 phosphorylation site [posttranslational modification] 568708008662 intermolecular recognition site; other site 568708008663 dimerization interface [polypeptide binding]; other site 568708008664 CheB methylesterase; Region: CheB_methylest; pfam01339 568708008667 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 568708008668 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 568708008669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708008670 S-adenosylmethionine binding site [chemical binding]; other site 568708008673 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 568708008674 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 568708008675 dimer interface [polypeptide binding]; other site 568708008676 ligand binding site [chemical binding]; other site 568708008677 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708008678 dimerization interface [polypeptide binding]; other site 568708008679 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568708008680 dimer interface [polypeptide binding]; other site 568708008681 putative CheW interface [polypeptide binding]; other site 568708008684 2 probable transmembrane helices predicted for STM_MW19021 by TMHMM2.0 at aa 85-107 and 271-293 568708008686 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 568708008687 putative CheA interaction surface; other site 568708008689 chemotaxis protein CheA; Provisional; Region: PRK10547 568708008690 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 568708008691 putative binding surface; other site 568708008692 active site 568708008693 CheY binding; Region: CheY-binding; pfam09078 568708008694 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 568708008695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708008696 ATP binding site [chemical binding]; other site 568708008697 Mg2+ binding site [ion binding]; other site 568708008698 G-X-G motif; other site 568708008699 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 568708008705 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 568708008706 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 568708008707 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568708008708 ligand binding site [chemical binding]; other site 568708008710 1 probable transmembrane helix predicted for STM_MW19051 by TMHMM2.0 at aa 29-51 568708008711 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 568708008712 flagellar motor protein MotA; Validated; Region: PRK09110 568708008713 3 probable transmembrane helices predicted for STM_MW19061 by TMHMM2.0 at aa 10-32, 152-171 and 186-208 568708008715 transcriptional activator FlhC; Provisional; Region: PRK12722 568708008717 transcriptional activator FlhD; Provisional; Region: PRK02909 568708008719 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568708008720 Ligand Binding Site [chemical binding]; other site 568708008722 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 568708008723 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 568708008724 active site 568708008725 homotetramer interface [polypeptide binding]; other site 568708008727 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 568708008728 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 568708008730 DJ-1 family protein; Region: not_thiJ; TIGR01383 568708008731 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 568708008732 conserved cys residue [active] 568708008734 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 568708008735 Ferritin-like domain; Region: Ferritin; pfam00210 568708008736 ferroxidase diiron center [ion binding]; other site 568708008738 hypothetical protein; Provisional; Region: PRK09273 568708008739 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 568708008740 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 568708008742 YecR-like lipoprotein; Region: YecR; pfam13992 568708008743 Signal peptide predicted for STM_MW19161 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.508 between residues 24 and 25 568708008744 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 568708008745 Ferritin-like domain; Region: Ferritin; pfam00210 568708008746 ferroxidase diiron center [ion binding]; other site 568708008748 probable metal-binding protein; Region: matur_matur; TIGR03853 568708008750 tyrosine transporter TyrP; Provisional; Region: PRK15132 568708008751 aromatic amino acid transport protein; Region: araaP; TIGR00837 568708008752 Signal peptide predicted for STM_MW19191 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.653 between residues 28 and 29 568708008754 11 probable transmembrane helices predicted for STM_MW19191 by TMHMM2.0 at aa 7-29, 33-55, 81-103, 113-135, 148-167, 182-204, 216-235, 273-295, 308-330, 335-357 and 377-399 568708008755 hypothetical protein; Provisional; Region: PRK10396 568708008756 yecA family protein; Region: ygfB_yecA; TIGR02292 568708008757 SEC-C motif; Region: SEC-C; pfam02810 568708008759 glucose-6-phosphate 1-dehydrogenase; Region: PLN02640 568708008760 Signal peptide; signalp; query 1-23;cleavage_site_probability=0.249; 0.687 568708008761 1 probable transmembrane helix predicted for STM_MW19231 by TMHMM2.0 at aa 25-47 568708008762 it has a frameshift after residue 17 568708008763 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 568708008764 4 probable transmembrane helices predicted for STM_MW19241 by TMHMM2.0 at aa 7-29, 33-52, 121-143 and 147-169 568708008766 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 568708008767 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 568708008768 GIY-YIG motif/motif A; other site 568708008769 active site 568708008770 catalytic site [active] 568708008771 putative DNA binding site [nucleotide binding]; other site 568708008772 metal binding site [ion binding]; metal-binding site 568708008773 UvrB/uvrC motif; Region: UVR; pfam02151 568708008774 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 568708008775 Helix-hairpin-helix motif; Region: HHH; pfam00633 568708008780 response regulator; Provisional; Region: PRK09483 568708008781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708008782 active site 568708008783 phosphorylation site [posttranslational modification] 568708008784 intermolecular recognition site; other site 568708008785 dimerization interface [polypeptide binding]; other site 568708008786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708008787 DNA binding residues [nucleotide binding] 568708008788 dimerization interface [polypeptide binding]; other site 568708008791 hypothetical protein; Provisional; Region: PRK10613 568708008793 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 568708008794 Autoinducer binding domain; Region: Autoind_bind; pfam03472 568708008795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708008796 DNA binding residues [nucleotide binding] 568708008797 dimerization interface [polypeptide binding]; other site 568708008800 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 568708008801 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568708008802 Walker A/P-loop; other site 568708008803 ATP binding site [chemical binding]; other site 568708008804 Q-loop/lid; other site 568708008805 ABC transporter signature motif; other site 568708008806 Walker B; other site 568708008807 D-loop; other site 568708008808 H-loop/switch region; other site 568708008809 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568708008811 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568708008812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708008813 dimer interface [polypeptide binding]; other site 568708008814 conserved gate region; other site 568708008815 putative PBP binding loops; other site 568708008816 ABC-ATPase subunit interface; other site 568708008817 3 probable transmembrane helices predicted for STM_MW19311 by TMHMM2.0 at aa 20-42, 54-76 and 185-207 568708008819 D-cysteine desulfhydrase; Validated; Region: PRK03910 568708008820 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 568708008821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708008822 catalytic residue [active] 568708008824 cystine transporter subunit; Provisional; Region: PRK11260 568708008825 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568708008826 substrate binding pocket [chemical binding]; other site 568708008827 membrane-bound complex binding site; other site 568708008828 hinge residues; other site 568708008830 Signal peptide predicted for STM_MW19331 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 29 and 30 568708008831 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 568708008833 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 568708008834 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568708008835 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 568708008836 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568708008837 DNA binding residues [nucleotide binding] 568708008841 Transposase IS200 like; Region: Y1_Tnp; pfam01797 568708008843 flagellin; Validated; Region: PRK08026 568708008844 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 568708008845 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 568708008846 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 568708008850 flagellar capping protein; Reviewed; Region: fliD; PRK08032 568708008851 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 568708008852 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 568708008856 flagellar protein FliS; Validated; Region: fliS; PRK05685 568708008858 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 568708008860 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 568708008861 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 568708008862 active site 568708008863 Na/Ca binding site [ion binding]; other site 568708008864 catalytic site [active] 568708008866 lipoprotein; Provisional; Region: PRK10397 568708008867 Signal peptide predicted for STM_MW19441 by SignalP 2.0 HMM (Signal peptide probability 0.972) with cleavage site probability 0.835 between residues 19 and 20 568708008868 putative inner membrane protein; Provisional; Region: PRK11099 568708008869 10 probable transmembrane helices predicted for STM_MW19451 by TMHMM2.0 at aa 30-52, 96-118, 139-161, 166-188, 217-234, 244-266, 279-301, 306-328, 341-360 and 380-402 568708008871 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 568708008872 CPxP motif; other site 568708008874 1 probable transmembrane helix predicted for STM_MW19471 by TMHMM2.0 at aa 12-34 568708008875 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 568708008877 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 568708008878 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 568708008879 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 568708008880 Signal peptide predicted for STM_MW19491 by SignalP 2.0 HMM (Signal peptide probability 0.955) with cleavage site probability 0.949 between residues 46 and 47 568708008881 1 probable transmembrane helix predicted for STM_MW19491 by TMHMM2.0 at aa 26-45 568708008884 flagellar motor switch protein FliG; Region: fliG; TIGR00207 568708008885 FliG C-terminal domain; Region: FliG_C; pfam01706 568708008887 flagellar assembly protein H; Validated; Region: fliH; PRK05687 568708008888 Flagellar assembly protein FliH; Region: FliH; pfam02108 568708008890 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 568708008891 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 568708008892 Walker A motif/ATP binding site; other site 568708008893 Walker B motif; other site 568708008895 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 568708008896 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 568708008898 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 568708008899 flagellar hook-length control protein; Provisional; Region: PRK10118 568708008901 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 568708008902 Signal peptide predicted for STM_MW19551 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.450 between residues 30 and 31 568708008903 1 probable transmembrane helix predicted for STM_MW19551 by TMHMM2.0 at aa 13-35 568708008905 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 568708008906 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 568708008909 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 568708008910 flagellar motor switch protein; Validated; Region: fliN; PRK05698 568708008912 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 568708008913 1 probable transmembrane helix predicted for STM_MW19581 by TMHMM2.0 at aa 18-40 568708008915 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 568708008916 Signal peptide predicted for STM_MW19591 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.511 between residues 20 and 21 568708008917 5 probable transmembrane helices predicted for STM_MW19591 by TMHMM2.0 at aa 5-27, 47-69, 88-105, 185-207 and 214-236 568708008919 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 568708008920 Signal peptide predicted for STM_MW19601 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.942 between residues 40 and 41 568708008922 2 probable transmembrane helices predicted for STM_MW19601 by TMHMM2.0 at aa 20-42 and 52-74 568708008923 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 568708008925 6 probable transmembrane helices predicted for STM_MW19611 by TMHMM2.0 at aa 15-34, 41-58, 73-95, 132-154, 179-201 and 214-236 568708008926 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 568708008927 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708008928 DNA binding residues [nucleotide binding] 568708008929 dimerization interface [polypeptide binding]; other site 568708008931 hypothetical protein; Provisional; Region: PRK10708 568708008933 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 568708008935 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 568708008936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708008937 active site 568708008938 motif I; other site 568708008939 motif II; other site 568708008941 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 568708008942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568708008943 metal binding site [ion binding]; metal-binding site 568708008944 active site 568708008945 I-site; other site 568708008946 2 probable transmembrane helices predicted for STM_MW19661 by TMHMM2.0 at aa 20-42 and 358-380 568708008948 Uncharacterized small protein [Function unknown]; Region: COG5475 568708008950 hypothetical protein; Provisional; Region: PRK10062 568708008952 5 probable transmembrane helices predicted for STM_MW19681 by TMHMM2.0 at aa 78-100, 150-169, 173-195, 230-252 and 267-289 568708008953 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 568708008954 EamA-like transporter family; Region: EamA; pfam00892 568708008955 EamA-like transporter family; Region: EamA; pfam00892 568708008956 10 probable transmembrane helices predicted for STM_MW19691 by TMHMM2.0 at aa 7-29, 39-57, 69-87, 97-119, 126-145, 149-168, 175-197, 212-234, 241-260 and 270-292 568708008958 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 568708008959 additional DNA contacts [nucleotide binding]; other site 568708008960 mismatch recognition site; other site 568708008961 active site 568708008962 zinc binding site [ion binding]; other site 568708008963 DNA intercalation site [nucleotide binding]; other site 568708008965 DNA cytosine methylase; Provisional; Region: PRK10458 568708008966 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 568708008967 cofactor binding site; other site 568708008968 DNA binding site [nucleotide binding] 568708008969 substrate interaction site [chemical binding]; other site 568708008971 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 568708008972 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568708008973 Zn2+ binding site [ion binding]; other site 568708008974 Mg2+ binding site [ion binding]; other site 568708008976 2 probable transmembrane helices predicted for STM_MW19731 by TMHMM2.0 at aa 19-41 and 61-80 568708008977 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568708008978 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 568708008979 trimer interface [polypeptide binding]; other site 568708008980 eyelet of channel; other site 568708008981 Signal peptide predicted for STM_MW19741 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 568708008983 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568708008984 DNA-binding site [nucleotide binding]; DNA binding site 568708008985 RNA-binding motif; other site 568708008987 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 568708008988 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 568708008989 active site 568708008990 DNA binding site [nucleotide binding] 568708008991 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 568708008995 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 568708008996 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568708008997 Catalytic site [active] 568708008999 1 probable transmembrane helix predicted for STM_MW19801 by TMHMM2.0 at aa 21-43 568708009000 BTP3 568708009003 type III secretion system protein; Provisional; Region: PRK15383 568708009004 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 568708009005 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 568708009007 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 568708009008 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 568708009010 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 568708009012 Baseplate J-like protein; Region: Baseplate_J; cl01294 568708009014 Phage protein GP46; Region: GP46; pfam07409 568708009016 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 568708009018 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 568708009019 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 568708009021 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 568708009022 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 568708009024 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 568708009026 1 probable transmembrane helix predicted for STM_MW19921 by TMHMM2.0 at aa 35-57 568708009027 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 568708009028 Phage tail tube protein; Region: Tail_tube; pfam10618 568708009030 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 568708009031 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 568708009033 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 568708009035 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 568708009036 oligomerization interface [polypeptide binding]; other site 568708009038 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 568708009039 Phage capsid family; Region: Phage_capsid; pfam05065 568708009041 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 568708009043 Phage-related protein [Function unknown]; Region: COG4695 568708009044 Phage portal protein; Region: Phage_portal; pfam04860 568708009046 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 568708009048 Phage terminase, small subunit; Region: Terminase_4; pfam05119 568708009050 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 568708009051 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 568708009052 active site 568708009054 KilA-N domain; Region: KilA-N; pfam04383 568708009056 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 568708009058 Predicted chitinase [General function prediction only]; Region: COG3179 568708009059 catalytic residue [active] 568708009061 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 568708009063 3 probable transmembrane helices predicted for STM_MW20111 by TMHMM2.0 at aa 20-39, 52-69 and 79-101 568708009064 Protein of unknown function (DUF968); Region: DUF968; pfam06147 568708009066 KilA-N domain; Region: KilA-N; pfam04383 568708009068 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 568708009070 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 568708009072 PerC transcriptional activator; Region: PerC; pfam06069 568708009074 Helix-turn-helix domain; Region: HTH_36; pfam13730 568708009075 Ash protein family; Region: Phage_ASH; pfam10554 568708009076 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 568708009079 Predicted transcriptional regulator [Transcription]; Region: COG2932 568708009080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708009081 non-specific DNA binding site [nucleotide binding]; other site 568708009082 salt bridge; other site 568708009083 sequence-specific DNA binding site [nucleotide binding]; other site 568708009084 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568708009085 Catalytic site [active] 568708009088 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 568708009090 HD domain; Region: HD_3; cl17350 568708009091 Protein of unknown function DUF262; Region: DUF262; pfam03235 568708009092 Uncharacterized conserved protein [Function unknown]; Region: COG1479 568708009094 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 568708009095 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 568708009096 active site 568708009097 catalytic site [active] 568708009098 substrate binding site [chemical binding]; other site 568708009099 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 568708009100 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568708009101 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 568708009102 dimer interface [polypeptide binding]; other site 568708009103 active site 568708009104 Int/Topo IB signature motif; other site 568708009106 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 568708009108 putative protease; Region: PHA00666 568708009109 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 568708009110 Integrase; Region: Integrase_1; pfam12835 568708009112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 568708009113 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 568708009114 Sel1-like repeats; Region: SEL1; smart00671 568708009115 Sel1-like repeats; Region: SEL1; smart00671 568708009118 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 568708009119 Signal peptide predicted for STM_MW20391 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.547 between residues 22 and 23 568708009120 AMP nucleosidase; Provisional; Region: PRK08292 568708009121 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 568708009122 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 568708009125 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 568708009127 MATE family multidrug exporter; Provisional; Region: PRK10189 568708009128 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 568708009129 11 probable transmembrane helices predicted for STM_MW20451 by TMHMM2.0 at aa 49-71, 86-108, 128-150, 160-182, 194-216, 231-253, 266-286, 296-318, 353-375, 390-412 and 434-456 568708009131 L,D-transpeptidase; Provisional; Region: PRK10190 568708009132 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568708009134 1 probable transmembrane helix predicted for STM_MW20461 by TMHMM2.0 at aa 7-26 568708009135 Signal peptide predicted for STM_MW20461 by SignalP 2.0 HMM (Signal peptide probability 0.942) with cleavage site probability 0.772 between residues 21 and 22 568708009136 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 568708009137 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 568708009138 putative dimer interface [polypeptide binding]; other site 568708009139 active site pocket [active] 568708009140 putative cataytic base [active] 568708009142 cobalamin synthase; Reviewed; Region: cobS; PRK00235 568708009144 5 probable transmembrane helices predicted for STM_MW20481 by TMHMM2.0 at aa 33-55, 59-81, 109-131, 136-158 and 185-207 568708009145 Signal peptide predicted for STM_MW20481 by SignalP 2.0 HMM (Signal peptide probability 0.655) with cleavage site probability 0.651 between residues 22 and 23 568708009146 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 568708009147 homotrimer interface [polypeptide binding]; other site 568708009148 Walker A motif; other site 568708009149 GTP binding site [chemical binding]; other site 568708009150 Walker B motif; other site 568708009152 cobyric acid synthase; Provisional; Region: PRK00784 568708009153 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 568708009154 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 568708009155 catalytic triad [active] 568708009158 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 568708009159 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568708009160 Walker A/P-loop; other site 568708009161 ATP binding site [chemical binding]; other site 568708009162 Q-loop/lid; other site 568708009163 ABC transporter signature motif; other site 568708009164 Walker B; other site 568708009165 D-loop; other site 568708009166 H-loop/switch region; other site 568708009168 cobalt transport protein CbiQ; Provisional; Region: PRK15485 568708009170 4 probable transmembrane helices predicted for STM_MW20521 by TMHMM2.0 at aa 22-47, 62-84, 91-110 and 120-142 568708009171 cobalt transport protein CbiN; Provisional; Region: PRK02898 568708009173 2 probable transmembrane helices predicted for STM_MW20531 by TMHMM2.0 at aa 5-22 and 60-82 568708009174 Signal peptide predicted for STM_MW20531 by SignalP 2.0 HMM (Signal peptide probability 0.934) with cleavage site probability 0.796 between residues 24 and 25 568708009175 cobalt transport protein CbiM; Validated; Region: PRK08319 568708009176 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 568708009177 7 probable transmembrane helices predicted for STM_MW20541 by TMHMM2.0 at aa 15-34, 41-63, 78-100, 107-129, 139-161, 174-193 and 213-235 568708009179 Signal peptide predicted for STM_MW20541 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.732 between residues 35 and 36 568708009180 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 568708009181 active site 568708009182 SAM binding site [chemical binding]; other site 568708009183 homodimer interface [polypeptide binding]; other site 568708009185 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 568708009186 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 568708009187 active site 568708009188 C-terminal domain interface [polypeptide binding]; other site 568708009189 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 568708009190 active site 568708009191 N-terminal domain interface [polypeptide binding]; other site 568708009193 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 568708009194 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 568708009196 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 568708009197 active site 568708009198 SAM binding site [chemical binding]; other site 568708009199 homodimer interface [polypeptide binding]; other site 568708009201 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 568708009202 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 568708009203 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 568708009204 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 568708009208 1 probable transmembrane helix predicted for STM_MW20591 by TMHMM2.0 at aa 58-80 568708009209 Signal peptide predicted for STM_MW20591 by SignalP 2.0 HMM (Signal peptide probability 0.827) with cleavage site probability 0.735 between residues 22 and 23 568708009210 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 568708009211 active site 568708009212 SAM binding site [chemical binding]; other site 568708009213 homodimer interface [polypeptide binding]; other site 568708009215 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 568708009216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708009217 S-adenosylmethionine binding site [chemical binding]; other site 568708009219 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 568708009220 active site 568708009221 putative homodimer interface [polypeptide binding]; other site 568708009222 SAM binding site [chemical binding]; other site 568708009224 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 568708009226 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 568708009227 Precorrin-8X methylmutase; Region: CbiC; pfam02570 568708009229 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 568708009230 5 probable transmembrane helices predicted for STM_MW20651 by TMHMM2.0 at aa 52-74, 79-101, 155-177, 207-229 and 296-318 568708009232 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 568708009233 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 568708009234 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 568708009235 catalytic triad [active] 568708009238 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 568708009239 Sensory domain found in PocR; Region: PocR; pfam10114 568708009240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708009241 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568708009242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708009245 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 568708009246 amphipathic channel; other site 568708009247 Asn-Pro-Ala signature motifs; other site 568708009249 6 probable transmembrane helices predicted for STM_MW20681 by TMHMM2.0 at aa 13-35, 55-77, 84-106, 143-165, 178-200 and 230-252 568708009250 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 568708009251 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 568708009252 Hexamer interface [polypeptide binding]; other site 568708009253 Putative hexagonal pore residue; other site 568708009255 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 568708009256 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 568708009257 putative hexamer interface [polypeptide binding]; other site 568708009258 putative hexagonal pore; other site 568708009259 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 568708009260 putative hexamer interface [polypeptide binding]; other site 568708009261 putative hexagonal pore; other site 568708009263 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 568708009264 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 568708009265 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 568708009266 alpha-beta subunit interface [polypeptide binding]; other site 568708009267 alpha-gamma subunit interface [polypeptide binding]; other site 568708009268 active site 568708009269 substrate and K+ binding site; other site 568708009270 K+ binding site [ion binding]; other site 568708009271 cobalamin binding site [chemical binding]; other site 568708009273 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 568708009275 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 568708009277 Cell division protein FtsA; Region: FtsA; cl17206 568708009278 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 568708009280 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 568708009281 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 568708009282 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 568708009283 putative hexamer interface [polypeptide binding]; other site 568708009284 putative hexagonal pore; other site 568708009286 1 probable transmembrane helix predicted for STM_MW20761 by TMHMM2.0 at aa 12-31 568708009287 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 568708009288 Propanediol utilisation protein PduL; Region: PduL; pfam06130 568708009289 Propanediol utilisation protein PduL; Region: PduL; pfam06130 568708009291 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 568708009292 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 568708009293 Hexamer/Pentamer interface [polypeptide binding]; other site 568708009294 central pore; other site 568708009296 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 568708009297 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 568708009300 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 568708009301 putative catalytic cysteine [active] 568708009303 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 568708009304 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 568708009305 putative active site [active] 568708009306 metal binding site [ion binding]; metal-binding site 568708009308 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 568708009309 SLBB domain; Region: SLBB; pfam10531 568708009310 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 568708009311 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 568708009314 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 568708009315 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 568708009316 putative hexamer interface [polypeptide binding]; other site 568708009317 putative hexagonal pore; other site 568708009318 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 568708009319 putative hexamer interface [polypeptide binding]; other site 568708009320 putative hexagonal pore; other site 568708009322 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 568708009323 putative hexamer interface [polypeptide binding]; other site 568708009324 putative hexagonal pore; other site 568708009326 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 568708009327 G3 box; other site 568708009328 Switch II region; other site 568708009329 GTP/Mg2+ binding site [chemical binding]; other site 568708009330 G4 box; other site 568708009331 G5 box; other site 568708009333 propionate kinase; Reviewed; Region: PRK12397 568708009334 propionate/acetate kinase; Provisional; Region: PRK12379 568708009336 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 568708009338 hypothetical protein; Provisional; Region: PRK05423 568708009340 Predicted membrane protein [Function unknown]; Region: COG1289 568708009341 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 568708009343 6 probable transmembrane helices predicted for STM_MW20901 by TMHMM2.0 at aa 20-42, 47-66, 73-92, 96-113, 118-135 and 140-162 568708009344 DNA gyrase inhibitor; Provisional; Region: PRK10016 568708009346 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 568708009347 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 568708009348 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 568708009351 Signal peptide predicted for STM_MW20921 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24 568708009352 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 568708009353 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 568708009354 5 probable transmembrane helices predicted for STM_MW20931 by TMHMM2.0 at aa 15-37, 66-88, 93-115, 169-191 and 201-223 568708009356 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 568708009357 4Fe-4S binding domain; Region: Fer4; cl02805 568708009359 thiosulfate reductase PhsA; Provisional; Region: PRK15488 568708009360 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 568708009361 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 568708009362 putative [Fe4-S4] binding site [ion binding]; other site 568708009363 putative molybdopterin cofactor binding site [chemical binding]; other site 568708009364 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568708009365 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 568708009366 putative molybdopterin cofactor binding site; other site 568708009370 Signal peptide predicted for STM_MW20951 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 30 and 31 568708009373 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 568708009374 SopA-like central domain; Region: SopA; pfam13981 568708009375 SopA-like catalytic domain; Region: SopA_C; pfam13979 568708009376 exonuclease I; Provisional; Region: sbcB; PRK11779 568708009377 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 568708009378 active site 568708009379 catalytic site [active] 568708009380 substrate binding site [chemical binding]; other site 568708009381 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 568708009384 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568708009385 12 probable transmembrane helices predicted for STM_MW20991 by TMHMM2.0 at aa 20-38, 53-75, 96-118, 133-151, 158-180, 200-219, 240-262, 289-311, 342-364, 368-385, 398-417 and 422-439 568708009387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708009388 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 568708009389 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568708009390 dimerization interface [polypeptide binding]; other site 568708009393 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568708009394 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 568708009395 putative NAD(P) binding site [chemical binding]; other site 568708009397 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 568708009398 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 568708009399 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 568708009402 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 568708009403 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 568708009404 NAD binding site [chemical binding]; other site 568708009405 dimerization interface [polypeptide binding]; other site 568708009406 product binding site; other site 568708009407 substrate binding site [chemical binding]; other site 568708009408 zinc binding site [ion binding]; other site 568708009409 catalytic residues [active] 568708009411 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 568708009412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568708009413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708009414 homodimer interface [polypeptide binding]; other site 568708009415 catalytic residue [active] 568708009417 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 568708009418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708009419 active site 568708009420 motif I; other site 568708009421 motif II; other site 568708009422 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 568708009423 putative active site pocket [active] 568708009424 4-fold oligomerization interface [polypeptide binding]; other site 568708009425 metal binding residues [ion binding]; metal-binding site 568708009426 3-fold/trimer interface [polypeptide binding]; other site 568708009429 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 568708009430 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 568708009431 putative active site [active] 568708009432 oxyanion strand; other site 568708009433 catalytic triad [active] 568708009435 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 568708009436 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 568708009437 catalytic residues [active] 568708009439 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 568708009440 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 568708009441 substrate binding site [chemical binding]; other site 568708009442 glutamase interaction surface [polypeptide binding]; other site 568708009444 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 568708009445 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 568708009446 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 568708009447 metal binding site [ion binding]; metal-binding site 568708009450 chain length determinant protein WzzB; Provisional; Region: PRK15471 568708009451 Chain length determinant protein; Region: Wzz; pfam02706 568708009452 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 568708009453 2 probable transmembrane helices predicted for STM_MW21101 by TMHMM2.0 at aa 33-52 and 296-315 568708009455 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 568708009456 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 568708009457 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 568708009458 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 568708009462 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568708009463 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 568708009464 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 568708009467 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 568708009468 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 568708009469 Bacterial sugar transferase; Region: Bac_transf; pfam02397 568708009470 5 probable transmembrane helices predicted for STM_MW21131 by TMHMM2.0 at aa 15-37, 57-74, 89-108, 115-134 and 282-304 568708009472 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 568708009473 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 568708009474 active site 568708009475 substrate binding site [chemical binding]; other site 568708009476 metal binding site [ion binding]; metal-binding site 568708009480 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 568708009481 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 568708009482 Substrate binding site; other site 568708009483 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 568708009486 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 568708009487 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 568708009488 active site 568708009489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568708009491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568708009492 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 568708009494 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568708009495 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 568708009496 active site 568708009498 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 568708009499 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568708009500 12 probable transmembrane helices predicted for STM_MW21191 by TMHMM2.0 at aa 12-34, 47-69, 90-112, 132-154, 161-180, 190-212, 233-250, 270-292, 304-326, 341-360, 372-394 and 399-421 568708009502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568708009503 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 568708009504 NAD(P) binding site [chemical binding]; other site 568708009505 active site 568708009507 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 568708009508 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 568708009509 inhibitor-cofactor binding pocket; inhibition site 568708009510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708009511 catalytic residue [active] 568708009513 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 568708009514 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 568708009515 NAD binding site [chemical binding]; other site 568708009516 homotetramer interface [polypeptide binding]; other site 568708009517 homodimer interface [polypeptide binding]; other site 568708009518 substrate binding site [chemical binding]; other site 568708009519 active site 568708009521 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 568708009522 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 568708009523 substrate binding site; other site 568708009525 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 568708009526 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568708009527 catalytic loop [active] 568708009528 iron binding site [ion binding]; other site 568708009529 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 568708009530 FAD binding pocket [chemical binding]; other site 568708009531 FAD binding motif [chemical binding]; other site 568708009532 phosphate binding motif [ion binding]; other site 568708009533 beta-alpha-beta structure motif; other site 568708009534 NAD binding pocket [chemical binding]; other site 568708009538 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 568708009540 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 568708009541 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 568708009542 substrate binding site; other site 568708009543 tetramer interface; other site 568708009545 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 568708009546 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 568708009547 NADP binding site [chemical binding]; other site 568708009548 active site 568708009549 putative substrate binding site [chemical binding]; other site 568708009551 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 568708009552 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 568708009553 NAD binding site [chemical binding]; other site 568708009554 substrate binding site [chemical binding]; other site 568708009555 homodimer interface [polypeptide binding]; other site 568708009556 active site 568708009558 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 568708009559 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 568708009560 active site 568708009561 tetramer interface; other site 568708009563 Signal peptide predicted for STM_MW21291 by SignalP 2.0 HMM (Signal peptide probability 0.730) with cleavage site probability 0.694 between residues 22 and 23 568708009564 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 568708009565 Signal peptide predicted for STM_MW21301 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.968 between residues 31 and 32 568708009566 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 568708009567 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 568708009568 putative ADP-binding pocket [chemical binding]; other site 568708009570 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 568708009571 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 568708009573 colanic acid exporter; Provisional; Region: PRK10459 568708009574 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 568708009576 10 probable transmembrane helices predicted for STM_MW21331 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 165-187, 286-308, 323-340, 361-383, 387-409, 416-435 and 450-472 568708009577 Signal peptide predicted for STM_MW21331 by SignalP 2.0 HMM (Signal peptide probability 0.754) with cleavage site probability 0.750 between residues 33 and 34 568708009578 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 568708009579 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 568708009580 5 probable transmembrane helices predicted for STM_MW21341 by TMHMM2.0 at aa 12-34, 44-66, 79-101, 111-130 and 279-300 568708009582 phosphomannomutase CpsG; Provisional; Region: PRK15414 568708009583 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 568708009584 active site 568708009585 substrate binding site [chemical binding]; other site 568708009586 metal binding site [ion binding]; metal-binding site 568708009591 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 568708009592 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 568708009593 Substrate binding site; other site 568708009594 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 568708009597 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 568708009598 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 568708009600 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 568708009601 active site 568708009602 GDP-Mannose binding site [chemical binding]; other site 568708009603 dimer interface [polypeptide binding]; other site 568708009604 modified nudix motif 568708009605 metal binding site [ion binding]; metal-binding site 568708009607 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 568708009608 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 568708009609 NADP binding site [chemical binding]; other site 568708009610 active site 568708009611 putative substrate binding site [chemical binding]; other site 568708009613 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 568708009614 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 568708009615 NADP-binding site; other site 568708009616 homotetramer interface [polypeptide binding]; other site 568708009617 substrate binding site [chemical binding]; other site 568708009618 homodimer interface [polypeptide binding]; other site 568708009619 active site 568708009621 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 568708009622 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 568708009623 putative trimer interface [polypeptide binding]; other site 568708009624 putative active site [active] 568708009625 putative substrate binding site [chemical binding]; other site 568708009626 putative CoA binding site [chemical binding]; other site 568708009627 putative glycosyl transferase; Provisional; Region: PRK10063 568708009628 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 568708009629 metal-binding site 568708009631 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 568708009632 12 probable transmembrane helices predicted for STM_MW21441 by TMHMM2.0 at aa 7-25, 30-47, 54-76, 81-103, 116-138, 143-165, 172-189, 204-226, 246-268, 283-305, 326-348 and 368-390 568708009633 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 568708009634 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568708009635 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568708009637 putative acyl transferase; Provisional; Region: PRK10191 568708009638 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 568708009639 trimer interface [polypeptide binding]; other site 568708009640 active site 568708009641 substrate binding site [chemical binding]; other site 568708009642 CoA binding site [chemical binding]; other site 568708009643 putative glycosyl transferase; Provisional; Region: PRK10018 568708009644 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 568708009645 active site 568708009647 tyrosine kinase; Provisional; Region: PRK11519 568708009648 Chain length determinant protein; Region: Wzz; pfam02706 568708009649 Chain length determinant protein; Region: Wzz; cl15801 568708009650 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 568708009651 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568708009653 2 probable transmembrane helices predicted for STM_MW21481 by TMHMM2.0 at aa 31-53 and 426-448 568708009655 Low molecular weight phosphatase family; Region: LMWPc; cd00115 568708009656 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 568708009657 active site 568708009659 polysaccharide export protein Wza; Provisional; Region: PRK15078 568708009660 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 568708009663 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 568708009664 FOG: CBS domain [General function prediction only]; Region: COG0517 568708009665 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568708009666 Transporter associated domain; Region: CorC_HlyC; smart01091 568708009667 7 probable transmembrane helices predicted for STM_MW21511 by TMHMM2.0 at aa 13-35, 48-70, 80-99, 126-148, 153-172, 185-207 and 212-234 568708009671 putative assembly protein; Provisional; Region: PRK10833 568708009672 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 568708009674 1 probable transmembrane helix predicted for STM_MW21521 by TMHMM2.0 at aa 7-26 568708009675 Signal peptide predicted for STM_MW21521 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.492 between residues 25 and 26 568708009676 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 568708009677 trimer interface [polypeptide binding]; other site 568708009678 active site 568708009680 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 568708009681 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 568708009682 ATP-binding site [chemical binding]; other site 568708009683 Sugar specificity; other site 568708009684 Pyrimidine base specificity; other site 568708009686 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 568708009687 PAS domain S-box; Region: sensory_box; TIGR00229 568708009688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568708009689 putative active site [active] 568708009690 heme pocket [chemical binding]; other site 568708009691 PAS domain S-box; Region: sensory_box; TIGR00229 568708009692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568708009693 putative active site [active] 568708009694 heme pocket [chemical binding]; other site 568708009695 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568708009696 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568708009697 metal binding site [ion binding]; metal-binding site 568708009698 active site 568708009699 I-site; other site 568708009700 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708009701 10 probable transmembrane helices predicted for STM_MW21551 by TMHMM2.0 at aa 15-37, 64-86, 90-112, 124-146, 156-177, 189-208, 212-229, 236-258, 268-290 and 310-327 568708009707 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 568708009708 AlkA N-terminal domain; Region: AlkA_N; pfam06029 568708009709 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568708009710 minor groove reading motif; other site 568708009711 helix-hairpin-helix signature motif; other site 568708009712 substrate binding pocket [chemical binding]; other site 568708009713 active site 568708009716 putative chaperone; Provisional; Region: PRK11678 568708009717 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 568708009718 nucleotide binding site [chemical binding]; other site 568708009719 putative NEF/HSP70 interaction site [polypeptide binding]; other site 568708009720 SBD interface [polypeptide binding]; other site 568708009722 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 568708009723 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568708009724 HlyD family secretion protein; Region: HlyD_3; pfam13437 568708009725 Signal peptide predicted for STM_MW21581 by SignalP 2.0 HMM (Signal peptide probability 0.928) with cleavage site probability 0.356 between residues 34 and 35 568708009726 1 probable transmembrane helix predicted for STM_MW21581 by TMHMM2.0 at aa 7-26 568708009728 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 568708009729 Protein export membrane protein; Region: SecD_SecF; cl14618 568708009731 11 probable transmembrane helices predicted for STM_MW21591 by TMHMM2.0 at aa 15-37, 345-362, 367-389, 396-418, 438-460, 472-494, 535-557, 867-889, 909-931, 968-990 and 1000-1022 568708009732 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 568708009734 10 probable transmembrane helices predicted for STM_MW21601 by TMHMM2.0 at aa 7-29, 336-353, 360-382, 434-456, 463-485, 525-547, 853-875, 895-917, 948-970 and 985-1007 568708009735 putative transporter; Provisional; Region: PRK10504 568708009736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708009737 putative substrate translocation pore; other site 568708009738 13 probable transmembrane helices predicted for STM_MW21611 by TMHMM2.0 at aa 12-34, 47-69, 76-98, 102-124, 136-158, 168-190, 197-214, 224-243, 255-277, 287-309, 330-352, 395-417 and 430-452 568708009740 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 568708009741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708009742 dimerization interface [polypeptide binding]; other site 568708009743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708009744 dimer interface [polypeptide binding]; other site 568708009745 phosphorylation site [posttranslational modification] 568708009746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708009747 ATP binding site [chemical binding]; other site 568708009748 Mg2+ binding site [ion binding]; other site 568708009749 G-X-G motif; other site 568708009750 2 probable transmembrane helices predicted for STM_MW21621 by TMHMM2.0 at aa 13-35 and 168-190 568708009754 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 568708009755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708009756 active site 568708009757 phosphorylation site [posttranslational modification] 568708009758 intermolecular recognition site; other site 568708009759 dimerization interface [polypeptide binding]; other site 568708009760 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708009761 DNA binding site [nucleotide binding] 568708009764 PcfJ-like protein; Region: PcfJ; pfam14284 568708009765 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 568708009767 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 568708009768 putative protease; Provisional; Region: PRK15452 568708009769 Peptidase family U32; Region: Peptidase_U32; pfam01136 568708009771 type III secretion system protein; Provisional; Region: PRK15383 568708009772 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 568708009773 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 568708009775 2 probable transmembrane helices predicted for STM_MW21701 by TMHMM2.0 at aa 48-70 and 85-107 568708009776 lipid kinase; Reviewed; Region: PRK13054 568708009777 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 568708009779 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 568708009780 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 568708009781 putative active site; other site 568708009782 catalytic residue [active] 568708009784 nucleoside transporter; Region: 2A0110; TIGR00889 568708009785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708009786 putative substrate translocation pore; other site 568708009788 12 probable transmembrane helices predicted for STM_MW21731 by TMHMM2.0 at aa 7-29, 39-61, 70-87, 97-119, 132-154, 159-181, 211-233, 243-265, 274-293, 297-319, 339-358 and 378-400 568708009789 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 568708009791 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568708009792 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 568708009793 substrate binding site [chemical binding]; other site 568708009794 ATP binding site [chemical binding]; other site 568708009796 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568708009797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708009798 DNA-binding site [nucleotide binding]; DNA binding site 568708009799 UTRA domain; Region: UTRA; pfam07702 568708009802 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 568708009803 dimer interface [polypeptide binding]; other site 568708009804 substrate binding site [chemical binding]; other site 568708009805 ATP binding site [chemical binding]; other site 568708009807 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 568708009808 substrate binding site [chemical binding]; other site 568708009809 multimerization interface [polypeptide binding]; other site 568708009810 ATP binding site [chemical binding]; other site 568708009812 Predicted integral membrane protein [Function unknown]; Region: COG5455 568708009813 Signal peptide predicted for STM_MW21791 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 568708009815 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 568708009816 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 568708009817 Signal peptide predicted for STM_MW21801 by SignalP 2.0 HMM (Signal peptide probability 0.783) with cleavage site probability 0.726 between residues 19 and 20 568708009818 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 568708009819 PapC N-terminal domain; Region: PapC_N; pfam13954 568708009820 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568708009821 PapC C-terminal domain; Region: PapC_C; pfam13953 568708009823 Signal peptide predicted for STM_MW21811 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.557 between residues 24 and 25 568708009824 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 568708009825 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708009826 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708009829 1 probable transmembrane helix predicted for STM_MW21821 by TMHMM2.0 at aa 7-29 568708009830 Signal peptide predicted for STM_MW21821 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 18 and 19 568708009831 fimbrial chaperone protein; Provisional; Region: PRK15220 568708009833 Signal peptide predicted for STM_MW21831 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23 568708009834 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 568708009836 antiporter inner membrane protein; Provisional; Region: PRK11670 568708009837 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 568708009838 Walker A motif; other site 568708009840 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 568708009841 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 568708009842 active site 568708009843 HIGH motif; other site 568708009844 KMSKS motif; other site 568708009845 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 568708009846 tRNA binding surface [nucleotide binding]; other site 568708009847 anticodon binding site; other site 568708009848 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 568708009849 dimer interface [polypeptide binding]; other site 568708009850 putative tRNA-binding site [nucleotide binding]; other site 568708009853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 568708009854 Signal peptide predicted for STM_MW21871 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.426 between residues 24 and 25 568708009856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 568708009857 Signal peptide predicted for STM_MW21881 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.839 between residues 22 and 23 568708009859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 568708009860 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 568708009861 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 568708009863 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 568708009864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708009865 active site 568708009866 phosphorylation site [posttranslational modification] 568708009867 intermolecular recognition site; other site 568708009868 dimerization interface [polypeptide binding]; other site 568708009869 LytTr DNA-binding domain; Region: LytTR; pfam04397 568708009872 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 568708009873 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 568708009874 GAF domain; Region: GAF; pfam01590 568708009875 Histidine kinase; Region: His_kinase; pfam06580 568708009876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708009877 ATP binding site [chemical binding]; other site 568708009878 Mg2+ binding site [ion binding]; other site 568708009879 G-X-G motif; other site 568708009883 6 probable transmembrane helices predicted for STM_MW21911 by TMHMM2.0 at aa 4-23, 44-63, 73-95, 107-129, 139-161 and 168-190 568708009885 transcriptional regulator MirA; Provisional; Region: PRK15043 568708009886 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 568708009887 DNA binding residues [nucleotide binding] 568708009889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708009890 putative PBP binding loops; other site 568708009891 ABC-ATPase subunit interface; other site 568708009892 6 probable transmembrane helices predicted for STM_MW21941 by TMHMM2.0 at aa 46-68, 92-114, 127-149, 159-181, 202-224 and 239-261 568708009894 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 568708009895 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 568708009896 Walker A/P-loop; other site 568708009897 ATP binding site [chemical binding]; other site 568708009898 Q-loop/lid; other site 568708009899 ABC transporter signature motif; other site 568708009900 Walker B; other site 568708009901 D-loop; other site 568708009902 H-loop/switch region; other site 568708009903 CBS domain; Region: CBS; pfam00571 568708009906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708009907 dimer interface [polypeptide binding]; other site 568708009908 conserved gate region; other site 568708009909 ABC-ATPase subunit interface; other site 568708009910 10 probable transmembrane helices predicted for STM_MW21961 by TMHMM2.0 at aa 13-33, 48-70, 75-97, 107-126, 139-161, 187-209, 216-238, 248-270, 328-350 and 360-382 568708009912 Signal peptide predicted for STM_MW21961 by SignalP 2.0 HMM (Signal peptide probability 0.931) with cleavage site probability 0.866 between residues 26 and 27 568708009913 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568708009915 Signal peptide predicted for STM_MW21971 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 568708009916 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 568708009917 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 568708009918 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 568708009921 Signal peptide predicted for STM_MW21981 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 568708009922 D-lactate dehydrogenase; Provisional; Region: PRK11183 568708009923 FAD binding domain; Region: FAD_binding_4; pfam01565 568708009924 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 568708009927 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 568708009928 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 568708009930 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 568708009931 5 probable transmembrane helices predicted for STM_MW22011 by TMHMM2.0 at aa 33-55, 65-87, 108-130, 135-157 and 170-192 568708009933 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568708009934 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 568708009935 5 probable transmembrane helices predicted for STM_MW22021 by TMHMM2.0 at aa 21-43, 53-72, 100-122, 137-159 and 172-189 568708009937 oxidoreductase; Provisional; Region: PRK12743 568708009938 classical (c) SDRs; Region: SDR_c; cd05233 568708009939 NAD(P) binding site [chemical binding]; other site 568708009940 active site 568708009942 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 568708009944 Signal peptide predicted for STM_MW22041 by SignalP 2.0 HMM (Signal peptide probability 0.951) with cleavage site probability 0.550 between residues 20 and 21 568708009945 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 568708009946 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 568708009947 FMN binding site [chemical binding]; other site 568708009948 active site 568708009949 catalytic residues [active] 568708009950 substrate binding site [chemical binding]; other site 568708009952 salicylate hydroxylase; Provisional; Region: PRK08163 568708009953 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568708009955 Signal peptide predicted for STM_MW22071 by SignalP 2.0 HMM (Signal peptide probability 0.896) with cleavage site probability 0.421 between residues 24 and 25 568708009956 1 probable transmembrane helix predicted for STM_MW22071 by TMHMM2.0 at aa 7-24 568708009957 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 568708009958 maleylacetoacetate isomerase; Region: maiA; TIGR01262 568708009959 C-terminal domain interface [polypeptide binding]; other site 568708009960 GSH binding site (G-site) [chemical binding]; other site 568708009961 putative dimer interface [polypeptide binding]; other site 568708009962 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 568708009963 dimer interface [polypeptide binding]; other site 568708009964 N-terminal domain interface [polypeptide binding]; other site 568708009965 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 568708009968 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568708009969 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568708009971 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 568708009972 Cupin domain; Region: Cupin_2; pfam07883 568708009973 Cupin domain; Region: Cupin_2; pfam07883 568708009975 benzoate transport; Region: 2A0115; TIGR00895 568708009976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708009977 putative substrate translocation pore; other site 568708009978 12 probable transmembrane helices predicted for STM_MW22111 by TMHMM2.0 at aa 23-45, 60-82, 89-108, 113-135, 148-170, 175-197, 253-275, 290-312, 319-338, 342-364, 385-407 and 412-434 568708009981 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 568708009982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708009983 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568708009984 dimerization interface [polypeptide binding]; other site 568708009987 hypothetical protein; Provisional; Region: PRK01821 568708009988 4 probable transmembrane helices predicted for STM_MW22131 by TMHMM2.0 at aa 7-29, 34-56, 63-85 and 95-117 568708009990 hypothetical protein; Provisional; Region: PRK10711 568708009991 Signal peptide predicted for STM_MW22141 by SignalP 2.0 HMM (Signal peptide probability 0.908) with cleavage site probability 0.836 between residues 23 and 24 568708009992 5 probable transmembrane helices predicted for STM_MW22141 by TMHMM2.0 at aa 5-24, 34-56, 91-113, 140-162 and 206-228 568708009994 cytidine deaminase; Provisional; Region: PRK09027 568708009995 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 568708009996 active site 568708009997 catalytic motif [active] 568708009998 Zn binding site [ion binding]; other site 568708009999 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 568708010000 active site 568708010001 catalytic motif [active] 568708010002 Zn binding site [ion binding]; other site 568708010005 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568708010006 putative active site [active] 568708010007 Signal peptide predicted for STM_MW22161 by SignalP 2.0 HMM (Signal peptide probability 0.917) with cleavage site probability 0.904 between residues 22 and 23 568708010008 1 probable transmembrane helix predicted for STM_MW22161 by TMHMM2.0 at aa 5-27 568708010010 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 568708010012 2 probable transmembrane helices predicted for STM_MW22171 by TMHMM2.0 at aa 7-26 and 57-79 568708010013 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 568708010014 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568708010015 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568708010018 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 568708010019 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 568708010020 homodimer interface [polypeptide binding]; other site 568708010021 active site 568708010022 FMN binding site [chemical binding]; other site 568708010023 substrate binding site [chemical binding]; other site 568708010025 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568708010026 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568708010027 TM-ABC transporter signature motif; other site 568708010028 9 probable transmembrane helices predicted for STM_MW22201 by TMHMM2.0 at aa 20-42, 49-68, 100-122, 127-149, 179-201, 222-244, 259-281, 286-308 and 312-330 568708010030 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568708010031 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 568708010032 Walker A/P-loop; other site 568708010033 ATP binding site [chemical binding]; other site 568708010034 Q-loop/lid; other site 568708010035 ABC transporter signature motif; other site 568708010036 Walker B; other site 568708010037 D-loop; other site 568708010038 H-loop/switch region; other site 568708010039 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 568708010041 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 568708010042 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 568708010043 ligand binding site [chemical binding]; other site 568708010044 calcium binding site [ion binding]; other site 568708010046 Signal peptide predicted for STM_MW22221 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.967 between residues 23 and 24 568708010047 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 568708010048 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708010049 DNA binding site [nucleotide binding] 568708010050 domain linker motif; other site 568708010051 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 568708010052 dimerization interface (closed form) [polypeptide binding]; other site 568708010053 ligand binding site [chemical binding]; other site 568708010056 Predicted membrane protein [Function unknown]; Region: COG2311 568708010057 hypothetical protein; Provisional; Region: PRK10835 568708010058 9 probable transmembrane helices predicted for STM_MW22241 by TMHMM2.0 at aa 12-34, 49-71, 83-102, 107-123, 130-152, 199-221, 233-255, 308-330 and 337-359 568708010060 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 568708010061 GTP cyclohydrolase I; Provisional; Region: PLN03044 568708010062 active site 568708010064 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 568708010065 S-formylglutathione hydrolase; Region: PLN02442 568708010067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708010068 non-specific DNA binding site [nucleotide binding]; other site 568708010069 salt bridge; other site 568708010070 sequence-specific DNA binding site [nucleotide binding]; other site 568708010072 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 568708010073 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 568708010074 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 568708010077 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 568708010078 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568708010079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708010080 motif II; other site 568708010082 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 568708010083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708010084 putative substrate translocation pore; other site 568708010085 11 probable transmembrane helices predicted for STM_MW22301 by TMHMM2.0 at aa 29-46, 69-91, 103-125, 160-182, 189-208, 240-262, 295-314, 324-343, 348-370, 385-407 and 412-434 568708010087 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 568708010088 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568708010089 N-terminal plug; other site 568708010090 ligand-binding site [chemical binding]; other site 568708010093 Signal peptide predicted for STM_MW22311 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.794 between residues 25 and 26 568708010094 lysine transporter; Provisional; Region: PRK10836 568708010096 12 probable transmembrane helices predicted for STM_MW22321 by TMHMM2.0 at aa 21-43, 53-75, 103-125, 130-152, 159-181, 196-218, 245-267, 287-309, 343-365, 369-391, 412-434 and 444-466 568708010097 Signal peptide predicted for STM_MW22321 by SignalP 2.0 HMM (Signal peptide probability 0.888) with cleavage site probability 0.755 between residues 46 and 47 568708010098 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 568708010099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708010100 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 568708010101 putative dimerization interface [polypeptide binding]; other site 568708010104 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 568708010105 Signal peptide predicted for STM_MW22341 by SignalP 2.0 HMM (Signal peptide probability 0.940) with cleavage site probability 0.753 between residues 40 and 41 568708010106 8 probable transmembrane helices predicted for STM_MW22341 by TMHMM2.0 at aa 13-35, 39-61, 100-122, 132-151, 163-185, 262-284, 291-313 and 323-345 568708010108 endonuclease IV; Provisional; Region: PRK01060 568708010109 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 568708010110 AP (apurinic/apyrimidinic) site pocket; other site 568708010111 DNA interaction; other site 568708010112 Metal-binding active site; metal-binding site 568708010113 Signal peptide predicted for STM_MW22351 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.981 between residues 21 and 22 568708010115 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 568708010116 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 568708010117 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568708010118 active site 568708010119 P-loop; other site 568708010120 phosphorylation site [posttranslational modification] 568708010121 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 568708010122 9 probable transmembrane helices predicted for STM_MW22361 by TMHMM2.0 at aa 236-258, 271-293, 303-325, 345-367, 377-399, 412-434, 464-481, 488-508 and 528-550 568708010125 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 568708010126 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568708010127 putative substrate binding site [chemical binding]; other site 568708010128 putative ATP binding site [chemical binding]; other site 568708010130 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 568708010131 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568708010132 active site 568708010133 phosphorylation site [posttranslational modification] 568708010134 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568708010135 dimerization domain swap beta strand [polypeptide binding]; other site 568708010136 regulatory protein interface [polypeptide binding]; other site 568708010137 active site 568708010138 regulatory phosphorylation site [posttranslational modification]; other site 568708010141 sugar efflux transporter B; Provisional; Region: PRK15011 568708010142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708010143 putative substrate translocation pore; other site 568708010144 Signal peptide predicted for STM_MW22391 by SignalP 2.0 HMM (Signal peptide probability 0.639) with cleavage site probability 0.599 between residues 32 and 33 568708010145 12 probable transmembrane helices predicted for STM_MW22391 by TMHMM2.0 at aa 20-42, 52-71, 84-101, 105-124, 145-167, 172-194, 221-243, 253-275, 282-304, 308-330, 350-367 and 371-390 568708010147 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 568708010148 2 probable transmembrane helices predicted for STM_MW22401 by TMHMM2.0 at aa 21-43 and 184-203 568708010149 elongation factor P; Provisional; Region: PRK04542 568708010150 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 568708010151 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 568708010152 RNA binding site [nucleotide binding]; other site 568708010153 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 568708010154 RNA binding site [nucleotide binding]; other site 568708010158 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 568708010159 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 568708010160 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 568708010162 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 568708010163 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 568708010164 active site 568708010165 5 probable transmembrane helices predicted for STM_MW22441 by TMHMM2.0 at aa 7-26, 64-83, 95-117, 162-184 and 191-213 568708010167 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 568708010168 NlpC/P60 family; Region: NLPC_P60; pfam00877 568708010169 Signal peptide predicted for STM_MW22451 by SignalP 2.0 HMM (Signal peptide probability 0.929) with cleavage site probability 0.402 between residues 33 and 34 568708010171 phage resistance protein; Provisional; Region: PRK10551 568708010172 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 568708010173 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708010174 2 probable transmembrane helices predicted for STM_MW22461 by TMHMM2.0 at aa 12-34 and 236-258 568708010176 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568708010177 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 568708010178 Signal peptide predicted for STM_MW22471 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 568708010180 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 568708010181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708010182 dimer interface [polypeptide binding]; other site 568708010183 conserved gate region; other site 568708010184 putative PBP binding loops; other site 568708010185 ABC-ATPase subunit interface; other site 568708010186 6 probable transmembrane helices predicted for STM_MW22481 by TMHMM2.0 at aa 9-31, 133-155, 168-190, 224-246, 283-305 and 329-348 568708010188 microcin C ABC transporter permease; Provisional; Region: PRK15021 568708010189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708010190 dimer interface [polypeptide binding]; other site 568708010191 conserved gate region; other site 568708010192 ABC-ATPase subunit interface; other site 568708010193 Signal peptide predicted for STM_MW22491 by SignalP 2.0 HMM (Signal peptide probability 0.788) with cleavage site probability 0.585 between residues 38 and 39 568708010194 6 probable transmembrane helices predicted for STM_MW22491 by TMHMM2.0 at aa 21-43, 142-164, 177-199, 203-222, 254-276 and 306-328 568708010196 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 568708010197 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568708010198 Walker A/P-loop; other site 568708010199 ATP binding site [chemical binding]; other site 568708010200 Q-loop/lid; other site 568708010201 ABC transporter signature motif; other site 568708010202 Walker B; other site 568708010203 D-loop; other site 568708010204 H-loop/switch region; other site 568708010205 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568708010206 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568708010207 Walker A/P-loop; other site 568708010208 