-- dump date   	20140620_055250
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
99287000001	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
99287000002	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
99287000003	putative catalytic residues [active]
99287000004	putative nucleotide binding site [chemical binding]; other site
99287000005	putative aspartate binding site [chemical binding]; other site
99287000006	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
99287000007	dimer interface [polypeptide binding]; other site
99287000008	putative threonine allosteric regulatory site; other site
99287000009	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
99287000010	putative threonine allosteric regulatory site; other site
99287000011	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
99287000012	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
99287000013	homoserine kinase; Provisional; Region: PRK01212
99287000014	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
99287000015	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
99287000016	threonine synthase; Validated; Region: PRK09225
99287000017	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
99287000018	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99287000019	catalytic residue [active]
99287000020	hypothetical protein; Validated; Region: PRK02101
99287000021	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
99287000022	transaldolase-like protein; Provisional; Region: PTZ00411
99287000023	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
99287000024	active site
99287000025	dimer interface [polypeptide binding]; other site
99287000026	catalytic residue [active]
99287000027	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
99287000028	MPT binding site; other site
99287000029	trimer interface [polypeptide binding]; other site
99287000030	hypothetical protein; Provisional; Region: PRK10659
99287000031	hypothetical protein; Provisional; Region: PRK10236
99287000032	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
99287000033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
99287000034	Protein of unknown function (DUF2541); Region: DUF2541; pfam10807
99287000035	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
99287000036	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
99287000037	nucleotide binding site [chemical binding]; other site
99287000038	NEF interaction site [polypeptide binding]; other site
99287000039	SBD interface [polypeptide binding]; other site
99287000040	chaperone protein DnaJ; Provisional; Region: PRK10767
99287000041	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99287000042	HSP70 interaction site [polypeptide binding]; other site
99287000043	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
99287000044	substrate binding site [polypeptide binding]; other site
99287000045	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
99287000046	Zn binding sites [ion binding]; other site
99287000047	dimer interface [polypeptide binding]; other site
99287000048	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287000049	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287000050	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287000051	dimerization interface [polypeptide binding]; other site
99287000052	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
99287000053	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
99287000054	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
99287000055	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
99287000056	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
99287000057	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
99287000058	active site
99287000059	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
99287000060	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
99287000061	aromatic chitin/cellulose binding site residues [chemical binding]; other site
99287000062	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99287000063	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
99287000064	fimbrial protein BcfA; Provisional; Region: PRK15187
99287000065	fimbrial chaperone protein BcfB; Provisional; Region: PRK15188
99287000066	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287000067	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287000068	outer membrane usher protein; Provisional; Region: PRK15193
99287000069	PapC N-terminal domain; Region: PapC_N; pfam13954
99287000070	Outer membrane usher protein; Region: Usher; pfam00577
99287000071	PapC C-terminal domain; Region: PapC_C; pfam13953
99287000072	fimbrial protein BcfD; Provisional; Region: PRK15189
99287000073	fimbrial protein BcfE; Provisional; Region: PRK15190
99287000074	fimbrial protein BcfF; Provisional; Region: PRK15191
99287000075	fimbrial chaperone BcfG; Provisional; Region: PRK15192
99287000076	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287000077	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287000078	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
99287000079	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
99287000080	catalytic residues [active]
99287000081	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
99287000082	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287000083	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287000084	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287000085	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
99287000086	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
99287000087	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
99287000088	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
99287000089	active site
99287000090	metal binding site [ion binding]; metal-binding site
99287000091	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
99287000092	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
99287000093	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
99287000094	Sulfatase; Region: Sulfatase; pfam00884
99287000095	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
99287000096	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287000097	FeS/SAM binding site; other site
99287000098	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
99287000099	Zinc ribbon domain; Region: Zn-ribbon_8; cl00993
99287000100	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
99287000101	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
99287000102	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
99287000103	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
99287000104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287000105	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
99287000106	putative dimerization interface [polypeptide binding]; other site
99287000107	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
99287000108	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
99287000109	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
99287000110	putative active site [active]
99287000111	putative catalytic site [active]
99287000112	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
99287000113	putative symporter YagG; Provisional; Region: PRK09669; cl15392
99287000114	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
99287000115	Protein of unknown function (DUF2575); Region: DUF2575; pfam10837
99287000116	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
99287000117	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
99287000118	active site
99287000119	Riboflavin kinase; Region: Flavokinase; smart00904
99287000120	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
99287000121	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
99287000122	active site
99287000123	HIGH motif; other site
99287000124	KMSKS motif; other site
99287000125	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
99287000126	tRNA binding surface [nucleotide binding]; other site
99287000127	anticodon binding site; other site
99287000128	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
99287000129	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
99287000130	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
99287000131	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
99287000132	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
99287000133	Fe-S cluster binding site [ion binding]; other site
99287000134	substrate binding site [chemical binding]; other site
99287000135	catalytic site [active]
99287000136	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
99287000137	active site
99287000138	tetramer interface [polypeptide binding]; other site
99287000139	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
99287000140	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287000141	active site
99287000142	phosphorylation site [posttranslational modification]
99287000143	intermolecular recognition site; other site
99287000144	dimerization interface [polypeptide binding]; other site
99287000145	Transcriptional regulator; Region: CitT; pfam12431
99287000146	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
99287000147	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
99287000148	PAS domain; Region: PAS; smart00091
99287000149	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
99287000150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287000151	ATP binding site [chemical binding]; other site
99287000152	Mg2+ binding site [ion binding]; other site
99287000153	G-X-G motif; other site
99287000154	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15477
99287000155	oxaloacetate decarboxylase; Provisional; Region: PRK14040
99287000156	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
99287000157	active site
99287000158	catalytic residues [active]
99287000159	metal binding site [ion binding]; metal-binding site
99287000160	homodimer binding site [polypeptide binding]; other site
99287000161	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
99287000162	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
99287000163	carboxyltransferase (CT) interaction site; other site
99287000164	biotinylation site [posttranslational modification]; other site
99287000165	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
99287000166	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
99287000167	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
99287000168	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
99287000169	putative active site [active]
99287000170	(T/H)XGH motif; other site
99287000171	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
99287000172	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
99287000173	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
99287000174	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
99287000175	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
99287000176	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
99287000177	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
99287000178	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
99287000179	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
99287000180	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
99287000181	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
99287000182	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
99287000183	catalytic site [active]
99287000184	subunit interface [polypeptide binding]; other site
99287000185	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
99287000186	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
99287000187	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
99287000188	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
99287000189	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
99287000190	ATP-grasp domain; Region: ATP-grasp_4; cl17255
99287000191	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
99287000192	IMP binding site; other site
99287000193	dimer interface [polypeptide binding]; other site
99287000194	interdomain contacts; other site
99287000195	partial ornithine binding site; other site
99287000196	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
99287000197	carnitine operon protein CaiE; Provisional; Region: PRK13627
99287000198	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
99287000199	putative trimer interface [polypeptide binding]; other site
99287000200	putative metal binding site [ion binding]; other site
99287000201	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
99287000202	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
99287000203	substrate binding site [chemical binding]; other site
99287000204	oxyanion hole (OAH) forming residues; other site
99287000205	trimer interface [polypeptide binding]; other site
99287000206	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
99287000207	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
99287000208	acyl-activating enzyme (AAE) consensus motif; other site
99287000209	putative AMP binding site [chemical binding]; other site
99287000210	putative active site [active]
99287000211	putative CoA binding site [chemical binding]; other site
99287000212	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
99287000213	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
99287000214	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
99287000215	active site
99287000216	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
99287000217	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
99287000218	Ligand binding site [chemical binding]; other site
99287000219	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
99287000220	Electron transfer flavoprotein domain; Region: ETF; pfam01012
99287000221	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
99287000222	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287000223	putative oxidoreductase FixC; Provisional; Region: PRK10157
99287000224	ferredoxin-like protein FixX; Provisional; Region: PRK15449
99287000225	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287000226	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
99287000227	putative substrate translocation pore; other site
99287000228	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
99287000229	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
99287000230	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
99287000231	Sulfatase; Region: Sulfatase; cl19157
99287000232	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
99287000233	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
99287000234	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
99287000235	TrkA-N domain; Region: TrkA_N; pfam02254
99287000236	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
99287000237	folate binding site [chemical binding]; other site
99287000238	NADP+ binding site [chemical binding]; other site
99287000239	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
99287000240	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
99287000241	active site
99287000242	metal binding site [ion binding]; metal-binding site
99287000243	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
99287000244	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
99287000245	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
99287000246	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
99287000247	SurA N-terminal domain; Region: SurA_N; pfam09312
99287000248	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
99287000249	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
99287000250	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
99287000251	OstA-like protein; Region: OstA; pfam03968
99287000252	Organic solvent tolerance protein; Region: OstA_C; pfam04453
99287000253	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
99287000254	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
99287000255	putative metal binding site [ion binding]; other site
99287000256	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99287000257	HSP70 interaction site [polypeptide binding]; other site
99287000258	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
99287000259	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
99287000260	active site
99287000261	ATP-dependent helicase HepA; Validated; Region: PRK04914
99287000262	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99287000263	ATP binding site [chemical binding]; other site
99287000264	putative Mg++ binding site [ion binding]; other site
99287000265	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287000266	nucleotide binding region [chemical binding]; other site
99287000267	ATP-binding site [chemical binding]; other site
99287000268	RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137
99287000269	DNA polymerase II; Reviewed; Region: PRK05762
99287000270	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
99287000271	active site
99287000272	catalytic site [active]
99287000273	substrate binding site [chemical binding]; other site
99287000274	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
99287000275	active site
99287000276	metal-binding site
99287000277	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
99287000278	putative active site [active]
99287000279	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
99287000280	intersubunit interface [polypeptide binding]; other site
99287000281	active site
99287000282	Zn2+ binding site [ion binding]; other site
99287000283	L-arabinose isomerase; Provisional; Region: PRK02929
99287000284	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
99287000285	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
99287000286	trimer interface [polypeptide binding]; other site
99287000287	putative substrate binding site [chemical binding]; other site
99287000288	putative metal binding site [ion binding]; other site
99287000289	ribulokinase; Provisional; Region: PRK04123
99287000290	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
99287000291	N- and C-terminal domain interface [polypeptide binding]; other site
99287000292	active site
99287000293	MgATP binding site [chemical binding]; other site
99287000294	catalytic site [active]
99287000295	metal binding site [ion binding]; metal-binding site
99287000296	carbohydrate binding site [chemical binding]; other site
99287000297	homodimer interface [polypeptide binding]; other site
99287000298	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
99287000299	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
99287000300	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287000301	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287000302	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
99287000303	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
99287000304	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287000305	Walker A/P-loop; other site
99287000306	ATP binding site [chemical binding]; other site
99287000307	Q-loop/lid; other site
99287000308	ABC transporter signature motif; other site
99287000309	Walker B; other site
99287000310	D-loop; other site
99287000311	H-loop/switch region; other site
99287000312	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
99287000313	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287000314	dimer interface [polypeptide binding]; other site
99287000315	conserved gate region; other site
99287000316	putative PBP binding loops; other site
99287000317	ABC-ATPase subunit interface; other site
99287000318	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287000319	dimer interface [polypeptide binding]; other site
99287000320	conserved gate region; other site
99287000321	putative PBP binding loops; other site
99287000322	ABC-ATPase subunit interface; other site
99287000323	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
99287000324	transcriptional regulator SgrR; Provisional; Region: PRK13626
99287000325	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
99287000326	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
99287000327	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
99287000328	substrate binding site [chemical binding]; other site
99287000329	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
99287000330	substrate binding site [chemical binding]; other site
99287000331	ligand binding site [chemical binding]; other site
99287000332	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
99287000333	2-isopropylmalate synthase; Validated; Region: PRK00915
99287000334	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
99287000335	active site
99287000336	catalytic residues [active]
99287000337	metal binding site [ion binding]; metal-binding site
99287000338	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
99287000339	leu operon leader peptide; Provisional; Region: PRK14744
99287000340	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
99287000341	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287000342	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
99287000343	putative substrate binding pocket [chemical binding]; other site
99287000344	putative dimerization interface [polypeptide binding]; other site
99287000345	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
99287000346	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
99287000347	dimer interface [polypeptide binding]; other site
99287000348	PYR/PP interface [polypeptide binding]; other site
99287000349	TPP binding site [chemical binding]; other site
99287000350	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
99287000351	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
99287000352	TPP-binding site [chemical binding]; other site
99287000353	dimer interface [polypeptide binding]; other site
99287000354	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
99287000355	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
99287000356	putative valine binding site [chemical binding]; other site
99287000357	dimer interface [polypeptide binding]; other site
99287000358	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
99287000359	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
99287000360	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287000361	DNA binding site [nucleotide binding]
99287000362	domain linker motif; other site
99287000363	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
99287000364	dimerization interface [polypeptide binding]; other site
99287000365	ligand binding site [chemical binding]; other site
99287000366	mraZ protein; Region: TIGR00242
99287000367	MraZ protein; Region: MraZ; pfam02381
99287000368	MraZ protein; Region: MraZ; pfam02381
99287000369	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
99287000370	cell division protein FtsL; Provisional; Region: PRK10772
99287000371	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
99287000372	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
99287000373	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
99287000374	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
99287000375	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
99287000376	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99287000377	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
99287000378	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
99287000379	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
99287000380	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99287000381	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
99287000382	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
99287000383	Mg++ binding site [ion binding]; other site
99287000384	putative catalytic motif [active]
99287000385	putative substrate binding site [chemical binding]; other site
99287000386	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
99287000387	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99287000388	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
99287000389	cell division protein FtsW; Provisional; Region: PRK10774
99287000390	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
99287000391	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
99287000392	active site
99287000393	homodimer interface [polypeptide binding]; other site
99287000394	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
99287000395	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
99287000396	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99287000397	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
99287000398	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
99287000399	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
99287000400	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
99287000401	cell division protein FtsQ; Provisional; Region: PRK10775
99287000402	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
99287000403	Cell division protein FtsQ; Region: FtsQ; pfam03799
99287000404	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
99287000405	Cell division protein FtsA; Region: FtsA; pfam14450
99287000406	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99287000407	Cell division protein FtsA; Region: FtsA; pfam14450
99287000408	cell division protein FtsZ; Validated; Region: PRK09330
99287000409	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
99287000410	nucleotide binding site [chemical binding]; other site
99287000411	SulA interaction site; other site
99287000412	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
99287000413	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
99287000414	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
99287000415	SecA regulator SecM; Provisional; Region: PRK02943
99287000416	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
99287000417	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
99287000418	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
99287000419	SEC-C motif; Region: SEC-C; pfam02810
99287000420	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
99287000421	active site
99287000422	8-oxo-dGMP binding site [chemical binding]; other site
99287000423	nudix motif; other site
99287000424	metal binding site [ion binding]; metal-binding site
99287000425	fragment of oxidoreductase
99287000426	DNA gyrase inhibitor; Reviewed; Region: PRK00418
99287000427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
99287000428	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
99287000429	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
99287000430	CoA-binding site [chemical binding]; other site
99287000431	ATP-binding [chemical binding]; other site
99287000432	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
99287000433	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
99287000434	active site
99287000435	type IV pilin biogenesis protein; Provisional; Region: PRK10573
99287000436	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
99287000437	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
99287000438	hypothetical protein; Provisional; Region: PRK10436
99287000439	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
99287000440	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
99287000441	Walker A motif; other site
99287000442	ATP binding site [chemical binding]; other site
99287000443	Walker B motif; other site
99287000444	putative major pilin subunit; Provisional; Region: PRK10574
99287000445	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
99287000446	Pilin (bacterial filament); Region: Pilin; pfam00114
99287000447	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
99287000448	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
99287000449	dimerization interface [polypeptide binding]; other site
99287000450	active site
99287000451	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
99287000452	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
99287000453	amidase catalytic site [active]
99287000454	Zn binding residues [ion binding]; other site
99287000455	substrate binding site [chemical binding]; other site
99287000456	regulatory protein AmpE; Provisional; Region: PRK10987
99287000457	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
99287000458	active site
99287000459	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
99287000460	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287000461	putative substrate translocation pore; other site
99287000462	aromatic amino acid transporter; Provisional; Region: PRK10238
99287000463	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
99287000464	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
99287000465	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287000466	DNA-binding site [nucleotide binding]; DNA binding site
99287000467	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
99287000468	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
99287000469	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
99287000470	dimer interface [polypeptide binding]; other site
99287000471	TPP-binding site [chemical binding]; other site
99287000472	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
99287000473	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
99287000474	E3 interaction surface; other site
99287000475	lipoyl attachment site [posttranslational modification]; other site
99287000476	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
99287000477	E3 interaction surface; other site
99287000478	lipoyl attachment site [posttranslational modification]; other site
99287000479	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
99287000480	E3 interaction surface; other site
99287000481	lipoyl attachment site [posttranslational modification]; other site
99287000482	e3 binding domain; Region: E3_binding; pfam02817
99287000483	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
99287000484	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
99287000485	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287000486	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99287000487	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
99287000488	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
99287000489	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
99287000490	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
99287000491	Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791
99287000492	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
99287000493	substrate binding site [chemical binding]; other site
99287000494	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
99287000495	substrate binding site [chemical binding]; other site
99287000496	ligand binding site [chemical binding]; other site
99287000497	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
99287000498	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
99287000499	active site
99287000500	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3112
99287000501	2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460
99287000502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
99287000503	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
99287000504	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
99287000505	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
99287000506	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287000507	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
99287000508	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287000509	S-adenosylmethionine binding site [chemical binding]; other site
99287000510	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
99287000511	multicopper oxidase; Provisional; Region: PRK10965
99287000512	Cupredoxin superfamily; Region: Cupredoxin; cl19115
99287000513	The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867
99287000514	Domain 1 interface [polypeptide binding]; other site
99287000515	Domain 3 interface [polypeptide binding]; other site
99287000516	The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890
99287000517	Domain 2 interface [polypeptide binding]; other site
99287000518	Domain 1 interface [polypeptide binding]; other site
99287000519	Type 1 (T1) Cu binding site [ion binding]; other site
99287000520	trinuclear Cu binding site [ion binding]; other site
99287000521	Glucose dehydrogenase [Carbohydrate transport and metabolism]; Region: Gcd; COG4993
99287000522	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
99287000523	Trp docking motif [polypeptide binding]; other site
99287000524	putative active site [active]
99287000525	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99287000526	active site
99287000527	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
99287000528	active site clefts [active]
99287000529	zinc binding site [ion binding]; other site
99287000530	dimer interface [polypeptide binding]; other site
99287000531	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
99287000532	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287000533	Walker A/P-loop; other site
99287000534	ATP binding site [chemical binding]; other site
99287000535	Q-loop/lid; other site
99287000536	ABC transporter signature motif; other site
99287000537	Walker B; other site
99287000538	D-loop; other site
99287000539	H-loop/switch region; other site
99287000540	inner membrane transport permease; Provisional; Region: PRK15066
99287000541	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
99287000542	putative fimbrial protein StiH; Provisional; Region: PRK15297
99287000543	fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298
99287000544	PapC N-terminal domain; Region: PapC_N; pfam13954
99287000545	Outer membrane usher protein; Region: Usher; pfam00577
99287000546	PapC C-terminal domain; Region: PapC_C; pfam13953
99287000547	fimbrial chaperone protein StiB; Provisional; Region: PRK15299
99287000548	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287000549	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287000550	fimbrial protein StiA; Provisional; Region: PRK15300
99287000551	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
99287000552	active pocket/dimerization site; other site
99287000553	active site
99287000554	phosphorylation site [posttranslational modification]
99287000555	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
99287000556	putative active site [active]
99287000557	putative metal binding site [ion binding]; other site
99287000558	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
99287000559	tetramerization interface [polypeptide binding]; other site
99287000560	active site
99287000561	Pantoate-beta-alanine ligase; Region: PanC; cd00560
99287000562	active site
99287000563	ATP-binding site [chemical binding]; other site
99287000564	pantoate-binding site; other site
99287000565	HXXH motif; other site
99287000566	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
99287000567	oligomerization interface [polypeptide binding]; other site
99287000568	active site
99287000569	metal binding site [ion binding]; metal-binding site
99287000570	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
99287000571	catalytic center binding site [active]
99287000572	ATP binding site [chemical binding]; other site
99287000573	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
99287000574	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
99287000575	active site
99287000576	NTP binding site [chemical binding]; other site
99287000577	metal binding triad [ion binding]; metal-binding site
99287000578	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
99287000579	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
99287000580	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
99287000581	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
99287000582	active site
99287000583	nucleotide binding site [chemical binding]; other site
99287000584	HIGH motif; other site
99287000585	KMSKS motif; other site
99287000586	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
99287000587	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
99287000588	2'-5' RNA ligase; Provisional; Region: PRK15124
99287000589	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
99287000590	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
99287000591	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
99287000592	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99287000593	ATP binding site [chemical binding]; other site
99287000594	putative Mg++ binding site [ion binding]; other site
99287000595	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287000596	nucleotide binding region [chemical binding]; other site
99287000597	ATP-binding site [chemical binding]; other site
99287000598	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
99287000599	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
99287000600	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
99287000601	Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812
99287000602	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
99287000603	Transglycosylase; Region: Transgly; pfam00912
99287000604	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
99287000605	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
99287000606	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99287000607	N-terminal plug; other site
99287000608	ligand-binding site [chemical binding]; other site
99287000609	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
99287000610	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
99287000611	Walker A/P-loop; other site
99287000612	ATP binding site [chemical binding]; other site
99287000613	Q-loop/lid; other site
99287000614	ABC transporter signature motif; other site
99287000615	Walker B; other site
99287000616	D-loop; other site
99287000617	H-loop/switch region; other site
99287000618	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
99287000619	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
99287000620	siderophore binding site; other site
99287000621	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
99287000622	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
99287000623	ABC-ATPase subunit  interface; other site
99287000624	dimer interface [polypeptide binding]; other site
99287000625	putative PBP binding regions; other site
99287000626	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
99287000627	ABC-ATPase subunit  interface; other site
99287000628	dimer interface [polypeptide binding]; other site
99287000629	putative PBP binding regions; other site
99287000630	putative fimbrial subunit StfA; Provisional; Region: PRK15283
99287000631	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
99287000632	PapC N-terminal domain; Region: PapC_N; pfam13954
99287000633	Outer membrane usher protein; Region: Usher; pfam00577
99287000634	PapC C-terminal domain; Region: PapC_C; pfam13953
99287000635	putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285
99287000636	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287000637	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287000638	putative minor fimbrial subunit StfE; Provisional; Region: PRK15286
99287000639	putative minor fimbrial subunit StfF; Provisional; Region: PRK15287
99287000640	putative minor fimbrial subunit StfG; Provisional; Region: PRK15288
99287000641	Protein of unknown function (DUF2544); Region: DUF2544; pfam11245
99287000642	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
99287000643	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
99287000644	inhibitor-cofactor binding pocket; inhibition site
99287000645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287000646	catalytic residue [active]
99287000647	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
99287000648	Cl- selectivity filter; other site
99287000649	Cl- binding residues [ion binding]; other site
99287000650	pore gating glutamate residue; other site
99287000651	dimer interface [polypeptide binding]; other site
99287000652	H+/Cl- coupling transport residue; other site
99287000653	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
99287000654	hypothetical protein; Provisional; Region: PRK10578
99287000655	UPF0126 domain; Region: UPF0126; pfam03458
99287000656	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
99287000657	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
99287000658	cobalamin binding residues [chemical binding]; other site
99287000659	putative BtuC binding residues; other site
99287000660	dimer interface [polypeptide binding]; other site
99287000661	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
99287000662	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
99287000663	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
99287000664	Zn2+ binding site [ion binding]; other site
99287000665	Mg2+ binding site [ion binding]; other site
99287000666	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
99287000667	serine endoprotease; Provisional; Region: PRK10942
99287000668	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99287000669	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
99287000670	protein binding site [polypeptide binding]; other site
99287000671	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
99287000672	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
99287000673	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
99287000674	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
99287000675	hypothetical protein; Provisional; Region: PRK13677
99287000676	shikimate transporter; Provisional; Region: PRK09952
99287000677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287000678	putative substrate translocation pore; other site
99287000679	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
99287000680	Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805
99287000681	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
99287000682	trimer interface [polypeptide binding]; other site
99287000683	active site
99287000684	substrate binding site [chemical binding]; other site
99287000685	CoA binding site [chemical binding]; other site
99287000686	PII uridylyl-transferase; Provisional; Region: PRK05007
99287000687	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
99287000688	metal binding triad; other site
99287000689	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
99287000690	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
99287000691	Zn2+ binding site [ion binding]; other site
99287000692	Mg2+ binding site [ion binding]; other site
99287000693	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
99287000694	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
99287000695	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
99287000696	active site
99287000697	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
99287000698	rRNA interaction site [nucleotide binding]; other site
99287000699	S8 interaction site; other site
99287000700	putative laminin-1 binding site; other site
99287000701	elongation factor Ts; Provisional; Region: tsf; PRK09377
99287000702	UBA/TS-N domain; Region: UBA; pfam00627
99287000703	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
99287000704	putative nucleotide binding site [chemical binding]; other site
99287000705	uridine monophosphate binding site [chemical binding]; other site
99287000706	homohexameric interface [polypeptide binding]; other site
99287000707	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
99287000708	hinge region; other site
99287000709	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
99287000710	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
99287000711	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
99287000712	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
99287000713	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
99287000714	active site
99287000715	dimer interface [polypeptide binding]; other site
99287000716	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
99287000717	zinc metallopeptidase RseP; Provisional; Region: PRK10779
99287000718	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
99287000719	active site
99287000720	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
99287000721	protein binding site [polypeptide binding]; other site
99287000722	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
99287000723	protein binding site [polypeptide binding]; other site
99287000724	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
99287000725	putative substrate binding region [chemical binding]; other site
99287000726	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
99287000727	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
99287000728	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
99287000729	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
99287000730	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
99287000731	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
99287000732	Surface antigen; Region: Bac_surface_Ag; pfam01103
99287000733	periplasmic chaperone; Provisional; Region: PRK10780
99287000734	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
99287000735	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
99287000736	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
99287000737	trimer interface [polypeptide binding]; other site
99287000738	active site
99287000739	UDP-GlcNAc binding site [chemical binding]; other site
99287000740	lipid binding site [chemical binding]; lipid-binding site
99287000741	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
99287000742	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
99287000743	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
99287000744	active site
99287000745	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
99287000746	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
99287000747	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
99287000748	RNA/DNA hybrid binding site [nucleotide binding]; other site
99287000749	active site
99287000750	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
99287000751	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
99287000752	putative active site [active]
99287000753	putative PHP Thumb interface [polypeptide binding]; other site
99287000754	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
99287000755	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
99287000756	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
99287000757	generic binding surface II; other site
99287000758	generic binding surface I; other site
99287000759	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
99287000760	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
99287000761	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
99287000762	putative sugar binding site [chemical binding]; other site
99287000763	catalytic residues [active]
99287000764	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
99287000765	lysine decarboxylase LdcC; Provisional; Region: PRK15399
99287000766	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
99287000767	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
99287000768	homodimer interface [polypeptide binding]; other site
99287000769	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287000770	catalytic residue [active]
99287000771	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
99287000772	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
99287000773	putative metal binding site [ion binding]; other site
99287000774	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
99287000775	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
99287000776	Ligand Binding Site [chemical binding]; other site
99287000777	TilS substrate binding domain; Region: TilS; pfam09179
99287000778	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
99287000779	Rho-binding antiterminator; Provisional; Region: PRK11625
99287000780	hypothetical protein; Provisional; Region: PRK04964
99287000781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
99287000782	hypothetical protein; Provisional; Region: PRK09256
99287000783	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
99287000784	pseudogene; frameshift relative to Escherichia coli cutF (SW:CUTF_ECOLI); copper homeostasis protein
99287000785	prolyl-tRNA synthetase; Provisional; Region: PRK09194
99287000786	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
99287000787	dimer interface [polypeptide binding]; other site
99287000788	motif 1; other site
99287000789	active site
99287000790	motif 2; other site
99287000791	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
99287000792	putative deacylase active site [active]
99287000793	motif 3; other site
99287000794	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
99287000795	anticodon binding site; other site
99287000796	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
99287000797	homodimer interaction site [polypeptide binding]; other site
99287000798	cofactor binding site; other site
99287000799	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
99287000800	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
99287000801	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287000802	dimer interface [polypeptide binding]; other site
99287000803	conserved gate region; other site
99287000804	putative PBP binding loops; other site
99287000805	ABC-ATPase subunit interface; other site
99287000806	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
99287000807	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
99287000808	Walker A/P-loop; other site
99287000809	ATP binding site [chemical binding]; other site
99287000810	Q-loop/lid; other site
99287000811	ABC transporter signature motif; other site
99287000812	Walker B; other site
99287000813	D-loop; other site
99287000814	H-loop/switch region; other site
99287000815	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
99287000816	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
99287000817	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287000818	active site
99287000819	motif I; other site
99287000820	motif II; other site
99287000821	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99287000822	active site
99287000823	catalytic tetrad [active]
99287000824	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287000825	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287000826	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
99287000827	putative effector binding pocket; other site
99287000828	dimerization interface [polypeptide binding]; other site
99287000829	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
99287000830	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287000831	putative substrate translocation pore; other site
99287000832	hypothetical protein; Provisional; Region: PRK05421
99287000833	putative catalytic site [active]
99287000834	putative metal binding site [ion binding]; other site
99287000835	putative phosphate binding site [ion binding]; other site
99287000836	putative catalytic site [active]
99287000837	putative phosphate binding site [ion binding]; other site
99287000838	putative metal binding site [ion binding]; other site
99287000839	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287000840	S-adenosylmethionine binding site [chemical binding]; other site
99287000841	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
99287000842	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
99287000843	N-acetyl-D-glucosamine binding site [chemical binding]; other site
99287000844	catalytic residue [active]
99287000845	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
99287000846	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
99287000847	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
99287000848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287000849	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
99287000850	RNA/DNA hybrid binding site [nucleotide binding]; other site
99287000851	active site
99287000852	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
99287000853	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
99287000854	active site
99287000855	catalytic site [active]
99287000856	substrate binding site [chemical binding]; other site
99287000857	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
99287000858	ImpA-related N-terminal; Region: ImpA-rel_N; cl19907
99287000859	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
99287000860	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
99287000861	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
99287000862	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
99287000863	ImpE protein; Region: ImpE; pfam07024
99287000864	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
99287000865	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287000866	Walker A motif; other site
99287000867	ATP binding site [chemical binding]; other site
99287000868	Walker B motif; other site
99287000869	arginine finger; other site
99287000870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287000871	Walker A motif; other site
99287000872	ATP binding site [chemical binding]; other site
99287000873	Walker B motif; other site
99287000874	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
99287000875	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
99287000876	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
99287000877	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
99287000878	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
99287000879	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
99287000880	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
99287000881	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
99287000882	hypothetical protein; Provisional; Region: PRK08126
99287000883	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
99287000884	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
99287000885	ligand binding site [chemical binding]; other site
99287000886	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
99287000887	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
99287000888	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
99287000889	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
99287000890	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
99287000891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893
99287000892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
99287000893	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
99287000894	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
99287000895	Uncharacterized conserved protein [Function unknown]; Region: COG5435
99287000896	PAAR motif; Region: PAAR_motif; pfam05488
99287000897	RHS Repeat; Region: RHS_repeat; pfam05593
99287000898	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
99287000899	RHS Repeat; Region: RHS_repeat; pfam05593
99287000900	RHS Repeat; Region: RHS_repeat; pfam05593
99287000901	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
99287000902	RHS protein; Region: RHS; pfam03527
99287000903	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
99287000904	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
99287000905	RHS protein; Region: RHS; pfam03527
99287000906	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
99287000907	Putative toxin 62; Region: Toxin_62; pfam15540
99287000908	Immunity protein 14; Region: Imm14; pfam15428
99287000909	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446
99287000910	integrase core domain
99287000911	Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221
99287000912	pili assembly chaperone protein SafB; Provisional; Region: PRK15224
99287000913	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287000914	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287000915	pilin outer membrane usher protein SafC; Provisional; Region: PRK15223
99287000916	PapC N-terminal domain; Region: PapC_N; pfam13954
99287000917	Outer membrane usher protein; Region: Usher; pfam00577
99287000918	PapC C-terminal domain; Region: PapC_C; pfam13953
99287000919	putative pilin structural protein SafD; Provisional; Region: PRK15222
99287000920	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
99287000921	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
99287000922	putative active site [active]
99287000923	putative metal binding site [ion binding]; other site
99287000924	PerC transcriptional activator; Region: PerC; pfam06069
99287000925	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287000926	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287000927	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287000928	dimerization interface [polypeptide binding]; other site
99287000929	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
99287000930	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
99287000931	dimer interface [polypeptide binding]; other site
99287000932	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
99287000933	putative active site [active]
99287000934	catalytic triad [active]
99287000935	dimer interface [polypeptide binding]; other site
99287000936	multimer interface [polypeptide binding]; other site
99287000937	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
99287000938	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
99287000939	active site
99287000940	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
99287000941	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
99287000942	dimer interface [polypeptide binding]; other site
99287000943	active site
99287000944	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
99287000945	putative active site [active]
99287000946	Glutamine amidotransferases class-II; Region: GATase_2; pfam00310
99287000947	putative dimer interface [polypeptide binding]; other site
99287000948	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
99287000949	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
99287000950	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
99287000951	active site
99287000952	DNA polymerase IV; Validated; Region: PRK02406
99287000953	DNA binding site [nucleotide binding]
99287000954	Uncharacterized conserved protein [Function unknown]; Region: RtcB; cl17455
99287000955	tRNA-splicing ligase RtcB; Region: RtcB; pfam01139
99287000956	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
99287000957	putative peptide chain release factor H; Region: release_prfH; TIGR03072
99287000958	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
99287000959	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
99287000960	metal binding site [ion binding]; metal-binding site
99287000961	dimer interface [polypeptide binding]; other site
99287000962	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99287000963	active site