ATP binding site [chemical binding]; other site 568708010209 Q-loop/lid; other site 568708010210 ABC transporter signature motif; other site 568708010211 Walker B; other site 568708010212 D-loop; other site 568708010213 H-loop/switch region; other site 568708010216 hypothetical protein; Provisional; Region: PRK11835 568708010217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708010218 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 568708010219 putative substrate translocation pore; other site 568708010220 12 probable transmembrane helices predicted for STM_MW22521 by TMHMM2.0 at aa 7-26, 41-63, 76-98, 102-124, 137-159, 163-185, 219-241, 251-273, 286-308, 313-332, 344-366 and 370-389 568708010222 Signal peptide predicted for STM_MW22521 by SignalP 2.0 HMM (Signal peptide probability 0.870) with cleavage site probability 0.504 between residues 25 and 26 568708010223 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 568708010224 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568708010225 RNA binding surface [nucleotide binding]; other site 568708010226 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 568708010227 active site 568708010228 uracil binding [chemical binding]; other site 568708010231 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 568708010232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568708010233 ATP binding site [chemical binding]; other site 568708010234 putative Mg++ binding site [ion binding]; other site 568708010235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708010236 nucleotide binding region [chemical binding]; other site 568708010237 ATP-binding site [chemical binding]; other site 568708010238 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 568708010241 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 568708010242 5S rRNA interface [nucleotide binding]; other site 568708010243 CTC domain interface [polypeptide binding]; other site 568708010244 L16 interface [polypeptide binding]; other site 568708010246 2 probable transmembrane helices predicted for STM_MW22561 by TMHMM2.0 at aa 20-42 and 52-74 568708010247 Nucleoid-associated protein [General function prediction only]; Region: COG3081 568708010248 nucleoid-associated protein NdpA; Validated; Region: PRK00378 568708010250 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 568708010251 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 568708010252 Sulfatase; Region: Sulfatase; cl17466 568708010253 5 probable transmembrane helices predicted for STM_MW22581 by TMHMM2.0 at aa 21-43, 58-80, 85-103, 135-157 and 169-191 568708010255 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 568708010256 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568708010257 Catalytic site [active] 568708010258 DinI-like family; Region: DinI; cl11630 568708010260 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 568708010262 9 probable transmembrane helices predicted for STM_MW22611 by TMHMM2.0 at aa 12-31, 35-57, 70-92, 133-155, 162-184, 188-210, 223-245, 299-321 and 334-353 568708010263 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 568708010265 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 568708010267 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 568708010268 Phage head maturation protease [General function prediction only]; Region: COG3740 568708010270 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 568708010271 Phage-related protein [Function unknown]; Region: COG4695; cl01923 568708010273 2 probable transmembrane helices predicted for STM_MW22671 by TMHMM2.0 at aa 26-48 and 55-74 568708010274 pfam_scan;Pfam:PF07693; E()=3.2E-66;score=223.2;query 15-316;description=KAP_NTPase 568708010276 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 568708010278 Protein of unknown function (DUF968); Region: DUF968; pfam06147 568708010280 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 568708010281 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 568708010282 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 568708010283 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 568708010284 Leucine-rich repeats; other site 568708010285 Substrate binding site [chemical binding]; other site 568708010289 DinI-like family; Region: DinI; cl11630 568708010291 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 568708010293 2 probable transmembrane helices predicted for STM_MW22761 by TMHMM2.0 at aa 7-26 and 108-126 568708010294 Signal peptide predicted for STM_MW22761 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.956 between residues 20 and 21 568708010295 transcriptional regulator NarP; Provisional; Region: PRK10403 568708010296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708010297 active site 568708010298 phosphorylation site [posttranslational modification] 568708010299 intermolecular recognition site; other site 568708010300 dimerization interface [polypeptide binding]; other site 568708010301 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708010302 DNA binding residues [nucleotide binding] 568708010303 dimerization interface [polypeptide binding]; other site 568708010306 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 568708010307 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 568708010309 3 probable transmembrane helices predicted for STM_MW22781 by TMHMM2.0 at aa 2-24, 103-125 and 150-169 568708010310 Signal peptide predicted for STM_MW22781 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 22 and 23 568708010311 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 568708010312 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 568708010313 catalytic residues [active] 568708010314 central insert; other site 568708010316 Signal peptide predicted for ATM_MW22782 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.742 between residues 30 and 31 568708010317 1 probable transmembrane helix predicted for ATM_MW22782 by TMHMM2.0 at aa 5-24 568708010318 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 568708010319 15 probable transmembrane helices predicted for STM_MW22783 by TMHMM2.0 at aa 5-27, 40-62, 95-114, 121-143, 176-198, 211-233, 248-265, 277-299, 314-332, 353-375, 390-412, 425-444, 449-468, 481-503 and 610-629 568708010321 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 568708010323 Signal peptide predicted for STM_MW22784 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.877 between residues 29 and 30 568708010324 1 probable transmembrane helix predicted for STM_MW22784 by TMHMM2.0 at aa 7-29 568708010325 heme exporter protein CcmC; Region: ccmC; TIGR01191 568708010327 6 probable transmembrane helices predicted for STM_MW22785 by TMHMM2.0 at aa 24-46, 66-88, 95-117, 132-151, 158-180 and 207-229 568708010328 heme exporter protein CcmB; Region: ccmB; TIGR01190 568708010330 6 probable transmembrane helices predicted for STM_MW22786 by TMHMM2.0 at aa 20-39, 43-65, 96-118, 128-150, 157-179 and 194-216 568708010331 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 568708010332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708010333 Walker A/P-loop; other site 568708010334 ATP binding site [chemical binding]; other site 568708010335 Q-loop/lid; other site 568708010336 ABC transporter signature motif; other site 568708010337 Walker B; other site 568708010338 D-loop; other site 568708010339 H-loop/switch region; other site 568708010341 cytochrome c-type protein NapC; Provisional; Region: PRK10617 568708010342 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 568708010344 1 probable transmembrane helix predicted for STM_MW22801 by TMHMM2.0 at aa 21-43 568708010345 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 568708010347 Signal peptide predicted for STM_MW22811 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 27 and 28 568708010348 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 568708010349 4Fe-4S binding domain; Region: Fer4_5; pfam12801 568708010350 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 568708010351 4 probable transmembrane helices predicted for STM_MW22821 by TMHMM2.0 at aa 33-55, 75-97, 138-160 and 170-192 568708010352 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 568708010354 Signal peptide predicted for STM_MW22831 by SignalP 2.0 HMM (Signal peptide probability 0.733) with cleavage site probability 0.366 between residues 41 and 42 568708010355 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 568708010356 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 568708010357 [4Fe-4S] binding site [ion binding]; other site 568708010358 molybdopterin cofactor binding site; other site 568708010359 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 568708010360 molybdopterin cofactor binding site; other site 568708010364 Signal peptide predicted for STM_MW22841 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.977 between residues 31 and 32 568708010365 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 568708010367 ferredoxin-type protein; Provisional; Region: PRK10194 568708010368 4Fe-4S binding domain; Region: Fer4; cl02805 568708010370 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 568708010371 secondary substrate binding site; other site 568708010372 primary substrate binding site; other site 568708010373 inhibition loop; other site 568708010374 dimerization interface [polypeptide binding]; other site 568708010375 Signal peptide predicted for STM_MW22871 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 20 and 21 568708010377 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 568708010378 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568708010379 Walker A/P-loop; other site 568708010380 ATP binding site [chemical binding]; other site 568708010381 Q-loop/lid; other site 568708010382 ABC transporter signature motif; other site 568708010383 Walker B; other site 568708010384 D-loop; other site 568708010385 H-loop/switch region; other site 568708010386 6 probable transmembrane helices predicted for STM_MW22881 by TMHMM2.0 at aa 15-37, 50-72, 120-142, 149-171, 238-260 and 272-294 568708010388 Signal peptide predicted for STM_MW22881 by SignalP 2.0 HMM (Signal peptide probability 0.714) with cleavage site probability 0.503 between residues 29 and 30 568708010389 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 568708010390 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 568708010391 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 568708010392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708010393 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 568708010394 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 568708010395 DNA binding site [nucleotide binding] 568708010396 active site 568708010401 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 568708010402 ApbE family; Region: ApbE; pfam02424 568708010404 Signal peptide predicted for STM_MW22911 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.796 between residues 19 and 20 568708010405 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 568708010406 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568708010408 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 568708010409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708010410 ATP binding site [chemical binding]; other site 568708010411 G-X-G motif; other site 568708010412 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 568708010413 putative binding surface; other site 568708010414 active site 568708010415 Signal peptide predicted for STM_MW22931 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.489 between residues 40 and 41 568708010416 2 probable transmembrane helices predicted for STM_MW22931 by TMHMM2.0 at aa 20-42 and 308-330 568708010419 transcriptional regulator RcsB; Provisional; Region: PRK10840 568708010420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708010421 active site 568708010422 phosphorylation site [posttranslational modification] 568708010423 intermolecular recognition site; other site 568708010424 dimerization interface [polypeptide binding]; other site 568708010425 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708010426 DNA binding residues [nucleotide binding] 568708010427 dimerization interface [polypeptide binding]; other site 568708010430 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 568708010431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708010432 dimer interface [polypeptide binding]; other site 568708010433 phosphorylation site [posttranslational modification] 568708010434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708010435 ATP binding site [chemical binding]; other site 568708010436 Mg2+ binding site [ion binding]; other site 568708010437 G-X-G motif; other site 568708010438 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 568708010439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708010440 active site 568708010441 phosphorylation site [posttranslational modification] 568708010442 intermolecular recognition site; other site 568708010443 dimerization interface [polypeptide binding]; other site 568708010446 2 probable transmembrane helices predicted for STM_MW22951 by TMHMM2.0 at aa 20-42 and 314-333 568708010449 Signal peptide predicted for STM_MW22951 by SignalP 2.0 HMM (Signal peptide probability 0.907) with cleavage site probability 0.300 between residues 32 and 33 568708010450 DNA gyrase subunit A; Validated; Region: PRK05560 568708010451 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 568708010452 CAP-like domain; other site 568708010453 active site 568708010454 primary dimer interface [polypeptide binding]; other site 568708010455 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568708010456 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568708010457 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568708010458 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568708010459 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568708010460 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568708010463 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 568708010464 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 568708010465 active site pocket [active] 568708010468 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 568708010469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708010470 putative substrate translocation pore; other site 568708010471 12 probable transmembrane helices predicted for STM_MW22981 by TMHMM2.0 at aa 20-42, 55-77, 84-103, 109-131, 144-166, 176-198, 247-269, 284-306, 315-334, 339-361, 368-390 and 400-422 568708010473 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568708010474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708010475 DNA-binding site [nucleotide binding]; DNA binding site 568708010476 FCD domain; Region: FCD; pfam07729 568708010479 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 568708010480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708010481 S-adenosylmethionine binding site [chemical binding]; other site 568708010483 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 568708010484 ATP cone domain; Region: ATP-cone; pfam03477 568708010485 Class I ribonucleotide reductase; Region: RNR_I; cd01679 568708010486 active site 568708010487 dimer interface [polypeptide binding]; other site 568708010488 catalytic residues [active] 568708010489 effector binding site; other site 568708010490 R2 peptide binding site; other site 568708010494 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 568708010495 dimer interface [polypeptide binding]; other site 568708010496 putative radical transfer pathway; other site 568708010497 diiron center [ion binding]; other site 568708010498 tyrosyl radical; other site 568708010500 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568708010501 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568708010502 catalytic loop [active] 568708010503 iron binding site [ion binding]; other site 568708010505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568708010506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708010507 putative substrate translocation pore; other site 568708010509 12 probable transmembrane helices predicted for STM_MW23041 by TMHMM2.0 at aa 13-35, 45-64, 76-95, 100-122, 135-154, 164-186, 212-234, 239-261, 273-290, 295-317, 330-352 and 357-379 568708010510 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 568708010511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708010512 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568708010513 dimerization interface [polypeptide binding]; other site 568708010516 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 568708010517 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 568708010518 active site 568708010519 catalytic site [active] 568708010520 metal binding site [ion binding]; metal-binding site 568708010522 1 probable transmembrane helix predicted for STM_MW23061 by TMHMM2.0 at aa 7-26 568708010523 Signal peptide predicted for STM_MW23061 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.882 between residues 25 and 26 568708010524 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 568708010525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708010526 putative substrate translocation pore; other site 568708010527 12 probable transmembrane helices predicted for STM_MW23071 by TMHMM2.0 at aa 28-45, 65-87, 94-116, 120-142, 161-183, 188-207, 254-273, 293-312, 319-341, 351-373, 386-408 and 418-437 568708010529 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 568708010530 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568708010531 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 568708010534 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 568708010535 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 568708010537 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 568708010538 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 568708010539 Cysteine-rich domain; Region: CCG; pfam02754 568708010540 Cysteine-rich domain; Region: CCG; pfam02754 568708010542 deubiquitinase SseL; Provisional; Region: PRK14848 568708010543 hypothetical protein; Provisional; Region: PRK03673 568708010544 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 568708010546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708010547 D-galactonate transporter; Region: 2A0114; TIGR00893 568708010548 putative substrate translocation pore; other site 568708010549 12 probable transmembrane helices predicted for STM_MW23141 by TMHMM2.0 at aa 13-30, 52-74, 79-101, 107-129, 142-164, 174-196, 241-263, 273-295, 308-325, 329-351, 358-380 and 395-417 568708010551 L-rhamnonate dehydratase; Provisional; Region: PRK15440 568708010552 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 568708010553 putative active site pocket [active] 568708010554 putative metal binding site [ion binding]; other site 568708010557 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568708010558 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568708010559 Bacterial transcriptional regulator; Region: IclR; pfam01614 568708010562 hypothetical protein; Provisional; Region: PRK03673 568708010563 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 568708010564 putative MPT binding site; other site 568708010565 Competence-damaged protein; Region: CinA; cl00666 568708010567 YfaZ precursor; Region: YfaZ; pfam07437 568708010568 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 568708010570 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 568708010572 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 568708010573 catalytic core [active] 568708010575 1 probable transmembrane helix predicted for STM_MW23201 by TMHMM2.0 at aa 13-35 568708010576 Signal peptide predicted for STM_MW23201 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.614 between residues 33 and 34 568708010577 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 568708010578 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 568708010579 inhibitor-cofactor binding pocket; inhibition site 568708010580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708010581 catalytic residue [active] 568708010583 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 568708010584 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 568708010585 Ligand binding site; other site 568708010586 Putative Catalytic site; other site 568708010587 DXD motif; other site 568708010589 2 probable transmembrane helices predicted for STM_MW23221 by TMHMM2.0 at aa 235-257 and 272-294 568708010590 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 568708010591 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 568708010592 active site 568708010593 substrate binding site [chemical binding]; other site 568708010594 cosubstrate binding site; other site 568708010595 catalytic site [active] 568708010596 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 568708010597 active site 568708010598 hexamer interface [polypeptide binding]; other site 568708010599 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 568708010600 NAD binding site [chemical binding]; other site 568708010601 substrate binding site [chemical binding]; other site 568708010602 active site 568708010606 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 568708010607 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 568708010608 putative active site [active] 568708010609 putative catalytic site [active] 568708010610 putative Zn binding site [ion binding]; other site 568708010612 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 568708010613 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 568708010615 12 probable transmembrane helices predicted for STM_MW23251 by TMHMM2.0 at aa 7-29, 82-104, 113-135, 139-156, 163-185, 205-227, 258-280, 290-307, 314-331, 346-368, 381-400 and 405-424 568708010616 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 568708010618 3 probable transmembrane helices predicted for STM_MW23261 by TMHMM2.0 at aa 36-58, 63-85 and 92-110 568708010619 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 568708010620 Signal peptide predicted for STM_MW23271 by SignalP 2.0 HMM (Signal peptide probability 0.940) with cleavage site probability 0.916 between residues 31 and 32 568708010621 4 probable transmembrane helices predicted for STM_MW23271 by TMHMM2.0 at aa 5-27, 42-64, 71-90 and 100-122 568708010622 signal transduction protein PmrD; Provisional; Region: PRK15450 568708010624 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 568708010625 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 568708010626 acyl-activating enzyme (AAE) consensus motif; other site 568708010627 putative AMP binding site [chemical binding]; other site 568708010628 putative active site [active] 568708010629 putative CoA binding site [chemical binding]; other site 568708010631 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 568708010632 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 568708010633 active site 568708010635 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568708010636 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 568708010637 substrate binding site [chemical binding]; other site 568708010638 oxyanion hole (OAH) forming residues; other site 568708010639 trimer interface [polypeptide binding]; other site 568708010641 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 568708010643 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 568708010644 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 568708010645 dimer interface [polypeptide binding]; other site 568708010646 tetramer interface [polypeptide binding]; other site 568708010647 PYR/PP interface [polypeptide binding]; other site 568708010648 TPP binding site [chemical binding]; other site 568708010649 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 568708010650 TPP-binding site; other site 568708010653 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 568708010654 isochorismate synthases; Region: isochor_syn; TIGR00543 568708010656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708010657 Coenzyme A binding pocket [chemical binding]; other site 568708010659 ribonuclease BN; Region: true_RNase_BN; TIGR02649 568708010661 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 568708010662 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 568708010663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708010664 active site 568708010665 phosphorylation site [posttranslational modification] 568708010666 intermolecular recognition site; other site 568708010667 dimerization interface [polypeptide binding]; other site 568708010670 von Willebrand factor; Region: vWF_A; pfam12450 568708010671 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 568708010672 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 568708010673 metal ion-dependent adhesion site (MIDAS); other site 568708010674 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 568708010676 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 568708010677 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568708010678 11 probable transmembrane helices predicted for STM_MW23391 by TMHMM2.0 at aa 12-34, 65-87, 99-121, 141-163, 176-198, 208-230, 237-259, 269-291, 311-333, 348-370 and 390-412 568708010680 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 568708010681 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568708010682 14 probable transmembrane helices predicted for STM_MW23401 by TMHMM2.0 at aa 4-18, 30-49, 81-103, 115-134, 139-161, 174-196, 222-244, 251-273, 288-307, 314-336, 341-363, 384-406, 416-438 and 459-481 568708010684 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 568708010685 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 568708010686 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568708010687 16 probable transmembrane helices predicted for STM_MW23411 by TMHMM2.0 at aa 4-21, 28-50, 84-106, 113-132, 136-158, 171-193, 213-235, 248-267, 277-299, 306-328, 332-354, 375-397, 412-434, 455-477, 492-514 and 590-612 568708010690 Signal peptide predicted for STM_MW23411 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.565 between residues 26 and 27 568708010691 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 568708010692 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 568708010694 5 probable transmembrane helices predicted for STM_MW23421 by TMHMM2.0 at aa 4-22, 29-51, 56-78, 91-113 and 133-155 568708010695 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 568708010696 4Fe-4S binding domain; Region: Fer4; pfam00037 568708010697 4Fe-4S binding domain; Region: Fer4; pfam00037 568708010699 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 568708010700 9 probable transmembrane helices predicted for STM_MW23441 by TMHMM2.0 at aa 13-35, 50-69, 81-103, 113-135, 155-174, 184-206, 235-257, 267-289 and 302-324 568708010702 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 568708010703 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568708010704 catalytic loop [active] 568708010705 iron binding site [ion binding]; other site 568708010706 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 568708010707 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 568708010708 [4Fe-4S] binding site [ion binding]; other site 568708010709 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 568708010715 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 568708010716 SLBB domain; Region: SLBB; pfam10531 568708010717 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 568708010721 NADH dehydrogenase subunit E; Validated; Region: PRK07539 568708010722 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 568708010723 putative dimer interface [polypeptide binding]; other site 568708010724 [2Fe-2S] cluster binding site [ion binding]; other site 568708010726 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 568708010727 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 568708010728 NADH dehydrogenase subunit D; Validated; Region: PRK06075 568708010731 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 568708010733 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 568708010735 3 probable transmembrane helices predicted for STM_MW23501 by TMHMM2.0 at aa 15-37, 68-90 and 100-122 568708010736 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 568708010737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708010738 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 568708010739 putative dimerization interface [polypeptide binding]; other site 568708010742 aminotransferase AlaT; Validated; Region: PRK09265 568708010743 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568708010744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708010745 homodimer interface [polypeptide binding]; other site 568708010746 catalytic residue [active] 568708010748 5'-nucleotidase; Provisional; Region: PRK03826 568708010750 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 568708010751 transmembrane helices; other site 568708010752 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 568708010753 TrkA-C domain; Region: TrkA_C; pfam02080 568708010754 TrkA-C domain; Region: TrkA_C; pfam02080 568708010755 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 568708010756 11 probable transmembrane helices predicted for STM_MW23551 by TMHMM2.0 at aa 5-22, 29-51, 61-83, 96-118, 138-160, 173-195, 427-449, 462-480, 500-522, 542-564 and 584-606 568708010759 Signal peptide predicted for STM_MW23551 by SignalP 2.0 HMM (Signal peptide probability 0.836) with cleavage site probability 0.754 between residues 20 and 21 568708010760 putative phosphatase; Provisional; Region: PRK11587 568708010761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708010762 motif II; other site 568708010764 hypothetical protein; Validated; Region: PRK05445 568708010766 hypothetical protein; Provisional; Region: PRK01816 568708010768 2 probable transmembrane helices predicted for STM_MW23581 by TMHMM2.0 at aa 46-65 and 69-91 568708010769 propionate/acetate kinase; Provisional; Region: PRK12379 568708010770 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 568708010772 phosphate acetyltransferase; Reviewed; Region: PRK05632 568708010773 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568708010774 DRTGG domain; Region: DRTGG; pfam07085 568708010775 phosphate acetyltransferase; Region: pta; TIGR00651 568708010778 hypothetical protein; Provisional; Region: PRK11588 568708010779 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 568708010781 11 probable transmembrane helices predicted for STM_MW23611 by TMHMM2.0 at aa 19-41, 106-127, 148-165, 175-197, 204-226, 230-252, 287-309, 314-336, 349-371, 398-415 and 481-503 568708010782 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 568708010783 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568708010784 PYR/PP interface [polypeptide binding]; other site 568708010785 dimer interface [polypeptide binding]; other site 568708010786 TPP binding site [chemical binding]; other site 568708010787 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568708010790 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 568708010791 TPP-binding site [chemical binding]; other site 568708010792 dimer interface [polypeptide binding]; other site 568708010794 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 568708010796 11 probable transmembrane helices predicted for STM_MW23641 by TMHMM2.0 at aa 10-32, 39-61, 95-114, 121-143, 147-169, 226-243, 258-280, 310-332, 342-364, 377-399 and 423-445 568708010797 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 568708010798 active site 568708010799 P-loop; other site 568708010800 phosphorylation site [posttranslational modification] 568708010802 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568708010803 active site 568708010804 phosphorylation site [posttranslational modification] 568708010806 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568708010807 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708010808 DNA binding site [nucleotide binding] 568708010809 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 568708010810 putative dimerization interface [polypeptide binding]; other site 568708010811 putative ligand binding site [chemical binding]; other site 568708010814 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 568708010815 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 568708010816 nudix motif; other site 568708010818 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 568708010819 active site 568708010820 metal binding site [ion binding]; metal-binding site 568708010821 homotetramer interface [polypeptide binding]; other site 568708010823 glutathione S-transferase; Provisional; Region: PRK15113 568708010824 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 568708010825 C-terminal domain interface [polypeptide binding]; other site 568708010826 GSH binding site (G-site) [chemical binding]; other site 568708010827 dimer interface [polypeptide binding]; other site 568708010828 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 568708010829 N-terminal domain interface [polypeptide binding]; other site 568708010830 putative dimer interface [polypeptide binding]; other site 568708010831 putative substrate binding pocket (H-site) [chemical binding]; other site 568708010833 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 568708010834 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 568708010835 C-terminal domain interface [polypeptide binding]; other site 568708010836 GSH binding site (G-site) [chemical binding]; other site 568708010837 dimer interface [polypeptide binding]; other site 568708010838 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 568708010839 N-terminal domain interface [polypeptide binding]; other site 568708010840 putative dimer interface [polypeptide binding]; other site 568708010841 active site 568708010844 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 568708010845 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 568708010846 putative NAD(P) binding site [chemical binding]; other site 568708010847 putative active site [active] 568708010850 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 568708010851 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568708010852 Walker A/P-loop; other site 568708010853 ATP binding site [chemical binding]; other site 568708010854 Q-loop/lid; other site 568708010855 ABC transporter signature motif; other site 568708010856 Walker B; other site 568708010857 D-loop; other site 568708010858 H-loop/switch region; other site 568708010860 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568708010861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708010862 dimer interface [polypeptide binding]; other site 568708010863 conserved gate region; other site 568708010864 putative PBP binding loops; other site 568708010865 ABC-ATPase subunit interface; other site 568708010866 4 probable transmembrane helices predicted for STM_MW23741 by TMHMM2.0 at aa 25-47, 57-79, 167-189 and 199-221 568708010868 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568708010869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708010870 dimer interface [polypeptide binding]; other site 568708010871 conserved gate region; other site 568708010872 putative PBP binding loops; other site 568708010873 ABC-ATPase subunit interface; other site 568708010874 5 probable transmembrane helices predicted for STM_MW23751 by TMHMM2.0 at aa 15-37, 58-80, 90-108, 149-171 and 191-213 568708010876 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 568708010877 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568708010878 substrate binding pocket [chemical binding]; other site 568708010879 membrane-bound complex binding site; other site 568708010880 hinge residues; other site 568708010882 Signal peptide predicted for STM_MW23761 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 22 and 23 568708010883 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 568708010884 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568708010885 substrate binding pocket [chemical binding]; other site 568708010886 membrane-bound complex binding site; other site 568708010887 hinge residues; other site 568708010889 1 probable transmembrane helix predicted for STM_MW23771 by TMHMM2.0 at aa 5-24 568708010890 Signal peptide predicted for STM_MW23771 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.969 between residues 22 and 23 568708010891 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 568708010892 Flavoprotein; Region: Flavoprotein; pfam02441 568708010894 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 568708010895 12 probable transmembrane helices predicted for STM_MW23791 by TMHMM2.0 at aa 25-47, 57-79, 86-108, 128-150, 163-185, 209-231, 243-265, 292-314, 334-356, 366-388, 409-431 and 435-457 568708010897 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 568708010898 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 568708010899 dimer interface [polypeptide binding]; other site 568708010900 active site 568708010901 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568708010902 substrate binding site [chemical binding]; other site 568708010903 catalytic residue [active] 568708010905 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 568708010906 12 probable transmembrane helices predicted for STM_MW23811 by TMHMM2.0 at aa 7-29, 39-61, 82-101, 116-138, 151-173, 193-215, 235-257, 281-303, 332-354, 358-380, 403-425 and 435-457 568708010908 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 568708010909 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 568708010910 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568708010911 catalytic residue [active] 568708010914 PAS fold; Region: PAS_4; pfam08448 568708010915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 568708010916 putative active site [active] 568708010917 heme pocket [chemical binding]; other site 568708010918 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 568708010919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708010920 Walker A motif; other site 568708010921 ATP binding site [chemical binding]; other site 568708010922 Walker B motif; other site 568708010923 arginine finger; other site 568708010924 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568708010928 amidophosphoribosyltransferase; Provisional; Region: PRK09246 568708010929 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 568708010930 active site 568708010931 tetramer interface [polypeptide binding]; other site 568708010932 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568708010933 active site 568708010936 colicin V production protein; Provisional; Region: PRK10845 568708010937 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 568708010939 4 probable transmembrane helices predicted for STM_MW23851 by TMHMM2.0 at aa 4-26, 31-53, 63-85 and 98-120 568708010940 cell division protein DedD; Provisional; Region: PRK11633 568708010941 Sporulation related domain; Region: SPOR; pfam05036 568708010943 1 probable transmembrane helix predicted for STM_MW23861 by TMHMM2.0 at aa 10-27 568708010944 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 568708010945 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568708010946 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568708010949 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 568708010950 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 568708010952 hypothetical protein; Provisional; Region: PRK10847 568708010953 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568708010954 4 probable transmembrane helices predicted for STM_MW23891 by TMHMM2.0 at aa 27-49, 71-93, 158-180 and 190-208 568708010956 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 568708010957 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 568708010958 dimerization interface 3.5A [polypeptide binding]; other site 568708010959 active site 568708010961 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 568708010962 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 568708010965 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 568708010966 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 568708010967 ligand binding site [chemical binding]; other site 568708010968 NAD binding site [chemical binding]; other site 568708010969 catalytic site [active] 568708010970 homodimer interface [polypeptide binding]; other site 568708010973 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 568708010974 1 probable transmembrane helix predicted for STM_MW23931 by TMHMM2.0 at aa 310-332 568708010975 putative transporter; Provisional; Region: PRK12382 568708010976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708010977 putative substrate translocation pore; other site 568708010978 12 probable transmembrane helices predicted for STM_MW23941 by TMHMM2.0 at aa 20-42, 52-71, 83-105, 120-142, 149-171, 176-198, 210-232, 247-269, 276-298, 303-325, 338-360 and 370-389 568708010980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708010981 non-specific DNA binding site [nucleotide binding]; other site 568708010982 salt bridge; other site 568708010983 sequence-specific DNA binding site [nucleotide binding]; other site 568708010985 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 568708010986 Signal peptide predicted for STM_MW23981 by SignalP 2.0 HMM (Signal peptide probability 0.967) with cleavage site probability 0.546 between residues 24 and 25 568708010987 CAAX protease self-immunity; Region: Abi; pfam02517 568708010988 7 probable transmembrane helices predicted for STM_MW23991 by TMHMM2.0 at aa 12-31, 41-63, 75-97, 117-139, 146-163, 168-187 and 194-216 568708010990 Signal peptide predicted for STM_MW23991 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.858 between residues 36 and 37 568708010991 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 568708010992 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 568708010993 dimer interface [polypeptide binding]; other site 568708010994 active site 568708010997 Uncharacterized conserved protein [Function unknown]; Region: COG4121 568708010998 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 568708011001 YfcL protein; Region: YfcL; pfam08891 568708011003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 568708011005 hypothetical protein; Provisional; Region: PRK10621 568708011006 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568708011007 8 probable transmembrane helices predicted for STM_MW24041 by TMHMM2.0 at aa 7-28, 32-54, 85-104, 108-127, 139-158, 163-182, 195-217 and 237-255 568708011009 Signal peptide predicted for STM_MW24041 by SignalP 2.0 HMM (Signal peptide probability 0.847) with cleavage site probability 0.756 between residues 25 and 26 568708011010 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 568708011011 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 568708011013 Signal peptide predicted for STM_MW24051 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 19 and 20 568708011014 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 568708011015 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 568708011016 Tetramer interface [polypeptide binding]; other site 568708011017 active site 568708011018 FMN-binding site [chemical binding]; other site 568708011020 HemK family putative methylases; Region: hemK_fam; TIGR00536 568708011021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708011022 S-adenosylmethionine binding site [chemical binding]; other site 568708011024 hypothetical protein; Provisional; Region: PRK04946 568708011025 Smr domain; Region: Smr; pfam01713 568708011027 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568708011028 catalytic core [active] 568708011030 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 568708011031 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568708011032 substrate binding site [chemical binding]; other site 568708011033 oxyanion hole (OAH) forming residues; other site 568708011034 trimer interface [polypeptide binding]; other site 568708011035 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568708011036 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568708011040 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 568708011041 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568708011042 dimer interface [polypeptide binding]; other site 568708011043 active site 568708011046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 568708011048 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 568708011049 Signal peptide predicted for STM_MW24131 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 27 and 28 568708011051 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 568708011053 Signal peptide predicted for STM_MW24141 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.383 between residues 21 and 22 568708011054 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 568708011056 6 probable transmembrane helices predicted for STM_MW24151 by TMHMM2.0 at aa 62-84, 94-116, 137-159, 190-209, 216-235 and 255-277 568708011057 outer membrane protease; Reviewed; Region: PRK10993 568708011059 Signal peptide predicted for STM_MW24161 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 568708011060 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 568708011061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708011062 active site 568708011063 phosphorylation site [posttranslational modification] 568708011064 intermolecular recognition site; other site 568708011065 dimerization interface [polypeptide binding]; other site 568708011066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 568708011067 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568708011071 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 568708011072 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 568708011073 dimerization interface [polypeptide binding]; other site 568708011074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708011075 dimer interface [polypeptide binding]; other site 568708011076 phosphorylation site [posttranslational modification] 568708011077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708011078 ATP binding site [chemical binding]; other site 568708011079 Mg2+ binding site [ion binding]; other site 568708011080 G-X-G motif; other site 568708011081 2 probable transmembrane helices predicted for STM_MW24181 by TMHMM2.0 at aa 20-39 and 335-357 568708011084 Signal peptide predicted for STM_MW24181 by SignalP 2.0 HMM (Signal peptide probability 0.869) with cleavage site probability 0.640 between residues 39 and 40 568708011085 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568708011086 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568708011088 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 568708011089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708011090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708011091 12 probable transmembrane helices predicted for STM_MW24201 by TMHMM2.0 at aa 21-43, 63-85, 98-120, 124-146, 158-180, 190-207, 260-282, 297-315, 327-344, 348-370, 377-399 and 414-436 568708011093 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 568708011095 3 probable transmembrane helices predicted for STM_MW24231 by TMHMM2.0 at aa 2-24, 29-48 and 55-77 568708011096 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 568708011097 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 568708011098 putative acyl-acceptor binding pocket; other site 568708011100 1 probable transmembrane helix predicted for STM_MW24241 by TMHMM2.0 at aa 20-42 568708011101 aminotransferase; Validated; Region: PRK08175 568708011102 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568708011103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708011104 homodimer interface [polypeptide binding]; other site 568708011105 catalytic residue [active] 568708011107 glucokinase; Provisional; Region: glk; PRK00292 568708011108 glucokinase, proteobacterial type; Region: glk; TIGR00749 568708011110 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 568708011111 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 568708011112 Cl- selectivity filter; other site 568708011113 Cl- binding residues [ion binding]; other site 568708011114 pore gating glutamate residue; other site 568708011115 dimer interface [polypeptide binding]; other site 568708011116 Signal peptide predicted for STM_MW24281 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.898 between residues 29 and 30 568708011117 11 probable transmembrane helices predicted for STM_MW24281 by TMHMM2.0 at aa 9-31, 57-74, 95-117, 148-170, 186-208, 223-245, 258-280, 295-317, 322-341, 345-363 and 376-398 568708011119 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 568708011120 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 568708011121 dimer interface [polypeptide binding]; other site 568708011122 PYR/PP interface [polypeptide binding]; other site 568708011123 TPP binding site [chemical binding]; other site 568708011124 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568708011125 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 568708011126 TPP-binding site [chemical binding]; other site 568708011127 dimer interface [polypeptide binding]; other site 568708011131 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568708011132 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568708011133 active site 568708011134 catalytic tetrad [active] 568708011136 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 568708011137 Signal peptide predicted for STM_MW24311 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 21 and 22 568708011139 manganese transport protein MntH; Reviewed; Region: PRK00701 568708011140 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 568708011141 11 probable transmembrane helices predicted for STM_MW24321 by TMHMM2.0 at aa 17-39, 54-76, 96-118, 123-145, 157-176, 196-218, 239-261, 281-303, 324-343, 348-370 and 390-412 568708011143 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 568708011144 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 568708011145 Nucleoside recognition; Region: Gate; pfam07670 568708011146 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 568708011147 Signal peptide predicted for STM_MW24331 by SignalP 2.0 HMM (Signal peptide probability 0.620) with cleavage site probability 0.416 between residues 23 and 24 568708011148 8 probable transmembrane helices predicted for STM_MW24331 by TMHMM2.0 at aa 4-23, 30-48, 86-108, 194-216, 249-271, 278-300, 342-364 and 377-399 568708011152 MASE1; Region: MASE1; pfam05231 568708011153 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568708011154 diguanylate cyclase; Region: GGDEF; smart00267 568708011155 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708011158 8 probable transmembrane helices predicted for STM_MW24341 by TMHMM2.0 at aa 10-32, 39-61, 86-108, 121-143, 163-185, 214-236, 246-268 and 289-311 568708011160 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 568708011162 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 568708011164 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 568708011165 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568708011166 active site 568708011167 HIGH motif; other site 568708011168 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568708011169 active site 568708011170 KMSKS motif; other site 568708011172 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 568708011173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708011174 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 568708011175 putative dimerization interface [polypeptide binding]; other site 568708011176 putative substrate binding pocket [chemical binding]; other site 568708011179 nucleoside transporter; Region: 2A0110; TIGR00889 568708011180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708011181 putative substrate translocation pore; other site 568708011183 12 probable transmembrane helices predicted for STM_MW24391 by TMHMM2.0 at aa 12-30, 40-62, 71-90, 94-116, 128-150, 160-179, 211-233, 253-275, 282-301, 306-328, 348-370 and 380-402 568708011184 purine nucleoside phosphorylase; Provisional; Region: PRK08202 568708011186 hypothetical protein; Provisional; Region: PRK11528 568708011188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708011189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708011190 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 568708011191 putative dimerization interface [polypeptide binding]; other site 568708011194 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 568708011195 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 568708011196 Signal peptide predicted for STM_MW24441 by SignalP 2.0 HMM (Signal peptide probability 0.932) with cleavage site probability 0.870 between residues 28 and 29 568708011197 9 probable transmembrane helices predicted for STM_MW24441 by TMHMM2.0 at aa 7-24, 29-48, 69-91, 101-123, 130-152, 167-189, 202-224, 229-251 and 272-294 568708011199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 568708011200 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 568708011201 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 568708011202 nucleotide binding pocket [chemical binding]; other site 568708011203 K-X-D-G motif; other site 568708011204 catalytic site [active] 568708011205 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 568708011206 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 568708011207 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 568708011208 Dimer interface [polypeptide binding]; other site 568708011209 BRCT sequence motif; other site 568708011215 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 568708011216 cell division protein ZipA; Provisional; Region: PRK03427 568708011217 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 568708011218 FtsZ protein binding site [polypeptide binding]; other site 568708011220 1 probable transmembrane helix predicted for STM_MW24471 by TMHMM2.0 at aa 22-44 568708011221 putative sulfate transport protein CysZ; Validated; Region: PRK04949 568708011222 4 probable transmembrane helices predicted for STM_MW24481 by TMHMM2.0 at aa 31-53, 68-90, 151-173 and 220-242 568708011224 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 568708011225 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 568708011226 dimer interface [polypeptide binding]; other site 568708011227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708011228 catalytic residue [active] 568708011230 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568708011231 dimerization domain swap beta strand [polypeptide binding]; other site 568708011232 regulatory protein interface [polypeptide binding]; other site 568708011233 active site 568708011234 regulatory phosphorylation site [posttranslational modification]; other site 568708011236 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 568708011237 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 568708011238 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568708011239 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568708011243 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 568708011244 HPr interaction site; other site 568708011245 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568708011246 active site 568708011247 phosphorylation site [posttranslational modification] 568708011249 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 568708011250 dimer interface [polypeptide binding]; other site 568708011251 pyridoxamine kinase; Validated; Region: PRK05756 568708011252 pyridoxal binding site [chemical binding]; other site 568708011253 ATP binding site [chemical binding]; other site 568708011255 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 568708011256 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708011257 DNA-binding site [nucleotide binding]; DNA binding site 568708011258 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568708011259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708011260 homodimer interface [polypeptide binding]; other site 568708011261 catalytic residue [active] 568708011264 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 568708011265 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 568708011266 catalytic triad [active] 568708011268 hypothetical protein; Provisional; Region: PRK10318 568708011269 Signal peptide predicted for STM_MW24571 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 25 and 26 568708011270 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 568708011271 Transglycosylase; Region: Transgly; cl17702 568708011272 1 probable transmembrane helix predicted for STM_MW24581 by TMHMM2.0 at aa 7-29 568708011274 cysteine synthase B; Region: cysM; TIGR01138 568708011275 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 568708011276 dimer interface [polypeptide binding]; other site 568708011277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708011278 catalytic residue [active] 568708011280 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 568708011281 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 568708011282 Walker A/P-loop; other site 568708011283 ATP binding site [chemical binding]; other site 568708011284 Q-loop/lid; other site 568708011285 ABC transporter signature motif; other site 568708011286 Walker B; other site 568708011287 D-loop; other site 568708011288 H-loop/switch region; other site 568708011289 TOBE-like domain; Region: TOBE_3; pfam12857 568708011291 sulfate transport protein; Provisional; Region: cysT; CHL00187 568708011292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708011293 dimer interface [polypeptide binding]; other site 568708011294 conserved gate region; other site 568708011295 putative PBP binding loops; other site 568708011296 ABC-ATPase subunit interface; other site 568708011297 6 probable transmembrane helices predicted for STM_MW24611 by TMHMM2.0 at aa 21-43, 66-88, 101-123, 143-162, 201-223 and 246-268 568708011299 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 568708011300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708011301 dimer interface [polypeptide binding]; other site 568708011302 conserved gate region; other site 568708011303 putative PBP binding loops; other site 568708011304 ABC-ATPase subunit interface; other site 568708011305 7 probable transmembrane helices predicted for STM_MW24621 by TMHMM2.0 at aa 15-37, 62-84, 104-126, 138-160, 188-205, 212-234 and 244-266 568708011307 Signal peptide predicted for STM_MW24621 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.461 between residues 45 and 46 568708011308 thiosulfate transporter subunit; Provisional; Region: PRK10852 568708011309 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568708011311 Signal peptide predicted for STM_MW24631 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 25 and 26 568708011312 short chain dehydrogenase; Provisional; Region: PRK08226 568708011313 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 568708011314 NAD binding site [chemical binding]; other site 568708011315 homotetramer interface [polypeptide binding]; other site 568708011316 homodimer interface [polypeptide binding]; other site 568708011317 active site 568708011319 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 568708011321 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 568708011322 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 568708011324 Signal peptide predicted for STM_MW24661 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.566 between residues 27 and 28 568708011325 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 568708011327 4 probable transmembrane helices predicted for STM_MW24671 by TMHMM2.0 at aa 19-41, 61-78, 90-112 and 116-135 568708011328 putative acetyltransferase; Provisional; Region: PRK03624 568708011329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708011330 Coenzyme A binding pocket [chemical binding]; other site 568708011332 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 568708011333 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 568708011334 active site 568708011335 metal binding site [ion binding]; metal-binding site 568708011336 Signal peptide predicted for STM_MW24691 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.900 between residues 34 and 35 568708011338 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 568708011339 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 568708011341 3 probable transmembrane helices predicted for STM_MW24711 by TMHMM2.0 at aa 19-36, 51-73 and 86-108 568708011342 transcriptional regulator EutR; Provisional; Region: PRK10130 568708011343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708011344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708011346 carboxysome structural protein EutK; Provisional; Region: PRK15466 568708011347 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 568708011348 Hexamer interface [polypeptide binding]; other site 568708011349 Hexagonal pore residue; other site 568708011352 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 568708011353 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 568708011354 putative hexamer interface [polypeptide binding]; other site 568708011355 putative hexagonal pore; other site 568708011356 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 568708011357 putative hexamer interface [polypeptide binding]; other site 568708011358 putative hexagonal pore; other site 568708011360 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 568708011362 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 568708011363 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 568708011365 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 568708011367 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 568708011369 10 probable transmembrane helices predicted for STM_MW24791 by TMHMM2.0 at aa 7-29, 58-80, 87-109, 124-146, 153-175, 190-212, 231-253, 273-295, 308-330 and 370-392 568708011370 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 568708011371 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 568708011372 active site 568708011373 metal binding site [ion binding]; metal-binding site 568708011375 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 568708011376 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568708011377 nucleotide binding site [chemical binding]; other site 568708011379 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 568708011380 putative catalytic cysteine [active] 568708011382 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 568708011383 Hexamer/Pentamer interface [polypeptide binding]; other site 568708011384 central pore; other site 568708011386 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 568708011387 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 568708011388 Hexamer interface [polypeptide binding]; other site 568708011389 Putative hexagonal pore residue; other site 568708011391 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 568708011393 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 568708011395 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 568708011396 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 568708011398 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 568708011399 G1 box; other site 568708011400 GTP/Mg2+ binding site [chemical binding]; other site 568708011401 G2 box; other site 568708011402 Switch I region; other site 568708011403 G3 box; other site 568708011404 Switch II region; other site 568708011405 G4 box; other site 568708011406 G5 box; other site 568708011408 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 568708011409 putative hexamer interface [polypeptide binding]; other site 568708011410 putative hexagonal pore; other site 568708011412 Transposase IS200 like; Region: Y1_Tnp; pfam01797 568708011414 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 568708011415 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568708011416 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 568708011417 putative NAD(P) binding site [chemical binding]; other site 568708011418 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 568708011422 transaldolase-like protein; Provisional; Region: PTZ00411 568708011423 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 568708011424 active site 568708011425 dimer interface [polypeptide binding]; other site 568708011426 catalytic residue [active] 568708011428 transketolase; Reviewed; Region: PRK12753 568708011429 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 568708011430 TPP-binding site [chemical binding]; other site 568708011431 dimer interface [polypeptide binding]; other site 568708011432 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568708011433 PYR/PP interface [polypeptide binding]; other site 568708011434 dimer interface [polypeptide binding]; other site 568708011435 TPP binding site [chemical binding]; other site 568708011436 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568708011440 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 568708011442 1 probable transmembrane helix predicted for STM_MW24951 by TMHMM2.0 at aa 5-24 568708011443 Signal peptide predicted for STM_MW24951 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 21 and 22 568708011444 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 568708011445 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 568708011446 dimer interface [polypeptide binding]; other site 568708011447 ADP-ribose binding site [chemical binding]; other site 568708011448 active site 568708011449 nudix motif; other site 568708011450 metal binding site [ion binding]; metal-binding site 568708011452 putative periplasmic esterase; Provisional; Region: PRK03642 568708011453 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568708011454 Signal peptide predicted for STM_MW24971 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 568708011456 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 568708011457 4Fe-4S binding domain; Region: Fer4; pfam00037 568708011458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568708011459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568708011462 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 568708011463 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 568708011464 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708011465 dimerization interface [polypeptide binding]; other site 568708011466 Histidine kinase; Region: HisKA_3; pfam07730 568708011467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708011468 ATP binding site [chemical binding]; other site 568708011469 Mg2+ binding site [ion binding]; other site 568708011470 G-X-G motif; other site 568708011471 Signal peptide predicted for STM_MW24991 by SignalP 2.0 HMM (Signal peptide probability 0.901) with cleavage site probability 0.731 between residues 40 and 41 568708011472 2 probable transmembrane helices predicted for STM_MW24991 by TMHMM2.0 at aa 15-37 and 147-169 568708011476 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 568708011477 Protein export membrane protein; Region: SecD_SecF; cl14618 568708011478 Signal peptide predicted for STM_MW25001 by SignalP 2.0 HMM (Signal peptide probability 0.914) with cleavage site probability 0.584 between residues 34 and 35 568708011480 11 probable transmembrane helices predicted for STM_MW25001 by TMHMM2.0 at aa 10-32, 337-359, 364-386, 438-460, 470-492, 538-560, 868-890, 897-919, 924-946, 972-994 and 1004-1026 568708011481 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 568708011482 ArsC family; Region: ArsC; pfam03960 568708011483 putative catalytic residues [active] 568708011485 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 568708011486 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 568708011487 metal binding site [ion binding]; metal-binding site 568708011488 dimer interface [polypeptide binding]; other site 568708011491 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 568708011492 Helicase; Region: Helicase_RecD; pfam05127 568708011493 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 568708011494 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 568708011498 Predicted metalloprotease [General function prediction only]; Region: COG2321 568708011499 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 568708011501 1 probable transmembrane helix predicted for STM_MW25041 by TMHMM2.0 at aa 38-60 568708011502 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 568708011503 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 568708011504 ATP binding site [chemical binding]; other site 568708011505 active site 568708011506 substrate binding site [chemical binding]; other site 568708011508 lipoprotein; Provisional; Region: PRK11679 568708011509 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 568708011511 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 568708011512 dihydrodipicolinate synthase; Region: dapA; TIGR00674 568708011513 dimer interface [polypeptide binding]; other site 568708011514 active site 568708011515 catalytic residue [active] 568708011517 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 568708011518 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 568708011519 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 568708011521 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 568708011522 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 568708011523 catalytic triad [active] 568708011525 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568708011526 Domain of unknown function DUF20; Region: UPF0118; pfam01594 568708011527 7 probable transmembrane helices predicted for STM_MW25101 by TMHMM2.0 at aa 25-59, 79-101, 162-184, 224-243, 258-280, 285-307 and 317-339 568708011529 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 568708011530 Peptidase family M48; Region: Peptidase_M48; cl12018 568708011531 Signal peptide predicted for STM_MW25111 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 27 and 28 568708011533 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 568708011534 ArsC family; Region: ArsC; pfam03960 568708011535 catalytic residues [active] 568708011537 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 568708011538 DNA replication initiation factor; Provisional; Region: PRK08084 568708011540 uracil transporter; Provisional; Region: PRK10720 568708011542 12 probable transmembrane helices predicted for STM_MW25141 by TMHMM2.0 at aa 13-35, 39-61, 68-85, 89-108, 121-143, 158-180, 185-207, 227-249, 304-326, 331-353, 365-387 and 392-411 568708011543 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568708011544 active site 568708011546 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 568708011547 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 568708011548 dimerization interface [polypeptide binding]; other site 568708011549 putative ATP binding site [chemical binding]; other site 568708011552 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 568708011553 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 568708011554 active site 568708011555 substrate binding site [chemical binding]; other site 568708011556 cosubstrate binding site; other site 568708011557 catalytic site [active] 568708011559 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 568708011560 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 568708011561 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 568708011562 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 568708011563 putative active site [active] 568708011564 catalytic site [active] 568708011565 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 568708011566 domain interface [polypeptide binding]; other site 568708011567 active site 568708011568 catalytic site [active] 568708011570 exopolyphosphatase; Provisional; Region: PRK10854 568708011571 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568708011572 nucleotide binding site [chemical binding]; other site 568708011574 MASE1; Region: MASE1; pfam05231 568708011575 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568708011576 diguanylate cyclase; Region: GGDEF; smart00267 568708011577 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708011579 8 probable transmembrane helices predicted for STM_MW25201 by TMHMM2.0 at aa 15-37, 44-66, 81-103, 124-146, 166-188, 216-238, 253-275 and 295-317 568708011581 Signal peptide predicted for STM_MW25201 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.653 between residues 36 and 37 568708011582 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 568708011584 Integrase core domain; Region: rve; pfam00665 568708011586 GMP synthase; Reviewed; Region: guaA; PRK00074 568708011587 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 568708011588 AMP/PPi binding site [chemical binding]; other site 568708011589 candidate oxyanion hole; other site 568708011590 catalytic triad [active] 568708011591 potential glutamine specificity residues [chemical binding]; other site 568708011592 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 568708011593 ATP Binding subdomain [chemical binding]; other site 568708011594 Ligand Binding sites [chemical binding]; other site 568708011595 Dimerization subdomain; other site 568708011599 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 568708011600 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 568708011601 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 568708011602 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 568708011603 active site 568708011606 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 568708011607 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 568708011608 generic binding surface II; other site 568708011609 generic binding surface I; other site 568708011612 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 568708011613 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568708011614 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568708011615 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 568708011616 Autotransporter beta-domain; Region: Autotransporter; smart00869 568708011618 pfam_scan;Pfam:PF05688; E()=9.7E-20;score=69.3;query209-255;description=DUF824; pfam_scan;Pfam:PF05689; E()=6.9E-52;score=175.2;query 278-459;description=DUF823; tmhmm; query 1-2434 568708011621 outer membrane protein RatA; Provisional; Region: PRK15315 568708011622 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 568708011623 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 568708011624 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 568708011625 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 568708011626 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 568708011627 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 568708011628 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 568708011629 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 568708011630 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 568708011631 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 568708011632 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 568708011635 1 probable transmembrane helix predicted for STM_MW25321 by TMHMM2.0 at aa 13-32 568708011636 Signal peptide predicted for STM_MW25321 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.905 between residues 30 and 31 568708011637 intimin-like protein SinH; Provisional; Region: PRK15318 568708011638 1 probable transmembrane helix predicted for STM_MW25331 by TMHMM2.0 at aa 12-29 568708011639 Signal peptide predicted for STM_MW25331 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.951 between residues 28 and 29 568708011640 intimin-like protein SinH; Provisional; Region: PRK15318 568708011641 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 568708011642 Signal peptide predicted for STM_MW25341 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.828 between residues 22 and 23 568708011643 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 568708011645 GTP-binding protein Der; Reviewed; Region: PRK00093 568708011646 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 568708011647 G1 box; other site 568708011648 GTP/Mg2+ binding site [chemical binding]; other site 568708011649 Switch I region; other site 568708011650 G2 box; other site 568708011651 Switch II region; other site 568708011652 G3 box; other site 568708011653 G4 box; other site 568708011654 G5 box; other site 568708011655 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 568708011656 G1 box; other site 568708011657 GTP/Mg2+ binding site [chemical binding]; other site 568708011658 Switch I region; other site 568708011659 G2 box; other site 568708011660 G3 box; other site 568708011661 Switch II region; other site 568708011662 G4 box; other site 568708011663 G5 box; other site 568708011666 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 568708011667 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 568708011668 Trp docking motif [polypeptide binding]; other site 568708011669 active site 568708011671 Signal peptide predicted for STM_MW25371 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.942 between residues 24 and 25 568708011672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 568708011673 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 568708011675 1 probable transmembrane helix predicted for STM_MW25381 by TMHMM2.0 at aa 21-43 568708011676 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 568708011677 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 568708011678 dimer interface [polypeptide binding]; other site 568708011679 motif 1; other site 568708011680 active site 568708011681 motif 2; other site 568708011682 motif 3; other site 568708011683 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 568708011684 anticodon binding site; other site 568708011687 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 568708011688 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 568708011689 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 568708011691 cytoskeletal protein RodZ; Provisional; Region: PRK10856 568708011692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708011693 non-specific DNA binding site [nucleotide binding]; other site 568708011694 salt bridge; other site 568708011695 sequence-specific DNA binding site [nucleotide binding]; other site 568708011696 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 568708011698 1 probable transmembrane helix predicted for STM_MW25411 by TMHMM2.0 at aa 111-133 568708011699 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 568708011700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708011701 FeS/SAM binding site; other site 568708011703 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 568708011704 active site 568708011705 multimer interface [polypeptide binding]; other site 568708011707 4Fe-4S binding domain; Region: Fer4; pfam00037 568708011708 hydrogenase 4 subunit H; Validated; Region: PRK08222 568708011710 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 568708011712 8 probable transmembrane helices predicted for STM_MW25451 by TMHMM2.0 at aa 4-26, 47-69, 84-103, 110-132, 142-164, 171-193, 221-240 and 247-266 568708011713 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 568708011714 4Fe-4S binding domain; Region: Fer4; pfam00037 568708011716 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 568708011717 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 568708011718 putative [Fe4-S4] binding site [ion binding]; other site 568708011719 putative molybdopterin cofactor binding site [chemical binding]; other site 568708011720 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 568708011721 putative molybdopterin cofactor binding site; other site 568708011725 Signal peptide predicted for STM_MW25471 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.650 between residues 48 and 49 568708011726 penicillin-binding protein 1C; Provisional; Region: PRK11240 568708011727 Transglycosylase; Region: Transgly; pfam00912 568708011728 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 568708011729 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 568708011733 1 probable transmembrane helix predicted for STM_MW25481 by TMHMM2.0 at aa 9-28 568708011734 Signal peptide predicted for STM_MW25481 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.996 between residues 27 and 28 568708011735 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 568708011736 MG2 domain; Region: A2M_N; pfam01835 568708011737 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 568708011738 surface patch; other site 568708011739 thioester region; other site 568708011740 specificity defining residues; other site 568708011743 Signal peptide predicted for STM_MW25491 by SignalP 2.0 HMM (Signal peptide probability 0.715) with cleavage site probability 0.464 between residues 21 and 22 568708011744 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 568708011745 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 568708011746 active site residue [active] 568708011747 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 568708011748 active site residue [active] 568708011750 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 568708011752 aminopeptidase B; Provisional; Region: PRK05015 568708011753 Peptidase; Region: DUF3663; pfam12404 568708011754 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 568708011755 interface (dimer of trimers) [polypeptide binding]; other site 568708011756 Substrate-binding/catalytic site; other site 568708011757 Zn-binding sites [ion binding]; other site 568708011759 hypothetical protein; Provisional; Region: PRK10721 568708011761 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568708011762 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568708011763 catalytic loop [active] 568708011764 iron binding site [ion binding]; other site 568708011766 chaperone protein HscA; Provisional; Region: hscA; PRK05183 568708011767 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 568708011768 nucleotide binding site [chemical binding]; other site 568708011769 putative NEF/HSP70 interaction site [polypeptide binding]; other site 568708011770 SBD interface [polypeptide binding]; other site 568708011772 co-chaperone HscB; Provisional; Region: hscB; PRK05014 568708011773 DnaJ domain; Region: DnaJ; pfam00226 568708011774 HSP70 interaction site [polypeptide binding]; other site 568708011775 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 568708011778 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 568708011780 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 568708011781 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 568708011782 trimerization site [polypeptide binding]; other site 568708011783 active site 568708011785 cysteine desulfurase; Provisional; Region: PRK14012 568708011786 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 568708011787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568708011788 catalytic residue [active] 568708011790 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 568708011791 Rrf2 family protein; Region: rrf2_super; TIGR00738 568708011793 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 568708011794 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 568708011796 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568708011797 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 568708011798 active site 568708011799 dimerization interface [polypeptide binding]; other site 568708011801 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 568708011802 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568708011803 1 probable transmembrane helix predicted for STM_MW25641 by TMHMM2.0 at aa 13-35 568708011805 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 568708011806 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 568708011807 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 568708011808 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 568708011809 FAD binding pocket [chemical binding]; other site 568708011810 FAD binding motif [chemical binding]; other site 568708011811 phosphate binding motif [ion binding]; other site 568708011812 beta-alpha-beta structure motif; other site 568708011813 NAD binding pocket [chemical binding]; other site 568708011814 Iron coordination center [ion binding]; other site 568708011818 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 568708011819 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 568708011820 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 568708011824 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 568708011825 7 probable transmembrane helices predicted for STM_MW25681 by TMHMM2.0 at aa 13-35, 75-97, 110-132, 147-169, 225-247, 251-273 and 294-316 568708011827 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 568708011829 1 probable transmembrane helix predicted for STM_MW25691 by TMHMM2.0 at aa 7-24 568708011830 Signal peptide predicted for STM_MW25691 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.957 between residues 22 and 23 568708011831 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 568708011832 PRD domain; Region: PRD; pfam00874 568708011833 PRD domain; Region: PRD; pfam00874 568708011835 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 568708011836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708011837 putative substrate translocation pore; other site 568708011839 12 probable transmembrane helices predicted for STM_MW25711 by TMHMM2.0 at aa 9-31, 41-63, 70-89, 93-111, 132-154, 158-180, 207-229, 234-256, 269-288, 293-315, 328-350 and 354-371 568708011840 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 568708011841 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 568708011842 dimer interface [polypeptide binding]; other site 568708011843 active site 568708011844 glycine-pyridoxal phosphate binding site [chemical binding]; other site 568708011845 folate binding site [chemical binding]; other site 568708011847 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 568708011848 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 568708011849 heme-binding site [chemical binding]; other site 568708011850 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 568708011851 FAD binding pocket [chemical binding]; other site 568708011852 FAD binding motif [chemical binding]; other site 568708011853 phosphate binding motif [ion binding]; other site 568708011854 beta-alpha-beta structure motif; other site 568708011855 NAD binding pocket [chemical binding]; other site 568708011856 Heme binding pocket [chemical binding]; other site 568708011860 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 568708011861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708011862 DNA binding site [nucleotide binding] 568708011864 1 probable transmembrane helix predicted for STM_MW25741 by TMHMM2.0 at aa 162-184 568708011865 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 568708011866 Signal peptide predicted for STM_MW25751 by SignalP 2.0 HMM (Signal peptide probability 0.857) with cleavage site probability 0.420 between residues 26 and 27 568708011867 12 probable transmembrane helices predicted for STM_MW25751 by TMHMM2.0 at aa 7-29, 39-58, 93-115, 120-142, 149-171, 186-208, 220-242, 265-287, 322-344, 354-371, 384-403 and 407-424 568708011869 lysine decarboxylase CadA; Provisional; Region: PRK15400 568708011870 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 568708011871 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 568708011872 homodimer interface [polypeptide binding]; other site 568708011873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708011874 catalytic residue [active] 568708011875 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 568708011879 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 568708011880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708011881 putative substrate translocation pore; other site 568708011882 POT family; Region: PTR2; pfam00854 568708011883 14 probable transmembrane helices predicted for STM_MW25771 by TMHMM2.0 at aa 9-31, 46-68, 71-93, 103-125, 138-160, 164-186, 207-229, 234-251, 264-281, 307-329, 341-363, 373-395, 407-429 and 449-471 568708011885 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 568708011886 Nitrogen regulatory protein P-II; Region: P-II; smart00938 568708011888 response regulator GlrR; Provisional; Region: PRK15115 568708011889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708011890 active site 568708011891 phosphorylation site [posttranslational modification] 568708011892 intermolecular recognition site; other site 568708011893 dimerization interface [polypeptide binding]; other site 568708011894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708011895 Walker A motif; other site 568708011896 ATP binding site [chemical binding]; other site 568708011897 Walker B motif; other site 568708011898 arginine finger; other site 568708011901 hypothetical protein; Provisional; Region: PRK10722 568708011902 Signal peptide predicted for STM_MW25801 by SignalP 2.0 HMM (Signal peptide probability 0.780) with cleavage site probability 0.716 between residues 41 and 42 568708011903 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568708011904 HAMP domain; Region: HAMP; pfam00672 568708011905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708011906 dimer interface [polypeptide binding]; other site 568708011907 phosphorylation site [posttranslational modification] 568708011908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708011909 ATP binding site [chemical binding]; other site 568708011910 Mg2+ binding site [ion binding]; other site 568708011911 G-X-G motif; other site 568708011913 2 probable transmembrane helices predicted for STM_MW25811 by TMHMM2.0 at aa 15-37 and 179-201 568708011915 Signal peptide predicted for STM_MW25811 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.921 between residues 34 and 35 568708011916 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 568708011917 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 568708011918 dimerization interface [polypeptide binding]; other site 568708011919 ATP binding site [chemical binding]; other site 568708011920 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 568708011921 dimerization interface [polypeptide binding]; other site 568708011922 ATP binding site [chemical binding]; other site 568708011923 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 568708011924 putative active site [active] 568708011925 catalytic triad [active] 568708011928 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 568708011929 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568708011930 substrate binding pocket [chemical binding]; other site 568708011931 membrane-bound complex binding site; other site 568708011932 hinge residues; other site 568708011933 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568708011934 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568708011935 catalytic residue [active] 568708011936 Signal peptide predicted for STM_MW25831 by SignalP 2.0 HMM (Signal peptide probability 0.941) with cleavage site probability 0.504 between residues 21 and 22 568708011937 1 probable transmembrane helix predicted for STM_MW25831 by TMHMM2.0 at aa 7-29 568708011940 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 568708011941 nucleoside/Zn binding site; other site 568708011942 dimer interface [polypeptide binding]; other site 568708011943 catalytic motif [active] 568708011945 hypothetical protein; Provisional; Region: PRK11590 568708011946 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 568708011947 1 probable transmembrane helix predicted for STM_MW25851 by TMHMM2.0 at aa 35-54 568708011948 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 568708011949 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568708011950 active site turn [active] 568708011951 phosphorylation site [posttranslational modification] 568708011952 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568708011953 9 probable transmembrane helices predicted for STM_MW25861 by TMHMM2.0 at aa 116-138, 153-175, 182-204, 214-231, 287-309, 324-346, 359-381, 396-418 and 425-447 568708011956 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 568708011957 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 568708011958 putative active site [active] 568708011960 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568708011961 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 568708011962 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568708011963 putative active site [active] 568708011966 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 568708011967 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 568708011968 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 568708011971 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 568708011972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708011973 putative substrate translocation pore; other site 568708011974 12 probable transmembrane helices predicted for STM_MW25901 by TMHMM2.0 at aa 10-29, 42-64, 74-93, 98-115, 130-152, 165-184, 213-235, 242-264, 274-296, 301-323, 338-357 and 364-386 568708011976 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708011977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708011978 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568708011979 dimerization interface [polypeptide binding]; other site 568708011982 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 568708011984 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 568708011986 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 568708011987 active site 568708011988 hydrophilic channel; other site 568708011989 dimerization interface [polypeptide binding]; other site 568708011990 catalytic residues [active] 568708011991 active site lid [active] 568708011993 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 568708011994 Recombination protein O N terminal; Region: RecO_N; pfam11967 568708011995 Recombination protein O C terminal; Region: RecO_C; pfam02565 568708011997 GTPase Era; Reviewed; Region: era; PRK00089 568708011998 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 568708011999 G1 box; other site 568708012000 GTP/Mg2+ binding site [chemical binding]; other site 568708012001 Switch I region; other site 568708012002 G2 box; other site 568708012003 Switch II region; other site 568708012004 G3 box; other site 568708012005 G4 box; other site 568708012006 G5 box; other site 568708012007 KH domain; Region: KH_2; pfam07650 568708012011 ribonuclease III; Reviewed; Region: rnc; PRK00102 568708012012 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 568708012013 dimerization interface [polypeptide binding]; other site 568708012014 active site 568708012015 metal binding site [ion binding]; metal-binding site 568708012016 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 568708012017 dsRNA binding site [nucleotide binding]; other site 568708012020 signal peptidase I; Provisional; Region: PRK10861 568708012021 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568708012022 Catalytic site [active] 568708012023 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568708012025 2 probable transmembrane helices predicted for STM_MW25981 by TMHMM2.0 at aa 5-27 and 60-82 568708012027 GTP-binding protein LepA; Provisional; Region: PRK05433 568708012028 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 568708012029 G1 box; other site 568708012030 putative GEF interaction site [polypeptide binding]; other site 568708012031 GTP/Mg2+ binding site [chemical binding]; other site 568708012032 Switch I region; other site 568708012033 G2 box; other site 568708012034 G3 box; other site 568708012035 Switch II region; other site 568708012036 G4 box; other site 568708012037 G5 box; other site 568708012038 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 568708012039 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 568708012040 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 568708012045 BTP4 568708012046 type III secretion protein GogB; Provisional; Region: PRK15386 568708012047 1 probable transmembrane helix predicted for STM_MW26011 by TMHMM2.0 at aa 4-26 568708012048 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 568708012049 DNA-binding interface [nucleotide binding]; DNA binding site 568708012051 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 568708012053 Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900 568708012054 ADP-ribose binding site [chemical binding]; other site 568708012055 putative active site [active] 568708012056 dimer interface [polypeptide binding]; other site 568708012058 Signal peptide predicted for STM_MW26071 by SignalP 2.0 HMM (Signal peptide probability 0.769) with cleavage site probability 0.442 between residues 18 and 19 568708012059 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 568708012060 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 568708012061 Phage Tail Collar Domain; Region: Collar; pfam07484 568708012065 Signal peptide predicted for STM_MW26071 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.978 between residues 25 and 26 568708012066 Phage-related protein, tail component [Function unknown]; Region: COG4733 568708012067 Putative phage tail protein; Region: Phage-tail_3; pfam13550 568708012068 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 568708012069 Interdomain contacts; other site 568708012070 Cytokine receptor motif; other site 568708012071 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 568708012072 Fibronectin type III protein; Region: DUF3672; pfam12421 568708012074 Phage-related protein, tail component [Function unknown]; Region: COG4723 568708012076 2 probable transmembrane helices predicted for STM_MW26101 by TMHMM2.0 at aa 100-117 and 122-144 568708012077 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 568708012078 MPN+ (JAMM) motif; other site 568708012079 Zinc-binding site [ion binding]; other site 568708012080 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 568708012081 NlpC/P60 family; Region: NLPC_P60; cl17555 568708012083 Phage-related protein [Function unknown]; Region: gp18; COG4672 568708012085 Phage-related protein [Function unknown]; Region: COG4718 568708012087 Phage-related minor tail protein [Function unknown]; Region: COG5281 568708012088 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 568708012089 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 568708012092 Minor tail protein T; Region: Phage_tail_T; pfam06223 568708012094 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 568708012096 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 568708012097 Phage tail protein; Region: Phage_tail_3; pfam08813 568708012099 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 568708012101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 568708012102 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 568708012103 Probable transposase; Region: OrfB_IS605; pfam01385 568708012104 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 568708012107 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 568708012109 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 568708012111 DNA packaging protein FI; Region: Packaging_FI; pfam14000 568708012112 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 568708012114 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 568708012116 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 568708012117 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 568708012118 tandem repeat interface [polypeptide binding]; other site 568708012119 oligomer interface [polypeptide binding]; other site 568708012120 active site residues [active] 568708012122 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 568708012123 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 568708012125 gpW; Region: gpW; pfam02831 568708012127 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 568708012129 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 568708012131 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 568708012132 Signal peptide predicted for STM_MW26301 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.945 between residues 24 and 25 568708012134 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 568708012136 Signal peptide predicted for STM_MW26311 by SignalP 2.0 HMM (Signal peptide probability 0.934) with cleavage site probability 0.701 between residues 24 and 25 568708012137 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 568708012138 catalytic residues [active] 568708012140 phage holin, lambda family; Region: holin_lambda; TIGR01594 568708012142 2 probable transmembrane helices predicted for STM_MW26322 by TMHMM2.0 at aa 21-43 and 70-92 568708012143 PipA protein; Region: PipA; pfam07108 568708012145 ORF6N domain; Region: ORF6N; pfam10543 568708012147 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 568708012149 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 568708012151 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 568708012153 cggtaggcatcgaatgatttac; Pr21F 568708012154 gtcagaagatagctggtatgac; Pr21R 568708012155 DinI-like family; Region: DinI; pfam06183 568708012157 1 probable transmembrane helix predicted for STM_MW26411 by TMHMM2.0 at aa 170-189 568708012158 Protein of unknown function (DUF550); Region: DUF550; pfam04447 568708012160 Replication protein P; Region: Phage_lambda_P; pfam06992 568708012162 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 568708012164 Bacteriophage CII protein; Region: Phage_CII; pfam05269 568708012166 transcriptional repressor DicA; Reviewed; Region: PRK09706 568708012167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708012168 non-specific DNA binding site [nucleotide binding]; other site 568708012169 salt bridge; other site 568708012170 sequence-specific DNA binding site [nucleotide binding]; other site 568708012172 AAA domain; Region: AAA_31; pfam13614 568708012173 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 568708012174 P-loop; other site 568708012175 Magnesium ion binding site [ion binding]; other site 568708012176 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 568708012177 Magnesium ion binding site [ion binding]; other site 568708012180 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 568708012181 exonuclease VIII; Reviewed; Region: PRK09709 568708012182 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 568708012184 RecT family; Region: RecT; pfam03837 568708012186 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 568708012187 integrase; Provisional; Region: PRK09692 568708012188 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 568708012189 active site 568708012190 Int/Topo IB signature motif; other site 568708012192 SoxR reducing system protein RseC; Provisional; Region: PRK10862 568708012194 2 probable transmembrane helices predicted for STM_MW26571 by TMHMM2.0 at aa 78-100 and 104-121 568708012195 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 568708012196 anti-sigma E factor; Provisional; Region: rseB; PRK09455 568708012198 Signal peptide predicted for STM_MW26581 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.948 between residues 23 and 24 568708012199 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 568708012200 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 568708012201 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 568708012204 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 568708012205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568708012206 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568708012207 DNA binding residues [nucleotide binding] 568708012210 L-aspartate oxidase; Provisional; Region: PRK09077 568708012211 L-aspartate oxidase; Provisional; Region: PRK06175 568708012212 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 568708012215 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 568708012216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708012217 S-adenosylmethionine binding site [chemical binding]; other site 568708012219 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 568708012220 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568708012221 ATP binding site [chemical binding]; other site 568708012222 Mg++ binding site [ion binding]; other site 568708012223 motif III; other site 568708012224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708012225 nucleotide binding region [chemical binding]; other site 568708012226 ATP-binding site [chemical binding]; other site 568708012229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708012230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708012231 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568708012232 dimerization interface [polypeptide binding]; other site 568708012235 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 568708012236 6 probable transmembrane helices predicted for STM_MW26651 by TMHMM2.0 at aa 10-32, 44-66, 70-92, 105-127, 142-164 and 177-194 568708012238 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 568708012240 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 568708012241 ligand binding site [chemical binding]; other site 568708012242 active site 568708012243 UGI interface [polypeptide binding]; other site 568708012244 catalytic site [active] 568708012246 putative methyltransferase; Provisional; Region: PRK10864 568708012247 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 568708012248 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568708012251 thioredoxin 2; Provisional; Region: PRK10996 568708012252 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 568708012253 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568708012254 catalytic residues [active] 568708012256 Uncharacterized conserved protein [Function unknown]; Region: COG3148 568708012258 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 568708012259 CoA binding domain; Region: CoA_binding_2; pfam13380 568708012260 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 568708012261 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 568708012262 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568708012263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708012264 Coenzyme A binding pocket [chemical binding]; other site 568708012266 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 568708012267 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 568708012268 domain interface [polypeptide binding]; other site 568708012269 putative active site [active] 568708012270 catalytic site [active] 568708012271 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 568708012272 domain interface [polypeptide binding]; other site 568708012273 putative active site [active] 568708012274 catalytic site [active] 568708012276 lipoprotein; Provisional; Region: PRK10759 568708012278 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 568708012279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708012280 putative substrate translocation pore; other site 568708012281 12 probable transmembrane helices predicted for STM_MW26741 by TMHMM2.0 at aa 21-43, 63-85, 97-114, 119-141, 161-183, 198-215, 245-267, 282-304, 311-328, 338-360, 373-395 and 405-424 568708012283 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 568708012284 protein disaggregation chaperone; Provisional; Region: PRK10865 568708012285 Clp amino terminal domain; Region: Clp_N; pfam02861 568708012286 Clp amino terminal domain; Region: Clp_N; pfam02861 568708012287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708012288 Walker A motif; other site 568708012289 ATP binding site [chemical binding]; other site 568708012290 Walker B motif; other site 568708012291 arginine finger; other site 568708012292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708012293 Walker A motif; other site 568708012294 ATP binding site [chemical binding]; other site 568708012295 Walker B motif; other site 568708012296 arginine finger; other site 568708012297 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 568708012302 hypothetical protein; Provisional; Region: PRK10723 568708012303 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 568708012305 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 568708012306 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568708012307 RNA binding surface [nucleotide binding]; other site 568708012308 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568708012309 active site 568708012312 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 568708012313 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 568708012314 Signal peptide predicted for STM_MW26791 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.476 between residues 23 and 24 568708012315 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 568708012316 30S subunit binding site; other site 568708012318 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 568708012319 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 568708012320 Prephenate dehydratase; Region: PDT; pfam00800 568708012321 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 568708012322 putative L-Phe binding site [chemical binding]; other site 568708012325 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 568708012327 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 568708012328 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 568708012329 prephenate dehydrogenase; Validated; Region: PRK08507 568708012332 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 568708012333 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 568708012335 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 568708012336 Signal peptide predicted for STM_MW26851 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23 568708012337 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 568708012338 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568708012339 metal binding site [ion binding]; metal-binding site 568708012340 active site 568708012341 I-site; other site 568708012342 Signal peptide predicted for STM_MW26861 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.512 between residues 38 and 39 568708012343 2 probable transmembrane helices predicted for STM_MW26861 by TMHMM2.0 at aa 21-43 and 153-175 568708012345 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 568708012347 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 568708012349 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 568708012350 RimM N-terminal domain; Region: RimM; pfam01782 568708012351 PRC-barrel domain; Region: PRC; pfam05239 568708012354 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 568708012356 signal recognition particle protein; Provisional; Region: PRK10867 568708012357 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 568708012358 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 568708012359 P loop; other site 568708012360 GTP binding site [chemical binding]; other site 568708012361 Signal peptide binding domain; Region: SRP_SPB; pfam02978 568708012365 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 568708012366 Signal peptide predicted for STM_MW26921 by SignalP 2.0 HMM (Signal peptide probability 0.764) with cleavage site probability 0.439 between residues 17 and 18 568708012367 8 probable transmembrane helices predicted for STM_MW26921 by TMHMM2.0 at aa 2-24, 34-56, 63-85, 90-109, 129-151, 176-198, 210-227 and 237-254 568708012369 hypothetical protein; Provisional; Region: PRK11573 568708012370 Domain of unknown function DUF21; Region: DUF21; pfam01595 568708012371 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568708012372 Transporter associated domain; Region: CorC_HlyC; smart01091 568708012374 3 probable transmembrane helices predicted for STM_MW26931 by TMHMM2.0 at aa 33-55, 65-83 and 95-117 568708012378 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 568708012379 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 568708012380 dimer interface [polypeptide binding]; other site 568708012381 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 568708012383 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 568708012384 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 568708012386 recombination and repair protein; Provisional; Region: PRK10869 568708012387 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 568708012388 Walker A/P-loop; other site 568708012389 ATP binding site [chemical binding]; other site 568708012390 Q-loop/lid; other site 568708012391 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 568708012392 ABC transporter signature motif; other site 568708012393 Walker B; other site 568708012394 D-loop; other site 568708012395 H-loop/switch region; other site 568708012397 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 568708012398 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 568708012399 Signal peptide predicted for STM_MW26991 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.424 between residues 22 and 23 568708012401 hypothetical protein; Validated; Region: PRK01777 568708012403 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 568708012404 putative coenzyme Q binding site [chemical binding]; other site 568708012406 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 568708012407 SmpB-tmRNA interface; other site 568708012409 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012410 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012411 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012412 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012413 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012414 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012415 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012416 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012417 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012418 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012419 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012420 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 568708012421 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012422 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012423 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 568708012424 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012425 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708012426 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 568708012427 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 568708012428 Signal peptide predicted for STM_MW27041 by SignalP 2.0 HMM (Signal peptide probability 0.774) with cleavage site probability 0.556 between residues 22 and 23 568708012430 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 568708012431 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568708012432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708012433 Walker A/P-loop; other site 568708012434 ATP binding site [chemical binding]; other site 568708012435 Q-loop/lid; other site 568708012436 ABC transporter signature motif; other site 568708012437 Walker B; other site 568708012438 D-loop; other site 568708012439 H-loop/switch region; other site 568708012440 5 probable transmembrane helices predicted for STM_MW27051 by TMHMM2.0 at aa 168-190, 205-222, 281-303, 307-324 and 389-411 568708012443 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 568708012444 HlyD family secretion protein; Region: HlyD_3; pfam13437 568708012445 1 probable transmembrane helix predicted for STM_MW27061 by TMHMM2.0 at aa 13-35 568708012447 phage insertion 568708012448 pfam_scan;Pfam:PF00589; E()=2.4E-18;score=66.3;query229- 382;description=Phage_integrase 568708012450 SEC-C motif; Region: SEC-C; pfam02810 568708012452 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 568708012454 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 568708012456 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 568708012458 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568708012459 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708012460 non-specific DNA binding site [nucleotide binding]; other site 568708012461 salt bridge; other site 568708012462 sequence-specific DNA binding site [nucleotide binding]; other site 568708012464 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 568708012465 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 568708012467 3 probable transmembrane helices predicted for STM_MW27171 by TMHMM2.0 at aa 20-42, 63-85 and 142-164 568708012468 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 568708012470 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 568708012471 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 568708012472 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 568708012474 4 probable transmembrane helices predicted for STM_MW27191 by TMHMM2.0 at aa 190-212, 219-241, 256-278 and 299-321 568708012476 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568708012477 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568708012478 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568708012481 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 568708012482 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 568708012483 active site 568708012484 dimer interface [polypeptide binding]; other site 568708012485 magnesium binding site [ion binding]; other site 568708012487 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 568708012488 tetramer interface [polypeptide binding]; other site 568708012489 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568708012490 active site 568708012492 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 568708012493 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 568708012495 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568708012496 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 568708012497 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568708012498 active site turn [active] 568708012499 phosphorylation site [posttranslational modification] 568708012501 10 probable transmembrane helices predicted for STM_MW27261 by TMHMM2.0 at aa 13-35, 61-83, 90-112, 127-149, 170-192, 271-293, 306-324, 328-350, 352-374 and 380-402 568708012503 Signal peptide predicted for STM_MW27261 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.462 between residues 38 and 39 568708012504 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 568708012505 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 568708012506 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 568708012508 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 568708012509 Integrase; Region: Integrase_1; pfam12835 568708012510 4 probable transmembrane helices predicted for STM_MW27301 by TMHMM2.0 at aa 30-52, 110-132, 145-167 and 177-199 568708012512 pfam_scan;Pfam:PF00665; E()=1.2E-19;score=70.3;query61-195;description=rve 568708012514 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 568708012515 DNA-binding interface [nucleotide binding]; DNA binding site 568708012517 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 568708012518 Family description; Region: UvrD_C_2; pfam13538 568708012519 Transposase; Region: HTH_Tnp_1; cl17663 568708012520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568708012522 putative transposase OrfB; Reviewed; Region: PHA02517 568708012523 HTH-like domain; Region: HTH_21; pfam13276 568708012524 Integrase core domain; Region: rve; pfam00665 568708012525 Integrase core domain; Region: rve_2; pfam13333 568708012527 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 568708012529 flagellin; Validated; Region: PRK08026 568708012530 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 568708012531 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 568708012532 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 568708012536 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 568708012537 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 568708012538 catalytic residues [active] 568708012539 catalytic nucleophile [active] 568708012540 Presynaptic Site I dimer interface [polypeptide binding]; other site 568708012541 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 568708012542 Synaptic Flat tetramer interface [polypeptide binding]; other site 568708012543 Synaptic Site I dimer interface [polypeptide binding]; other site 568708012544 DNA binding site [nucleotide binding] 568708012545 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 568708012546 DNA-binding interface [nucleotide binding]; DNA binding site 568708012549 1 probable transmembrane helix predicted for STM_MW27391 by TMHMM2.0 at aa 165-182 568708012550 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 568708012551 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 568708012552 homodimer interface [polypeptide binding]; other site 568708012553 active site 568708012554 TDP-binding site; other site 568708012555 acceptor substrate-binding pocket; other site 568708012558 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568708012559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708012560 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568708012561 Walker A/P-loop; other site 568708012562 ATP binding site [chemical binding]; other site 568708012563 Q-loop/lid; other site 568708012564 ABC transporter signature motif; other site 568708012565 Walker B; other site 568708012566 D-loop; other site 568708012567 H-loop/switch region; other site 568708012568 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568708012569 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568708012570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708012571 Walker A/P-loop; other site 568708012572 ATP binding site [chemical binding]; other site 568708012573 Q-loop/lid; other site 568708012574 ABC transporter signature motif; other site 568708012575 Walker B; other site 568708012576 D-loop; other site 568708012577 H-loop/switch region; other site 568708012578 11 probable transmembrane helices predicted for STM_MW27411 by TMHMM2.0 at aa 27-49, 64-83, 138-160, 165-182, 243-265, 280-302, 649-671, 686-708, 767-786, 790-809 and 871-893 568708012581 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 568708012582 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 568708012583 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 568708012585 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 568708012586 Signal peptide predicted for STM_MW27431 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 28 and 29 568708012587 1 probable transmembrane helix predicted for STM_MW27431 by TMHMM2.0 at aa 13-30 568708012589 outer membrane receptor FepA; Provisional; Region: PRK13528 568708012590 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568708012591 N-terminal plug; other site 568708012592 ligand-binding site [chemical binding]; other site 568708012595 Signal peptide predicted for STM_MW27441 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.937 between residues 25 and 26 568708012596 secreted effector protein PipB2; Provisional; Region: PRK15196 568708012597 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 568708012598 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 568708012599 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 568708012600 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 568708012601 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 568708012603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 568708012605 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 568708012606 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 568708012608 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 568708012609 7 probable transmembrane helices predicted for STM_MW27501 by TMHMM2.0 at aa 10-32, 76-98, 118-140, 176-198, 213-235, 256-278 and 306-325 568708012611 Signal peptide predicted for STM_MW27501 by SignalP 2.0 HMM (Signal peptide probability 0.871) with cleavage site probability 0.611 between residues 23 and 24 568708012612 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 568708012613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568708012614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 568708012615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708012616 dimer interface [polypeptide binding]; other site 568708012617 phosphorylation site [posttranslational modification] 568708012618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708012619 ATP binding site [chemical binding]; other site 568708012620 Mg2+ binding site [ion binding]; other site 568708012621 G-X-G motif; other site 568708012624 2 probable transmembrane helices predicted for STM_MW27511 by TMHMM2.0 at aa 15-37 and 170-192 568708012626 Signal peptide predicted for STM_MW27511 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.532 between residues 36 and 37 568708012627 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 568708012628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708012629 active site 568708012630 phosphorylation site [posttranslational modification] 568708012631 intermolecular recognition site; other site 568708012632 dimerization interface [polypeptide binding]; other site 568708012633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708012634 DNA binding site [nucleotide binding] 568708012637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568708012638 Signal peptide predicted for STM_MW27531 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23 568708012640 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 568708012641 4 probable transmembrane helices predicted for STM_MW27541 by TMHMM2.0 at aa 7-24, 39-56, 69-91 and 106-128 568708012642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 568708012644 12 probable transmembrane helices predicted for STM_MW27551 by TMHMM2.0 at aa 20-42, 47-69, 110-132, 142-164, 171-193, 208-230, 260-282, 321-343, 356-378, 388-410, 415-433 and 470-492 568708012645 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 568708012646 substrate binding pocket [chemical binding]; other site 568708012647 active site 568708012648 iron coordination sites [ion binding]; other site 568708012650 Predicted dehydrogenase [General function prediction only]; Region: COG0579 568708012651 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568708012653 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 568708012654 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 568708012655 tetramerization interface [polypeptide binding]; other site 568708012656 NAD(P) binding site [chemical binding]; other site 568708012657 catalytic residues [active] 568708012659 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 568708012660 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568708012661 inhibitor-cofactor binding pocket; inhibition site 568708012662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708012663 catalytic residue [active] 568708012665 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 568708012666 Signal peptide predicted for STM_MW27601 by SignalP 2.0 HMM (Signal peptide probability 0.617) with cleavage site probability 0.573 between residues 41 and 42 568708012668 12 probable transmembrane helices predicted for STM_MW27601 by TMHMM2.0 at aa 19-41, 46-65, 86-108, 123-145, 152-174, 202-224, 245-267, 287-309, 335-357, 362-381, 401-423 and 427-449 568708012669 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 568708012670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708012671 DNA-binding site [nucleotide binding]; DNA binding site 568708012672 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568708012675 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 568708012676 bacterial OsmY and nodulation domain; Region: BON; smart00749 568708012677 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568708012680 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 568708012682 2 probable transmembrane helices predicted for STM_MW27631 by TMHMM2.0 at aa 2-20 and 25-47 568708012683 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568708012684 dimerization interface [polypeptide binding]; other site 568708012685 putative DNA binding site [nucleotide binding]; other site 568708012686 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568708012687 putative Zn2+ binding site [ion binding]; other site 568708012689 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 568708012690 active site residue [active] 568708012691 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 568708012694 2 probable transmembrane helices predicted for STM_MW27651 by TMHMM2.0 at aa 117-139 and 143-165 568708012695 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 568708012696 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 568708012698 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 568708012700 4 probable transmembrane helices predicted for STM_MW27671 by TMHMM2.0 at aa 12-34, 44-62, 83-105 and 110-132 568708012701 hypothetical protein; Provisional; Region: PRK10556 568708012703 hypothetical protein; Provisional; Region: PRK10132 568708012705 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 568708012706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708012707 DNA-binding site [nucleotide binding]; DNA binding site 568708012708 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568708012709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708012710 homodimer interface [polypeptide binding]; other site 568708012711 catalytic residue [active] 568708012714 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 568708012715 Uncharacterized conserved protein [Function unknown]; Region: COG2128 568708012717 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 568708012718 catalytic residues [active] 568708012720 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 568708012722 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 568708012723 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 568708012724 Class I ribonucleotide reductase; Region: RNR_I; cd01679 568708012725 active site 568708012726 dimer interface [polypeptide binding]; other site 568708012727 catalytic residues [active] 568708012728 effector binding site; other site 568708012729 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 568708012733 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 568708012734 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 568708012735 dimer interface [polypeptide binding]; other site 568708012736 putative radical transfer pathway; other site 568708012737 diiron center [ion binding]; other site 568708012738 tyrosyl radical; other site 568708012740 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 568708012741 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 568708012742 Walker A/P-loop; other site 568708012743 ATP binding site [chemical binding]; other site 568708012744 Q-loop/lid; other site 568708012745 ABC transporter signature motif; other site 568708012746 Walker B; other site 568708012747 D-loop; other site 568708012748 H-loop/switch region; other site 568708012749 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 568708012752 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 568708012753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708012754 dimer interface [polypeptide binding]; other site 568708012755 conserved gate region; other site 568708012756 putative PBP binding loops; other site 568708012757 ABC-ATPase subunit interface; other site 568708012758 6 probable transmembrane helices predicted for STM_MW27771 by TMHMM2.0 at aa 94-116, 120-142, 149-171, 197-219, 272-294 and 298-320 568708012760 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 568708012761 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568708012762 Signal peptide predicted for STM_MW27781 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 568708012764 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 568708012765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708012766 Signal peptide predicted for STM_MW27791 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.590 between residues 25 and 26 568708012767 12 probable transmembrane helices predicted for STM_MW27791 by TMHMM2.0 at aa 11-33, 48-70, 77-94, 104-126, 133-155, 160-182, 217-239, 249-271, 278-295, 300-322, 335-357 and 362-384 568708012769 transcriptional repressor MprA; Provisional; Region: PRK10870 568708012770 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568708012772 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 568708012773 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568708012774 HlyD family secretion protein; Region: HlyD_3; pfam13437 568708012775 Signal peptide predicted for STM_MW27811 by SignalP 2.0 HMM (Signal peptide probability 0.966) with cleavage site probability 0.948 between residues 37 and 38 568708012776 1 probable transmembrane helix predicted for STM_MW27811 by TMHMM2.0 at aa 23-45 568708012778 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568708012779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708012780 putative substrate translocation pore; other site 568708012781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708012782 13 probable transmembrane helices predicted for STM_MW27821 by TMHMM2.0 at aa 13-35, 50-72, 79-101, 106-128, 140-162, 167-189, 201-218, 228-250, 270-292, 302-324, 336-353, 368-390 and 480-498 568708012784 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 568708012785 Signal peptide predicted for STM_MW27831 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 568708012786 S-ribosylhomocysteinase; Provisional; Region: PRK02260 568708012788 glutamate--cysteine ligase; Provisional; Region: PRK02107 568708012790 Predicted membrane protein [Function unknown]; Region: COG1238 568708012791 4 probable transmembrane helices predicted for STM_MW27861 by TMHMM2.0 at aa 15-37, 42-64, 84-106 and 118-140 568708012793 Signal peptide predicted for STM_MW27861 by SignalP 2.0 HMM (Signal peptide probability 0.965) with cleavage site probability 0.824 between residues 18 and 19 568708012794 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 568708012795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708012796 motif II; other site 568708012798 carbon storage regulator; Provisional; Region: PRK01712 568708012800 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 568708012801 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 568708012802 motif 1; other site 568708012803 active site 568708012804 motif 2; other site 568708012805 motif 3; other site 568708012806 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 568708012807 DHHA1 domain; Region: DHHA1; pfam02272 568708012811 recombination regulator RecX; Reviewed; Region: recX; PRK00117 568708012813 recombinase A; Provisional; Region: recA; PRK09354 568708012814 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 568708012815 hexamer interface [polypeptide binding]; other site 568708012816 Walker A motif; other site 568708012817 ATP binding site [chemical binding]; other site 568708012818 Walker B motif; other site 568708012820 hypothetical protein; Validated; Region: PRK03661 568708012822 Transglycosylase SLT domain; Region: SLT_2; pfam13406 568708012823 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568708012824 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568708012825 Signal peptide predicted for STM_MW27931 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.784 between residues 25 and 26 568708012826 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 568708012828 3 probable transmembrane helices predicted for STM_MW27941 by TMHMM2.0 at aa 26-48, 68-90 and 134-156 568708012829 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 568708012830 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 568708012831 Nucleoside recognition; Region: Gate; pfam07670 568708012832 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 568708012834 4 probable transmembrane helices predicted for STM_MW27951 by TMHMM2.0 at aa 181-203, 218-240, 247-269 and 300-322 568708012836 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 568708012838 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 568708012839 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 568708012840 putative NAD(P) binding site [chemical binding]; other site 568708012841 active site 568708012843 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 568708012844 Signal peptide predicted for STM_MW27981 by SignalP 2.0 HMM (Signal peptide probability 0.907) with cleavage site probability 0.897 between residues 20 and 21 568708012845 1 probable transmembrane helix predicted for STM_MW27981 by TMHMM2.0 at aa 2-24 568708012847 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 568708012848 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 568708012849 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708012852 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 568708012853 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 568708012854 putative active site [active] 568708012855 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 568708012858 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 568708012859 GAF domain; Region: GAF; pfam01590 568708012860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708012861 Walker A motif; other site 568708012862 ATP binding site [chemical binding]; other site 568708012863 Walker B motif; other site 568708012864 arginine finger; other site 568708012867 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 568708012868 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568708012869 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 568708012870 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 568708012871 iron binding site [ion binding]; other site 568708012875 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 568708012876 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568708012877 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568708012880 Acylphosphatase; Region: Acylphosphatase; pfam00708 568708012881 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 568708012882 HypF finger; Region: zf-HYPF; pfam07503 568708012883 HypF finger; Region: zf-HYPF; pfam07503 568708012884 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 568708012888 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 568708012889 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 568708012891 1 probable transmembrane helix predicted for STM_MW28061 by TMHMM2.0 at aa 13-35 568708012892 Signal peptide predicted for STM_MW28061 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.849 between residues 30 and 31 568708012893 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 568708012894 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 568708012895 nickel binding site [ion binding]; other site 568708012897 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 568708012899 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 568708012901 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 568708012902 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 568708012904 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 568708012905 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 568708012906 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 568708012910 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 568708012911 NADH dehydrogenase; Region: NADHdh; cl00469 568708012912 7 probable transmembrane helices predicted for STM_MW28121 by TMHMM2.0 at aa 5-27, 62-84, 94-111, 132-154, 169-188, 252-274 and 289-306 568708012914 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 568708012915 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568708012916 15 probable transmembrane helices predicted for STM_MW28131 by TMHMM2.0 at aa 4-26, 31-53, 73-95, 108-125, 129-148, 155-177, 197-219, 231-253, 257-279, 292-311, 326-348, 373-395, 415-437, 457-479 and 499-521 568708012918 Signal peptide predicted for STM_MW28131 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.571 between residues 31 and 32 568708012919 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 568708012921 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 568708012923 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 568708012924 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 568708012926 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 568708012928 hydrogenase assembly chaperone; Provisional; Region: PRK10409 568708012930 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 568708012931 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 568708012933 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 568708012934 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 568708012935 dimerization interface [polypeptide binding]; other site 568708012936 ATP binding site [chemical binding]; other site 568708012939 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 568708012940 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 568708012941 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 568708012942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708012943 Walker A motif; other site 568708012944 ATP binding site [chemical binding]; other site 568708012945 Walker B motif; other site 568708012946 arginine finger; other site 568708012947 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568708012951 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 568708012953 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 568708012954 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 568708012955 metal binding site [ion binding]; metal-binding site 568708012956 Signal peptide predicted for STM_MW28231 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 26 and 27 568708012957 1 probable transmembrane helix predicted for STM_MW28231 by TMHMM2.0 at aa 7-26 568708012959 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 568708012960 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 568708012962 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 568708012963 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568708012964 ABC-ATPase subunit interface; other site 568708012965 dimer interface [polypeptide binding]; other site 568708012966 putative PBP binding regions; other site 568708012968 7 probable transmembrane helices predicted for STM_MW28251 by TMHMM2.0 at aa 15-37, 50-72, 92-114, 121-143, 182-204, 217-239 and 249-271 568708012969 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 568708012970 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568708012971 ABC-ATPase subunit interface; other site 568708012972 dimer interface [polypeptide binding]; other site 568708012973 putative PBP binding regions; other site 568708012975 8 probable transmembrane helices predicted for STM_MW28261 by TMHMM2.0 at aa 21-43, 58-80, 93-115, 130-152, 169-191, 196-215, 222-244 and 248-267 568708012976 effector protein YopJ; Provisional; Region: PRK15371 568708012978 transcriptional activator SprB; Provisional; Region: PRK15320 568708012979 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 568708012980 transcriptional regulator SirC; Provisional; Region: PRK15044 568708012981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708012983 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 568708012984 invasion protein OrgB; Provisional; Region: PRK15322 568708012985 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 568708012986 invasion protein OrgA; Provisional; Region: PRK15323 568708012988 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 568708012990 1 probable transmembrane helix predicted for STM_MW28331 by TMHMM2.0 at aa 207-229 568708012991 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 568708012993 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 568708012995 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 568708012996 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 568708012998 1 probable transmembrane helix predicted for STM_MW28361 by TMHMM2.0 at aa 141-163 568708012999 transcriptional regulator HilD; Provisional; Region: PRK15185 568708013000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708013002 invasion protein regulator; Provisional; Region: PRK12370 568708013003 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708013004 DNA binding site [nucleotide binding] 568708013005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568708013006 binding surface 568708013007 TPR motif; other site 568708013009 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 568708013010 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568708013011 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568708013012 catalytic residue [active] 568708013014 pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375 568708013015 SicP binding; Region: SicP-binding; pfam09119 568708013016 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 568708013017 switch II binding region; other site 568708013018 Rac1 P-loop interaction site [polypeptide binding]; other site 568708013019 GTP binding residues [chemical binding]; other site 568708013020 switch I binding region; other site 568708013021 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 568708013022 active site 568708013026 chaperone protein SicP; Provisional; Region: PRK15329 568708013028 putative acyl carrier protein IacP; Validated; Region: PRK08172 568708013030 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 568708013032 cell invasion protein SipD; Provisional; Region: PRK15330 568708013034 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 568708013036 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 568708013037 2 probable transmembrane helices predicted for STM_MW28471 by TMHMM2.0 at aa 320-342 and 408-430 568708013039 chaperone protein SicA; Provisional; Region: PRK15331 568708013040 Tetratricopeptide repeat; Region: TPR_3; pfam07720 568708013041 Tetratricopeptide repeat; Region: TPR_3; pfam07720 568708013043 type III secretion system protein SpaS; Validated; Region: PRK08156 568708013045 4 probable transmembrane helices predicted for STM_MW28491 by TMHMM2.0 at aa 29-51, 72-94, 136-153 and 178-200 568708013046 type III secretion system protein SpaR; Provisional; Region: PRK15332 568708013048 6 probable transmembrane helices predicted for STM_MW28501 by TMHMM2.0 at aa 10-32, 37-59, 79-101, 128-150, 181-203 and 210-232 568708013049 type III secretion system protein SpaQ; Provisional; Region: PRK15333 568708013051 2 probable transmembrane helices predicted for STM_MW28511 by TMHMM2.0 at aa 12-34 and 49-71 568708013052 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 568708013054 3 probable transmembrane helices predicted for STM_MW28521 by TMHMM2.0 at aa 15-37, 50-69 and 161-183 568708013055 type III secretion system protein SpaO; Validated; Region: PRK08158 568708013056 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 568708013058 antigen presentation protein SpaN; Provisional; Region: PRK15334 568708013059 Surface presentation of antigens protein; Region: SPAN; pfam02510 568708013061 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 568708013063 ATP synthase SpaL; Validated; Region: PRK08149 568708013064 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568708013065 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 568708013066 Walker A motif; other site 568708013067 ATP binding site [chemical binding]; other site 568708013068 Walker B motif; other site 568708013070 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 568708013072 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 568708013073 type III secretion system protein InvA; Provisional; Region: PRK15337 568708013075 8 probable transmembrane helices predicted for STM_MW28581 by TMHMM2.0 at aa 13-30, 35-57, 69-91, 106-128, 197-219, 239-261, 274-291 and 296-315 568708013076 type III secretion system regulator InvE; Provisional; Region: PRK15338 568708013077 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 568708013079 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 568708013080 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 568708013081 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 568708013082 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 568708013085 Signal peptide predicted for STM_MW28601 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.635 between residues 24 and 25 568708013086 transcriptional regulator InvF; Provisional; Region: PRK15340 568708013087 InvH outer membrane lipoprotein; Region: InvH; pfam04741 568708013088 Signal peptide predicted for STM_MW28621 by SignalP 2.0 HMM (Signal peptide probability 0.697) with cleavage site probability 0.323 between residues 26 and 27 568708013090 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 568708013092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 568708013096 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 568708013097 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568708013098 active site 568708013099 metal binding site [ion binding]; metal-binding site 568708013101 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 568708013102 MutS domain I; Region: MutS_I; pfam01624 568708013103 MutS domain II; Region: MutS_II; pfam05188 568708013104 MutS domain III; Region: MutS_III; pfam05192 568708013105 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 568708013106 Walker A/P-loop; other site 568708013107 ATP binding site [chemical binding]; other site 568708013108 Q-loop/lid; other site 568708013109 ABC transporter signature motif; other site 568708013110 Walker B; other site 568708013111 D-loop; other site 568708013112 H-loop/switch region; other site 568708013118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 568708013119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708013120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568708013121 putative substrate translocation pore; other site 568708013123 12 probable transmembrane helices predicted for STM_MW28741 by TMHMM2.0 at aa 7-29, 42-64, 69-88, 98-120, 129-151, 161-183, 203-225, 235-257, 270-289, 299-321, 342-361 and 366-388 568708013124 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708013125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708013126 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568708013127 putative effector binding pocket; other site 568708013128 dimerization interface [polypeptide binding]; other site 568708013129 Signal peptide predicted for STM_MW28751 by SignalP 2.0 HMM (Signal peptide probability 0.838) with cleavage site probability 0.374 between residues 30 and 31 568708013132 GntP family permease; Region: GntP_permease; pfam02447 568708013133 fructuronate transporter; Provisional; Region: PRK10034; cl15264 568708013135 12 probable transmembrane helices predicted for STM_MW28761 by TMHMM2.0 at aa 4-23, 30-48, 58-80, 104-126, 176-198, 241-263, 278-300, 320-337, 357-379, 392-414, 434-456 and 463-485 568708013136 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568708013137 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 568708013138 putative NAD(P) binding site [chemical binding]; other site 568708013139 active site 568708013140 putative substrate binding site [chemical binding]; other site 568708013142 hypothetical protein; Provisional; Region: PRK09989 568708013144 putative aldolase; Validated; Region: PRK08130 568708013145 intersubunit interface [polypeptide binding]; other site 568708013146 active site 568708013147 Zn2+ binding site [ion binding]; other site 568708013149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 568708013151 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568708013152 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568708013154 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568708013155 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568708013156 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708013159 MarR family; Region: MarR_2; cl17246 568708013160 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568708013162 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 568708013163 Flavoprotein; Region: Flavoprotein; pfam02441 568708013165 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 568708013167 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 568708013168 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 568708013169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568708013170 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 568708013171 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568708013172 DNA binding residues [nucleotide binding] 568708013177 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 568708013178 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568708013179 Peptidase family M23; Region: Peptidase_M23; pfam01551 568708013182 Signal peptide predicted for STM_MW28881 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.522 between residues 30 and 31 568708013183 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 568708013184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708013185 S-adenosylmethionine binding site [chemical binding]; other site 568708013187 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 568708013189 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 568708013190 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 568708013191 Permutation of conserved domain; other site 568708013192 active site 568708013193 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 568708013195 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 568708013196 homotrimer interaction site [polypeptide binding]; other site 568708013197 zinc binding site [ion binding]; other site 568708013198 CDP-binding sites; other site 568708013200 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 568708013201 substrate binding site; other site 568708013202 dimer interface; other site 568708013204 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 568708013205 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 568708013207 tmhmm; query 1-118 568708013208 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 568708013209 ligand-binding site [chemical binding]; other site 568708013211 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 568708013212 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 568708013213 CysD dimerization site [polypeptide binding]; other site 568708013214 G1 box; other site 568708013215 putative GEF interaction site [polypeptide binding]; other site 568708013216 GTP/Mg2+ binding site [chemical binding]; other site 568708013217 Switch I region; other site 568708013218 G2 box; other site 568708013219 G3 box; other site 568708013220 Switch II region; other site 568708013221 G4 box; other site 568708013222 G5 box; other site 568708013223 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 568708013224 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 568708013227 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 568708013228 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 568708013229 Active Sites [active] 568708013231 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 568708013232 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 568708013233 metal binding site [ion binding]; metal-binding site 568708013234 Signal peptide predicted for STM_MW28991 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 24 and 25 568708013236 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 568708013238 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 568708013240 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 568708013242 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 568708013243 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 568708013244 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 568708013246 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 568708013248 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 568708013250 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 568708013251 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 568708013252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 568708013253 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 568708013255 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 568708013256 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 568708013257 Active Sites [active] 568708013259 sulfite reductase subunit beta; Provisional; Region: PRK13504 568708013260 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 568708013261 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 568708013264 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 568708013265 Flavodoxin; Region: Flavodoxin_1; pfam00258 568708013266 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 568708013267 FAD binding pocket [chemical binding]; other site 568708013268 FAD binding motif [chemical binding]; other site 568708013269 catalytic residues [active] 568708013270 NAD binding pocket [chemical binding]; other site 568708013271 phosphate binding motif [ion binding]; other site 568708013272 beta-alpha-beta structure motif; other site 568708013276 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 568708013277 active site 568708013279 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 568708013281 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 568708013282 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 568708013284 enolase; Provisional; Region: eno; PRK00077 568708013285 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 568708013286 dimer interface [polypeptide binding]; other site 568708013287 metal binding site [ion binding]; metal-binding site 568708013288 substrate binding pocket [chemical binding]; other site 568708013291 CTP synthetase; Validated; Region: pyrG; PRK05380 568708013292 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 568708013293 Catalytic site [active] 568708013294 active site 568708013295 UTP binding site [chemical binding]; other site 568708013296 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 568708013297 active site 568708013298 putative oxyanion hole; other site 568708013299 catalytic triad [active] 568708013302 1 probable transmembrane helix predicted for STM_MW29161 by TMHMM2.0 at aa 7-29 568708013303 Signal peptide predicted for STM_MW29161 by SignalP 2.0 HMM (Signal peptide probability 0.616) with cleavage site probability 0.525 between residues 26 and 27 568708013304 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 568708013305 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 568708013306 homodimer interface [polypeptide binding]; other site 568708013307 metal binding site [ion binding]; metal-binding site 568708013308 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 568708013309 homodimer interface [polypeptide binding]; other site 568708013310 active site 568708013311 putative chemical substrate binding site [chemical binding]; other site 568708013312 metal binding site [ion binding]; metal-binding site 568708013314 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 568708013316 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 568708013318 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 568708013319 HD domain; Region: HD_4; pfam13328 568708013320 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 568708013321 synthetase active site [active] 568708013322 NTP binding site [chemical binding]; other site 568708013323 metal binding site [ion binding]; metal-binding site 568708013324 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 568708013325 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 568708013329 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 568708013330 TRAM domain; Region: TRAM; pfam01938 568708013331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708013332 S-adenosylmethionine binding site [chemical binding]; other site 568708013335 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 568708013336 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 568708013337 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708013338 dimerization interface [polypeptide binding]; other site 568708013339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708013340 dimer interface [polypeptide binding]; other site 568708013341 phosphorylation site [posttranslational modification] 568708013342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708013343 