99287000964	Putative lysophospholipase; Region: Hydrolase_4; cl19140
99287000965	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
99287000966	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
99287000967	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
99287000968	trimer interface [polypeptide binding]; other site
99287000969	eyelet of channel; other site
99287000970	gamma-glutamyl kinase; Provisional; Region: PRK05429
99287000971	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
99287000972	nucleotide binding site [chemical binding]; other site
99287000973	homotetrameric interface [polypeptide binding]; other site
99287000974	putative phosphate binding site [ion binding]; other site
99287000975	putative allosteric binding site; other site
99287000976	PUA domain; Region: PUA; pfam01472
99287000977	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
99287000978	putative catalytic cysteine [active]
99287000979	HTH-like domain; Region: HTH_21; pfam13276
99287000980	Integrase core domain; Region: rve; pfam00665
99287000981	Integrase core domain; Region: rve_3; pfam13683
99287000982	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
99287000983	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
99287000984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287000985	putative substrate translocation pore; other site
99287000986	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
99287000987	substrate binding site [chemical binding]; other site
99287000988	ligand binding site [chemical binding]; other site
99287000989	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
99287000990	substrate binding site [chemical binding]; other site
99287000991	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
99287000992	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
99287000993	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
99287000994	Putative lysophospholipase; Region: Hydrolase_4; cl19140
99287000995	transcriptional activator TtdR; Provisional; Region: PRK09801
99287000996	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287000997	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
99287000998	putative effector binding pocket; other site
99287000999	putative dimerization interface [polypeptide binding]; other site
99287001000	YjzC-like protein; Region: YjzC; pfam14168
99287001001	fimbrial assembly chaperone StbE; Provisional; Region: PRK15246
99287001002	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287001003	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287001004	putative fimbrial usher protein StbD; Provisional; Region: PRK15247
99287001005	fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248
99287001006	PapC N-terminal domain; Region: PapC_N; pfam13954
99287001007	Outer membrane usher protein; Region: Usher; pfam00577
99287001008	PapC C-terminal domain; Region: PapC_C; pfam13953
99287001009	fimbrial chaperone protein StbB; Provisional; Region: PRK15249
99287001010	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287001011	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287001012	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
99287001013	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
99287001014	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
99287001015	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
99287001016	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287001017	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99287001018	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
99287001019	DNA binding site [nucleotide binding]
99287001020	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
99287001021	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
99287001022	DNA binding residues [nucleotide binding]
99287001023	dimerization interface [polypeptide binding]; other site
99287001024	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
99287001025	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
99287001026	Outer membrane efflux protein; Region: OEP; pfam02321
99287001027	Outer membrane efflux protein; Region: OEP; pfam02321
99287001028	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
99287001029	MMPL family; Region: MMPL; cl14618
99287001030	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
99287001031	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99287001032	HlyD family secretion protein; Region: HlyD_3; pfam13437
99287001033	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
99287001034	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
99287001035	metal-binding site [ion binding]
99287001036	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99287001037	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287001038	motif II; other site
99287001039	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
99287001040	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
99287001041	DNA binding residues [nucleotide binding]
99287001042	dimer interface [polypeptide binding]; other site
99287001043	copper binding site [ion binding]; other site
99287001044	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
99287001045	metal-binding site [ion binding]
99287001046	putative sialic acid transporter; Region: 2A0112; TIGR00891
99287001047	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287001048	putative substrate translocation pore; other site
99287001049	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
99287001050	DNA methylase; Region: N6_N4_Mtase; cl17433
99287001051	DNA methylase; Region: N6_N4_Mtase; pfam01555
99287001052	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
99287001053	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99287001054	ATP binding site [chemical binding]; other site
99287001055	VRR-NUC domain; Region: VRR_NUC; pfam08774
99287001056	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
99287001057	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
99287001058	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
99287001059	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287001060	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99287001061	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
99287001062	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99287001063	N-terminal plug; other site
99287001064	ligand-binding site [chemical binding]; other site
99287001065	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
99287001066	hypothetical protein; Provisional; Region: PRK09929
99287001067	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
99287001068	Propionate catabolism activator; Region: PrpR_N; pfam06506
99287001069	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287001070	Walker A motif; other site
99287001071	ATP binding site [chemical binding]; other site
99287001072	Walker B motif; other site
99287001073	arginine finger; other site
99287001074	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
99287001075	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
99287001076	tetramer interface [polypeptide binding]; other site
99287001077	active site
99287001078	Mg2+/Mn2+ binding site [ion binding]; other site
99287001079	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
99287001080	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
99287001081	dimer interface [polypeptide binding]; other site
99287001082	active site
99287001083	citrylCoA binding site [chemical binding]; other site
99287001084	oxalacetate/citrate binding site [chemical binding]; other site
99287001085	coenzyme A binding site [chemical binding]; other site
99287001086	catalytic triad [active]
99287001087	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
99287001088	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
99287001089	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
99287001090	acyl-activating enzyme (AAE) consensus motif; other site
99287001091	AMP binding site [chemical binding]; other site
99287001092	active site
99287001093	CoA binding site [chemical binding]; other site
99287001094	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
99287001095	dimer interface [polypeptide binding]; other site
99287001096	active site
99287001097	Schiff base residues; other site
99287001098	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
99287001099	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
99287001100	Autotransporter beta-domain; Region: Autotransporter; pfam03797
99287001101	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
99287001102	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99287001103	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
99287001104	ligand binding site [chemical binding]; other site
99287001105	flexible hinge region; other site
99287001106	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
99287001107	microcin B17 transporter; Reviewed; Region: PRK11098
99287001108	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
99287001109	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
99287001110	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
99287001111	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
99287001112	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
99287001113	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
99287001114	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
99287001115	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
99287001116	drug efflux system protein MdtG; Provisional; Region: PRK09874
99287001117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287001118	putative substrate translocation pore; other site
99287001119	anti-RssB factor; Provisional; Region: PRK10244
99287001120	hypothetical protein; Provisional; Region: PRK11505
99287001121	psiF repeat; Region: PsiF_repeat; pfam07769
99287001122	psiF repeat; Region: PsiF_repeat; pfam07769
99287001123	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
99287001124	MASE2 domain; Region: MASE2; pfam05230
99287001125	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99287001126	metal binding site [ion binding]; metal-binding site
99287001127	active site
99287001128	I-site; other site
99287001129	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
99287001130	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
99287001131	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
99287001132	hypothetical protein; Validated; Region: PRK00124
99287001133	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
99287001134	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
99287001135	ADP binding site [chemical binding]; other site
99287001136	magnesium binding site [ion binding]; other site
99287001137	putative shikimate binding site; other site
99287001138	hypothetical protein; Provisional; Region: PRK10380
99287001139	hypothetical protein; Provisional; Region: PRK10481
99287001140	hypothetical protein; Provisional; Region: PRK10579
99287001141	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
99287001142	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
99287001143	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99287001144	nucleotide binding site [chemical binding]; other site
99287001145	MFS transport protein AraJ; Provisional; Region: PRK10091
99287001146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287001147	putative substrate translocation pore; other site
99287001148	exonuclease subunit SbcC; Provisional; Region: PRK10246
99287001149	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287001150	Walker A/P-loop; other site
99287001151	ATP binding site [chemical binding]; other site
99287001152	Q-loop/lid; other site
99287001153	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287001154	ABC transporter signature motif; other site
99287001155	Walker B; other site
99287001156	D-loop; other site
99287001157	H-loop/switch region; other site
99287001158	exonuclease subunit SbcD; Provisional; Region: PRK10966
99287001159	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
99287001160	active site
99287001161	metal binding site [ion binding]; metal-binding site
99287001162	DNA binding site [nucleotide binding]
99287001163	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
99287001164	transcriptional regulator PhoB; Provisional; Region: PRK10161
99287001165	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287001166	active site
99287001167	phosphorylation site [posttranslational modification]
99287001168	intermolecular recognition site; other site
99287001169	dimerization interface [polypeptide binding]; other site
99287001170	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287001171	DNA binding site [nucleotide binding]
99287001172	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
99287001173	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
99287001174	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99287001175	putative active site [active]
99287001176	heme pocket [chemical binding]; other site
99287001177	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287001178	dimer interface [polypeptide binding]; other site
99287001179	phosphorylation site [posttranslational modification]
99287001180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287001181	ATP binding site [chemical binding]; other site
99287001182	Mg2+ binding site [ion binding]; other site
99287001183	G-X-G motif; other site
99287001184	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
99287001185	putative proline-specific permease; Provisional; Region: proY; PRK10580
99287001186	Spore germination protein; Region: Spore_permease; cl17796
99287001187	maltodextrin glucosidase; Provisional; Region: PRK10785
99287001188	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
99287001189	homodimer interface [polypeptide binding]; other site
99287001190	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
99287001191	active site
99287001192	homodimer interface [polypeptide binding]; other site
99287001193	catalytic site [active]
99287001194	peroxidase; Provisional; Region: PRK15000
99287001195	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
99287001196	dimer interface [polypeptide binding]; other site
99287001197	decamer (pentamer of dimers) interface [polypeptide binding]; other site
99287001198	catalytic triad [active]
99287001199	peroxidatic and resolving cysteines [active]
99287001200	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
99287001201	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
99287001202	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
99287001203	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
99287001204	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
99287001205	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
99287001206	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
99287001207	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
99287001208	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
99287001209	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
99287001210	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
99287001211	Protein export membrane protein; Region: SecD_SecF; pfam02355
99287001212	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
99287001213	Predicted transcriptional regulator [Transcription]; Region: COG2378
99287001214	HTH domain; Region: HTH_11; pfam08279
99287001215	WYL domain; Region: WYL; pfam13280
99287001216	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
99287001217	active site
99287001218	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
99287001219	hypothetical protein; Provisional; Region: PRK11530
99287001220	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
99287001221	ATP cone domain; Region: ATP-cone; pfam03477
99287001222	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
99287001223	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
99287001224	catalytic motif [active]
99287001225	Zn binding site [ion binding]; other site
99287001226	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
99287001227	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
99287001228	homopentamer interface [polypeptide binding]; other site
99287001229	active site
99287001230	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
99287001231	thiamine monophosphate kinase; Provisional; Region: PRK05731
99287001232	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
99287001233	ATP binding site [chemical binding]; other site
99287001234	dimerization interface [polypeptide binding]; other site
99287001235	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
99287001236	tetramer interfaces [polypeptide binding]; other site
99287001237	binuclear metal-binding site [ion binding]; other site
99287001238	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99287001239	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
99287001240	active site
99287001241	catalytic tetrad [active]
99287001242	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
99287001243	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
99287001244	TPP-binding site; other site
99287001245	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
99287001246	PYR/PP interface [polypeptide binding]; other site
99287001247	dimer interface [polypeptide binding]; other site
99287001248	TPP binding site [chemical binding]; other site
99287001249	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
99287001250	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
99287001251	substrate binding pocket [chemical binding]; other site
99287001252	chain length determination region; other site
99287001253	active site lid residues [active]
99287001254	substrate-Mg2+ binding site; other site
99287001255	catalytic residues [active]
99287001256	aspartate-rich region 1; other site
99287001257	aspartate-rich region 2; other site
99287001258	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
99287001259	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
99287001260	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
99287001261	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
99287001262	Ligand Binding Site [chemical binding]; other site
99287001263	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
99287001264	active site residue [active]
99287001265	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
99287001266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287001267	dimer interface [polypeptide binding]; other site
99287001268	conserved gate region; other site
99287001269	putative PBP binding loops; other site
99287001270	ABC-ATPase subunit interface; other site
99287001271	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
99287001272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287001273	dimer interface [polypeptide binding]; other site
99287001274	conserved gate region; other site
99287001275	putative PBP binding loops; other site
99287001276	ABC-ATPase subunit interface; other site
99287001277	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
99287001278	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287001279	Walker A/P-loop; other site
99287001280	ATP binding site [chemical binding]; other site
99287001281	Q-loop/lid; other site
99287001282	ABC transporter signature motif; other site
99287001283	Walker B; other site
99287001284	D-loop; other site
99287001285	H-loop/switch region; other site
99287001286	TOBE domain; Region: TOBE_2; pfam08402
99287001287	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
99287001288	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
99287001289	transcriptional regulator protein; Region: phnR; TIGR03337
99287001290	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287001291	DNA-binding site [nucleotide binding]; DNA binding site
99287001292	UTRA domain; Region: UTRA; pfam07702
99287001293	2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326
99287001294	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99287001295	catalytic residue [active]
99287001296	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
99287001297	phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422
99287001298	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287001299	motif II; other site
99287001300	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
99287001301	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
99287001302	conserved cys residue [active]
99287001303	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
99287001304	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
99287001305	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
99287001306	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
99287001307	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287001308	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99287001309	putative substrate translocation pore; other site
99287001310	Sel1-like repeats; Region: SEL1; smart00671
99287001311	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
99287001312	Sel1 repeat; Region: Sel1; pfam08238
99287001313	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
99287001314	Sel1-like repeats; Region: SEL1; smart00671
99287001315	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
99287001316	Sel1 repeat; Region: Sel1; pfam08238
99287001317	Sel1-like repeats; Region: SEL1; smart00671
99287001318	Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957
99287001319	putative active site [active]
99287001320	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
99287001321	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
99287001322	Subunit I/III interface [polypeptide binding]; other site
99287001323	Subunit III/IV interface [polypeptide binding]; other site
99287001324	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
99287001325	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
99287001326	D-pathway; other site
99287001327	Putative ubiquinol binding site [chemical binding]; other site
99287001328	Low-spin heme (heme b) binding site [chemical binding]; other site
99287001329	Putative water exit pathway; other site
99287001330	Binuclear center (heme o3/CuB) [ion binding]; other site
99287001331	K-pathway; other site
99287001332	Putative proton exit pathway; other site
99287001333	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
99287001334	The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212
99287001335	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
99287001336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287001337	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99287001338	putative substrate translocation pore; other site
99287001339	hypothetical protein; Provisional; Region: PRK11627
99287001340	transcriptional regulator BolA; Provisional; Region: PRK11628
99287001341	trigger factor; Provisional; Region: tig; PRK01490
99287001342	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
99287001343	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
99287001344	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
99287001345	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
99287001346	oligomer interface [polypeptide binding]; other site
99287001347	active site residues [active]
99287001348	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
99287001349	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
99287001350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287001351	Walker A motif; other site
99287001352	ATP binding site [chemical binding]; other site
99287001353	Walker B motif; other site
99287001354	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
99287001355	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
99287001356	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
99287001357	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287001358	Walker A motif; other site
99287001359	ATP binding site [chemical binding]; other site
99287001360	Walker B motif; other site
99287001361	arginine finger; other site
99287001362	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
99287001363	histone-like DNA-binding protein HU; Region: HU; cd13831
99287001364	dimer interface [polypeptide binding]; other site
99287001365	DNA binding site [nucleotide binding]
99287001366	periplasmic folding chaperone; Provisional; Region: PRK10788
99287001367	SurA N-terminal domain; Region: SurA_N_3; cl07813
99287001368	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
99287001369	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
99287001370	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
99287001371	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
99287001372	active site
99287001373	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
99287001374	Ligand Binding Site [chemical binding]; other site
99287001375	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
99287001376	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
99287001377	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
99287001378	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
99287001379	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
99287001380	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287001381	active site
99287001382	motif I; other site
99287001383	motif II; other site
99287001384	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
99287001385	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99287001386	catalytic residue [active]
99287001387	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
99287001388	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99287001389	putative DNA binding site [nucleotide binding]; other site
99287001390	putative Zn2+ binding site [ion binding]; other site
99287001391	AsnC family; Region: AsnC_trans_reg; pfam01037
99287001392	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99287001393	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
99287001394	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287001395	Walker A/P-loop; other site
99287001396	ATP binding site [chemical binding]; other site
99287001397	Q-loop/lid; other site
99287001398	ABC transporter signature motif; other site
99287001399	Walker B; other site
99287001400	D-loop; other site
99287001401	H-loop/switch region; other site
99287001402	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
99287001403	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99287001404	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287001405	Walker A/P-loop; other site
99287001406	ATP binding site [chemical binding]; other site
99287001407	Q-loop/lid; other site
99287001408	ABC transporter signature motif; other site
99287001409	Walker B; other site
99287001410	D-loop; other site
99287001411	H-loop/switch region; other site
99287001412	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
99287001413	ammonium transporter; Provisional; Region: PRK10666
99287001414	acyl-CoA thioesterase II; Provisional; Region: PRK10526
99287001415	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
99287001416	active site
99287001417	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
99287001418	catalytic triad [active]
99287001419	dimer interface [polypeptide binding]; other site
99287001420	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
99287001421	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
99287001422	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
99287001423	DNA binding site [nucleotide binding]
99287001424	active site
99287001425	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
99287001426	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
99287001427	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287001428	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
99287001429	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
99287001430	Inner membrane protein YlaC; Region: YlaC; pfam10777
99287001431	maltose O-acetyltransferase; Provisional; Region: PRK10092
99287001432	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
99287001433	active site
99287001434	substrate binding site [chemical binding]; other site
99287001435	trimer interface [polypeptide binding]; other site
99287001436	CoA binding site [chemical binding]; other site
99287001437	gene expression modulator; Provisional; Region: PRK10945
99287001438	Hha toxicity attenuator; Provisional; Region: PRK10667
99287001439	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
99287001440	MMPL family; Region: MMPL; cl14618
99287001441	MMPL family; Region: MMPL; cl14618
99287001442	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
99287001443	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
99287001444	HlyD family secretion protein; Region: HlyD_3; pfam13437
99287001445	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
99287001446	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287001447	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
99287001448	hypothetical protein; Provisional; Region: PRK11281
99287001449	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
99287001450	Mechanosensitive ion channel; Region: MS_channel; pfam00924
99287001451	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99287001452	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
99287001453	hypothetical protein; Provisional; Region: PRK11038
99287001454	primosomal replication protein N''; Provisional; Region: PRK10093
99287001455	hypothetical protein; Provisional; Region: PRK10527
99287001456	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99287001457	active site
99287001458	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
99287001459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287001460	Walker A motif; other site
99287001461	ATP binding site [chemical binding]; other site
99287001462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
99287001463	Walker B motif; other site
99287001464	arginine finger; other site
99287001465	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
99287001466	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
99287001467	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
99287001468	hypothetical protein; Validated; Region: PRK00153
99287001469	recombination protein RecR; Reviewed; Region: recR; PRK00076
99287001470	RecR protein; Region: RecR; pfam02132
99287001471	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
99287001472	putative active site [active]
99287001473	putative metal-binding site [ion binding]; other site
99287001474	tetramer interface [polypeptide binding]; other site
99287001475	heat shock protein 90; Provisional; Region: PRK05218
99287001476	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287001477	ATP binding site [chemical binding]; other site
99287001478	Mg2+ binding site [ion binding]; other site
99287001479	G-X-G motif; other site
99287001480	Hsp90 protein; Region: HSP90; pfam00183
99287001481	adenylate kinase; Reviewed; Region: adk; PRK00279
99287001482	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
99287001483	AMP-binding site [chemical binding]; other site
99287001484	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
99287001485	ferrochelatase; Reviewed; Region: hemH; PRK00035
99287001486	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
99287001487	C-terminal domain interface [polypeptide binding]; other site
99287001488	active site
99287001489	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
99287001490	active site
99287001491	N-terminal domain interface [polypeptide binding]; other site
99287001492	acetyl esterase; Provisional; Region: PRK10162
99287001493	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
99287001494	inosine/guanosine kinase; Provisional; Region: PRK15074
99287001495	substrate binding site [chemical binding]; other site
99287001496	ATP binding site [chemical binding]; other site
99287001497	putative cation:proton antiport protein; Provisional; Region: PRK10669
99287001498	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
99287001499	TrkA-N domain; Region: TrkA_N; pfam02254
99287001500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287001501	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99287001502	putative substrate translocation pore; other site
99287001503	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
99287001504	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
99287001505	active site
99287001506	metal binding site [ion binding]; metal-binding site
99287001507	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
99287001508	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
99287001509	putative deacylase active site [active]
99287001510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
99287001511	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
99287001512	copper exporting ATPase; Provisional; Region: copA; PRK10671
99287001513	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
99287001514	metal-binding site [ion binding]
99287001515	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
99287001516	metal-binding site [ion binding]
99287001517	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99287001518	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287001519	motif II; other site
99287001520	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
99287001521	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
99287001522	DNA binding residues [nucleotide binding]
99287001523	dimer interface [polypeptide binding]; other site
99287001524	copper binding site [ion binding]; other site
99287001525	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
99287001526	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
99287001527	Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829
99287001528	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
99287001529	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
99287001530	Walker A/P-loop; other site
99287001531	ATP binding site [chemical binding]; other site
99287001532	Q-loop/lid; other site
99287001533	ABC transporter signature motif; other site
99287001534	Walker B; other site
99287001535	D-loop; other site
99287001536	H-loop/switch region; other site
99287001537	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
99287001538	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
99287001539	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
99287001540	Tetratricopeptide repeat; Region: TPR_20; pfam14561
99287001541	short chain dehydrogenase; Validated; Region: PRK06182
99287001542	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
99287001543	NADP binding site [chemical binding]; other site
99287001544	active site
99287001545	steroid binding site; other site
99287001546	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
99287001547	active site
99287001548	catalytic triad [active]
99287001549	oxyanion hole [active]
99287001550	switch loop; other site
99287001551	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
99287001552	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
99287001553	Walker A/P-loop; other site
99287001554	ATP binding site [chemical binding]; other site
99287001555	Q-loop/lid; other site
99287001556	ABC transporter signature motif; other site
99287001557	Walker B; other site
99287001558	D-loop; other site
99287001559	H-loop/switch region; other site
99287001560	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
99287001561	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99287001562	FtsX-like permease family; Region: FtsX; pfam02687
99287001563	FtsX-like permease family; Region: FtsX; pfam02687
99287001564	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
99287001565	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
99287001566	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
99287001567	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
99287001568	Walker A/P-loop; other site
99287001569	ATP binding site [chemical binding]; other site
99287001570	Q-loop/lid; other site
99287001571	ABC transporter signature motif; other site
99287001572	Walker B; other site
99287001573	D-loop; other site
99287001574	H-loop/switch region; other site
99287001575	NIL domain; Region: NIL; pfam09383
99287001576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287001577	dimer interface [polypeptide binding]; other site
99287001578	conserved gate region; other site
99287001579	putative PBP binding loops; other site
99287001580	ABC-ATPase subunit interface; other site
99287001581	Predicted ATPase [General function prediction only]; Region: COG2603
99287001582	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
99287001583	active site residue [active]
99287001584	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
99287001585	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287001586	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287001587	dimerization interface [polypeptide binding]; other site
99287001588	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
99287001589	DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163
99287001590	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
99287001591	Bacterial transcriptional regulator; Region: IclR; pfam01614
99287001592	glyoxylate carboligase; Provisional; Region: PRK11269
99287001593	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
99287001594	PYR/PP interface [polypeptide binding]; other site
99287001595	dimer interface [polypeptide binding]; other site
99287001596	TPP binding site [chemical binding]; other site
99287001597	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
99287001598	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
99287001599	TPP-binding site [chemical binding]; other site
99287001600	hydroxypyruvate isomerase; Provisional; Region: PRK09997
99287001601	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
99287001602	tartronate semialdehyde reductase; Provisional; Region: PRK15059
99287001603	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
99287001604	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
99287001605	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287001606	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99287001607	putative substrate translocation pore; other site
99287001608	nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323
99287001609	substrate binding site [chemical binding]; other site
99287001610	Na binding site [ion binding]; other site
99287001611	allantoinase; Provisional; Region: PRK08044
99287001612	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
99287001613	active site
99287001614	putative uracil/xanthine transporter; Provisional; Region: PRK11412
99287001615	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
99287001616	glycerate kinase II; Provisional; Region: PRK09932
99287001617	Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257
99287001618	Mif2/CENP-C like; Region: CENP-C_C; pfam11699
99287001619	Cupin domain; Region: Cupin_2; cl17218
99287001620	allantoate amidohydrolase; Region: AllC; TIGR03176
99287001621	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
99287001622	active site
99287001623	metal binding site [ion binding]; metal-binding site
99287001624	dimer interface [polypeptide binding]; other site
99287001625	ureidoglycolate dehydrogenase; Provisional; Region: PRK15025
99287001626	membrane protein FdrA; Validated; Region: PRK06091
99287001627	CoA binding domain; Region: CoA_binding; pfam02629
99287001628	CoA-ligase; Region: Ligase_CoA; pfam00549
99287001629	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
99287001630	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
99287001631	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
99287001632	putative substrate binding site [chemical binding]; other site
99287001633	nucleotide binding site [chemical binding]; other site
99287001634	nucleotide binding site [chemical binding]; other site
99287001635	homodimer interface [polypeptide binding]; other site
99287001636	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
99287001637	ATP-grasp domain; Region: ATP-grasp; pfam02222
99287001638	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
99287001639	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
99287001640	putative active site [active]
99287001641	putative metal binding site [ion binding]; other site
99287001642	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
99287001643	substrate binding site [chemical binding]; other site
99287001644	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
99287001645	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
99287001646	active site
99287001647	HIGH motif; other site
99287001648	KMSKS motif; other site
99287001649	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
99287001650	tRNA binding surface [nucleotide binding]; other site
99287001651	anticodon binding site; other site
99287001652	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
99287001653	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
99287001654	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99287001655	RNA binding surface [nucleotide binding]; other site
99287001656	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
99287001657	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
99287001658	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
99287001659	homodimer interface [polypeptide binding]; other site
99287001660	NADP binding site [chemical binding]; other site
99287001661	substrate binding site [chemical binding]; other site
99287001662	type-1 fimbrial protein subunit A; Provisional; Region: PRK15194
99287001663	fimbrial protein FimI; Provisional; Region: PRK15200
99287001664	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
99287001665	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287001666	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287001667	outer membrane usher protein FimD; Provisional; Region: PRK15198
99287001668	PapC N-terminal domain; Region: PapC_N; pfam13954
99287001669	Outer membrane usher protein; Region: Usher; pfam00577
99287001670	PapC C-terminal domain; Region: PapC_C; pfam13953
99287001671	fimbrial-like adhesin; Provisional; Region: fimH; PRK15199
99287001672	fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934
99287001673	transcriptional regulator FimZ; Provisional; Region: PRK09935
99287001674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287001675	active site
99287001676	phosphorylation site [posttranslational modification]
99287001677	intermolecular recognition site; other site
99287001678	dimerization interface [polypeptide binding]; other site
99287001679	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287001680	DNA binding residues [nucleotide binding]
99287001681	dimerization interface [polypeptide binding]; other site
99287001682	putative diguanylate cyclase; Provisional; Region: PRK13561
99287001683	fimbriae regulatory protein FimW; Provisional; Region: PRK15201
99287001684	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287001685	DNA binding residues [nucleotide binding]
99287001686	dimerization interface [polypeptide binding]; other site
99287001687	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
99287001688	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
99287001689	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
99287001690	Ligand binding site; other site
99287001691	Putative Catalytic site; other site
99287001692	DXD motif; other site
99287001693	Predicted membrane protein [Function unknown]; Region: COG2246
99287001694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287001695	ATP binding site [chemical binding]; other site
99287001696	Mg2+ binding site [ion binding]; other site
99287001697	G-X-G motif; other site
99287001698	Cupin; Region: Cupin_6; pfam12852
99287001699	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
99287001700	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287001701	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287001702	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
99287001703	Squalene epoxidase; Region: SE; cl17314
99287001704	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99287001705	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
99287001706	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
99287001707	Predicted membrane protein [Function unknown]; Region: COG3059
99287001708	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
99287001709	phenylalanine transporter; Provisional; Region: PRK10249
99287001710	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
99287001711	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
99287001712	Mechanosensitive ion channel; Region: MS_channel; pfam00924
99287001713	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
99287001714	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
99287001715	active site
99287001716	catalytic triad [active]
99287001717	oxyanion hole [active]
99287001718	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
99287001719	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
99287001720	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287001721	Walker A motif; other site
99287001722	ATP binding site [chemical binding]; other site
99287001723	Walker B motif; other site
99287001724	arginine finger; other site
99287001725	Transcriptional antiterminator [Transcription]; Region: COG3933
99287001726	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
99287001727	active pocket/dimerization site; other site
99287001728	active site
99287001729	phosphorylation site [posttranslational modification]
99287001730	PRD domain; Region: PRD; pfam00874
99287001731	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
99287001732	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
99287001733	putative active site [active]
99287001734	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
99287001735	dimer interface [polypeptide binding]; other site
99287001736	active site
99287001737	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
99287001738	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
99287001739	dimer interface [polypeptide binding]; other site
99287001740	active site
99287001741	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
99287001742	dimer interface [polypeptide binding]; other site
99287001743	active site
99287001744	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
99287001745	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
99287001746	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
99287001747	active site
99287001748	phosphorylation site [posttranslational modification]
99287001749	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
99287001750	active pocket/dimerization site; other site
99287001751	active site
99287001752	phosphorylation site [posttranslational modification]
99287001753	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
99287001754	dimer interface [polypeptide binding]; other site
99287001755	FMN binding site [chemical binding]; other site
99287001756	hypothetical protein; Provisional; Region: PRK10250
99287001757	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99287001758	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287001759	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
99287001760	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287001761	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287001762	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
99287001763	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
99287001764	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
99287001765	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
99287001766	outer membrane receptor FepA; Provisional; Region: PRK13524
99287001767	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99287001768	N-terminal plug; other site
99287001769	ligand-binding site [chemical binding]; other site
99287001770	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
99287001771	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
99287001772	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
99287001773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
99287001774	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
99287001775	Condensation domain; Region: Condensation; cl19241
99287001776	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
99287001777	acyl-activating enzyme (AAE) consensus motif; other site
99287001778	AMP binding site [chemical binding]; other site
99287001779	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
99287001780	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
99287001781	LPS O-antigen length regulator; Provisional; Region: PRK10381
99287001782	Chain length determinant protein; Region: Wzz; pfam02706
99287001783	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
99287001784	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
99287001785	Walker A/P-loop; other site
99287001786	ATP binding site [chemical binding]; other site
99287001787	Q-loop/lid; other site
99287001788	ABC transporter signature motif; other site
99287001789	Walker B; other site
99287001790	D-loop; other site
99287001791	H-loop/switch region; other site
99287001792	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
99287001793	ABC-ATPase subunit  interface; other site
99287001794	dimer interface [polypeptide binding]; other site
99287001795	putative PBP binding regions; other site
99287001796	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
99287001797	ABC-ATPase subunit  interface; other site
99287001798	dimer interface [polypeptide binding]; other site
99287001799	putative PBP binding regions; other site
99287001800	enterobactin exporter EntS; Provisional; Region: PRK10489
99287001801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287001802	putative substrate translocation pore; other site
99287001803	ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592
99287001804	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
99287001805	siderophore binding site; other site
99287001806	isochorismate synthase EntC; Provisional; Region: PRK15016
99287001807	chorismate binding enzyme; Region: Chorismate_bind; cl10555
99287001808	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
99287001809	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
99287001810	acyl-activating enzyme (AAE) consensus motif; other site
99287001811	active site
99287001812	AMP binding site [chemical binding]; other site
99287001813	substrate binding site [chemical binding]; other site
99287001814	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
99287001815	hydrophobic substrate binding pocket; other site
99287001816	active site
99287001817	conserved cis-peptide bond; other site
99287001818	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
99287001819	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
99287001820	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
99287001821	putative NAD(P) binding site [chemical binding]; other site
99287001822	active site
99287001823	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
99287001824	CoenzymeA binding site [chemical binding]; other site
99287001825	subunit interaction site [polypeptide binding]; other site
99287001826	PHB binding site; other site
99287001827	carbon starvation protein A; Provisional; Region: PRK15015
99287001828	Carbon starvation protein CstA; Region: CstA; pfam02554
99287001829	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
99287001830	Uncharacterized small protein [Function unknown]; Region: COG2879
99287001831	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
99287001832	putative active site [active]
99287001833	metal binding site [ion binding]; metal-binding site
99287001834	methionine aminotransferase; Validated; Region: PRK09082
99287001835	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99287001836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287001837	homodimer interface [polypeptide binding]; other site
99287001838	catalytic residue [active]
99287001839	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
99287001840	ParB-like nuclease domain; Region: ParBc; pfam02195
99287001841	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
99287001842	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
99287001843	Active Sites [active]
99287001844	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
99287001845	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
99287001846	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287001847	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287001848	dimerization interface [polypeptide binding]; other site
99287001849	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
99287001850	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
99287001851	dimerization domain [polypeptide binding]; other site
99287001852	dimer interface [polypeptide binding]; other site
99287001853	catalytic residues [active]
99287001854	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
99287001855	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
99287001856	dimer interface [polypeptide binding]; other site
99287001857	decamer (pentamer of dimers) interface [polypeptide binding]; other site
99287001858	catalytic triad [active]
99287001859	peroxidatic and resolving cysteines [active]
99287001860	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
99287001861	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
99287001862	catalytic residue [active]
99287001863	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
99287001864	catalytic residues [active]
99287001865	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287001866	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99287001867	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
99287001868	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
99287001869	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
99287001870	putative [4Fe-4S] binding site [ion binding]; other site
99287001871	putative molybdopterin cofactor binding site [chemical binding]; other site
99287001872	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
99287001873	molybdopterin cofactor binding site; other site
99287001874	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
99287001875	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287001876	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
99287001877	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99287001878	Ligand Binding Site [chemical binding]; other site
99287001879	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
99287001880	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
99287001881	NAD binding site [chemical binding]; other site
99287001882	catalytic Zn binding site [ion binding]; other site
99287001883	structural Zn binding site [ion binding]; other site
99287001884	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
99287001885	Rnk N-terminus; Region: Rnk_N; pfam14760
99287001886	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
99287001887	ribonuclease I; Provisional; Region: PRK10095
99287001888	CAS motifs; other site
99287001889	active site
99287001890	anion transporter; Region: dass; TIGR00785
99287001891	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
99287001892	transmembrane helices; other site
99287001893	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
99287001894	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
99287001895	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
99287001896	Coenzyme A transferase; Region: CoA_trans; cl17247
99287001897	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
99287001898	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
99287001899	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
99287001900	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
99287001901	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
99287001902	putative active site [active]
99287001903	(T/H)XGH motif; other site
99287001904	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
99287001905	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
99287001906	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99287001907	putative active site [active]
99287001908	heme pocket [chemical binding]; other site
99287001909	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
99287001910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287001911	ATP binding site [chemical binding]; other site
99287001912	Mg2+ binding site [ion binding]; other site
99287001913	G-X-G motif; other site
99287001914	two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046
99287001915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287001916	active site
99287001917	phosphorylation site [posttranslational modification]
99287001918	intermolecular recognition site; other site
99287001919	dimerization interface [polypeptide binding]; other site
99287001920	Transcriptional regulator; Region: CitT; pfam12431
99287001921	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
99287001922	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
99287001923	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
99287001924	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
99287001925	DNA-binding site [nucleotide binding]; DNA binding site
99287001926	RNA-binding motif; other site
99287001927	chromosome condensation membrane protein; Provisional; Region: PRK14196
99287001928	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
99287001929	putative active site [active]
99287001930	catalytic triad [active]
99287001931	putative dimer interface [polypeptide binding]; other site
99287001932	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
99287001933	lipoyl synthase; Provisional; Region: PRK05481
99287001934	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287001935	FeS/SAM binding site; other site
99287001936	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
99287001937	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287001938	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287001939	dimerization interface [polypeptide binding]; other site
99287001940	lipoate-protein ligase B; Provisional; Region: PRK14342
99287001941	hypothetical protein; Provisional; Region: PRK04998
99287001942	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
99287001943	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
99287001944	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
99287001945	rare lipoprotein A; Provisional; Region: PRK10672
99287001946	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
99287001947	Sporulation related domain; Region: SPOR; pfam05036