ATP binding site [chemical binding]; other site 568708013344 Mg2+ binding site [ion binding]; other site 568708013345 G-X-G motif; other site 568708013346 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 568708013347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708013348 active site 568708013349 phosphorylation site [posttranslational modification] 568708013350 intermolecular recognition site; other site 568708013351 dimerization interface [polypeptide binding]; other site 568708013352 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 568708013353 putative binding surface; other site 568708013354 active site 568708013355 2 probable transmembrane helices predicted for STM_MW29211 by TMHMM2.0 at aa 10-32 and 177-199 568708013362 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 568708013364 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 568708013365 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 568708013366 active site 568708013367 tetramer interface [polypeptide binding]; other site 568708013369 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 568708013370 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 568708013371 active site 568708013372 tetramer interface [polypeptide binding]; other site 568708013375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708013376 D-galactonate transporter; Region: 2A0114; TIGR00893 568708013377 putative substrate translocation pore; other site 568708013378 12 probable transmembrane helices predicted for STM_MW29251 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 110-132, 152-174, 179-201, 256-278, 293-315, 328-348, 352-374, 387-409 and 414-436 568708013380 flavodoxin; Provisional; Region: PRK08105 568708013382 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568708013383 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 568708013384 probable active site [active] 568708013386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 568708013388 SecY interacting protein Syd; Provisional; Region: PRK04968 568708013390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 568708013391 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 568708013392 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 568708013394 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 568708013395 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 568708013397 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 568708013398 serine transporter; Region: stp; TIGR00814 568708013399 11 probable transmembrane helices predicted for STM_MW29331 by TMHMM2.0 at aa 24-41, 45-67, 103-125, 140-157, 164-186, 206-228, 249-271, 300-322, 351-373, 377-394 and 406-428 568708013401 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 568708013402 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 568708013403 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 568708013406 flap endonuclease-like protein; Provisional; Region: PRK09482 568708013407 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 568708013408 active site 568708013409 metal binding site 1 [ion binding]; metal-binding site 568708013410 putative 5' ssDNA interaction site; other site 568708013411 metal binding site 3; metal-binding site 568708013412 metal binding site 2 [ion binding]; metal-binding site 568708013413 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 568708013414 putative DNA binding site [nucleotide binding]; other site 568708013415 putative metal binding site [ion binding]; other site 568708013418 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 568708013419 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 568708013420 dimer interface [polypeptide binding]; other site 568708013421 active site 568708013422 metal binding site [ion binding]; metal-binding site 568708013424 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 568708013425 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 568708013426 intersubunit interface [polypeptide binding]; other site 568708013427 active site 568708013428 Zn2+ binding site [ion binding]; other site 568708013430 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 568708013431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708013432 putative substrate translocation pore; other site 568708013433 12 probable transmembrane helices predicted for STM_MW29381 by TMHMM2.0 at aa 24-41, 61-83, 88-110, 120-142, 155-177, 212-234, 260-282, 292-314, 327-346, 351-373, 382-404 and 414-431 568708013435 L-fucose isomerase; Provisional; Region: fucI; PRK10991 568708013436 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 568708013437 hexamer (dimer of trimers) interface [polypeptide binding]; other site 568708013438 trimer interface [polypeptide binding]; other site 568708013439 substrate binding site [chemical binding]; other site 568708013440 Mn binding site [ion binding]; other site 568708013444 L-fuculokinase; Provisional; Region: PRK10331 568708013445 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 568708013446 nucleotide binding site [chemical binding]; other site 568708013449 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 568708013451 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 568708013452 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 568708013453 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708013456 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 568708013457 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 568708013459 hypothetical protein; Provisional; Region: PRK10873 568708013460 4 probable transmembrane helices predicted for STM_MW29441 by TMHMM2.0 at aa 5-27, 37-59, 66-88 and 98-120 568708013462 Signal peptide predicted for STM_MW29441 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.682 between residues 24 and 25 568708013463 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568708013464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708013465 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 568708013466 dimerization interface [polypeptide binding]; other site 568708013467 substrate binding pocket [chemical binding]; other site 568708013470 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 568708013472 1 probable transmembrane helix predicted for STM_MW29461 by TMHMM2.0 at aa 5-27 568708013473 Signal peptide predicted for STM_MW29461 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.586 between residues 21 and 22 568708013474 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 568708013475 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 568708013476 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568708013477 catalytic residue [active] 568708013479 CsdA-binding activator; Provisional; Region: PRK15019 568708013481 Predicted permeases [General function prediction only]; Region: RarD; COG2962 568708013482 10 probable transmembrane helices predicted for STM_MW29491 by TMHMM2.0 at aa 2-19, 29-48, 61-83, 88-110, 115-137, 141-158, 165-187, 197-219, 226-248 and 253-275 568708013484 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 568708013485 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 568708013486 putative ATP binding site [chemical binding]; other site 568708013487 putative substrate interface [chemical binding]; other site 568708013489 murein transglycosylase A; Provisional; Region: mltA; PRK11162 568708013490 murein hydrolase B; Provisional; Region: PRK10760; cl17906 568708013491 MltA specific insert domain; Region: MltA; pfam03562 568708013492 3D domain; Region: 3D; pfam06725 568708013495 Signal peptide predicted for STM_MW29511 by SignalP 2.0 HMM (Signal peptide probability 0.911) with cleavage site probability 0.584 between residues 23 and 24 568708013496 AMIN domain; Region: AMIN; pfam11741 568708013497 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 568708013498 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 568708013499 active site 568708013500 metal binding site [ion binding]; metal-binding site 568708013503 Signal peptide predicted for STM_MW29521 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.946 between residues 31 and 32 568708013504 N-acetylglutamate synthase; Validated; Region: PRK05279 568708013505 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 568708013506 putative feedback inhibition sensing region; other site 568708013507 putative nucleotide binding site [chemical binding]; other site 568708013508 putative substrate binding site [chemical binding]; other site 568708013509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708013510 Coenzyme A binding pocket [chemical binding]; other site 568708013513 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 568708013514 AAA domain; Region: AAA_30; pfam13604 568708013515 Family description; Region: UvrD_C_2; pfam13538 568708013518 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 568708013520 protease3; Provisional; Region: PRK15101 568708013521 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 568708013522 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568708013523 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568708013526 Signal peptide predicted for STM_MW29561 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 23 and 24 568708013527 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 568708013528 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 568708013530 hypothetical protein; Provisional; Region: PRK10332 568708013531 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 568708013532 1 probable transmembrane helix predicted for STM_MW29581 by TMHMM2.0 at aa 15-37 568708013533 hypothetical protein; Provisional; Region: PRK11521 568708013535 1 probable transmembrane helix predicted for STM_MW29591 by TMHMM2.0 at aa 10-27 568708013536 Signal peptide predicted for STM_MW29591 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.819 between residues 26 and 27 568708013537 hypothetical protein; Provisional; Region: PRK10557 568708013538 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 568708013539 1 probable transmembrane helix predicted for STM_MW29601 by TMHMM2.0 at aa 7-26 568708013540 hypothetical protein; Provisional; Region: PRK10506 568708013541 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 568708013542 1 probable transmembrane helix predicted for STM_MW29611 by TMHMM2.0 at aa 7-29 568708013543 thymidylate synthase; Reviewed; Region: thyA; PRK01827 568708013544 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 568708013545 dimerization interface [polypeptide binding]; other site 568708013546 active site 568708013548 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 568708013549 5 probable transmembrane helices predicted for STM_MW29631 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 223-245 and 260-282 568708013551 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 568708013552 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 568708013553 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 568708013554 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568708013555 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568708013560 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 568708013561 putative active site [active] 568708013562 Ap4A binding site [chemical binding]; other site 568708013563 nudix motif; other site 568708013564 putative metal binding site [ion binding]; other site 568708013566 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 568708013567 putative DNA-binding cleft [nucleotide binding]; other site 568708013568 putative DNA clevage site; other site 568708013569 molecular lever; other site 568708013571 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 568708013572 7 probable transmembrane helices predicted for STM_MW29671 by TMHMM2.0 at aa 20-42, 55-77, 90-107, 128-145, 160-182, 189-208 and 218-236 568708013574 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 568708013575 Signal peptide predicted for STM_MW29681 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.678 between residues 19 and 20 568708013576 1 probable transmembrane helix predicted for STM_MW29681 by TMHMM2.0 at aa 4-26 568708013578 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568708013579 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568708013580 active site 568708013581 catalytic tetrad [active] 568708013583 lysophospholipid transporter LplT; Provisional; Region: PRK11195 568708013584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708013585 12 probable transmembrane helices predicted for STM_MW29701 by TMHMM2.0 at aa 19-41, 51-73, 94-116, 136-158, 163-185, 195-213, 220-242, 257-279, 286-305, 309-331, 344-366 and 371-393 568708013587 Signal peptide predicted for STM_MW29701 by SignalP 2.0 HMM (Signal peptide probability 0.668) with cleavage site probability 0.639 between residues 29 and 30 568708013588 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 568708013589 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568708013590 putative acyl-acceptor binding pocket; other site 568708013591 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 568708013592 acyl-activating enzyme (AAE) consensus motif; other site 568708013593 putative AMP binding site [chemical binding]; other site 568708013596 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 568708013597 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708013598 DNA binding site [nucleotide binding] 568708013599 domain linker motif; other site 568708013600 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 568708013601 dimerization interface (closed form) [polypeptide binding]; other site 568708013602 ligand binding site [chemical binding]; other site 568708013605 pfam_scan;Pfam:PF00356; E()=1.3E-18;score=66.2;query4-49;description=LacI; pfam_scan;Pfam:PF00532; E()=8.3E-31;score=106.7;query 61-286;description=Peripla_BP_1 568708013608 diaminopimelate decarboxylase; Provisional; Region: PRK11165 568708013609 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 568708013610 active site 568708013611 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568708013612 substrate binding site [chemical binding]; other site 568708013613 catalytic residues [active] 568708013614 dimer interface [polypeptide binding]; other site 568708013617 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 568708013618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708013619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568708013620 dimerization interface [polypeptide binding]; other site 568708013623 putative racemase; Provisional; Region: PRK10200 568708013624 aspartate racemase; Region: asp_race; TIGR00035 568708013626 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 568708013627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708013628 putative substrate translocation pore; other site 568708013629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708013631 12 probable transmembrane helices predicted for STM_MW29781 by TMHMM2.0 at aa 24-46, 61-83, 90-112, 116-138, 150-167, 177-199, 259-281, 296-318, 325-347, 362-384, 397-419 and 424-446 568708013632 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 568708013633 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 568708013634 NADP binding site [chemical binding]; other site 568708013635 homodimer interface [polypeptide binding]; other site 568708013636 active site 568708013638 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 568708013640 putative acyltransferase; Provisional; Region: PRK05790 568708013641 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568708013642 dimer interface [polypeptide binding]; other site 568708013643 active site 568708013646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708013647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708013648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568708013649 dimerization interface [polypeptide binding]; other site 568708013652 Predicted membrane protein [Function unknown]; Region: COG4125 568708013653 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 568708013654 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 568708013656 4 probable transmembrane helices predicted for STM_MW29831 by TMHMM2.0 at aa 24-46, 56-75, 95-117 and 121-143 568708013657 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 568708013658 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 568708013660 10 probable transmembrane helices predicted for STM_MW29841 by TMHMM2.0 at aa 20-42, 86-108, 123-145, 152-174, 194-216, 236-258, 287-309, 334-356, 360-382 and 389-408 568708013661 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 568708013662 putative metal binding site [ion binding]; other site 568708013663 putative homodimer interface [polypeptide binding]; other site 568708013664 putative homotetramer interface [polypeptide binding]; other site 568708013665 putative homodimer-homodimer interface [polypeptide binding]; other site 568708013666 putative allosteric switch controlling residues; other site 568708013668 transcriptional activator SprB; Provisional; Region: PRK15320 568708013669 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 568708013670 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 568708013672 Fimbrial protein; Region: Fimbrial; pfam00419 568708013673 Signal peptide predicted for STM_MW29881 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 29 and 30 568708013674 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 568708013675 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708013676 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708013679 Signal peptide predicted for STM_MW29891 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.677 between residues 27 and 28 568708013680 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 568708013681 PapC N-terminal domain; Region: PapC_N; pfam13954 568708013682 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568708013683 PapC C-terminal domain; Region: PapC_C; pfam13953 568708013685 Signal peptide predicted for STM_MW29901 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.994 between residues 21 and 22 568708013686 fimbrial protein StdA; Provisional; Region: PRK15210 568708013688 2 probable transmembrane helices predicted for STM_MW29911 by TMHMM2.0 at aa 15-34 and 47-69 568708013689 Signal peptide predicted for STM_MW29911 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.981 between residues 64 and 65 568708013690 hypothetical protein; Provisional; Region: PRK10316 568708013691 YfdX protein; Region: YfdX; pfam10938 568708013693 Signal peptide predicted for STM_MW29921 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23 568708013694 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 568708013696 Signal peptide predicted for STM_MW29931 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25 568708013697 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 568708013698 oligomeric interface; other site 568708013699 putative active site [active] 568708013700 homodimer interface [polypeptide binding]; other site 568708013702 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 568708013703 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 568708013704 Signal peptide predicted for STM_MW29961 by SignalP 2.0 HMM (Signal peptide probability 0.676) with cleavage site probability 0.628 between residues 28 and 29 568708013705 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 568708013707 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568708013708 Peptidase family M23; Region: Peptidase_M23; pfam01551 568708013711 Signal peptide predicted for STM_MW29981 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.446 between residues 32 and 33 568708013712 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 568708013713 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 568708013714 active site 568708013715 metal binding site [ion binding]; metal-binding site 568708013716 nudix motif; other site 568708013718 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 568708013719 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 568708013720 dimer interface [polypeptide binding]; other site 568708013721 putative anticodon binding site; other site 568708013722 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 568708013723 motif 1; other site 568708013724 active site 568708013725 motif 2; other site 568708013726 motif 3; other site 568708013729 This domain is found in peptide chain release factors; Region: PCRF; smart00937 568708013730 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 568708013731 RF-1 domain; Region: RF-1; pfam00472 568708013734 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 568708013735 DHH family; Region: DHH; pfam01368 568708013736 DHHA1 domain; Region: DHHA1; pfam02272 568708013739 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 568708013740 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 568708013741 dimerization domain [polypeptide binding]; other site 568708013742 dimer interface [polypeptide binding]; other site 568708013743 catalytic residues [active] 568708013745 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 568708013746 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 568708013747 active site 568708013748 Int/Topo IB signature motif; other site 568708013751 flavodoxin FldB; Provisional; Region: PRK12359 568708013753 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 568708013755 1 probable transmembrane helix predicted for STM_MW30061 by TMHMM2.0 at aa 20-51 568708013756 hypothetical protein; Provisional; Region: PRK10878 568708013758 putative global regulator; Reviewed; Region: PRK09559 568708013759 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 568708013761 hemolysin; Provisional; Region: PRK15087 568708013762 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 568708013763 7 probable transmembrane helices predicted for STM_MW30091 by TMHMM2.0 at aa 20-42, 46-68, 89-107, 112-134, 139-161, 165-187 and 194-216 568708013765 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 568708013767 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 568708013768 beta-galactosidase; Region: BGL; TIGR03356 568708013770 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 568708013771 glycine dehydrogenase; Provisional; Region: PRK05367 568708013772 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 568708013773 tetramer interface [polypeptide binding]; other site 568708013774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708013775 catalytic residue [active] 568708013776 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 568708013777 tetramer interface [polypeptide binding]; other site 568708013778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708013779 catalytic residue [active] 568708013781 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 568708013782 lipoyl attachment site [posttranslational modification]; other site 568708013784 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 568708013785 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 568708013788 oxidoreductase; Provisional; Region: PRK08013 568708013789 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 568708013791 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 568708013792 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 568708013794 Signal peptide predicted for STM_MW30171 by SignalP 2.0 HMM (Signal peptide probability 0.954) with cleavage site probability 0.777 between residues 25 and 26 568708013795 proline aminopeptidase P II; Provisional; Region: PRK10879 568708013796 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 568708013797 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 568708013798 active site 568708013801 hypothetical protein; Reviewed; Region: PRK01736 568708013803 Z-ring-associated protein; Provisional; Region: PRK10972 568708013805 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 568708013806 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 568708013808 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 568708013809 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 568708013810 ligand binding site [chemical binding]; other site 568708013811 NAD binding site [chemical binding]; other site 568708013812 tetramer interface [polypeptide binding]; other site 568708013813 catalytic site [active] 568708013814 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 568708013815 L-serine binding site [chemical binding]; other site 568708013816 ACT domain interface; other site 568708013820 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 568708013821 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568708013822 active site 568708013823 dimer interface [polypeptide binding]; other site 568708013825 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 568708013826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708013827 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 568708013828 putative dimerization interface [polypeptide binding]; other site 568708013831 Uncharacterized conserved protein [Function unknown]; Region: COG2968 568708013832 oxidative stress defense protein; Provisional; Region: PRK11087 568708013834 Signal peptide predicted for STM_MW30261 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 568708013835 arginine exporter protein; Provisional; Region: PRK09304 568708013836 6 probable transmembrane helices predicted for STM_MW30271 by TMHMM2.0 at aa 4-26, 39-61, 66-88, 111-133, 148-170 and 182-199 568708013838 mechanosensitive channel MscS; Provisional; Region: PRK10334 568708013839 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568708013842 3 probable transmembrane helices predicted for STM_MW30281 by TMHMM2.0 at aa 26-48, 68-90 and 105-127 568708013843 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 568708013844 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 568708013845 active site 568708013846 intersubunit interface [polypeptide binding]; other site 568708013847 zinc binding site [ion binding]; other site 568708013848 Na+ binding site [ion binding]; other site 568708013850 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 568708013851 Phosphoglycerate kinase; Region: PGK; pfam00162 568708013852 substrate binding site [chemical binding]; other site 568708013853 hinge regions; other site 568708013854 ADP binding site [chemical binding]; other site 568708013855 catalytic site [active] 568708013857 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 568708013858 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 568708013859 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 568708013862 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 568708013863 trimer interface [polypeptide binding]; other site 568708013864 putative Zn binding site [ion binding]; other site 568708013866 5 probable transmembrane helices predicted for STM_MW30331 by TMHMM2.0 at aa 10-29, 42-64, 74-96, 103-125 and 152-174 568708013867 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 568708013868 Signal peptide predicted for STM_MW30341 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.463 between residues 24 and 25 568708013870 4 probable transmembrane helices predicted for STM_MW30341 by TMHMM2.0 at aa 15-37, 50-72, 82-104 and 215-234 568708013871 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568708013872 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568708013873 Walker A/P-loop; other site 568708013874 ATP binding site [chemical binding]; other site 568708013875 Q-loop/lid; other site 568708013876 ABC transporter signature motif; other site 568708013877 Walker B; other site 568708013878 D-loop; other site 568708013879 H-loop/switch region; other site 568708013881 pfam_scan;Pfam:PF00005; E()=4.9E-31;score=107.9;query 29-197;description=ABC_tran 568708013883 transketolase; Reviewed; Region: PRK12753 568708013884 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 568708013885 TPP-binding site [chemical binding]; other site 568708013886 dimer interface [polypeptide binding]; other site 568708013887 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568708013888 PYR/PP interface [polypeptide binding]; other site 568708013889 dimer interface [polypeptide binding]; other site 568708013890 TPP binding site [chemical binding]; other site 568708013891 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568708013895 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 568708013897 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 568708013898 agmatinase; Region: agmatinase; TIGR01230 568708013899 oligomer interface [polypeptide binding]; other site 568708013900 putative active site [active] 568708013901 Mn binding site [ion binding]; other site 568708013903 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 568708013905 1 probable transmembrane helix predicted for STM_MW30401 by TMHMM2.0 at aa 7-26 568708013906 Signal peptide predicted for STM_MW30401 by SignalP 2.0 HMM (Signal peptide probability 0.815) with cleavage site probability 0.482 between residues 23 and 24 568708013907 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 568708013909 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 568708013911 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 568708013912 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 568708013913 putative NAD(P) binding site [chemical binding]; other site 568708013914 catalytic Zn binding site [ion binding]; other site 568708013915 structural Zn binding site [ion binding]; other site 568708013918 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 568708013919 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 568708013920 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 568708013923 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568708013924 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708013925 DNA-binding site [nucleotide binding]; DNA binding site 568708013926 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568708013929 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 568708013930 Signal peptide predicted for STM_MW30461 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.301 between residues 25 and 26 568708013931 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 568708013932 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 568708013933 dimer interface [polypeptide binding]; other site 568708013934 active site 568708013935 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568708013936 catalytic residues [active] 568708013937 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 568708013940 Virulence promoting factor; Region: YqgB; pfam11036 568708013942 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 568708013944 2 probable transmembrane helices predicted for STM_MW30501 by TMHMM2.0 at aa 21-43 and 63-77 568708013945 S-adenosylmethionine synthetase; Validated; Region: PRK05250 568708013946 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 568708013947 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 568708013948 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 568708013952 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 568708013953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708013954 putative substrate translocation pore; other site 568708013955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708013956 Signal peptide predicted for STM_MW30521 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.892 between residues 30 and 31 568708013957 12 probable transmembrane helices predicted for STM_MW30521 by TMHMM2.0 at aa 13-35, 55-77, 84-103, 108-130, 142-159, 169-191, 252-274, 289-311, 318-340, 350-372, 385-407 and 417-436 568708013959 hypothetical protein; Provisional; Region: PRK04860 568708013960 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 568708013962 DNA-specific endonuclease I; Provisional; Region: PRK15137 568708013963 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 568708013964 Signal peptide predicted for STM_MW30541 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708013966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 568708013967 RNA methyltransferase, RsmE family; Region: TIGR00046 568708013969 glutathione synthetase; Provisional; Region: PRK05246 568708013970 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 568708013971 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 568708013974 hypothetical protein; Validated; Region: PRK00228 568708013976 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 568708013978 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568708013979 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568708013980 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 568708013981 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 568708013982 Walker A motif; other site 568708013983 ATP binding site [chemical binding]; other site 568708013984 Walker B motif; other site 568708013986 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 568708013987 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568708013988 catalytic residue [active] 568708013990 YGGT family; Region: YGGT; pfam02325 568708013991 YGGT family; Region: YGGT; pfam02325 568708013992 4 probable transmembrane helices predicted for STM_MW30621 by TMHMM2.0 at aa 5-24, 63-85, 89-111 and 153-175 568708013994 hypothetical protein; Validated; Region: PRK05090 568708013996 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 568708013997 active site 568708013998 dimerization interface [polypeptide binding]; other site 568708014000 HemN family oxidoreductase; Provisional; Region: PRK05660 568708014001 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708014002 FeS/SAM binding site; other site 568708014003 HemN C-terminal domain; Region: HemN_C; pfam06969 568708014006 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 568708014008 Signal peptide predicted for STM_MW30661 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 21 and 22 568708014009 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 568708014010 homodimer interface [polypeptide binding]; other site 568708014011 active site 568708014013 1 probable transmembrane helix predicted for STM_MW30671 by TMHMM2.0 at aa 7-29 568708014014 Signal peptide predicted for STM_MW30671 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708014015 hypothetical protein; Provisional; Region: PRK10626 568708014016 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 568708014018 Signal peptide predicted for STM_MW30681 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.735 between residues 20 and 21 568708014019 hypothetical protein; Provisional; Region: PRK11702 568708014021 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 568708014023 adenine DNA glycosylase; Provisional; Region: PRK10880 568708014024 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568708014025 minor groove reading motif; other site 568708014026 helix-hairpin-helix signature motif; other site 568708014027 substrate binding pocket [chemical binding]; other site 568708014028 active site 568708014029 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 568708014030 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 568708014031 DNA binding and oxoG recognition site [nucleotide binding] 568708014035 oxidative damage protection protein; Provisional; Region: PRK05408 568708014037 murein transglycosylase C; Provisional; Region: mltC; PRK11671 568708014038 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 568708014039 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568708014040 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568708014041 catalytic residue [active] 568708014042 Signal peptide predicted for STM_MW30731 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.564 between residues 23 and 24 568708014044 nucleoside transporter; Region: 2A0110; TIGR00889 568708014046 12 probable transmembrane helices predicted for STM_MW30741 by TMHMM2.0 at aa 9-31, 41-63, 70-87, 92-114, 135-152, 162-184, 211-233, 253-275, 282-301, 311-333, 346-365 and 380-402 568708014047 ornithine decarboxylase; Provisional; Region: PRK13578 568708014048 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 568708014049 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 568708014050 homodimer interface [polypeptide binding]; other site 568708014051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708014052 catalytic residue [active] 568708014053 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 568708014057 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 568708014059 6 probable transmembrane helices predicted for STM_MW30761 by TMHMM2.0 at aa 4-23, 36-58, 102-124, 145-167, 177-199 and 211-233 568708014060 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 568708014061 dimer interface [polypeptide binding]; other site 568708014062 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568708014063 metal binding site [ion binding]; metal-binding site 568708014065 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 568708014066 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 568708014067 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 568708014069 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 568708014070 putative active site [active] 568708014071 putative catalytic site [active] 568708014073 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 568708014075 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 568708014076 putative dimerization interface [polypeptide binding]; other site 568708014077 putative substrate binding pocket [chemical binding]; other site 568708014079 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 568708014080 Sulfatase; Region: Sulfatase; pfam00884 568708014082 Signal peptide predicted for STM_MW30821 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.993 between residues 20 and 21 568708014083 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 568708014084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708014085 FeS/SAM binding site; other site 568708014086 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 568708014087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568708014088 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708014089 DNA binding residues [nucleotide binding] 568708014090 dimerization interface [polypeptide binding]; other site 568708014092 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 568708014094 Amino acid permease; Region: AA_permease_2; pfam13520 568708014096 12 probable transmembrane helices predicted for STM_MW30861 by TMHMM2.0 at aa 13-35, 48-70, 90-121, 136-158, 165-187, 202-224, 236-258, 293-315, 345-362, 372-394, 407-429 and 439-456 568708014097 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 568708014099 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 568708014100 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568708014102 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 568708014103 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568708014104 NAD(P) binding site [chemical binding]; other site 568708014105 catalytic residues [active] 568708014107 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 568708014109 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 568708014111 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 568708014112 active site 568708014113 catalytic site [active] 568708014114 Zn binding site [ion binding]; other site 568708014115 tetramer interface [polypeptide binding]; other site 568708014117 Predicted amidohydrolase [General function prediction only]; Region: COG0388 568708014118 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 568708014119 putative active site [active] 568708014120 catalytic triad [active] 568708014121 putative dimer interface [polypeptide binding]; other site 568708014123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708014124 D-galactonate transporter; Region: 2A0114; TIGR00893 568708014125 putative substrate translocation pore; other site 568708014127 9 probable transmembrane helices predicted for STM_MW30941 by TMHMM2.0 at aa 7-29, 75-97, 137-159, 169-191, 236-258, 268-290, 311-333, 362-384 and 393-415 568708014128 Signal peptide predicted for STM_MW30941 by SignalP 2.0 HMM (Signal peptide probability 0.887) with cleavage site probability 0.627 between residues 31 and 32 568708014129 mannonate dehydratase; Provisional; Region: PRK03906 568708014130 mannonate dehydratase; Region: uxuA; TIGR00695 568708014132 D-mannonate oxidoreductase; Provisional; Region: PRK15037 568708014133 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 568708014134 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 568708014137 Glucuronate isomerase; Region: UxaC; pfam02614 568708014138 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 568708014140 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568708014141 dimer interface [polypeptide binding]; other site 568708014142 putative CheW interface [polypeptide binding]; other site 568708014143 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 568708014145 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 568708014146 CHAP domain; Region: CHAP; pfam05257 568708014147 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 568708014150 1 probable transmembrane helix predicted for STM_MW30991 by TMHMM2.0 at aa 65-84 568708014151 putative S-transferase; Provisional; Region: PRK11752 568708014152 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 568708014153 C-terminal domain interface [polypeptide binding]; other site 568708014154 GSH binding site (G-site) [chemical binding]; other site 568708014155 dimer interface [polypeptide binding]; other site 568708014156 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 568708014157 dimer interface [polypeptide binding]; other site 568708014158 N-terminal domain interface [polypeptide binding]; other site 568708014159 active site 568708014162 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568708014163 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 568708014164 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 568708014165 putative ligand binding residues [chemical binding]; other site 568708014166 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 568708014168 Signal peptide predicted for STM_MW31021 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.913 between residues 23 and 24 568708014169 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 568708014171 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 568708014172 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 568708014174 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 568708014175 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 568708014176 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 568708014177 putative substrate-binding site; other site 568708014178 nickel binding site [ion binding]; other site 568708014180 hydrogenase 2 large subunit; Provisional; Region: PRK10467 568708014181 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 568708014183 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 568708014184 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 568708014185 10 probable transmembrane helices predicted for STM_MW31081 by TMHMM2.0 at aa 13-32, 52-74, 86-108, 128-150, 171-193, 208-227, 246-268, 283-302, 315-337 and 352-374 568708014187 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 568708014188 4Fe-4S binding domain; Region: Fer4_6; pfam12837 568708014190 Signal peptide predicted for STM_MW31091 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 26 and 27 568708014191 hydrogenase 2 small subunit; Provisional; Region: PRK10468 568708014192 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 568708014193 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 568708014194 1 probable transmembrane helix predicted for STM_MW31101 by TMHMM2.0 at aa 332-354 568708014196 Signal peptide predicted for STM_MW31101 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.857 between residues 37 and 38 568708014197 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 568708014199 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 568708014200 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708014201 dimerization interface [polypeptide binding]; other site 568708014202 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568708014203 dimer interface [polypeptide binding]; other site 568708014204 putative CheW interface [polypeptide binding]; other site 568708014206 2 probable transmembrane helices predicted for STM_MW31121 by TMHMM2.0 at aa 10-32 and 190-212 568708014207 Signal peptide predicted for STM_MW31121 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.645 between residues 36 and 37 568708014208 hypothetical protein; Provisional; Region: PRK05208 568708014210 3 probable transmembrane helices predicted for STM_MW31131 by TMHMM2.0 at aa 10-32, 53-75 and 136-155 568708014211 1 probable transmembrane helix predicted for STM_MW31141 by TMHMM2.0 at aa 7-29 568708014212 oxidoreductase; Provisional; Region: PRK07985 568708014213 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 568708014214 NAD binding site [chemical binding]; other site 568708014215 metal binding site [ion binding]; metal-binding site 568708014216 active site 568708014218 biopolymer transport protein ExbD; Provisional; Region: PRK11267 568708014219 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 568708014221 1 probable transmembrane helix predicted for STM_MW31181 by TMHMM2.0 at aa 20-42 568708014222 biopolymer transport protein ExbB; Provisional; Region: PRK10414 568708014223 3 probable transmembrane helices predicted for STM_MW31191 by TMHMM2.0 at aa 20-42, 131-153 and 177-199 568708014225 cystathionine beta-lyase; Provisional; Region: PRK08114 568708014226 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568708014227 homodimer interface [polypeptide binding]; other site 568708014228 substrate-cofactor binding pocket; other site 568708014229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708014230 catalytic residue [active] 568708014232 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568708014233 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 568708014234 4 probable transmembrane helices predicted for STM_MW31221 by TMHMM2.0 at aa 16-38, 66-88, 158-180 and 190-212 568708014236 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 568708014237 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 568708014238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708014239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708014242 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 568708014243 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 568708014244 dimer interface [polypeptide binding]; other site 568708014245 active site 568708014246 metal binding site [ion binding]; metal-binding site 568708014248 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568708014249 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568708014250 active site 568708014251 catalytic tetrad [active] 568708014253 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 568708014254 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 568708014255 transmembrane helices; other site 568708014257 12 probable transmembrane helices predicted for STM_MW31261 by TMHMM2.0 at aa 13-30, 45-77, 90-112, 127-149, 192-214, 229-251, 281-300, 304-323, 336-358, 373-395, 402-424 and 461-483 568708014258 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 568708014259 nucleotide binding site/active site [active] 568708014260 catalytic residue [active] 568708014262 hypothetical protein; Provisional; Region: PRK01254 568708014263 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 568708014264 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 568708014267 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568708014268 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 568708014269 Signal peptide predicted for STM_MW31291 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 26 and 27 568708014270 1 probable transmembrane helix predicted for STM_MW31291 by TMHMM2.0 at aa 7-26 568708014272 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 568708014273 Signal peptide predicted for STM_MW31301 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.401 between residues 28 and 29 568708014274 4 probable transmembrane helices predicted for STM_MW31301 by TMHMM2.0 at aa 11-33, 48-66, 89-111 and 131-151 568708014276 DctM-like transporters; Region: DctM; pfam06808 568708014277 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 568708014278 11 probable transmembrane helices predicted for STM_MW31311 by TMHMM2.0 at aa 7-29, 62-84, 105-127, 147-169, 176-198, 229-258, 279-301, 321-338, 343-360, 370-392 and 404-426 568708014280 FtsI repressor; Provisional; Region: PRK10883 568708014281 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 568708014282 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 568708014285 Signal peptide predicted for STM_MW31321 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 27 and 28 568708014286 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 568708014287 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568708014288 putative acyl-acceptor binding pocket; other site 568708014290 1 probable transmembrane helix predicted for STM_MW31331 by TMHMM2.0 at aa 2-24 568708014291 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 568708014292 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 568708014293 CAP-like domain; other site 568708014294 active site 568708014295 primary dimer interface [polypeptide binding]; other site 568708014296 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568708014299 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568708014300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708014301 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 568708014304 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 568708014306 Signal peptide predicted for STM_MW31361 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 20 and 21 568708014307 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 568708014308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708014309 active site 568708014310 phosphorylation site [posttranslational modification] 568708014311 intermolecular recognition site; other site 568708014312 dimerization interface [polypeptide binding]; other site 568708014313 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708014314 DNA binding site [nucleotide binding] 568708014317 sensor protein QseC; Provisional; Region: PRK10337 568708014318 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 568708014319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708014320 dimer interface [polypeptide binding]; other site 568708014321 phosphorylation site [posttranslational modification] 568708014322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708014323 ATP binding site [chemical binding]; other site 568708014324 Mg2+ binding site [ion binding]; other site 568708014325 G-X-G motif; other site 568708014326 Signal peptide predicted for STM_MW31381 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.861 between residues 31 and 32 568708014327 2 probable transmembrane helices predicted for STM_MW31381 by TMHMM2.0 at aa 13-32 and 159-181 568708014330 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 568708014332 Uncharacterized conserved protein [Function unknown]; Region: COG1359 568708014334 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 568708014335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708014336 ATP binding site [chemical binding]; other site 568708014337 Mg2+ binding site [ion binding]; other site 568708014338 G-X-G motif; other site 568708014339 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 568708014340 anchoring element; other site 568708014341 dimer interface [polypeptide binding]; other site 568708014342 ATP binding site [chemical binding]; other site 568708014343 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 568708014344 active site 568708014345 metal binding site [ion binding]; metal-binding site 568708014346 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568708014350 esterase YqiA; Provisional; Region: PRK11071 568708014352 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 568708014353 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568708014354 active site 568708014355 metal binding site [ion binding]; metal-binding site 568708014356 hexamer interface [polypeptide binding]; other site 568708014359 putative dehydrogenase; Provisional; Region: PRK11039 568708014361 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 568708014362 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 568708014363 dimer interface [polypeptide binding]; other site 568708014364 ADP-ribose binding site [chemical binding]; other site 568708014365 active site 568708014366 nudix motif; other site 568708014367 metal binding site [ion binding]; metal-binding site 568708014369 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 568708014370 Signal peptide predicted for STM_MW31461 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 24 and 25 568708014372 hypothetical protein; Provisional; Region: PRK11653 568708014373 Signal peptide predicted for STM_MW31471 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.413 between residues 36 and 37 568708014375 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 568708014377 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 568708014378 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 568708014379 putative active site [active] 568708014380 metal binding site [ion binding]; metal-binding site 568708014382 zinc transporter ZupT; Provisional; Region: PRK04201 568708014383 ZIP Zinc transporter; Region: Zip; pfam02535 568708014384 Signal peptide predicted for STM_MW31501 by SignalP 2.0 HMM (Signal peptide probability 0.962) with cleavage site probability 0.814 between residues 25 and 26 568708014385 8 probable transmembrane helices predicted for STM_MW31501 by TMHMM2.0 at aa 5-24, 31-50, 65-87, 108-130, 140-162, 169-191, 195-217 and 234-256 568708014387 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 568708014388 1 probable transmembrane helix predicted for STM_MW31511 by TMHMM2.0 at aa 4-21 568708014389 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 568708014390 Signal peptide predicted for STM_MW31521 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 27 and 28 568708014391 1 probable transmembrane helix predicted for STM_MW31521 by TMHMM2.0 at aa 9-31 568708014393 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 568708014394 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 568708014395 catalytic residues [active] 568708014396 hinge region; other site 568708014397 alpha helical domain; other site 568708014398 Signal peptide predicted for STM_MW31541 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.751 between residues 27 and 28 568708014400 putative disulfide oxidoreductase; Provisional; Region: PRK04307 568708014402 4 probable transmembrane helices predicted for STM_MW31551 by TMHMM2.0 at aa 27-49, 59-78, 83-105 and 197-219 568708014403 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 568708014404 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 568708014406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 568708014408 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 568708014410 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 568708014412 3 probable transmembrane helices predicted for STM_MW31591 by TMHMM2.0 at aa 13-35, 63-85 and 98-117 568708014413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 568708014414 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 568708014415 2 probable transmembrane helices predicted for STM_MW31601 by TMHMM2.0 at aa 11-33 and 46-68 568708014416 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 568708014417 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 568708014418 putative ribose interaction site [chemical binding]; other site 568708014419 putative ADP binding site [chemical binding]; other site 568708014420 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 568708014421 active site 568708014422 nucleotide binding site [chemical binding]; other site 568708014423 HIGH motif; other site 568708014424 KMSKS motif; other site 568708014427 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 568708014428 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 568708014429 metal binding triad; other site 568708014430 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 568708014431 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 568708014432 metal binding triad; other site 568708014433 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 568708014436 Uncharacterized conserved protein [Function unknown]; Region: COG3025 568708014437 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 568708014438 putative active site [active] 568708014439 putative metal binding residues [ion binding]; other site 568708014440 signature motif; other site 568708014441 putative triphosphate binding site [ion binding]; other site 568708014442 CHAD domain; Region: CHAD; pfam05235 568708014444 SH3 domain-containing protein; Provisional; Region: PRK10884 568708014445 Bacterial SH3 domain homologues; Region: SH3b; smart00287 568708014446 Signal peptide predicted for STM_MW31641 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 22 and 23 568708014448 1 probable transmembrane helix predicted for STM_MW31641 by TMHMM2.0 at aa 167-189 568708014449 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 568708014450 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 568708014451 active site 568708014452 NTP binding site [chemical binding]; other site 568708014453 metal binding triad [ion binding]; metal-binding site 568708014454 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 568708014455 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568708014456 Zn2+ binding site [ion binding]; other site 568708014457 Mg2+ binding site [ion binding]; other site 568708014460 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 568708014461 7 probable transmembrane helices predicted for STM_MW31661 by TMHMM2.0 at aa 7-29, 49-71, 91-110, 120-137, 188-210, 225-247 and 254-273 568708014463 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 568708014464 homooctamer interface [polypeptide binding]; other site 568708014465 active site 568708014467 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 568708014468 5 probable transmembrane helices predicted for STM_MW31681 by TMHMM2.0 at aa 4-26, 53-75, 80-102, 109-131 and 136-158 568708014470 UGMP family protein; Validated; Region: PRK09604 568708014471 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 568708014473 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 568708014475 DNA primase; Validated; Region: dnaG; PRK05667 568708014476 CHC2 zinc finger; Region: zf-CHC2; pfam01807 568708014477 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 568708014478 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 568708014479 active site 568708014480 metal binding site [ion binding]; metal-binding site 568708014481 interdomain interaction site; other site 568708014482 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 568708014483 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 568708014489 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 568708014490 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 568708014491 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 568708014492 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 568708014493 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568708014494 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 568708014495 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568708014496 DNA binding residues [nucleotide binding] 568708014503 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 568708014504 active site 568708014505 SUMO-1 interface [polypeptide binding]; other site 568708014507 BTP5 568708014508 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 568708014509 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 568708014511 tail protein; Provisional; Region: D; PHA02561 568708014513 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 568708014515 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 568708014516 4 probable transmembrane helices predicted for STM_MW31771 by TMHMM2.0 at aa 538-560, 567-589, 593-612 and 619-638 568708014518 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 568708014520 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 568708014522 major tail tube protein; Provisional; Region: FII; PHA02600 568708014524 major tail sheath protein; Provisional; Region: FI; PHA02560 568708014526 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 568708014528 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 568708014529 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 568708014530 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 568708014531 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 568708014532 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 568708014534 Signal peptide predicted for STM_MW31841 by SignalP 2.0 HMM (Signal peptide probability 0.894) with cleavage site probability 0.829 between residues 19 and 20 568708014535 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 568708014537 baseplate assembly protein; Provisional; Region: J; PHA02568 568708014539 baseplate wedge subunit; Provisional; Region: W; PHA02516 568708014541 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 568708014542 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 568708014544 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 568708014546 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 568708014548 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 568708014549 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 568708014550 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568708014551 catalytic residue [active] 568708014553 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 568708014555 terminase endonuclease subunit; Provisional; Region: M; PHA02537 568708014556 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 568708014558 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 568708014560 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 568708014562 terminase ATPase subunit; Provisional; Region: P; PHA02535 568708014563 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 568708014566 portal vertex protein; Provisional; Region: Q; PHA02536 568708014567 Phage portal protein; Region: Phage_portal; pfam04860 568708014569 2 probable transmembrane helices predicted for STM_MW32031 by TMHMM2.0 at aa 4-21 and 34-53 568708014570 DinI-like family; Region: DinI; pfam06183 568708014572 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 568708014574 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 568708014576 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 568708014577 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568708014578 active site 568708014579 catalytic site [active] 568708014580 substrate binding site [chemical binding]; other site 568708014582 DksA-like zinc finger domain containing protein; Region: PHA00080 568708014584 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 568708014586 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 568708014588 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 568708014590 integrase; Provisional; Region: int; PHA02601 568708014591 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568708014592 active site 568708014593 DNA binding site [nucleotide binding] 568708014594 Int/Topo IB signature motif; other site 568708014596 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 568708014597 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 568708014598 FAD binding pocket [chemical binding]; other site 568708014599 FAD binding motif [chemical binding]; other site 568708014600 phosphate binding motif [ion binding]; other site 568708014601 NAD binding pocket [chemical binding]; other site 568708014604 Predicted transcriptional regulators [Transcription]; Region: COG1695 568708014605 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 568708014607 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 568708014608 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708014609 dimerization interface [polypeptide binding]; other site 568708014610 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 568708014611 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568708014612 dimer interface [polypeptide binding]; other site 568708014613 putative CheW interface [polypeptide binding]; other site 568708014615 2 probable transmembrane helices predicted for STM_MW32171 by TMHMM2.0 at aa 12-34 and 191-210 568708014617 Signal peptide predicted for STM_MW32171 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.408 between residues 33 and 34 568708014618 PAS fold; Region: PAS_3; pfam08447 568708014619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568708014620 putative active site [active] 568708014621 heme pocket [chemical binding]; other site 568708014622 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 568708014623 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568708014624 dimer interface [polypeptide binding]; other site 568708014625 putative CheW interface [polypeptide binding]; other site 568708014628 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 568708014629 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568708014630 inhibitor-cofactor binding pocket; inhibition site 568708014631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708014632 catalytic residue [active] 568708014634 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568708014635 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 568708014636 active site 568708014637 FMN binding site [chemical binding]; other site 568708014638 2,4-decadienoyl-CoA binding site; other site 568708014639 catalytic residue [active] 568708014640 4Fe-4S cluster binding site [ion binding]; other site 568708014641 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 568708014642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568708014646 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 568708014647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708014648 S-adenosylmethionine binding site [chemical binding]; other site 568708014650 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 568708014652 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568708014653 putative active site [active] 568708014654 Signal peptide predicted for STM_MW32231 by SignalP 2.0 HMM (Signal peptide probability 0.792) with cleavage site probability 0.231 between residues 43 and 44 568708014655 1 probable transmembrane helix predicted for STM_MW32231 by TMHMM2.0 at aa 19-41 568708014657 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568708014658 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568708014660 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 568708014661 9 probable transmembrane helices predicted for STM_MW32251 by TMHMM2.0 at aa 10-29, 42-64, 79-101, 114-136, 142-161, 198-220, 235-257, 264-286 and 290-312 568708014663 serine/threonine transporter SstT; Provisional; Region: PRK13628 568708014664 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 568708014665 8 probable transmembrane helices predicted for STM_MW32261 by TMHMM2.0 at aa 13-35, 50-72, 84-106, 141-163, 191-213, 218-240, 292-314 and 329-351 568708014667 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568708014668 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 568708014669 6 probable transmembrane helices predicted for STM_MW32271 by TMHMM2.0 at aa 19-38, 42-64, 71-93, 126-148, 153-175 and 190-212 568708014671 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 568708014672 Signal peptide predicted for STM_MW32281 by SignalP 2.0 HMM (Signal peptide probability 0.928) with cleavage site probability 0.396 between residues 34 and 35 568708014673 1 probable transmembrane helix predicted for STM_MW32281 by TMHMM2.0 at aa 12-31 568708014674 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 568708014675 Signal peptide predicted for STM_MW32291 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.959 between residues 20 and 21 568708014677 Predicted membrane protein [Function unknown]; Region: COG5393 568708014679 2 probable transmembrane helices predicted for STM_MW32301 by TMHMM2.0 at aa 50-72 and 82-104 568708014680 YqjK-like protein; Region: YqjK; pfam13997 568708014681 Predicted membrane protein [Function unknown]; Region: COG2259 568708014683 4 probable transmembrane helices predicted for STM_MW32321 by TMHMM2.0 at aa 40-62, 77-99, 104-121 and 136-153 568708014684 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 568708014685 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 568708014686 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 568708014687 putative dimer interface [polypeptide binding]; other site 568708014688 N-terminal domain interface [polypeptide binding]; other site 568708014689 putative substrate binding pocket (H-site) [chemical binding]; other site 568708014691 Predicted membrane protein [Function unknown]; Region: COG3152 568708014693 3 probable transmembrane helices predicted for STM_MW32341 by TMHMM2.0 at aa 24-46, 51-70 and 82-101 568708014694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708014695 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 568708014696 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568708014697 dimerization interface [polypeptide binding]; other site 568708014700 Pirin-related protein [General function prediction only]; Region: COG1741 568708014701 Pirin; Region: Pirin; pfam02678 568708014703 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 568708014705 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 568708014706 serine transporter; Region: stp; TIGR00814 568708014707 11 probable transmembrane helices predicted for STM_MW32391 by TMHMM2.0 at aa 38-60, 65-87, 112-134, 149-171, 184-206, 221-243, 264-286, 318-340, 363-385, 389-411 and 423-442 568708014708 L-serine dehydratase TdcG; Provisional; Region: PRK15040 568708014709 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 568708014710 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 568708014713 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 568708014714 Pyruvate formate lyase 1; Region: PFL1; cd01678 568708014715 coenzyme A binding site [chemical binding]; other site 568708014716 active site 568708014717 catalytic residues [active] 568708014718 glycine loop; other site 568708014721 propionate/acetate kinase; Provisional; Region: PRK12379 568708014722 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 568708014724 threonine/serine transporter TdcC; Provisional; Region: PRK13629 568708014725 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 568708014726 11 probable transmembrane helices predicted for STM_MW32431 by TMHMM2.0 at aa 23-40, 44-66, 97-119, 134-156, 163-185, 212-234, 255-277, 315-337, 358-380, 390-409 and 422-440 568708014728 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 568708014729 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 568708014730 tetramer interface [polypeptide binding]; other site 568708014731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708014732 catalytic residue [active] 568708014734 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 568708014735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708014736 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 568708014737 putative substrate binding pocket [chemical binding]; other site 568708014738 putative dimerization interface [polypeptide binding]; other site 568708014741 glycerate kinase I; Provisional; Region: PRK10342 568708014743 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 568708014744 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568708014746 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 568708014748 galactarate dehydratase; Region: galactar-dH20; TIGR03248 568708014749 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 568708014750 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 568708014753 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568708014754 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568708014755 substrate binding site [chemical binding]; other site 568708014756 ATP binding site [chemical binding]; other site 568708014758 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568708014759 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568708014760 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708014763 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568708014764 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 568708014765 intersubunit interface [polypeptide binding]; other site 568708014766 active site 568708014767 zinc binding site [ion binding]; other site 568708014768 Na+ binding site [ion binding]; other site 568708014770 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 568708014771 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568708014772 putative substrate binding site [chemical binding]; other site 568708014773 putative ATP binding site [chemical binding]; other site 568708014775 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 568708014776 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568708014777 active site 568708014778 P-loop; other site 568708014779 phosphorylation site [posttranslational modification] 568708014780 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 568708014783 8 probable transmembrane helices predicted for STM_MW32551 by TMHMM2.0 at aa 133-155, 175-197, 209-231, 251-270, 291-310, 330-352, 391-413 and 428-450 568708014784 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568708014785 active site 568708014786 phosphorylation site [posttranslational modification] 568708014787 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568708014788 dimerization domain swap beta strand [polypeptide binding]; other site 568708014789 regulatory protein interface [polypeptide binding]; other site 568708014790 active site 568708014791 regulatory phosphorylation site [posttranslational modification]; other site 568708014794 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 568708014796 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568708014797 active site 568708014798 phosphorylation site [posttranslational modification] 568708014800 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 568708014801 active site 568708014802 P-loop; other site 568708014803 phosphorylation site [posttranslational modification] 568708014804 Signal peptide predicted for STM_MW32591 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 568708014806 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 568708014807 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568708014808 9 probable transmembrane helices predicted for STM_MW32601 by TMHMM2.0 at aa 4-26, 39-61, 91-113, 134-156, 225-247, 299-321, 331-348, 353-375 and 411-433 568708014810 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 568708014811 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 568708014812 putative NAD(P) binding site [chemical binding]; other site 568708014813 catalytic Zn binding site [ion binding]; other site 568708014816 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568708014817 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568708014818 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708014821 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 568708014822 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 568708014823 putative SAM binding site [chemical binding]; other site 568708014824 putative homodimer interface [polypeptide binding]; other site 568708014826 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568708014827 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 568708014828 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 568708014829 putative ligand binding site [chemical binding]; other site 568708014830 Signal peptide predicted for STM_MW32641 by SignalP 2.0 HMM (Signal peptide probability 0.840) with cleavage site probability 0.396 between residues 30 and 31 568708014832 TIGR00252 family protein; Region: TIGR00252 568708014834 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 568708014835 dimer interface [polypeptide binding]; other site 568708014836 active site 568708014838 outer membrane lipoprotein; Provisional; Region: PRK11023 568708014839 BON domain; Region: BON; pfam04972 568708014840 BON domain; Region: BON; pfam04972 568708014841 Signal peptide predicted for STM_MW32671 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.540 between residues 22 and 23 568708014842 1 probable transmembrane helix predicted for STM_MW32671 by TMHMM2.0 at aa 7-29 568708014844 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 568708014845 NADH(P)-binding; Region: NAD_binding_10; pfam13460 568708014846 NAD binding site [chemical binding]; other site 568708014847 active site 568708014849 intracellular protease, PfpI family; Region: PfpI; TIGR01382 568708014850 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 568708014851 proposed catalytic triad [active] 568708014852 conserved cys residue [active] 568708014854 hypothetical protein; Provisional; Region: PRK03467 568708014855 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 568708014856 GIY-YIG motif/motif A; other site 568708014857 putative active site [active] 568708014858 putative metal binding site [ion binding]; other site 568708014860 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568708014861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708014862 Coenzyme A binding pocket [chemical binding]; other site 568708014864 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 568708014866 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 568708014867 Peptidase family U32; Region: Peptidase_U32; pfam01136 568708014869 putative protease; Provisional; Region: PRK15447 568708014870 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 568708014872 hypothetical protein; Provisional; Region: PRK10508 568708014873 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 568708014875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 568708014877 1 probable transmembrane helix predicted for STM_MW32771 by TMHMM2.0 at aa 5-27 568708014878 tryptophan permease; Provisional; Region: PRK10483 568708014879 aromatic amino acid transport protein; Region: araaP; TIGR00837 568708014881 10 probable transmembrane helices predicted for STM_MW32791 by TMHMM2.0 at aa 10-32, 59-81, 96-118, 125-147, 162-184, 197-219, 256-278, 290-312, 317-339 and 360-382 568708014882 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568708014883 DEAD-like helicases superfamily; Region: DEXDc; smart00487 568708014884 ATP binding site [chemical binding]; other site 568708014885 Mg++ binding site [ion binding]; other site 568708014886 motif III; other site 568708014887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708014888 nucleotide binding region [chemical binding]; other site 568708014889 ATP-binding site [chemical binding]; other site 568708014890 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 568708014891 putative RNA binding site [nucleotide binding]; other site 568708014895 lipoprotein NlpI; Provisional; Region: PRK11189 568708014896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568708014897 binding surface 568708014898 TPR motif; other site 568708014900 Signal peptide predicted for STM_MW32811 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.958 between residues 22 and 23 568708014901 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 568708014902 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 568708014903 RNase E interface [polypeptide binding]; other site 568708014904 trimer interface [polypeptide binding]; other site 568708014905 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 568708014906 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 568708014907 RNase E interface [polypeptide binding]; other site 568708014908 trimer interface [polypeptide binding]; other site 568708014909 active site 568708014910 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 568708014911 putative nucleic acid binding region [nucleotide binding]; other site 568708014912 G-X-X-G motif; other site 568708014913 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 568708014914 RNA binding site [nucleotide binding]; other site 568708014915 domain interface; other site 568708014921 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 568708014922 16S/18S rRNA binding site [nucleotide binding]; other site 568708014923 S13e-L30e interaction site [polypeptide binding]; other site 568708014924 25S rRNA binding site [nucleotide binding]; other site 568708014926 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 568708014927 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 568708014928 RNA binding site [nucleotide binding]; other site 568708014929 active site 568708014930 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 568708014933 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 568708014935 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568708014936 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 568708014937 translation initiation factor IF-2; Region: IF-2; TIGR00487 568708014938 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568708014939 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 568708014940 G1 box; other site 568708014941 putative GEF interaction site [polypeptide binding]; other site 568708014942 GTP/Mg2+ binding site [chemical binding]; other site 568708014943 Switch I region; other site 568708014944 G2 box; other site 568708014945 G3 box; other site 568708014946 Switch II region; other site 568708014947 G4 box; other site 568708014948 G5 box; other site 568708014949 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 568708014950 Translation-initiation factor 2; Region: IF-2; pfam11987 568708014951 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 568708014957 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 568708014958 NusA N-terminal domain; Region: NusA_N; pfam08529 568708014959 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 568708014960 RNA binding site [nucleotide binding]; other site 568708014961 homodimer interface [polypeptide binding]; other site 568708014962 NusA-like KH domain; Region: KH_5; pfam13184 568708014963 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 568708014964 G-X-X-G motif; other site 568708014965 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 568708014966 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 568708014969 ribosome maturation protein RimP; Reviewed; Region: PRK00092 568708014970 hypothetical protein; Provisional; Region: PRK14641 568708014971 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 568708014972 putative oligomer interface [polypeptide binding]; other site 568708014973 putative RNA binding site [nucleotide binding]; other site 568708014975 argininosuccinate synthase; Validated; Region: PRK05370 568708014976 argininosuccinate synthase; Provisional; Region: PRK13820 568708014978 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 568708014980 Preprotein translocase SecG subunit; Region: SecG; pfam03840 568708014982 2 probable transmembrane helices predicted for STM_MW32911 by TMHMM2.0 at aa 5-22 and 51-73 568708014983 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 568708014984 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 568708014985 active site 568708014986 substrate binding site [chemical binding]; other site 568708014987 metal binding site [ion binding]; metal-binding site 568708014992 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 568708014993 dihydropteroate synthase; Region: DHPS; TIGR01496 568708014994 substrate binding pocket [chemical binding]; other site 568708014995 dimer interface [polypeptide binding]; other site 568708014996 inhibitor binding site; inhibition site 568708014998 Transposase IS200 like; Region: Y1_Tnp; pfam01797 568708015000 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 568708015001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708015002 Walker A motif; other site 568708015003 ATP binding site [chemical binding]; other site 568708015004 Walker B motif; other site 568708015005 arginine finger; other site 568708015006 Peptidase family M41; Region: Peptidase_M41; pfam01434 568708015010 2 probable transmembrane helices predicted for STM_MW32951 by TMHMM2.0 at aa 5-24 and 97-119 568708015011 Signal peptide predicted for STM_MW32951 by SignalP 2.0 HMM (Signal peptide probability 0.701) with cleavage site probability 0.380 between residues 27 and 28 568708015012 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 568708015013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708015014 S-adenosylmethionine binding site [chemical binding]; other site 568708015016 RNA-binding protein YhbY; Provisional; Region: PRK10343 568708015018 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 568708015019 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 568708015020 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568708015023 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 568708015024 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 568708015025 Signal peptide predicted for STM_MW32991 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 20 and 21 568708015027 GTPase CgtA; Reviewed; Region: obgE; PRK12298 568708015028 GTP1/OBG; Region: GTP1_OBG; pfam01018 568708015029 Obg GTPase; Region: Obg; cd01898 568708015030 G1 box; other site 568708015031 GTP/Mg2+ binding site [chemical binding]; other site 568708015032 Switch I region; other site 568708015033 G2 box; other site 568708015034 G3 box; other site 568708015035 Switch II region; other site 568708015036 G4 box; other site 568708015037 G5 box; other site 568708015041 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568708015042 EamA-like transporter family; Region: EamA; pfam00892 568708015043 EamA-like transporter family; Region: EamA; pfam00892 568708015044 10 probable transmembrane helices predicted for STM_MW33011 by TMHMM2.0 at aa 20-39, 54-73, 86-108, 118-135, 144-166, 170-192, 205-227, 232-254, 261-283 and 293-315 568708015046 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 568708015048 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 568708015049 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 568708015051 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568708015052 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568708015053 substrate binding pocket [chemical binding]; other site 568708015054 chain length determination region; other site 568708015055 substrate-Mg2+ binding site; other site 568708015056 catalytic residues [active] 568708015057 aspartate-rich region 1; other site 568708015058 active site lid residues [active] 568708015059 aspartate-rich region 2; other site 568708015061 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 568708015062 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 568708015063 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 568708015064 hinge; other site 568708015065 active site 568708015067 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 568708015069 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 568708015070 anti sigma factor interaction site; other site 568708015071 regulatory phosphorylation site [posttranslational modification]; other site 568708015073 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 568708015075 Signal peptide predicted for STM_MW33091 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.861 between residues 21 and 22 568708015076 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 568708015077 mce related protein; Region: MCE; pfam02470 568708015079 1 probable transmembrane helix predicted for STM_MW33101 by TMHMM2.0 at aa 9-31 568708015080 Signal peptide predicted for STM_MW33101 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.870 between residues 28 and 29 568708015081 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 568708015082 conserved hypothetical integral membrane protein; Region: TIGR00056 568708015083 5 probable transmembrane helices predicted for STM_MW33111 by TMHMM2.0 at aa 48-70, 85-107, 148-170, 197-219 and 239-258 568708015085 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 568708015086 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 568708015087 Walker A/P-loop; other site 568708015088 ATP binding site [chemical binding]; other site 568708015089 Q-loop/lid; other site 568708015090 ABC transporter signature motif; other site 568708015091 Walker B; other site 568708015092 D-loop; other site 568708015093 H-loop/switch region; other site 568708015095 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 568708015096 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 568708015097 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 568708015099 9 probable transmembrane helices predicted for STM_MW33131 by TMHMM2.0 at aa 13-35, 55-77, 86-105, 115-137, 158-180, 190-212, 225-247, 257-276 and 283-305 568708015100 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 568708015101 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 568708015102 putative active site [active] 568708015103 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 568708015106 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 568708015107 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 568708015109 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 568708015110 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 568708015111 Signal peptide predicted for STM_MW33161 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.708 between residues 25 and 26 568708015112 1 probable transmembrane helix predicted for STM_MW33161 by TMHMM2.0 at aa 7-25 568708015114 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 568708015115 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 568708015116 Signal peptide predicted for STM_MW33171 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.984 between residues 27 and 28 568708015118 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 568708015119 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 568708015120 Walker A/P-loop; other site 568708015121 ATP binding site [chemical binding]; other site 568708015122 Q-loop/lid; other site 568708015123 ABC transporter signature motif; other site 568708015124 Walker B; other site 568708015125 D-loop; other site 568708015126 H-loop/switch region; other site 568708015128 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 568708015129 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 568708015130 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 568708015131 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 568708015135 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 568708015136 30S subunit binding site; other site 568708015138 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568708015139 active site 568708015140 phosphorylation site [posttranslational modification] 568708015142 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 568708015144 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568708015145 dimerization domain swap beta strand [polypeptide binding]; other site 568708015146 regulatory protein interface [polypeptide binding]; other site 568708015147 active site 568708015148 regulatory phosphorylation site [posttranslational modification]; other site 568708015150 hypothetical protein; Provisional; Region: PRK10345 568708015152 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 568708015153 Transglycosylase; Region: Transgly; cl17702 568708015155 Signal peptide predicted for STM_MW33251 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.755 between residues 46 and 47 568708015156 1 probable transmembrane helix predicted for STM_MW33251 by TMHMM2.0 at aa 19-41 568708015157 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 568708015158 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 568708015159 conserved cys residue [active] 568708015161 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 568708015162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568708015163 putative active site [active] 568708015164 heme pocket [chemical binding]; other site 568708015165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708015166 dimer interface [polypeptide binding]; other site 568708015167 phosphorylation site [posttranslational modification] 568708015168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708015169 ATP binding site [chemical binding]; other site 568708015170 Mg2+ binding site [ion binding]; other site 568708015171 G-X-G motif; other site 568708015172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708015173 active site 568708015174 phosphorylation site [posttranslational modification] 568708015175 intermolecular recognition site; other site 568708015176 dimerization interface [polypeptide binding]; other site 568708015177 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 568708015178 putative binding surface; other site 568708015179 active site 568708015185 2 probable transmembrane helices predicted for STM_MW33271 by TMHMM2.0 at aa 20-42 and 55-77 568708015186 Signal peptide predicted for STM_MW33271 by SignalP 2.0 HMM (Signal peptide probability 0.907) with cleavage site probability 0.597 between residues 41 and 42 568708015187 radical SAM protein, TIGR01212 family; Region: TIGR01212 568708015188 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708015189 FeS/SAM binding site; other site 568708015191 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 568708015192 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 568708015193 active site 568708015194 dimer interface [polypeptide binding]; other site 568708015195 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 568708015196 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 568708015197 active site 568708015198 FMN binding site [chemical binding]; other site 568708015199 substrate binding site [chemical binding]; other site 568708015200 3Fe-4S cluster binding site [ion binding]; other site 568708015201 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 568708015202 domain interface; other site 568708015207 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 568708015208 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568708015209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568708015212 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 568708015213 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 568708015215 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 568708015216 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 568708015217 Na binding site [ion binding]; other site 568708015218 putative substrate binding site [chemical binding]; other site 568708015220 12 probable transmembrane helices predicted for STM_MW33321 by TMHMM2.0 at aa 21-43, 53-75, 96-118, 128-150, 152-174, 189-211, 223-245, 255-277, 296-318, 323-345, 358-375 and 380-402 568708015221 cytosine deaminase; Provisional; Region: PRK09230 568708015222 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 568708015223 active site 568708015225 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 568708015227 N-acetylmannosamine kinase; Provisional; Region: PRK05082 568708015228 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568708015229 nucleotide binding site [chemical binding]; other site 568708015231 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 568708015232 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 568708015233 putative active site cavity [active] 568708015235 putative sialic acid transporter; Provisional; Region: PRK03893 568708015236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708015237 putative substrate translocation pore; other site 568708015239 14 probable transmembrane helices predicted for STM_MW33371 by TMHMM2.0 at aa 20-42, 57-79, 86-108, 112-134, 147-166, 171-190, 224-243, 248-267, 280-302, 312-334, 347-369, 373-395, 404-426 and 431-453 568708015240 N-acetylneuraminate lyase; Provisional; Region: PRK04147 568708015241 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 568708015242 inhibitor site; inhibition site 568708015243 active site 568708015244 dimer interface [polypeptide binding]; other site 568708015245 catalytic residue [active] 568708015247 transcriptional regulator NanR; Provisional; Region: PRK03837 568708015248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708015249 DNA-binding site [nucleotide binding]; DNA binding site 568708015250 FCD domain; Region: FCD; pfam07729 568708015253 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 568708015255 stringent starvation protein A; Provisional; Region: sspA; PRK09481 568708015256 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 568708015257 C-terminal domain interface [polypeptide binding]; other site 568708015258 putative GSH binding site (G-site) [chemical binding]; other site 568708015259 dimer interface [polypeptide binding]; other site 568708015260 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 568708015261 dimer interface [polypeptide binding]; other site 568708015262 N-terminal domain interface [polypeptide binding]; other site 568708015265 Family of unknown function (DUF695); Region: DUF695; pfam05117 568708015266 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 568708015269 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 568708015271 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 568708015272 23S rRNA interface [nucleotide binding]; other site 568708015273 L3 interface [polypeptide binding]; other site 568708015275 Predicted ATPase [General function prediction only]; Region: COG1485 568708015277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 568708015278 hypothetical protein; Provisional; Region: PRK11677 568708015279 1 probable transmembrane helix predicted for STM_MW33461 by TMHMM2.0 at aa 4-26 568708015281 serine endoprotease; Provisional; Region: PRK10139 568708015282 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 568708015283 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568708015284 protein binding site [polypeptide binding]; other site 568708015285 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568708015286 Signal peptide predicted for STM_MW33471 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 27 and 28 568708015287 1 probable transmembrane helix predicted for STM_MW33471 by TMHMM2.0 at aa 7-29 568708015290 serine endoprotease; Provisional; Region: PRK10898 568708015291 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 568708015292 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568708015293 Signal peptide predicted for STM_MW33481 by SignalP 2.0 HMM (Signal peptide probability 0.600) with cleavage site probability 0.341 between residues 21 and 22 568708015294 1 probable transmembrane helix predicted for STM_MW33481 by TMHMM2.0 at aa 5-27 568708015297 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 568708015299 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 568708015300 9 probable transmembrane helices predicted for STM_MW33501 by TMHMM2.0 at aa 13-35, 122-144, 159-178, 180-202, 222-244, 266-288, 308-327, 339-361 and 413-432 568708015302 oxaloacetate decarboxylase; Provisional; Region: PRK14040 568708015303 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 568708015304 active site 568708015305 catalytic residues [active] 568708015306 metal binding site [ion binding]; metal-binding site 568708015307 homodimer binding site [polypeptide binding]; other site 568708015308 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568708015309 carboxyltransferase (CT) interaction site; other site 568708015310 biotinylation site [posttranslational modification]; other site 568708015314 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 568708015316 pfam_scan;Pfam:PF05681; E()=4.0E-78;score=261.8;query 10-281;description=Fumerase 568708015318 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 568708015319 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 568708015320 transmembrane helices; other site 568708015321 11 probable transmembrane helices predicted for STM_MW33541 by TMHMM2.0 at aa 4-20, 25-44, 49-71, 92-121, 136-158, 171-193, 244-266, 279-301, 316-338, 359-378 and 398-420 568708015323 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568708015324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708015325 DNA-binding site [nucleotide binding]; DNA binding site 568708015326 FCD domain; Region: FCD; pfam07729 568708015329 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568708015330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708015331 DNA-binding site [nucleotide binding]; DNA binding site 568708015334 malate dehydrogenase; Provisional; Region: PRK05086 568708015335 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 568708015336 NAD binding site [chemical binding]; other site 568708015337 dimerization interface [polypeptide binding]; other site 568708015338 Substrate binding site [chemical binding]; other site 568708015341 arginine repressor; Provisional; Region: PRK05066 568708015342 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 568708015343 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 568708015346 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 568708015347 Signal peptide predicted for STM_MW33591 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708015349 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 568708015350 Signal peptide predicted for STM_MW33601 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.961 between residues 22 and 23 568708015351 1 probable transmembrane helix predicted for STM_MW33601 by TMHMM2.0 at aa 5-24 568708015353 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 568708015354 RNAase interaction site [polypeptide binding]; other site 568708015356 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 568708015357 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 568708015359 10 probable transmembrane helices predicted for STM_MW33621 by TMHMM2.0 at aa 13-33, 38-60, 67-89, 93-112, 119-136, 151-168, 370-392, 407-426, 433-452 and 481-503 568708015360 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 568708015361 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568708015362 HlyD family secretion protein; Region: HlyD_3; pfam13437 568708015364 1 probable transmembrane helix predicted for STM_MW33631 by TMHMM2.0 at aa 12-31 568708015365 Signal peptide predicted for STM_MW33631 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.885 between residues 30 and 31 568708015366 efflux system membrane protein; Provisional; Region: PRK11594 568708015367 2 probable transmembrane helices predicted for STM_MW33641 by TMHMM2.0 at aa 7-29 and 44-66 568708015369 transcriptional regulator; Provisional; Region: PRK10632 568708015370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708015371 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568708015372 putative effector binding pocket; other site 568708015373 dimerization interface [polypeptide binding]; other site 568708015376 protease TldD; Provisional; Region: tldD; PRK10735 568708015378 hypothetical protein; Provisional; Region: PRK10899 568708015379 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 568708015380 ribonuclease G; Provisional; Region: PRK11712 568708015381 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 568708015382 homodimer interface [polypeptide binding]; other site 568708015383 oligonucleotide binding site [chemical binding]; other site 568708015386 Maf-like protein; Region: Maf; pfam02545 568708015387 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 568708015388 active site 568708015389 dimer interface [polypeptide binding]; other site 568708015391 rod shape-determining protein MreD; Provisional; Region: PRK11060 568708015393 5 probable transmembrane helices predicted for STM_MW33701 by TMHMM2.0 at aa 11-28, 32-51, 58-80, 100-122 and 135-152 568708015394 rod shape-determining protein MreC; Region: mreC; TIGR00219 568708015395 rod shape-determining protein MreC; Region: MreC; pfam04085 568708015397 1 probable transmembrane helix predicted for STM_MW33711 by TMHMM2.0 at aa 13-35 568708015398 rod shape-determining protein MreB; Provisional; Region: PRK13927 568708015399 MreB and similar proteins; Region: MreB_like; cd10225 568708015400 nucleotide binding site [chemical binding]; other site 568708015401 Mg binding site [ion binding]; other site 568708015402 putative protofilament interaction site [polypeptide binding]; other site 568708015403 RodZ interaction site [polypeptide binding]; other site 568708015405 regulatory protein CsrD; Provisional; Region: PRK11059 568708015406 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568708015407 metal binding site [ion binding]; metal-binding site 568708015408 active site 568708015409 I-site; other site 568708015410 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708015413 2 probable transmembrane helices predicted for STM_MW33731 by TMHMM2.0 at aa 10-32 and 130-152 568708015414 Signal peptide predicted for STM_MW33731 by SignalP 2.0 HMM (Signal peptide probability 0.951) with cleavage site probability 0.693 between residues 33 and 34 568708015415 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 568708015416 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 568708015417 NADP binding site [chemical binding]; other site 568708015418 dimer interface [polypeptide binding]; other site 568708015421 TMAO/DMSO reductase; Reviewed; Region: PRK05363 568708015422 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 568708015423 Moco binding site; other site 568708015424 metal coordination site [ion binding]; other site 568708015426 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 568708015427 6 probable transmembrane helices predicted for STM_MW33761 by TMHMM2.0 at aa 13-30, 45-67, 80-102, 117-139, 151-168 and 172-189 568708015429 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 568708015430 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568708015431 carboxyltransferase (CT) interaction site; other site 568708015432 biotinylation site [posttranslational modification]; other site 568708015434 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 568708015435 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568708015436 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568708015437 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568708015441 hypothetical protein; Provisional; Region: PRK10633 568708015443 2 probable transmembrane helices predicted for STM_MW33791 by TMHMM2.0 at aa 13-32 and 42-64 568708015444 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 568708015445 Na binding site [ion binding]; other site 568708015446 13 probable transmembrane helices predicted for STM_MW33801 by TMHMM2.0 at aa 5-24, 37-59, 72-94, 123-145, 160-182, 189-211, 233-255, 268-290, 319-341, 369-386, 391-413, 420-442 and 447-466 568708015448 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 568708015449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 568708015451 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 568708015452 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 568708015453 FMN binding site [chemical binding]; other site 568708015454 active site 568708015455 catalytic residues [active] 568708015456 substrate binding site [chemical binding]; other site 568708015458 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 568708015459 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 568708015461 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 568708015462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708015463 DNA methylase; Region: N6_N4_Mtase; pfam01555 568708015465 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 568708015467 1 probable transmembrane helix predicted for STM_MW33851 by TMHMM2.0 at aa 7-29 568708015468 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 568708015469 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 568708015470 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 568708015471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568708015472 metal binding site [ion binding]; metal-binding site 568708015473 active site 568708015474 I-site; other site 568708015475 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708015476 7 probable transmembrane helices predicted for STM_MW33861 by TMHMM2.0 at aa 10-27, 40-62, 77-99, 112-134, 139-161, 174-193 and 213-235 568708015480 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 568708015481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708015482 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 568708015485 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 568708015486 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568708015487 HlyD family secretion protein; Region: HlyD_3; pfam13437 568708015488 Signal peptide predicted for STM_MW33891 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.671 between residues 22 and 23 568708015490 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 568708015491 Signal peptide predicted for STM_MW33901 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.692 between residues 26 and 27 568708015493 12 probable transmembrane helices predicted for STM_MW33901 by TMHMM2.0 at aa 9-31, 337-359, 366-388, 392-414, 438-460, 470-492, 541-563, 872-891, 898-920, 925-947, 974-996 and 1006-1028 568708015494 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 568708015495 Signal peptide predicted for STM_MW33911 by SignalP 2.0 HMM (Signal peptide probability 0.904) with cleavage site probability 0.903 between residues 18 and 19 568708015497 1 probable transmembrane helix predicted for STM_MW33911 by TMHMM2.0 at aa 50-72 568708015498 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 568708015499 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 568708015500 trimer interface [polypeptide binding]; other site 568708015501 putative metal binding site [ion binding]; other site 568708015502 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 568708015504 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 568708015505 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568708015506 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568708015507 shikimate binding site; other site 568708015508 NAD(P) binding site [chemical binding]; other site 568708015511 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 568708015513 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 568708015514 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 568708015515 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 568708015516 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 568708015518 hypothetical protein; Validated; Region: PRK03430 568708015520 hypothetical protein; Provisional; Region: PRK10736 568708015521 DNA protecting protein DprA; Region: dprA; TIGR00732 568708015523 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 568708015524 active site 568708015525 catalytic residues [active] 568708015526 metal binding site [ion binding]; metal-binding site 568708015528 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 568708015529 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 568708015530 putative active site [active] 568708015531 substrate binding site [chemical binding]; other site 568708015532 putative cosubstrate binding site; other site 568708015533 catalytic site [active] 568708015534 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 568708015535 substrate binding site [chemical binding]; other site 568708015538 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 568708015539 putative RNA binding site [nucleotide binding]; other site 568708015540 16S rRNA methyltransferase B; Provisional; Region: PRK10901 568708015541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708015542 S-adenosylmethionine binding site [chemical binding]; other site 568708015545 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 568708015546 TrkA-N domain; Region: TrkA_N; pfam02254 568708015547 TrkA-C domain; Region: TrkA_C; pfam02080 568708015548 TrkA-N domain; Region: TrkA_N; pfam02254 568708015549 TrkA-C domain; Region: TrkA_C; pfam02080 568708015552 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 568708015553 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 568708015555 2 probable transmembrane helices predicted for STM_MW34031 by TMHMM2.0 at aa 20-42 and 77-99 568708015556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 568708015558 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 568708015559 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 568708015560 DNA binding residues [nucleotide binding] 568708015561 dimer interface [polypeptide binding]; other site 568708015562 metal binding site [ion binding]; metal-binding site 568708015565 hypothetical protein; Provisional; Region: PRK10203 568708015567 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 568708015569 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 568708015570 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 568708015571 alphaNTD homodimer interface [polypeptide binding]; other site 568708015572 alphaNTD - beta interaction site [polypeptide binding]; other site 568708015573 alphaNTD - beta' interaction site [polypeptide binding]; other site 568708015574 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 568708015578 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 568708015579 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 568708015580 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568708015581 RNA binding surface [nucleotide binding]; other site 568708015584 30S ribosomal protein S11; Validated; Region: PRK05309 568708015586 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 568708015587 30S ribosomal protein S13; Region: bact_S13; TIGR03631 568708015589 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 568708015591 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 568708015592 SecY translocase; Region: SecY; pfam00344 568708015593 10 probable transmembrane helices predicted for STM_MW34131 by TMHMM2.0 at aa 22-44, 76-98, 119-138, 153-175, 182-204, 215-237, 274-296, 316-338, 373-392 and 397-414 568708015595 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 568708015597 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 568708015598 23S rRNA binding site [nucleotide binding]; other site 568708015600 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 568708015601 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 568708015602 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 568708015605 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 568708015606 23S rRNA interface [nucleotide binding]; other site 568708015607 5S rRNA interface [nucleotide binding]; other site 568708015608 L27 interface [polypeptide binding]; other site 568708015609 L5 interface [polypeptide binding]; other site 568708015611 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 568708015612 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568708015613 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568708015615 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 568708015617 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 568708015619 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 568708015620 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 568708015621 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 568708015624 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 568708015625 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 568708015626 RNA binding site [nucleotide binding]; other site 568708015628 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 568708015630 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 568708015632 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 568708015633 23S rRNA interface [nucleotide binding]; other site 568708015634 5S rRNA interface [nucleotide binding]; other site 568708015635 putative antibiotic binding site [chemical binding]; other site 568708015636 L25 interface [polypeptide binding]; other site 568708015637 L27 interface [polypeptide binding]; other site 568708015639 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 568708015640 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 568708015641 G-X-X-G motif; other site 568708015642 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 568708015646 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 568708015647 protein-rRNA interface [nucleotide binding]; other site 568708015648 putative translocon binding site; other site 568708015650 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 568708015652 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 568708015653 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 568708015654 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 568708015657 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 568708015659 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 568708015661 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 568708015663 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 568708015665 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 568708015666 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 568708015667 4 probable transmembrane helices predicted for STM_MW34341 by TMHMM2.0 at aa 4-21, 55-74, 101-123 and 130-152 568708015669 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 568708015670 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 568708015671 heme binding site [chemical binding]; other site 568708015672 ferroxidase pore; other site 568708015673 ferroxidase diiron center [ion binding]; other site 568708015675 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 568708015677 elongation factor Tu; Reviewed; Region: PRK00049 568708015678 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 568708015679 G1 box; other site 568708015680 GEF interaction site [polypeptide binding]; other site 568708015681 GTP/Mg2+ binding site [chemical binding]; other site 568708015682 Switch I region; other site 568708015683 G2 box; other site 568708015684 G3 box; other site 568708015685 Switch II region; other site 568708015686 G4 box; other site 568708015687 G5 box; other site 568708015688 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 568708015689 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 568708015690 Antibiotic Binding Site [chemical binding]; other site 568708015694 elongation factor G; Reviewed; Region: PRK00007 568708015695 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 568708015696 G1 box; other site 568708015697 putative GEF interaction site [polypeptide binding]; other site 568708015698 GTP/Mg2+ binding site [chemical binding]; other site 568708015699 Switch I region; other site 568708015700 G2 box; other site 568708015701 G3 box; other site 568708015702 Switch II region; other site 568708015703 G4 box; other site 568708015704 G5 box; other site 568708015705 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 568708015706 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 568708015707 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 568708015712 30S ribosomal protein S7; Validated; Region: PRK05302 568708015714 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 568708015715 S17 interaction site [polypeptide binding]; other site 568708015716 S8 interaction site; other site 568708015717 16S rRNA interaction site [nucleotide binding]; other site 568708015718 streptomycin interaction site [chemical binding]; other site 568708015719 23S rRNA interaction site [nucleotide binding]; other site 568708015720 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 568708015722 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 568708015724 sulfur relay protein TusC; Validated; Region: PRK00211 568708015726 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 568708015728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 568708015729 YheO-like PAS domain; Region: PAS_6; pfam08348 568708015730 HTH domain; Region: HTH_22; pfam13309 568708015732 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 568708015733 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 568708015734 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 568708015737 Signal peptide predicted for STM_MW34451 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.976 between residues 25 and 26 568708015738 phi X174 lysis protein; Provisional; Region: PRK02793 568708015740 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 568708015741 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 568708015743 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 568708015745 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 568708015746 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 568708015747 TrkA-N domain; Region: TrkA_N; pfam02254 568708015749 10 probable transmembrane helices predicted for STM_MW34491 by TMHMM2.0 at aa 6-25, 32-51, 56-75, 87-109, 113-135, 148-170, 180-202, 223-245, 265-287 and 294-316 568708015751 Signal peptide predicted for STM_MW34491 by SignalP 2.0 HMM (Signal peptide probability 0.876) with cleavage site probability 0.309 between residues 19 and 20 568708015752 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 568708015754 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 568708015755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708015756 Walker A/P-loop; other site 568708015757 ATP binding site [chemical binding]; other site 568708015758 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568708015759 ABC transporter signature motif; other site 568708015760 Walker B; other site 568708015761 D-loop; other site 568708015762 ABC transporter; Region: ABC_tran_2; pfam12848 568708015763 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568708015765 putative monooxygenase; Provisional; Region: PRK11118 568708015767 putative hydrolase; Provisional; Region: PRK10985 568708015768 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 568708015770 hypothetical protein; Provisional; Region: PRK04966 568708015772 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 568708015773 active site 568708015774 Signal peptide predicted for STM_MW34551 by SignalP 2.0 HMM (Signal peptide probability 0.637) with cleavage site probability 0.588 between residues 24 and 25 568708015776 hypothetical protein; Provisional; Region: PRK10738 568708015778 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 568708015779 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568708015780 ligand binding site [chemical binding]; other site 568708015781 flexible hinge region; other site 568708015782 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 568708015783 putative switch regulator; other site 568708015784 non-specific DNA interactions [nucleotide binding]; other site 568708015785 DNA binding site [nucleotide binding] 568708015786 sequence specific DNA binding site [nucleotide binding]; other site 568708015787 putative cAMP binding site [chemical binding]; other site 568708015790 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 568708015791 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 568708015792 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 568708015793 8 probable transmembrane helices predicted for STM_MW34581 by TMHMM2.0 at aa 21-43, 78-100, 107-129, 134-156, 411-433, 437-453, 458-477 and 487-506 568708015794 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 568708015795 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568708015796 inhibitor-cofactor binding pocket; inhibition site 568708015797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708015798 catalytic residue [active] 568708015800 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 568708015801 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 568708015802 glutamine binding [chemical binding]; other site 568708015803 catalytic triad [active] 568708015805 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 568708015806 cell filamentation protein Fic; Provisional; Region: PRK10347 568708015808 hypothetical protein; Provisional; Region: PRK10204 568708015810 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 568708015811 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 568708015812 substrate binding site [chemical binding]; other site 568708015814 Signal peptide predicted for STM_MW34631 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 24 and 25 568708015815 putative transporter; Provisional; Region: PRK03699 568708015816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708015817 putative substrate translocation pore; other site 568708015818 Signal peptide predicted for STM_MW34641 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.985 between residues 32 and 33 568708015819 12 probable transmembrane helices predicted for STM_MW34641 by TMHMM2.0 at aa 12-34, 49-66, 78-95, 99-121, 134-156, 161-183, 204-226, 246-268, 273-292, 297-319, 332-354 and 359-381 568708015821 nitrite reductase subunit NirD; Provisional; Region: PRK14989 568708015822 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568708015823 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 568708015824 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 568708015825 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 568708015831 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 568708015832 nitrite transporter NirC; Provisional; Region: PRK11562 568708015834 6 probable transmembrane helices predicted for STM_MW34671 by TMHMM2.0 at aa 26-48, 58-80, 101-123, 150-172, 184-206 and 226-248 568708015835 siroheme synthase; Provisional; Region: cysG; PRK10637 568708015836 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 568708015837 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 568708015838 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 568708015839 active site 568708015840 SAM binding site [chemical binding]; other site 568708015841 homodimer interface [polypeptide binding]; other site 568708015844 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568708015845 Signal peptide predicted for STM_MW34691 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.960 between residues 27 and 28 568708015846 Transposase IS200 like; Region: Y1_Tnp; pfam01797 568708015848 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 568708015849 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 568708015850 active site 568708015851 HIGH motif; other site 568708015852 dimer interface [polypeptide binding]; other site 568708015853 KMSKS motif; other site 568708015855 phosphoglycolate phosphatase; Provisional; Region: PRK13222 568708015856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708015857 motif II; other site 568708015859 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 568708015860 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 568708015861 substrate binding site [chemical binding]; other site 568708015862 hexamer interface [polypeptide binding]; other site 568708015863 metal binding site [ion binding]; metal-binding site 568708015865 DNA adenine methylase; Provisional; Region: PRK10904 568708015867 cell division protein DamX; Validated; Region: PRK10905 568708015868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 568708015869 1 probable transmembrane helix predicted for STM_MW34751 by TMHMM2.0 at aa 93-115 568708015871 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 568708015872 active site 568708015873 dimer interface [polypeptide binding]; other site 568708015874 metal binding site [ion binding]; metal-binding site 568708015876 shikimate kinase; Reviewed; Region: aroK; PRK00131 568708015877 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 568708015878 ADP binding site [chemical binding]; other site 568708015879 magnesium binding site [ion binding]; other site 568708015880 putative shikimate binding site; other site 568708015882 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 568708015883 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 568708015887 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 568708015889 Signal peptide predicted for STM_MW34781 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.903 between residues 18 and 19 568708015890 1 probable transmembrane helix predicted for STM_MW34801 by TMHMM2.0 at aa 15-37 568708015891 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 568708015892 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 568708015894 1 probable transmembrane helix predicted for STM_MW34811 by TMHMM2.0 at aa 21-43 568708015895 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 568708015896 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 568708015897 Transglycosylase; Region: Transgly; pfam00912 568708015898 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 568708015899 Signal peptide predicted for STM_MW34831 by SignalP 2.0 HMM (Signal peptide probability 0.636) with cleavage site probability 0.493 between residues 32 and 33 568708015900 1 probable transmembrane helix predicted for STM_MW34831 by TMHMM2.0 at aa 12-34 568708015903 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 568708015904 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 568708015905 ADP-ribose binding site [chemical binding]; other site 568708015906 dimer interface [polypeptide binding]; other site 568708015907 active site 568708015908 nudix motif; other site 568708015909 metal binding site [ion binding]; metal-binding site 568708015911 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 568708015913 4 probable transmembrane helices predicted for STM_MW34851 by TMHMM2.0 at aa 157-176, 180-202, 291-313 and 607-629 568708015914 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 568708015915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708015916 motif II; other site 568708015918 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568708015919 RNA binding surface [nucleotide binding]; other site 568708015921 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 568708015922 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 568708015923 dimerization interface [polypeptide binding]; other site 568708015924 domain crossover interface; other site 568708015925 redox-dependent activation switch; other site 568708015927 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 568708015928 11 probable transmembrane helices predicted for STM_MW34891 by TMHMM2.0 at aa 12-34, 39-61, 66-84, 99-118, 138-160, 183-200, 213-235, 250-268, 281-303, 318-340 and 353-375 568708015929 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 568708015930 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 568708015931 active site 568708015932 substrate-binding site [chemical binding]; other site 568708015933 metal-binding site [ion binding] 568708015934 ATP binding site [chemical binding]; other site 568708015936 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 568708015937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708015938 dimerization interface [polypeptide binding]; other site 568708015939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708015940 dimer interface [polypeptide binding]; other site 568708015941 phosphorylation site [posttranslational modification] 568708015942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708015943 ATP binding site [chemical binding]; other site 568708015944 G-X-G motif; other site 568708015946 1 probable transmembrane helix predicted for STM_MW34911 by TMHMM2.0 at aa 121-140 568708015948 osmolarity response regulator; Provisional; Region: ompR; PRK09468 568708015949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708015950 active site 568708015951 phosphorylation site [posttranslational modification] 568708015952 intermolecular recognition site; other site 568708015953 dimerization interface [polypeptide binding]; other site 568708015954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708015955 DNA binding site [nucleotide binding] 568708015958 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 568708015959 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 568708015960 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568708015963 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 568708015964 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 568708015965 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 568708015966 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 568708015967 RNA binding site [nucleotide binding]; other site 568708015970 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 568708015972 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 568708015973 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 568708015974 G1 box; other site 568708015975 GTP/Mg2+ binding site [chemical binding]; other site 568708015976 Switch I region; other site 568708015977 G2 box; other site 568708015978 G3 box; other site 568708015979 Switch II region; other site 568708015980 G4 box; other site 568708015981 G5 box; other site 568708015982 Nucleoside recognition; Region: Gate; pfam07670 568708015983 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 568708015984 Nucleoside recognition; Region: Gate; pfam07670 568708015987 10 probable transmembrane helices predicted for STM_MW34961 by TMHMM2.0 at aa 277-299, 309-331, 344-366, 386-408, 429-447, 451-473, 510-532, 663-685, 692-714 and 720-742 568708015990 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 568708015992 hypothetical protein; Provisional; Region: PRK09956 568708015993 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 568708015995 carboxylesterase BioH; Provisional; Region: PRK10349 568708015996 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 568708015998 DNA utilization protein GntX; Provisional; Region: PRK11595 568708015999 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568708016000 active site 568708016002 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 568708016003 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 568708016004 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 568708016007 high-affinity gluconate transporter; Provisional; Region: PRK14984 568708016008 gluconate transporter; Region: gntP; TIGR00791 568708016009 Signal peptide predicted for STM_MW35021 by SignalP 2.0 HMM (Signal peptide probability 0.918) with cleavage site probability 0.567 between residues 23 and 24 568708016011 10 probable transmembrane helices predicted for STM_MW35021 by TMHMM2.0 at aa 7-27, 37-59, 80-98, 103-125, 159-181, 242-264, 277-296, 333-355, 362-384 and 399-421 568708016012 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 568708016013 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 568708016015 Signal peptide predicted for STM_MW35031 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.898 between residues 22 and 23 568708016016 maltodextrin phosphorylase; Provisional; Region: PRK14985 568708016017 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 568708016018 homodimer interface [polypeptide binding]; other site 568708016019 active site pocket [active] 568708016021 transcriptional regulator MalT; Provisional; Region: PRK04841 568708016022 AAA ATPase domain; Region: AAA_16; pfam13191 568708016023 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708016024 DNA binding residues [nucleotide binding] 568708016025 dimerization interface [polypeptide binding]; other site 568708016027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 568708016029 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 568708016031 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 568708016032 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 568708016033 putative active site [active] 568708016034 adenylation catalytic residue [active] 568708016037 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 568708016038 hypothetical protein; Reviewed; Region: PRK09588 568708016040 TROVE domain; Region: TROVE; pfam05731 568708016042 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 568708016043 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 568708016044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708016045 Walker A motif; other site 568708016046 ATP binding site [chemical binding]; other site 568708016047 Walker B motif; other site 568708016048 arginine finger; other site 568708016051 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 568708016052 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 568708016053 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708016056 intramembrane serine protease GlpG; Provisional; Region: PRK10907 568708016057 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 568708016058 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 568708016059 6 probable transmembrane helices predicted for STM_MW35131 by TMHMM2.0 at aa 98-120, 140-162, 169-188, 192-214, 223-245 and 250-272 568708016061 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 568708016062 active site residue [active] 568708016064 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 568708016066 hypothetical protein; Provisional; Region: PRK09781 568708016067 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 568708016068 5 probable transmembrane helices predicted for STM_MW35171 by TMHMM2.0 at aa 27-58, 73-95, 108-127, 160-182 and 195-217 568708016069 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 568708016070 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 568708016071 dimer interface [polypeptide binding]; other site 568708016072 active site 568708016073 metal binding site [ion binding]; metal-binding site 568708016075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708016076 D-galactonate transporter; Region: 2A0114; TIGR00893 568708016077 putative substrate translocation pore; other site 568708016078 12 probable transmembrane helices predicted for STM_MW35191 by TMHMM2.0 at aa 13-30, 50-72, 85-104, 109-131, 144-166, 176-193, 239-261, 271-293, 305-324, 328-350, 363-385 and 395-417 568708016080 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 568708016082 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 568708016083 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 568708016084 inhibitor site; inhibition site 568708016085 active site 568708016086 dimer interface [polypeptide binding]; other site 568708016087 catalytic residue [active] 568708016089 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568708016090 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568708016091 Bacterial transcriptional regulator; Region: IclR; pfam01614 568708016094 glycogen phosphorylase; Provisional; Region: PRK14986 568708016095 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 568708016096 homodimer interface [polypeptide binding]; other site 568708016097 active site pocket [active] 568708016099 glycogen synthase; Provisional; Region: glgA; PRK00654 568708016100 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 568708016101 ADP-binding pocket [chemical binding]; other site 568708016102 homodimer interface [polypeptide binding]; other site 568708016105 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 568708016106 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 568708016107 ligand binding site; other site 568708016108 oligomer interface; other site 568708016109 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 568708016110 dimer interface [polypeptide binding]; other site 568708016111 N-terminal domain interface [polypeptide binding]; other site 568708016112 sulfate 1 binding site; other site 568708016114 glycogen debranching enzyme; Provisional; Region: PRK03705 568708016115 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 568708016116 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 568708016117 active site 568708016118 catalytic site [active] 568708016121 glycogen branching enzyme; Provisional; Region: PRK05402 568708016122 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 568708016123 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 568708016124 active site 568708016125 catalytic site [active] 568708016126 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 568708016130 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 568708016131 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 568708016134 low affinity gluconate transporter; Provisional; Region: PRK10472 568708016135 gluconate transporter; Region: gntP; TIGR00791 568708016136 13 probable transmembrane helices predicted for STM_MW35301 by TMHMM2.0 at aa 4-21, 28-47, 57-79, 104-126, 146-168, 175-197, 228-250, 262-284, 299-321, 328-350, 354-373, 386-408 and 423-445 568708016138 Signal peptide predicted for STM_MW35301 by SignalP 2.0 HMM (Signal peptide probability 0.669) with cleavage site probability 0.493 between residues 23 and 24 568708016139 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 568708016140 ATP-binding site [chemical binding]; other site 568708016141 Gluconate-6-phosphate binding site [chemical binding]; other site 568708016143 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 568708016144 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708016145 DNA binding site [nucleotide binding] 568708016146 domain linker motif; other site 568708016147 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 568708016148 putative ligand binding site [chemical binding]; other site 568708016149 putative dimerization interface [polypeptide binding]; other site 568708016152 Pirin-related protein [General function prediction only]; Region: COG1741 568708016153 Pirin; Region: Pirin; pfam02678 568708016155 putative oxidoreductase; Provisional; Region: PRK10206 568708016156 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568708016157 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568708016160 putative acetyltransferase YhhY; Provisional; Region: PRK10140 568708016161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708016162 Coenzyme A binding pocket [chemical binding]; other site 568708016164 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568708016165 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568708016166 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568708016167 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 568708016168 substrate binding site [chemical binding]; other site 568708016169 dimer interface [polypeptide binding]; other site 568708016170 ATP binding site [chemical binding]; other site 568708016173 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 568708016175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 568708016176 Protein of unknown function, DUF606; Region: DUF606; pfam04657 568708016177 Signal peptide predicted for STM_MW35381 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.734 between residues 27 and 28 568708016178 10 probable transmembrane helices predicted for STM_MW35381 by TMHMM2.0 at aa 7-26, 41-60, 80-97, 107-125, 138-157, 161-183, 196-218, 233-252, 257-276 and 286-308 568708016180 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 568708016181 active site 568708016182 substrate binding pocket [chemical binding]; other site 568708016183 homodimer interaction site [polypeptide binding]; other site 568708016185 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 568708016186 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 568708016188 Signal peptide predicted for STM_MW35401 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 24 and 25 568708016189 hypothetical protein; Provisional; Region: PRK10350 568708016190 Signal peptide predicted for STM_MW35411 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 17 and 18 568708016192 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 568708016193 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 568708016194 putative active site [active] 568708016195 catalytic site [active] 568708016196 putative metal binding site [ion binding]; other site 568708016198 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 568708016199 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 568708016200 Walker A/P-loop; other site 568708016201 ATP binding site [chemical binding]; other site 568708016202 Q-loop/lid; other site 568708016203 ABC transporter signature motif; other site 568708016204 Walker B; other site 568708016205 D-loop; other site 568708016206 H-loop/switch region; other site 568708016207 TOBE domain; Region: TOBE_2; pfam08402 568708016210 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568708016211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708016212 dimer interface [polypeptide binding]; other site 568708016213 conserved gate region; other site 568708016214 ABC-ATPase subunit interface; other site 568708016215 7 probable transmembrane helices predicted for STM_MW35441 by TMHMM2.0 at aa 7-29, 82-104, 111-130, 145-167, 188-210, 215-237 and 250-272 568708016217 Signal peptide predicted for STM_MW35441 by SignalP 2.0 HMM (Signal peptide probability 0.642) with cleavage site probability 0.418 between residues 34 and 35 568708016218 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 568708016219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708016220 dimer interface [polypeptide binding]; other site 568708016221 conserved gate region; other site 568708016222 putative PBP binding loops; other site 568708016223 ABC-ATPase subunit interface; other site 568708016224 6 probable transmembrane helices predicted for STM_MW35451 by TMHMM2.0 at aa 12-34, 71-93, 106-128, 157-179, 206-228 and 266-288 568708016226 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 568708016227 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568708016229 1 probable transmembrane helix predicted for STM_MW35461 by TMHMM2.0 at aa 7-29 568708016230 Signal peptide predicted for STM_MW35461 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 568708016231 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 568708016233 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 568708016235 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 568708016236 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568708016237 Walker A/P-loop; other site 568708016238 ATP binding site [chemical binding]; other site 568708016239 Q-loop/lid; other site 568708016240 ABC transporter signature motif; other site 568708016241 Walker B; other site 568708016242 D-loop; other site 568708016243 H-loop/switch region; other site 568708016245 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 568708016246 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568708016247 Walker A/P-loop; other site 568708016248 ATP binding site [chemical binding]; other site 568708016249 Q-loop/lid; other site 568708016250 ABC transporter signature motif; other site 568708016251 Walker B; other site 568708016252 D-loop; other site 568708016253 H-loop/switch region; other site 568708016255 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 568708016256 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 568708016257 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568708016258 TM-ABC transporter signature motif; other site 568708016259 10 probable transmembrane helices predicted for STM_MW35511 by TMHMM2.0 at aa 4-26, 47-66, 91-108, 120-142, 162-184, 193-210, 261-283, 315-337, 352-374 and 381-400 568708016261 Signal peptide predicted for STM_MW35511 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 20 and 21 568708016262 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568708016263 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568708016264 TM-ABC transporter signature motif; other site 568708016265 8 probable transmembrane helices predicted for STM_MW35521 by TMHMM2.0 at aa 15-37, 44-66, 70-92, 105-124, 153-175, 207-229, 244-266 and 282-301 568708016267 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568708016268 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 568708016269 dimerization interface [polypeptide binding]; other site 568708016270 ligand binding site [chemical binding]; other site 568708016272 Signal peptide predicted for STM_MW35531 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 568708016273 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 568708016275 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568708016276 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 568708016277 dimerization interface [polypeptide binding]; other site 568708016278 ligand binding site [chemical binding]; other site 568708016280 Signal peptide predicted for STM_MW35561 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 568708016281 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 568708016282 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568708016283 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568708016284 DNA binding residues [nucleotide binding] 568708016287 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 568708016288 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 568708016289 4 probable transmembrane helices predicted for STM_MW35581 by TMHMM2.0 at aa 71-93, 223-245, 266-288 and 323-342 568708016291 cell division protein FtsE; Provisional; Region: PRK10908 568708016292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708016293 Walker A/P-loop; other site 568708016294 ATP binding site [chemical binding]; other site 568708016295 Q-loop/lid; other site 568708016296 ABC transporter signature motif; other site 568708016297 Walker B; other site 568708016298 D-loop; other site 568708016299 H-loop/switch region; other site 568708016301 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 568708016302 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 568708016303 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 568708016304 P loop; other site 568708016305 GTP binding site [chemical binding]; other site 568708016308 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 568708016309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708016310 S-adenosylmethionine binding site [chemical binding]; other site 568708016312 hypothetical protein; Provisional; Region: PRK10910 568708016314 2 probable transmembrane helices predicted for STM_MW35621 by TMHMM2.0 at aa 4-23 and 30-52 568708016315 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 568708016317 1 probable transmembrane helix predicted for STM_MW35631 by TMHMM2.0 at aa 5-24 568708016318 Signal peptide predicted for STM_MW35631 by SignalP 2.0 HMM (Signal peptide probability 0.916) with cleavage site probability 0.574 between residues 18 and 19 568708016319 Predicted membrane protein [Function unknown]; Region: COG3714 568708016321 6 probable transmembrane helices predicted for STM_MW35641 by TMHMM2.0 at aa 28-45, 50-72, 77-96, 101-123, 130-152 and 156-178 568708016322 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 568708016323 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568708016324 metal-binding site [ion binding] 568708016325 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568708016326 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568708016328 5 probable transmembrane helices predicted for STM_MW35651 by TMHMM2.0 at aa 147-169, 189-211, 350-372, 387-409 and 690-712 568708016331 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 568708016332 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 568708016333 dimer interface [polypeptide binding]; other site 568708016334 ligand binding site [chemical binding]; other site 568708016335 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708016336 dimerization interface [polypeptide binding]; other site 568708016337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568708016338 dimer interface [polypeptide binding]; other site 568708016339 putative CheW interface [polypeptide binding]; other site 568708016340 Signal peptide predicted for STM_MW35661 by SignalP 2.0 HMM (Signal peptide probability 0.963) with cleavage site probability 0.427 between residues 31 and 32 568708016341 2 probable transmembrane helices predicted for STM_MW35661 by TMHMM2.0 at aa 10-32 and 195-217 568708016345 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 568708016346 CPxP motif; other site 568708016348 hypothetical protein; Provisional; Region: PRK11212 568708016349 6 probable transmembrane helices predicted for STM_MW35681 by TMHMM2.0 at aa 13-35, 45-64, 71-93, 108-130, 142-164 and 179-201 568708016351 hypothetical protein; Provisional; Region: PRK11615 568708016353 major facilitator superfamily transporter; Provisional; Region: PRK05122 568708016354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708016355 putative substrate translocation pore; other site 568708016356 12 probable transmembrane helices predicted for STM_MW35701 by TMHMM2.0 at aa 33-55, 65-87, 99-121, 136-158, 163-185, 189-211, 232-254, 264-283, 290-312, 322-344, 351-373 and 378-400 568708016358 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 568708016359 Domain of unknown function DUF20; Region: UPF0118; pfam01594 568708016360 8 probable transmembrane helices predicted for STM_MW35711 by TMHMM2.0 at aa 12-29, 33-55, 62-84, 141-163, 198-220, 224-246, 253-275 and 295-317 568708016362 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 568708016363 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 568708016365 nickel responsive regulator; Provisional; Region: PRK02967 568708016366 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 568708016369 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568708016370 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 568708016371 6 probable transmembrane helices predicted for STM_MW35741 by TMHMM2.0 at aa 25-47, 174-196, 230-252, 256-278, 285-302 and 344-366 568708016373 Signal peptide predicted for STM_MW35741 by SignalP 2.0 HMM (Signal peptide probability 0.882) with cleavage site probability 0.803 between residues 40 and 41 568708016374 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 568708016375 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568708016376 Walker A/P-loop; other site 568708016377 ATP binding site [chemical binding]; other site 568708016378 Q-loop/lid; other site 568708016379 ABC transporter signature motif; other site 568708016380 Walker B; other site 568708016381 D-loop; other site 568708016382 H-loop/switch region; other site 568708016383 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568708016384 Walker A/P-loop; other site 568708016385 ATP binding site [chemical binding]; other site 568708016386 Q-loop/lid; other site 568708016387 ABC transporter signature motif; other site 568708016388 Walker B; other site 568708016389 D-loop; other site 568708016390 H-loop/switch region; other site 568708016391 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568708016392 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 568708016393 5 probable transmembrane helices predicted for STM_MW35751 by TMHMM2.0 at aa 702-724, 752-774, 779-801, 808-830 and 869-891 568708016396 HlyD family secretion protein; Region: HlyD; pfam00529 568708016397 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568708016398 HlyD family secretion protein; Region: HlyD_3; pfam13437 568708016400 1 probable transmembrane helix predicted for STM_MW35761 by TMHMM2.0 at aa 7-26 568708016401 Signal peptide predicted for STM_MW35761 by SignalP 2.0 HMM (Signal peptide probability 0.921) with cleavage site probability 0.747 between residues 23 and 24 568708016402 Predicted flavoproteins [General function prediction only]; Region: COG2081 568708016403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568708016405 Signal peptide predicted for STM_MW35771 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.912 between residues 22 and 23 568708016406 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 568708016407 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 568708016408 Signal peptide predicted for STM_MW35781 by SignalP 2.0 HMM (Signal peptide probability 0.699) with cleavage site probability 0.429 between residues 32 and 33 568708016410 8 probable transmembrane helices predicted for STM_MW35781 by TMHMM2.0 at aa 13-35, 53-75, 82-104, 114-136, 166-183, 193-215, 339-361 and 431-453 568708016411 universal stress protein UspB; Provisional; Region: PRK04960 568708016413 2 probable transmembrane helices predicted for STM_MW35791 by TMHMM2.0 at aa 5-24 and 90-109 568708016414 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568708016415 Ligand Binding Site [chemical binding]; other site 568708016417 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 568708016418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708016419 putative substrate translocation pore; other site 568708016420 POT family; Region: PTR2; pfam00854 568708016421 14 probable transmembrane helices predicted for STM_MW35811 by TMHMM2.0 at aa 20-42, 52-74, 83-102, 107-124, 145-167, 171-193, 214-233, 237-255, 268-290, 314-336, 349-371, 386-408, 415-437 and 457-479 568708016423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708016424 S-adenosylmethionine binding site [chemical binding]; other site 568708016426 oligopeptidase A; Provisional; Region: PRK10911 568708016427 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 568708016428 active site 568708016429 Zn binding site [ion binding]; other site 568708016431 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 568708016432 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 568708016433 active site 568708016435 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 568708016437 glutathione reductase; Validated; Region: PRK06116 568708016438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568708016439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568708016440 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568708016444 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 568708016445 active site 568708016446 homodimer interface [polypeptide binding]; other site 568708016447 homotetramer interface [polypeptide binding]; other site 568708016449 1 probable transmembrane helix predicted for STM_MW35871 by TMHMM2.0 at aa 7-29 568708016450 Signal peptide predicted for STM_MW35871 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.988 between residues 20 and 21 568708016451 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 568708016452 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 568708016453 11 probable transmembrane helices predicted for STM_MW35881 by TMHMM2.0 at aa 20-42, 52-74, 87-109, 163-185, 227-249, 264-281, 294-316, 331-350, 357-374, 379-398 and 419-438 568708016455 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 568708016456 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568708016457 substrate binding site [chemical binding]; other site 568708016458 ATP binding site [chemical binding]; other site 568708016460 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 568708016461 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 568708016462 putative active site [active] 568708016463 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 568708016464 dimer interface [polypeptide binding]; other site 568708016465 active site 568708016467 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568708016468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708016469 DNA-binding site [nucleotide binding]; DNA binding site 568708016470 UTRA domain; Region: UTRA; pfam07702 568708016473 trehalase; Provisional; Region: treF; PRK13270 568708016474 Trehalase; Region: Trehalase; pfam01204 568708016476 1 probable transmembrane helix predicted for STM_MW35931 by TMHMM2.0 at aa 337-359 568708016477 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 568708016478 catalytic residue [active] 568708016479 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568708016480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708016481 DNA binding residues [nucleotide binding] 568708016482 dimerization interface [polypeptide binding]; other site 568708016484 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708016485 