99287001948	cell wall shape-determining protein; Provisional; Region: PRK10794
99287001949	penicillin-binding protein 2; Provisional; Region: PRK10795
99287001950	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
99287001951	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
99287001952	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
99287001953	ribosome-associated protein; Provisional; Region: PRK11538
99287001954	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
99287001955	catalytic core [active]
99287001956	threonine-phosphate decarboxylase; Provisional; Region: PRK08056
99287001957	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99287001958	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287001959	homodimer interface [polypeptide binding]; other site
99287001960	catalytic residue [active]
99287001961	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
99287001962	active site
99287001963	(T/H)XGH motif; other site
99287001964	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
99287001965	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
99287001966	Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840
99287001967	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
99287001968	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
99287001969	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
99287001970	active site
99287001971	HIGH motif; other site
99287001972	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
99287001973	KMSKS motif; other site
99287001974	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
99287001975	tRNA binding surface [nucleotide binding]; other site
99287001976	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
99287001977	Propionate catabolism activator; Region: PrpR_N; pfam06506
99287001978	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
99287001979	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287001980	Walker A motif; other site
99287001981	ATP binding site [chemical binding]; other site
99287001982	Walker B motif; other site
99287001983	arginine finger; other site
99287001984	hypothetical protein; Provisional; Region: PRK11032
99287001985	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
99287001986	Sel1-like repeats; Region: SEL1; smart00671
99287001987	Sel1-like repeats; Region: SEL1; smart00671
99287001988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287001989	binding surface
99287001990	TPR motif; other site
99287001991	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
99287001992	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99287001993	HSP70 interaction site [polypeptide binding]; other site
99287001994	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
99287001995	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99287001996	HSP70 interaction site [polypeptide binding]; other site
99287001997	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
99287001998	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
99287001999	nucleotide binding site [chemical binding]; other site
99287002000	putative NEF/HSP70 interaction site [polypeptide binding]; other site
99287002001	SBD interface [polypeptide binding]; other site
99287002002	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
99287002003	active site
99287002004	tetramer interface [polypeptide binding]; other site
99287002005	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
99287002006	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
99287002007	Walker A/P-loop; other site
99287002008	ATP binding site [chemical binding]; other site
99287002009	Q-loop/lid; other site
99287002010	ABC transporter signature motif; other site
99287002011	Walker B; other site
99287002012	D-loop; other site
99287002013	H-loop/switch region; other site
99287002014	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
99287002015	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287002016	dimer interface [polypeptide binding]; other site
99287002017	conserved gate region; other site
99287002018	putative PBP binding loops; other site
99287002019	ABC-ATPase subunit interface; other site
99287002020	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
99287002021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287002022	dimer interface [polypeptide binding]; other site
99287002023	conserved gate region; other site
99287002024	putative PBP binding loops; other site
99287002025	ABC-ATPase subunit interface; other site
99287002026	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
99287002027	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287002028	substrate binding pocket [chemical binding]; other site
99287002029	membrane-bound complex binding site; other site
99287002030	hinge residues; other site
99287002031	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
99287002032	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
99287002033	putative active site [active]
99287002034	catalytic triad [active]
99287002035	putative dimer interface [polypeptide binding]; other site
99287002036	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
99287002037	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
99287002038	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
99287002039	Transporter associated domain; Region: CorC_HlyC; smart01091
99287002040	metal-binding heat shock protein; Provisional; Region: PRK00016
99287002041	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
99287002042	PhoH-like protein; Region: PhoH; pfam02562
99287002043	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
99287002044	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
99287002045	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287002046	FeS/SAM binding site; other site
99287002047	TRAM domain; Region: TRAM; pfam01938
99287002048	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
99287002049	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
99287002050	asparagine synthetase B; Provisional; Region: asnB; PRK09431
99287002051	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
99287002052	active site
99287002053	dimer interface [polypeptide binding]; other site
99287002054	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
99287002055	Ligand Binding Site [chemical binding]; other site
99287002056	Molecular Tunnel; other site
99287002057	UMP phosphatase; Provisional; Region: PRK10444
99287002058	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287002059	active site
99287002060	motif I; other site
99287002061	motif II; other site
99287002062	MarR family; Region: MarR_2; cl17246
99287002063	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
99287002064	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99287002065	nucleotide binding site [chemical binding]; other site
99287002066	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
99287002067	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
99287002068	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
99287002069	active site
99287002070	dimer interface [polypeptide binding]; other site
99287002071	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
99287002072	active site
99287002073	trimer interface [polypeptide binding]; other site
99287002074	allosteric site; other site
99287002075	active site lid [active]
99287002076	hexamer (dimer of trimers) interface [polypeptide binding]; other site
99287002077	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
99287002078	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
99287002079	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
99287002080	active site turn [active]
99287002081	phosphorylation site [posttranslational modification]
99287002082	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
99287002083	HPr interaction site; other site
99287002084	glycerol kinase (GK) interaction site [polypeptide binding]; other site
99287002085	active site
99287002086	phosphorylation site [posttranslational modification]
99287002087	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
99287002088	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
99287002089	active site
99287002090	HIGH motif; other site
99287002091	KMSKS motif; other site
99287002092	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
99287002093	outer membrane porin, OprD family; Region: OprD; pfam03573
99287002094	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
99287002095	YbfN-like lipoprotein; Region: YbfN; pfam13982
99287002096	citrate-proton symporter; Provisional; Region: PRK15075
99287002097	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287002098	putative substrate translocation pore; other site
99287002099	tricarballylate utilization protein B; Provisional; Region: PRK15033
99287002100	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
99287002101	tricarballylate dehydrogenase; Validated; Region: PRK08274
99287002102	precorrin 3B synthase CobZ; Region: CobZ_N-term; TIGR02485
99287002103	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287002104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287002105	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287002106	dimerization interface [polypeptide binding]; other site
99287002107	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
99287002108	metal binding site 2 [ion binding]; metal-binding site
99287002109	putative DNA binding helix; other site
99287002110	metal binding site 1 [ion binding]; metal-binding site
99287002111	dimer interface [polypeptide binding]; other site
99287002112	structural Zn2+ binding site [ion binding]; other site
99287002113	flavodoxin FldA; Validated; Region: PRK09267
99287002114	LexA regulated protein; Provisional; Region: PRK11675
99287002115	acyl-CoA esterase; Provisional; Region: PRK10673
99287002116	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
99287002117	replication initiation regulator SeqA; Provisional; Region: PRK11187
99287002118	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
99287002119	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
99287002120	active site
99287002121	substrate binding site [chemical binding]; other site
99287002122	metal binding site [ion binding]; metal-binding site
99287002123	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
99287002124	putrescine transporter; Provisional; Region: potE; PRK10655
99287002125	ornithine decarboxylase; Provisional; Region: PRK13578
99287002126	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
99287002127	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
99287002128	homodimer interface [polypeptide binding]; other site
99287002129	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287002130	catalytic residue [active]
99287002131	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
99287002132	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
99287002133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287002134	active site
99287002135	phosphorylation site [posttranslational modification]
99287002136	intermolecular recognition site; other site
99287002137	dimerization interface [polypeptide binding]; other site
99287002138	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287002139	DNA binding site [nucleotide binding]
99287002140	sensor protein KdpD; Provisional; Region: PRK10490
99287002141	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
99287002142	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
99287002143	Ligand Binding Site [chemical binding]; other site
99287002144	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
99287002145	GAF domain; Region: GAF_3; pfam13492
99287002146	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287002147	dimer interface [polypeptide binding]; other site
99287002148	phosphorylation site [posttranslational modification]
99287002149	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287002150	ATP binding site [chemical binding]; other site
99287002151	Mg2+ binding site [ion binding]; other site
99287002152	G-X-G motif; other site
99287002153	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
99287002154	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
99287002155	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99287002156	Soluble P-type ATPase [General function prediction only]; Region: COG4087
99287002157	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
99287002158	potassium-transporting ATPase subunit F; Provisional; Region: kdpF; PRK14748
99287002159	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
99287002160	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
99287002161	DNA photolyase; Region: DNA_photolyase; pfam00875
99287002162	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
99287002163	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
99287002164	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287002165	putative substrate translocation pore; other site
99287002166	metal-binding protein; Provisional; Region: PRK10799
99287002167	Allophanate hydrolase subunit 1; Region: AHS1; cl19310
99287002168	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
99287002169	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
99287002170	putative active site [active]
99287002171	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
99287002172	active site
99287002173	DNA binding site [nucleotide binding]
99287002174	Int/Topo IB signature motif; other site
99287002175	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
99287002176	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
99287002177	UDP-galactopyranose mutase; Region: GLF; pfam03275
99287002178	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
99287002179	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99287002180	active site
99287002181	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
99287002182	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99287002183	putative ADP-binding pocket [chemical binding]; other site
99287002184	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
99287002185	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
99287002186	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
99287002187	Walker A/P-loop; other site
99287002188	ATP binding site [chemical binding]; other site
99287002189	Q-loop/lid; other site
99287002190	ABC transporter signature motif; other site
99287002191	Walker B; other site
99287002192	D-loop; other site
99287002193	H-loop/switch region; other site
99287002194	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
99287002195	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99287002196	active site
99287002197	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99287002198	active site
99287002199	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
99287002200	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
99287002201	endonuclease VIII; Provisional; Region: PRK10445
99287002202	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
99287002203	DNA binding site [nucleotide binding]
99287002204	catalytic residue [active]
99287002205	putative catalytic residues [active]
99287002206	H2TH interface [polypeptide binding]; other site
99287002207	intercalation triad [nucleotide binding]; other site
99287002208	substrate specificity determining residue; other site
99287002209	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
99287002210	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
99287002211	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
99287002212	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
99287002213	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
99287002214	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
99287002215	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
99287002216	dimer interface [polypeptide binding]; other site
99287002217	active site
99287002218	citrylCoA binding site [chemical binding]; other site
99287002219	NADH binding [chemical binding]; other site
99287002220	cationic pore residues; other site
99287002221	oxalacetate/citrate binding site [chemical binding]; other site
99287002222	coenzyme A binding site [chemical binding]; other site
99287002223	catalytic triad [active]
99287002224	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
99287002225	Iron-sulfur protein interface; other site
99287002226	proximal quinone binding site [chemical binding]; other site
99287002227	SdhD (CybS) interface [polypeptide binding]; other site
99287002228	proximal heme binding site [chemical binding]; other site
99287002229	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
99287002230	SdhC subunit interface [polypeptide binding]; other site
99287002231	proximal heme binding site [chemical binding]; other site
99287002232	cardiolipin binding site; other site
99287002233	Iron-sulfur protein interface; other site
99287002234	proximal quinone binding site [chemical binding]; other site
99287002235	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
99287002236	L-aspartate oxidase; Provisional; Region: PRK06175
99287002237	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
99287002238	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
99287002239	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
99287002240	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
99287002241	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
99287002242	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
99287002243	TPP-binding site [chemical binding]; other site
99287002244	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
99287002245	dimer interface [polypeptide binding]; other site
99287002246	PYR/PP interface [polypeptide binding]; other site
99287002247	TPP binding site [chemical binding]; other site
99287002248	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
99287002249	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
99287002250	E3 interaction surface; other site
99287002251	lipoyl attachment site [posttranslational modification]; other site
99287002252	e3 binding domain; Region: E3_binding; pfam02817
99287002253	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
99287002254	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
99287002255	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
99287002256	CoA-ligase; Region: Ligase_CoA; pfam00549
99287002257	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
99287002258	CoA binding domain; Region: CoA_binding; pfam02629
99287002259	CoA-ligase; Region: Ligase_CoA; pfam00549
99287002260	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
99287002261	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
99287002262	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
99287002263	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
99287002264	hypothetical protein; Provisional; Region: PRK10588
99287002265	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
99287002266	active site
99287002267	colicin uptake protein TolQ; Provisional; Region: PRK10801
99287002268	colicin uptake protein TolR; Provisional; Region: PRK11024
99287002269	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
99287002270	TolA C-terminal; Region: TolA; pfam06519
99287002271	translocation protein TolB; Provisional; Region: tolB; PRK03629
99287002272	TolB amino-terminal domain; Region: TolB_N; pfam04052
99287002273	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
99287002274	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
99287002275	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
99287002276	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
99287002277	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
99287002278	ligand binding site [chemical binding]; other site
99287002279	tol-pal system protein YbgF; Provisional; Region: PRK10803
99287002280	YfhG lipoprotein; Region: Lipoprotein_20; cl08141
99287002281	Tetratricopeptide repeat; Region: TPR_6; pfam13174
99287002282	Tetratricopeptide repeat; Region: TPR_6; pfam13174
99287002283	quinolinate synthetase; Provisional; Region: PRK09375
99287002284	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
99287002285	zinc transporter ZitB; Provisional; Region: PRK03557
99287002286	YbgS-like protein; Region: YbgS; pfam13985
99287002287	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
99287002288	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
99287002289	fumarate hydratase; Provisional; Region: PRK06246
99287002290	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287002291	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287002292	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
99287002293	dimerization interface [polypeptide binding]; other site
99287002294	cell density-dependent motility repressor; Provisional; Region: PRK10082
99287002295	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287002296	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
99287002297	dimerization interface [polypeptide binding]; other site
99287002298	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
99287002299	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
99287002300	transmembrane helices; other site
99287002301	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
99287002302	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15477
99287002303	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
99287002304	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
99287002305	ABC-ATPase subunit  interface; other site
99287002306	dimer interface [polypeptide binding]; other site
99287002307	putative PBP binding regions; other site
99287002308	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
99287002309	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
99287002310	Walker A/P-loop; other site
99287002311	ATP binding site [chemical binding]; other site
99287002312	Q-loop/lid; other site
99287002313	ABC transporter signature motif; other site
99287002314	Walker B; other site
99287002315	D-loop; other site
99287002316	H-loop/switch region; other site
99287002317	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
99287002318	catalytic core [active]
99287002319	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
99287002320	active site
99287002321	catalytic residues [active]
99287002322	galactokinase; Provisional; Region: PRK05101
99287002323	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
99287002324	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
99287002325	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
99287002326	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
99287002327	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
99287002328	dimer interface [polypeptide binding]; other site
99287002329	active site
99287002330	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
99287002331	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
99287002332	NAD binding site [chemical binding]; other site
99287002333	homodimer interface [polypeptide binding]; other site
99287002334	active site
99287002335	substrate binding site [chemical binding]; other site
99287002336	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714
99287002337	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
99287002338	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287002339	Walker A/P-loop; other site
99287002340	ATP binding site [chemical binding]; other site
99287002341	Q-loop/lid; other site
99287002342	ABC transporter signature motif; other site
99287002343	Walker B; other site
99287002344	D-loop; other site
99287002345	H-loop/switch region; other site
99287002346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287002347	Walker A/P-loop; other site
99287002348	ATP binding site [chemical binding]; other site
99287002349	Q-loop/lid; other site
99287002350	ABC transporter signature motif; other site
99287002351	Walker B; other site
99287002352	D-loop; other site
99287002353	H-loop/switch region; other site
99287002354	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
99287002355	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
99287002356	molybdenum-pterin binding domain; Region: Mop; TIGR00638
99287002357	TOBE domain; Region: TOBE; pfam03459
99287002358	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
99287002359	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287002360	substrate binding pocket [chemical binding]; other site
99287002361	membrane-bound complex binding site; other site
99287002362	hinge residues; other site
99287002363	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
99287002364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287002365	dimer interface [polypeptide binding]; other site
99287002366	conserved gate region; other site
99287002367	putative PBP binding loops; other site
99287002368	ABC-ATPase subunit interface; other site
99287002369	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
99287002370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287002371	Walker A/P-loop; other site
99287002372	ATP binding site [chemical binding]; other site
99287002373	Q-loop/lid; other site
99287002374	ABC transporter signature motif; other site
99287002375	Walker B; other site
99287002376	D-loop; other site
99287002377	H-loop/switch region; other site
99287002378	molybdenum-pterin binding domain; Region: Mop; TIGR00638
99287002379	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
99287002380	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287002381	active site
99287002382	motif I; other site
99287002383	motif II; other site
99287002384	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
99287002385	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774
99287002386	6-phosphogluconolactonase; Provisional; Region: PRK11028
99287002387	acyl-CoA thioesterase; Provisional; Region: PRK10531
99287002388	Pectinesterase; Region: Pectinesterase; cl01911
99287002389	imidazolonepropionase; Validated; Region: PRK09356
99287002390	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
99287002391	active site
99287002392	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
99287002393	putative active site [active]
99287002394	putative metal binding site [ion binding]; other site
99287002395	histidine utilization repressor; Provisional; Region: PRK14999
99287002396	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287002397	DNA-binding site [nucleotide binding]; DNA binding site
99287002398	UTRA domain; Region: UTRA; pfam07702
99287002399	Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221
99287002400	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
99287002401	active sites [active]
99287002402	tetramer interface [polypeptide binding]; other site
99287002403	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
99287002404	substrate binding site [chemical binding]; other site
99287002405	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
99287002406	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
99287002407	inhibitor-cofactor binding pocket; inhibition site
99287002408	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287002409	catalytic residue [active]
99287002410	biotin synthase; Provisional; Region: PRK15108
99287002411	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287002412	FeS/SAM binding site; other site
99287002413	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
99287002414	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
99287002415	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
99287002416	substrate-cofactor binding pocket; other site
99287002417	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287002418	catalytic residue [active]
99287002419	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
99287002420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287002421	S-adenosylmethionine binding site [chemical binding]; other site
99287002422	AAA domain; Region: AAA_26; pfam13500
99287002423	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
99287002424	excinuclease ABC subunit B; Provisional; Region: PRK05298
99287002425	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99287002426	ATP binding site [chemical binding]; other site
99287002427	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287002428	nucleotide binding region [chemical binding]; other site
99287002429	ATP-binding site [chemical binding]; other site
99287002430	Ultra-violet resistance protein B; Region: UvrB; pfam12344
99287002431	UvrB/uvrC motif; Region: UVR; pfam02151
99287002432	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
99287002433	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
99287002434	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
99287002435	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116
99287002436	Leucine-rich repeats; other site
99287002437	Substrate binding site [chemical binding]; other site
99287002438	C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496
99287002439	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
99287002440	phosphate binding site [ion binding]; other site
99287002441	putative substrate binding pocket [chemical binding]; other site
99287002442	dimer interface [polypeptide binding]; other site
99287002443	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
99287002444	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287002445	FeS/SAM binding site; other site
99287002446	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
99287002447	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
99287002448	MPT binding site; other site
99287002449	trimer interface [polypeptide binding]; other site
99287002450	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
99287002451	trimer interface [polypeptide binding]; other site
99287002452	dimer interface [polypeptide binding]; other site
99287002453	putative active site [active]
99287002454	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
99287002455	MoaE interaction surface [polypeptide binding]; other site
99287002456	MoeB interaction surface [polypeptide binding]; other site
99287002457	thiocarboxylated glycine; other site
99287002458	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
99287002459	MoaE homodimer interface [polypeptide binding]; other site
99287002460	MoaD interaction [polypeptide binding]; other site
99287002461	active site residues [active]
99287002462	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
99287002463	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
99287002464	Predicted integral membrane protein [Function unknown]; Region: COG0392
99287002465	cardiolipin synthase 2; Provisional; Region: PRK11263
99287002466	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
99287002467	putative active site [active]
99287002468	catalytic site [active]
99287002469	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
99287002470	putative active site [active]
99287002471	catalytic site [active]
99287002472	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
99287002473	putative catalytic site [active]
99287002474	putative metal binding site [ion binding]; other site
99287002475	putative phosphate binding site [ion binding]; other site
99287002476	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
99287002477	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
99287002478	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
99287002479	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
99287002480	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
99287002481	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
99287002482	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
99287002483	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
99287002484	Walker A/P-loop; other site
99287002485	ATP binding site [chemical binding]; other site
99287002486	Q-loop/lid; other site
99287002487	ABC transporter signature motif; other site
99287002488	Walker B; other site
99287002489	D-loop; other site
99287002490	H-loop/switch region; other site
99287002491	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
99287002492	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
99287002493	Walker A/P-loop; other site
99287002494	ATP binding site [chemical binding]; other site
99287002495	Q-loop/lid; other site
99287002496	ABC transporter signature motif; other site
99287002497	Walker B; other site
99287002498	D-loop; other site
99287002499	H-loop/switch region; other site
99287002500	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
99287002501	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99287002502	HlyD family secretion protein; Region: HlyD_3; pfam13437
99287002503	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
99287002504	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287002505	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
99287002506	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
99287002507	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
99287002508	ATP binding site [chemical binding]; other site
99287002509	Mg++ binding site [ion binding]; other site
99287002510	motif III; other site
99287002511	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287002512	nucleotide binding region [chemical binding]; other site
99287002513	ATP-binding site [chemical binding]; other site
99287002514	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
99287002515	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
99287002516	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
99287002517	glycosyl transferase family protein; Provisional; Region: PRK08136
99287002518	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
99287002519	hypothetical protein; Provisional; Region: PRK10259
99287002520	hypothetical protein; Provisional; Region: PRK11019
99287002521	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
99287002522	putative mechanosensitive channel protein; Provisional; Region: PRK11465
99287002523	Mechanosensitive ion channel; Region: MS_channel; pfam00924
99287002524	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
99287002525	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
99287002526	Walker A/P-loop; other site
99287002527	ATP binding site [chemical binding]; other site
99287002528	Q-loop/lid; other site
99287002529	ABC transporter signature motif; other site
99287002530	Walker B; other site
99287002531	D-loop; other site
99287002532	H-loop/switch region; other site
99287002533	glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494
99287002534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287002535	dimer interface [polypeptide binding]; other site
99287002536	conserved gate region; other site
99287002537	putative PBP binding loops; other site
99287002538	ABC-ATPase subunit interface; other site
99287002539	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
99287002540	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287002541	substrate binding pocket [chemical binding]; other site
99287002542	membrane-bound complex binding site; other site
99287002543	hinge residues; other site
99287002544	Ferritin-like domain; Region: Ferritin; pfam00210
99287002545	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
99287002546	dimerization interface [polypeptide binding]; other site
99287002547	DPS ferroxidase diiron center [ion binding]; other site
99287002548	ion pore; other site
99287002549	threonine and homoserine efflux system; Provisional; Region: PRK10532
99287002550	EamA-like transporter family; Region: EamA; pfam00892
99287002551	outer membrane protein X; Provisional; Region: ompX; PRK09408
99287002552	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
99287002553	Sulfatase; Region: Sulfatase; pfam00884
99287002554	manganese transport regulator MntR; Provisional; Region: PRK11050
99287002555	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
99287002556	Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
99287002557	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
99287002558	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
99287002559	transmembrane helices; other site
99287002560	L,D-transpeptidase; Provisional; Region: PRK10260
99287002561	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
99287002562	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
99287002563	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
99287002564	ABC transporter; Region: ABC_tran_2; pfam12848
99287002565	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
99287002566	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
99287002567	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
99287002568	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287002569	motif II; other site
99287002570	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287002571	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
99287002572	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
99287002573	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287002574	active site
99287002575	motif I; other site
99287002576	motif II; other site
99287002577	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
99287002578	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
99287002579	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
99287002580	dimer interface [polypeptide binding]; other site
99287002581	active site
99287002582	glycine loop; other site
99287002583	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
99287002584	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962
99287002585	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
99287002586	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
99287002587	ATP binding site [chemical binding]; other site
99287002588	substrate interface [chemical binding]; other site
99287002589	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
99287002590	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
99287002591	dimer interface [polypeptide binding]; other site
99287002592	putative functional site; other site
99287002593	putative MPT binding site; other site
99287002594	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
99287002595	catalytic nucleophile [active]
99287002596	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
99287002597	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99287002598	Walker A/P-loop; other site
99287002599	ATP binding site [chemical binding]; other site
99287002600	Q-loop/lid; other site
99287002601	ABC transporter signature motif; other site
99287002602	Walker B; other site
99287002603	D-loop; other site
99287002604	H-loop/switch region; other site
99287002605	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
99287002606	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99287002607	Walker A/P-loop; other site
99287002608	ATP binding site [chemical binding]; other site
99287002609	Q-loop/lid; other site
99287002610	ABC transporter signature motif; other site
99287002611	Walker B; other site
99287002612	D-loop; other site
99287002613	H-loop/switch region; other site
99287002614	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
99287002615	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
99287002616	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
99287002617	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
99287002618	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287002619	dimer interface [polypeptide binding]; other site
99287002620	conserved gate region; other site
99287002621	putative PBP binding loops; other site
99287002622	ABC-ATPase subunit interface; other site
99287002623	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
99287002624	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
99287002625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287002626	dimer interface [polypeptide binding]; other site
99287002627	conserved gate region; other site
99287002628	putative PBP binding loops; other site
99287002629	ABC-ATPase subunit interface; other site
99287002630	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
99287002631	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
99287002632	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287002633	FeS/SAM binding site; other site
99287002634	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
99287002635	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
99287002636	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
99287002637	Ligand binding site [chemical binding]; other site
99287002638	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
99287002639	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
99287002640	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
99287002641	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
99287002642	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
99287002643	active site
99287002644	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
99287002645	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287002646	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
99287002647	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287002648	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287002649	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
99287002650	putative dimerization interface [polypeptide binding]; other site
99287002651	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
99287002652	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
99287002653	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
99287002654	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
99287002655	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
99287002656	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
99287002657	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
99287002658	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
99287002659	putative C-terminal domain interface [polypeptide binding]; other site
99287002660	putative GSH binding site (G-site) [chemical binding]; other site
99287002661	putative dimer interface [polypeptide binding]; other site
99287002662	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
99287002663	N-terminal domain interface [polypeptide binding]; other site
99287002664	dimer interface [polypeptide binding]; other site
99287002665	substrate binding pocket (H-site) [chemical binding]; other site
99287002666	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
99287002667	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
99287002668	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
99287002669	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
99287002670	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
99287002671	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287002672	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
99287002673	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
99287002674	active site
99287002675	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
99287002676	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287002677	putative substrate translocation pore; other site
99287002678	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
99287002679	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287002680	active site
99287002681	motif I; other site
99287002682	motif II; other site
99287002683	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287002684	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
99287002685	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287002686	putative substrate translocation pore; other site
99287002687	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
99287002688	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287002689	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
99287002690	putative transporter; Provisional; Region: PRK04972
99287002691	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
99287002692	TrkA-C domain; Region: TrkA_C; pfam02080
99287002693	TrkA-C domain; Region: TrkA_C; pfam02080
99287002694	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
99287002695	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
99287002696	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
99287002697	GSH binding site [chemical binding]; other site
99287002698	catalytic residues [active]
99287002699	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
99287002700	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
99287002701	dimer interface [polypeptide binding]; other site
99287002702	FMN binding site [chemical binding]; other site
99287002703	NADPH bind site [chemical binding]; other site
99287002704	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
99287002705	RimK-like ATP-grasp domain; Region: RimK; pfam08443
99287002706	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
99287002707	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
99287002708	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
99287002709	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287002710	Walker A/P-loop; other site
99287002711	ATP binding site [chemical binding]; other site
99287002712	Q-loop/lid; other site
99287002713	ABC transporter signature motif; other site
99287002714	Walker B; other site
99287002715	D-loop; other site
99287002716	H-loop/switch region; other site
99287002717	TOBE domain; Region: TOBE_2; pfam08402
99287002718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287002719	dimer interface [polypeptide binding]; other site
99287002720	conserved gate region; other site
99287002721	putative PBP binding loops; other site
99287002722	ABC-ATPase subunit interface; other site
99287002723	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
99287002724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287002725	dimer interface [polypeptide binding]; other site
99287002726	conserved gate region; other site
99287002727	putative PBP binding loops; other site
99287002728	ABC-ATPase subunit interface; other site
99287002729	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
99287002730	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
99287002731	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287002732	S-adenosylmethionine binding site [chemical binding]; other site
99287002733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
99287002734	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
99287002735	active site
99287002736	P-loop; other site
99287002737	phosphorylation site [posttranslational modification]
99287002738	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
99287002739	Sulfatase; Region: Sulfatase; cl19157
99287002740	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
99287002741	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287002742	substrate binding pocket [chemical binding]; other site
99287002743	membrane-bound complex binding site; other site
99287002744	hinge residues; other site
99287002745	arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122
99287002746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287002747	dimer interface [polypeptide binding]; other site
99287002748	conserved gate region; other site
99287002749	putative PBP binding loops; other site
99287002750	ABC-ATPase subunit interface; other site
99287002751	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
99287002752	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287002753	dimer interface [polypeptide binding]; other site
99287002754	conserved gate region; other site
99287002755	putative PBP binding loops; other site
99287002756	ABC-ATPase subunit interface; other site
99287002757	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
99287002758	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287002759	substrate binding pocket [chemical binding]; other site
99287002760	membrane-bound complex binding site; other site
99287002761	hinge residues; other site
99287002762	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
99287002763	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287002764	Walker A/P-loop; other site
99287002765	ATP binding site [chemical binding]; other site
99287002766	Q-loop/lid; other site
99287002767	ABC transporter signature motif; other site
99287002768	Walker B; other site
99287002769	D-loop; other site
99287002770	H-loop/switch region; other site
99287002771	putative lipoprotein; Provisional; Region: PRK10533
99287002772	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
99287002773	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
99287002774	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
99287002775	Int/Topo IB signature motif; other site
99287002776	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
99287002777	ORF6N domain; Region: ORF6N; pfam10543
99287002778	Predicted transcriptional regulator [Transcription]; Region: COG2932
99287002779	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287002780	non-specific DNA binding site [nucleotide binding]; other site
99287002781	salt bridge; other site
99287002782	sequence-specific DNA binding site [nucleotide binding]; other site
99287002783	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
99287002784	Catalytic site [active]
99287002785	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287002786	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
99287002787	non-specific DNA binding site [nucleotide binding]; other site
99287002788	salt bridge; other site
99287002789	sequence-specific DNA binding site [nucleotide binding]; other site
99287002790	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
99287002791	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99287002792	ATP binding site [chemical binding]; other site
99287002793	putative Mg++ binding site [ion binding]; other site
99287002794	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287002795	nucleotide binding region [chemical binding]; other site
99287002796	ATP-binding site [chemical binding]; other site
99287002797	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
99287002798	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
99287002799	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
99287002800	active site
99287002801	metal binding site [ion binding]; metal-binding site
99287002802	interdomain interaction site; other site
99287002803	Antitermination protein; Region: Antiterm; pfam03589
99287002804	Protein of unknown function (DUF1356); Region: DUF1356; pfam07092
99287002805	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048
99287002806	Antitermination protein; Region: Antiterm; pfam03589
99287002807	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
99287002808	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
99287002809	Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106
99287002810	Predicted chitinase [General function prediction only]; Region: COG3179
99287002811	catalytic residue [active]
99287002812	Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245
99287002813	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
99287002814	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
99287002815	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
99287002816	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
99287002817	oligomer interface [polypeptide binding]; other site
99287002818	active site residues [active]
99287002819	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
99287002820	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
99287002821	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
99287002822	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
99287002823	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
99287002824	Phage tail protein; Region: Phage_tail_3; pfam08813
99287002825	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
99287002826	Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106
99287002827	Minor tail protein T; Region: Phage_tail_T; pfam06223
99287002828	Phage-related minor tail protein [Function unknown]; Region: COG5281
99287002829	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
99287002830	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901
99287002831	Phage-related protein [Function unknown]; Region: COG4718
99287002832	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
99287002833	Phage-related protein [Function unknown]; Region: gp18; COG4672
99287002834	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
99287002835	MPN+ (JAMM) motif; other site
99287002836	Zinc-binding site [ion binding]; other site
99287002837	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
99287002838	NlpC/P60 family; Region: NLPC_P60; cl17555
99287002839	Phage-related protein, tail component [Function unknown]; Region: COG4723
99287002840	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
99287002841	E-class dimer interface [polypeptide binding]; other site
99287002842	P-class dimer interface [polypeptide binding]; other site
99287002843	active site
99287002844	Cu2+ binding site [ion binding]; other site
99287002845	Zn2+ binding site [ion binding]; other site
99287002846	Phage-related protein, tail component [Function unknown]; Region: COG4733
99287002847	Putative phage tail protein; Region: Phage-tail_3; pfam13550
99287002848	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
99287002849	Interdomain contacts; other site
99287002850	Cytokine receptor motif; other site
99287002851	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
99287002852	Fibronectin type III protein; Region: DUF3672; pfam12421
99287002853	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
99287002854	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
99287002855	Phage Tail Collar Domain; Region: Collar; pfam07484
99287002856	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
99287002857	Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409
99287002858	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
99287002859	catalytic site [active]
99287002860	Asp-box motif; other site
99287002861	hypothetical protein; Provisional; Region: PRK02877
99287002862	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
99287002863	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
99287002864	amidase catalytic site [active]
99287002865	Zn binding residues [ion binding]; other site
99287002866	substrate binding site [chemical binding]; other site
99287002867	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
99287002868	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99287002869	NAD(P) binding site [chemical binding]; other site
99287002870	active site
99287002871	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
99287002872	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
99287002873	putative NAD(P) binding site [chemical binding]; other site
99287002874	putative active site [active]
99287002875	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
99287002876	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
99287002877	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
99287002878	tetramer interface [polypeptide binding]; other site
99287002879	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287002880	catalytic residue [active]
99287002881	pyruvate dehydrogenase; Provisional; Region: PRK09124
99287002882	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
99287002883	PYR/PP interface [polypeptide binding]; other site
99287002884	dimer interface [polypeptide binding]; other site
99287002885	tetramer interface [polypeptide binding]; other site
99287002886	TPP binding site [chemical binding]; other site
99287002887	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
99287002888	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
99287002889	TPP-binding site [chemical binding]; other site
99287002890	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
99287002891	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
99287002892	FAD binding pocket [chemical binding]; other site
99287002893	FAD binding motif [chemical binding]; other site
99287002894	phosphate binding motif [ion binding]; other site
99287002895	beta-alpha-beta structure motif; other site
99287002896	NAD binding pocket [chemical binding]; other site
99287002897	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99287002898	catalytic loop [active]
99287002899	iron binding site [ion binding]; other site
99287002900	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
99287002901	cubane metal cluster [ion binding]; other site
99287002902	hybrid metal cluster; other site
99287002903	Predicted membrane protein [Function unknown]; Region: COG2431
99287002904	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
99287002905	AAA domain; Region: AAA_21; pfam13304
99287002906	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
99287002907	putative active site [active]
99287002908	putative metal-binding site [ion binding]; other site
99287002909	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
99287002910	macrolide transporter subunit MacA; Provisional; Region: PRK11578
99287002911	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99287002912	HlyD family secretion protein; Region: HlyD_3; pfam13437
99287002913	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
99287002914	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
99287002915	Walker A/P-loop; other site
99287002916	ATP binding site [chemical binding]; other site
99287002917	Q-loop/lid; other site
99287002918	ABC transporter signature motif; other site
99287002919	Walker B; other site
99287002920	D-loop; other site
99287002921	H-loop/switch region; other site
99287002922	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99287002923	FtsX-like permease family; Region: FtsX; pfam02687
99287002924	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
99287002925	DNA-binding site [nucleotide binding]; DNA binding site
99287002926	RNA-binding motif; other site
99287002927	Uncharacterized conserved protein [Function unknown]; Region: COG2127
99287002928	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
99287002929	Clp amino terminal domain; Region: Clp_N; pfam02861
99287002930	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287002931	Walker A motif; other site
99287002932	ATP binding site [chemical binding]; other site
99287002933	Walker B motif; other site
99287002934	arginine finger; other site
99287002935	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287002936	Walker A motif; other site
99287002937	ATP binding site [chemical binding]; other site
99287002938	Walker B motif; other site
99287002939	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
99287002940	Transposase IS200 like; Region: Y1_Tnp; pfam01797