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708016486 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 568708016487 putative effector binding pocket; other site 568708016488 putative dimerization interface [polypeptide binding]; other site 568708016491 inner membrane protein YhjD; Region: TIGR00766 568708016493 6 probable transmembrane helices predicted for STM_MW35971 by TMHMM2.0 at aa 80-102, 135-157, 191-213, 233-255, 267-289 and 304-326 568708016494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708016495 metabolite-proton symporter; Region: 2A0106; TIGR00883 568708016496 putative substrate translocation pore; other site 568708016498 11 probable transmembrane helices predicted for STM_MW35981 by TMHMM2.0 at aa 32-54, 69-88, 109-131, 166-188, 195-217, 247-269, 290-312, 322-341, 348-370, 380-402 and 409-431 568708016500 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 568708016501 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 568708016503 1 probable transmembrane helix predicted for STM_MW35991 by TMHMM2.0 at aa 7-29 568708016504 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708016506 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568708016507 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568708016508 substrate binding site [chemical binding]; other site 568708016509 ATP binding site [chemical binding]; other site 568708016511 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 568708016512 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568708016515 Signal peptide predicted for STM_MW36021 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 24 and 25 568708016516 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 568708016517 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 568708016519 9 probable transmembrane helices predicted for STM_MW36031 by TMHMM2.0 at aa 5-27, 47-64, 77-99, 141-163, 184-206, 216-238, 289-311, 326-348 and 353-375 568708016520 putative diguanylate cyclase; Provisional; Region: PRK13561 568708016521 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568708016522 metal binding site [ion binding]; metal-binding site 568708016523 active site 568708016524 I-site; other site 568708016525 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708016528 1 probable transmembrane helix predicted for STM_MW36041 by TMHMM2.0 at aa 127-149 568708016529 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 568708016530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 568708016531 TPR motif; other site 568708016532 binding surface 568708016533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568708016534 TPR motif; other site 568708016535 binding surface 568708016536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568708016537 binding surface 568708016538 TPR motif; other site 568708016539 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 568708016541 Signal peptide predicted for STM_MW36051 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.523 between residues 46 and 47 568708016542 endo-1,4-D-glucanase; Provisional; Region: PRK11097 568708016544 1 probable transmembrane helix predicted for STM_MW36061 by TMHMM2.0 at aa 7-29 568708016545 Signal peptide predicted for STM_MW36061 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.850 between residues 22 and 23 568708016546 cellulose synthase regulator protein; Provisional; Region: PRK11114 568708016548 1 probable transmembrane helix predicted for STM_MW36071 by TMHMM2.0 at aa 603-625 568708016549 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 568708016550 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568708016551 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 568708016552 DXD motif; other site 568708016553 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568708016554 PilZ domain; Region: PilZ; pfam07238 568708016555 10 probable transmembrane helices predicted for STM_MW36081 by TMHMM2.0 at aa 28-50, 150-169, 173-190, 197-216, 229-251, 522-541, 545-567, 588-610, 633-655 and 668-690 568708016558 cell division protein; Provisional; Region: PRK10037 568708016560 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 568708016562 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 568708016563 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 568708016565 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 568708016567 1 probable transmembrane helix predicted for STM_MW36121 by TMHMM2.0 at aa 7-29 568708016568 pfam_scan;Pfam:PF11658; E()=2.2E-226;score=751.8;query 24-553;description=DUF3260 568708016570 pfam_scan;Pfam:PF01053; E()=6.9E-19;score=67.3;query7- 77;description=Cys_Met_Meta_PP 568708016572 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 568708016573 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 568708016574 11 probable transmembrane helices predicted for STM_MW36161 by TMHMM2.0 at aa 29-51, 56-73, 105-127, 147-169, 176-194, 214-236, 256-278, 303-325, 351-373, 377-399 and 412-431 568708016576 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 568708016577 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568708016578 Walker A/P-loop; other site 568708016579 ATP binding site [chemical binding]; other site 568708016580 Q-loop/lid; other site 568708016581 ABC transporter signature motif; other site 568708016582 Walker B; other site 568708016583 D-loop; other site 568708016584 H-loop/switch region; other site 568708016585 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568708016588 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 568708016589 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568708016590 Walker A/P-loop; other site 568708016591 ATP binding site [chemical binding]; other site 568708016592 Q-loop/lid; other site 568708016593 ABC transporter signature motif; other site 568708016594 Walker B; other site 568708016595 D-loop; other site 568708016596 H-loop/switch region; other site 568708016597 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568708016600 dipeptide transporter; Provisional; Region: PRK10913 568708016601 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568708016602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708016603 dimer interface [polypeptide binding]; other site 568708016604 conserved gate region; other site 568708016605 putative PBP binding loops; other site 568708016606 ABC-ATPase subunit interface; other site 568708016607 5 probable transmembrane helices predicted for STM_MW36191 by TMHMM2.0 at aa 31-53, 103-125, 140-162, 210-232 and 265-287 568708016609 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568708016610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708016611 dimer interface [polypeptide binding]; other site 568708016612 conserved gate region; other site 568708016613 putative PBP binding loops; other site 568708016614 ABC-ATPase subunit interface; other site 568708016615 6 probable transmembrane helices predicted for STM_MW36201 by TMHMM2.0 at aa 9-31, 99-121, 134-156, 202-221, 258-280 and 309-331 568708016617 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568708016618 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 568708016619 peptide binding site [polypeptide binding]; other site 568708016621 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 568708016622 13 probable transmembrane helices predicted for STM_MW36221 by TMHMM2.0 at aa 20-42, 47-69, 76-98, 103-125, 132-154, 169-191, 196-218, 233-255, 287-309, 319-341, 348-370, 380-402 and 409-431 568708016624 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 568708016626 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568708016627 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708016628 DNA binding site [nucleotide binding] 568708016629 domain linker motif; other site 568708016630 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 568708016631 putative dimerization interface [polypeptide binding]; other site 568708016632 putative ligand binding site [chemical binding]; other site 568708016634 1 probable transmembrane helix predicted for STM_MW36241 by TMHMM2.0 at aa 67-89 568708016636 phosphoethanolamine transferase; Provisional; Region: PRK11560 568708016637 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 568708016638 Sulfatase; Region: Sulfatase; pfam00884 568708016641 5 probable transmembrane helices predicted for STM_MW36251 by TMHMM2.0 at aa 12-31, 46-68, 81-103, 118-140 and 161-178 568708016642 Signal peptide predicted for STM_MW36251 by SignalP 2.0 HMM (Signal peptide probability 0.813) with cleavage site probability 0.796 between residues 37 and 38 568708016643 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 568708016645 Signal peptide predicted for STM_MW36261 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 568708016646 Signal peptide; signalp; query 1-25;cleavage_site_probability=0.992; 1.000 568708016647 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 568708016648 PapC N-terminal domain; Region: PapC_N; pfam13954 568708016649 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568708016650 PapC C-terminal domain; Region: PapC_C; pfam13953 568708016652 Signal peptide predicted for STM_MW36281 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 32 and 33 568708016653 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 568708016654 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708016655 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708016658 1 probable transmembrane helix predicted for STM_MW36291 by TMHMM2.0 at aa 7-29 568708016659 Signal peptide predicted for STM_MW36291 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 23 and 24 568708016660 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 568708016662 Signal peptide predicted for STM_MW36301 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25 568708016663 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 568708016665 1 probable transmembrane helix predicted for STM_MW36311 by TMHMM2.0 at aa 12-31 568708016666 Signal peptide predicted for STM_MW36311 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.667 between residues 30 and 31 568708016667 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 568708016669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708016670 Coenzyme A binding pocket [chemical binding]; other site 568708016672 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 568708016673 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 568708016674 molybdopterin cofactor binding site [chemical binding]; other site 568708016675 substrate binding site [chemical binding]; other site 568708016676 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 568708016677 molybdopterin cofactor binding site; other site 568708016680 putative outer membrane lipoprotein; Provisional; Region: PRK10510 568708016681 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568708016682 ligand binding site [chemical binding]; other site 568708016683 2 probable transmembrane helices predicted for STM_MW36351 by TMHMM2.0 at aa 25-44 and 51-73 568708016685 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 568708016686 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 568708016687 dimerization interface [polypeptide binding]; other site 568708016688 ligand binding site [chemical binding]; other site 568708016689 NADP binding site [chemical binding]; other site 568708016690 catalytic site [active] 568708016693 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 568708016695 1 probable transmembrane helix predicted for STM_MW36371 by TMHMM2.0 at aa 10-27 568708016696 Predicted transcriptional regulator [Transcription]; Region: COG2944 568708016697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708016698 salt bridge; other site 568708016699 non-specific DNA binding site [nucleotide binding]; other site 568708016700 sequence-specific DNA binding site [nucleotide binding]; other site 568708016702 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568708016703 DNA-binding site [nucleotide binding]; DNA binding site 568708016704 RNA-binding motif; other site 568708016706 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 568708016707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 568708016709 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568708016710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708016711 Coenzyme A binding pocket [chemical binding]; other site 568708016713 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 568708016714 DALR anticodon binding domain; Region: DALR_1; pfam05746 568708016717 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 568708016718 dimer interface [polypeptide binding]; other site 568708016719 motif 1; other site 568708016720 active site 568708016721 motif 2; other site 568708016722 motif 3; other site 568708016724 YsaB-like lipoprotein; Region: YsaB; pfam13983 568708016725 Signal peptide predicted for STM_MW36461 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.657 between residues 27 and 28 568708016726 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 568708016727 Acyltransferase family; Region: Acyl_transf_3; pfam01757 568708016729 10 probable transmembrane helices predicted for STM_MW36471 by TMHMM2.0 at aa 13-30, 45-67, 79-101, 114-136, 143-160, 175-194, 201-223, 233-255, 268-288 and 303-321 568708016730 xylulokinase; Provisional; Region: PRK15027 568708016731 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 568708016732 N- and C-terminal domain interface [polypeptide binding]; other site 568708016733 active site 568708016734 MgATP binding site [chemical binding]; other site 568708016735 catalytic site [active] 568708016736 metal binding site [ion binding]; metal-binding site 568708016737 xylulose binding site [chemical binding]; other site 568708016738 homodimer interface [polypeptide binding]; other site 568708016741 xylose isomerase; Provisional; Region: PRK05474 568708016742 xylose isomerase; Region: xylose_isom_A; TIGR02630 568708016744 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 568708016745 putative dimerization interface [polypeptide binding]; other site 568708016746 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568708016747 putative ligand binding site [chemical binding]; other site 568708016748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708016749 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568708016750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708016752 hypothetical protein; Provisional; Region: PRK10356 568708016753 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 568708016755 Signal peptide predicted for STM_MW36511 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.961 between residues 27 and 28 568708016756 alpha-amylase; Reviewed; Region: malS; PRK09505 568708016757 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 568708016758 active site 568708016759 catalytic site [active] 568708016760 Signal peptide predicted for STM_MW36521 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.643 between residues 17 and 18 568708016762 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 568708016763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568708016764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708016765 homodimer interface [polypeptide binding]; other site 568708016766 catalytic residue [active] 568708016768 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 568708016770 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568708016771 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568708016772 Bacterial transcriptional regulator; Region: IclR; pfam01614 568708016775 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 568708016777 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 568708016779 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 568708016780 4 probable transmembrane helices predicted for STM_MW36591 by TMHMM2.0 at aa 7-29, 44-66, 79-98 and 113-135 568708016782 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 568708016783 DctM-like transporters; Region: DctM; pfam06808 568708016784 Signal peptide predicted for STM_MW36601 by SignalP 2.0 HMM (Signal peptide probability 0.748) with cleavage site probability 0.369 between residues 33 and 34 568708016785 11 probable transmembrane helices predicted for STM_MW36601 by TMHMM2.0 at aa 4-26, 47-69, 93-124, 137-159, 169-191, 212-230, 234-256, 277-299, 314-347, 354-376 and 396-418 568708016787 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568708016788 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 568708016789 Signal peptide predicted for STM_MW36611 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 24 and 25 568708016791 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 568708016792 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 568708016793 putative N- and C-terminal domain interface [polypeptide binding]; other site 568708016794 putative active site [active] 568708016795 MgATP binding site [chemical binding]; other site 568708016796 catalytic site [active] 568708016797 metal binding site [ion binding]; metal-binding site 568708016798 putative xylulose binding site [chemical binding]; other site 568708016801 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 568708016802 active site 568708016803 dimer interface [polypeptide binding]; other site 568708016804 magnesium binding site [ion binding]; other site 568708016806 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 568708016807 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 568708016808 AP (apurinic/apyrimidinic) site pocket; other site 568708016809 DNA interaction; other site 568708016810 Metal-binding active site; metal-binding site 568708016812 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 568708016813 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 568708016814 intersubunit interface [polypeptide binding]; other site 568708016815 active site 568708016816 Zn2+ binding site [ion binding]; other site 568708016818 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 568708016819 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 568708016820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708016823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 568708016824 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 568708016826 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 568708016827 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568708016828 NAD(P) binding site [chemical binding]; other site 568708016829 catalytic residues [active] 568708016831 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568708016832 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568708016833 nucleotide binding site [chemical binding]; other site 568708016835 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 568708016836 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 568708016837 G1 box; other site 568708016838 putative GEF interaction site [polypeptide binding]; other site 568708016839 GTP/Mg2+ binding site [chemical binding]; other site 568708016840 Switch I region; other site 568708016841 G2 box; other site 568708016842 G3 box; other site 568708016843 Switch II region; other site 568708016844 G4 box; other site 568708016845 G5 box; other site 568708016846 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 568708016847 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 568708016848 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 568708016849 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 568708016854 selenocysteine synthase; Provisional; Region: PRK04311 568708016855 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 568708016856 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 568708016857 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568708016858 catalytic residue [active] 568708016860 putative glutathione S-transferase; Provisional; Region: PRK10357 568708016861 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 568708016862 putative C-terminal domain interface [polypeptide binding]; other site 568708016863 putative GSH binding site (G-site) [chemical binding]; other site 568708016864 putative dimer interface [polypeptide binding]; other site 568708016865 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 568708016866 dimer interface [polypeptide binding]; other site 568708016867 N-terminal domain interface [polypeptide binding]; other site 568708016868 putative substrate binding pocket (H-site) [chemical binding]; other site 568708016871 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 568708016872 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 568708016873 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 568708016874 active site 568708016875 P-loop; other site 568708016876 phosphorylation site [posttranslational modification] 568708016877 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568708016878 active site 568708016879 phosphorylation site [posttranslational modification] 568708016881 8 probable transmembrane helices predicted for STM_MW36731 by TMHMM2.0 at aa 20-42, 52-74, 87-109, 129-151, 212-234, 244-263, 270-292 and 312-334 568708016884 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 568708016885 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 568708016886 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 568708016889 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 568708016890 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 568708016892 hypothetical protein; Provisional; Region: PRK11020 568708016894 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 568708016895 Signal peptide predicted for STM_MW36781 by SignalP 2.0 HMM (Signal peptide probability 0.821) with cleavage site probability 0.749 between residues 21 and 22 568708016897 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 568708016898 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 568708016899 trimer interface [polypeptide binding]; other site 568708016900 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 568708016901 Haemagglutinin; Region: HIM; pfam05662 568708016902 Haemagglutinin; Region: HIM; pfam05662 568708016903 YadA-like C-terminal region; Region: YadA; pfam03895 568708016904 Signal peptide predicted for STM_MW36791 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.470 between residues 50 and 51 568708016908 L-lactate permease; Provisional; Region: PRK10420 568708016909 glycolate transporter; Provisional; Region: PRK09695 568708016910 12 probable transmembrane helices predicted for STM_MW36801 by TMHMM2.0 at aa 10-32, 39-58, 68-90, 119-141, 156-178, 199-218, 244-266, 299-321, 368-387, 407-424, 434-456 and 528-550 568708016912 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 568708016913 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708016914 DNA-binding site [nucleotide binding]; DNA binding site 568708016915 FCD domain; Region: FCD; pfam07729 568708016918 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 568708016919 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 568708016920 active site 568708016921 substrate binding site [chemical binding]; other site 568708016922 FMN binding site [chemical binding]; other site 568708016923 putative catalytic residues [active] 568708016925 putative rRNA methylase; Provisional; Region: PRK10358 568708016927 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568708016928 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708016929 DNA binding site [nucleotide binding] 568708016930 domain linker motif; other site 568708016931 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 568708016932 putative dimerization interface [polypeptide binding]; other site 568708016933 putative ligand binding site [chemical binding]; other site 568708016936 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 568708016937 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 568708016938 active site pocket [active] 568708016941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708016942 D-galactonate transporter; Region: 2A0114; TIGR00893 568708016943 putative substrate translocation pore; other site 568708016944 Signal peptide predicted for STM_MW36861 by SignalP 2.0 HMM (Signal peptide probability 0.800) with cleavage site probability 0.782 between residues 27 and 28 568708016945 12 probable transmembrane helices predicted for STM_MW36861 by TMHMM2.0 at aa 13-35, 50-72, 79-101, 105-127, 140-162, 172-189, 240-262, 277-299, 311-333, 338-360, 372-394 and 404-426 568708016947 serine acetyltransferase; Provisional; Region: cysE; PRK11132 568708016948 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 568708016949 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 568708016950 trimer interface [polypeptide binding]; other site 568708016951 active site 568708016952 substrate binding site [chemical binding]; other site 568708016953 CoA binding site [chemical binding]; other site 568708016955 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 568708016956 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 568708016957 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 568708016960 Signal peptide predicted for STM_MW36881 by SignalP 2.0 HMM (Signal peptide probability 0.796) with cleavage site probability 0.748 between residues 21 and 22 568708016961 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 568708016962 SecA binding site; other site 568708016963 Preprotein binding site; other site 568708016965 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 568708016966 GSH binding site [chemical binding]; other site 568708016967 catalytic residues [active] 568708016969 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568708016970 active site residue [active] 568708016972 1 probable transmembrane helix predicted for STM_MW36911 by TMHMM2.0 at aa 7-29 568708016973 phosphoglyceromutase; Provisional; Region: PRK05434 568708016974 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 568708016977 AmiB activator; Provisional; Region: PRK11637 568708016978 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 568708016979 Peptidase family M23; Region: Peptidase_M23; pfam01551 568708016980 Signal peptide predicted for STM_MW36931 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 42 and 43 568708016982 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 568708016983 NodB motif; other site 568708016984 putative active site [active] 568708016985 putative catalytic site [active] 568708016986 Zn binding site [ion binding]; other site 568708016987 Signal peptide predicted for STM_MW36941 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 23 and 24 568708016988 1 probable transmembrane helix predicted for STM_MW36941 by TMHMM2.0 at aa 7-29 568708016990 putative glycosyl transferase; Provisional; Region: PRK10073 568708016991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568708016992 active site 568708016995 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 568708016996 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 568708016997 NAD(P) binding site [chemical binding]; other site 568708017000 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 568708017001 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 568708017002 substrate-cofactor binding pocket; other site 568708017003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708017004 catalytic residue [active] 568708017006 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 568708017007 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 568708017008 NADP binding site [chemical binding]; other site 568708017009 homopentamer interface [polypeptide binding]; other site 568708017010 substrate binding site [chemical binding]; other site 568708017011 active site 568708017013 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 568708017014 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 568708017015 putative active site [active] 568708017017 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 568708017018 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 568708017019 putative active site [active] 568708017021 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 568708017022 O-antigen ligase RfaL; Provisional; Region: PRK15487 568708017023 10 probable transmembrane helices predicted for STM_MW37021 by TMHMM2.0 at aa 21-53, 68-85, 126-145, 160-182, 189-206, 210-225, 230-247, 325-347, 360-379 and 383-401 568708017025 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 568708017026 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568708017028 Signal peptide predicted for STM_MW37031 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.880 between residues 22 and 23 568708017029 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 568708017030 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 568708017032 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 568708017033 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 568708017034 Ligand binding site; other site 568708017035 metal-binding site 568708017036 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 568708017039 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 568708017040 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 568708017041 Ligand binding site; other site 568708017042 metal-binding site 568708017043 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 568708017046 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 568708017047 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 568708017048 putative ADP-binding pocket [chemical binding]; other site 568708017050 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 568708017051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568708017052 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 568708017054 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568708017055 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568708017057 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 568708017058 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 568708017059 putative active site [active] 568708017061 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 568708017062 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 568708017063 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568708017066 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 568708017067 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 568708017068 active site 568708017069 (T/H)XGH motif; other site 568708017071 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 568708017072 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 568708017073 DNA binding site [nucleotide binding] 568708017074 catalytic residue [active] 568708017075 H2TH interface [polypeptide binding]; other site 568708017076 putative catalytic residues [active] 568708017077 turnover-facilitating residue; other site 568708017078 intercalation triad [nucleotide binding]; other site 568708017079 8OG recognition residue [nucleotide binding]; other site 568708017080 putative reading head residues; other site 568708017081 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 568708017082 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568708017086 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 568708017088 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 568708017090 hypothetical protein; Reviewed; Region: PRK00024 568708017091 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 568708017092 MPN+ (JAMM) motif; other site 568708017093 Zinc-binding site [ion binding]; other site 568708017095 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 568708017096 Flavoprotein; Region: Flavoprotein; pfam02441 568708017097 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 568708017100 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 568708017101 trimer interface [polypeptide binding]; other site 568708017102 active site 568708017104 division inhibitor protein; Provisional; Region: slmA; PRK09480 568708017105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708017107 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568708017108 active site 568708017110 ribonuclease PH; Reviewed; Region: rph; PRK00173 568708017111 Ribonuclease PH; Region: RNase_PH_bact; cd11362 568708017112 hexamer interface [polypeptide binding]; other site 568708017113 active site 568708017116 hypothetical protein; Provisional; Region: PRK11820 568708017117 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 568708017118 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 568708017121 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708017122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708017123 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568708017124 dimerization interface [polypeptide binding]; other site 568708017127 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568708017128 Signal peptide predicted for STM_MW37261 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 568708017130 Predicted membrane protein [Function unknown]; Region: COG2860 568708017131 UPF0126 domain; Region: UPF0126; pfam03458 568708017132 UPF0126 domain; Region: UPF0126; pfam03458 568708017134 7 probable transmembrane helices predicted for STM_MW37271 by TMHMM2.0 at aa 5-22, 29-51, 64-81, 88-109, 114-136, 148-167 and 172-189 568708017135 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 568708017136 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 568708017137 nucleotide binding pocket [chemical binding]; other site 568708017138 K-X-D-G motif; other site 568708017139 catalytic site [active] 568708017140 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 568708017143 Signal peptide predicted for STM_MW37281 by SignalP 2.0 HMM (Signal peptide probability 0.761) with cleavage site probability 0.676 between residues 30 and 31 568708017144 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 568708017145 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 568708017146 catalytic site [active] 568708017147 G-X2-G-X-G-K; other site 568708017149 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 568708017151 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 568708017152 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568708017153 Zn2+ binding site [ion binding]; other site 568708017154 Mg2+ binding site [ion binding]; other site 568708017155 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 568708017156 synthetase active site [active] 568708017157 NTP binding site [chemical binding]; other site 568708017158 metal binding site [ion binding]; metal-binding site 568708017159 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 568708017160 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 568708017164 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 568708017165 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568708017166 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 568708017168 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 568708017169 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 568708017170 generic binding surface II; other site 568708017171 ssDNA binding site; other site 568708017172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568708017173 ATP binding site [chemical binding]; other site 568708017174 putative Mg++ binding site [ion binding]; other site 568708017175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708017176 nucleotide binding region [chemical binding]; other site 568708017177 ATP-binding site [chemical binding]; other site 568708017182 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 568708017184 9 probable transmembrane helices predicted for STM_MW37351 by TMHMM2.0 at aa 70-87, 94-116, 157-179, 213-235, 245-267, 274-292, 302-324, 336-358 and 368-390 568708017185 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 568708017187 11 probable transmembrane helices predicted for STM_MW37361 by TMHMM2.0 at aa 43-65, 90-112, 127-149, 156-178, 193-212, 219-241, 261-283, 346-368, 378-400, 407-429 and 439-458 568708017188 AsmA family; Region: AsmA; pfam05170 568708017189 Signal peptide predicted for STM_MW37371 by SignalP 2.0 HMM (Signal peptide probability 0.708) with cleavage site probability 0.479 between residues 31 and 32 568708017191 1 probable transmembrane helix predicted for STM_MW37371 by TMHMM2.0 at aa 7-26 568708017192 putative alpha-glucosidase; Provisional; Region: PRK10658 568708017193 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 568708017194 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 568708017195 active site 568708017196 homotrimer interface [polypeptide binding]; other site 568708017197 catalytic site [active] 568708017198 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 568708017200 putative transporter; Provisional; Region: PRK11462 568708017201 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 568708017202 11 probable transmembrane helices predicted for STM_MW37391 by TMHMM2.0 at aa 32-54, 81-100, 115-137, 150-170, 180-202, 232-254, 264-286, 293-315, 319-341, 362-384 and 399-421 568708017204 Virulence protein [General function prediction only]; Region: COG3943 568708017205 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 568708017206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568708017207 Transposase; Region: HTH_Tnp_1; pfam01527 568708017209 autotransport protein MisL; Provisional; Region: PRK15313 568708017210 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 568708017211 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568708017212 Signal peptide predicted for STM_MW37461 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 27 and 28 568708017213 1 probable transmembrane helix predicted for STM_MW37461 by TMHMM2.0 at aa 7-29 568708017216 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 568708017217 DNA binding site [nucleotide binding] 568708017219 1 probable transmembrane helix predicted for STM_MW37481 by TMHMM2.0 at aa 170-192 568708017220 Isochorismatase family; Region: Isochorismatase; pfam00857 568708017221 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 568708017222 catalytic triad [active] 568708017223 dimer interface [polypeptide binding]; other site 568708017224 conserved cis-peptide bond; other site 568708017226 2 probable transmembrane helices predicted for STM_MW37511 by TMHMM2.0 at aa 7-26 and 135-157 568708017227 Signal peptide predicted for STM_MW37511 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.977 between residues 26 and 27 568708017228 magnesium-transporting ATPase; Provisional; Region: PRK15122 568708017229 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 568708017230 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568708017231 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568708017232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708017233 motif II; other site 568708017234 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568708017235 8 probable transmembrane helices predicted for STM_MW37521 by TMHMM2.0 at aa 87-105, 115-134, 293-315, 325-347, 719-741, 779-801, 844-866 and 876-893 568708017240 magnesium transport protein MgtC; Provisional; Region: PRK15385 568708017241 MgtC family; Region: MgtC; pfam02308 568708017243 4 probable transmembrane helices predicted for STM_MW37531 by TMHMM2.0 at aa 5-27, 34-56, 66-83 and 90-112 568708017244 EamA-like transporter family; Region: EamA; pfam00892 568708017245 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 568708017246 EamA-like transporter family; Region: EamA; pfam00892 568708017247 Signal peptide predicted for STM_MW37541 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.960 between residues 25 and 26 568708017248 10 probable transmembrane helices predicted for STM_MW37541 by TMHMM2.0 at aa 7-29, 39-59, 72-94, 98-120, 127-144, 154-176, 183-205, 215-237, 250-272 and 276-293 568708017250 hypothetical protein; Provisional; Region: PRK09956 568708017251 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 568708017253 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 568708017255 pfam_scan;Pfam:PF03841; E()=1.3E-20;score=73.1;query14-280;description=SelA 568708017257 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 568708017258 5 probable transmembrane helices predicted for STM_MW37581 by TMHMM2.0 at aa 129-148, 152-174, 198-217, 237-259 and 266-285 568708017260 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 568708017262 5 probable transmembrane helices predicted for STM_MW37591 by TMHMM2.0 at aa 21-43, 93-110, 141-163, 178-200 and 207-239 568708017263 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 568708017264 active site 568708017265 phosphorylation site [posttranslational modification] 568708017267 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568708017268 active pocket/dimerization site; other site 568708017269 active site 568708017270 phosphorylation site [posttranslational modification] 568708017272 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 568708017273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708017274 Walker A motif; other site 568708017275 ATP binding site [chemical binding]; other site 568708017276 Walker B motif; other site 568708017277 arginine finger; other site 568708017278 Transcriptional antiterminator [Transcription]; Region: COG3933 568708017279 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 568708017280 active site 568708017281 active pocket/dimerization site; other site 568708017282 phosphorylation site [posttranslational modification] 568708017283 PRD domain; Region: PRD; pfam00874 568708017286 Signal peptide predicted for STM_MW37631 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 568708017287 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 568708017288 beta-galactosidase; Region: BGL; TIGR03356 568708017290 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 568708017291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708017292 putative substrate translocation pore; other site 568708017293 12 probable transmembrane helices predicted for STM_MW37651 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 110-132, 145-167, 177-196, 217-239, 254-276, 283-302, 307-329, 341-363 and 367-389 568708017295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 568708017297 Predicted transcriptional regulator [Transcription]; Region: COG2944 568708017298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708017299 non-specific DNA binding site [nucleotide binding]; other site 568708017300 salt bridge; other site 568708017301 sequence-specific DNA binding site [nucleotide binding]; other site 568708017303 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568708017304 dimerization domain swap beta strand [polypeptide binding]; other site 568708017305 regulatory protein interface [polypeptide binding]; other site 568708017306 active site 568708017307 regulatory phosphorylation site [posttranslational modification]; other site 568708017309 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568708017310 intersubunit interface [polypeptide binding]; other site 568708017311 active site 568708017312 zinc binding site [ion binding]; other site 568708017313 Na+ binding site [ion binding]; other site 568708017315 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 568708017316 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 568708017317 putative N- and C-terminal domain interface [polypeptide binding]; other site 568708017318 putative active site [active] 568708017319 putative MgATP binding site [chemical binding]; other site 568708017320 catalytic site [active] 568708017321 metal binding site [ion binding]; metal-binding site 568708017322 putative carbohydrate binding site [chemical binding]; other site 568708017325 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 568708017326 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568708017327 11 probable transmembrane helices predicted for STM_MW37711 by TMHMM2.0 at aa 13-35, 42-64, 98-120, 141-163, 178-200, 225-247, 251-270, 305-327, 337-356, 363-385 and 421-443 568708017329 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 568708017330 active site 568708017331 P-loop; other site 568708017332 phosphorylation site [posttranslational modification] 568708017334 Signal peptide predicted for STM_MW37721 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.954 between residues 20 and 21 568708017335 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568708017336 active site 568708017337 phosphorylation site [posttranslational modification] 568708017339 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568708017340 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708017341 DNA-binding site [nucleotide binding]; DNA binding site 568708017342 UTRA domain; Region: UTRA; pfam07702 568708017345 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 568708017347 1 probable transmembrane helix predicted for STM_MW37751 by TMHMM2.0 at aa 4-21 568708017348 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 568708017349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708017350 putative substrate translocation pore; other site 568708017351 12 probable transmembrane helices predicted for STM_MW37761 by TMHMM2.0 at aa 28-45, 67-89, 96-118, 123-145, 158-180, 190-212, 254-276, 296-318, 325-347, 357-379, 392-411 and 426-445 568708017353 regulatory protein UhpC; Provisional; Region: PRK11663 568708017354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708017355 putative substrate translocation pore; other site 568708017356 12 probable transmembrane helices predicted for STM_MW37771 by TMHMM2.0 at aa 26-45, 67-89, 96-118, 122-144, 156-178, 183-205, 245-267, 287-309, 322-344, 348-370, 377-399 and 409-431 568708017358 sensory histidine kinase UhpB; Provisional; Region: PRK11644 568708017359 MASE1; Region: MASE1; pfam05231 568708017360 Histidine kinase; Region: HisKA_3; pfam07730 568708017361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708017362 ATP binding site [chemical binding]; other site 568708017363 Mg2+ binding site [ion binding]; other site 568708017364 G-X-G motif; other site 568708017366 7 probable transmembrane helices predicted for STM_MW37781 by TMHMM2.0 at aa 7-29, 78-100, 112-130, 140-162, 186-205, 220-242 and 255-274 568708017369 Signal peptide predicted for STM_MW37781 by SignalP 2.0 HMM (Signal peptide probability 0.855) with cleavage site probability 0.579 between residues 32 and 33 568708017370 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 568708017371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708017372 active site 568708017373 phosphorylation site [posttranslational modification] 568708017374 intermolecular recognition site; other site 568708017375 dimerization interface [polypeptide binding]; other site 568708017376 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708017377 DNA binding residues [nucleotide binding] 568708017378 dimerization interface [polypeptide binding]; other site 568708017381 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 568708017382 active site 568708017383 catalytic residues [active] 568708017384 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 568708017385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708017386 putative substrate translocation pore; other site 568708017387 12 probable transmembrane helices predicted for STM_MW37811 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 109-128, 149-171, 205-227, 256-275, 290-312, 319-336, 340-362, 375-397 and 401-423 568708017389 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568708017390 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 568708017391 substrate binding site [chemical binding]; other site 568708017392 dimer interface [polypeptide binding]; other site 568708017393 ATP binding site [chemical binding]; other site 568708017395 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 568708017396 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 568708017397 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708017400 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 568708017401 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 568708017402 putative valine binding site [chemical binding]; other site 568708017403 dimer interface [polypeptide binding]; other site 568708017405 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 568708017406 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568708017407 PYR/PP interface [polypeptide binding]; other site 568708017408 dimer interface [polypeptide binding]; other site 568708017409 TPP binding site [chemical binding]; other site 568708017410 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568708017411 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 568708017412 TPP-binding site [chemical binding]; other site 568708017413 dimer interface [polypeptide binding]; other site 568708017418 Signal peptide predicted for STM_MW37852 by SignalP 2.0 HMM (Signal peptide probability 0.836) with cleavage site probability 0.795 between residues 18 and 19 568708017419 1 probable transmembrane helix predicted for STM_MW37871 by TMHMM2.0 at aa 6-28 568708017420 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 568708017421 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 568708017422 Signal peptide predicted for STM_MW37881 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.987 between residues 26 and 27 568708017423 10 probable transmembrane helices predicted for STM_MW37881 by TMHMM2.0 at aa 10-32, 39-61, 66-85, 98-117, 121-143, 150-167, 177-199, 216-235, 239-261 and 266-285 568708017425 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 568708017426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708017427 putative substrate translocation pore; other site 568708017429 11 probable transmembrane helices predicted for STM_MW37891 by TMHMM2.0 at aa 15-34, 41-60, 65-87, 100-122, 132-149, 170-192, 207-229, 242-264, 268-290, 297-319 and 329-351 568708017430 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 568708017432 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 568708017433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708017434 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 568708017435 dimerization interface [polypeptide binding]; other site 568708017436 substrate binding pocket [chemical binding]; other site 568708017439 permease DsdX; Provisional; Region: PRK09921 568708017440 gluconate transporter; Region: gntP; TIGR00791 568708017441 12 probable transmembrane helices predicted for STM_MW37921 by TMHMM2.0 at aa 4-23, 30-49, 54-76, 104-126, 146-168, 175-197, 226-248, 261-283, 303-322, 343-365, 385-407 and 420-442 568708017443 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 568708017444 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 568708017445 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568708017446 catalytic residue [active] 568708017448 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 568708017449 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 568708017450 Domain of unknown function (DUF202); Region: DUF202; pfam02656 568708017451 3 probable transmembrane helices predicted for STM_MW37951 by TMHMM2.0 at aa 21-43, 48-70 and 91-113 568708017452 Predicted membrane protein [Function unknown]; Region: COG2149 568708017453 3 probable transmembrane helices predicted for STM_MW37961 by TMHMM2.0 at aa 21-40, 50-72 and 92-114 568708017455 putative transporter; Validated; Region: PRK03818 568708017456 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 568708017457 TrkA-C domain; Region: TrkA_C; pfam02080 568708017458 TrkA-C domain; Region: TrkA_C; pfam02080 568708017459 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 568708017460 11 probable transmembrane helices predicted for STM_MW37971 by TMHMM2.0 at aa 4-21, 28-46, 61-83, 95-117, 160-182, 374-396, 400-419, 431-448, 463-485, 492-514 and 529-551 568708017463 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 568708017464 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 568708017465 putative dimer interface [polypeptide binding]; other site 568708017467 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 568708017468 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 568708017469 putative dimer interface [polypeptide binding]; other site 568708017471 hypothetical protein; Provisional; Region: PRK11616 568708017472 Signal peptide predicted for STM_MW38001 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.839 between residues 27 and 28 568708017474 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 568708017475 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 568708017476 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 568708017478 3 probable transmembrane helices predicted for STM_MW38021 by TMHMM2.0 at aa 2-24, 103-125 and 150-172 568708017479 Signal peptide predicted for STM_MW38021 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 22 and 23 568708017480 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 568708017481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708017482 Walker A/P-loop; other site 568708017483 ATP binding site [chemical binding]; other site 568708017484 Q-loop/lid; other site 568708017485 ABC transporter signature motif; other site 568708017486 Walker B; other site 568708017487 D-loop; other site 568708017488 H-loop/switch region; other site 568708017490 Haem-binding domain; Region: Haem_bd; pfam14376 568708017491 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 568708017493 1 probable transmembrane helix predicted for STM_MW38041 by TMHMM2.0 at aa 7-29 568708017494 chaperone protein TorD; Validated; Region: torD; PRK04976 568708017496 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 568708017497 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 568708017498 molybdopterin cofactor binding site [chemical binding]; other site 568708017499 substrate binding site [chemical binding]; other site 568708017500 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 568708017501 molybdopterin cofactor binding site; other site 568708017504 Signal peptide predicted for STM_MW38061 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 39 and 40 568708017505 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 568708017506 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 568708017508 1 probable transmembrane helix predicted for STM_MW38071 by TMHMM2.0 at aa 12-34 568708017509 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 568708017510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708017511 active site 568708017512 phosphorylation site [posttranslational modification] 568708017513 intermolecular recognition site; other site 568708017514 dimerization interface [polypeptide binding]; other site 568708017515 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708017516 DNA binding site [nucleotide binding] 568708017519 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 568708017520 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568708017522 Signal peptide predicted for STM_MW38091 by SignalP 2.0 HMM (Signal peptide probability 0.850) with cleavage site probability 0.727 between residues 22 and 23 568708017523 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 568708017524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708017525 dimer interface [polypeptide binding]; other site 568708017526 phosphorylation site [posttranslational modification] 568708017527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708017528 ATP binding site [chemical binding]; other site 568708017529 Mg2+ binding site [ion binding]; other site 568708017530 G-X-G motif; other site 568708017531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708017532 active site 568708017533 phosphorylation site [posttranslational modification] 568708017534 intermolecular recognition site; other site 568708017535 dimerization interface [polypeptide binding]; other site 568708017536 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 568708017537 putative binding surface; other site 568708017538 active site 568708017539 Signal peptide predicted for STM_MW38101 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.595 between residues 36 and 37 568708017540 2 probable transmembrane helices predicted for STM_MW38101 by TMHMM2.0 at aa 10-32 and 332-354 568708017545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708017546 D-galactonate transporter; Region: 2A0114; TIGR00893 568708017547 putative substrate translocation pore; other site 568708017548 12 probable transmembrane helices predicted for STM_MW38111 by TMHMM2.0 at aa 31-53, 68-90, 97-117, 122-144, 156-178, 182-203, 257-278, 293-315, 322-344, 354-376, 389-411 and 416-438 568708017550 galactonate dehydratase; Provisional; Region: PRK14017 568708017551 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 568708017552 putative active site pocket [active] 568708017553 putative metal binding site [ion binding]; other site 568708017556 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 568708017557 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 568708017558 active site 568708017559 intersubunit interface [polypeptide binding]; other site 568708017560 catalytic residue [active] 568708017562 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 568708017563 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 568708017565 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568708017566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708017567 DNA-binding site [nucleotide binding]; DNA binding site 568708017568 FCD domain; Region: FCD; pfam07729 568708017571 sugar phosphate phosphatase; Provisional; Region: PRK10513 568708017572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708017573 active site 568708017574 motif I; other site 568708017575 motif II; other site 568708017576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708017578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708017579 D-galactonate transporter; Region: 2A0114; TIGR00893 568708017580 putative substrate translocation pore; other site 568708017581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708017582 12 probable transmembrane helices predicted for STM_MW38171 by TMHMM2.0 at aa 13-35, 55-77, 89-111, 115-132, 145-167, 172-194, 239-261, 276-298, 305-324, 334-353, 366-388 and 393-415 568708017584 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 568708017585 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 568708017586 active site pocket [active] 568708017589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708017590 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708017591 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 568708017592 putative dimerization interface [polypeptide binding]; other site 568708017595 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 568708017596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708017597 Mg2+ binding site [ion binding]; other site 568708017598 G-X-G motif; other site 568708017599 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 568708017600 anchoring element; other site 568708017601 dimer interface [polypeptide binding]; other site 568708017602 ATP binding site [chemical binding]; other site 568708017603 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 568708017604 active site 568708017605 putative metal-binding site [ion binding]; other site 568708017606 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568708017611 recF protein; Region: recf; TIGR00611 568708017612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708017613 Walker A/P-loop; other site 568708017614 ATP binding site [chemical binding]; other site 568708017615 Q-loop/lid; other site 568708017616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708017617 ABC transporter signature motif; other site 568708017618 Walker B; other site 568708017619 D-loop; other site 568708017620 H-loop/switch region; other site 568708017622 DNA polymerase III subunit beta; Validated; Region: PRK05643 568708017623 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 568708017624 putative DNA binding surface [nucleotide binding]; other site 568708017625 dimer interface [polypeptide binding]; other site 568708017626 beta-clamp/clamp loader binding surface; other site 568708017627 beta-clamp/translesion DNA polymerase binding surface; other site 568708017631 DnaA N-terminal domain; Region: DnaA_N; pfam11638 568708017632 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 568708017633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708017634 Walker A motif; other site 568708017635 ATP binding site [chemical binding]; other site 568708017636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 568708017637 Walker B motif; other site 568708017638 arginine finger; other site 568708017639 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 568708017640 DnaA box-binding interface [nucleotide binding]; other site 568708017643 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 568708017645 ribonuclease P; Reviewed; Region: rnpA; PRK01732 568708017647 hypothetical protein; Validated; Region: PRK00041 568708017649 membrane protein insertase; Provisional; Region: PRK01318 568708017650 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 568708017651 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 568708017652 Signal peptide predicted for STM_MW38271 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.707 between residues 24 and 25 568708017653 4 probable transmembrane helices predicted for STM_MW38271 by TMHMM2.0 at aa 7-24, 346-368, 419-441 and 497-519 568708017655 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 568708017656 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 568708017657 trmE is a tRNA modification GTPase; Region: trmE; cd04164 568708017658 G1 box; other site 568708017659 GTP/Mg2+ binding site [chemical binding]; other site 568708017660 Switch I region; other site 568708017661 G2 box; other site 568708017662 Switch II region; other site 568708017663 G3 box; other site 568708017664 G4 box; other site 568708017665 G5 box; other site 568708017666 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 568708017670 pfam_scan;Pfam:PF00589; E()=1.0E-19;score=70.7;query219- 368;description=Phage_integrase 568708017672 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 568708017673 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 568708017674 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 568708017675 putative active site [active] 568708017676 putative NTP binding site [chemical binding]; other site 568708017677 putative nucleic acid binding site [nucleotide binding]; other site 568708017679 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 568708017680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708017681 putative substrate translocation pore; other site 568708017682 Signal peptide predicted for STM_MW38321 by SignalP 2.0 HMM (Signal peptide probability 0.661) with cleavage site probability 0.498 between residues 30 and 31 568708017683 12 probable transmembrane helices predicted for STM_MW38321 by TMHMM2.0 at aa 5-24, 39-58, 70-89, 99-116, 129-151, 156-178, 210-232, 242-264, 271-290, 294-316, 328-350 and 355-377 568708017685 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 568708017686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708017687 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 568708017688 substrate binding pocket [chemical binding]; other site 568708017689 dimerization interface [polypeptide binding]; other site 568708017692 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 568708017693 Predicted flavoprotein [General function prediction only]; Region: COG0431 568708017694 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568708017696 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 568708017697 13 probable transmembrane helices predicted for STM_MW38361 by TMHMM2.0 at aa 72-94, 104-126, 128-150, 155-177, 184-203, 218-240, 247-264, 295-317, 337-359, 369-391, 398-416, 431-453 and 466-484 568708017699 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 568708017700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708017701 active site 568708017702 motif I; other site 568708017703 motif II; other site 568708017705 transcriptional regulator PhoU; Provisional; Region: PRK11115 568708017706 PhoU domain; Region: PhoU; pfam01895 568708017707 PhoU domain; Region: PhoU; pfam01895 568708017709 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 568708017710 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 568708017711 Walker A/P-loop; other site 568708017712 ATP binding site [chemical binding]; other site 568708017713 Q-loop/lid; other site 568708017714 ABC transporter signature motif; other site 568708017715 Walker B; other site 568708017716 D-loop; other site 568708017717 H-loop/switch region; other site 568708017719 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 568708017720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708017721 dimer interface [polypeptide binding]; other site 568708017722 conserved gate region; other site 568708017723 putative PBP binding loops; other site 568708017724 ABC-ATPase subunit interface; other site 568708017725 6 probable transmembrane helices predicted for STM_MW38401 by TMHMM2.0 at aa 29-51, 88-110, 123-145, 150-169, 201-223 and 268-290 568708017727 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 568708017728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708017729 dimer interface [polypeptide binding]; other site 568708017730 conserved gate region; other site 568708017731 putative PBP binding loops; other site 568708017732 ABC-ATPase subunit interface; other site 568708017733 6 probable transmembrane helices predicted for STM_MW38411 by TMHMM2.0 at aa 21-43, 78-100, 112-134, 166-188, 227-249 and 282-304 568708017735 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568708017736 substrate binding pocket [chemical binding]; other site 568708017737 membrane-bound complex binding site; other site 568708017738 hinge residues; other site 568708017739 1 probable transmembrane helix predicted for STM_MW38421 by TMHMM2.0 at aa 7-29 568708017740 Signal peptide predicted for STM_MW38421 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.935 between residues 25 and 26 568708017741 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568708017742 active site 568708017743 P-loop; other site 568708017744 phosphorylation site [posttranslational modification] 568708017745 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 568708017746 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 568708017748 9 probable transmembrane helices predicted for STM_MW38431 by TMHMM2.0 at aa 134-156, 166-188, 201-223, 245-267, 279-301, 324-346, 359-381, 396-418 and 430-448 568708017750 Signal peptide predicted for STM_MW38431 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.486 between residues 24 and 25 568708017751 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 568708017752 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568708017753 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568708017754 shikimate binding site; other site 568708017755 NAD(P) binding site [chemical binding]; other site 568708017758 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 568708017759 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 568708017760 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 568708017762 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 568708017763 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 568708017764 glutaminase active site [active] 568708017765 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568708017766 dimer interface [polypeptide binding]; other site 568708017767 active site 568708017768 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 568708017769 dimer interface [polypeptide binding]; other site 568708017770 active site 568708017773 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 568708017774 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 568708017775 Substrate binding site; other site 568708017776 Mg++ binding site; other site 568708017777 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 568708017778 active site 568708017779 substrate binding site [chemical binding]; other site 568708017780 CoA binding site [chemical binding]; other site 568708017782 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 568708017783 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 568708017784 6 probable transmembrane helices predicted for STM_MW38481 by TMHMM2.0 at aa 25-47, 62-81, 94-116, 120-142, 158-192 and 207-229 568708017786 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 568708017787 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 568708017788 gamma subunit interface [polypeptide binding]; other site 568708017789 epsilon subunit interface [polypeptide binding]; other site 568708017790 LBP interface [polypeptide binding]; other site 568708017793 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 568708017794 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568708017795 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 568708017796 alpha subunit interaction interface [polypeptide binding]; other site 568708017797 Walker A motif; other site 568708017798 ATP binding site [chemical binding]; other site 568708017799 Walker B motif; other site 568708017800 inhibitor binding site; inhibition site 568708017801 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568708017805 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 568708017806 core domain interface [polypeptide binding]; other site 568708017807 delta subunit interface [polypeptide binding]; other site 568708017808 epsilon subunit interface [polypeptide binding]; other site 568708017810 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 568708017811 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568708017812 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 568708017813 beta subunit interaction interface [polypeptide binding]; other site 568708017814 Walker A motif; other site 568708017815 ATP binding site [chemical binding]; other site 568708017816 Walker B motif; other site 568708017817 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568708017821 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 568708017822 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 568708017824 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 568708017825 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 568708017827 1 probable transmembrane helix predicted for STM_MW38541 by TMHMM2.0 at aa 5-27 568708017828 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 568708017829 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 568708017830 5 probable transmembrane helices predicted for STM_MW38551 by TMHMM2.0 at aa 36-58, 100-122, 142-164, 211-233 and 243-265 568708017832 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 568708017833 4 probable transmembrane helices predicted for STM_MW38561 by TMHMM2.0 at aa 15-31, 36-58, 73-95 and 100-122 568708017835 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 568708017836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708017837 S-adenosylmethionine binding site [chemical binding]; other site 568708017839 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 568708017840 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 568708017841 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 568708017843 FMN-binding protein MioC; Provisional; Region: PRK09004 568708017845 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 568708017846 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568708017847 putative DNA binding site [nucleotide binding]; other site 568708017848 putative Zn2+ binding site [ion binding]; other site 568708017849 AsnC family; Region: AsnC_trans_reg; pfam01037 568708017852 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 568708017853 dimer interface [polypeptide binding]; other site 568708017854 active site 568708017856 hypothetical protein; Provisional; Region: yieM; PRK10997 568708017857 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 568708017858 metal ion-dependent adhesion site (MIDAS); other site 568708017860 regulatory ATPase RavA; Provisional; Region: PRK13531 568708017861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708017862 Walker A motif; other site 568708017863 ATP binding site [chemical binding]; other site 568708017864 Walker B motif; other site 568708017865 arginine finger; other site 568708017866 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 568708017868 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 568708017869 potassium uptake protein; Region: kup; TIGR00794 568708017870 Signal peptide predicted for STM_MW38641 by SignalP 2.0 HMM (Signal peptide probability 0.744) with cleavage site probability 0.744 between residues 22 and 23 568708017871 12 probable transmembrane helices predicted for STM_MW38641 by TMHMM2.0 at aa 7-29, 49-71, 102-124, 134-156, 168-190, 210-232, 245-267, 287-309, 335-357, 363-385, 392-414 and 419-441 568708017873 D-ribose pyranase; Provisional; Region: PRK11797 568708017875 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 568708017876 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568708017877 Walker A/P-loop; other site 568708017878 ATP binding site [chemical binding]; other site 568708017879 Q-loop/lid; other site 568708017880 ABC transporter signature motif; other site 568708017881 Walker B; other site 568708017882 D-loop; other site 568708017883 H-loop/switch region; other site 568708017884 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 568708017886 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568708017887 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568708017888 TM-ABC transporter signature motif; other site 568708017889 8 probable transmembrane helices predicted for STM_MW38671 by TMHMM2.0 at aa 21-43, 53-72, 74-93, 97-119, 126-145, 165-187, 221-243 and 275-297 568708017891 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 568708017892 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 568708017893 ligand binding site [chemical binding]; other site 568708017894 dimerization interface [polypeptide binding]; other site 568708017895 Signal peptide predicted for STM_MW38681 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.949 between residues 25 and 26 568708017897 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568708017898 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 568708017899 substrate binding site [chemical binding]; other site 568708017900 dimer interface [polypeptide binding]; other site 568708017901 ATP binding site [chemical binding]; other site 568708017903 transcriptional repressor RbsR; Provisional; Region: PRK10423 568708017904 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708017905 DNA binding site [nucleotide binding] 568708017906 domain linker motif; other site 568708017907 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 568708017908 dimerization interface [polypeptide binding]; other site 568708017909 ligand binding site [chemical binding]; other site 568708017912 putative transporter; Provisional; Region: PRK10504 568708017913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708017914 putative substrate translocation pore; other site 568708017915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708017917 14 probable transmembrane helices predicted for STM_MW38711 by TMHMM2.0 at aa 11-33, 48-70, 77-99, 103-125, 137-159, 164-181, 201-218, 222-244, 264-286, 291-313, 325-347, 351-373, 394-416 and 431-450 568708017918 Signal peptide predicted for STM_MW38711 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.952 between residues 27 and 28 568708017919 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568708017920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708017921 DNA-binding site [nucleotide binding]; DNA binding site 568708017922 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568708017925 transcriptional regulator HdfR; Provisional; Region: PRK03601 568708017926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708017927 LysR substrate binding domain; Region: LysR_substrate; pfam03466 568708017928 dimerization interface [polypeptide binding]; other site 568708017931 hypothetical protein; Provisional; Region: PRK11027 568708017933 putative ATP-dependent protease; Provisional; Region: PRK09862 568708017934 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 568708017935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708017936 Walker A motif; other site 568708017937 ATP binding site [chemical binding]; other site 568708017938 Walker B motif; other site 568708017939 arginine finger; other site 568708017940 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 568708017942 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 568708017943 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568708017944 PYR/PP interface [polypeptide binding]; other site 568708017945 dimer interface [polypeptide binding]; other site 568708017946 TPP binding site [chemical binding]; other site 568708017947 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568708017948 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 568708017949 TPP-binding site [chemical binding]; other site 568708017950 dimer interface [polypeptide binding]; other site 568708017954 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 568708017955 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 568708017956 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 568708017957 homodimer interface [polypeptide binding]; other site 568708017958 substrate-cofactor binding pocket; other site 568708017959 catalytic residue [active] 568708017961 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 568708017963 threonine dehydratase; Reviewed; Region: PRK09224 568708017964 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 568708017965 tetramer interface [polypeptide binding]; other site 568708017966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708017967 catalytic residue [active] 568708017968 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 568708017969 putative Ile/Val binding site [chemical binding]; other site 568708017970 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 568708017971 putative Ile/Val binding site [chemical binding]; other site 568708017974 Phage-related protein [Function unknown]; Region: COG4679 568708017976 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 568708017977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708017978 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 568708017979 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 568708017980 putative dimerization interface [polypeptide binding]; other site 568708017983 ketol-acid reductoisomerase; Validated; Region: PRK05225 568708017984 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 568708017985 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 568708017986 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 568708017989 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 568708017990 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 568708017994 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 568708017995 Part of AAA domain; Region: AAA_19; pfam13245 568708017996 Family description; Region: UvrD_C_2; pfam13538 568708017998 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 568708017999 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 568708018001 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 568708018002 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568708018003 ATP binding site [chemical binding]; other site 568708018004 Mg++ binding site [ion binding]; other site 568708018005 motif III; other site 568708018006 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708018007 nucleotide binding region [chemical binding]; other site 568708018008 ATP-binding site [chemical binding]; other site 568708018011 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568708018012 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 568708018013 catalytic residues [active] 568708018015 transcription termination factor Rho; Provisional; Region: rho; PRK09376 568708018016 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 568708018017 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 568708018018 RNA binding site [nucleotide binding]; other site 568708018019 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 568708018020 multimer interface [polypeptide binding]; other site 568708018021 Walker A motif; other site 568708018022 ATP binding site [chemical binding]; other site 568708018023 Walker B motif; other site 568708018027 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 568708018028 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 568708018029 Mg++ binding site [ion binding]; other site 568708018030 putative catalytic motif [active] 568708018031 substrate binding site [chemical binding]; other site 568708018032 11 probable transmembrane helices predicted for STM_MW38931 by TMHMM2.0 at aa 5-24, 45-65, 69-88, 105-127, 131-153, 160-179, 184-206, 213-232, 242-261, 294-311 and 321-338 568708018034 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 568708018035 Chain length determinant protein; Region: Wzz; pfam02706 568708018037 2 probable transmembrane helices predicted for STM_MW38941 by TMHMM2.0 at aa 29-51 and 323-342 568708018038 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 568708018039 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 568708018040 active site 568708018041 homodimer interface [polypeptide binding]; other site 568708018043 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 568708018044 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 568708018045 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 568708018046 Signal peptide predicted for STM_MW38961 by SignalP 2.0 HMM (Signal peptide probability 0.938) with cleavage site probability 0.852 between residues 23 and 24 568708018050 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 568708018051 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 568708018052 NAD binding site [chemical binding]; other site 568708018053 substrate binding site [chemical binding]; other site 568708018054 homodimer interface [polypeptide binding]; other site 568708018055 active site 568708018057 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 568708018058 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568708018060 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 568708018062 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 568708018063 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 568708018064 inhibitor-cofactor binding pocket; inhibition site 568708018065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708018066 catalytic residue [active] 568708018068 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568708018069 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 568708018071 12 probable transmembrane helices predicted for STM_MW39011 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 117-139, 146-165, 175-195, 216-238, 253-275, 296-318, 333-355, 362-384 and 390-412 568708018072 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 568708018074 putative common antigen polymerase; Provisional; Region: PRK02975 568708018076 11 probable transmembrane helices predicted for STM_MW39031 by TMHMM2.0 at aa 4-26, 33-55, 70-89, 116-138, 153-175, 182-201, 205-224, 226-245, 338-360, 381-398 and 408-430 568708018077 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 568708018078 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 568708018080 putative transport protein YifK; Provisional; Region: PRK10746 568708018082 12 probable transmembrane helices predicted for STM_MW39051 by TMHMM2.0 at aa 19-36, 40-59, 93-115, 125-147, 154-176, 191-213, 240-262, 277-299, 331-353, 358-380, 401-423 and 428-450 568708018083 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 568708018084 HemY protein N-terminus; Region: HemY_N; pfam07219 568708018087 1 probable transmembrane helix predicted for STM_MW39061 by TMHMM2.0 at aa 21-43 568708018088 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 568708018089 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 568708018091 1 probable transmembrane helix predicted for STM_MW39071 by TMHMM2.0 at aa 35-57 568708018092 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 568708018093 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 568708018094 active site 568708018096 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 568708018097 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 568708018098 domain interfaces; other site 568708018099 active site 568708018102 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 568708018103 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 568708018104 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 568708018106 3 probable transmembrane helices predicted for STM_MW39111 by TMHMM2.0 at aa 4-23, 25-47 and 81-103 568708018107 2 probable transmembrane helices predicted for STM_MW39121 by TMHMM2.0 at aa 28-45 and 49-71 568708018108 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 568708018109 putative iron binding site [ion binding]; other site 568708018111 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 568708018112 4 probable transmembrane helices predicted for STM_MW39151 by TMHMM2.0 at aa 20-42, 47-64, 71-93 and 103-125 568708018114 Signal peptide; signalp; query 1-22;cleavage_site_probability=0.937; 0.973 568708018115 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 568708018116 Signal peptide predicted for STM_MW39171 by SignalP 2.0 HMM (Signal peptide probability 0.906) with cleavage site probability 0.578 between residues 23 and 24 568708018117 1 probable transmembrane helix predicted for STM_MW39171 by TMHMM2.0 at aa 7-29 568708018118 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 568708018119 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 568708018120 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 568708018122 hypothetical protein; Provisional; Region: PRK10963 568708018124 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 568708018125 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 568708018126 active site 568708018127 Int/Topo IB signature motif; other site 568708018130 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 568708018131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708018132 motif II; other site 568708018134 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 568708018135 Part of AAA domain; Region: AAA_19; pfam13245 568708018136 Family description; Region: UvrD_C_2; pfam13538 568708018138 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 568708018139 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 568708018140 Cl binding site [ion binding]; other site 568708018141 oligomer interface [polypeptide binding]; other site 568708018143 2 probable transmembrane helices predicted for STM_MW39231 by TMHMM2.0 at aa 255-273 and 288-310 568708018144 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 568708018146 2 probable transmembrane helices predicted for STM_MW39241 by TMHMM2.0 at aa 50-72 and 76-107 568708018147 hypothetical protein; Provisional; Region: PRK11371 568708018148 4 probable transmembrane helices predicted for STM_MW39251 by TMHMM2.0 at aa 42-59, 63-85, 98-120 and 124-143 568708018149 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 568708018150 EamA-like transporter family; Region: EamA; cl17759 568708018151 10 probable transmembrane helices predicted for STM_MW39261 by TMHMM2.0 at aa 12-34, 38-60, 73-95, 100-122, 129-146, 150-167, 180-197, 212-234, 239-261 and 271-290 568708018153 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568708018154 CoenzymeA binding site [chemical binding]; other site 568708018155 subunit interaction site [polypeptide binding]; other site 568708018156 PHB binding site; other site 568708018158 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 568708018159 dimerization interface [polypeptide binding]; other site 568708018160 substrate binding site [chemical binding]; other site 568708018161 active site 568708018162 calcium binding site [ion binding]; other site 568708018164 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 568708018165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568708018166 ATP binding site [chemical binding]; other site 568708018167 putative Mg++ binding site [ion binding]; other site 568708018168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568708018169 nucleotide binding region [chemical binding]; other site 568708018170 ATP-binding site [chemical binding]; other site 568708018171 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 568708018172 Helicase and RNase D C-terminal; Region: HRDC; smart00341 568708018177 threonine efflux system; Provisional; Region: PRK10229 568708018178 6 probable transmembrane helices predicted for STM_MW39301 by TMHMM2.0 at aa 4-26, 42-64, 68-87, 119-141, 151-173 and 186-205 568708018180 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 568708018181 6 probable transmembrane helices predicted for STM_MW39311 by TMHMM2.0 at aa 5-27, 39-61, 71-88, 115-137, 147-169 and 188-205 568708018183 Signal peptide predicted for STM_MW39311 by SignalP 2.0 HMM (Signal peptide probability 0.874) with cleavage site probability 0.541 between residues 24 and 25 568708018184 lysophospholipase L2; Provisional; Region: PRK10749 568708018185 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568708018187 putative hydrolase; Provisional; Region: PRK10976 568708018188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708018189 active site 568708018190 motif I; other site 568708018191 motif II; other site 568708018192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708018194 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 568708018195 EamA-like transporter family; Region: EamA; pfam00892 568708018196 Signal peptide predicted for STM_MW39341 by SignalP 2.0 HMM (Signal peptide probability 0.655) with cleavage site probability 0.614 between residues 19 and 20 568708018197 10 probable transmembrane helices predicted for STM_MW39341 by TMHMM2.0 at aa 2-24, 28-47, 54-76, 80-102, 109-128, 138-157, 170-192, 202-224, 231-253 and 258-275 568708018199 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 568708018200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708018201 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 568708018202 putative dimerization interface [polypeptide binding]; other site 568708018205 Signal peptide predicted for STM_MW39351 by SignalP 2.0 HMM (Signal peptide probability 0.934) with cleavage site probability 0.662 between residues 34 and 35 568708018206 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 568708018207 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 568708018208 THF binding site; other site 568708018209 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 568708018210 substrate binding site [chemical binding]; other site 568708018211 THF binding site; other site 568708018212 zinc-binding site [ion binding]; other site 568708018215 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 568708018216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708018217 FeS/SAM binding site; other site 568708018218 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 568708018221 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 568708018223 uridine phosphorylase; Provisional; Region: PRK11178 568708018224 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 568708018226 DNA recombination protein RmuC; Provisional; Region: PRK10361 568708018227 RmuC family; Region: RmuC; pfam02646 568708018228 Signal peptide predicted for STM_MW39401 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.973 between residues 28 and 29 568708018229 1 probable transmembrane helix predicted for STM_MW39401 by TMHMM2.0 at aa 5-24 568708018231 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 568708018232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708018233 S-adenosylmethionine binding site [chemical binding]; other site 568708018234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 568708018236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 568708018237 SCP-2 sterol transfer family; Region: SCP2; pfam02036 568708018239 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 568708018240 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 568708018242 1 probable transmembrane helix predicted for STM_MW39431 by TMHMM2.0 at aa 523-542 568708018243 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 568708018244 1 probable transmembrane helix predicted for STM_MW39441 by TMHMM2.0 at aa 4-21 568708018246 sec-independent translocase; Provisional; Region: PRK01770 568708018247 sec-independent translocase; Provisional; Region: tatB; PRK00404 568708018248 1 probable transmembrane helix predicted for STM_MW39451 by TMHMM2.0 at aa 4-21 568708018249 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 568708018251 6 probable transmembrane helices predicted for STM_MW39461 by TMHMM2.0 at aa 20-42, 74-96, 116-138, 158-180, 193-210 and 215-237 568708018252 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 568708018253 active site 568708018255 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 568708018256 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 568708018257 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 568708018259 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 568708018261 FMN reductase; Validated; Region: fre; PRK08051 568708018262 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 568708018263 FAD binding pocket [chemical binding]; other site 568708018264 FAD binding motif [chemical binding]; other site 568708018265 phosphate binding motif [ion binding]; other site 568708018266 beta-alpha-beta structure motif; other site 568708018267 NAD binding pocket [chemical binding]; other site 568708018270 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 568708018271 Signal peptide predicted for STM_MW39511 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.644 between residues 26 and 27 568708018273 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 568708018274 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568708018275 dimer interface [polypeptide binding]; other site 568708018276 active site 568708018279 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 568708018280 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568708018281 substrate binding site [chemical binding]; other site 568708018282 oxyanion hole (OAH) forming residues; other site 568708018283 trimer interface [polypeptide binding]; other site 568708018284 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568708018285 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568708018286 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568708018290 proline dipeptidase; Provisional; Region: PRK13607 568708018291 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 568708018292 active site 568708018294 hypothetical protein; Provisional; Region: PRK11568 568708018295 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 568708018296 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 568708018299 potassium transporter; Provisional; Region: PRK10750 568708018300 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 568708018301 Signal peptide predicted for STM_MW39561 by SignalP 2.0 HMM (Signal peptide probability 0.648) with cleavage site probability 0.408 between residues 27 and 28 568708018302 10 probable transmembrane helices predicted for STM_MW39561 by TMHMM2.0 at aa 9-31, 35-57, 69-91, 133-155, 185-207, 238-260, 273-295, 332-354, 396-418 and 456-478 568708018304 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 568708018306 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 568708018307 Walker A motif; other site 568708018309 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 568708018310 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 568708018311 GTP binding site; other site 568708018312 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 568708018314 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 568708018315 serine/threonine protein kinase; Provisional; Region: PRK11768 568708018317 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 568708018318 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 568708018319 catalytic residues [active] 568708018320 hinge region; other site 568708018321 alpha helical domain; other site 568708018322 Signal peptide predicted for STM_MW39621 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.894 between residues 19 and 20 568708018324 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 568708018325 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 568708018326 putative acyl-acceptor binding pocket; other site 568708018328 3 probable transmembrane helices predicted for STM_MW39631 by TMHMM2.0 at aa 12-34, 49-66 and 122-140 568708018329 Signal peptide predicted for STM_MW39631 by SignalP 2.0 HMM (Signal peptide probability 0.652) with cleavage site probability 0.424 between residues 25 and 26 568708018330 DNA polymerase I; Provisional; Region: PRK05755 568708018331 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 568708018332 active site 568708018333 metal binding site 1 [ion binding]; metal-binding site 568708018334 putative 5' ssDNA interaction site; other site 568708018335 metal binding site 3; metal-binding site 568708018336 metal binding site 2 [ion binding]; metal-binding site 568708018337 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 568708018338 putative DNA binding site [nucleotide binding]; other site 568708018339 putative metal binding site [ion binding]; other site 568708018340 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 568708018341 active site 568708018342 catalytic site [active] 568708018343 substrate binding site [chemical binding]; other site 568708018344 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 568708018345 active site 568708018346 DNA binding site [nucleotide binding] 568708018347 catalytic site [active] 568708018352 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 568708018353 G1 box; other site 568708018354 GTP/Mg2+ binding site [chemical binding]; other site 568708018355 Switch I region; other site 568708018356 G2 box; other site 568708018357 G3 box; other site 568708018358 Switch II region; other site 568708018359 G4 box; other site 568708018360 G5 box; other site 568708018363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 568708018365 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 568708018366 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708018367 FeS/SAM binding site; other site 568708018368 HemN C-terminal domain; Region: HemN_C; pfam06969 568708018371 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 568708018372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708018373 active site 568708018374 phosphorylation site [posttranslational modification] 568708018375 intermolecular recognition site; other site 568708018376 dimerization interface [polypeptide binding]; other site 568708018377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708018378 Walker A motif; other site 568708018379 ATP binding site [chemical binding]; other site 568708018380 Walker B motif; other site 568708018381 arginine finger; other site 568708018382 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568708018386 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 568708018387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568708018388 putative active site [active] 568708018389 heme pocket [chemical binding]; other site 568708018390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708018391 dimer interface [polypeptide binding]; other site 568708018392 phosphorylation site [posttranslational modification] 568708018393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708018394 ATP binding site [chemical binding]; other site 568708018395 Mg2+ binding site [ion binding]; other site 568708018396 G-X-G motif; other site 568708018400 glutamine synthetase; Provisional; Region: glnA; PRK09469 568708018401 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 568708018402 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 568708018405 GTP-binding protein; Provisional; Region: PRK10218 568708018406 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 568708018407 G1 box; other site 568708018408 putative GEF interaction site [polypeptide binding]; other site 568708018409 GTP/Mg2+ binding site [chemical binding]; other site 568708018410 Switch I region; other site 568708018411 G2 box; other site 568708018412 G3 box; other site 568708018413 Switch II region; other site 568708018414 G4 box; other site 568708018415 G5 box; other site 568708018416 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 568708018417 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 568708018421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708018422 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568708018423 active site 568708018424 motif I; other site 568708018425 motif II; other site 568708018426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708018428 coproporphyrinogen III oxidase; Validated; Region: PRK08208 568708018429 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708018430 FeS/SAM binding site; other site 568708018431 HemN C-terminal domain; Region: HemN_C; pfam06969 568708018434 Sulfatase; Region: Sulfatase; cl17466 568708018436 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 568708018437 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 568708018438 Leucine-rich repeats; other site 568708018439 Substrate binding site [chemical binding]; other site 568708018440 outer membrane porin L; Provisional; Region: ompL; PRK09980 568708018442 Signal peptide predicted for STM_MW39801 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.908 between residues 20 and 21 568708018443 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 568708018444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708018445 putative substrate translocation pore; other site 568708018446 12 probable transmembrane helices predicted for STM_MW39811 by TMHMM2.0 at aa 20-42, 52-74, 86-108, 119-141, 154-176, 186-208, 237-259, 274-296, 303-325, 329-351, 380-402 and 415-437 568708018447 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 568708018448 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 568708018449 11 probable transmembrane helices predicted for STM_MW39821 by TMHMM2.0 at aa 46-68, 89-111, 121-143, 156-178, 188-210, 244-266, 276-295, 308-328, 333-355, 387-409 and 419-441 568708018450 alpha-glucosidase; Provisional; Region: PRK10426 568708018451 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 568708018452 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 568708018453 putative active site [active] 568708018454 putative catalytic site [active] 568708018456 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 568708018457 active site 568708018458 catalytic residues [active] 568708018460 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 568708018461 dimerization interface [polypeptide binding]; other site 568708018462 putative active cleft [active] 568708018464 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 568708018466 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 568708018467 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568708018469 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568708018470 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 568708018471 substrate binding site [chemical binding]; other site 568708018472 ATP binding site [chemical binding]; other site 568708018474 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568708018475 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568708018476 putative DNA binding site [nucleotide binding]; other site 568708018477 putative Zn2+ binding site [ion binding]; other site 568708018478 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708018481 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 568708018482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708018483 motif II; other site 568708018485 hypothetical protein; Reviewed; Region: PRK01637 568708018487 6 probable transmembrane helices predicted for STM_MW39911 by TMHMM2.0 at aa 39-61, 101-120, 140-162, 177-199, 212-234 and 244-266 568708018488 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 568708018489 putative active site [active] 568708018490 dimerization interface [polypeptide binding]; other site 568708018491 putative tRNAtyr binding site [nucleotide binding]; other site 568708018493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708018494 Coenzyme A binding pocket [chemical binding]; other site 568708018495 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 568708018498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708018499 non-specific DNA binding site [nucleotide binding]; other site 568708018500 salt bridge; other site 568708018501 sequence-specific DNA binding site [nucleotide binding]; other site 568708018503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 568708018505 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 568708018506 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 568708018508 Predicted transcriptional regulator [Transcription]; Region: COG2944 568708018509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708018510 non-specific DNA binding site [nucleotide binding]; other site 568708018511 salt bridge; other site 568708018512 sequence-specific DNA binding site [nucleotide binding]; other site 568708018514 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 568708018515 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 568708018517 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 568708018518 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 568708018520 4 probable transmembrane helices predicted for STM_MW39991 by TMHMM2.0 at aa 21-40, 55-77, 114-136 and 151-173 568708018521 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 568708018522 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 568708018525 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 568708018526 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 568708018527 [4Fe-4S] binding site [ion binding]; other site 568708018528 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568708018529 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 568708018530 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 568708018531 molybdopterin cofactor binding site; other site 568708018535 Signal peptide predicted for STM_MW40011 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 33 and 34 568708018536 1 probable transmembrane helix predicted for STM_MW40011 by TMHMM2.0 at aa 11-33 568708018537 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 568708018539 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 568708018540 Signal peptide predicted for STM_MW40031 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.997 between residues 21 and 22 568708018541 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 568708018542 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 568708018543 4 probable transmembrane helices predicted for STM_MW40051 by TMHMM2.0 at aa 4-26, 38-60, 65-82 and 87-106 568708018545 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 568708018546 5 probable transmembrane helices predicted for STM_MW40061 by TMHMM2.0 at aa 21-43, 58-80, 127-149, 159-178 and 191-213 568708018548 Signal peptide predicted for STM_MW40061 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.979 between residues 36 and 37 568708018549 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568708018550 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708018551 non-specific DNA binding site [nucleotide binding]; other site 568708018552 salt bridge; other site 568708018553 sequence-specific DNA binding site [nucleotide binding]; other site 568708018554 Cupin domain; Region: Cupin_2; cl17218 568708018557 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 568708018559 lactaldehyde reductase; Region: lactal_redase; TIGR02638 568708018560 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 568708018561 dimer interface [polypeptide binding]; other site 568708018562 active site 568708018563 metal binding site [ion binding]; metal-binding site 568708018565 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 568708018566 intersubunit interface [polypeptide binding]; other site 568708018567 active site 568708018568 Zn2+ binding site [ion binding]; other site 568708018570 L-rhamnose isomerase; Provisional; Region: PRK01076 568708018571 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 568708018573 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 568708018574 N- and C-terminal domain interface [polypeptide binding]; other site 568708018575 active site 568708018576 putative catalytic site [active] 568708018577 metal binding site [ion binding]; metal-binding site 568708018578 ATP binding site [chemical binding]; other site 568708018579 rhamnulokinase; Provisional; Region: rhaB; PRK10640 568708018580 carbohydrate binding site [chemical binding]; other site 568708018583 transcriptional activator RhaS; Provisional; Region: PRK13503 568708018584 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 568708018585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708018586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708018589 transcriptional activator RhaR; Provisional; Region: PRK13502 568708018590 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 568708018591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708018594 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 568708018595 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 568708018597 10 probable transmembrane helices predicted for STM_MW40151 by TMHMM2.0 at aa 4-26, 38-55, 70-92, 99-121, 136-155, 175-192, 212-234, 254-276, 291-309 and 321-343 568708018598 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 568708018599 Signal peptide predicted for STM_MW40161 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.975 between residues 22 and 23 568708018601 DctM-like transporters; Region: DctM; pfam06808 568708018602 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568708018603 12 probable transmembrane helices predicted for STM_MW40171 by TMHMM2.0 at aa 10-41, 61-83, 103-125, 146-168, 178-200, 221-243, 248-267, 280-302, 312-334, 341-360, 370-392 and 404-426 568708018605 Signal peptide predicted for STM_MW40171 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.885 between residues 22 and 23 568708018606 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 568708018607 4 probable transmembrane helices predicted for STM_MW40181 by TMHMM2.0 at aa 10-32, 48-66, 86-108 and 129-151 568708018609 Signal peptide predicted for STM_MW40181 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.932 between residues 27 and 28 568708018610 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568708018611 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 568708018613 Signal peptide predicted for STM_MW40191 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 24 and 25 568708018614 superoxide dismutase; Provisional; Region: PRK10925 568708018615 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 568708018616 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 568708018619 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 568708018620 MOSC domain; Region: MOSC; pfam03473 568708018621 3-alpha domain; Region: 3-alpha; pfam03475 568708018624 SnoaL-like domain; Region: SnoaL_2; pfam12680 568708018625 two-component sensor protein; Provisional; Region: cpxA; PRK09470 568708018626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708018627 dimerization interface [polypeptide binding]; other site 568708018628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708018629 dimer interface [polypeptide binding]; other site 568708018630 phosphorylation site [posttranslational modification] 568708018631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708018632 ATP binding site [chemical binding]; other site 568708018633 Mg2+ binding site [ion binding]; other site 568708018634 G-X-G motif; other site 568708018637 2 probable transmembrane helices predicted for STM_MW40231 by TMHMM2.0 at aa 5-27 and 165-187 568708018639 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 568708018640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708018641 active site 568708018642 intermolecular recognition site; other site 568708018643 dimerization interface [polypeptide binding]; other site 568708018644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708018645 DNA binding site [nucleotide binding] 568708018648 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 568708018649 dimer interface [polypeptide binding]; other site 568708018650 Signal peptide predicted for STM_MW40251 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 568708018651 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 568708018652 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568708018653 Signal peptide predicted for STM_MW40261 by SignalP 2.0 HMM (Signal peptide probability 0.913) with cleavage site probability 0.343 between residues 30 and 31 568708018654 6 probable transmembrane helices predicted for STM_MW40261 by TMHMM2.0 at aa 12-34, 38-60, 80-102, 117-139, 158-175 and 180-199 568708018656 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 568708018657 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 568708018658 active site 568708018659 ADP/pyrophosphate binding site [chemical binding]; other site 568708018660 dimerization interface [polypeptide binding]; other site 568708018661 allosteric effector site; other site 568708018662 fructose-1,6-bisphosphate binding site; other site 568708018664 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568708018665 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568708018666 substrate binding pocket [chemical binding]; other site 568708018667 membrane-bound complex binding site; other site 568708018668 Signal peptide predicted for STM_MW40281 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 19 and 20 568708018670 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 568708018671 Signal peptide predicted for STM_MW40291 by SignalP 2.0 HMM (Signal peptide probability 0.923) with cleavage site probability 0.355 between residues 18 and 19 568708018673 1 probable transmembrane helix predicted for STM_MW40291 by TMHMM2.0 at aa 5-23 568708018674 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 568708018675 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 568708018676 12 probable transmembrane helices predicted for STM_MW40301 by TMHMM2.0 at aa 12-34, 44-66, 79-96, 106-128, 149-171, 176-198, 228-247, 262-284, 291-310, 320-342, 362-384 and 399-421 568708018678 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568708018679 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 568708018680 putative substrate binding site [chemical binding]; other site 568708018681 putative ATP binding site [chemical binding]; other site 568708018683 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 568708018684 Signal peptide predicted for STM_MW40321 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.788 between residues 22 and 23 568708018686 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568708018687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708018688 DNA-binding site [nucleotide binding]; DNA binding site 568708018689 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 568708018690 UTRA domain; Region: UTRA; pfam07702 568708018695 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 568708018697 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 568708018698 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 568708018699 putative N- and C-terminal domain interface [polypeptide binding]; other site 568708018700 putative active site [active] 568708018701 putative MgATP binding site [chemical binding]; other site 568708018702 catalytic site [active] 568708018703 metal binding site [ion binding]; metal-binding site 568708018704 putative carbohydrate binding site [chemical binding]; other site 568708018705 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 568708018708 transcriptional regulator LsrR; Provisional; Region: PRK15418 568708018709 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 568708018710 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 568708018712 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 568708018713 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568708018714 Walker A/P-loop; other site 568708018715 ATP binding site [chemical binding]; other site 568708018716 Q-loop/lid; other site 568708018717 ABC transporter signature motif; other site 568708018718 Walker B; other site 568708018719 D-loop; other site 568708018720 H-loop/switch region; other site 568708018721 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 568708018723 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568708018724 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568708018725 TM-ABC transporter signature motif; other site 568708018726 Signal peptide predicted for STM_MW40401 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.607 between residues 29 and 30 568708018727 9 probable transmembrane helices predicted for STM_MW40401 by TMHMM2.0 at aa 13-32, 36-58, 65-87, 91-113, 118-135, 155-177, 210-232, 250-272 and 279-301 568708018729 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568708018730 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568708018731 TM-ABC transporter signature motif; other site 568708018732 9 probable transmembrane helices predicted for STM_MW40411 by TMHMM2.0 at aa 7-29, 39-61, 66-88, 92-114, 119-141, 161-183, 214-236, 251-282 and 295-314 568708018734 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 568708018735 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 568708018736 ligand binding site [chemical binding]; other site 568708018737 Signal peptide predicted for STM_MW40421 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 26 and 27 568708018738 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 568708018739 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 568708018740 putative active site; other site 568708018741 catalytic residue [active] 568708018743 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 568708018745 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 568708018746 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 568708018747 substrate binding site [chemical binding]; other site 568708018748 hexamer interface [polypeptide binding]; other site 568708018749 metal binding site [ion binding]; metal-binding site 568708018750 1 probable transmembrane helix predicted for STM_MW40451 by TMHMM2.0 at aa 12-34 568708018752 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 568708018753 triosephosphate isomerase; Provisional; Region: PRK14567 568708018754 substrate binding site [chemical binding]; other site 568708018755 dimer interface [polypeptide binding]; other site 568708018756 catalytic triad [active] 568708018758 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 568708018760 Signal peptide predicted for STM_MW40471 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 23 and 24 568708018761 Predicted membrane protein [Function unknown]; Region: COG3152 568708018763 4 probable transmembrane helices predicted for STM_MW40481 by TMHMM2.0 at aa 20-37, 41-63, 75-97 and 101-123 568708018764 ferredoxin-NADP reductase; Provisional; Region: PRK10926 568708018765 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 568708018766 FAD binding pocket [chemical binding]; other site 568708018767 FAD binding motif [chemical binding]; other site 568708018768 phosphate binding motif [ion binding]; other site 568708018769 beta-alpha-beta structure motif; other site 568708018770 NAD binding pocket [chemical binding]; other site 568708018773 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 568708018774 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 568708018775 putative active site [active] 568708018777 glycerol kinase; Provisional; Region: glpK; PRK00047 568708018778 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 568708018779 N- and C-terminal domain interface [polypeptide binding]; other site 568708018780 active site 568708018781 MgATP binding site [chemical binding]; other site 568708018782 catalytic site [active] 568708018783 metal binding site [ion binding]; metal-binding site 568708018784 glycerol binding site [chemical binding]; other site 568708018785 homotetramer interface [polypeptide binding]; other site 568708018786 homodimer interface [polypeptide binding]; other site 568708018787 FBP binding site [chemical binding]; other site 568708018788 protein IIAGlc interface [polypeptide binding]; other site 568708018791 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 568708018792 amphipathic channel; other site 568708018793 Asn-Pro-Ala signature motifs; other site 568708018795 6 probable transmembrane helices predicted for STM_MW40521 by TMHMM2.0 at aa 12-34, 44-66, 86-108, 145-167, 180-202 and 232-251 568708018796 septal ring assembly protein ZapB; Provisional; Region: PRK15422 568708018798 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 568708018800 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 568708018801 UbiA prenyltransferase family; Region: UbiA; pfam01040 568708018802 9 probable transmembrane helices predicted for STM_MW40551 by TMHMM2.0 at aa 21-40, 45-64, 99-121, 125-144, 151-173, 178-200, 230-249, 253-270 and 291-308 568708018804 Signal peptide predicted for STM_MW40551 by SignalP 2.0 HMM (Signal peptide probability 0.900) with cleavage site probability 0.900 between residues 36 and 37 568708018805 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 568708018806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708018807 Walker A motif; other site 568708018808 ATP binding site [chemical binding]; other site 568708018809 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 568708018810 Walker B motif; other site 568708018811 arginine finger; other site 568708018812 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568708018815 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 568708018816 active site 568708018817 HslU subunit interaction site [polypeptide binding]; other site 568708018819 essential cell division protein FtsN; Provisional; Region: PRK10927 568708018820 cell division protein FtsN; Provisional; Region: PRK12757 568708018822 1 probable transmembrane helix predicted for STM_MW40581 by TMHMM2.0 at aa 35-57 568708018823 Signal peptide predicted for STM_MW40581 by SignalP 2.0 HMM (Signal peptide probability 0.697) with cleavage site probability 0.325 between residues 45 and 46 568708018824 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708018825 DNA binding site [nucleotide binding] 568708018826 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 568708018827 domain linker motif; other site 568708018828 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 568708018829 dimerization interface [polypeptide binding]; other site 568708018830 ligand binding site [chemical binding]; other site 568708018833 primosome assembly protein PriA; Validated; Region: PRK05580 568708018834 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568708018835 ATP binding site [chemical binding]; other site 568708018836 putative Mg++ binding site [ion binding]; other site 568708018837 helicase superfamily c-terminal domain; Region: HELICc; smart00490 568708018838 ATP-binding site [chemical binding]; other site 568708018841 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 568708018843 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 568708018845 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 568708018847 1 probable transmembrane helix predicted for STM_MW40631 by TMHMM2.0 at aa 7-26 568708018848 Signal peptide predicted for STM_MW40631 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 22 and 23 568708018849 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 568708018850 dimerization interface [polypeptide binding]; other site 568708018851 DNA binding site [nucleotide binding] 568708018852 corepressor binding sites; other site 568708018854 cystathionine gamma-synthase; Provisional; Region: PRK08045 568708018855 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568708018856 homodimer interface [polypeptide binding]; other site 568708018857 substrate-cofactor binding pocket; other site 568708018858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708018859 catalytic residue [active] 568708018861 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 568708018862 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 568708018863 putative catalytic residues [active] 568708018864 putative nucleotide binding site [chemical binding]; other site 568708018865 putative aspartate binding site [chemical binding]; other site 568708018866 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 568708018867 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 568708018868 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 568708018872 mechanosensitive channel MscS; Provisional; Region: PRK10334 568708018873 Conserved TM helix; Region: TM_helix; pfam05552 568708018874 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568708018877 3 probable transmembrane helices predicted for STM_MW40671 by TMHMM2.0 at aa 25-44, 64-86 and 96-118 568708018878 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 568708018879 9 probable transmembrane helices predicted for STM_MW40681 by TMHMM2.0 at aa 21-40, 60-82, 89-111, 121-143, 148-170, 175-194, 215-237, 252-274 and 295-314 568708018880 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 568708018881 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 568708018882 active site 568708018883 metal binding site [ion binding]; metal-binding site 568708018884 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 568708018887 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 568708018888 FAD binding site [chemical binding]; other site 568708018890 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 568708018891 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 568708018892 heme binding site [chemical binding]; other site 568708018893 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 568708018895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 568708018897 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 568708018898 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 568708018899 dimer interface [polypeptide binding]; other site 568708018900 active site 568708018901 metal binding site [ion binding]; metal-binding site 568708018903 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 568708018904 active site 568708018905 intersubunit interactions; other site 568708018906 catalytic residue [active] 568708018908 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568708018909 dimerization domain swap beta strand [polypeptide binding]; other site 568708018910 regulatory protein interface [polypeptide binding]; other site 568708018911 active site 568708018912 regulatory phosphorylation site [posttranslational modification]; other site 568708018913 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 568708018914 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 568708018915 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568708018916 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568708018917 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568708018918 active site 568708018919 phosphorylation site [posttranslational modification] 568708018925 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 568708018926 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 568708018927 8 probable transmembrane helices predicted for STM_MW40771 by TMHMM2.0 at aa 21-40, 60-82, 95-117, 132-154, 175-194, 214-236, 283-305 and 315-334 568708018928 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568708018929 active site 568708018930 P-loop; other site 568708018931 phosphorylation site [posttranslational modification] 568708018932 Signal peptide predicted for STM_MW40781 by SignalP 2.0 HMM (Signal peptide probability 0.962) with cleavage site probability 0.795 between residues 20 and 21 568708018934 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 568708018935 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 568708018936 dimer interface [polypeptide binding]; other site 568708018937 active site 568708018938 glycine loop; other site 568708018941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708018942 FeS/SAM binding site; other site 568708018943 pyruvate formate lyase II activase; Provisional; Region: PRK10076 568708018945 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568708018946 active site 568708018947 P-loop; other site 568708018948 phosphorylation site [posttranslational modification] 568708018949 Signal peptide predicted for STM_MW40811 by SignalP 2.0 HMM (Signal peptide probability 0.801) with cleavage site probability 0.752 between residues 24 and 25 568708018951 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568708018952 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708018954 hypothetical protein; Provisional; Region: PRK10649 568708018955 Sulfatase; Region: Sulfatase; pfam00884 568708018957 5 probable transmembrane helices predicted for STM_MW40831 by TMHMM2.0 at aa 13-35, 50-67, 69-91, 118-140 and 153-170 568708018958 Signal peptide predicted for STM_MW40831 by SignalP 2.0 HMM (Signal peptide probability 0.695) with cleavage site probability 0.641 between residues 33 and 34 568708018959 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 568708018960 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 568708018962 acetylornithine deacetylase; Provisional; Region: PRK05111 568708018963 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 568708018964 metal binding site [ion binding]; metal-binding site 568708018965 putative dimer interface [polypeptide binding]; other site 568708018968 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 568708018969 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 568708018972 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 568708018973 nucleotide binding site [chemical binding]; other site 568708018974 N-acetyl-L-glutamate binding site [chemical binding]; other site 568708018976 argininosuccinate lyase; Provisional; Region: PRK04833 568708018977 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 568708018978 active sites [active] 568708018979 tetramer interface [polypeptide binding]; other site 568708018981 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 568708018982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708018983 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 568708018984 dimerization interface [polypeptide binding]; other site 568708018987 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 568708018988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568708018989 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568708018993 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 568708018994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708018996 hypothetical protein; Provisional; Region: PRK11056 568708018997 Signal peptide predicted for STM_MW40921 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.938 between residues 26 and 27 568708018999 3 probable transmembrane helices predicted for STM_MW40921 by TMHMM2.0 at aa 25-47, 60-82 and 86-108 568708019000 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 568708019001 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 568708019002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708019003 S-adenosylmethionine binding site [chemical binding]; other site 568708019005 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 568708019006 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568708019007 N-terminal plug; other site 568708019008 ligand-binding site [chemical binding]; other site 568708019009 Signal peptide predicted for STM_MW40941 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 568708019012 glutamate racemase; Provisional; Region: PRK00865 568708019014 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 568708019015 FAD binding domain; Region: FAD_binding_4; pfam01565 568708019016 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 568708019019 Biotin operon repressor [Transcription]; Region: BirA; COG1654 568708019020 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 568708019021 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 568708019022 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 568708019026 pantothenate kinase; Provisional; Region: PRK05439 568708019027 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 568708019028 ATP-binding site [chemical binding]; other site 568708019029 CoA-binding site [chemical binding]; other site 568708019030 Mg2+-binding site [ion binding]; other site 568708019032 elongation factor Tu; Reviewed; Region: PRK00049 568708019033 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 568708019034 G1 box; other site 568708019035 GEF interaction site [polypeptide binding]; other site 568708019036 GTP/Mg2+ binding site [chemical binding]; other site 568708019037 Switch I region; other site 568708019038 G2 box; other site 568708019039 G3 box; other site 568708019040 Switch II region; other site 568708019041 G4 box; other site 568708019042 G5 box; other site 568708019043 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 568708019044 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 568708019045 Antibiotic Binding Site [chemical binding]; other site 568708019049 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 568708019050 3 probable transmembrane helices predicted for STM_MW41001 by TMHMM2.0 at aa 34-51, 55-77 and 109-131 568708019052 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 568708019053 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 568708019054 putative homodimer interface [polypeptide binding]; other site 568708019055 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 568708019056 heterodimer interface [polypeptide binding]; other site 568708019057 homodimer interface [polypeptide binding]; other site 568708019060 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 568708019061 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 568708019062 23S rRNA interface [nucleotide binding]; other site 568708019063 L7/L12 interface [polypeptide binding]; other site 568708019064 putative thiostrepton binding site; other site 568708019065 L25 interface [polypeptide binding]; other site 568708019068 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 568708019069 mRNA/rRNA interface [nucleotide binding]; other site 568708019071 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 568708019072 23S rRNA interface [nucleotide binding]; other site 568708019073 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 568708019075 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 568708019076 core dimer interface [polypeptide binding]; other site 568708019077 peripheral dimer interface [polypeptide binding]; other site 568708019078 L10 interface [polypeptide binding]; other site 568708019079 L11 interface [polypeptide binding]; other site 568708019080 putative EF-Tu interaction site [polypeptide binding]; other site 568708019081 putative EF-G interaction site [polypeptide binding]; other site 568708019083 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 568708019084 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 568708019085 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 568708019086 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 568708019087 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 568708019088 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 568708019089 RPB3 interaction site [polypeptide binding]; other site 568708019090 RPB1 interaction site [polypeptide binding]; other site 568708019091 RPB11 interaction site [polypeptide binding]; other site 568708019092 RPB10 interaction site [polypeptide binding]; other site 568708019099 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 568708019100 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 568708019101 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 568708019102 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 568708019103 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 568708019104 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 568708019105 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 568708019106 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 568708019107 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 568708019108 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 568708019109 DNA binding site [nucleotide binding] 568708019110 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 568708019116 3 probable transmembrane helices predicted for STM_MW41081 by TMHMM2.0 at aa 20-42, 52-74 and 86-105 568708019117 type III secretion system protein; Provisional; Region: PRK15384 568708019118 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 568708019119 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 568708019120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708019121 FeS/SAM binding site; other site 568708019122 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 568708019124 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 568708019125 ThiS interaction site; other site 568708019126 putative active site [active] 568708019127 tetramer interface [polypeptide binding]; other site 568708019129 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 568708019130 thiS-thiF/thiG interaction site; other site 568708019132 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 568708019133 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 568708019134 ATP binding site [chemical binding]; other site 568708019135 substrate interface [chemical binding]; other site 568708019138 1 probable transmembrane helix predicted for STM_MW41151 by TMHMM2.0 at aa 26-48 568708019139 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 568708019140 thiamine phosphate binding site [chemical binding]; other site 568708019141 active site 568708019142 pyrophosphate binding site [ion binding]; other site 568708019144 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 568708019145 ThiC-associated domain; Region: ThiC-associated; pfam13667 568708019146 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 568708019148 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 568708019150 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 568708019151 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 568708019152 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 568708019153 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 568708019154 putative NADH binding site [chemical binding]; other site 568708019155 putative active site [active] 568708019156 nudix motif; other site 568708019157 putative metal binding site [ion binding]; other site 568708019161 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 568708019162 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 568708019163 substrate binding site [chemical binding]; other site 568708019164 active site 568708019166 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 568708019167 Active_site [active] 568708019169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 568708019171 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568708019172 IHF dimer interface [polypeptide binding]; other site 568708019173 IHF - DNA interface [nucleotide binding]; other site 568708019175 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 568708019177 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 568708019178 dimer interface [polypeptide binding]; other site 568708019179 1 probable transmembrane helix predicted for STM_MW41251 by TMHMM2.0 at aa 7-29 568708019180 Signal peptide predicted for STM_MW41251 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.971 between residues 26 and 27 568708019181 sensor protein ZraS; Provisional; Region: PRK10364 568708019182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708019183 dimer interface [polypeptide binding]; other site 568708019184 phosphorylation site [posttranslational modification] 568708019185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708019186 ATP binding site [chemical binding]; other site 568708019187 Mg2+ binding site [ion binding]; other site 568708019188 G-X-G motif; other site 568708019189 2 probable transmembrane helices predicted for STM_MW41261 by TMHMM2.0 at aa 13-35 and 204-223 568708019192 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 568708019193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708019194 active site 568708019195 phosphorylation site [posttranslational modification] 568708019196 intermolecular recognition site; other site 568708019197 dimerization interface [polypeptide binding]; other site 568708019198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708019199 Walker A motif; other site 568708019200 ATP binding site [chemical binding]; other site 568708019201 Walker B motif; other site 568708019202 arginine finger; other site 568708019203 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568708019207 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 568708019208 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 568708019209 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 568708019210 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 568708019214 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 568708019215 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 568708019216 purine monophosphate binding site [chemical binding]; other site 568708019217 dimer interface [polypeptide binding]; other site 568708019218 putative catalytic residues [active] 568708019219 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 568708019222 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568708019223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708019224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568708019225 Coenzyme A binding pocket [chemical binding]; other site 568708019227 homoserine O-succinyltransferase; Provisional; Region: PRK05368 568708019228 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 568708019229 proposed active site lysine [active] 568708019230 conserved cys residue [active] 568708019232 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 568708019233 malate synthase A; Region: malate_syn_A; TIGR01344 568708019234 active site 568708019236 isocitrate lyase; Provisional; Region: PRK15063 568708019237 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 568708019238 tetramer interface [polypeptide binding]; other site 568708019239 active site 568708019240 Mg2+/Mn2+ binding site [ion binding]; other site 568708019242 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 568708019243 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 568708019245 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 568708019247 transcriptional repressor IclR; Provisional; Region: PRK11569 568708019248 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568708019249 Bacterial transcriptional regulator; Region: IclR; pfam01614 568708019252 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 568708019253 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 568708019254 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 568708019255 substrate binding pocket [chemical binding]; other site 568708019256 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 568708019257 B12 binding site [chemical binding]; other site 568708019258 cobalt ligand [ion binding]; other site 568708019259 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 568708019265 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 568708019266 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 568708019267 Signal peptide predicted for STM_MW41381 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.919 between residues 38 and 39 568708019269 7 probable transmembrane helices predicted for STM_MW41381 by TMHMM2.0 at aa 42-64, 74-96, 108-130, 150-172, 177-199, 214-236 and 249-271 568708019270 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 568708019271 active site pocket [active] 568708019272 oxyanion hole [active] 568708019273 catalytic triad [active] 568708019274 active site nucleophile [active] 568708019276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 568708019278 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 568708019279 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568708019280 RNA binding surface [nucleotide binding]; other site 568708019281 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 568708019282 probable active site [active] 568708019285 hypothetical protein; Provisional; Region: PRK10515 568708019287 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 568708019288 Sodium Bile acid symporter family; Region: SBF; pfam01758 568708019289 9 probable transmembrane helices predicted for STM_MW41441 by TMHMM2.0 at aa 7-24, 29-51, 64-86, 92-114, 119-141, 156-178, 191-213, 217-239 and 260-282 568708019291 ATPase domain 568708019292 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 568708019293 1 probable transmembrane helix predicted for STM_MW41461 by TMHMM2.0 at aa 15-37 568708019294 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 568708019295 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 568708019296 BTP6 568708019297 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 568708019298 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 568708019299 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 568708019301 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 568708019303 Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948 568708019305 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 568708019307 9 probable transmembrane helices predicted for STM_MW41531 by TMHMM2.0 at aa 7-29, 73-92, 99-118, 128-150, 206-228, 256-275, 288-310, 315-334 and 341-363 568708019308 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 568708019309 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 568708019310 Ligand binding site; other site 568708019311 Putative Catalytic site; other site 568708019312 DXD motif; other site 568708019314 2 probable transmembrane helices predicted for STM_MW41541 by TMHMM2.0 at aa 227-249 and 264-286 568708019315 Predicted membrane protein [Function unknown]; Region: COG2246 568708019316 4 probable transmembrane helices predicted for STM_MW41551 by TMHMM2.0 at aa 9-31, 35-54, 67-84 and 94-116 568708019318 Signal peptide predicted for STM_MW41551 by SignalP 2.0 HMM (Signal peptide probability 0.762) with cleavage site probability 0.712 between residues 37 and 38 568708019319 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 568708019320 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 568708019322 Phage protein D [General function prediction only]; Region: COG3500 568708019324 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 568708019326 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 568708019328 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 568708019329 Phage tail tube protein FII [General function prediction only]; Region: COG3498 568708019331 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 568708019333 Gp37 protein; Region: Gp37; pfam09646 568708019335 Signal peptide predicted for STM_MW41651 by SignalP 2.0 HMM (Signal peptide probability 0.655) with cleavage site probability 0.343 between residues 30 and 31 568708019336 1 probable transmembrane helix predicted for STM_MW41651 by TMHMM2.0 at aa 10-29 568708019337 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 568708019338 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568708019339 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568708019340 catalytic residue [active] 568708019342 Signal peptide predicted for STM_MW41661 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.993 between residues 19 and 20 568708019343 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 568708019344 3 probable transmembrane helices predicted for STM_MW41671 by TMHMM2.0 at aa 5-24, 29-51 and 71-93 568708019345 Signal peptide predicted for STM_MW41671 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.941 between residues 29 and 30 568708019346 Mor transcription activator family; Region: Mor; pfam08765 568708019348 aspartate kinase III; Validated; Region: PRK09084 568708019349 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 568708019350 nucleotide binding site [chemical binding]; other site 568708019351 substrate binding site [chemical binding]; other site 568708019352 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 568708019353 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 568708019354 dimer interface [polypeptide binding]; other site 568708019357 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 568708019358 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 568708019359 active site 568708019360 dimer interface [polypeptide binding]; other site 568708019361 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 568708019362 dimer interface [polypeptide binding]; other site 568708019363 active site 568708019365 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 568708019366 Signal peptide predicted for STM_MW41711 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 22 and 23 568708019368 1 probable transmembrane helix predicted for STM_MW41711 by TMHMM2.0 at aa 5-27 568708019369 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 568708019370 Signal peptide predicted for STM_MW41721 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.351 between residues 30 and 31 568708019372 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 568708019373 Signal peptide predicted for STM_MW41731 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.977 between residues 20 and 21 568708019374 1 probable transmembrane helix predicted for STM_MW41731 by TMHMM2.0 at aa 5-27 568708019376 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 568708019377 Signal peptide predicted for STM_MW41741 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 568708019379 Predicted membrane protein [Function unknown]; Region: COG3223 568708019380 4 probable transmembrane helices predicted for STM_MW41751 by TMHMM2.0 at aa 13-35, 55-77, 84-103 and 113-130 568708019382 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568708019383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708019384 dimer interface [polypeptide binding]; other site 568708019385 conserved gate region; other site 568708019386 putative PBP binding loops; other site 568708019387 ABC-ATPase subunit interface; other site 568708019388 6 probable transmembrane helices predicted for STM_MW41761 by TMHMM2.0 at aa 13-35, 89-111, 124-143, 153-175, 205-227 and 258-280 568708019390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568708019391 dimer interface [polypeptide binding]; other site 568708019392 conserved gate region; other site 568708019393 putative PBP binding loops; other site 568708019394 ABC-ATPase subunit interface; other site 568708019395 8 probable transmembrane helices predicted for STM_MW41771 by TMHMM2.0 at aa 17-36, 40-57, 70-92, 284-306, 319-341, 370-392, 413-435 and 484-506 568708019397 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 568708019398 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 568708019399 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 568708019401 Signal peptide predicted for STM_MW41781 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 29 and 30 568708019402 1 probable transmembrane helix predicted for STM_MW41781 by TMHMM2.0 at aa 7-29 568708019403 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 568708019404 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 568708019405 Walker A/P-loop; other site 568708019406 ATP binding site [chemical binding]; other site 568708019407 Q-loop/lid; other site 568708019408 ABC transporter signature motif; other site 568708019409 Walker B; other site 568708019410 D-loop; other site 568708019411 H-loop/switch region; other site 568708019412 TOBE domain; Region: TOBE_2; pfam08402 568708019415 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 568708019416 trimer interface; other site 568708019417 sugar binding site [chemical binding]; other site 568708019418 Signal peptide predicted for STM_MW41811 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.972 between residues 25 and 26 568708019420 maltose regulon periplasmic protein; Provisional; Region: PRK10564 568708019421 Signal peptide predicted for STM_MW41821 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 26 and 27 568708019422 1 probable transmembrane helix predicted for STM_MW41821 by TMHMM2.0 at aa 7-26 568708019424 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 568708019426 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 568708019427 UbiA prenyltransferase family; Region: UbiA; pfam01040 568708019428 7 probable transmembrane helices predicted for STM_MW41841 by TMHMM2.0 at aa 23-40, 45-67, 99-132, 160-182, 203-225, 229-251 and 272-289 568708019430 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 568708019431 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 568708019432 putative acyl-acceptor binding pocket; other site 568708019434 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 568708019436 2 probable transmembrane helices predicted for STM_MW41861 by TMHMM2.0 at aa 57-79 and 99-121 568708019437 LexA repressor; Validated; Region: PRK00215 568708019438 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 568708019439 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568708019440 Catalytic site [active] 568708019443 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 568708019444 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 568708019445 12 probable transmembrane helices predicted for STM_MW41881 by TMHMM2.0 at aa 11-33, 43-65, 89-111, 131-153, 160-182, 187-209, 241-263, 267-289, 321-343, 353-375, 388-405 and 409-428 568708019447 hypothetical protein; Provisional; Region: PRK10428 568708019449 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568708019450 metal binding site 2 [ion binding]; metal-binding site 568708019451 putative DNA binding helix; other site 568708019452 metal binding site 1 [ion binding]; metal-binding site 568708019453 dimer interface [polypeptide binding]; other site 568708019454 structural Zn2+ binding site [ion binding]; other site 568708019456 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 568708019457 Signal peptide predicted for STM_MW41921 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 24 and 25 568708019458 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 568708019459 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 568708019460 FMN binding site [chemical binding]; other site 568708019461 active site 568708019462 catalytic residues [active] 568708019463 substrate binding site [chemical binding]; other site 568708019465 phage shock protein G; Reviewed; Region: pspG; PRK09459 568708019466 Signal peptide predicted for STM_MW41941 by SignalP 2.0 HMM (Signal peptide probability 0.967) with cleavage site probability 0.416 between residues 31 and 32 568708019468 2 probable transmembrane helices predicted for STM_MW41941 by TMHMM2.0 at aa 7-29 and 39-61 568708019469 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 568708019470 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 568708019471 NADP binding site [chemical binding]; other site 568708019472 dimer interface [polypeptide binding]; other site 568708019475 replicative DNA helicase; Provisional; Region: PRK08006 568708019476 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 568708019477 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 568708019478 Walker A motif; other site 568708019479 ATP binding site [chemical binding]; other site 568708019480 Walker B motif; other site 568708019481 DNA binding loops [nucleotide binding] 568708019484 alanine racemase; Reviewed; Region: alr; PRK00053 568708019485 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 568708019486 active site 568708019487 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568708019488 substrate binding site [chemical binding]; other site 568708019489 catalytic residues [active] 568708019490 dimer interface [polypeptide binding]; other site 568708019493 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 568708019494 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568708019495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708019496 homodimer interface [polypeptide binding]; other site 568708019497 catalytic residue [active] 568708019499 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 568708019500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708019501 active site 568708019502 motif I; other site 568708019503 motif II; other site 568708019504 Signal peptide predicted for STM_MW41991 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.961 between residues 23 and 24 568708019506 Uncharacterized conserved protein [Function unknown]; Region: COG0432 568708019508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 568708019510 1 probable transmembrane helix predicted for STM_MW42031 by TMHMM2.0 at aa 7-29 568708019511 Signal peptide predicted for STM_MW42031 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.519 between residues 21 and 22 568708019512 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 568708019513 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568708019514 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568708019515 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 568708019517 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 568708019518 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568708019519 dimer interface [polypeptide binding]; other site 568708019520 ssDNA binding site [nucleotide binding]; other site 568708019521 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568708019522 putative single-stranded DNA-binding protein; Region: PHA01740 568708019524 hypothetical protein; Validated; Region: PRK09039 568708019525 1 probable transmembrane helix predicted for STM_MW42081 by TMHMM2.0 at aa 15-37 568708019526 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 568708019527 Signal peptide predicted for STM_MW42091 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.992 between residues 25 and 26 568708019528 4 probable transmembrane helices predicted for STM_MW42091 by TMHMM2.0 at aa 7-26, 41-63, 131-153 and 186-208 568708019529 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 568708019530 Signal peptide predicted for STM_MW42101 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 19 and 20 568708019532 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 568708019533 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568708019534 HlyD family secretion protein; Region: HlyD_3; pfam13437 568708019535 1 probable transmembrane helix predicted for STM_MW42111 by TMHMM2.0 at aa 12-34 568708019536 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 568708019537 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019538 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019539 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019540 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019541 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019542 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 568708019543 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 568708019544 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019545 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 568708019546 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 568708019547 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019548 