99287002941	Integrase core domain; Region: rve; pfam00665
99287002942	Integrase core domain; Region: rve_3; pfam13683
99287002943	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
99287002944	Helix-turn-helix domain; Region: HTH_28; pfam13518
99287002945	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
99287002946	catalytic triad [active]
99287002947	dimer interface [polypeptide binding]; other site
99287002948	conserved cis-peptide bond; other site
99287002949	Pirin-related protein [General function prediction only]; Region: COG1741
99287002950	Pirin; Region: Pirin; pfam02678
99287002951	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
99287002952	LysR family transcriptional regulator; Provisional; Region: PRK14997
99287002953	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287002954	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
99287002955	putative effector binding pocket; other site
99287002956	putative dimerization interface [polypeptide binding]; other site
99287002957	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
99287002958	rRNA binding site [nucleotide binding]; other site
99287002959	predicted 30S ribosome binding site; other site
99287002960	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
99287002961	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
99287002962	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99287002963	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
99287002964	Walker A/P-loop; other site
99287002965	ATP binding site [chemical binding]; other site
99287002966	Q-loop/lid; other site
99287002967	ABC transporter signature motif; other site
99287002968	Walker B; other site
99287002969	D-loop; other site
99287002970	H-loop/switch region; other site
99287002971	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
99287002972	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99287002973	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287002974	Walker A/P-loop; other site
99287002975	ATP binding site [chemical binding]; other site
99287002976	Q-loop/lid; other site
99287002977	ABC transporter signature motif; other site
99287002978	Walker B; other site
99287002979	D-loop; other site
99287002980	H-loop/switch region; other site
99287002981	thioredoxin reductase; Provisional; Region: PRK10262
99287002982	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287002983	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99287002984	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
99287002985	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99287002986	putative DNA binding site [nucleotide binding]; other site
99287002987	putative Zn2+ binding site [ion binding]; other site
99287002988	AsnC family; Region: AsnC_trans_reg; pfam01037
99287002989	DNA translocase FtsK; Provisional; Region: PRK10263
99287002990	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287002991	variable surface protein Vir28; Provisional; Region: PTZ00249
99287002992	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
99287002993	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
99287002994	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
99287002995	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192
99287002996	recombination factor protein RarA; Reviewed; Region: PRK13342
99287002997	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287002998	Walker A motif; other site
99287002999	ATP binding site [chemical binding]; other site
99287003000	Walker B motif; other site
99287003001	arginine finger; other site
99287003002	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
99287003003	seryl-tRNA synthetase; Provisional; Region: PRK05431
99287003004	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
99287003005	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
99287003006	dimer interface [polypeptide binding]; other site
99287003007	active site
99287003008	motif 1; other site
99287003009	motif 2; other site
99287003010	motif 3; other site
99287003011	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
99287003012	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
99287003013	putative [Fe4-S4] binding site [ion binding]; other site
99287003014	putative molybdopterin cofactor binding site [chemical binding]; other site
99287003015	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
99287003016	putative molybdopterin cofactor binding site; other site
99287003017	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
99287003018	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287003019	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
99287003020	putative MFS family transporter protein; Provisional; Region: PRK03633
99287003021	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287003022	putative substrate translocation pore; other site
99287003023	inner membrane transporter YjeM; Provisional; Region: PRK15238
99287003024	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
99287003025	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287003026	FeS/SAM binding site; other site
99287003027	integrase; Provisional; Region: int; PHA02601
99287003028	pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380
99287003029	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
99287003030	Pyruvate formate lyase 1; Region: PFL1; cd01678
99287003031	coenzyme A binding site [chemical binding]; other site
99287003032	active site
99287003033	catalytic residues [active]
99287003034	glycine loop; other site
99287003035	formate transporter; Provisional; Region: PRK10805
99287003036	uncharacterized domain; Region: TIGR00702
99287003037	Predicted membrane protein [Function unknown]; Region: COG2323
99287003038	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
99287003039	homodimer interface [polypeptide binding]; other site
99287003040	substrate-cofactor binding pocket; other site
99287003041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287003042	catalytic residue [active]
99287003043	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
99287003044	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
99287003045	putative active site [active]
99287003046	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
99287003047	cytidylate kinase; Provisional; Region: cmk; PRK00023
99287003048	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
99287003049	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
99287003050	active site
99287003051	CMP-binding site; other site
99287003052	The sites determining sugar specificity; other site
99287003053	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
99287003054	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
99287003055	RNA binding site [nucleotide binding]; other site
99287003056	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
99287003057	RNA binding site [nucleotide binding]; other site
99287003058	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
99287003059	RNA binding site [nucleotide binding]; other site
99287003060	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
99287003061	RNA binding site [nucleotide binding]; other site
99287003062	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
99287003063	RNA binding site [nucleotide binding]; other site
99287003064	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
99287003065	RNA binding site [nucleotide binding]; other site
99287003066	Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836
99287003067	dimer interface [polypeptide binding]; other site
99287003068	DNA binding site [nucleotide binding]
99287003069	ComEC family competence protein; Provisional; Region: PRK11539
99287003070	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
99287003071	Competence protein; Region: Competence; pfam03772
99287003072	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
99287003073	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
99287003074	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99287003075	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
99287003076	Walker A/P-loop; other site
99287003077	ATP binding site [chemical binding]; other site
99287003078	Q-loop/lid; other site
99287003079	ABC transporter signature motif; other site
99287003080	Walker B; other site
99287003081	D-loop; other site
99287003082	H-loop/switch region; other site
99287003083	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
99287003084	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
99287003085	hypothetical protein; Provisional; Region: PRK11827
99287003086	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
99287003087	Ligand binding site; other site
99287003088	oligomer interface; other site
99287003089	hypothetical protein; Provisional; Region: PRK10593
99287003090	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
99287003091	putative active site [active]
99287003092	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
99287003093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287003094	S-adenosylmethionine binding site [chemical binding]; other site
99287003095	condesin subunit F; Provisional; Region: PRK05260
99287003096	condesin subunit E; Provisional; Region: PRK05256
99287003097	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
99287003098	P-loop containing region of AAA domain; Region: AAA_29; cl17516
99287003099	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
99287003100	murein L,D-transpeptidase; Provisional; Region: PRK10594
99287003101	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
99287003102	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
99287003103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
99287003104	Peptidase M15; Region: Peptidase_M15_3; cl01194
99287003105	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
99287003106	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
99287003107	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99287003108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287003109	homodimer interface [polypeptide binding]; other site
99287003110	catalytic residue [active]
99287003111	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
99287003112	trimer interface [polypeptide binding]; other site
99287003113	eyelet of channel; other site
99287003114	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
99287003115	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
99287003116	putative dimer interface [polypeptide binding]; other site
99287003117	putative anticodon binding site; other site
99287003118	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
99287003119	homodimer interface [polypeptide binding]; other site
99287003120	motif 1; other site
99287003121	motif 2; other site
99287003122	active site
99287003123	motif 3; other site
99287003124	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
99287003125	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99287003126	putative DNA binding site [nucleotide binding]; other site
99287003127	putative Zn2+ binding site [ion binding]; other site
99287003128	AsnC family; Region: AsnC_trans_reg; pfam01037
99287003129	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
99287003130	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99287003131	catalytic residue [active]
99287003132	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
99287003133	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
99287003134	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
99287003135	active site
99287003136	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
99287003137	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
99287003138	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
99287003139	Int/Topo IB signature motif; other site
99287003140	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
99287003141	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
99287003142	RecT family; Region: RecT; pfam03837
99287003143	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
99287003144	exonuclease VIII; Reviewed; Region: PRK09709
99287003145	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
99287003146	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287003147	non-specific DNA binding site [nucleotide binding]; other site
99287003148	salt bridge; other site
99287003149	sequence-specific DNA binding site [nucleotide binding]; other site
99287003150	Bacteriophage CII protein; Region: Phage_CII; pfam05269
99287003151	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
99287003152	primosomal protein DnaI; Provisional; Region: PRK02854
99287003153	putative replication protein; Provisional; Region: PRK12377
99287003154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287003155	Walker A motif; other site
99287003156	ATP binding site [chemical binding]; other site
99287003157	Walker B motif; other site
99287003158	arginine finger; other site
99287003159	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
99287003160	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
99287003161	DinI-like family; Region: DinI; pfam06183
99287003162	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
99287003163	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
99287003164	Antitermination protein; Region: Antiterm; pfam03589
99287003165	Antitermination protein; Region: Antiterm; pfam03589
99287003166	PipA protein; Region: PipA; pfam07108
99287003167	phage holin, lambda family; Region: holin_lambda; TIGR01594
99287003168	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
99287003169	catalytic residues [active]
99287003170	Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245
99287003171	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
99287003172	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
99287003173	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
99287003174	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
99287003175	oligomer interface [polypeptide binding]; other site
99287003176	active site residues [active]
99287003177	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
99287003178	Uncharacterized conserved protein [Function unknown]; Region: COG5471
99287003179	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856
99287003180	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
99287003181	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
99287003182	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
99287003183	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
99287003184	phage minor tail protein G; Region: phage_lambda_G; TIGR01674
99287003185	phage tail assembly protein T; Region: phage_lam_T; TIGR01715
99287003186	Phage-related minor tail protein [Function unknown]; Region: COG5281
99287003187	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
99287003188	phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541
99287003189	Phage-related protein [Function unknown]; Region: COG4718
99287003190	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
99287003191	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
99287003192	E-class dimer interface [polypeptide binding]; other site
99287003193	P-class dimer interface [polypeptide binding]; other site
99287003194	active site
99287003195	Cu2+ binding site [ion binding]; other site
99287003196	Zn2+ binding site [ion binding]; other site
99287003197	Phage-related protein [Function unknown]; Region: gp18; COG4672
99287003198	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
99287003199	MPN+ (JAMM) motif; other site
99287003200	Zinc-binding site [ion binding]; other site
99287003201	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
99287003202	NlpC/P60 family; Region: NLPC_P60; cl17555
99287003203	Phage-related protein, tail component [Function unknown]; Region: COG4723
99287003204	Phage-related protein, tail component [Function unknown]; Region: COG4733
99287003205	Putative phage tail protein; Region: Phage-tail_3; pfam13550
99287003206	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
99287003207	Interdomain contacts; other site
99287003208	Cytokine receptor motif; other site
99287003209	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
99287003210	Fibronectin type III protein; Region: DUF3672; pfam12421
99287003211	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
99287003212	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
99287003213	Protein of unknown function (DUF1002); Region: DUF1002; cl19854
99287003214	Phage Tail Collar Domain; Region: Collar; pfam07484
99287003215	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
99287003216	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
99287003217	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
99287003218	Dermonecrotoxin of the Papain-like fold; Region: Tox-PLDMTX; pfam15645
99287003219	hypothetical protein; Provisional; Region: PRK09951
99287003220	DinI-like family; Region: DinI; cl11630
99287003221	aminopeptidase N; Provisional; Region: pepN; PRK14015
99287003222	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
99287003223	active site
99287003224	Zn binding site [ion binding]; other site
99287003225	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
99287003226	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
99287003227	quinone interaction residues [chemical binding]; other site
99287003228	active site
99287003229	catalytic residues [active]
99287003230	FMN binding site [chemical binding]; other site
99287003231	substrate binding site [chemical binding]; other site
99287003232	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
99287003233	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
99287003234	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
99287003235	MOSC domain; Region: MOSC; pfam03473
99287003236	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99287003237	catalytic loop [active]
99287003238	iron binding site [ion binding]; other site
99287003239	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
99287003240	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
99287003241	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
99287003242	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287003243	S-adenosylmethionine binding site [chemical binding]; other site
99287003244	ABC transporter ATPase component; Reviewed; Region: PRK11147
99287003245	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
99287003246	ABC transporter; Region: ABC_tran_2; pfam12848
99287003247	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
99287003248	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
99287003249	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
99287003250	Paraquat-inducible protein A; Region: PqiA; pfam04403
99287003251	Paraquat-inducible protein A; Region: PqiA; pfam04403
99287003252	paraquat-inducible protein B; Provisional; Region: PRK10807
99287003253	mce related protein; Region: MCE; pfam02470
99287003254	mce related protein; Region: MCE; pfam02470
99287003255	mce related protein; Region: MCE; pfam02470
99287003256	Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046
99287003257	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
99287003258	ribosome modulation factor; Provisional; Region: PRK14563
99287003259	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
99287003260	active site 1 [active]
99287003261	dimer interface [polypeptide binding]; other site
99287003262	active site 2 [active]
99287003263	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
99287003264	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
99287003265	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
99287003266	outer membrane protein A; Reviewed; Region: PRK10808
99287003267	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
99287003268	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
99287003269	ligand binding site [chemical binding]; other site
99287003270	cell division inhibitor SulA; Region: sula; TIGR00623
99287003271	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
99287003272	TfoX C-terminal domain; Region: TfoX_C; pfam04994
99287003273	TIGR01666 family membrane protein; Region: YCCS
99287003274	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
99287003275	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
99287003276	Predicted membrane protein [Function unknown]; Region: COG3304
99287003277	Domain of unknown function (DUF307); Region: DUF307; pfam03733
99287003278	Domain of unknown function (DUF307); Region: DUF307; pfam03733
99287003279	DNA helicase IV; Provisional; Region: helD; PRK11054
99287003280	DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462
99287003281	Part of AAA domain; Region: AAA_19; pfam13245
99287003282	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
99287003283	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
99287003284	active site
99287003285	dimer interfaces [polypeptide binding]; other site
99287003286	catalytic residues [active]
99287003287	hypothetical protein; Provisional; Region: PRK03641
99287003288	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
99287003289	heat shock protein HspQ; Provisional; Region: PRK14129
99287003290	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
99287003291	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
99287003292	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
99287003293	putative RNA binding site [nucleotide binding]; other site
99287003294	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287003295	S-adenosylmethionine binding site [chemical binding]; other site
99287003296	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
99287003297	substrate binding site [chemical binding]; other site
99287003298	Cupin domain; Region: Cupin_2; cl17218
99287003299	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99287003300	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287003301	acylphosphatase; Provisional; Region: PRK14426
99287003302	sulfur transfer protein TusE; Provisional; Region: PRK11508
99287003303	YccA-like proteins; Region: YccA_like; cd10433
99287003304	SPI-5; Salmonella pathogenicity island 5; similar to sequence found in GenBank Accession Number AF060858; important for enteropathogenicity
99287003305	PipA protein; Region: PipA; pfam07108
99287003306	secreted effector protein PipB; Provisional; Region: PRK15197
99287003307	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99287003308	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99287003309	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99287003310	type III secretion chaperone protein SigE; Provisional; Region: PRK15202
99287003311	Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925
99287003312	Domain of unknown function (DUF3950); Region: DUF3950; pfam13132
99287003313	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
99287003314	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
99287003315	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287003316	dimerization interface [polypeptide binding]; other site
99287003317	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287003318	dimer interface [polypeptide binding]; other site
99287003319	phosphorylation site [posttranslational modification]
99287003320	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287003321	ATP binding site [chemical binding]; other site
99287003322	Mg2+ binding site [ion binding]; other site
99287003323	G-X-G motif; other site
99287003324	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
99287003325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287003326	active site
99287003327	phosphorylation site [posttranslational modification]
99287003328	intermolecular recognition site; other site
99287003329	dimerization interface [polypeptide binding]; other site
99287003330	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287003331	DNA binding site [nucleotide binding]
99287003332	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
99287003333	active site
99287003334	homotetramer interface [polypeptide binding]; other site
99287003335	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
99287003336	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
99287003337	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
99287003338	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
99287003339	Transcriptional regulators [Transcription]; Region: MarR; COG1846
99287003340	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203
99287003341	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
99287003342	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
99287003343	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
99287003344	NAD binding site [chemical binding]; other site
99287003345	catalytic residues [active]
99287003346	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
99287003347	putative active site [active]
99287003348	putative metal binding site [ion binding]; other site
99287003349	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
99287003350	putative substrate binding pocket [chemical binding]; other site
99287003351	trimer interface [polypeptide binding]; other site
99287003352	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
99287003353	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311
99287003354	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
99287003355	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287003356	putative substrate translocation pore; other site
99287003357	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
99287003358	Cupin domain; Region: Cupin_2; pfam07883
99287003359	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287003360	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
99287003361	anti-adapter protein IraM; Provisional; Region: PRK09919
99287003362	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
99287003363	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
99287003364	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99287003365	HSP70 interaction site [polypeptide binding]; other site
99287003366	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
99287003367	substrate binding site [polypeptide binding]; other site
99287003368	dimer interface [polypeptide binding]; other site
99287003369	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
99287003370	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
99287003371	Sulfite exporter TauE/SafE; Region: TauE; cl19196
99287003372	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
99287003373	DsbD alpha interface [polypeptide binding]; other site
99287003374	catalytic residues [active]
99287003375	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
99287003376	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
99287003377	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
99287003378	catalytic residues [active]
99287003379	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
99287003380	catalytic residues [active]
99287003381	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
99287003382	catalytic core [active]
99287003383	hypothetical protein; Provisional; Region: PRK10174
99287003384	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
99287003385	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
99287003386	General stress protein [General function prediction only]; Region: GsiB; COG3729
99287003387	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
99287003388	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287003389	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
99287003390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
99287003391	bifunctional PutA protein; bifunctional in plasma membrane proline dehydrogenase and pyrroline-5-carboxylate dehydrogenase OR in cytoplasm a transcriptional repressor; contains frameshifts
99287003392	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
99287003393	Na binding site [ion binding]; other site
99287003394	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
99287003395	hypothetical protein; Provisional; Region: PRK10536
99287003396	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
99287003397	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
99287003398	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
99287003399	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
99287003400	putative active site [active]
99287003401	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
99287003402	Na binding site [ion binding]; other site
99287003403	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
99287003404	putative active site cavity [active]
99287003405	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
99287003406	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
99287003407	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
99287003408	putative sialic acid transporter; Provisional; Region: PRK12307
99287003409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287003410	putative substrate translocation pore; other site
99287003411	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
99287003412	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99287003413	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
99287003414	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
99287003415	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
99287003416	putative ligand binding site [chemical binding]; other site
99287003417	NAD binding site [chemical binding]; other site
99287003418	dimerization interface [polypeptide binding]; other site
99287003419	catalytic site [active]
99287003420	putative hydrolase; Validated; Region: PRK09248
99287003421	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
99287003422	active site
99287003423	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
99287003424	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
99287003425	curli production assembly/transport protein CsgG; Provisional; Region: PRK15184
99287003426	curli assembly protein CsgF; Provisional; Region: PRK10050
99287003427	curli assembly protein CsgE; Provisional; Region: PRK10386
99287003428	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
99287003429	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287003430	DNA binding residues [nucleotide binding]
99287003431	dimerization interface [polypeptide binding]; other site
99287003432	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
99287003433	Curlin associated repeat; Region: Curlin_rpt; pfam07012
99287003434	Curlin associated repeat; Region: Curlin_rpt; pfam07012
99287003435	major curlin subunit; Provisional; Region: csgA; PRK10051
99287003436	curli assembly protein CsgC; Provisional; Region: csgC; PRK10102
99287003437	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
99287003438	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
99287003439	putative ADP-ribose binding site [chemical binding]; other site
99287003440	putative active site [active]
99287003441	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
99287003442	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
99287003443	putative active site [active]
99287003444	catalytic site [active]
99287003445	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
99287003446	putative active site [active]
99287003447	catalytic site [active]
99287003448	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
99287003449	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
99287003450	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
99287003451	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
99287003452	Ligand binding site; other site
99287003453	DXD motif; other site
99287003454	lipoprotein; Provisional; Region: PRK10175
99287003455	secY/secA suppressor protein; Provisional; Region: PRK11467
99287003456	drug efflux system protein MdtG; Provisional; Region: PRK09874
99287003457	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287003458	putative substrate translocation pore; other site
99287003459	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
99287003460	putative acyl-acceptor binding pocket; other site
99287003461	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
99287003462	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
99287003463	active site residue [active]
99287003464	hypothetical protein; Provisional; Region: PRK03757
99287003465	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
99287003466	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
99287003467	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
99287003468	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
99287003469	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
99287003470	DNA damage-inducible protein I; Provisional; Region: PRK10597
99287003471	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
99287003472	active site
99287003473	substrate binding pocket [chemical binding]; other site
99287003474	dimer interface [polypeptide binding]; other site
99287003475	lipoprotein; Provisional; Region: PRK10598
99287003476	glutaredoxin 2; Provisional; Region: PRK10387
99287003477	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
99287003478	C-terminal domain interface [polypeptide binding]; other site
99287003479	GSH binding site (G-site) [chemical binding]; other site
99287003480	catalytic residues [active]
99287003481	putative dimer interface [polypeptide binding]; other site
99287003482	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
99287003483	N-terminal domain interface [polypeptide binding]; other site
99287003484	multidrug resistance protein MdtH; Provisional; Region: PRK11646
99287003485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287003486	putative substrate translocation pore; other site
99287003487	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
99287003488	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
99287003489	hypothetical protein; Provisional; Region: PRK11239
99287003490	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
99287003491	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99287003492	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
99287003493	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
99287003494	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
99287003495	flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459
99287003496	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
99287003497	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
99287003498	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
99287003499	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
99287003500	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
99287003501	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
99287003502	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
99287003503	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
99287003504	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
99287003505	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
99287003506	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
99287003507	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
99287003508	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
99287003509	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
99287003510	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
99287003511	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
99287003512	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
99287003513	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
99287003514	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694
99287003515	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
99287003516	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
99287003517	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
99287003518	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
99287003519	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
99287003520	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
99287003521	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
99287003522	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
99287003523	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
99287003524	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
99287003525	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
99287003526	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
99287003527	ribonuclease E; Reviewed; Region: rne; PRK10811
99287003528	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
99287003529	homodimer interface [polypeptide binding]; other site
99287003530	oligonucleotide binding site [chemical binding]; other site
99287003531	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
99287003532	Protein of unknown function (DUF3157); Region: DUF3157; pfam11355
99287003533	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
99287003534	Protein of unknown function (DUF2655); Region: DUF2655; pfam10848
99287003535	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
99287003536	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99287003537	RNA binding surface [nucleotide binding]; other site
99287003538	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
99287003539	active site
99287003540	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
99287003541	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
99287003542	active site
99287003543	dimer interface [polypeptide binding]; other site
99287003544	hypothetical protein; Provisional; Region: PRK11193
99287003545	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
99287003546	putative phosphate acyltransferase; Provisional; Region: PRK05331
99287003547	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
99287003548	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
99287003549	dimer interface [polypeptide binding]; other site
99287003550	active site
99287003551	CoA binding pocket [chemical binding]; other site
99287003552	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
99287003553	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
99287003554	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
99287003555	NAD(P) binding site [chemical binding]; other site
99287003556	homotetramer interface [polypeptide binding]; other site
99287003557	homodimer interface [polypeptide binding]; other site
99287003558	active site
99287003559	acyl carrier protein; Provisional; Region: acpP; PRK00982
99287003560	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
99287003561	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
99287003562	dimer interface [polypeptide binding]; other site
99287003563	active site
99287003564	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
99287003565	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287003566	catalytic residue [active]
99287003567	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
99287003568	dimerization interface [polypeptide binding]; other site
99287003569	thymidylate kinase; Validated; Region: tmk; PRK00698
99287003570	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
99287003571	TMP-binding site; other site
99287003572	ATP-binding site [chemical binding]; other site
99287003573	DNA polymerase III subunit delta'; Validated; Region: PRK07993
99287003574	DNA polymerase III subunit delta'; Validated; Region: PRK08485
99287003575	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
99287003576	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
99287003577	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
99287003578	active site
99287003579	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
99287003580	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
99287003581	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
99287003582	active site turn [active]
99287003583	phosphorylation site [posttranslational modification]
99287003584	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
99287003585	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99287003586	N-terminal plug; other site
99287003587	ligand-binding site [chemical binding]; other site
99287003588	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
99287003589	nucleotide binding site/active site [active]
99287003590	HIT family signature motif; other site
99287003591	catalytic residue [active]
99287003592	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
99287003593	putative dimer interface [polypeptide binding]; other site
99287003594	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
99287003595	Phosphotransferase enzyme family; Region: APH; pfam01636
99287003596	active site
99287003597	ATP binding site [chemical binding]; other site
99287003598	thiamine kinase; Provisional; Region: thiK; PRK10271
99287003599	substrate binding site [chemical binding]; other site
99287003600	beta-hexosaminidase; Provisional; Region: PRK05337
99287003601	hypothetical protein; Provisional; Region: PRK04940
99287003602	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
99287003603	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99287003604	hypothetical protein; Provisional; Region: PRK11280
99287003605	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99287003606	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287003607	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cl00532
99287003608	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
99287003609	L,D-transpeptidase; Provisional; Region: PRK10260
99287003610	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
99287003611	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
99287003612	transcription-repair coupling factor; Provisional; Region: PRK10689
99287003613	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
99287003614	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
99287003615	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99287003616	ATP binding site [chemical binding]; other site
99287003617	putative Mg++ binding site [ion binding]; other site
99287003618	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287003619	nucleotide binding region [chemical binding]; other site
99287003620	ATP-binding site [chemical binding]; other site
99287003621	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
99287003622	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
99287003623	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99287003624	FtsX-like permease family; Region: FtsX; pfam02687
99287003625	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
99287003626	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
99287003627	Walker A/P-loop; other site
99287003628	ATP binding site [chemical binding]; other site
99287003629	Q-loop/lid; other site
99287003630	ABC transporter signature motif; other site
99287003631	Walker B; other site
99287003632	D-loop; other site
99287003633	H-loop/switch region; other site
99287003634	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
99287003635	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
99287003636	FtsX-like permease family; Region: FtsX; pfam02687
99287003637	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
99287003638	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99287003639	nucleotide binding site [chemical binding]; other site
99287003640	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
99287003641	NAD+ binding site [chemical binding]; other site
99287003642	substrate binding site [chemical binding]; other site
99287003643	Zn binding site [ion binding]; other site
99287003644	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
99287003645	spermidine/putrescine ABC transporter membrane protein; Reviewed; Region: potC; PRK09500
99287003646	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287003647	dimer interface [polypeptide binding]; other site
99287003648	conserved gate region; other site
99287003649	putative PBP binding loops; other site
99287003650	ABC-ATPase subunit interface; other site
99287003651	secreted effector protein SifA; Reviewed; Region: sifA; PRK09498
99287003652	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
99287003653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287003654	dimer interface [polypeptide binding]; other site
99287003655	conserved gate region; other site
99287003656	putative PBP binding loops; other site
99287003657	ABC-ATPase subunit interface; other site
99287003658	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
99287003659	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
99287003660	Walker A/P-loop; other site
99287003661	ATP binding site [chemical binding]; other site
99287003662	Q-loop/lid; other site
99287003663	ABC transporter signature motif; other site
99287003664	Walker B; other site
99287003665	D-loop; other site
99287003666	H-loop/switch region; other site
99287003667	TOBE domain; Region: TOBE_2; pfam08402
99287003668	peptidase T-like protein; Region: PepT-like; TIGR01883
99287003669	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
99287003670	metal binding site [ion binding]; metal-binding site
99287003671	dimer interface [polypeptide binding]; other site
99287003672	Uncharacterized conserved protein [Function unknown]; Region: COG2850
99287003673	sensor protein PhoQ; Provisional; Region: PRK10815
99287003674	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
99287003675	HAMP domain; Region: HAMP; pfam00672
99287003676	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
99287003677	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287003678	ATP binding site [chemical binding]; other site
99287003679	Mg2+ binding site [ion binding]; other site
99287003680	G-X-G motif; other site
99287003681	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
99287003682	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287003683	active site
99287003684	phosphorylation site [posttranslational modification]
99287003685	intermolecular recognition site; other site
99287003686	dimerization interface [polypeptide binding]; other site
99287003687	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287003688	DNA binding site [nucleotide binding]
99287003689	adenylosuccinate lyase; Provisional; Region: PRK09285
99287003690	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
99287003691	tetramer interface [polypeptide binding]; other site
99287003692	active site
99287003693	putative lysogenization regulator; Reviewed; Region: PRK00218
99287003694	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
99287003695	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
99287003696	Ligand Binding Site [chemical binding]; other site
99287003697	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
99287003698	nudix motif; other site
99287003699	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
99287003700	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
99287003701	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
99287003702	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
99287003703	probable active site [active]
99287003704	isocitrate dehydrogenase; Reviewed; Region: PRK07006
99287003705	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
99287003706	fragment of transposase
99287003707	DinI-like family; Region: DinI; pfam06183
99287003708	Ricin-type beta-trefoil; Region: RICIN; smart00458
99287003709	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
99287003710	putative sugar binding sites [chemical binding]; other site
99287003711	Q-X-W motif; other site
99287003712	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
99287003713	DNA-binding site [nucleotide binding]; DNA binding site
99287003714	RNA-binding motif; other site
99287003715	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
99287003716	lysozyme inhibitor; Provisional; Region: PRK13791
99287003717	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
99287003718	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
99287003719	putative dimer interface [polypeptide binding]; other site
99287003720	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
99287003721	BNR repeat-like domain; Region: BNR_2; pfam13088
99287003722	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
99287003723	TRL-like protein family; Region: TRL; pfam13146
99287003724	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
99287003725	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
99287003726	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
99287003727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287003728	dimer interface [polypeptide binding]; other site
99287003729	conserved gate region; other site
99287003730	putative PBP binding loops; other site
99287003731	ABC-ATPase subunit interface; other site
99287003732	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
99287003733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287003734	dimer interface [polypeptide binding]; other site
99287003735	conserved gate region; other site
99287003736	putative PBP binding loops; other site
99287003737	ABC-ATPase subunit interface; other site
99287003738	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287003739	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
99287003740	Walker A/P-loop; other site
99287003741	ATP binding site [chemical binding]; other site
99287003742	Q-loop/lid; other site
99287003743	ABC transporter signature motif; other site
99287003744	Walker B; other site
99287003745	D-loop; other site
99287003746	H-loop/switch region; other site
99287003747	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287003748	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
99287003749	Walker A/P-loop; other site
99287003750	ATP binding site [chemical binding]; other site
99287003751	Q-loop/lid; other site
99287003752	ABC transporter signature motif; other site
99287003753	Walker B; other site
99287003754	D-loop; other site
99287003755	H-loop/switch region; other site
99287003756	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
99287003757	Mechanosensitive ion channel; Region: MS_channel; pfam00924
99287003758	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
99287003759	dimerization interface [polypeptide binding]; other site
99287003760	zinc/cadmium-binding protein; Provisional; Region: PRK10306
99287003761	aminoglycoside resistance protein; Provisional; Region: PRK13746
99287003762	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
99287003763	active site
99287003764	NTP binding site [chemical binding]; other site
99287003765	metal binding triad [ion binding]; metal-binding site
99287003766	antibiotic binding site [chemical binding]; other site
99287003767	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
99287003768	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
99287003769	DNA binding residues [nucleotide binding]
99287003770	transcriptional regulator MirA; Provisional; Region: PRK15043
99287003771	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
99287003772	DNA binding residues [nucleotide binding]
99287003773	dimer interface [polypeptide binding]; other site
99287003774	Pleckstrin homology-like domain; Region: PH-like; cl17171
99287003775	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
99287003776	chorismate mutase; Provisional; Region: PRK08055
99287003777	leucine export protein LeuE; Provisional; Region: PRK10958
99287003778	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
99287003779	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
99287003780	hypothetical protein; Provisional; Region: PRK10457
99287003781	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
99287003782	Uncharacterized conserved protein [Function unknown]; Region: COG3189
99287003783	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
99287003784	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287003785	putative substrate translocation pore; other site
99287003786	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
99287003787	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
99287003788	Predicted membrane protein [Function unknown]; Region: COG2707
99287003789	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
99287003790	putative deacylase active site [active]
99287003791	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99287003792	metal binding site [ion binding]; metal-binding site
99287003793	active site
99287003794	I-site; other site
99287003795	hypothetical protein; Provisional; Region: PRK05325
99287003796	PrkA family serine protein kinase; Provisional; Region: PRK15455
99287003797	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287003798	Walker A motif; other site
99287003799	ATP binding site [chemical binding]; other site
99287003800	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
99287003801	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
99287003802	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
99287003803	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287003804	FeS/SAM binding site; other site
99287003805	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
99287003806	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99287003807	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
99287003808	active site
99287003809	catalytic tetrad [active]
99287003810	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
99287003811	active site
99287003812	phosphate binding residues; other site
99287003813	catalytic residues [active]
99287003814	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
99287003815	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
99287003816	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
99287003817	methionine sulfoxide reductase B; Provisional; Region: PRK00222
99287003818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
99287003819	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
99287003820	catalytic triad [active]
99287003821	metal binding site [ion binding]; metal-binding site
99287003822	conserved cis-peptide bond; other site
99287003823	cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461
99287003824	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
99287003825	active site
99287003826	homodimer interface [polypeptide binding]; other site
99287003827	protease 4; Provisional; Region: PRK10949
99287003828	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
99287003829	tandem repeat interface [polypeptide binding]; other site
99287003830	oligomer interface [polypeptide binding]; other site
99287003831	active site residues [active]
99287003832	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
99287003833	tandem repeat interface [polypeptide binding]; other site
99287003834	oligomer interface [polypeptide binding]; other site
99287003835	active site residues [active]
99287003836	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
99287003837	putative FMN binding site [chemical binding]; other site
99287003838	selenophosphate synthetase; Provisional; Region: PRK00943
99287003839	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
99287003840	dimerization interface [polypeptide binding]; other site
99287003841	putative ATP binding site [chemical binding]; other site
99287003842	DNA topoisomerase III; Provisional; Region: PRK07726
99287003843	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
99287003844	active site
99287003845	putative interdomain interaction site [polypeptide binding]; other site
99287003846	putative metal-binding site [ion binding]; other site
99287003847	putative nucleotide binding site [chemical binding]; other site
99287003848	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
99287003849	domain I; other site
99287003850	DNA binding groove [nucleotide binding]
99287003851	phosphate binding site [ion binding]; other site
99287003852	domain II; other site
99287003853	domain III; other site
99287003854	nucleotide binding site [chemical binding]; other site
99287003855	catalytic site [active]
99287003856	domain IV; other site
99287003857	glutamate dehydrogenase; Provisional; Region: PRK09414
99287003858	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
99287003859	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
99287003860	NAD(P) binding site [chemical binding]; other site
99287003861	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
99287003862	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
99287003863	active site
99287003864	8-oxo-dGMP binding site [chemical binding]; other site
99287003865	nudix motif; other site
99287003866	metal binding site [ion binding]; metal-binding site
99287003867	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
99287003868	putative catalytic site [active]
99287003869	putative phosphate binding site [ion binding]; other site
99287003870	active site
99287003871	metal binding site A [ion binding]; metal-binding site
99287003872	DNA binding site [nucleotide binding]
99287003873	putative AP binding site [nucleotide binding]; other site
99287003874	putative metal binding site B [ion binding]; other site
99287003875	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
99287003876	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
99287003877	inhibitor-cofactor binding pocket; inhibition site
99287003878	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287003879	catalytic residue [active]
99287003880	arginine succinyltransferase; Provisional; Region: PRK10456
99287003881	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
99287003882	NAD(P) binding site [chemical binding]; other site
99287003883	catalytic residues [active]
99287003884	succinylarginine dihydrolase; Provisional; Region: PRK13281
99287003885	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
99287003886	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
99287003887	putative active site [active]
99287003888	Zn binding site [ion binding]; other site
99287003889	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
99287003890	dimer interface [polypeptide binding]; other site
99287003891	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
99287003892	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
99287003893	GIY-YIG motif/motif A; other site
99287003894	active site
99287003895	catalytic site [active]
99287003896	putative DNA binding site [nucleotide binding]; other site
99287003897	metal binding site [ion binding]; metal-binding site
99287003898	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
99287003899	homodimer interface [polypeptide binding]; other site
99287003900	NAD binding pocket [chemical binding]; other site
99287003901	ATP binding pocket [chemical binding]; other site
99287003902	Mg binding site [ion binding]; other site
99287003903	active-site loop [active]
99287003904	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
99287003905	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
99287003906	active site
99287003907	P-loop; other site
99287003908	phosphorylation site [posttranslational modification]
99287003909	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
99287003910	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
99287003911	methionine cluster; other site
99287003912	active site
99287003913	phosphorylation site [posttranslational modification]
99287003914	metal binding site [ion binding]; metal-binding site
99287003915	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
99287003916	Cupin domain; Region: Cupin_2; cl17218
99287003917	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287003918	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
99287003919	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
99287003920	NAD binding site [chemical binding]; other site
99287003921	sugar binding site [chemical binding]; other site
99287003922	divalent metal binding site [ion binding]; other site
99287003923	tetramer (dimer of dimers) interface [polypeptide binding]; other site
99287003924	dimer interface [polypeptide binding]; other site
99287003925	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
99287003926	putative active site [active]
99287003927	YdjC motif; other site
99287003928	Mg binding site [ion binding]; other site
99287003929	putative homodimer interface [polypeptide binding]; other site
99287003930	hydroperoxidase II; Provisional; Region: katE; PRK11249
99287003931	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
99287003932	tetramer interface [polypeptide binding]; other site
99287003933	heme binding pocket [chemical binding]; other site
99287003934	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
99287003935	domain interactions; other site
99287003936	cell division modulator; Provisional; Region: PRK10113
99287003937	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
99287003938	inner membrane protein; Provisional; Region: PRK11648
99287003939	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
99287003940	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
99287003941	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287003942	motif II; other site
99287003943	YniB-like protein; Region: YniB; pfam14002
99287003944	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001
99287003945	Phosphotransferase enzyme family; Region: APH; pfam01636
99287003946	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
99287003947	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
99287003948	putative substrate binding site [chemical binding]; other site
99287003949	putative ATP binding site [chemical binding]; other site
99287003950	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
99287003951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528
99287003952	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
99287003953	active site
99287003954	substrate binding site [chemical binding]; other site
99287003955	Mg2+ binding site [ion binding]; other site
99287003956	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
99287003957	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
99287003958	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
99287003959	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
99287003960	active site
99287003961	dimer interface [polypeptide binding]; other site
99287003962	motif 1; other site
99287003963	motif 2; other site
99287003964	motif 3; other site
99287003965	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
99287003966	anticodon binding site; other site
99287003967	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
99287003968	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
99287003969	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
99287003970	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
99287003971	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
99287003972	23S rRNA binding site [nucleotide binding]; other site
99287003973	L21 binding site [polypeptide binding]; other site
99287003974	L13 binding site [polypeptide binding]; other site
99287003975	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
99287003976	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
99287003977	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
99287003978	dimer interface [polypeptide binding]; other site
99287003979	motif 1; other site
99287003980	active site
99287003981	motif 2; other site
99287003982	motif 3; other site
99287003983	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
99287003984	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
99287003985	putative tRNA-binding site [nucleotide binding]; other site
99287003986	B3/4 domain; Region: B3_4; pfam03483
99287003987	tRNA synthetase B5 domain; Region: B5; smart00874
99287003988	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
99287003989	dimer interface [polypeptide binding]; other site
99287003990	motif 1; other site
99287003991	motif 3; other site
99287003992	motif 2; other site
99287003993	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
99287003994	Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835
99287003995	DNA binding site [nucleotide binding]
99287003996	dimer interface [polypeptide binding]; other site
99287003997	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
99287003998	ABC-ATPase subunit  interface; other site
99287003999	dimer interface [polypeptide binding]; other site
99287004000	putative PBP binding regions; other site
99287004001	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
99287004002	catalytic residues [active]
99287004003	dimer interface [polypeptide binding]; other site
99287004004	ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138
99287004005	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
99287004006	Walker A/P-loop; other site
99287004007	ATP binding site [chemical binding]; other site
99287004008	Q-loop/lid; other site
99287004009	ABC transporter signature motif; other site
99287004010	Walker B; other site
99287004011	D-loop; other site
99287004012	H-loop/switch region; other site
99287004013	NlpC/P60 family; Region: NLPC_P60; pfam00877
99287004014	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
99287004015	hypothetical protein; Validated; Region: PRK00029
99287004016	hypothetical protein; Provisional; Region: PRK10183
99287004017	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
99287004018	PEP synthetase regulatory protein; Provisional; Region: PRK05339
99287004019	phosphoenolpyruvate synthase; Validated; Region: PRK06464
99287004020	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
99287004021	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
99287004022	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
99287004023	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
99287004024	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
99287004025	acyl-activating enzyme (AAE) consensus motif; other site
99287004026	putative AMP binding site [chemical binding]; other site
99287004027	putative active site [active]
99287004028	putative CoA binding site [chemical binding]; other site
99287004029	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
99287004030	oxidoreductase; Provisional; Region: PRK10015
99287004031	putative oxidoreductase FixC; Provisional; Region: PRK10157
99287004032	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
99287004033	Electron transfer flavoprotein domain; Region: ETF; pfam01012
99287004034	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
99287004035	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
99287004036	Ligand binding site [chemical binding]; other site
99287004037	Cupin domain; Region: Cupin_2; pfam07883
99287004038	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99287004039	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
99287004040	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
99287004041	active site
99287004042	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
99287004043	Coenzyme A transferase; Region: CoA_trans; smart00882
99287004044	Coenzyme A transferase; Region: CoA_trans; cl17247
99287004045	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
99287004046	active site
99287004047	catalytic residue [active]
99287004048	dimer interface [polypeptide binding]; other site
99287004049	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
99287004050	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
99287004051	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
99287004052	shikimate binding site; other site
99287004053	NAD(P) binding site [chemical binding]; other site
99287004054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287004055	putative transporter; Provisional; Region: PRK03699
99287004056	putative substrate translocation pore; other site
99287004057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287004058	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99287004059	putative substrate translocation pore; other site
99287004060	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
99287004061	putative inner membrane protein; Provisional; Region: PRK10983
99287004062	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
99287004063	FAD binding domain; Region: FAD_binding_4; pfam01565
99287004064	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
99287004065	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
99287004066	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
99287004067	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
99287004068	CoenzymeA binding site [chemical binding]; other site
99287004069	subunit interaction site [polypeptide binding]; other site
99287004070	PHB binding site; other site
99287004071	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
99287004072	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
99287004073	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
99287004074	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
99287004075	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
99287004076	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
99287004077	Walker A/P-loop; other site
99287004078	ATP binding site [chemical binding]; other site
99287004079	Q-loop/lid; other site
99287004080	ABC transporter signature motif; other site
99287004081	Walker B; other site
99287004082	D-loop; other site
99287004083	H-loop/switch region; other site
99287004084	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
99287004085	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
99287004086	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
99287004087	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99287004088	catalytic residue [active]
99287004089	cysteine desufuration protein SufE; Provisional; Region: PRK09296
99287004090	L,D-transpeptidase; Provisional; Region: PRK10260
99287004091	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
99287004092	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
99287004093	murein lipoprotein; Provisional; Region: PRK15396
99287004094	murein lipoprotein; Provisional; Region: PRK15396
99287004095	pyruvate kinase; Provisional; Region: PRK09206
99287004096	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
99287004097	domain interfaces; other site
99287004098	active site
99287004099	SPI-2; Salmonella pathogenicity island 2; encodes a type III secretion system distinct from SPI-1; required for systemic infection and intracellular pathogenesis by facilitating replication of intracellular bacteria within membrane-bound Salmonella-containing vacuoles; not all genes in the island are required for pathogenesis
99287004100	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
99287004101	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
99287004102	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
99287004103	Putative lysophospholipase; Region: Hydrolase_4; cl19140
99287004104	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
99287004105	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
99287004106	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
99287004107	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
99287004108	substrate binding site [chemical binding]; other site
99287004109	dimer interface [polypeptide binding]; other site
99287004110	ATP binding site [chemical binding]; other site
99287004111	tetrathionate reductase subunit A; Provisional; Region: PRK14991
99287004112	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
99287004113	putative [Fe4-S4] binding site [ion binding]; other site
99287004114	putative molybdopterin cofactor binding site [chemical binding]; other site
99287004115	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
99287004116	putative molybdopterin cofactor binding site; other site
99287004117	tetrathionate reductase subunit C; Provisional; Region: PRK14992
99287004118	tetrathionate reductase subunit B; Provisional; Region: PRK14993
99287004119	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287004120	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
99287004121	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99287004122	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287004123	dimer interface [polypeptide binding]; other site
99287004124	phosphorylation site [posttranslational modification]
99287004125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287004126	ATP binding site [chemical binding]; other site
99287004127	Mg2+ binding site [ion binding]; other site
99287004128	G-X-G motif; other site
99287004129	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
99287004130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287004131	active site
99287004132	phosphorylation site [posttranslational modification]
99287004133	intermolecular recognition site; other site
99287004134	dimerization interface [polypeptide binding]; other site
99287004135	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287004136	DNA binding residues [nucleotide binding]
99287004137	dimerization interface [polypeptide binding]; other site
99287004138	hypothetical protein; Provisional; Region: PRK10292
99287004139	Uncharacterized conserved protein [Function unknown]; Region: COG1683
99287004140	Uncharacterized conserved protein [Function unknown]; Region: COG3272
99287004141	transcriptional regulator MirA; Provisional; Region: PRK15043
99287004142	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
99287004143	DNA binding residues [nucleotide binding]
99287004144	two component system sensor kinase SsrB; Provisional; Region: PRK15369
99287004145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287004146	active site
99287004147	phosphorylation site [posttranslational modification]
99287004148	intermolecular recognition site; other site
99287004149	dimerization interface [polypeptide binding]; other site
99287004150	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287004151	DNA binding residues [nucleotide binding]
99287004152	dimerization interface [polypeptide binding]; other site
99287004153	two component system sensor kinase SsrA; Provisional; Region: PRK15347
99287004154	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287004155	dimerization interface [polypeptide binding]; other site
99287004156	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287004157	dimer interface [polypeptide binding]; other site
99287004158	phosphorylation site [posttranslational modification]
99287004159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287004160	ATP binding site [chemical binding]; other site
99287004161	Mg2+ binding site [ion binding]; other site
99287004162	G-X-G motif; other site
99287004163	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287004164	active site
99287004165	phosphorylation site [posttranslational modification]
99287004166	intermolecular recognition site; other site
99287004167	dimerization interface [polypeptide binding]; other site
99287004168	pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368
99287004169	outer membrane secretin SsaC; Provisional; Region: PRK15346
99287004170	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
99287004171	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
99287004172	type III secretion system protein SsaD; Provisional; Region: PRK15367
99287004173	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
99287004174	type III secretion system chaperone SsaE; Provisional; Region: PRK15366
99287004175	type III secretion system chaperone SseA; Provisional; Region: PRK15365
99287004176	pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364
99287004177	pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363
99287004178	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
99287004179	Secretion system effector C (SseC) like family; Region: SseC; pfam04888
99287004180	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
99287004181	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
99287004182	type III secretion system chaperone protein SscB; Provisional; Region: PRK15359
99287004183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287004184	TPR motif; other site
99287004185	binding surface
99287004186	pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358
99287004187	pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357
99287004188	type III secretion system needle protein SsaG; Provisional; Region: PRK15344
99287004189	type III secretion system protein SsaH; Provisional; Region: PRK15356
99287004190	type III secretion system protein SsaI; Provisional; Region: PRK15355
99287004191	type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348
99287004192	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
99287004193	type III secretion system protein SsaK; Provisional; Region: PRK15354
99287004194	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
99287004195	type III secretion system protein SsaL; Provisional; Region: PRK15345
99287004196	HrpJ-like domain; Region: HrpJ; pfam07201
99287004197	TyeA; Region: TyeA; cl07611
99287004198	type III secretion system protein SsaM; Provisional; Region: PRK15353
99287004199	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
99287004200	type III secretion system ATPase SsaN; Validated; Region: PRK07594
99287004201	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
99287004202	Walker A motif/ATP binding site; other site
99287004203	Walker B motif; other site
99287004204	type III secretion system protein SsaO; Provisional; Region: PRK15352
99287004205	type III secretion system protein SsaP; Provisional; Region: PRK15351
99287004206	type III secretion system protein SsaQ; Validated; Region: PRK08035
99287004207	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
99287004208	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
99287004209	Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790
99287004210	type III secretion system protein SsaS; Provisional; Region: PRK15350
99287004211	type III secretion system protein SsaT; Provisional; Region: PRK15349
99287004212	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
99287004213	multidrug efflux protein; Reviewed; Region: PRK01766
99287004214	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
99287004215	cation binding site [ion binding]; other site
99287004216	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
99287004217	Lumazine binding domain; Region: Lum_binding; pfam00677
99287004218	Lumazine binding domain; Region: Lum_binding; pfam00677
99287004219	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
99287004220	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287004221	S-adenosylmethionine binding site [chemical binding]; other site
99287004222	putative transporter; Provisional; Region: PRK11043
99287004223	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287004224	putative substrate translocation pore; other site
99287004225	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
99287004226	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287004227	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287004228	dimerization interface [polypeptide binding]; other site
99287004229	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
99287004230	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287004231	DNA binding site [nucleotide binding]
99287004232	domain linker motif; other site
99287004233	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
99287004234	dimerization interface [polypeptide binding]; other site
99287004235	ligand binding site [chemical binding]; other site
99287004236	superoxide dismutase; Provisional; Region: PRK10543
99287004237	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
99287004238	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
99287004239	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
99287004240	NlpC/P60 family; Region: NLPC_P60; pfam00877
99287004241	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
99287004242	putative GSH binding site [chemical binding]; other site
99287004243	catalytic residues [active]
99287004244	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
99287004245	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
99287004246	dimer interface [polypeptide binding]; other site
99287004247	catalytic site [active]
99287004248	putative active site [active]
99287004249	putative substrate binding site [chemical binding]; other site
99287004250	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
99287004251	dimer interface [polypeptide binding]; other site
99287004252	active site
99287004253	metal binding site [ion binding]; metal-binding site
99287004254	glutathione binding site [chemical binding]; other site
99287004255	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
99287004256	FMN binding site [chemical binding]; other site
99287004257	active site
99287004258	substrate binding site [chemical binding]; other site
99287004259	catalytic residue [active]
99287004260	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99287004261	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287004262	Predicted Fe-S protein [General function prediction only]; Region: COG3313
99287004263	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99287004264	active site
99287004265	catalytic tetrad [active]
99287004266	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
99287004267	E-class dimer interface [polypeptide binding]; other site
99287004268	P-class dimer interface [polypeptide binding]; other site
99287004269	active site
99287004270	Cu2+ binding site [ion binding]; other site
99287004271	Zn2+ binding site [ion binding]; other site
99287004272	Fusaric acid resistance protein family; Region: FUSC; pfam04632
99287004273	Fusaric acid resistance protein-like; Region: FUSC_2; cl19401
99287004274	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
99287004275	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99287004276	HlyD family secretion protein; Region: HlyD_3; pfam13437
99287004277	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
99287004278	transcriptional regulator SlyA; Provisional; Region: PRK03573
99287004279	Transcriptional regulators [Transcription]; Region: MarR; COG1846
99287004280	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
99287004281	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
99287004282	lysozyme inhibitor; Provisional; Region: PRK11372
99287004283	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
99287004284	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
99287004285	Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590
99287004286	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
99287004287	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
99287004288	active site
99287004289	HIGH motif; other site
99287004290	dimer interface [polypeptide binding]; other site
99287004291	KMSKS motif; other site
99287004292	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99287004293	RNA binding surface [nucleotide binding]; other site
99287004294	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
99287004295	dimer interface [polypeptide binding]; other site
99287004296	pyridoxal binding site [chemical binding]; other site
99287004297	ATP binding site [chemical binding]; other site
99287004298	glutathionine S-transferase; Provisional; Region: PRK10542
99287004299	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
99287004300	C-terminal domain interface [polypeptide binding]; other site
99287004301	GSH binding site (G-site) [chemical binding]; other site
99287004302	dimer interface [polypeptide binding]; other site
99287004303	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
99287004304	dimer interface [polypeptide binding]; other site
99287004305	N-terminal domain interface [polypeptide binding]; other site
99287004306	substrate binding pocket (H-site) [chemical binding]; other site
99287004307	putative tripeptide transporter permease; Reviewed; Region: tppB; PRK09584
99287004308	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
99287004309	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287004310	putative substrate translocation pore; other site
99287004311	endonuclease III; Provisional; Region: PRK10702
99287004312	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
99287004313	minor groove reading motif; other site
99287004314	helix-hairpin-helix signature motif; other site
99287004315	substrate binding pocket [chemical binding]; other site
99287004316	active site
99287004317	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
99287004318	electron transport complex RsxE subunit; Provisional; Region: PRK12405
99287004319	electron transport complex protein RnfG; Validated; Region: PRK01908
99287004320	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
99287004321	electron transport complex protein RnfC; Provisional; Region: PRK05035
99287004322	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
99287004323	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
99287004324	SLBB domain; Region: SLBB; pfam10531
99287004325	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
99287004326	electron transport complex protein RnfB; Provisional; Region: PRK05113
99287004327	Putative Fe-S cluster; Region: FeS; cl17515
99287004328	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287004329	electron transport complex protein RsxA; Provisional; Region: PRK05151
99287004330	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
99287004331	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
99287004332	putative oxidoreductase; Provisional; Region: PRK11579
99287004333	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99287004334	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
99287004335	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
99287004336	active site
99287004337	purine riboside binding site [chemical binding]; other site
99287004338	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
99287004339	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
99287004340	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
99287004341	fumarate hydratase; Provisional; Region: PRK15389
99287004342	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
99287004343	Fumarase C-terminus; Region: Fumerase_C; pfam05683
99287004344	fumarate hydratase; Reviewed; Region: fumC; PRK00485
99287004345	Class II fumarases; Region: Fumarase_classII; cd01362
99287004346	active site
99287004347	tetramer interface [polypeptide binding]; other site
99287004348	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
99287004349	sensor protein RstB; Provisional; Region: PRK10604
99287004350	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287004351	dimerization interface [polypeptide binding]; other site
99287004352	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287004353	dimer interface [polypeptide binding]; other site
99287004354	phosphorylation site [posttranslational modification]
99287004355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287004356	ATP binding site [chemical binding]; other site
99287004357	Mg2+ binding site [ion binding]; other site
99287004358	G-X-G motif; other site
99287004359	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
99287004360	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
99287004361	active site
99287004362	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
99287004363	trimer interface [polypeptide binding]; other site
99287004364	eyelet of channel; other site
99287004365	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
99287004366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287004367	active site
99287004368	phosphorylation site [posttranslational modification]
99287004369	intermolecular recognition site; other site
99287004370	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287004371	DNA binding site [nucleotide binding]
99287004372	GlpM protein; Region: GlpM; pfam06942
99287004373	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
99287004374	Spore germination protein; Region: Spore_permease; cl17796
99287004375	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
99287004376	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
99287004377	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
99287004378	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
99287004379	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
99287004380	ligand binding site [chemical binding]; other site
99287004381	homodimer interface [polypeptide binding]; other site
99287004382	NAD(P) binding site [chemical binding]; other site
99287004383	trimer interface B [polypeptide binding]; other site
99287004384	trimer interface A [polypeptide binding]; other site
99287004385	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
99287004386	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
99287004387	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
99287004388	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
99287004389	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
99287004390	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
99287004391	acid shock protein precursor; Provisional; Region: PRK03577
99287004392	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
99287004393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287004394	putative substrate translocation pore; other site
99287004395	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
99287004396	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287004397	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
99287004398	dimerization interface [polypeptide binding]; other site
99287004399	substrate binding pocket [chemical binding]; other site
99287004400	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
99287004401	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
99287004402	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99287004403	nucleotide binding site [chemical binding]; other site
99287004404	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
99287004405	putative dithiobiotin synthetase; Provisional; Region: PRK12374
99287004406	AAA domain; Region: AAA_26; pfam13500
99287004407	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
99287004408	Cl- selectivity filter; other site
99287004409	Cl- binding residues [ion binding]; other site
99287004410	pore gating glutamate residue; other site
99287004411	dimer interface [polypeptide binding]; other site
99287004412	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
99287004413	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287004414	Walker A/P-loop; other site
99287004415	ATP binding site [chemical binding]; other site
99287004416	Q-loop/lid; other site
99287004417	ABC transporter signature motif; other site
99287004418	Walker B; other site
99287004419	D-loop; other site
99287004420	H-loop/switch region; other site
99287004421	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
99287004422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287004423	dimer interface [polypeptide binding]; other site
99287004424	conserved gate region; other site
99287004425	putative PBP binding loops; other site
99287004426	ABC-ATPase subunit interface; other site
99287004427	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
99287004428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287004429	dimer interface [polypeptide binding]; other site
99287004430	conserved gate region; other site
99287004431	putative PBP binding loops; other site
99287004432	ABC-ATPase subunit interface; other site
99287004433	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
99287004434	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
99287004435	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
99287004436	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287004437	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
99287004438	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
99287004439	putative [Fe4-S4] binding site [ion binding]; other site
99287004440	putative molybdopterin cofactor binding site [chemical binding]; other site
99287004441	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
99287004442	putative molybdopterin cofactor binding site; other site
99287004443	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
99287004444	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
99287004445	putative [Fe4-S4] binding site [ion binding]; other site
99287004446	putative molybdopterin cofactor binding site [chemical binding]; other site
99287004447	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
99287004448	putative molybdopterin cofactor binding site; other site
99287004449	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
99287004450	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
99287004451	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
99287004452	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287004453	Coenzyme A binding pocket [chemical binding]; other site
99287004454	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
99287004455	hypothetical protein; Provisional; Region: PRK13659
99287004456	hypothetical protein; Provisional; Region: PRK02237
99287004457	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
99287004458	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
99287004459	putative active site pocket [active]
99287004460	putative metal binding site [ion binding]; other site
99287004461	putative oxidoreductase; Provisional; Region: PRK10083
99287004462	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
99287004463	putative NAD(P) binding site [chemical binding]; other site
99287004464	catalytic Zn binding site [ion binding]; other site
99287004465	structural Zn binding site [ion binding]; other site
99287004466	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
99287004467	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
99287004468	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
99287004469	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
99287004470	Transcriptional regulators [Transcription]; Region: GntR; COG1802
99287004471	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287004472	DNA-binding site [nucleotide binding]; DNA binding site
99287004473	FCD domain; Region: FCD; pfam07729
99287004474	malonic semialdehyde reductase; Provisional; Region: PRK10538
99287004475	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
99287004476	putative NAD(P) binding site [chemical binding]; other site
99287004477	homodimer interface [polypeptide binding]; other site
99287004478	homotetramer interface [polypeptide binding]; other site
99287004479	active site
99287004480	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
99287004481	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
99287004482	active site
99287004483	Zn binding site [ion binding]; other site
99287004484	General stress protein [General function prediction only]; Region: GsiB; COG3729
99287004485	hypothetical protein; Validated; Region: PRK03657
99287004486	hypothetical protein; Provisional; Region: PRK10053
99287004487	putative transporter; Provisional; Region: PRK10054
99287004488	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287004489	putative substrate translocation pore; other site
99287004490	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
99287004491	EamA-like transporter family; Region: EamA; pfam00892
99287004492	EamA-like transporter family; Region: EamA; pfam00892
99287004493	MarB protein; Region: MarB; pfam13999
99287004494	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
99287004495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287004496	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287004497	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
99287004498	Transcriptional regulators [Transcription]; Region: MarR; COG1846
99287004499	inner membrane protein; Provisional; Region: PRK10995
99287004500	putative arabinose transporter; Provisional; Region: PRK03545
99287004501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287004502	putative substrate translocation pore; other site
99287004503	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287004504	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287004505	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
99287004506	putative dimerization interface [polypeptide binding]; other site
99287004507	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
99287004508	NAD(P) binding site [chemical binding]; other site
99287004509	catalytic residues [active]
99287004510	glutaminase; Provisional; Region: PRK00971
99287004511	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
99287004512	Predicted membrane protein [Function unknown]; Region: COG3781
99287004513	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
99287004514	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
99287004515	trimer interface [polypeptide binding]; other site
99287004516	eyelet of channel; other site
99287004517	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
99287004518	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174
99287004519	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
99287004520	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
99287004521	Rubredoxin [Energy production and conversion]; Region: COG1773
99287004522	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
99287004523	iron binding site [ion binding]; other site
99287004524	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
99287004525	HupF/HypC family; Region: HupF_HypC; cl00394
99287004526	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
99287004527	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
99287004528	putative substrate-binding site; other site
99287004529	nickel binding site [ion binding]; other site
99287004530	Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969
99287004531	hydrogenase 1 large subunit; Provisional; Region: PRK10170
99287004532	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
99287004533	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
99287004534	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
99287004535	NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720
99287004536	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
99287004537	active site
99287004538	Transcriptional regulators [Transcription]; Region: FadR; COG2186
99287004539	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287004540	DNA-binding site [nucleotide binding]; DNA binding site
99287004541	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
99287004542	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
99287004543	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
99287004544	putative NAD(P) binding site [chemical binding]; other site
99287004545	catalytic Zn binding site [ion binding]; other site
99287004546	structural Zn binding site [ion binding]; other site
99287004547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287004548	D-galactonate transporter; Region: 2A0114; TIGR00893
99287004549	putative substrate translocation pore; other site
99287004550	PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287
99287004551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287004552	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99287004553	putative substrate translocation pore; other site
99287004554	hypothetical protein; Provisional; Region: PRK06184
99287004555	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287004556	CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655
99287004557	Transcriptional regulators [Transcription]; Region: MarR; COG1846
99287004558	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99287004559	putative DNA binding site [nucleotide binding]; other site
99287004560	putative Zn2+ binding site [ion binding]; other site
99287004561	S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809
99287004562	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
99287004563	homotrimer interaction site [polypeptide binding]; other site
99287004564	putative active site [active]
99287004565	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
99287004566	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
99287004567	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
99287004568	Transcriptional regulators [Transcription]; Region: PurR; COG1609
99287004569	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287004570	DNA binding site [nucleotide binding]
99287004571	domain linker motif; other site
99287004572	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
99287004573	dimerization interface (closed form) [polypeptide binding]; other site
99287004574	ligand binding site [chemical binding]; other site
99287004575	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
99287004576	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
99287004577	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
99287004578	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
99287004579	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99287004580	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287004581	homodimer interface [polypeptide binding]; other site
99287004582	catalytic residue [active]
99287004583	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
99287004584	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
99287004585	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
99287004586	active site
99287004587	catalytic site [active]
99287004588	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
99287004589	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
99287004590	active site
99287004591	catalytic site [active]
99287004592	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
99287004593	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
99287004594	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
99287004595	catalytic site [active]
99287004596	active site
99287004597	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
99287004598	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
99287004599	acid-resistance protein; Provisional; Region: hdeB; PRK11566
99287004600	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
99287004601	biofilm-dependent modulation protein; Provisional; Region: PRK11436
99287004602	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
99287004603	malate dehydrogenase; Provisional; Region: PRK13529
99287004604	Malic enzyme, N-terminal domain; Region: malic; pfam00390
99287004605	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
99287004606	NAD(P) binding site [chemical binding]; other site
99287004607	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
99287004608	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
99287004609	NAD binding site [chemical binding]; other site
99287004610	substrate binding site [chemical binding]; other site
99287004611	catalytic Zn binding site [ion binding]; other site
99287004612	tetramer interface [polypeptide binding]; other site
99287004613	structural Zn binding site [ion binding]; other site
99287004614	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
99287004615	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
99287004616	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287004617	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
99287004618	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
99287004619	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
99287004620	[4Fe-4S] binding site [ion binding]; other site
99287004621	molybdopterin cofactor binding site; other site
99287004622	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
99287004623	molybdopterin cofactor binding site; other site
99287004624	aromatic amino acid exporter; Provisional; Region: PRK11689
99287004625	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
99287004626	trimer interface [polypeptide binding]; other site
99287004627	eyelet of channel; other site
99287004628	Uncharacterized conserved protein [Function unknown]; Region: COG3791
99287004629	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
99287004630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287004631	putative substrate translocation pore; other site
99287004632	TetR family transcriptional regulator; Provisional; Region: PRK14996
99287004633	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287004634	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
99287004635	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
99287004636	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
99287004637	Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710
99287004638	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
99287004639	[4Fe-4S] binding site [ion binding]; other site
99287004640	molybdopterin cofactor binding site [chemical binding]; other site
99287004641	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
99287004642	molybdopterin cofactor binding site; other site
99287004643	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
99287004644	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287004645	Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711
99287004646	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
99287004647	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
99287004648	hypothetical protein; Provisional; Region: PRK10281
99287004649	phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654
99287004650	N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047
99287004651	L-asparagine permease; Provisional; Region: PRK15049
99287004652	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
99287004653	Uncharacterized conserved protein [Function unknown]; Region: COG3391
99287004654	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
99287004655	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
99287004656	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99287004657	N-terminal plug; other site
99287004658	ligand-binding site [chemical binding]; other site
99287004659	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
99287004660	DNA-binding site [nucleotide binding]; DNA binding site
99287004661	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
99287004662	FCD domain; Region: FCD; pfam07729
99287004663	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
99287004664	Prostaglandin dehydrogenases; Region: PGDH; cd05288
99287004665	NAD(P) binding site [chemical binding]; other site
99287004666	substrate binding site [chemical binding]; other site
99287004667	dimer interface [polypeptide binding]; other site
99287004668	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
99287004669	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287004670	Coenzyme A binding pocket [chemical binding]; other site
99287004671	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
99287004672	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
99287004673	large tegument protein UL36; Provisional; Region: PHA03247
99287004674	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457
99287004675	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458
99287004676	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
99287004677	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
99287004678	tetrameric interface [polypeptide binding]; other site
99287004679	NAD binding site [chemical binding]; other site
99287004680	catalytic residues [active]
99287004681	substrate binding site [chemical binding]; other site
99287004682	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
99287004683	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287004684	DNA-binding site [nucleotide binding]; DNA binding site
99287004685	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99287004686	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287004687	homodimer interface [polypeptide binding]; other site
99287004688	catalytic residue [active]
99287004689	D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173
99287004690	secreted effector protein SifB; Provisional; Region: sifB; PRK09499
99287004691	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
99287004692	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
99287004693	Collagenase; Region: DUF3656; pfam12392
99287004694	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
99287004695	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287004696	non-specific DNA binding site [nucleotide binding]; other site
99287004697	salt bridge; other site
99287004698	sequence-specific DNA binding site [nucleotide binding]; other site
99287004699	Cupin domain; Region: Cupin_2; pfam07883
99287004700	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
99287004701	benzoate transporter; Region: benE; TIGR00843
99287004702	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
99287004703	tellurite resistance protein TehB; Provisional; Region: PRK11207
99287004704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287004705	S-adenosylmethionine binding site [chemical binding]; other site
99287004706	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
99287004707	gating phenylalanine in ion channel; other site
99287004708	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
99287004709	putative trimer interface [polypeptide binding]; other site
99287004710	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
99287004711	putative trimer interface [polypeptide binding]; other site
99287004712	putative CoA binding site [chemical binding]; other site
99287004713	putative CoA binding site [chemical binding]; other site
99287004714	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
99287004715	putative trimer interface [polypeptide binding]; other site
99287004716	putative CoA binding site [chemical binding]; other site
99287004717	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
99287004718	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287004719	Coenzyme A binding pocket [chemical binding]; other site
99287004720	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
99287004721	oligomer interface [polypeptide binding]; other site
99287004722	active site
99287004723	metal binding site [ion binding]; metal-binding site
99287004724	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
99287004725	active site
99287004726	P-loop; other site
99287004727	phosphorylation site [posttranslational modification]
99287004728	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
99287004729	membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259
99287004730	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
99287004731	active site
99287004732	phosphorylation site [posttranslational modification]
99287004733	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
99287004734	substrate binding site [chemical binding]; other site
99287004735	hexamer interface [polypeptide binding]; other site
99287004736	metal binding site [ion binding]; metal-binding site
99287004737	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
99287004738	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
99287004739	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287004740	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
99287004741	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287004742	Coenzyme A binding pocket [chemical binding]; other site
99287004743	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
99287004744	teramer interface [polypeptide binding]; other site
99287004745	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
99287004746	active site
99287004747	FMN binding site [chemical binding]; other site
99287004748	catalytic residues [active]
99287004749	Uncharacterized conserved protein [Function unknown]; Region: COG2353
99287004750	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
99287004751	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
99287004752	substrate binding pocket [chemical binding]; other site
99287004753	catalytic triad [active]
99287004754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
99287004755	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
99287004756	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287004757	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287004758	dimerization interface [polypeptide binding]; other site
99287004759	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
99287004760	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
99287004761	dimer interface [polypeptide binding]; other site
99287004762	ligand binding site [chemical binding]; other site
99287004763	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287004764	dimerization interface [polypeptide binding]; other site
99287004765	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
99287004766	dimer interface [polypeptide binding]; other site
99287004767	putative CheW interface [polypeptide binding]; other site
99287004768	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
99287004769	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
99287004770	substrate binding site [chemical binding]; other site
99287004771	catalytic Zn binding site [ion binding]; other site
99287004772	NAD binding site [chemical binding]; other site
99287004773	structural Zn binding site [ion binding]; other site
99287004774	dimer interface [polypeptide binding]; other site
99287004775	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
99287004776	putative metal binding site [ion binding]; other site
99287004777	putative homodimer interface [polypeptide binding]; other site
99287004778	putative homotetramer interface [polypeptide binding]; other site
99287004779	putative homodimer-homodimer interface [polypeptide binding]; other site
99287004780	putative allosteric switch controlling residues; other site
99287004781	Sif protein; Region: Sif; cl11505
99287004782	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
99287004783	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
99287004784	active site
99287004785	catalytic triad [active]
99287004786	oxyanion hole [active]
99287004787	Predicted membrane protein [Function unknown]; Region: COG3326
99287004788	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287004789	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
99287004790	substrate binding pocket [chemical binding]; other site
99287004791	membrane-bound complex binding site; other site
99287004792	hinge residues; other site
99287004793	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
99287004794	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287004795	dimer interface [polypeptide binding]; other site
99287004796	conserved gate region; other site
99287004797	putative PBP binding loops; other site
99287004798	ABC-ATPase subunit interface; other site
99287004799	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
99287004800	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287004801	Walker A/P-loop; other site
99287004802	ATP binding site [chemical binding]; other site
99287004803	Q-loop/lid; other site
99287004804	ABC transporter signature motif; other site
99287004805	Walker B; other site
99287004806	D-loop; other site
99287004807	H-loop/switch region; other site
99287004808	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
99287004809	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287004810	dimer interface [polypeptide binding]; other site
99287004811	conserved gate region; other site
99287004812	putative PBP binding loops; other site
99287004813	ABC-ATPase subunit interface; other site
99287004814	Predicted membrane protein [Function unknown]; Region: COG5305
99287004815	Methyltransferase domain; Region: Methyltransf_12; pfam08242
99287004816	cytochrome b561; Provisional; Region: PRK11513
99287004817	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
99287004818	putative active site [active]
99287004819	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
99287004820	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99287004821	ATP binding site [chemical binding]; other site
99287004822	putative Mg++ binding site [ion binding]; other site
99287004823	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287004824	nucleotide binding region [chemical binding]; other site
99287004825	ATP-binding site [chemical binding]; other site
99287004826	Helicase associated domain (HA2); Region: HA2; pfam04408
99287004827	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
99287004828	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
99287004829	azoreductase; Reviewed; Region: PRK00170
99287004830	Uncharacterized conserved protein [Function unknown]; Region: COG3791
99287004831	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
99287004832	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
99287004833	hypothetical protein; Provisional; Region: PRK10695
99287004834	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
99287004835	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
99287004836	putative ligand binding site [chemical binding]; other site
99287004837	putative NAD binding site [chemical binding]; other site
99287004838	catalytic site [active]
99287004839	heat-inducible protein; Provisional; Region: PRK10449
99287004840	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
99287004841	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
99287004842	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
99287004843	dimer interface [polypeptide binding]; other site
99287004844	PYR/PP interface [polypeptide binding]; other site