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 568708019549 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019550 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 568708019551 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 568708019552 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019553 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 568708019554 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019555 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 568708019556 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 568708019557 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019558 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 568708019559 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 568708019560 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019561 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 568708019562 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019563 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019564 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 568708019565 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019566 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019567 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019568 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019569 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019570 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 568708019571 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019572 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 568708019573 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019574 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 568708019575 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019576 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568708019577 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 568708019578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708019579 Walker A/P-loop; other site 568708019580 ATP binding site [chemical binding]; other site 568708019581 Q-loop/lid; other site 568708019582 ABC transporter signature motif; other site 568708019583 Walker B; other site 568708019584 D-loop; other site 568708019585 H-loop/switch region; other site 568708019586 5 probable transmembrane helices predicted for STM_MW42131 by TMHMM2.0 at aa 157-179, 189-208, 262-284, 288-310 and 376-398 568708019588 2 probable transmembrane helices predicted for STM_MW42141 by TMHMM2.0 at aa 10-29 and 36-58 568708019589 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 568708019590 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 568708019591 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568708019592 Signal peptide predicted for STM_MW42151 by SignalP 2.0 HMM (Signal peptide probability 0.874) with cleavage site probability 0.414 between residues 34 and 35 568708019593 2 probable transmembrane helices predicted for STM_MW42151 by TMHMM2.0 at aa 10-32 and 239-261 568708019595 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 568708019596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708019598 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 568708019599 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 568708019600 DNA binding residues [nucleotide binding] 568708019601 dimer interface [polypeptide binding]; other site 568708019602 [2Fe-2S] cluster binding site [ion binding]; other site 568708019605 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 568708019606 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 568708019607 putative C-terminal domain interface [polypeptide binding]; other site 568708019608 putative GSH binding site (G-site) [chemical binding]; other site 568708019609 putative dimer interface [polypeptide binding]; other site 568708019610 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 568708019611 putative N-terminal domain interface [polypeptide binding]; other site 568708019612 putative dimer interface [polypeptide binding]; other site 568708019613 putative substrate binding pocket (H-site) [chemical binding]; other site 568708019616 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 568708019618 12 probable transmembrane helices predicted for STM_MW42191 by TMHMM2.0 at aa 29-51, 56-78, 85-107, 112-134, 146-165, 175-197, 202-224, 244-266, 329-351, 356-378, 391-413 and 428-447 568708019619 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 568708019620 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 568708019621 9 probable transmembrane helices predicted for STM_MW42201 by TMHMM2.0 at aa 4-26, 86-108, 113-135, 181-203, 233-255, 276-298, 313-335, 361-383 and 398-420 568708019623 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568708019624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708019625 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 568708019626 putative dimerization interface [polypeptide binding]; other site 568708019629 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 568708019630 4 probable transmembrane helices predicted for STM_MW42221 by TMHMM2.0 at aa 20-42, 47-66, 73-95 and 100-122 568708019632 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 568708019633 6 probable transmembrane helices predicted for STM_MW42231 by TMHMM2.0 at aa 4-21, 33-54, 64-86, 93-115, 149-171 and 203-225 568708019635 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 568708019636 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 568708019637 Na binding site [ion binding]; other site 568708019638 13 probable transmembrane helices predicted for STM_MW42241 by TMHMM2.0 at aa 33-55, 76-98, 103-125, 146-168, 183-205, 212-234, 261-283, 303-325, 362-384, 404-423, 428-450, 462-484 and 494-516 568708019640 Signal peptide predicted for STM_MW42241 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19 568708019641 Predicted membrane protein [Function unknown]; Region: COG3162 568708019643 2 probable transmembrane helices predicted for STM_MW42251 by TMHMM2.0 at aa 25-47 and 62-84 568708019644 acetyl-CoA synthetase; Provisional; Region: PRK00174 568708019645 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 568708019646 active site 568708019647 CoA binding site [chemical binding]; other site 568708019648 acyl-activating enzyme (AAE) consensus motif; other site 568708019649 AMP binding site [chemical binding]; other site 568708019650 acetate binding site [chemical binding]; other site 568708019652 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 568708019653 Signal peptide predicted for STM_MW42281 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 26 and 27 568708019655 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 568708019657 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 568708019658 Signal peptide predicted for STM_MW42301 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 27 and 28 568708019660 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 568708019661 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 568708019663 8 probable transmembrane helices predicted for STM_MW42311 by TMHMM2.0 at aa 15-37, 57-76, 91-113, 144-166, 181-203, 224-241, 256-278 and 290-312 568708019664 heme lyase subunit NrfE; Provisional; Region: PRK10369 568708019665 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 568708019666 15 probable transmembrane helices predicted for STM_MW42321 by TMHMM2.0 at aa 13-35, 56-78, 93-115, 127-149, 183-205, 212-234, 254-271, 283-305, 315-337, 357-379, 394-416, 429-448, 552-571, 608-627 and 708-727 568708019669 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 568708019670 1 probable transmembrane helix predicted for STM_MW42331 by TMHMM2.0 at aa 20-37 568708019671 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 568708019672 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 568708019673 8 probable transmembrane helices predicted for STM_MW42341 by TMHMM2.0 at aa 7-29, 49-71, 84-106, 163-185, 206-228, 233-255, 354-376 and 391-409 568708019675 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 568708019676 Sel1-like repeats; Region: SEL1; smart00671 568708019678 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 568708019679 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 568708019680 [4Fe-4S] binding site [ion binding]; other site 568708019681 molybdopterin cofactor binding site; other site 568708019682 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 568708019683 molybdopterin cofactor binding site; other site 568708019687 pfam_scan;Pfam:PF05118; E()=1.6E-62;score=209.3;query 68-222;description=Asp_Arg_Hydrox; tmhmm; query 1-302 568708019689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708019690 Coenzyme A binding pocket [chemical binding]; other site 568708019692 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 568708019693 dimer interface [polypeptide binding]; other site 568708019694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568708019696 hypothetical protein; Provisional; Region: PRK10220 568708019697 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 568708019698 PhnA protein; Region: PhnA; pfam03831 568708019701 proline/glycine betaine transporter; Provisional; Region: PRK10642 568708019702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708019703 putative substrate translocation pore; other site 568708019704 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 568708019706 12 probable transmembrane helices predicted for STM_MW42411 by TMHMM2.0 at aa 30-52, 67-89, 98-120, 124-146, 167-189, 199-221, 260-282, 297-319, 326-346, 351-373, 386-408 and 418-437 568708019708 sensor protein BasS/PmrB; Provisional; Region: PRK10755 568708019709 HAMP domain; Region: HAMP; pfam00672 568708019710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708019711 dimer interface [polypeptide binding]; other site 568708019712 phosphorylation site [posttranslational modification] 568708019713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708019714 ATP binding site [chemical binding]; other site 568708019715 Mg2+ binding site [ion binding]; other site 568708019716 G-X-G motif; other site 568708019719 2 probable transmembrane helices predicted for STM_MW42421 by TMHMM2.0 at aa 13-35 and 66-88 568708019720 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 568708019721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708019722 active site 568708019723 phosphorylation site [posttranslational modification] 568708019724 intermolecular recognition site; other site 568708019725 dimerization interface [polypeptide binding]; other site 568708019726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708019727 DNA binding site [nucleotide binding] 568708019730 putative metal dependent hydrolase; Provisional; Region: PRK11598 568708019731 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 568708019732 Sulfatase; Region: Sulfatase; pfam00884 568708019735 5 probable transmembrane helices predicted for STM_MW42441 by TMHMM2.0 at aa 11-33, 48-70, 77-99, 119-141 and 154-176 568708019736 arginine:agmatin antiporter; Provisional; Region: PRK10644 568708019738 11 probable transmembrane helices predicted for STM_MW42451 by TMHMM2.0 at aa 10-32, 39-61, 94-116, 123-142, 152-173, 228-250, 274-296, 324-341, 356-378, 385-407 and 411-428 568708019739 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 568708019740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708019742 arginine decarboxylase; Provisional; Region: PRK15029 568708019743 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 568708019744 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 568708019745 homodimer interface [polypeptide binding]; other site 568708019746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568708019747 catalytic residue [active] 568708019748 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 568708019752 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 568708019753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708019754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708019756 alpha-galactosidase; Provisional; Region: PRK15076 568708019757 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 568708019758 NAD binding site [chemical binding]; other site 568708019759 sugar binding site [chemical binding]; other site 568708019760 divalent metal binding site [ion binding]; other site 568708019761 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 568708019762 dimer interface [polypeptide binding]; other site 568708019764 melibiose:sodium symporter; Provisional; Region: PRK10429 568708019765 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 568708019766 12 probable transmembrane helices predicted for STM_MW42501 by TMHMM2.0 at aa 9-31, 36-58, 78-100, 110-132, 145-167, 177-199, 236-258, 268-290, 297-319, 324-346, 378-400 and 410-432 568708019767 fumarate hydratase; Provisional; Region: PRK15389 568708019768 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 568708019769 Fumarase C-terminus; Region: Fumerase_C; pfam05683 568708019772 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 568708019773 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 568708019774 11 probable transmembrane helices predicted for STM_MW42521 by TMHMM2.0 at aa 21-43, 53-75, 88-110, 142-164, 171-193, 236-253, 266-288, 303-325, 346-368, 378-400 and 421-443 568708019776 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 568708019777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708019778 active site 568708019779 phosphorylation site [posttranslational modification] 568708019780 intermolecular recognition site; other site 568708019781 dimerization interface [polypeptide binding]; other site 568708019783 sensory histidine kinase DcuS; Provisional; Region: PRK11086 568708019784 PAS domain; Region: PAS; smart00091 568708019785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708019786 ATP binding site [chemical binding]; other site 568708019787 Mg2+ binding site [ion binding]; other site 568708019788 G-X-G motif; other site 568708019790 2 probable transmembrane helices predicted for STM_MW42551 by TMHMM2.0 at aa 20-42 and 183-202 568708019792 Signal peptide predicted for STM_MW42551 by SignalP 2.0 HMM (Signal peptide probability 0.942) with cleavage site probability 0.539 between residues 36 and 37 568708019793 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 568708019794 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 568708019795 putative [Fe4-S4] binding site [ion binding]; other site 568708019796 putative molybdopterin cofactor binding site [chemical binding]; other site 568708019797 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 568708019798 putative molybdopterin cofactor binding site; other site 568708019799 Signal peptide predicted for STM_MW42561 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.988 between residues 43 and 44 568708019803 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 568708019805 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 568708019807 8 probable transmembrane helices predicted for STM_MW42581 by TMHMM2.0 at aa 10-32, 39-61, 81-100, 107-129, 139-161, 166-188, 203-221 and 228-250 568708019808 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 568708019810 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 568708019812 Signal peptide predicted for STM_MW42601 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 568708019813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 568708019814 SdiA-regulated; Region: SdiA-regulated; cd09971 568708019815 putative active site [active] 568708019816 1 probable transmembrane helix predicted for STM_MW42611 by TMHMM2.0 at aa 13-35 568708019818 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568708019819 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708019820 DNA binding residues [nucleotide binding] 568708019821 dimerization interface [polypeptide binding]; other site 568708019823 AraC family transcriptional regulator; Provisional; Region: PRK15186 568708019824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708019826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 568708019828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708019829 Coenzyme A binding pocket [chemical binding]; other site 568708019831 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 568708019832 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 568708019833 active site 568708019835 Signal peptide predicted for STM_MW42691 by SignalP 2.0 HMM (Signal peptide probability 0.856) with cleavage site probability 0.814 between residues 20 and 21 568708019836 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 568708019837 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 568708019838 DNA binding residues [nucleotide binding] 568708019839 putative dimer interface [polypeptide binding]; other site 568708019842 putative transcriptional regulator; Provisional; Region: PRK11640 568708019843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568708019845 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 568708019846 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 568708019847 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 568708019848 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 568708019849 DsbD alpha interface [polypeptide binding]; other site 568708019850 catalytic residues [active] 568708019852 8 probable transmembrane helices predicted for STM_MW42721 by TMHMM2.0 at aa 5-22, 170-192, 212-234, 246-268, 297-319, 326-348, 358-380 and 387-409 568708019855 Signal peptide predicted for STM_MW42721 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 19 and 20 568708019856 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 568708019858 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 568708019859 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 568708019861 10 probable transmembrane helices predicted for STM_MW42741 by TMHMM2.0 at aa 7-29, 49-71, 91-113, 123-145, 187-204, 219-238, 245-267, 287-306, 319-341 and 371-393 568708019862 Signal peptide predicted for STM_MW42741 by SignalP 2.0 HMM (Signal peptide probability 0.795) with cleavage site probability 0.617 between residues 27 and 28 568708019863 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 568708019864 Aspartase; Region: Aspartase; cd01357 568708019865 active sites [active] 568708019866 tetramer interface [polypeptide binding]; other site 568708019869 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 568708019870 3 probable transmembrane helices predicted for STM_MW42761 by TMHMM2.0 at aa 15-34, 39-61 and 92-114 568708019872 putative transporter; Provisional; Region: PRK11021 568708019873 10 probable transmembrane helices predicted for STM_MW42771 by TMHMM2.0 at aa 7-29, 44-66, 87-109, 146-168, 181-203, 223-245, 258-280, 314-336, 343-362 and 372-406 568708019875 Signal peptide predicted for STM_MW42771 by SignalP 2.0 HMM (Signal peptide probability 0.710) with cleavage site probability 0.417 between residues 33 and 34 568708019876 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 568708019877 oligomerisation interface [polypeptide binding]; other site 568708019878 mobile loop; other site 568708019879 roof hairpin; other site 568708019881 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 568708019882 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 568708019883 ring oligomerisation interface [polypeptide binding]; other site 568708019884 ATP/Mg binding site [chemical binding]; other site 568708019885 stacking interactions; other site 568708019886 hinge regions; other site 568708019888 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 568708019889 Signal peptide predicted for STM_MW42801 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.593 between residues 28 and 29 568708019890 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 568708019891 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708019892 FeS/SAM binding site; other site 568708019894 elongation factor P; Validated; Region: PRK00529 568708019895 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 568708019896 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 568708019897 RNA binding site [nucleotide binding]; other site 568708019898 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 568708019899 RNA binding site [nucleotide binding]; other site 568708019903 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 568708019904 Signal peptide predicted for STM_MW42841 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 21 and 22 568708019906 1 probable transmembrane helix predicted for STM_MW42841 by TMHMM2.0 at aa 7-29 568708019907 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568708019908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708019909 DNA binding residues [nucleotide binding] 568708019910 dimerization interface [polypeptide binding]; other site 568708019912 multidrug efflux system protein; Provisional; Region: PRK11431 568708019914 4 probable transmembrane helices predicted for STM_MW42861 by TMHMM2.0 at aa 2-19, 29-48, 55-77 and 87-104 568708019915 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 568708019916 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 568708019918 Signal peptide predicted for STM_MW42871 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.691 between residues 18 and 19 568708019919 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 568708019920 Iron-sulfur protein interface; other site 568708019921 proximal quinone binding site [chemical binding]; other site 568708019922 C-subunit interface; other site 568708019923 distal quinone binding site; other site 568708019924 3 probable transmembrane helices predicted for STM_MW42881 by TMHMM2.0 at aa 13-42, 57-79 and 99-118 568708019926 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 568708019927 D-subunit interface [polypeptide binding]; other site 568708019928 Iron-sulfur protein interface; other site 568708019929 proximal quinone binding site [chemical binding]; other site 568708019931 3 probable transmembrane helices predicted for STM_MW42891 by TMHMM2.0 at aa 28-50, 60-82 and 108-130 568708019932 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 568708019933 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 568708019934 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 568708019935 L-aspartate oxidase; Provisional; Region: PRK06175 568708019936 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 568708019939 Signal peptide predicted for STM_MW42911 by SignalP 2.0 HMM (Signal peptide probability 0.907) with cleavage site probability 0.351 between residues 27 and 28 568708019940 poxB regulator PoxA; Provisional; Region: PRK09350 568708019941 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568708019942 motif 1; other site 568708019943 dimer interface [polypeptide binding]; other site 568708019944 active site 568708019945 motif 2; other site 568708019946 motif 3; other site 568708019948 inner membrane transporter YjeM; Provisional; Region: PRK15238 568708019949 Signal peptide predicted for STM_MW42931 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.891 between residues 25 and 26 568708019950 12 probable transmembrane helices predicted for STM_MW42931 by TMHMM2.0 at aa 12-34, 38-57, 95-117, 132-154, 161-183, 208-230, 243-265, 310-332, 364-383, 393-415, 435-457 and 467-484 568708019952 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 568708019953 Signal peptide predicted for STM_MW42941 by SignalP 2.0 HMM (Signal peptide probability 0.911) with cleavage site probability 0.512 between residues 21 and 22 568708019955 3 probable transmembrane helices predicted for STM_MW42941 by TMHMM2.0 at aa 7-26, 55-72 and 79-98 568708019956 putative mechanosensitive channel protein; Provisional; Region: PRK10929 568708019957 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 568708019958 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568708019959 11 probable transmembrane helices predicted for STM_MW42951 by TMHMM2.0 at aa 475-492, 521-543, 553-575, 596-617, 627-648, 669-691, 696-718, 784-806, 826-848, 879-898 and 908-930 568708019961 Signal peptide predicted for STM_MW42951 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 568708019962 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 568708019964 GTPase RsgA; Reviewed; Region: PRK12288 568708019965 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 568708019966 RNA binding site [nucleotide binding]; other site 568708019967 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 568708019968 GTPase/Zn-binding domain interface [polypeptide binding]; other site 568708019969 GTP/Mg2+ binding site [chemical binding]; other site 568708019970 G4 box; other site 568708019971 G5 box; other site 568708019972 G1 box; other site 568708019973 Switch I region; other site 568708019974 G2 box; other site 568708019975 G3 box; other site 568708019976 Switch II region; other site 568708019978 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 568708019979 catalytic site [active] 568708019980 putative active site [active] 568708019981 putative substrate binding site [chemical binding]; other site 568708019982 dimer interface [polypeptide binding]; other site 568708019984 note framshift follwoign codon 1 within a 8xpoly T tract; pfam_scan;Pfam:PF00497; E()=5.6E-72;score=242.1;query 24-244;description=SBP_bac_3 568708019986 epoxyqueuosine reductase; Region: TIGR00276 568708019987 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 568708019989 putative carbohydrate kinase; Provisional; Region: PRK10565 568708019990 Uncharacterized conserved protein [Function unknown]; Region: COG0062 568708019991 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 568708019992 putative substrate binding site [chemical binding]; other site 568708019993 putative ATP binding site [chemical binding]; other site 568708019996 ADP-binding protein; Provisional; Region: PRK10646 568708019998 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 568708019999 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 568708020000 active site 568708020001 metal binding site [ion binding]; metal-binding site 568708020002 Signal peptide predicted for STM_MW43031 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.949 between residues 22 and 23 568708020004 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 568708020005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708020006 ATP binding site [chemical binding]; other site 568708020007 Mg2+ binding site [ion binding]; other site 568708020008 G-X-G motif; other site 568708020009 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 568708020010 ATP binding site [chemical binding]; other site 568708020011 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 568708020015 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 568708020016 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 568708020018 bacterial Hfq-like; Region: Hfq; cd01716 568708020019 hexamer interface [polypeptide binding]; other site 568708020020 Sm1 motif; other site 568708020021 RNA binding site [nucleotide binding]; other site 568708020022 Sm2 motif; other site 568708020024 GTPase HflX; Provisional; Region: PRK11058 568708020025 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 568708020026 HflX GTPase family; Region: HflX; cd01878 568708020027 G1 box; other site 568708020028 GTP/Mg2+ binding site [chemical binding]; other site 568708020029 Switch I region; other site 568708020030 G2 box; other site 568708020031 G3 box; other site 568708020032 Switch II region; other site 568708020033 G4 box; other site 568708020034 G5 box; other site 568708020037 FtsH protease regulator HflK; Provisional; Region: PRK10930 568708020038 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 568708020039 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 568708020040 1 probable transmembrane helix predicted for STM_MW43081 by TMHMM2.0 at aa 78-100 568708020042 FtsH protease regulator HflC; Provisional; Region: PRK11029 568708020043 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 568708020044 Signal peptide predicted for STM_MW43091 by SignalP 2.0 HMM (Signal peptide probability 0.723) with cleavage site probability 0.456 between residues 24 and 25 568708020045 1 probable transmembrane helix predicted for STM_MW43091 by TMHMM2.0 at aa 5-23 568708020047 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 568708020048 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 568708020049 GDP-binding site [chemical binding]; other site 568708020050 ACT binding site; other site 568708020051 IMP binding site; other site 568708020053 Predicted transcriptional regulator [Transcription]; Region: COG1959 568708020054 transcriptional repressor NsrR; Provisional; Region: PRK11014 568708020056 exoribonuclease R; Provisional; Region: PRK11642 568708020057 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 568708020058 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 568708020059 RNB domain; Region: RNB; pfam00773 568708020060 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 568708020061 RNA binding site [nucleotide binding]; other site 568708020066 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 568708020067 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 568708020068 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568708020071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 568708020073 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 568708020075 Ion channel; Region: Ion_trans_2; pfam07885 568708020076 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 568708020077 3 probable transmembrane helices predicted for STM_MW43161 by TMHMM2.0 at aa 15-37, 44-66 and 81-100 568708020079 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 568708020081 Predicted membrane protein [Function unknown]; Region: COG3766 568708020082 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 568708020083 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 568708020084 4 probable transmembrane helices predicted for STM_MW43181 by TMHMM2.0 at aa 6-28, 48-70, 75-97 and 109-131 568708020086 Predicted integral membrane protein [Function unknown]; Region: COG5463 568708020088 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 568708020090 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 568708020091 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 568708020092 FAD binding site [chemical binding]; other site 568708020093 substrate binding site [chemical binding]; other site 568708020094 catalytic residues [active] 568708020097 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 568708020099 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 568708020101 1 probable transmembrane helix predicted for STM_MW43231 by TMHMM2.0 at aa 13-32 568708020102 Signal peptide predicted for STM_MW43231 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.602 between residues 30 and 31 568708020103 esterase; Provisional; Region: PRK10566 568708020104 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568708020105 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568708020107 transcriptional repressor UlaR; Provisional; Region: PRK13509 568708020108 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 568708020109 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568708020112 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 568708020113 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 568708020114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 568708020115 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 568708020116 10 probable transmembrane helices predicted for STM_MW43271 by TMHMM2.0 at aa 22-44, 51-73, 111-133, 154-183, 244-263, 275-297, 317-339, 351-373, 388-410 and 435-457 568708020118 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 568708020119 active site 568708020120 P-loop; other site 568708020121 phosphorylation site [posttranslational modification] 568708020123 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568708020124 active site 568708020125 phosphorylation site [posttranslational modification] 568708020127 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 568708020128 active site 568708020129 dimer interface [polypeptide binding]; other site 568708020130 magnesium binding site [ion binding]; other site 568708020132 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 568708020133 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 568708020134 AP (apurinic/apyrimidinic) site pocket; other site 568708020135 DNA interaction; other site 568708020136 Metal-binding active site; metal-binding site 568708020138 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 568708020139 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 568708020140 intersubunit interface [polypeptide binding]; other site 568708020141 active site 568708020142 Zn2+ binding site [ion binding]; other site 568708020144 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 568708020146 Signal peptide predicted for STM_MW43331 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.720 between residues 20 and 21 568708020147 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 568708020149 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568708020150 dimer interface [polypeptide binding]; other site 568708020151 ssDNA binding site [nucleotide binding]; other site 568708020152 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568708020154 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 568708020156 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 568708020157 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 568708020158 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 568708020161 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568708020162 EamA-like transporter family; Region: EamA; pfam00892 568708020163 10 probable transmembrane helices predicted for STM_MW43391 by TMHMM2.0 at aa 13-34, 54-72, 85-107, 117-134, 141-163, 173-192, 204-226, 231-253, 258-280 and 284-303 568708020165 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 568708020166 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 568708020169 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 568708020170 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 568708020171 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 568708020174 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 568708020175 12 probable transmembrane helices predicted for STM_MW43421 by TMHMM2.0 at aa 27-44, 49-71, 104-126, 136-158, 165-187, 210-232, 252-274, 289-311, 347-369, 374-396, 417-435 and 439-461 568708020177 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 568708020178 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 568708020179 Hemerythrin-like domain; Region: Hr-like; cd12108 568708020180 Fe binding site [ion binding]; other site 568708020183 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568708020184 EamA-like transporter family; Region: EamA; pfam00892 568708020186 10 probable transmembrane helices predicted for STM_MW43441 by TMHMM2.0 at aa 5-25, 35-52, 64-86, 91-113, 120-142, 152-174, 195-217, 232-254, 259-281 and 286-308 568708020187 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 568708020188 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 568708020189 NADP binding site [chemical binding]; other site 568708020191 Predicted transcriptional regulators [Transcription]; Region: COG1733 568708020192 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 568708020194 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 568708020195 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 568708020196 active site 568708020197 metal binding site [ion binding]; metal-binding site 568708020198 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 568708020201 Signal peptide predicted for STM_MW43471 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 19 and 20 568708020202 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 568708020203 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568708020204 active site 568708020206 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 568708020208 Signal peptide predicted for STM_MW43491 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.887 between residues 20 and 21 568708020209 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 568708020211 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 568708020212 Domain of unknown function DUF21; Region: DUF21; pfam01595 568708020213 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568708020214 Transporter associated domain; Region: CorC_HlyC; smart01091 568708020217 4 probable transmembrane helices predicted for STM_MW43511 by TMHMM2.0 at aa 5-27, 58-80, 100-117 and 144-162 568708020219 Signal peptide predicted for STM_MW43511 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.988 between residues 26 and 27 568708020220 methionine sulfoxide reductase A; Provisional; Region: PRK00058 568708020222 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 568708020223 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568708020224 Surface antigen; Region: Bac_surface_Ag; pfam01103 568708020225 Signal peptide predicted for STM_MW43531 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.967 between residues 21 and 22 568708020228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 568708020229 Family of unknown function (DUF490); Region: DUF490; pfam04357 568708020230 Signal peptide predicted for STM_MW43541 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.711 between residues 25 and 26 568708020231 1 probable transmembrane helix predicted for STM_MW43541 by TMHMM2.0 at aa 7-29 568708020233 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 568708020234 putative active site pocket [active] 568708020235 dimerization interface [polypeptide binding]; other site 568708020236 putative catalytic residue [active] 568708020238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708020239 D-galactonate transporter; Region: 2A0114; TIGR00893 568708020240 putative substrate translocation pore; other site 568708020241 12 probable transmembrane helices predicted for STM_MW43561 by TMHMM2.0 at aa 7-26, 41-63, 76-93, 97-116, 137-154, 164-186, 215-237, 252-273, 280-302, 307-329, 342-364 and 374-393 568708020243 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 568708020244 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 568708020245 active site 568708020247 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 568708020248 dimer interface [polypeptide binding]; other site 568708020249 substrate binding site [chemical binding]; other site 568708020250 metal binding sites [ion binding]; metal-binding site 568708020252 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 568708020253 AMP binding site [chemical binding]; other site 568708020254 metal binding site [ion binding]; metal-binding site 568708020255 active site 568708020257 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 568708020258 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568708020259 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568708020260 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568708020261 Signal peptide predicted for STM_MW43601 by SignalP 2.0 HMM (Signal peptide probability 0.966) with cleavage site probability 0.924 between residues 24 and 25 568708020265 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568708020266 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568708020267 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568708020268 putative active site [active] 568708020271 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 568708020272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708020273 putative substrate translocation pore; other site 568708020274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708020276 12 probable transmembrane helices predicted for STM_MW43621 by TMHMM2.0 at aa 12-34, 54-73, 85-107, 111-133, 146-165, 175-197, 257-279, 294-316, 323-345, 355-377, 389-408 and 423-445 568708020277 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 568708020278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708020279 putative substrate translocation pore; other site 568708020280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708020281 Signal peptide predicted for STM_MW43631 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.955 between residues 31 and 32 568708020282 12 probable transmembrane helices predicted for STM_MW43631 by TMHMM2.0 at aa 12-34, 49-68, 81-100, 105-127, 140-162, 177-196, 260-282, 297-319, 326-345, 355-377, 390-412 and 422-444 568708020284 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 568708020286 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 568708020287 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 568708020288 tetrameric interface [polypeptide binding]; other site 568708020289 NAD binding site [chemical binding]; other site 568708020290 catalytic residues [active] 568708020292 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 568708020293 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568708020294 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708020297 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568708020299 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568708020300 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568708020301 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568708020304 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 568708020305 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 568708020307 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568708020309 major facilitator superfamily transporter; Provisional; Region: PRK05122 568708020310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708020311 putative substrate translocation pore; other site 568708020312 12 probable transmembrane helices predicted for STM_MW43721 by TMHMM2.0 at aa 12-34, 49-68, 89-111, 116-138, 145-167, 177-199, 212-234, 249-266, 273-295, 299-321, 334-356 and 366-385 568708020314 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568708020315 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568708020316 substrate binding site [chemical binding]; other site 568708020317 ATP binding site [chemical binding]; other site 568708020318 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 568708020319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 568708020322 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 568708020323 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568708020324 PYR/PP interface [polypeptide binding]; other site 568708020325 dimer interface [polypeptide binding]; other site 568708020326 TPP binding site [chemical binding]; other site 568708020327 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568708020328 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 568708020329 TPP-binding site; other site 568708020333 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568708020334 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568708020335 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568708020338 polyol permease family; Region: 2A0118; TIGR00897 568708020339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708020340 putative substrate translocation pore; other site 568708020341 12 probable transmembrane helices predicted for STM_MW43761 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 110-132, 145-167, 177-196, 231-253, 263-282, 295-317, 322-344, 357-379 and 383-402 568708020343 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 568708020344 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 568708020345 DNA interaction; other site 568708020346 Metal-binding active site; metal-binding site 568708020348 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 568708020350 hypothetical protein; Provisional; Region: PRK05255 568708020352 peptidase PmbA; Provisional; Region: PRK11040 568708020354 cytochrome b562; Provisional; Region: PRK15058 568708020355 Signal peptide predicted for STM_MW43811 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708020356 1 probable transmembrane helix predicted for STM_MW43811 by TMHMM2.0 at aa 5-23 568708020358 match to SC4294 1..39 blast score 73.2 percent identity 82 SC4294 hypothetical protein 4598157:4598312 forward MW:5627; match to SC4294 38..51 blast score 31.2 percent identity 100 SC4294 hypothetical protein 4598157:4598312 forward MW:5627; tmhmm; query 1-47 568708020359 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 568708020361 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 568708020362 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 568708020363 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 568708020364 Signal peptide predicted for STM_MW43861 by SignalP 2.0 HMM (Signal peptide probability 0.850) with cleavage site probability 0.565 between residues 24 and 25 568708020365 6 probable transmembrane helices predicted for STM_MW43861 by TMHMM2.0 at aa 2-24, 55-77, 111-133, 143-165, 177-199 and 214-232 568708020366 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 568708020367 6 probable transmembrane helices predicted for STM_MW43871 by TMHMM2.0 at aa 15-37, 57-74, 84-106, 111-133, 165-187 and 194-213 568708020368 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 568708020369 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 568708020370 active site 568708020372 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 568708020373 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 568708020375 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 568708020377 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568708020378 HTH domain; Region: HTH_11; pfam08279 568708020379 Mga helix-turn-helix domain; Region: Mga; pfam05043 568708020380 PRD domain; Region: PRD; pfam00874 568708020381 PRD domain; Region: PRD; pfam00874 568708020382 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568708020383 active site 568708020384 P-loop; other site 568708020385 phosphorylation site [posttranslational modification] 568708020386 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568708020387 active site 568708020388 phosphorylation site [posttranslational modification] 568708020393 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 568708020395 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 568708020397 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 568708020398 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708020399 FeS/SAM binding site; other site 568708020400 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 568708020401 ATP cone domain; Region: ATP-cone; pfam03477 568708020402 Class III ribonucleotide reductase; Region: RNR_III; cd01675 568708020403 effector binding site; other site 568708020404 active site 568708020405 Zn binding site [ion binding]; other site 568708020406 glycine loop; other site 568708020409 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 568708020410 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 568708020411 Ca binding site [ion binding]; other site 568708020412 active site 568708020413 catalytic site [active] 568708020414 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 568708020416 pfam_scan;Pfam:PF00367; E()=5.9E-11;score=41.1;query11-41;description=PTS_EIIB; pfam_scan;Pfam:PF02378; E()=2.4E-34;score=118.5;query 112-404;description=PTS_EIIC; tmhmm; query 1-473 568708020419 trehalose repressor; Provisional; Region: treR; PRK09492 568708020420 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708020421 DNA binding site [nucleotide binding] 568708020422 domain linker motif; other site 568708020423 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 568708020424 dimerization interface [polypeptide binding]; other site 568708020425 ligand binding site [chemical binding]; other site 568708020428 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 568708020429 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 568708020430 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568708020431 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568708020432 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 568708020433 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568708020434 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568708020436 8 probable transmembrane helices predicted for STM_MW44011 by TMHMM2.0 at aa 122-141, 295-314, 324-346, 714-736, 773-795, 808-827, 842-864 and 869-891 568708020440 Transposase; Region: HTH_Tnp_1; cl17663 568708020442 2 probable transmembrane helices predicted for STM_MW44021 by TMHMM2.0 at aa 59-78 and 82-101 568708020443 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568708020444 homotrimer interaction site [polypeptide binding]; other site 568708020445 putative active site [active] 568708020447 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 568708020448 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 568708020449 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 568708020452 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 568708020453 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 568708020454 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 568708020457 pyrBI operon leader peptide; Provisional; Region: PRK10224 568708020459 Arginine repressor [Transcription]; Region: ArgR; COG1438 568708020460 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 568708020461 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 568708020464 Predicted membrane protein [Function unknown]; Region: COG1288 568708020465 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 568708020466 11 probable transmembrane helices predicted for STM_MW44091 by TMHMM2.0 at aa 7-29, 76-98, 121-140, 162-184, 205-222, 263-285, 290-307, 322-339, 371-393, 413-435 and 442-464 568708020468 Signal peptide predicted for STM_MW44091 by SignalP 2.0 HMM (Signal peptide probability 0.708) with cleavage site probability 0.265 between residues 24 and 25 568708020469 ornithine carbamoyltransferase; Validated; Region: PRK02102 568708020470 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 568708020471 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 568708020474 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 568708020475 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 568708020476 putative substrate binding site [chemical binding]; other site 568708020477 nucleotide binding site [chemical binding]; other site 568708020478 nucleotide binding site [chemical binding]; other site 568708020479 homodimer interface [polypeptide binding]; other site 568708020481 arginine deiminase; Provisional; Region: PRK01388 568708020483 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 568708020485 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 568708020486 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 568708020487 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 568708020490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 568708020491 RNase E inhibitor protein; Provisional; Region: PRK11191 568708020493 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 568708020494 active site 568708020495 dinuclear metal binding site [ion binding]; other site 568708020496 dimerization interface [polypeptide binding]; other site 568708020498 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 568708020499 Signal peptide predicted for STM_MW44181 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.993 between residues 22 and 23 568708020500 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568708020501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708020502 Coenzyme A binding pocket [chemical binding]; other site 568708020504 Predicted membrane protein [Function unknown]; Region: COG4269 568708020506 8 probable transmembrane helices predicted for STM_MW44201 by TMHMM2.0 at aa 24-46, 67-89, 99-121, 142-164, 169-191, 229-251, 281-303 and 324-346 568708020507 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 568708020508 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 568708020509 HIGH motif; other site 568708020510 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568708020511 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 568708020512 active site 568708020513 KMSKS motif; other site 568708020514 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 568708020515 tRNA binding surface [nucleotide binding]; other site 568708020516 anticodon binding site; other site 568708020517 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 568708020521 DNA polymerase III subunit chi; Validated; Region: PRK05728 568708020523 multifunctional aminopeptidase A; Provisional; Region: PRK00913 568708020524 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 568708020525 interface (dimer of trimers) [polypeptide binding]; other site 568708020526 Substrate-binding/catalytic site; other site 568708020527 Zn-binding sites [ion binding]; other site 568708020530 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 568708020531 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 568708020533 6 probable transmembrane helices predicted for STM_MW44251 by TMHMM2.0 at aa 17-39, 54-76, 97-119, 267-289, 296-313 and 328-348 568708020534 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 568708020535 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 568708020537 6 probable transmembrane helices predicted for STM_MW44261 by TMHMM2.0 at aa 10-32, 64-83, 103-125, 279-301, 305-322 and 329-351 568708020538 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 568708020539 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568708020540 DNA binding site [nucleotide binding] 568708020541 domain linker motif; other site 568708020542 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 568708020543 putative dimerization interface [polypeptide binding]; other site 568708020544 putative ligand binding site [chemical binding]; other site 568708020547 gluconate transporter; Region: gntP; TIGR00791 568708020548 fructuronate transporter; Provisional; Region: PRK10034; cl15264 568708020550 11 probable transmembrane helices predicted for STM_MW44281 by TMHMM2.0 at aa 20-42, 66-88, 92-114, 138-160, 186-208, 221-243, 258-279, 291-313, 317-339, 346-368 and 383-405 568708020551 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 568708020552 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 568708020553 NADP binding site [chemical binding]; other site 568708020554 homodimer interface [polypeptide binding]; other site 568708020555 active site 568708020557 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 568708020558 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 568708020559 putative NAD(P) binding site [chemical binding]; other site 568708020560 catalytic Zn binding site [ion binding]; other site 568708020563 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 568708020564 ATP-binding site [chemical binding]; other site 568708020565 Gluconate-6-phosphate binding site [chemical binding]; other site 568708020567 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 568708020568 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 568708020569 putative NAD(P) binding site [chemical binding]; other site 568708020570 putative substrate binding site [chemical binding]; other site 568708020571 catalytic Zn binding site [ion binding]; other site 568708020572 structural Zn binding site [ion binding]; other site 568708020573 dimer interface [polypeptide binding]; other site 568708020577 Part of AAA domain; Region: AAA_19; pfam13245 568708020578 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 568708020579 AAA domain; Region: AAA_12; pfam13087 568708020580 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 568708020581 putative active site [active] 568708020582 catalytic site [active] 568708020583 Uncharacterized conserved protein [Function unknown]; Region: COG4127 568708020584 Restriction endonuclease; Region: Mrr_cat; pfam04471 568708020586 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 568708020587 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 568708020589 TIGR02687 family protein; Region: TIGR02687 568708020590 PglZ domain; Region: PglZ; pfam08665 568708020592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708020593 AAA domain; Region: AAA_21; pfam13304 568708020594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568708020595 Walker A/P-loop; other site 568708020596 Walker A/P-loop; other site 568708020597 ATP binding site [chemical binding]; other site 568708020598 ATP binding site [chemical binding]; other site 568708020599 Q-loop/lid; other site 568708020601 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 568708020602 Methyltransferase domain; Region: Methyltransf_26; pfam13659 568708020604 TIGR02680 family protein; Region: TIGR02680 568708020606 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 568708020608 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 568708020611 hypothetical protein; Provisional; Region: PRK12378 568708020613 Methyltransferase domain; Region: Methyltransf_23; pfam13489 568708020614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708020615 S-adenosylmethionine binding site [chemical binding]; other site 568708020616 Methyltransferase domain; Region: Methyltransf_31; pfam13847 568708020617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708020618 S-adenosylmethionine binding site [chemical binding]; other site 568708020620 hypothetical protein; Provisional; Region: PRK13687 568708020622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332 568708020624 Uncharacterized conserved protein [Function unknown]; Region: COG3439 568708020625 Signal peptide predicted for STM_MW44511 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.978 between residues 24 and 25 568708020627 Dienelactone hydrolase family; Region: DLH; pfam01738 568708020629 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 568708020630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568708020631 DNA-binding site [nucleotide binding]; DNA binding site 568708020632 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568708020635 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 568708020636 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 568708020637 active site 568708020638 HIGH motif; other site 568708020639 dimer interface [polypeptide binding]; other site 568708020640 KMSKS motif; other site 568708020642 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 568708020644 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 568708020645 aspartate racemase; Region: asp_race; TIGR00035 568708020646 Signal peptide predicted for STM_MW44561 by SignalP 2.0 HMM (Signal peptide probability 0.753) with cleavage site probability 0.564 between residues 17 and 18 568708020648 cell density-dependent motility repressor; Provisional; Region: PRK10082 568708020649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568708020650 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568708020651 dimerization interface [polypeptide binding]; other site 568708020654 isoaspartyl dipeptidase; Provisional; Region: PRK10657 568708020655 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568708020656 active site 568708020658 hypothetical protein; Provisional; Region: PRK10519 568708020659 3 probable transmembrane helices predicted for STM_MW44591 by TMHMM2.0 at aa 20-42, 68-90 and 130-152 568708020661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 568708020662 Nucleoside recognition; Region: Gate; pfam07670 568708020663 5 probable transmembrane helices predicted for STM_MW44601 by TMHMM2.0 at aa 37-59, 92-114, 146-165, 180-202 and 246-268 568708020665 tmhmm; query 1-125 568708020666 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 568708020667 12 probable transmembrane helices predicted for STM_MW44621 by TMHMM2.0 at aa 13-35, 55-77, 84-103, 108-130, 137-159, 169-191, 212-234, 244-266, 271-293, 298-320, 333-355 and 360-382 568708020669 Predicted membrane protein [Function unknown]; Region: COG2733 568708020670 3 probable transmembrane helices predicted for STM_MW44631 by TMHMM2.0 at aa 13-32, 42-62 and 398-420 568708020672 Signal peptide predicted for STM_MW44631 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.294 between residues 42 and 43 568708020673 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 568708020674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568708020675 putative substrate translocation pore; other site 568708020676 12 probable transmembrane helices predicted for STM_MW44641 by TMHMM2.0 at aa 13-35, 50-72, 84-103, 107-129, 141-163, 167-189, 219-241, 256-278, 290-312, 316-338, 350-372 and 376-398 568708020678 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 568708020680 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 568708020681 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 568708020682 NAD(P) binding site [chemical binding]; other site 568708020683 catalytic residues [active] 568708020685 5 probable transmembrane helices predicted for STM_MW44681 by TMHMM2.0 at aa 17-39, 54-76, 103-125, 140-162 and 169-191 568708020686 endoribonuclease SymE; Provisional; Region: PRK13605 568708020688 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 568708020689 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 568708020690 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 568708020692 HsdM N-terminal domain; Region: HsdM_N; pfam12161 568708020693 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 568708020694 Methyltransferase domain; Region: Methyltransf_26; pfam13659 568708020696 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 568708020697 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 568708020698 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 568708020699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568708020700 ATP binding site [chemical binding]; other site 568708020701 putative Mg++ binding site [ion binding]; other site 568708020705 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 568708020706 Mrr N-terminal domain; Region: Mrr_N; pfam14338 568708020707 Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030 568708020708 Restriction endonuclease; Region: Mrr_cat; pfam04471 568708020710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 568708020712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 568708020713 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 568708020714 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 568708020715 P-loop, Walker A motif; other site 568708020716 Base recognition motif; other site 568708020717 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 568708020720 Uncharacterized small protein [Function unknown]; Region: COG2879 568708020722 carbon starvation protein A; Provisional; Region: PRK15015 568708020723 Carbon starvation protein CstA; Region: CstA; pfam02554 568708020724 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 568708020725 16 probable transmembrane helices predicted for STM_MW44781 by TMHMM2.0 at aa 12-29, 34-56, 89-111, 121-140, 161-183, 193-215, 220-242, 257-279, 286-305, 325-347, 364-386, 486-505, 532-551, 566-588, 595-617 and 662-684 568708020727 Signal peptide predicted for STM_MW44781 by SignalP 2.0 HMM (Signal peptide probability 0.638) with cleavage site probability 0.612 between residues 27 and 28 568708020728 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 568708020729 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 568708020730 dimer interface [polypeptide binding]; other site 568708020731 ligand binding site [chemical binding]; other site 568708020732 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568708020733 dimerization interface [polypeptide binding]; other site 568708020734 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568708020735 dimer interface [polypeptide binding]; other site 568708020736 putative CheW interface [polypeptide binding]; other site 568708020737 Signal peptide predicted for STM_MW44791 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.327 between residues 25 and 26 568708020738 2 probable transmembrane helices predicted for STM_MW44791 by TMHMM2.0 at aa 7-29 and 192-214 568708020742 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 568708020743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708020744 Walker A motif; other site 568708020745 ATP binding site [chemical binding]; other site 568708020746 Walker B motif; other site 568708020747 arginine finger; other site 568708020748 Transcriptional antiterminator [Transcription]; Region: COG3933 568708020749 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568708020750 active pocket/dimerization site; other site 568708020751 active site 568708020752 phosphorylation site [posttranslational modification] 568708020753 PRD domain; Region: PRD; pfam00874 568708020757 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568708020758 active pocket/dimerization site; other site 568708020759 active site 568708020760 phosphorylation site [posttranslational modification] 568708020762 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 568708020763 active site 568708020764 phosphorylation site [posttranslational modification] 568708020766 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 568708020767 Signal peptide predicted for STM_MW44831 by SignalP 2.0 HMM (Signal peptide probability 0.641) with cleavage site probability 0.472 between residues 19 and 20 568708020769 7 probable transmembrane helices predicted for STM_MW44831 by TMHMM2.0 at aa 7-29, 44-63, 70-92, 96-118, 138-160, 180-199 and 206-235 568708020770 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 568708020772 6 probable transmembrane helices predicted for STM_MW44841 by TMHMM2.0 at aa 69-91, 111-133, 146-168, 197-219, 231-253 and 258-277 568708020773 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 568708020774 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568708020775 dimer interface [polypeptide binding]; other site 568708020776 active site 568708020777 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 568708020778 dimer interface [polypeptide binding]; other site 568708020779 active site 568708020781 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 568708020782 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 568708020783 putative active site [active] 568708020784 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 568708020786 phosphoglycerol transferase I; Provisional; Region: PRK03776 568708020787 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 568708020789 2 probable transmembrane helices predicted for STM_MW44871 by TMHMM2.0 at aa 43-65 and 77-99 568708020790 hypothetical protein; Provisional; Region: PRK11667 568708020792 1 probable transmembrane helix predicted for STM_MW44881 by TMHMM2.0 at aa 7-29 568708020793 Signal peptide predicted for STM_MW44881 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.427 between residues 24 and 25 568708020794 DNA replication protein DnaC; Validated; Region: PRK07952 568708020795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568708020796 Walker A motif; other site 568708020797 ATP binding site [chemical binding]; other site 568708020798 Walker B motif; other site 568708020800 primosomal protein DnaI; Provisional; Region: PRK02854 568708020801 hypothetical protein; Provisional; Region: PRK09917 568708020802 4 probable transmembrane helices predicted for STM_MW44911 by TMHMM2.0 at aa 7-29, 53-75, 87-109 and 129-151 568708020804 Uncharacterized conserved protein [Function unknown]; Region: COG2966 568708020805 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 568708020806 4 probable transmembrane helices predicted for STM_MW44921 by TMHMM2.0 at aa 184-201, 214-236, 241-263 and 276-298 568708020808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568708020809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708020810 DNA binding residues [nucleotide binding] 568708020811 dimerization interface [polypeptide binding]; other site 568708020813 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 568708020814 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568708020815 DNA binding residues [nucleotide binding] 568708020817 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 568708020818 putative deacylase active site [active] 568708020820 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 568708020821 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 568708020822 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 568708020825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568708020826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568708020827 metal binding site [ion binding]; metal-binding site 568708020828 active site 568708020829 I-site; other site 568708020831 5 probable transmembrane helices predicted for STM_MW44971 by TMHMM2.0 at aa 21-40, 45-62, 69-86, 101-123 and 144-163 568708020832 Signal peptide predicted for STM_MW44971 by SignalP 2.0 HMM (Signal peptide probability 0.713) with cleavage site probability 0.283 between residues 34 and 35 568708020833 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 568708020835 3 probable transmembrane helices predicted for STM_MW44981 by TMHMM2.0 at aa 5-27, 31-48 and 55-72 568708020836 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 568708020837 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 568708020838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568708020839 S-adenosylmethionine binding site [chemical binding]; other site 568708020842 DNA polymerase III subunit psi; Validated; Region: PRK06856 568708020844 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 568708020845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568708020846 Coenzyme A binding pocket [chemical binding]; other site 568708020848 dUMP phosphatase; Provisional; Region: PRK09449 568708020849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708020850 motif II; other site 568708020852 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 568708020853 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 568708020854 G1 box; other site 568708020855 putative GEF interaction site [polypeptide binding]; other site 568708020856 GTP/Mg2+ binding site [chemical binding]; other site 568708020857 Switch I region; other site 568708020858 G2 box; other site 568708020859 G3 box; other site 568708020860 Switch II region; other site 568708020861 G4 box; other site 568708020862 G5 box; other site 568708020863 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 568708020866 periplasmic protein; Provisional; Region: PRK10568 568708020867 BON domain; Region: BON; pfam04972 568708020868 Signal peptide predicted for STM_MW45041 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 28 and 29 568708020870 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 568708020871 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 568708020872 active site 568708020873 nucleophile elbow; other site 568708020875 pfam_scan;Pfam:PF01026; E()=4.9E-75;score=251.6;query 6-255;description=TatD_DNase 568708020877 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 568708020878 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568708020879 FeS/SAM binding site; other site 568708020882 hypothetical protein; Provisional; Region: PRK10977 568708020883 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 568708020885 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 568708020886 intersubunit interface [polypeptide binding]; other site 568708020887 active site 568708020888 catalytic residue [active] 568708020890 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 568708020891 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 568708020892 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 568708020893 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 568708020897 phosphopentomutase; Provisional; Region: PRK05362 568708020898 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 568708020901 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 568708020902 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 568708020904 hypothetical protein; Provisional; Region: PRK15301 568708020905 Signal peptide predicted for STM_MW45131 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 26 and 27 568708020906 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 568708020907 PapC N-terminal domain; Region: PapC_N; pfam13954 568708020908 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568708020909 PapC C-terminal domain; Region: PapC_C; pfam13953 568708020911 Signal peptide predicted for STM_MW45141 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 27 and 28 568708020912 putative fimbrial chaperone protein; Provisional; Region: PRK09918 568708020913 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708020914 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708020917 Signal peptide predicted for STM_MW45161 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.820 between residues 27 and 28 568708020918 hypothetical protein; Provisional; Region: PRK15302 568708020920 Signal peptide predicted for STM_MW45171 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.969 between residues 21 and 22 568708020921 hypothetical protein; Provisional; Region: PRK15303 568708020923 Signal peptide predicted for STM_MW45181 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 568708020924 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 568708020925 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 568708020926 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 568708020929 hypothetical protein; Provisional; Region: PRK11246 568708020931 2 probable transmembrane helices predicted for STM_MW45201 by TMHMM2.0 at aa 13-32 and 162-184 568708020932 Signal peptide predicted for STM_MW45201 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.852 between residues 30 and 31 568708020933 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 568708020934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568708020935 motif II; other site 568708020937 DNA repair protein RadA; Region: sms; TIGR00416 568708020938 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 568708020939 Walker A motif/ATP binding site; other site 568708020940 ATP binding site [chemical binding]; other site 568708020941 Walker B motif; other site 568708020942 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 568708020945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568708020946 non-specific DNA binding site [nucleotide binding]; other site 568708020947 salt bridge; other site 568708020948 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 568708020949 sequence-specific DNA binding site [nucleotide binding]; other site 568708020950 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 568708020951 active site 568708020952 (T/H)XGH motif; other site 568708020953 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 568708020955 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 568708020956 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568708020957 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568708020958 ABC transporter; Region: ABC_tran_2; pfam12848 568708020959 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568708020961 lytic murein transglycosylase; Provisional; Region: PRK11619 568708020962 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568708020963 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568708020964 catalytic residue [active] 568708020965 Signal peptide predicted for STM_MW45251 by SignalP 2.0 HMM (Signal peptide probability 0.726) with cleavage site probability 0.725 between residues 39 and 40 568708020967 Trp operon repressor; Provisional; Region: PRK01381 568708020969 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 568708020971 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568708020972 catalytic core [active] 568708020974 1 probable transmembrane helix predicted for STM_MW45281 by TMHMM2.0 at aa 146-168 568708020975 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 568708020976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568708020977 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 568708020980 hypothetical protein; Provisional; Region: PRK10756 568708020981 CreA protein; Region: CreA; pfam05981 568708020982 Signal peptide predicted for STM_MW45301 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 568708020984 DNA-binding response regulator CreB; Provisional; Region: PRK11083 568708020985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708020986 active site 568708020987 phosphorylation site [posttranslational modification] 568708020988 intermolecular recognition site; other site 568708020989 dimerization interface [polypeptide binding]; other site 568708020990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708020991 DNA binding site [nucleotide binding] 568708020994 sensory histidine kinase CreC; Provisional; Region: PRK11100 568708020995 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 568708020996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568708020997 dimer interface [polypeptide binding]; other site 568708020998 phosphorylation site [posttranslational modification] 568708020999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568708021000 ATP binding site [chemical binding]; other site 568708021001 Mg2+ binding site [ion binding]; other site 568708021002 G-X-G motif; other site 568708021003 Signal peptide predicted for STM_MW45321 by SignalP 2.0 HMM (Signal peptide probability 0.859) with cleavage site probability 0.597 between residues 27 and 28 568708021004 2 probable transmembrane helices predicted for STM_MW45321 by TMHMM2.0 at aa 5-27 and 184-206 568708021007 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 568708021009 6 probable transmembrane helices predicted for STM_MW45331 by TMHMM2.0 at aa 10-32, 298-317, 321-343, 350-372, 377-396 and 403-420 568708021010 putative major fimbrial protein SthE; Provisional; Region: PRK15292 568708021011 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 568708021013 Signal peptide predicted for STM_MW45341 by SignalP 2.0 HMM (Signal peptide probability 0.952) with cleavage site probability 0.902 between residues 20 and 21 568708021014 putative fimbrial protein SthD; Provisional; Region: PRK15293 568708021016 1 probable transmembrane helix predicted for STM_MW45351 by TMHMM2.0 at aa 7-29 568708021017 Signal peptide predicted for STM_MW45351 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.614 between residues 27 and 28 568708021018 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 568708021019 PapC N-terminal domain; Region: PapC_N; pfam13954 568708021020 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568708021021 PapC C-terminal domain; Region: PapC_C; pfam13953 568708021023 Signal peptide predicted for STM_MW45361 by SignalP 2.0 HMM (Signal peptide probability 0.848) with cleavage site probability 0.847 between residues 28 and 29 568708021024 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 568708021025 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568708021026 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568708021029 Signal peptide predicted for STM_MW45371 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 20 and 21 568708021030 putative fimbrial protein SthA; Provisional; Region: PRK15296 568708021032 Signal peptide predicted for STM_MW45381 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 568708021033 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 568708021034 Helix-turn-helix domain; Region: HTH_36; pfam13730 568708021035 tmhmm; query 1-166 568708021036 two-component response regulator; Provisional; Region: PRK11173 568708021037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568708021038 active site 568708021039 phosphorylation site [posttranslational modification] 568708021040 intermolecular recognition site; other site 568708021041 dimerization interface [polypeptide binding]; other site 568708021042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568708021043 DNA binding site [nucleotide binding] 568708021046 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 568708021047 putative RNA methyltransferase; Provisional; Region: PRK10433