99287004845	TPP binding site [chemical binding]; other site
99287004846	substrate binding site [chemical binding]; other site
99287004847	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
99287004848	Domain of unknown function; Region: EKR; pfam10371
99287004849	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
99287004850	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
99287004851	TPP-binding site [chemical binding]; other site
99287004852	dimer interface [polypeptide binding]; other site
99287004853	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99287004854	Ligand Binding Site [chemical binding]; other site
99287004855	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
99287004856	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
99287004857	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
99287004858	Ligand Binding Site [chemical binding]; other site
99287004859	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
99287004860	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
99287004861	ATP binding site [chemical binding]; other site
99287004862	Mg++ binding site [ion binding]; other site
99287004863	motif III; other site
99287004864	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287004865	nucleotide binding region [chemical binding]; other site
99287004866	ATP-binding site [chemical binding]; other site
99287004867	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
99287004868	putative RNA binding site [nucleotide binding]; other site
99287004869	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
99287004870	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
99287004871	Cl binding site [ion binding]; other site
99287004872	oligomer interface [polypeptide binding]; other site
99287004873	HAMP domain; Region: HAMP; pfam00672
99287004874	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
99287004875	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
99287004876	dimer interface [polypeptide binding]; other site
99287004877	putative CheW interface [polypeptide binding]; other site
99287004878	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
99287004879	Smr domain; Region: Smr; pfam01713
99287004880	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
99287004881	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
99287004882	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
99287004883	DNA binding site [nucleotide binding]
99287004884	active site
99287004885	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
99287004886	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99287004887	ligand binding site [chemical binding]; other site
99287004888	flexible hinge region; other site
99287004889	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
99287004890	putative switch regulator; other site
99287004891	non-specific DNA interactions [nucleotide binding]; other site
99287004892	DNA binding site [nucleotide binding]
99287004893	sequence specific DNA binding site [nucleotide binding]; other site
99287004894	putative cAMP binding site [chemical binding]; other site
99287004895	universal stress protein UspE; Provisional; Region: PRK11175
99287004896	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99287004897	Ligand Binding Site [chemical binding]; other site
99287004898	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99287004899	Ligand Binding Site [chemical binding]; other site
99287004900	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
99287004901	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
99287004902	Mechanosensitive ion channel; Region: MS_channel; pfam00924
99287004903	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
99287004904	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287004905	non-specific DNA binding site [nucleotide binding]; other site
99287004906	salt bridge; other site
99287004907	sequence-specific DNA binding site [nucleotide binding]; other site
99287004908	Cupin domain; Region: Cupin_2; pfam07883
99287004909	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
99287004910	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077
99287004911	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
99287004912	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
99287004913	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287004914	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
99287004915	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
99287004916	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
99287004917	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287004918	oxidoreductase; Provisional; Region: PRK12742
99287004919	classical (c) SDRs; Region: SDR_c; cd05233
99287004920	NAD(P) binding site [chemical binding]; other site
99287004921	active site
99287004922	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99287004923	active site
99287004924	catalytic tetrad [active]
99287004925	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287004926	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287004927	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
99287004928	putative effector binding pocket; other site
99287004929	putative dimerization interface [polypeptide binding]; other site
99287004930	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
99287004931	NAD(P) binding site [chemical binding]; other site
99287004932	active site lysine
99287004933	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
99287004934	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
99287004935	peptide binding site [polypeptide binding]; other site
99287004936	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
99287004937	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
99287004938	putative active site [active]
99287004939	Zn binding site [ion binding]; other site
99287004940	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
99287004941	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
99287004942	active site
99287004943	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
99287004944	dimer interface [polypeptide binding]; other site
99287004945	catalytic triad [active]
99287004946	peroxidatic and resolving cysteines [active]
99287004947	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
99287004948	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
99287004949	putative aromatic amino acid binding site; other site
99287004950	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99287004951	putative active site [active]
99287004952	heme pocket [chemical binding]; other site
99287004953	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287004954	Walker A motif; other site
99287004955	ATP binding site [chemical binding]; other site
99287004956	Walker B motif; other site
99287004957	arginine finger; other site
99287004958	hypothetical protein; Provisional; Region: PRK05415
99287004959	Predicted membrane protein [Function unknown]; Region: COG3768
99287004960	Predicted ATPase [General function prediction only]; Region: COG3106
99287004961	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
99287004962	active site residue [active]
99287004963	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
99287004964	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
99287004965	phage shock protein C; Region: phageshock_pspC; TIGR02978
99287004966	phage shock protein B; Provisional; Region: pspB; PRK09458
99287004967	phage shock protein PspA; Provisional; Region: PRK10698
99287004968	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
99287004969	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
99287004970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287004971	Walker A motif; other site
99287004972	ATP binding site [chemical binding]; other site
99287004973	Walker B motif; other site
99287004974	arginine finger; other site
99287004975	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
99287004976	antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109
99287004977	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
99287004978	peptide binding site [polypeptide binding]; other site
99287004979	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168
99287004980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287004981	dimer interface [polypeptide binding]; other site
99287004982	conserved gate region; other site
99287004983	putative PBP binding loops; other site
99287004984	ABC-ATPase subunit interface; other site
99287004985	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
99287004986	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
99287004987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287004988	dimer interface [polypeptide binding]; other site
99287004989	conserved gate region; other site
99287004990	putative PBP binding loops; other site
99287004991	ABC-ATPase subunit interface; other site
99287004992	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
99287004993	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99287004994	Walker A/P-loop; other site
99287004995	ATP binding site [chemical binding]; other site
99287004996	Q-loop/lid; other site
99287004997	ABC transporter signature motif; other site
99287004998	Walker B; other site
99287004999	D-loop; other site
99287005000	H-loop/switch region; other site
99287005001	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
99287005002	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
99287005003	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99287005004	Walker A/P-loop; other site
99287005005	ATP binding site [chemical binding]; other site
99287005006	Q-loop/lid; other site
99287005007	ABC transporter signature motif; other site
99287005008	Walker B; other site
99287005009	D-loop; other site
99287005010	H-loop/switch region; other site
99287005011	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
99287005012	Protein kinase domain; Region: Pkinase; pfam00069
99287005013	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
99287005014	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
99287005015	NAD binding site [chemical binding]; other site
99287005016	homotetramer interface [polypeptide binding]; other site
99287005017	homodimer interface [polypeptide binding]; other site
99287005018	substrate binding site [chemical binding]; other site
99287005019	active site
99287005020	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950
99287005021	Uncharacterized conserved protein [Function unknown]; Region: COG2128
99287005022	exoribonuclease II; Provisional; Region: PRK05054
99287005023	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
99287005024	RNB domain; Region: RNB; pfam00773
99287005025	S1 RNA binding domain; Region: S1; pfam00575
99287005026	RNase II stability modulator; Provisional; Region: PRK10060
99287005027	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99287005028	putative active site [active]
99287005029	heme pocket [chemical binding]; other site
99287005030	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99287005031	metal binding site [ion binding]; metal-binding site
99287005032	active site
99287005033	I-site; other site
99287005034	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287005035	hypothetical protein; Provisional; Region: PRK13658
99287005036	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
99287005037	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
99287005038	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287005039	lipoprotein; Provisional; Region: PRK10540
99287005040	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
99287005041	putative rRNA binding site [nucleotide binding]; other site
99287005042	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
99287005043	active site
99287005044	dimer interface [polypeptide binding]; other site
99287005045	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
99287005046	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287005047	TPR motif; other site
99287005048	binding surface
99287005049	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287005050	binding surface
99287005051	TPR motif; other site
99287005052	Predicted membrane protein [Function unknown]; Region: COG3771
99287005053	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
99287005054	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
99287005055	active site
99287005056	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
99287005057	dimerization interface [polypeptide binding]; other site
99287005058	active site
99287005059	aconitate hydratase; Validated; Region: PRK09277
99287005060	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
99287005061	substrate binding site [chemical binding]; other site
99287005062	ligand binding site [chemical binding]; other site
99287005063	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
99287005064	substrate binding site [chemical binding]; other site
99287005065	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
99287005066	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287005067	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
99287005068	substrate binding site [chemical binding]; other site
99287005069	putative dimerization interface [polypeptide binding]; other site
99287005070	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
99287005071	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
99287005072	active site
99287005073	interdomain interaction site; other site
99287005074	putative metal-binding site [ion binding]; other site
99287005075	nucleotide binding site [chemical binding]; other site
99287005076	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
99287005077	domain I; other site
99287005078	DNA binding groove [nucleotide binding]
99287005079	phosphate binding site [ion binding]; other site
99287005080	domain II; other site
99287005081	domain III; other site
99287005082	nucleotide binding site [chemical binding]; other site
99287005083	catalytic site [active]
99287005084	domain IV; other site
99287005085	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
99287005086	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
99287005087	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
99287005088	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
99287005089	hypothetical protein; Provisional; Region: PRK11037
99287005090	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
99287005091	putative inner membrane peptidase; Provisional; Region: PRK11778
99287005092	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
99287005093	tandem repeat interface [polypeptide binding]; other site
99287005094	oligomer interface [polypeptide binding]; other site
99287005095	active site residues [active]
99287005096	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
99287005097	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
99287005098	NADP binding site [chemical binding]; other site
99287005099	homodimer interface [polypeptide binding]; other site
99287005100	active site
99287005101	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
99287005102	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
99287005103	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
99287005104	homodimer interface [polypeptide binding]; other site
99287005105	Walker A motif; other site
99287005106	ATP binding site [chemical binding]; other site
99287005107	hydroxycobalamin binding site [chemical binding]; other site
99287005108	Walker B motif; other site
99287005109	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
99287005110	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99287005111	RNA binding surface [nucleotide binding]; other site
99287005112	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
99287005113	probable active site [active]
99287005114	hypothetical protein; Provisional; Region: PRK11630
99287005115	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
99287005116	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
99287005117	active site
99287005118	anthranilate synthase component I; Provisional; Region: PRK13564
99287005119	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
99287005120	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
99287005121	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
99287005122	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
99287005123	glutamine binding [chemical binding]; other site
99287005124	catalytic triad [active]
99287005125	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
99287005126	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
99287005127	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
99287005128	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
99287005129	active site
99287005130	ribulose/triose binding site [chemical binding]; other site
99287005131	phosphate binding site [ion binding]; other site
99287005132	substrate (anthranilate) binding pocket [chemical binding]; other site
99287005133	product (indole) binding pocket [chemical binding]; other site
99287005134	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
99287005135	active site
99287005136	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
99287005137	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287005138	catalytic residue [active]
99287005139	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
99287005140	substrate binding site [chemical binding]; other site
99287005141	active site
99287005142	catalytic residues [active]
99287005143	heterodimer interface [polypeptide binding]; other site
99287005144	General stress protein [General function prediction only]; Region: GsiB; COG3729
99287005145	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
99287005146	dimerization interface [polypeptide binding]; other site
99287005147	metal binding site [ion binding]; metal-binding site
99287005148	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
99287005149	dinuclear metal binding motif [ion binding]; other site
99287005150	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
99287005151	dimanganese center [ion binding]; other site
99287005152	outer membrane protein W; Provisional; Region: PRK10959
99287005153	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
99287005154	hypothetical protein; Provisional; Region: PRK02868
99287005155	intracellular septation protein A; Reviewed; Region: PRK00259
99287005156	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
99287005157	transport protein TonB; Provisional; Region: PRK10819
99287005158	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
99287005159	YciI-like protein; Reviewed; Region: PRK11370
99287005160	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
99287005161	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
99287005162	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
99287005163	putative active site [active]
99287005164	catalytic site [active]
99287005165	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
99287005166	putative active site [active]
99287005167	catalytic site [active]
99287005168	dsDNA-mimic protein; Reviewed; Region: PRK05094
99287005169	Ion transport protein; Region: Ion_trans; pfam00520
99287005170	Ion channel; Region: Ion_trans_2; pfam07885
99287005171	Double zinc ribbon; Region: DZR; pfam12773
99287005172	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
99287005173	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99287005174	Walker A/P-loop; other site
99287005175	ATP binding site [chemical binding]; other site
99287005176	Q-loop/lid; other site
99287005177	ABC transporter signature motif; other site
99287005178	Walker B; other site
99287005179	D-loop; other site
99287005180	H-loop/switch region; other site
99287005181	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
99287005182	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
99287005183	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99287005184	Walker A/P-loop; other site
99287005185	ATP binding site [chemical binding]; other site
99287005186	Q-loop/lid; other site
99287005187	ABC transporter signature motif; other site
99287005188	Walker B; other site
99287005189	D-loop; other site
99287005190	H-loop/switch region; other site
99287005191	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
99287005192	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
99287005193	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
99287005194	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287005195	dimer interface [polypeptide binding]; other site
99287005196	conserved gate region; other site
99287005197	putative PBP binding loops; other site
99287005198	ABC-ATPase subunit interface; other site
99287005199	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
99287005200	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287005201	dimer interface [polypeptide binding]; other site
99287005202	conserved gate region; other site
99287005203	putative PBP binding loops; other site
99287005204	ABC-ATPase subunit interface; other site
99287005205	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
99287005206	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
99287005207	peptide binding site [polypeptide binding]; other site
99287005208	hypothetical protein; Provisional; Region: PRK11111
99287005209	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
99287005210	Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081
99287005211	putative catalytic cysteine [active]
99287005212	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
99287005213	putative active site [active]
99287005214	metal binding site [ion binding]; metal-binding site
99287005215	thymidine kinase; Provisional; Region: PRK04296
99287005216	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
99287005217	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
99287005218	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
99287005219	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
99287005220	active site
99287005221	tetramer interface; other site
99287005222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287005223	active site
99287005224	response regulator of RpoS; Provisional; Region: PRK10693
99287005225	phosphorylation site [posttranslational modification]
99287005226	intermolecular recognition site; other site
99287005227	dimerization interface [polypeptide binding]; other site
99287005228	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
99287005229	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
99287005230	active site
99287005231	nucleophile elbow; other site
99287005232	hypothetical protein; Provisional; Region: PRK01617
99287005233	SEC-C motif; Region: SEC-C; cl19389
99287005234	SEC-C motif; Region: SEC-C; cl19389
99287005235	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
99287005236	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
99287005237	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
99287005238	putative active site [active]
99287005239	putative substrate binding site [chemical binding]; other site
99287005240	putative cosubstrate binding site; other site
99287005241	catalytic site [active]
99287005242	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
99287005243	Sel1-like repeats; Region: SEL1; smart00671
99287005244	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
99287005245	Sel1-like repeats; Region: SEL1; smart00671
99287005246	Sel1-like repeats; Region: SEL1; smart00671
99287005247	Sel1-like repeats; Region: SEL1; smart00671
99287005248	Sel1-like repeats; Region: SEL1; smart00671
99287005249	Sel1-like repeats; Region: SEL1; smart00671
99287005250	Sel1-like repeats; Region: SEL1; smart00671
99287005251	Sel1-like repeats; Region: SEL1; smart00671
99287005252	Sel1-like repeats; Region: SEL1; smart00671
99287005253	Sel1-like repeats; Region: SEL1; smart00671
99287005254	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
99287005255	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
99287005256	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
99287005257	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287005258	Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711
99287005259	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
99287005260	Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710
99287005261	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
99287005262	[4Fe-4S] binding site [ion binding]; other site
99287005263	molybdopterin cofactor binding site [chemical binding]; other site
99287005264	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
99287005265	molybdopterin cofactor binding site; other site
99287005266	lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150
99287005267	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
99287005268	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
99287005269	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
99287005270	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287005271	dimerization interface [polypeptide binding]; other site
99287005272	Histidine kinase; Region: HisKA_3; pfam07730
99287005273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287005274	ATP binding site [chemical binding]; other site
99287005275	Mg2+ binding site [ion binding]; other site
99287005276	G-X-G motif; other site
99287005277	transcriptional regulator NarL; Provisional; Region: PRK10651
99287005278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287005279	active site
99287005280	phosphorylation site [posttranslational modification]
99287005281	intermolecular recognition site; other site
99287005282	dimerization interface [polypeptide binding]; other site
99287005283	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287005284	DNA binding residues [nucleotide binding]
99287005285	dimerization interface [polypeptide binding]; other site
99287005286	putative invasin; Provisional; Region: PRK10177
99287005287	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
99287005288	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
99287005289	cation transport regulator; Reviewed; Region: chaB; PRK09582
99287005290	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
99287005291	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
99287005292	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
99287005293	hypothetical protein; Provisional; Region: PRK10941
99287005294	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
99287005295	hypothetical protein; Provisional; Region: PRK10278
99287005296	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
99287005297	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287005298	S-adenosylmethionine binding site [chemical binding]; other site
99287005299	peptide chain release factor 1; Validated; Region: prfA; PRK00591
99287005300	This domain is found in peptide chain release factors; Region: PCRF; smart00937
99287005301	RF-1 domain; Region: RF-1; pfam00472
99287005302	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
99287005303	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
99287005304	tRNA; other site
99287005305	putative tRNA binding site [nucleotide binding]; other site
99287005306	putative NADP binding site [chemical binding]; other site
99287005307	Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745
99287005308	Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017
99287005309	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
99287005310	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
99287005311	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
99287005312	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
99287005313	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99287005314	active site
99287005315	putative transporter; Provisional; Region: PRK11660
99287005316	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
99287005317	Sulfate transporter family; Region: Sulfate_transp; pfam00916
99287005318	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
99287005319	hypothetical protein; Provisional; Region: PRK10692
99287005320	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
99287005321	putative active site [active]
99287005322	catalytic residue [active]
99287005323	GTP-binding protein YchF; Reviewed; Region: PRK09601
99287005324	YchF GTPase; Region: YchF; cd01900
99287005325	G1 box; other site
99287005326	GTP/Mg2+ binding site [chemical binding]; other site
99287005327	Switch I region; other site
99287005328	G2 box; other site
99287005329	Switch II region; other site
99287005330	G3 box; other site
99287005331	G4 box; other site
99287005332	G5 box; other site
99287005333	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
99287005334	Protein of unknown function (DUF2743); Region: DUF2743; pfam10899
99287005335	Protein of unknown function (DUF4427); Region: DUF4427; pfam14468
99287005336	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
99287005337	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
99287005338	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
99287005339	NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720
99287005340	hydrogenase 1 large subunit; Provisional; Region: PRK10170
99287005341	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
99287005342	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
99287005343	putative substrate-binding site; other site
99287005344	nickel binding site [ion binding]; other site
99287005345	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
99287005346	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
99287005347	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
99287005348	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
99287005349	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
99287005350	hypothetical protein; Provisional; Region: PRK14749
99287005351	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
99287005352	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
99287005353	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
99287005354	NAD(P) binding site [chemical binding]; other site
99287005355	trehalase; Provisional; Region: treA; PRK13271
99287005356	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
99287005357	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
99287005358	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
99287005359	Flagellar regulator YcgR; Region: YcgR; pfam07317
99287005360	PilZ domain; Region: PilZ; pfam07238
99287005361	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
99287005362	N-acetyl-D-glucosamine binding site [chemical binding]; other site
99287005363	catalytic residue [active]
99287005364	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
99287005365	dimer interface [polypeptide binding]; other site
99287005366	catalytic triad [active]
99287005367	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
99287005368	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
99287005369	TrkA-C domain; Region: TrkA_C; pfam02080
99287005370	Transporter associated domain; Region: CorC_HlyC; smart01091
99287005371	alanine racemase; Reviewed; Region: dadX; PRK03646
99287005372	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
99287005373	active site
99287005374	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
99287005375	substrate binding site [chemical binding]; other site
99287005376	catalytic residues [active]
99287005377	dimer interface [polypeptide binding]; other site
99287005378	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
99287005379	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287005380	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287005381	SpoVR family protein; Provisional; Region: PRK11767
99287005382	fatty acid metabolism regulator; Provisional; Region: PRK04984
99287005383	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287005384	DNA-binding site [nucleotide binding]; DNA binding site
99287005385	FadR C-terminal domain; Region: FadR_C; pfam07840
99287005386	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
99287005387	disulfide bond formation protein B; Provisional; Region: PRK01749
99287005388	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
99287005389	GnsA/GnsB family; Region: GnsAB; pfam08178
99287005390	autotransport protein MisL; Provisional; Region: PRK15313
99287005391	hypothetical protein; Provisional; Region: PRK05170
99287005392	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
99287005393	hypothetical protein; Provisional; Region: PRK10691
99287005394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
99287005395	septum formation inhibitor; Reviewed; Region: minC; PRK03511
99287005396	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
99287005397	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
99287005398	cell division inhibitor MinD; Provisional; Region: PRK10818
99287005399	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
99287005400	P-loop; other site
99287005401	ADP binding residues [chemical binding]; other site
99287005402	Switch I; other site
99287005403	Switch II; other site
99287005404	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
99287005405	ribonuclease D; Provisional; Region: PRK10829
99287005406	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
99287005407	catalytic site [active]
99287005408	putative active site [active]
99287005409	putative substrate binding site [chemical binding]; other site
99287005410	HRDC domain; Region: HRDC; cl02578
99287005411	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
99287005412	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
99287005413	acyl-activating enzyme (AAE) consensus motif; other site
99287005414	putative AMP binding site [chemical binding]; other site
99287005415	putative active site [active]
99287005416	putative CoA binding site [chemical binding]; other site
99287005417	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
99287005418	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
99287005419	Glycoprotease family; Region: Peptidase_M22; pfam00814
99287005420	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
99287005421	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708
99287005422	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
99287005423	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
99287005424	homotrimer interaction site [polypeptide binding]; other site
99287005425	putative active site [active]
99287005426	hypothetical protein; Provisional; Region: PRK05114
99287005427	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
99287005428	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
99287005429	chorismate binding enzyme; Region: Chorismate_bind; cl10555
99287005430	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
99287005431	putative active site [active]
99287005432	putative CoA binding site [chemical binding]; other site
99287005433	nudix motif; other site
99287005434	metal binding site [ion binding]; metal-binding site
99287005435	L-serine deaminase; Provisional; Region: PRK15023
99287005436	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
99287005437	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
99287005438	phage resistance protein; Provisional; Region: PRK10551
99287005439	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
99287005440	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287005441	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
99287005442	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
99287005443	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
99287005444	Transporter associated domain; Region: CorC_HlyC; smart01091
99287005445	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
99287005446	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
99287005447	active pocket/dimerization site; other site
99287005448	active site
99287005449	phosphorylation site [posttranslational modification]
99287005450	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
99287005451	active site
99287005452	phosphorylation site [posttranslational modification]
99287005453	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
99287005454	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
99287005455	hypothetical protein; Provisional; Region: PRK02913
99287005456	hypothetical protein; Provisional; Region: PRK11469
99287005457	Domain of unknown function DUF; Region: DUF204; pfam02659
99287005458	Domain of unknown function DUF; Region: DUF204; pfam02659
99287005459	Methyltransferase domain; Region: Methyltransf_31; pfam13847
99287005460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287005461	S-adenosylmethionine binding site [chemical binding]; other site
99287005462	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
99287005463	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
99287005464	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
99287005465	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
99287005466	DNA-binding site [nucleotide binding]; DNA binding site
99287005467	RNA-binding motif; other site
99287005468	Protein of unknown function (DUF2627); Region: DUF2527; pfam10736
99287005469	YebO-like protein; Region: YebO; pfam13974
99287005470	PhoPQ regulatory protein; Provisional; Region: PRK10299
99287005471	YobH-like protein; Region: YobH; pfam13996
99287005472	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
99287005473	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99287005474	dimerization interface [polypeptide binding]; other site
99287005475	putative Zn2+ binding site [ion binding]; other site
99287005476	putative DNA binding site [nucleotide binding]; other site
99287005477	Bacterial transcriptional regulator; Region: IclR; pfam01614
99287005478	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287005479	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99287005480	putative substrate translocation pore; other site
99287005481	heat shock protein HtpX; Provisional; Region: PRK05457
99287005482	carboxy-terminal protease; Provisional; Region: PRK11186
99287005483	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
99287005484	protein binding site [polypeptide binding]; other site
99287005485	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
99287005486	Catalytic dyad [active]
99287005487	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
99287005488	ProP expression regulator; Provisional; Region: PRK04950
99287005489	putative RNA binding sites [nucleotide binding]; other site
99287005490	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
99287005491	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
99287005492	Paraquat-inducible protein A; Region: PqiA; pfam04403
99287005493	Paraquat-inducible protein A; Region: PqiA; pfam04403
99287005494	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
99287005495	mce related protein; Region: MCE; pfam02470
99287005496	mce related protein; Region: MCE; pfam02470
99287005497	mce related protein; Region: MCE; pfam02470
99287005498	mce related protein; Region: MCE; pfam02470
99287005499	mce related protein; Region: MCE; pfam02470
99287005500	mce related protein; Region: MCE; pfam02470
99287005501	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
99287005502	Methyltransferase domain; Region: Methyltransf_26; pfam13659
99287005503	Uncharacterized conserved protein [Function unknown]; Region: COG3270
99287005504	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
99287005505	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
99287005506	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
99287005507	type III secretion protein SopE2; Provisional; Region: PRK15280
99287005508	Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364
99287005509	SopE GEF domain; Region: SopE_GEF; pfam07487
99287005510	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
99287005511	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287005512	Coenzyme A binding pocket [chemical binding]; other site
99287005513	transposase; contains frameshifts
99287005514	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
99287005515	EamA-like transporter family; Region: EamA; pfam00892
99287005516	EamA-like transporter family; Region: EamA; pfam00892
99287005517	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
99287005518	Phage-encoded virulence factor; Region: PAGK; pfam15284
99287005519	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
99287005520	ADP-ribose binding site [chemical binding]; other site
99287005521	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
99287005522	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
99287005523	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
99287005524	Predicted chitinase [General function prediction only]; Region: COG3179
99287005525	exonuclease VIII; Reviewed; Region: PRK09709
99287005526	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
99287005527	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
99287005528	hypothetical protein; Provisional; Region: PRK10301
99287005529	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
99287005530	Predicted amidohydrolase [General function prediction only]; Region: COG0388
99287005531	exodeoxyribonuclease X; Provisional; Region: PRK07983
99287005532	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
99287005533	active site
99287005534	catalytic site [active]
99287005535	substrate binding site [chemical binding]; other site
99287005536	protease 2; Provisional; Region: PRK10115
99287005537	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
99287005538	Protein of unknown function (DUF533); Region: DUF533; pfam04391
99287005539	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
99287005540	putative metal binding site [ion binding]; other site
99287005541	hypothetical protein; Provisional; Region: PRK13680
99287005542	DNA damage-inducible protein YebG; Provisional; Region: PRK10061
99287005543	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
99287005544	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99287005545	ATP-grasp domain; Region: ATP-grasp; pfam02222
99287005546	Entner-Doudoroff aldolase; Region: eda; TIGR01182
99287005547	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
99287005548	active site
99287005549	intersubunit interface [polypeptide binding]; other site
99287005550	catalytic residue [active]
99287005551	phosphogluconate dehydratase; Validated; Region: PRK09054
99287005552	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
99287005553	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
99287005554	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
99287005555	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
99287005556	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
99287005557	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
99287005558	putative active site [active]
99287005559	pyruvate kinase; Provisional; Region: PRK05826
99287005560	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
99287005561	domain interfaces; other site
99287005562	active site
99287005563	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
99287005564	putative acyl-acceptor binding pocket; other site
99287005565	putative peptidase; Provisional; Region: PRK11649
99287005566	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
99287005567	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
99287005568	Peptidase family M23; Region: Peptidase_M23; pfam01551
99287005569	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
99287005570	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
99287005571	metal binding site [ion binding]; metal-binding site
99287005572	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
99287005573	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
99287005574	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
99287005575	ABC-ATPase subunit  interface; other site
99287005576	dimer interface [polypeptide binding]; other site
99287005577	putative PBP binding regions; other site
99287005578	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
99287005579	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287005580	Walker A motif; other site
99287005581	ATP binding site [chemical binding]; other site
99287005582	Walker B motif; other site
99287005583	arginine finger; other site
99287005584	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
99287005585	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
99287005586	RuvA N terminal domain; Region: RuvA_N; pfam01330
99287005587	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
99287005588	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
99287005589	hypothetical protein; Provisional; Region: PRK11470
99287005590	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
99287005591	active site
99287005592	putative DNA-binding cleft [nucleotide binding]; other site
99287005593	dimer interface [polypeptide binding]; other site
99287005594	hypothetical protein; Validated; Region: PRK00110
99287005595	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
99287005596	nudix motif; other site
99287005597	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
99287005598	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
99287005599	dimer interface [polypeptide binding]; other site
99287005600	anticodon binding site; other site
99287005601	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
99287005602	homodimer interface [polypeptide binding]; other site
99287005603	motif 1; other site
99287005604	active site
99287005605	motif 2; other site
99287005606	GAD domain; Region: GAD; pfam02938
99287005607	motif 3; other site
99287005608	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
99287005609	catalytic triad [active]
99287005610	conserved cis-peptide bond; other site
99287005611	hypothetical protein; Provisional; Region: PRK10302
99287005612	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
99287005613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287005614	S-adenosylmethionine binding site [chemical binding]; other site
99287005615	tRNA (mo5U34)-methyltransferase; Region: TIGR00452
99287005616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287005617	S-adenosylmethionine binding site [chemical binding]; other site
99287005618	copper homeostasis protein CutC; Provisional; Region: PRK11572
99287005619	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
99287005620	putative metal binding site [ion binding]; other site
99287005621	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
99287005622	arginyl-tRNA synthetase; Region: argS; TIGR00456
99287005623	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
99287005624	active site
99287005625	HIGH motif; other site
99287005626	KMSK motif region; other site
99287005627	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
99287005628	tRNA binding surface [nucleotide binding]; other site
99287005629	anticodon binding site; other site
99287005630	penicillin-binding protein 2; Provisional; Region: PRK10795
99287005631	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
99287005632	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
99287005633	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
99287005634	Flagellar protein FlhE; Region: FlhE; pfam06366
99287005635	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
99287005636	FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167
99287005637	chemotaxis regulator CheZ; Provisional; Region: PRK11166
99287005638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287005639	active site
99287005640	phosphorylation site [posttranslational modification]
99287005641	intermolecular recognition site; other site
99287005642	dimerization interface [polypeptide binding]; other site
99287005643	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
99287005644	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287005645	active site
99287005646	phosphorylation site [posttranslational modification]
99287005647	intermolecular recognition site; other site
99287005648	dimerization interface [polypeptide binding]; other site
99287005649	CheB methylesterase; Region: CheB_methylest; pfam01339
99287005650	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
99287005651	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
99287005652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287005653	S-adenosylmethionine binding site [chemical binding]; other site
99287005654	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
99287005655	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
99287005656	dimer interface [polypeptide binding]; other site
99287005657	ligand binding site [chemical binding]; other site
99287005658	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287005659	dimerization interface [polypeptide binding]; other site
99287005660	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
99287005661	dimer interface [polypeptide binding]; other site
99287005662	putative CheW interface [polypeptide binding]; other site
99287005663	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
99287005664	putative CheA interaction surface; other site
99287005665	chemotaxis protein CheA; Provisional; Region: PRK10547
99287005666	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
99287005667	putative binding surface; other site
99287005668	active site
99287005669	CheY binding; Region: CheY-binding; pfam09078
99287005670	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
99287005671	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287005672	ATP binding site [chemical binding]; other site
99287005673	Mg2+ binding site [ion binding]; other site
99287005674	G-X-G motif; other site
99287005675	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
99287005676	flagellar motor protein MotB; Validated; Region: motB; PRK09041
99287005677	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
99287005678	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
99287005679	ligand binding site [chemical binding]; other site
99287005680	flagellar motor protein MotA; Validated; Region: PRK09110
99287005681	transcriptional activator FlhC; Provisional; Region: PRK12722
99287005682	transcriptional activator FlhD; Provisional; Region: PRK02909
99287005683	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99287005684	Ligand Binding Site [chemical binding]; other site
99287005685	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
99287005686	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
99287005687	active site
99287005688	homotetramer interface [polypeptide binding]; other site
99287005689	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287005690	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
99287005691	active site
99287005692	motif I; other site
99287005693	motif II; other site
99287005694	DJ-1 family protein; Region: not_thiJ; TIGR01383
99287005695	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
99287005696	conserved cys residue [active]
99287005697	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
99287005698	Ferritin-like domain; Region: Ferritin; pfam00210
99287005699	ferroxidase diiron center [ion binding]; other site
99287005700	hypothetical protein; Provisional; Region: PRK09273
99287005701	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
99287005702	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
99287005703	YecR-like lipoprotein; Region: YecR; pfam13992
99287005704	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
99287005705	Ferritin-like domain; Region: Ferritin; pfam00210
99287005706	ferroxidase diiron center [ion binding]; other site
99287005707	probable metal-binding protein; Region: matur_matur; TIGR03853
99287005708	tyrosine transporter TyrP; Provisional; Region: PRK15132
99287005709	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
99287005710	hypothetical protein; Provisional; Region: PRK10396
99287005711	yecA family protein; Region: ygfB_yecA; TIGR02292
99287005712	SEC-C motif; Region: SEC-C; pfam02810
99287005713	glucose-6-phosphate 1-dehydrogenase; Region: PLN02640
99287005714	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
99287005715	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
99287005716	NlpC/P60 family; Region: NLPC_P60; cl17555
99287005717	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
99287005718	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
99287005719	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
99287005720	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
99287005721	GIY-YIG motif/motif A; other site
99287005722	active site
99287005723	catalytic site [active]
99287005724	putative DNA binding site [nucleotide binding]; other site
99287005725	metal binding site [ion binding]; metal-binding site
99287005726	UvrB/uvrC motif; Region: UVR; pfam02151
99287005727	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
99287005728	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
99287005729	response regulator; Provisional; Region: PRK09483
99287005730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287005731	active site
99287005732	phosphorylation site [posttranslational modification]
99287005733	intermolecular recognition site; other site
99287005734	dimerization interface [polypeptide binding]; other site
99287005735	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287005736	DNA binding residues [nucleotide binding]
99287005737	dimerization interface [polypeptide binding]; other site
99287005738	hypothetical protein; Provisional; Region: PRK10613
99287005739	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
99287005740	Autoinducer binding domain; Region: Autoind_bind; pfam03472
99287005741	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287005742	DNA binding residues [nucleotide binding]
99287005743	dimerization interface [polypeptide binding]; other site
99287005744	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
99287005745	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
99287005746	Walker A/P-loop; other site
99287005747	ATP binding site [chemical binding]; other site
99287005748	Q-loop/lid; other site
99287005749	ABC transporter signature motif; other site
99287005750	Walker B; other site
99287005751	D-loop; other site
99287005752	H-loop/switch region; other site
99287005753	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
99287005754	amino acid ABC transporter permease; Provisional; Region: PRK15100
99287005755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287005756	dimer interface [polypeptide binding]; other site
99287005757	conserved gate region; other site
99287005758	putative PBP binding loops; other site
99287005759	ABC-ATPase subunit interface; other site
99287005760	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
99287005761	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287005762	catalytic residue [active]
99287005763	cystine transporter subunit; Provisional; Region: PRK11260
99287005764	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287005765	substrate binding pocket [chemical binding]; other site
99287005766	membrane-bound complex binding site; other site
99287005767	hinge residues; other site
99287005768	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
99287005769	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
99287005770	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99287005771	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
99287005772	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99287005773	DNA binding residues [nucleotide binding]
99287005774	Transposase IS200 like; Region: Y1_Tnp; pfam01797
99287005775	flagellin; Validated; Region: PRK08026
99287005776	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
99287005777	Flagellin D3 domain; Region: Flagellin_D3; pfam08884
99287005778	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
99287005779	flagellar capping protein; Reviewed; Region: fliD; PRK08032
99287005780	Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465
99287005781	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
99287005782	flagellar protein FliS; Validated; Region: fliS; PRK05685
99287005783	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
99287005784	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
99287005785	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
99287005786	active site
99287005787	Na/Ca binding site [ion binding]; other site
99287005788	catalytic site [active]
99287005789	lipoprotein; Provisional; Region: PRK10397
99287005790	putative inner membrane protein; Provisional; Region: PRK11099
99287005791	Predicted transporter component [General function prediction only]; Region: COG2391
99287005792	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
99287005793	CPxP  motif; other site
99287005794	longest chromosomal non-coding region
99287005795	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
99287005796	flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206
99287005797	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
99287005798	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
99287005799	flagellar motor switch protein FliG; Region: fliG; TIGR00207
99287005800	FliG N-terminal domain; Region: FliG_N; pfam14842
99287005801	FliG middle domain; Region: FliG_M; pfam14841
99287005802	FliG C-terminal domain; Region: FliG_C; pfam01706
99287005803	flagellar assembly protein H; Validated; Region: fliH; PRK05687
99287005804	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
99287005805	Flagellar assembly protein FliH; Region: FliH; pfam02108
99287005806	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
99287005807	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
99287005808	Walker A motif/ATP binding site; other site
99287005809	Walker B motif; other site
99287005810	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
99287005811	flagellar hook-length control protein; Provisional; Region: PRK10118
99287005812	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
99287005813	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
99287005814	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
99287005815	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
99287005816	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
99287005817	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
99287005818	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
99287005819	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
99287005820	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
99287005821	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
99287005822	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287005823	DNA binding residues [nucleotide binding]
99287005824	dimerization interface [polypeptide binding]; other site
99287005825	hypothetical protein; Provisional; Region: PRK10708
99287005826	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
99287005827	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
99287005828	mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486
99287005829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287005830	active site
99287005831	motif I; other site
99287005832	motif II; other site
99287005833	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
99287005834	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99287005835	metal binding site [ion binding]; metal-binding site
99287005836	active site
99287005837	I-site; other site
99287005838	Uncharacterized small protein [Function unknown]; Region: COG5475
99287005839	hypothetical protein; Provisional; Region: PRK10062
99287005840	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
99287005841	EamA-like transporter family; Region: EamA; pfam00892
99287005842	EamA-like transporter family; Region: EamA; pfam00892
99287005843	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
99287005844	additional DNA contacts [nucleotide binding]; other site
99287005845	mismatch recognition site; other site
99287005846	active site
99287005847	zinc binding site [ion binding]; other site
99287005848	DNA intercalation site [nucleotide binding]; other site
99287005849	DNA cytosine methylase; Provisional; Region: PRK10458
99287005850	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
99287005851	cofactor binding site; other site
99287005852	DNA binding site [nucleotide binding]
99287005853	substrate interaction site [chemical binding]; other site
99287005854	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
99287005855	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
99287005856	Zn2+ binding site [ion binding]; other site
99287005857	Mg2+ binding site [ion binding]; other site
99287005858	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
99287005859	trimer interface [polypeptide binding]; other site
99287005860	eyelet of channel; other site
99287005861	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
99287005862	DNA-binding site [nucleotide binding]; DNA binding site
99287005863	RNA-binding motif; other site
99287005864	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
99287005865	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
99287005866	active site
99287005867	DNA binding site [nucleotide binding]
99287005868	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
99287005869	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
99287005870	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
99287005871	Catalytic site [active]
99287005872	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
99287005873	putative protease; Region: PHA00666
99287005874	integrase; contains framshift
99287005875	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
99287005876	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
99287005877	Sel1 repeat; Region: Sel1; pfam08238
99287005878	Sel1-like repeats; Region: SEL1; smart00671
99287005879	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
99287005880	AMP nucleosidase; Provisional; Region: PRK08292
99287005881	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
99287005882	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
99287005883	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
99287005884	MATE family multidrug exporter; Provisional; Region: PRK10189
99287005885	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
99287005886	L,D-transpeptidase; Provisional; Region: PRK10190
99287005887	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
99287005888	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
99287005889	putative dimer interface [polypeptide binding]; other site
99287005890	active site pocket [active]
99287005891	putative cataytic base [active]
99287005892	cobalamin synthase; Reviewed; Region: cobS; PRK00235
99287005893	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
99287005894	homotrimer interface [polypeptide binding]; other site
99287005895	Walker A motif; other site
99287005896	GTP binding site [chemical binding]; other site
99287005897	Walker B motif; other site
99287005898	cobyric acid synthase; Provisional; Region: PRK00784
99287005899	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99287005900	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
99287005901	catalytic triad [active]
99287005902	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
99287005903	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
99287005904	Walker A/P-loop; other site
99287005905	ATP binding site [chemical binding]; other site
99287005906	Q-loop/lid; other site
99287005907	ABC transporter signature motif; other site
99287005908	Walker B; other site
99287005909	D-loop; other site
99287005910	H-loop/switch region; other site
99287005911	cobalt transport protein CbiQ; Provisional; Region: PRK15485
99287005912	cobalt transport protein CbiN; Provisional; Region: PRK02898
99287005913	cobalt transport protein CbiM; Validated; Region: PRK08319
99287005914	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
99287005915	active site
99287005916	SAM binding site [chemical binding]; other site
99287005917	homodimer interface [polypeptide binding]; other site
99287005918	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
99287005919	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
99287005920	active site
99287005921	C-terminal domain interface [polypeptide binding]; other site
99287005922	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
99287005923	active site
99287005924	N-terminal domain interface [polypeptide binding]; other site
99287005925	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
99287005926	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
99287005927	active site
99287005928	SAM binding site [chemical binding]; other site
99287005929	homodimer interface [polypeptide binding]; other site
99287005930	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
99287005931	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
99287005932	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
99287005933	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
99287005934	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
99287005935	active site
99287005936	SAM binding site [chemical binding]; other site
99287005937	homodimer interface [polypeptide binding]; other site
99287005938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287005939	S-adenosylmethionine binding site [chemical binding]; other site
99287005940	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
99287005941	active site
99287005942	putative homodimer interface [polypeptide binding]; other site
99287005943	SAM binding site [chemical binding]; other site
99287005944	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
99287005945	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
99287005946	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
99287005947	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
99287005948	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99287005949	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
99287005950	catalytic triad [active]
99287005951	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
99287005952	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287005953	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99287005954	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287005955	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
99287005956	amphipathic channel; other site
99287005957	Asn-Pro-Ala signature motifs; other site
99287005958	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
99287005959	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
99287005960	Hexamer interface [polypeptide binding]; other site
99287005961	Hexagonal pore residue; other site
99287005962	propanediol utilization protein PduB; Provisional; Region: PRK15415
99287005963	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
99287005964	putative hexamer interface [polypeptide binding]; other site
99287005965	putative hexagonal pore; other site
99287005966	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
99287005967	putative hexamer interface [polypeptide binding]; other site
99287005968	putative hexagonal pore; other site
99287005969	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
99287005970	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
99287005971	alpha-beta subunit interface [polypeptide binding]; other site
99287005972	alpha-gamma subunit interface [polypeptide binding]; other site
99287005973	active site
99287005974	substrate and K+ binding site; other site
99287005975	K+ binding site [ion binding]; other site
99287005976	cobalamin binding site [chemical binding]; other site
99287005977	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
99287005978	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
99287005979	Cell division protein FtsA; Region: FtsA; cl17206
99287005980	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
99287005981	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
99287005982	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
99287005983	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
99287005984	Hexamer interface [polypeptide binding]; other site
99287005985	Hexagonal pore residue; other site
99287005986	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
99287005987	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
99287005988	putative hexamer interface [polypeptide binding]; other site
99287005989	putative hexagonal pore; other site
99287005990	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
99287005991	Propanediol utilisation protein PduL; Region: PduL; pfam06130
99287005992	Propanediol utilisation protein PduL; Region: PduL; pfam06130
99287005993	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
99287005994	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
99287005995	Hexamer/Pentamer interface [polypeptide binding]; other site
99287005996	central pore; other site
99287005997	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
99287005998	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
99287005999	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
99287006000	putative catalytic cysteine [active]
99287006001	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
99287006002	putative active site [active]
99287006003	metal binding site [ion binding]; metal-binding site
99287006004	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
99287006005	SLBB domain; Region: SLBB; pfam10531
99287006006	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
99287006007	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
99287006008	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
99287006009	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
99287006010	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
99287006011	putative hexamer interface [polypeptide binding]; other site
99287006012	putative hexagonal pore; other site
99287006013	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
99287006014	putative hexamer interface [polypeptide binding]; other site
99287006015	putative hexagonal pore; other site
99287006016	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
99287006017	putative hexamer interface [polypeptide binding]; other site
99287006018	putative hexagonal pore; other site
99287006019	Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662
99287006020	G3 box; other site
99287006021	Switch II region; other site
99287006022	GTP/Mg2+ binding site [chemical binding]; other site
99287006023	G4 box; other site
99287006024	G5 box; other site
99287006025	propionate kinase; Reviewed; Region: PRK12397
99287006026	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
99287006027	hypothetical protein; Provisional; Region: PRK05423
99287006028	Predicted membrane protein [Function unknown]; Region: COG1289
99287006029	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
99287006030	DNA gyrase inhibitor; Provisional; Region: PRK10016
99287006031	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
99287006032	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
99287006033	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
99287006034	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
99287006035	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
99287006036	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
99287006037	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287006038	thiosulfate reductase PhsA; Provisional; Region: PRK15488
99287006039	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
99287006040	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
99287006041	putative [Fe4-S4] binding site [ion binding]; other site
99287006042	putative molybdopterin cofactor binding site [chemical binding]; other site
99287006043	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
99287006044	putative molybdopterin cofactor binding site; other site
99287006045	E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377
99287006046	SopA-like central domain; Region: SopA; pfam13981
99287006047	SopA-like catalytic domain; Region: SopA_C; pfam13979
99287006048	exonuclease I; Provisional; Region: sbcB; PRK11779
99287006049	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
99287006050	active site
99287006051	catalytic site [active]
99287006052	substrate binding site [chemical binding]; other site
99287006053	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
99287006054	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
99287006055	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
99287006056	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287006057	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
99287006058	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287006059	dimerization interface [polypeptide binding]; other site
99287006060	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
99287006061	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
99287006062	putative NAD(P) binding site [chemical binding]; other site
99287006063	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
99287006064	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
99287006065	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
99287006066	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
99287006067	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
99287006068	NAD binding site [chemical binding]; other site
99287006069	dimerization interface [polypeptide binding]; other site
99287006070	product binding site; other site
99287006071	substrate binding site [chemical binding]; other site
99287006072	zinc binding site [ion binding]; other site
99287006073	catalytic residues [active]
99287006074	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
99287006075	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99287006076	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287006077	homodimer interface [polypeptide binding]; other site
99287006078	catalytic residue [active]
99287006079	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
99287006080	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287006081	active site
99287006082	motif I; other site
99287006083	motif II; other site
99287006084	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
99287006085	putative active site pocket [active]
99287006086	4-fold oligomerization interface [polypeptide binding]; other site
99287006087	metal binding residues [ion binding]; metal-binding site
99287006088	3-fold/trimer interface [polypeptide binding]; other site
99287006089	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
99287006090	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
99287006091	putative active site [active]
99287006092	oxyanion strand; other site
99287006093	catalytic triad [active]
99287006094	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
99287006095	catalytic residues [active]
99287006096	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
99287006097	substrate binding site [chemical binding]; other site
99287006098	glutamase interaction surface [polypeptide binding]; other site
99287006099	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
99287006100	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
99287006101	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
99287006102	metal binding site [ion binding]; metal-binding site
99287006103	chain length determinant protein WzzB; Provisional; Region: PRK15471
99287006104	Chain length determinant protein; Region: Wzz; pfam02706
99287006105	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
99287006106	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
99287006107	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
99287006108	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
99287006109	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
99287006110	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
99287006111	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
99287006112	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
99287006113	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
99287006114	CoA binding domain; Region: CoA_binding; cl17356
99287006115	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
99287006116	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
99287006117	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
99287006118	active site
99287006119	substrate binding site [chemical binding]; other site
99287006120	metal binding site [ion binding]; metal-binding site
99287006121	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
99287006122	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
99287006123	Substrate binding site; other site
99287006124	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
99287006125	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
99287006126	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
99287006127	active site
99287006128	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99287006129	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99287006130	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
99287006131	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
99287006132	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
99287006133	active site
99287006134	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
99287006135	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
99287006136	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99287006137	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
99287006138	NAD(P) binding site [chemical binding]; other site
99287006139	active site
99287006140	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
99287006141	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
99287006142	inhibitor-cofactor binding pocket; inhibition site
99287006143	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287006144	catalytic residue [active]
99287006145	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
99287006146	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
99287006147	NAD binding site [chemical binding]; other site
99287006148	homotetramer interface [polypeptide binding]; other site
99287006149	homodimer interface [polypeptide binding]; other site
99287006150	substrate binding site [chemical binding]; other site
99287006151	active site
99287006152	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
99287006153	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
99287006154	substrate binding site; other site
99287006155	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
99287006156	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99287006157	catalytic loop [active]
99287006158	iron binding site [ion binding]; other site
99287006159	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
99287006160	FAD binding pocket [chemical binding]; other site
99287006161	FAD binding motif [chemical binding]; other site
99287006162	phosphate binding motif [ion binding]; other site
99287006163	beta-alpha-beta structure motif; other site
99287006164	NAD binding pocket [chemical binding]; other site
99287006165	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
99287006166	glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480
99287006167	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
99287006168	substrate binding site; other site
99287006169	tetramer interface; other site
99287006170	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
99287006171	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
99287006172	NADP binding site [chemical binding]; other site
99287006173	active site
99287006174	putative substrate binding site [chemical binding]; other site
99287006175	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
99287006176	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
99287006177	NAD binding site [chemical binding]; other site
99287006178	substrate binding site [chemical binding]; other site
99287006179	homodimer interface [polypeptide binding]; other site
99287006180	active site
99287006181	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
99287006182	active site
99287006183	tetramer interface; other site
99287006184	colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004
99287006185	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
99287006186	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
99287006187	putative ADP-binding pocket [chemical binding]; other site
99287006188	colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006
99287006189	colanic acid exporter; Provisional; Region: PRK10459
99287006190	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
99287006191	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
99287006192	CoA-binding domain; Region: CoA_binding_3; pfam13727
99287006193	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
99287006194	phosphomannomutase CpsG; Provisional; Region: PRK15414
99287006195	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
99287006196	active site
99287006197	substrate binding site [chemical binding]; other site
99287006198	metal binding site [ion binding]; metal-binding site
99287006199	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
99287006200	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
99287006201	Substrate binding site; other site
99287006202	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
99287006203	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
99287006204	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
99287006205	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
99287006206	active site
99287006207	GDP-Mannose binding site [chemical binding]; other site
99287006208	dimer interface [polypeptide binding]; other site
99287006209	modified nudix motif
99287006210	metal binding site [ion binding]; metal-binding site
99287006211	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
99287006212	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
99287006213	NADP binding site [chemical binding]; other site
99287006214	active site
99287006215	putative substrate binding site [chemical binding]; other site
99287006216	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
99287006217	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
99287006218	NADP-binding site; other site
99287006219	homotetramer interface [polypeptide binding]; other site
99287006220	substrate binding site [chemical binding]; other site
99287006221	homodimer interface [polypeptide binding]; other site
99287006222	active site
99287006223	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
99287006224	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
99287006225	putative trimer interface [polypeptide binding]; other site
99287006226	putative active site [active]
99287006227	putative substrate binding site [chemical binding]; other site
99287006228	putative CoA binding site [chemical binding]; other site
99287006229	colanic acid biosynthesis glycosyl transferase WcaE; Region: wcaE; TIGR04009
99287006230	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
99287006231	metal-binding site
99287006232	putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075
99287006233	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
99287006234	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99287006235	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
99287006236	putative acyl transferase; Provisional; Region: PRK10191
99287006237	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
99287006238	trimer interface [polypeptide binding]; other site
99287006239	active site
99287006240	substrate binding site [chemical binding]; other site
99287006241	CoA binding site [chemical binding]; other site
99287006242	putative glycosyl transferase; Provisional; Region: PRK10018
99287006243	colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017
99287006244	active site
99287006245	tyrosine kinase; Provisional; Region: PRK11519
99287006246	Chain length determinant protein; Region: Wzz; pfam02706
99287006247	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
99287006248	AAA domain; Region: AAA_31; pfam13614
99287006249	Low molecular weight phosphatase family; Region: LMWPc; cd00115
99287006250	active site
99287006251	polysaccharide export protein Wza; Provisional; Region: PRK15078
99287006252	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
99287006253	SLBB domain; Region: SLBB; pfam10531
99287006254	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
99287006255	FOG: CBS domain [General function prediction only]; Region: COG0517
99287006256	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
99287006257	Transporter associated domain; Region: CorC_HlyC; smart01091
99287006258	putative assembly protein; Provisional; Region: PRK10833
99287006259	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
99287006260	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
99287006261	trimer interface [polypeptide binding]; other site
99287006262	active site
99287006263	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
99287006264	ATP-binding site [chemical binding]; other site
99287006265	Sugar specificity; other site
99287006266	Pyrimidine base specificity; other site
99287006267	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
99287006268	putative diguanylate cyclase; Provisional; Region: PRK09776
99287006269	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99287006270	putative active site [active]
99287006271	heme pocket [chemical binding]; other site
99287006272	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99287006273	putative active site [active]
99287006274	heme pocket [chemical binding]; other site
99287006275	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99287006276	metal binding site [ion binding]; metal-binding site
99287006277	active site
99287006278	I-site; other site
99287006279	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287006280	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
99287006281	AlkA N-terminal domain; Region: AlkA_N; pfam06029
99287006282	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
99287006283	minor groove reading motif; other site
99287006284	helix-hairpin-helix signature motif; other site
99287006285	substrate binding pocket [chemical binding]; other site
99287006286	active site
99287006287	putative chaperone; Provisional; Region: PRK11678
99287006288	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
99287006289	nucleotide binding site [chemical binding]; other site
99287006290	putative NEF/HSP70 interaction site [polypeptide binding]; other site
99287006291	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
99287006292	SBD interface [polypeptide binding]; other site
99287006293	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
99287006294	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99287006295	HlyD family secretion protein; Region: HlyD_3; pfam13437
99287006296	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
99287006297	MMPL family; Region: MMPL; cl14618
99287006298	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
99287006299	MMPL family; Region: MMPL; cl14618
99287006300	putative transporter; Provisional; Region: PRK10504
99287006301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287006302	putative substrate translocation pore; other site
99287006303	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
99287006304	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287006305	dimerization interface [polypeptide binding]; other site
99287006306	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287006307	dimer interface [polypeptide binding]; other site
99287006308	phosphorylation site [posttranslational modification]
99287006309	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287006310	ATP binding site [chemical binding]; other site
99287006311	Mg2+ binding site [ion binding]; other site
99287006312	G-X-G motif; other site
99287006313	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
99287006314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287006315	active site
99287006316	phosphorylation site [posttranslational modification]
99287006317	intermolecular recognition site; other site
99287006318	dimerization interface [polypeptide binding]; other site
99287006319	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287006320	DNA binding site [nucleotide binding]
99287006321	PcfJ-like protein; Region: PcfJ; pfam14284
99287006322	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
99287006323	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
99287006324	putative protease; Provisional; Region: PRK15452
99287006325	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
99287006326	type III secretion system protein; Provisional; Region: PRK15383
99287006327	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
99287006328	lipid kinase; Reviewed; Region: PRK13054
99287006329	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
99287006330	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
99287006331	putative active site; other site
99287006332	catalytic residue [active]
99287006333	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
99287006334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287006335	putative substrate translocation pore; other site
99287006336	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
99287006337	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
99287006338	substrate binding site [chemical binding]; other site
99287006339	ATP binding site [chemical binding]; other site
99287006340	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
99287006341	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287006342	DNA-binding site [nucleotide binding]; DNA binding site
99287006343	UTRA domain; Region: UTRA; pfam07702
99287006344	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
99287006345	dimer interface [polypeptide binding]; other site
99287006346	substrate binding site [chemical binding]; other site
99287006347	ATP binding site [chemical binding]; other site
99287006348	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
99287006349	substrate binding site [chemical binding]; other site
99287006350	multimerization interface [polypeptide binding]; other site
99287006351	ATP binding site [chemical binding]; other site
99287006352	Predicted integral membrane protein [Function unknown]; Region: COG5455
99287006353	putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252
99287006354	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
99287006355	PapC N-terminal domain; Region: PapC_N; pfam13954
99287006356	Outer membrane usher protein; Region: Usher; pfam00577
99287006357	PapC C-terminal domain; Region: PapC_C; pfam13953
99287006358	putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253
99287006359	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287006360	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287006361	fimbrial chaperone protein; Provisional; Region: PRK15220
99287006362	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
99287006363	antiporter inner membrane protein; Provisional; Region: PRK11670
99287006364	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
99287006365	Walker A motif; other site
99287006366	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
99287006367	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
99287006368	active site
99287006369	HIGH motif; other site
99287006370	KMSKS motif; other site
99287006371	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
99287006372	tRNA binding surface [nucleotide binding]; other site
99287006373	anticodon binding site; other site
99287006374	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
99287006375	dimer interface [polypeptide binding]; other site
99287006376	putative tRNA-binding site [nucleotide binding]; other site
99287006377	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
99287006378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
99287006379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
99287006380	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
99287006381	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
99287006382	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
99287006383	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287006384	active site
99287006385	phosphorylation site [posttranslational modification]
99287006386	intermolecular recognition site; other site
99287006387	dimerization interface [polypeptide binding]; other site
99287006388	LytTr DNA-binding domain; Region: LytTR; pfam04397
99287006389	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
99287006390	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
99287006391	GAF domain; Region: GAF; pfam01590
99287006392	Histidine kinase; Region: His_kinase; pfam06580
99287006393	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287006394	ATP binding site [chemical binding]; other site
99287006395	Mg2+ binding site [ion binding]; other site
99287006396	G-X-G motif; other site
99287006397	transcriptional regulator MirA; Provisional; Region: PRK15043
99287006398	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
99287006399	DNA binding residues [nucleotide binding]
99287006400	hypothetical protein; Provisional; Region: PRK13681
99287006401	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287006402	dimer interface [polypeptide binding]; other site
99287006403	conserved gate region; other site
99287006404	putative PBP binding loops; other site
99287006405	ABC-ATPase subunit interface; other site
99287006406	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
99287006407	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287006408	Walker A/P-loop; other site
99287006409	ATP binding site [chemical binding]; other site
99287006410	Q-loop/lid; other site
99287006411	ABC transporter signature motif; other site
99287006412	Walker B; other site
99287006413	D-loop; other site
99287006414	H-loop/switch region; other site
99287006415	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
99287006416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287006417	dimer interface [polypeptide binding]; other site
99287006418	conserved gate region; other site
99287006419	putative PBP binding loops; other site
99287006420	ABC-ATPase subunit interface; other site
99287006421	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
99287006422	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
99287006423	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
99287006424	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
99287006425	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
99287006426	D-lactate dehydrogenase; Provisional; Region: PRK11183
99287006427	FAD binding domain; Region: FAD_binding_4; cl19922
99287006428	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
99287006429	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
99287006430	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
99287006431	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
99287006432	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
99287006433	oxidoreductase; Provisional; Region: PRK12743
99287006434	classical (c) SDRs; Region: SDR_c; cd05233
99287006435	NAD(P) binding site [chemical binding]; other site
99287006436	active site
99287006437	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
99287006438	Outer membrane efflux protein; Region: OEP; pfam02321
99287006439	Outer membrane efflux protein; Region: OEP; pfam02321
99287006440	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
99287006441	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
99287006442	FMN binding site [chemical binding]; other site
99287006443	active site
99287006444	catalytic residues [active]
99287006445	substrate binding site [chemical binding]; other site
99287006446	salicylate hydroxylase; Provisional; Region: PRK08163
99287006447	Squalene epoxidase; Region: SE; cl17314
99287006448	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
99287006449	maleylacetoacetate isomerase; Region: maiA; TIGR01262
99287006450	C-terminal domain interface [polypeptide binding]; other site
99287006451	GSH binding site (G-site) [chemical binding]; other site
99287006452	putative dimer interface [polypeptide binding]; other site
99287006453	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
99287006454	dimer interface [polypeptide binding]; other site
99287006455	N-terminal domain interface [polypeptide binding]; other site
99287006456	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
99287006457	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
99287006458	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
99287006459	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
99287006460	Cupin domain; Region: Cupin_2; pfam07883
99287006461	Cupin domain; Region: Cupin_2; cl17218
99287006462	benzoate transport; Region: 2A0115; TIGR00895
99287006463	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287006464	putative substrate translocation pore; other site
99287006465	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
99287006466	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287006467	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287006468	dimerization interface [polypeptide binding]; other site
99287006469	hypothetical protein; Provisional; Region: PRK01821
99287006470	hypothetical protein; Provisional; Region: PRK10711
99287006471	cytidine deaminase; Provisional; Region: PRK09027
99287006472	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
99287006473	active site
99287006474	catalytic motif [active]
99287006475	Zn binding site [ion binding]; other site
99287006476	Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211
99287006477	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
99287006478	active site
99287006479	catalytic motif [active]
99287006480	Zn binding site [ion binding]; other site
99287006481	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
99287006482	putative active site [active]
99287006483	Protein of unknown function (DUF2542); Region: DUF2542; pfam10808
99287006484	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
99287006485	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
99287006486	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287006487	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99287006488	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
99287006489	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
99287006490	homodimer interface [polypeptide binding]; other site
99287006491	active site
99287006492	FMN binding site [chemical binding]; other site
99287006493	substrate binding site [chemical binding]; other site
99287006494	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287006495	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
99287006496	TM-ABC transporter signature motif; other site
99287006497	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
99287006498	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
99287006499	Walker A/P-loop; other site
99287006500	ATP binding site [chemical binding]; other site
99287006501	Q-loop/lid; other site
99287006502	ABC transporter signature motif; other site
99287006503	Walker B; other site
99287006504	D-loop; other site
99287006505	H-loop/switch region; other site
99287006506	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
99287006507	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
99287006508	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
99287006509	ligand binding site [chemical binding]; other site
99287006510	calcium binding site [ion binding]; other site
99287006511	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
99287006512	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287006513	DNA binding site [nucleotide binding]
99287006514	domain linker motif; other site
99287006515	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
99287006516	dimerization interface (closed form) [polypeptide binding]; other site
99287006517	ligand binding site [chemical binding]; other site
99287006518	Predicted membrane protein [Function unknown]; Region: COG2311
99287006519	hypothetical protein; Provisional; Region: PRK10835
99287006520	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
99287006521	homodecamer interface [polypeptide binding]; other site
99287006522	active site
99287006523	putative catalytic site residues [active]
99287006524	zinc binding site [ion binding]; other site
99287006525	GTP-CH-I/GFRP interaction surface; other site
99287006526	Predicted esterase [General function prediction only]; Region: COG0627
99287006527	S-formylglutathione hydrolase; Region: PLN02442
99287006528	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
99287006529	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287006530	non-specific DNA binding site [nucleotide binding]; other site
99287006531	salt bridge; other site
99287006532	sequence-specific DNA binding site [nucleotide binding]; other site
99287006533	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
99287006534	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
99287006535	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
99287006536	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
99287006537	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
99287006538	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287006539	motif II; other site
99287006540	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
99287006541	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287006542	putative substrate translocation pore; other site
99287006543	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
99287006544	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99287006545	N-terminal plug; other site
99287006546	ligand-binding site [chemical binding]; other site
99287006547	lysine transporter; Provisional; Region: PRK10836
99287006548	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
99287006549	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
99287006550	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287006551	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
99287006552	putative dimerization interface [polypeptide binding]; other site
99287006553	conserved hypothetical integral membrane protein; Region: TIGR00698
99287006554	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
99287006555	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
99287006556	AP (apurinic/apyrimidinic) site pocket; other site
99287006557	DNA interaction; other site
99287006558	Metal-binding active site; metal-binding site
99287006559	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
99287006560	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
99287006561	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
99287006562	active site
99287006563	P-loop; other site
99287006564	phosphorylation site [posttranslational modification]
99287006565	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
99287006566	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
99287006567	putative substrate binding site [chemical binding]; other site
99287006568	putative ATP binding site [chemical binding]; other site
99287006569	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
99287006570	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
99287006571	active site
99287006572	phosphorylation site [posttranslational modification]
99287006573	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
99287006574	dimerization domain swap beta strand [polypeptide binding]; other site
99287006575	regulatory protein interface [polypeptide binding]; other site
99287006576	active site
99287006577	regulatory phosphorylation site [posttranslational modification]; other site
99287006578	sugar efflux transporter B; Provisional; Region: PRK15011
99287006579	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287006580	putative substrate translocation pore; other site
99287006581	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
99287006582	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
99287006583	elongation factor P; Provisional; Region: PRK04542
99287006584	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
99287006585	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
99287006586	RNA binding site [nucleotide binding]; other site
99287006587	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
99287006588	RNA binding site [nucleotide binding]; other site
99287006589	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
99287006590	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
99287006591	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
99287006592	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
99287006593	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
99287006594	active site
99287006595	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
99287006596	NlpC/P60 family; Region: NLPC_P60; pfam00877
99287006597	phage resistance protein; Provisional; Region: PRK10551
99287006598	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
99287006599	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287006600	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
99287006601	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
99287006602	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
99287006603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287006604	dimer interface [polypeptide binding]; other site
99287006605	conserved gate region; other site
99287006606	putative PBP binding loops; other site
99287006607	ABC-ATPase subunit interface; other site
99287006608	microcin C ABC transporter permease; Provisional; Region: PRK15021
99287006609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287006610	dimer interface [polypeptide binding]; other site
99287006611	conserved gate region; other site
99287006612	putative PBP binding loops; other site
99287006613	ABC-ATPase subunit interface; other site
99287006614	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
99287006615	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99287006616	Walker A/P-loop; other site
99287006617	ATP binding site [chemical binding]; other site
99287006618	Q-loop/lid; other site
99287006619	ABC transporter signature motif; other site
99287006620	Walker B; other site
99287006621	D-loop; other site
99287006622	H-loop/switch region; other site
99287006623	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
99287006624	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99287006625	Walker A/P-loop; other site
99287006626	ATP binding site [chemical binding]; other site
99287006627	Q-loop/lid; other site
99287006628	ABC transporter signature motif; other site
99287006629	Walker B; other site
99287006630	D-loop; other site
99287006631	H-loop/switch region; other site
99287006632	hypothetical protein; Provisional; Region: PRK11835
99287006633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287006634	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
99287006635	putative substrate translocation pore; other site
99287006636	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
99287006637	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99287006638	RNA binding surface [nucleotide binding]; other site
99287006639	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
99287006640	active site
99287006641	uracil binding [chemical binding]; other site
99287006642	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
99287006643	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99287006644	ATP binding site [chemical binding]; other site
99287006645	putative Mg++ binding site [ion binding]; other site
99287006646	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287006647	nucleotide binding region [chemical binding]; other site
99287006648	ATP-binding site [chemical binding]; other site
99287006649	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
99287006650	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
99287006651	5S rRNA interface [nucleotide binding]; other site
99287006652	CTC domain interface [polypeptide binding]; other site
99287006653	L16 interface [polypeptide binding]; other site
99287006654	nucleoid-associated protein NdpA; Validated; Region: PRK00378
99287006655	hypothetical protein; Provisional; Region: PRK13689
99287006656	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
99287006657	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
99287006658	Sulfatase; Region: Sulfatase; cl19157
99287006659	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
99287006660	Catalytic site [active]
99287006661	DinI-like family; Region: DinI; cl11630
99287006662	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
99287006663	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
99287006664	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
99287006665	Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903
99287006666	Phage head maturation protease [General function prediction only]; Region: COG3740
99287006667	Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938
99287006668	Phage portal protein; Region: Phage_portal; cl19194
99287006669	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
99287006670	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
99287006671	Protein of unknown function (DUF968); Region: DUF968; pfam06147
99287006672	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
99287006673	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
99287006674	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
99287006675	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
99287006676	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
99287006677	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116
99287006678	Leucine-rich repeats; other site
99287006679	C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496
99287006680	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
99287006681	DinI-like family; Region: DinI; cl11630
99287006682	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
99287006683	transcriptional regulator NarP; Provisional; Region: PRK10403
99287006684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287006685	active site
99287006686	phosphorylation site [posttranslational modification]
99287006687	intermolecular recognition site; other site
99287006688	dimerization interface [polypeptide binding]; other site
99287006689	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287006690	DNA binding residues [nucleotide binding]
99287006691	dimerization interface [polypeptide binding]; other site
99287006692	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
99287006693	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
99287006694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287006695	binding surface
99287006696	TPR motif; other site
99287006697	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
99287006698	catalytic residues [active]
99287006699	central insert; other site
99287006700	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
99287006701	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
99287006702	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
99287006703	heme exporter protein CcmC; Region: ccmC; TIGR01191
99287006704	heme exporter protein CcmB; Region: ccmB; TIGR01190
99287006705	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
99287006706	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
99287006707	Walker A/P-loop; other site
99287006708	ATP binding site [chemical binding]; other site
99287006709	Q-loop/lid; other site
99287006710	ABC transporter signature motif; other site
99287006711	Walker B; other site
99287006712	D-loop; other site
99287006713	H-loop/switch region; other site
99287006714	cytochrome c-type protein NapC; Provisional; Region: PRK10617
99287006715	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
99287006716	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
99287006717	UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337
99287006718	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
99287006719	4Fe-4S binding domain; Region: Fer4_5; pfam12801
99287006720	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287006721	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
99287006722	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287006723	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287006724	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287006725	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
99287006726	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
99287006727	[4Fe-4S] binding site [ion binding]; other site
99287006728	molybdopterin cofactor binding site; other site
99287006729	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
99287006730	molybdopterin cofactor binding site; other site
99287006731	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
99287006732	ferredoxin-type protein; Provisional; Region: PRK10194
99287006733	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287006734	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
99287006735	secondary substrate binding site; other site
99287006736	primary substrate binding site; other site
99287006737	inhibition loop; other site
99287006738	dimerization interface [polypeptide binding]; other site
99287006739	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
99287006740	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
99287006741	Walker A/P-loop; other site
99287006742	ATP binding site [chemical binding]; other site
99287006743	Q-loop/lid; other site
99287006744	ABC transporter signature motif; other site
99287006745	Walker B; other site
99287006746	D-loop; other site
99287006747	H-loop/switch region; other site
99287006748	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
99287006749	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
99287006750	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
99287006751	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287006752	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
99287006753	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
99287006754	DNA binding site [nucleotide binding]
99287006755	active site
99287006756	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
99287006757	outer membrane porin protein C; Provisional; Region: PRK10554
99287006758	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
99287006759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287006760	ATP binding site [chemical binding]; other site
99287006761	G-X-G motif; other site
99287006762	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
99287006763	putative binding surface; other site
99287006764	active site
99287006765	transcriptional regulator RcsB; Provisional; Region: PRK10840
99287006766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287006767	active site
99287006768	phosphorylation site [posttranslational modification]
99287006769	intermolecular recognition site; other site
99287006770	dimerization interface [polypeptide binding]; other site
99287006771	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287006772	DNA binding residues [nucleotide binding]
99287006773	dimerization interface [polypeptide binding]; other site
99287006774	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
99287006775	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287006776	dimer interface [polypeptide binding]; other site
99287006777	phosphorylation site [posttranslational modification]
99287006778	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287006779	ATP binding site [chemical binding]; other site
99287006780	Mg2+ binding site [ion binding]; other site
99287006781	G-X-G motif; other site
99287006782	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
99287006783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287006784	active site
99287006785	phosphorylation site [posttranslational modification]
99287006786	intermolecular recognition site; other site
99287006787	dimerization interface [polypeptide binding]; other site
99287006788	DNA gyrase subunit A; Validated; Region: PRK05560
99287006789	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
99287006790	CAP-like domain; other site
99287006791	active site
99287006792	primary dimer interface [polypeptide binding]; other site
99287006793	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99287006794	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99287006795	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99287006796	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99287006797	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99287006798	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99287006799	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
99287006800	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
99287006801	active site pocket [active]
99287006802	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
99287006803	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287006804	putative substrate translocation pore; other site
99287006805	Transcriptional regulators [Transcription]; Region: GntR; COG1802
99287006806	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287006807	DNA-binding site [nucleotide binding]; DNA binding site
99287006808	FCD domain; Region: FCD; pfam07729
99287006809	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
99287006810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287006811	S-adenosylmethionine binding site [chemical binding]; other site
99287006812	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
99287006813	ATP cone domain; Region: ATP-cone; pfam03477
99287006814	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
99287006815	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
99287006816	dimer interface [polypeptide binding]; other site
99287006817	putative radical transfer pathway; other site
99287006818	diiron center [ion binding]; other site
99287006819	tyrosyl radical; other site
99287006820	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99287006821	catalytic loop [active]
99287006822	iron binding site [ion binding]; other site
99287006823	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
99287006824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287006825	putative substrate translocation pore; other site
99287006826	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
99287006827	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287006828	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
99287006829	dimerization interface [polypeptide binding]; other site
99287006830	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
99287006831	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
99287006832	active site
99287006833	catalytic site [active]
99287006834	metal binding site [ion binding]; metal-binding site
99287006835	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
99287006836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287006837	putative substrate translocation pore; other site
99287006838	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
99287006839	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287006840	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
99287006841	FAD binding domain; Region: FAD_binding_2; pfam00890
99287006842	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
99287006843	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
99287006844	Cysteine-rich domain; Region: CCG; pfam02754
99287006845	Cysteine-rich domain; Region: CCG; pfam02754
99287006846	deubiquitinase SseL; Provisional; Region: PRK14848
99287006847	hypothetical protein; Provisional; Region: PRK03673
99287006848	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
99287006849	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
99287006850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287006851	putative substrate translocation pore; other site
99287006852	L-rhamnonate dehydratase; Provisional; Region: PRK15440
99287006853	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
99287006854	putative active site pocket [active]
99287006855	putative metal binding site [ion binding]; other site
99287006856	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
99287006857	Transcriptional regulator [Transcription]; Region: IclR; COG1414
99287006858	Bacterial transcriptional regulator; Region: IclR; pfam01614
99287006859	hypothetical protein; Provisional; Region: PRK03673
99287006860	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
99287006861	putative MPT binding site; other site
99287006862	Competence-damaged protein; Region: CinA; cl00666
99287006863	YfaZ precursor; Region: YfaZ; pfam07437
99287006864	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
99287006865	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
99287006866	catalytic core [active]
99287006867	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
99287006868	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
99287006869	inhibitor-cofactor binding pocket; inhibition site
99287006870	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287006871	catalytic residue [active]
99287006872	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
99287006873	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
99287006874	Ligand binding site; other site
99287006875	Putative Catalytic site; other site
99287006876	DXD motif; other site
99287006877	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
99287006878	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
99287006879	active site
99287006880	substrate binding site [chemical binding]; other site
99287006881	cosubstrate binding site; other site
99287006882	catalytic site [active]
99287006883	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
99287006884	active site
99287006885	hexamer interface [polypeptide binding]; other site
99287006886	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
99287006887	NAD binding site [chemical binding]; other site
99287006888	substrate binding site [chemical binding]; other site
99287006889	active site
99287006890	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
99287006891	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
99287006892	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
99287006893	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
99287006894	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
99287006895	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
99287006896	Polymyxin resistance protein PmrD; Region: PmrD; pfam11183
99287006897	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
99287006898	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
99287006899	acyl-activating enzyme (AAE) consensus motif; other site
99287006900	putative AMP binding site [chemical binding]; other site
99287006901	putative active site [active]
99287006902	putative CoA binding site [chemical binding]; other site
99287006903	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
99287006904	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
99287006905	active site
99287006906	dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396
99287006907	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
99287006908	substrate binding site [chemical binding]; other site
99287006909	oxyanion hole (OAH) forming residues; other site
99287006910	trimer interface [polypeptide binding]; other site
99287006911	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
99287006912	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
99287006913	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
99287006914	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
99287006915	dimer interface [polypeptide binding]; other site
99287006916	tetramer interface [polypeptide binding]; other site
99287006917	PYR/PP interface [polypeptide binding]; other site
99287006918	TPP binding site [chemical binding]; other site
99287006919	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
99287006920	TPP-binding site; other site
99287006921	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
99287006922	isochorismate synthases; Region: isochor_syn; TIGR00543
99287006923	hypothetical protein; Provisional; Region: PRK10404
99287006924	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287006925	Coenzyme A binding pocket [chemical binding]; other site
99287006926	ribonuclease BN; Region: true_RNase_BN; TIGR02649
99287006927	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
99287006928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287006929	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99287006930	active site
99287006931	phosphorylation site [posttranslational modification]
99287006932	intermolecular recognition site; other site
99287006933	dimerization interface [polypeptide binding]; other site
99287006934	von Willebrand factor; Region: vWF_A; pfam12450
99287006935	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
99287006936	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
99287006937	metal ion-dependent adhesion site (MIDAS); other site
99287006938	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
99287006939	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
99287006940	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99287006941	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
99287006942	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99287006943	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99287006944	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
99287006945	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
99287006946	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99287006947	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
99287006948	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
99287006949	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
99287006950	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287006951	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
99287006952	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
99287006953	NADH dehydrogenase subunit G; Validated; Region: PRK08166
99287006954	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99287006955	catalytic loop [active]
99287006956	iron binding site [ion binding]; other site
99287006957	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
99287006958	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
99287006959	[4Fe-4S] binding site [ion binding]; other site
99287006960	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
99287006961	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
99287006962	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
99287006963	SLBB domain; Region: SLBB; pfam10531
99287006964	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
99287006965	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
99287006966	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
99287006967	putative dimer interface [polypeptide binding]; other site
99287006968	[2Fe-2S] cluster binding site [ion binding]; other site
99287006969	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
99287006970	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
99287006971	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174
99287006972	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
99287006973	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
99287006974	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
99287006975	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287006976	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
99287006977	putative dimerization interface [polypeptide binding]; other site
99287006978	aminotransferase AlaT; Validated; Region: PRK09265
99287006979	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99287006980	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287006981	homodimer interface [polypeptide binding]; other site
99287006982	catalytic residue [active]
99287006983	5'-nucleotidase; Provisional; Region: PRK03826
99287006984	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
99287006985	transmembrane helices; other site
99287006986	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
99287006987	TrkA-C domain; Region: TrkA_C; pfam02080
99287006988	TrkA-C domain; Region: TrkA_C; pfam02080
99287006989	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
99287006990	putative phosphatase; Provisional; Region: PRK11587
99287006991	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287006992	active site
99287006993	motif I; other site
99287006994	motif II; other site
99287006995	hypothetical protein; Validated; Region: PRK05445
99287006996	hypothetical protein; Provisional; Region: PRK01816
99287006997	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
99287006998	phosphate acetyltransferase; Reviewed; Region: PRK05632
99287006999	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99287007000	DRTGG domain; Region: DRTGG; pfam07085
99287007001	phosphate acetyltransferase; Region: pta; TIGR00651
99287007002	hypothetical protein; Provisional; Region: PRK11588
99287007003	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
99287007004	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
99287007005	PYR/PP interface [polypeptide binding]; other site
99287007006	dimer interface [polypeptide binding]; other site
99287007007	TPP binding site [chemical binding]; other site
99287007008	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
99287007009	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
99287007010	TPP-binding site [chemical binding]; other site
99287007011	dimer interface [polypeptide binding]; other site
99287007012	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996
99287007013	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
99287007014	active site
99287007015	P-loop; other site
99287007016	phosphorylation site [posttranslational modification]
99287007017	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
99287007018	active site
99287007019	phosphorylation site [posttranslational modification]
99287007020	Transcriptional regulators [Transcription]; Region: PurR; COG1609
99287007021	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287007022	DNA binding site [nucleotide binding]
99287007023	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
99287007024	putative dimerization interface [polypeptide binding]; other site
99287007025	putative ligand binding site [chemical binding]; other site
99287007026	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
99287007027	nudix motif; other site
99287007028	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
99287007029	active site
99287007030	metal binding site [ion binding]; metal-binding site
99287007031	homotetramer interface [polypeptide binding]; other site
99287007032	glutathione S-transferase; Provisional; Region: PRK15113
99287007033	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
99287007034	C-terminal domain interface [polypeptide binding]; other site
99287007035	GSH binding site (G-site) [chemical binding]; other site
99287007036	dimer interface [polypeptide binding]; other site
99287007037	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
99287007038	N-terminal domain interface [polypeptide binding]; other site
99287007039	putative dimer interface [polypeptide binding]; other site
99287007040	putative substrate binding pocket (H-site) [chemical binding]; other site
99287007041	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
99287007042	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
99287007043	C-terminal domain interface [polypeptide binding]; other site
99287007044	GSH binding site (G-site) [chemical binding]; other site
99287007045	dimer interface [polypeptide binding]; other site
99287007046	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
99287007047	N-terminal domain interface [polypeptide binding]; other site
99287007048	putative dimer interface [polypeptide binding]; other site
99287007049	active site
99287007050	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
99287007051	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
99287007052	putative NAD(P) binding site [chemical binding]; other site
99287007053	putative active site [active]
99287007054	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
99287007055	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
99287007056	Walker A/P-loop; other site
99287007057	ATP binding site [chemical binding]; other site
99287007058	Q-loop/lid; other site
99287007059	ABC transporter signature motif; other site
99287007060	Walker B; other site
99287007061	D-loop; other site
99287007062	H-loop/switch region; other site
99287007063	ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160
99287007064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287007065	dimer interface [polypeptide binding]; other site
99287007066	conserved gate region; other site
99287007067	putative PBP binding loops; other site
99287007068	ABC-ATPase subunit interface; other site
99287007069	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
99287007070	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287007071	dimer interface [polypeptide binding]; other site
99287007072	conserved gate region; other site
99287007073	putative PBP binding loops; other site
99287007074	ABC-ATPase subunit interface; other site
99287007075	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
99287007076	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287007077	substrate binding pocket [chemical binding]; other site
99287007078	membrane-bound complex binding site; other site
99287007079	hinge residues; other site
99287007080	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
99287007081	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287007082	substrate binding pocket [chemical binding]; other site
99287007083	membrane-bound complex binding site; other site
99287007084	hinge residues; other site
99287007085	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
99287007086	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
99287007087	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
99287007088	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
99287007089	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
99287007090	dimer interface [polypeptide binding]; other site
99287007091	active site
99287007092	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
99287007093	substrate binding site [chemical binding]; other site
99287007094	catalytic residue [active]
99287007095	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
99287007096	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
99287007097	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
99287007098	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
99287007099	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
99287007100	catalytic residue [active]
99287007101	PAS fold; Region: PAS_4; pfam08448
99287007102	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99287007103	putative active site [active]
99287007104	heme pocket [chemical binding]; other site
99287007105	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
99287007106	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287007107	Walker A motif; other site
99287007108	ATP binding site [chemical binding]; other site
99287007109	Walker B motif; other site
99287007110	arginine finger; other site
99287007111	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
99287007112	amidophosphoribosyltransferase; Provisional; Region: PRK09246
99287007113	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
99287007114	active site
99287007115	tetramer interface [polypeptide binding]; other site
99287007116	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99287007117	active site
99287007118	colicin V production protein; Provisional; Region: PRK10845
99287007119	cell division protein DedD; Provisional; Region: PRK11633
99287007120	Sporulation related domain; Region: SPOR; pfam05036
99287007121	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
99287007122	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99287007123	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
99287007124	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
99287007125	hypothetical protein; Provisional; Region: PRK10847
99287007126	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
99287007127	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
99287007128	dimerization interface 3.5A [polypeptide binding]; other site
99287007129	active site
99287007130	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
99287007131	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
99287007132	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
99287007133	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
99287007134	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
99287007135	ligand binding site [chemical binding]; other site
99287007136	NAD binding site [chemical binding]; other site
99287007137	catalytic site [active]
99287007138	homodimer interface [polypeptide binding]; other site
99287007139	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
99287007140	putative transporter; Provisional; Region: PRK12382
99287007141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287007142	putative substrate translocation pore; other site
99287007143	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287007144	non-specific DNA binding site [nucleotide binding]; other site
99287007145	salt bridge; other site
99287007146	sequence-specific DNA binding site [nucleotide binding]; other site
99287007147	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
99287007148	CAAX protease self-immunity; Region: Abi; pfam02517
99287007149	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
99287007150	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
99287007151	dimer interface [polypeptide binding]; other site
99287007152	active site
99287007153	Uncharacterized conserved protein [Function unknown]; Region: COG4121
99287007154	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
99287007155	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
99287007156	YfcL protein; Region: YfcL; pfam08891
99287007157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
99287007158	hypothetical protein; Provisional; Region: PRK10621
99287007159	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
99287007160	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
99287007161	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
99287007162	Tetramer interface [polypeptide binding]; other site
99287007163	active site
99287007164	FMN-binding site [chemical binding]; other site
99287007165	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805
99287007166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287007167	S-adenosylmethionine binding site [chemical binding]; other site
99287007168	hypothetical protein; Provisional; Region: PRK04946
99287007169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
99287007170	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
99287007171	catalytic core [active]
99287007172	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
99287007173	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
99287007174	substrate binding site [chemical binding]; other site
99287007175	oxyanion hole (OAH) forming residues; other site
99287007176	trimer interface [polypeptide binding]; other site
99287007177	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
99287007178	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
99287007179	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
99287007180	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
99287007181	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
99287007182	dimer interface [polypeptide binding]; other site
99287007183	active site
99287007184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
99287007185	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
99287007186	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
99287007187	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
99287007188	Outer membrane protease [Cell envelope biogenesis, outer membrane]; Region: OmpT; COG4571
99287007189	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
99287007190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287007191	active site
99287007192	phosphorylation site [posttranslational modification]
99287007193	intermolecular recognition site; other site
99287007194	dimerization interface [polypeptide binding]; other site
99287007195	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
99287007196	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
99287007197	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
99287007198	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287007199	dimerization interface [polypeptide binding]; other site
99287007200	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287007201	dimer interface [polypeptide binding]; other site
99287007202	phosphorylation site [posttranslational modification]
99287007203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287007204	ATP binding site [chemical binding]; other site
99287007205	Mg2+ binding site [ion binding]; other site
99287007206	G-X-G motif; other site
99287007207	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
99287007208	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
99287007209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287007210	putative substrate translocation pore; other site
99287007211	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
99287007212	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
99287007213	putative acyl-acceptor binding pocket; other site
99287007214	aminotransferase; Validated; Region: PRK08175
99287007215	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99287007216	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287007217	homodimer interface [polypeptide binding]; other site
99287007218	catalytic residue [active]
99287007219	glucokinase; Provisional; Region: glk; PRK00292
99287007220	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
99287007221	Cl- selectivity filter; other site
99287007222	Cl- binding residues [ion binding]; other site
99287007223	pore gating glutamate residue; other site
99287007224	dimer interface [polypeptide binding]; other site
99287007225	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
99287007226	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
99287007227	dimer interface [polypeptide binding]; other site
99287007228	PYR/PP interface [polypeptide binding]; other site
99287007229	TPP binding site [chemical binding]; other site
99287007230	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
99287007231	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
99287007232	TPP-binding site [chemical binding]; other site
99287007233	dimer interface [polypeptide binding]; other site
99287007234	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
99287007235	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99287007236	active site
99287007237	catalytic tetrad [active]
99287007238	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
99287007239	manganese transport protein MntH; Reviewed; Region: PRK00701
99287007240	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
99287007241	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
99287007242	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
99287007243	Nucleoside recognition; Region: Gate; pfam07670
99287007244	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
99287007245	MASE1; Region: MASE1; pfam05231
99287007246	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
99287007247	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287007248	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
99287007249	Winged helix-turn helix; Region: HTH_29; pfam13551
99287007250	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287007251	salt bridge; other site
99287007252	non-specific DNA binding site [nucleotide binding]; other site
99287007253	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
99287007254	sequence-specific DNA binding site [nucleotide binding]; other site
99287007255	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
99287007256	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
99287007257	active site
99287007258	HIGH motif; other site
99287007259	KMSKS motif; other site
99287007260	Protein of unknown function (DUF3150); Region: DUF3150; pfam11348
99287007261	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
99287007262	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287007263	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
99287007264	putative dimerization interface [polypeptide binding]; other site
99287007265	putative substrate binding pocket [chemical binding]; other site
99287007266	XapX domain; Region: XapX; TIGR03510
99287007267	nucleoside transporter; Region: 2A0110; TIGR00889
99287007268	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
99287007269	purine nucleoside phosphorylase; Provisional; Region: PRK08202
99287007270	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
99287007271	hypothetical protein; Provisional; Region: PRK11528
99287007272	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287007273	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287007274	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
99287007275	putative dimerization interface [polypeptide binding]; other site
99287007276	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
99287007277	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
99287007278	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
99287007279	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
99287007280	nucleotide binding pocket [chemical binding]; other site
99287007281	K-X-D-G motif; other site
99287007282	catalytic site [active]
99287007283	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
99287007284	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
99287007285	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
99287007286	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
99287007287	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
99287007288	Dimer interface [polypeptide binding]; other site
99287007289	BRCT sequence motif; other site
99287007290	cell division protein ZipA; Provisional; Region: PRK03427
99287007291	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
99287007292	FtsZ protein binding site [polypeptide binding]; other site
99287007293	putative sulfate transport protein CysZ; Validated; Region: PRK04949
99287007294	cysteine synthase; Region: PLN02565
99287007295	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
99287007296	dimer interface [polypeptide binding]; other site
99287007297	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287007298	catalytic residue [active]
99287007299	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
99287007300	dimerization domain swap beta strand [polypeptide binding]; other site
99287007301	regulatory protein interface [polypeptide binding]; other site
99287007302	active site
99287007303	regulatory phosphorylation site [posttranslational modification]; other site
99287007304	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
99287007305	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
99287007306	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
99287007307	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
99287007308	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
99287007309	HPr interaction site; other site
99287007310	glycerol kinase (GK) interaction site [polypeptide binding]; other site
99287007311	active site
99287007312	phosphorylation site [posttranslational modification]
99287007313	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
99287007314	dimer interface [polypeptide binding]; other site
99287007315	pyridoxal binding site [chemical binding]; other site
99287007316	ATP binding site [chemical binding]; other site
99287007317	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
99287007318	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287007319	DNA-binding site [nucleotide binding]; DNA binding site
99287007320	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99287007321	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287007322	homodimer interface [polypeptide binding]; other site
99287007323	catalytic residue [active]
99287007324	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
99287007325	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
99287007326	catalytic triad [active]
99287007327	hypothetical protein; Provisional; Region: PRK10318
99287007328	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
99287007329	Transglycosylase; Region: Transgly; cl19357
99287007330	cysteine synthase; Region: PLN02565
99287007331	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
99287007332	dimer interface [polypeptide binding]; other site
99287007333	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287007334	catalytic residue [active]
99287007335	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
99287007336	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287007337	Walker A/P-loop; other site
99287007338	ATP binding site [chemical binding]; other site
99287007339	Q-loop/lid; other site
99287007340	ABC transporter signature motif; other site
99287007341	Walker B; other site
99287007342	D-loop; other site
99287007343	H-loop/switch region; other site
99287007344	TOBE-like domain; Region: TOBE_3; pfam12857
99287007345	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
99287007346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287007347	dimer interface [polypeptide binding]; other site
99287007348	conserved gate region; other site
99287007349	putative PBP binding loops; other site
99287007350	ABC-ATPase subunit interface; other site
99287007351	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
99287007352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287007353	dimer interface [polypeptide binding]; other site
99287007354	conserved gate region; other site
99287007355	putative PBP binding loops; other site
99287007356	ABC-ATPase subunit interface; other site
99287007357	thiosulfate transporter subunit; Provisional; Region: PRK10852
99287007358	short chain dehydrogenase; Provisional; Region: PRK08226
99287007359	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
99287007360	NAD binding site [chemical binding]; other site
99287007361	homotetramer interface [polypeptide binding]; other site
99287007362	homodimer interface [polypeptide binding]; other site
99287007363	active site
99287007364	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
99287007365	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
99287007366	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
99287007367	putative acetyltransferase; Provisional; Region: PRK03624
99287007368	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287007369	Coenzyme A binding pocket [chemical binding]; other site
99287007370	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
99287007371	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
99287007372	active site
99287007373	metal binding site [ion binding]; metal-binding site
99287007374	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
99287007375	transcriptional regulator EutR; Provisional; Region: PRK10130
99287007376	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287007377	carboxysome structural protein EutK; Provisional; Region: PRK15466
99287007378	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
99287007379	Hexamer interface [polypeptide binding]; other site
99287007380	Hexagonal pore residue; other site
99287007381	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
99287007382	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
99287007383	Hexamer interface [polypeptide binding]; other site
99287007384	Hexagonal pore residue; other site
99287007385	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
99287007386	putative hexamer interface [polypeptide binding]; other site
99287007387	putative hexagonal pore; other site
99287007388	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
99287007389	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
99287007390	Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819
99287007391	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
99287007392	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
99287007393	active site
99287007394	metal binding site [ion binding]; metal-binding site
99287007395	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
99287007396	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99287007397	nucleotide binding site [chemical binding]; other site
99287007398	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
99287007399	nucleotide binding site [chemical binding]; other site
99287007400	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
99287007401	putative catalytic cysteine [active]
99287007402	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
99287007403	Hexamer/Pentamer interface [polypeptide binding]; other site
99287007404	central pore; other site
99287007405	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
99287007406	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
99287007407	Hexamer interface [polypeptide binding]; other site
99287007408	Hexagonal pore residue; other site
99287007409	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
99287007410	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
99287007411	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
99287007412	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
99287007413	G1 box; other site
99287007414	GTP/Mg2+ binding site [chemical binding]; other site
99287007415	G2 box; other site
99287007416	Switch I region; other site
99287007417	G3 box; other site
99287007418	Switch II region; other site
99287007419	G4 box; other site
99287007420	G5 box; other site
99287007421	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
99287007422	putative hexamer interface [polypeptide binding]; other site
99287007423	putative hexagonal pore; other site
99287007424	Transposase IS200 like; Region: Y1_Tnp; pfam01797
99287007425	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
99287007426	Malic enzyme, N-terminal domain; Region: malic; pfam00390
99287007427	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
99287007428	putative NAD(P) binding site [chemical binding]; other site
99287007429	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
99287007430	transaldolase-like protein; Provisional; Region: PTZ00411
99287007431	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
99287007432	active site
99287007433	dimer interface [polypeptide binding]; other site
99287007434	catalytic residue [active]
99287007435	transketolase; Reviewed; Region: PRK12753
99287007436	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
99287007437	TPP-binding site [chemical binding]; other site
99287007438	dimer interface [polypeptide binding]; other site
99287007439	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
99287007440	PYR/PP interface [polypeptide binding]; other site
99287007441	dimer interface [polypeptide binding]; other site
99287007442	TPP binding site [chemical binding]; other site
99287007443	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
99287007444	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
99287007445	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
99287007446	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
99287007447	dimer interface [polypeptide binding]; other site
99287007448	ADP-ribose binding site [chemical binding]; other site
99287007449	active site
99287007450	nudix motif; other site
99287007451	metal binding site [ion binding]; metal-binding site
99287007452	putative periplasmic esterase; Provisional; Region: PRK03642
99287007453	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
99287007454	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287007455	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
99287007456	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287007457	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99287007458	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
99287007459	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
99287007460	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287007461	dimerization interface [polypeptide binding]; other site
99287007462	Histidine kinase; Region: HisKA_3; pfam07730
99287007463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287007464	ATP binding site [chemical binding]; other site
99287007465	Mg2+ binding site [ion binding]; other site
99287007466	G-X-G motif; other site
99287007467	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
99287007468	MMPL family; Region: MMPL; cl14618
99287007469	MMPL family; Region: MMPL; cl14618
99287007470	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
99287007471	putative catalytic residues [active]
99287007472	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
99287007473	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
99287007474	metal binding site [ion binding]; metal-binding site
99287007475	dimer interface [polypeptide binding]; other site
99287007476	hypothetical protein; Provisional; Region: PRK13664
99287007477	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
99287007478	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
99287007479	Helicase; Region: Helicase_RecD; pfam05127
99287007480	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
99287007481	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
99287007482	Predicted metalloprotease [General function prediction only]; Region: COG2321
99287007483	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
99287007484	ATP binding site [chemical binding]; other site
99287007485	active site
99287007486	substrate binding site [chemical binding]; other site
99287007487	lipoprotein; Provisional; Region: PRK11679
99287007488	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
99287007489	dimer interface [polypeptide binding]; other site
99287007490	active site
99287007491	catalytic residue [active]
99287007492	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
99287007493	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
99287007494	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
99287007495	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
99287007496	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
99287007497	catalytic triad [active]
99287007498	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
99287007499	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
99287007500	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
99287007501	Peptidase family M48; Region: Peptidase_M48; cl12018
99287007502	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
99287007503	catalytic residues [active]
99287007504	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
99287007505	DNA replication initiation factor; Provisional; Region: PRK08084
99287007506	uracil transporter; Provisional; Region: PRK10720
99287007507	uracil-xanthine permease; Region: ncs2; TIGR00801
99287007508	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99287007509	active site
99287007510	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
99287007511	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
99287007512	dimerization interface [polypeptide binding]; other site
99287007513	putative ATP binding site [chemical binding]; other site
99287007514	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
99287007515	active site
99287007516	substrate binding site [chemical binding]; other site
99287007517	cosubstrate binding site; other site
99287007518	catalytic site [active]
99287007519	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
99287007520	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
99287007521	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
99287007522	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
99287007523	putative active site [active]
99287007524	catalytic site [active]
99287007525	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
99287007526	domain interface [polypeptide binding]; other site
99287007527	active site
99287007528	catalytic site [active]
99287007529	exopolyphosphatase; Provisional; Region: PRK10854
99287007530	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99287007531	nucleotide binding site [chemical binding]; other site
99287007532	MASE1; Region: MASE1; pfam05231
99287007533	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
99287007534	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287007535	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
99287007536	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
99287007537	Integrase core domain; Region: rve; pfam00665
99287007538	GMP synthase; Reviewed; Region: guaA; PRK00074
99287007539	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
99287007540	AMP/PPi binding site [chemical binding]; other site
99287007541	candidate oxyanion hole; other site
99287007542	catalytic triad [active]
99287007543	potential glutamine specificity residues [chemical binding]; other site
99287007544	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
99287007545	ATP Binding subdomain [chemical binding]; other site
99287007546	Ligand Binding sites [chemical binding]; other site
99287007547	Dimerization subdomain; other site
99287007548	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
99287007549	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
99287007550	active site
99287007551	Domain in cystathionine beta-synthase and other proteins; Region: CBS; smart00116
99287007552	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
99287007553	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
99287007554	generic binding surface II; other site
99287007555	generic binding surface I; other site
99287007556	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
99287007557	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
99287007558	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
99287007559	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
99287007560	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
99287007561	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
99287007562	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
99287007563	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
99287007564	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
99287007565	Autotransporter beta-domain; Region: Autotransporter; smart00869
99287007566	outer membrane protein RatB; Provisional; Region: PRK15314
99287007567	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007568	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007569	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007570	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007571	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007572	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007573	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007574	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007575	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007576	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007577	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007578	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007579	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007580	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007581	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007582	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007583	outer membrane protein RatA; Provisional; Region: PRK15315
99287007584	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007585	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007586	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007587	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007588	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007589	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007590	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007591	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007592	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007593	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007594	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
99287007595	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
99287007596	intimin-like protein SinH; Provisional; Region: PRK15318
99287007597	intimin-like protein SinH; Provisional; Region: PRK15318
99287007598	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
99287007599	zinc-ribbons; Region: zinc-ribbons_6; pfam07191
99287007600	GTP-binding protein Der; Reviewed; Region: PRK00093
99287007601	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
99287007602	G1 box; other site
99287007603	GTP/Mg2+ binding site [chemical binding]; other site
99287007604	Switch I region; other site
99287007605	G2 box; other site
99287007606	Switch II region; other site
99287007607	G3 box; other site
99287007608	G4 box; other site
99287007609	G5 box; other site
99287007610	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
99287007611	G1 box; other site
99287007612	GTP/Mg2+ binding site [chemical binding]; other site
99287007613	Switch I region; other site
99287007614	G2 box; other site
99287007615	G3 box; other site
99287007616	Switch II region; other site
99287007617	G4 box; other site
99287007618	G5 box; other site
99287007619	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
99287007620	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
99287007621	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
99287007622	Trp docking motif [polypeptide binding]; other site
99287007623	active site
99287007624	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
99287007625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
99287007626	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
99287007627	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
99287007628	dimer interface [polypeptide binding]; other site
99287007629	motif 1; other site
99287007630	active site
99287007631	motif 2; other site
99287007632	motif 3; other site
99287007633	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
99287007634	anticodon binding site; other site
99287007635	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
99287007636	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
99287007637	cytoskeletal protein RodZ; Provisional; Region: PRK10856
99287007638	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287007639	non-specific DNA binding site [nucleotide binding]; other site
99287007640	salt bridge; other site
99287007641	sequence-specific DNA binding site [nucleotide binding]; other site
99287007642	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
99287007643	23S rRNA m2A2503 methyltransferase; Region: TIGR00048
99287007644	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287007645	FeS/SAM binding site; other site
99287007646	Nucleoside diphosphate kinase; Region: NDK; pfam00334
99287007647	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
99287007648	active site
99287007649	multimer interface [polypeptide binding]; other site
99287007650	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287007651	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287007652	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
99287007653	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
99287007654	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
99287007655	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287007656	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
99287007657	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
99287007658	putative [Fe4-S4] binding site [ion binding]; other site
99287007659	putative molybdopterin cofactor binding site [chemical binding]; other site
99287007660	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
99287007661	putative molybdopterin cofactor binding site; other site
99287007662	penicillin-binding protein 1C; Provisional; Region: PRK11240
99287007663	Transglycosylase; Region: Transgly; pfam00912
99287007664	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
99287007665	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
99287007666	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
99287007667	MG2 domain; Region: A2M_N; pfam01835
99287007668	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
99287007669	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
99287007670	surface patch; other site
99287007671	thioester region; other site
99287007672	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
99287007673	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
99287007674	active site residue [active]
99287007675	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
99287007676	active site residue [active]
99287007677	SseB protein N-terminal domain; Region: SseB; pfam07179
99287007678	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
99287007679	SseB protein C-terminal domain; Region: SseB_C; pfam14581
99287007680	aminopeptidase B; Provisional; Region: PRK05015
99287007681	Peptidase; Region: DUF3663; pfam12404
99287007682	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
99287007683	interface (dimer of trimers) [polypeptide binding]; other site
99287007684	Substrate-binding/catalytic site; other site
99287007685	Zn-binding sites [ion binding]; other site
99287007686	hypothetical protein; Provisional; Region: PRK10721
99287007687	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99287007688	catalytic loop [active]
99287007689	iron binding site [ion binding]; other site
99287007690	chaperone protein HscA; Provisional; Region: hscA; PRK05183
99287007691	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
99287007692	nucleotide binding site [chemical binding]; other site
99287007693	putative NEF/HSP70 interaction site [polypeptide binding]; other site
99287007694	SBD interface [polypeptide binding]; other site
99287007695	co-chaperone HscB; Provisional; Region: hscB; PRK05014
99287007696	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
99287007697	HSP70 interaction site [polypeptide binding]; other site
99287007698	HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743
99287007699	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
99287007700	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
99287007701	trimerization site [polypeptide binding]; other site
99287007702	active site
99287007703	cysteine desulfurase; Provisional; Region: PRK14012
99287007704	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99287007705	catalytic residue [active]
99287007706	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
99287007707	Rrf2 family protein; Region: rrf2_super; TIGR00738
99287007708	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
99287007709	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
99287007710	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
99287007711	active site
99287007712	dimerization interface [polypeptide binding]; other site
99287007713	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
99287007714	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
99287007715	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
99287007716	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
99287007717	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
99287007718	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
99287007719	FAD binding pocket [chemical binding]; other site
99287007720	FAD binding motif [chemical binding]; other site
99287007721	phosphate binding motif [ion binding]; other site
99287007722	beta-alpha-beta structure motif; other site
99287007723	NAD binding pocket [chemical binding]; other site
99287007724	Iron coordination center [ion binding]; other site
99287007725	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
99287007726	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
99287007727	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
99287007728	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287007729	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
99287007730	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
99287007731	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
99287007732	PRD domain; Region: PRD; pfam00874
99287007733	PRD domain; Region: PRD; pfam00874
99287007734	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287007735	LacY proton/sugar symporter; Region: LacY_symp; pfam01306
99287007736	putative substrate translocation pore; other site
99287007737	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
99287007738	dimer interface [polypeptide binding]; other site
99287007739	active site
99287007740	glycine-pyridoxal phosphate binding site [chemical binding]; other site
99287007741	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
99287007742	folate binding site [chemical binding]; other site
99287007743	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
99287007744	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
99287007745	heme-binding site [chemical binding]; other site
99287007746	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
99287007747	FAD binding pocket [chemical binding]; other site
99287007748	FAD binding motif [chemical binding]; other site
99287007749	phosphate binding motif [ion binding]; other site
99287007750	beta-alpha-beta structure motif; other site
99287007751	NAD binding pocket [chemical binding]; other site
99287007752	Heme binding  pocket [chemical binding]; other site
99287007753	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
99287007754	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287007755	DNA binding site [nucleotide binding]
99287007756	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
99287007757	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
99287007758	lysine decarboxylase CadA; Provisional; Region: PRK15400
99287007759	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
99287007760	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
99287007761	homodimer interface [polypeptide binding]; other site
99287007762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287007763	catalytic residue [active]
99287007764	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
99287007765	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
99287007766	POT family; Region: PTR2; cl17359
99287007767	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287007768	putative substrate translocation pore; other site
99287007769	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
99287007770	response regulator GlrR; Provisional; Region: PRK15115
99287007771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287007772	active site
99287007773	phosphorylation site [posttranslational modification]
99287007774	intermolecular recognition site; other site
99287007775	dimerization interface [polypeptide binding]; other site
99287007776	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287007777	Walker A motif; other site
99287007778	ATP binding site [chemical binding]; other site
99287007779	Walker B motif; other site
99287007780	arginine finger; other site
99287007781	hypothetical protein; Provisional; Region: PRK10722
99287007782	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99287007783	HAMP domain; Region: HAMP; pfam00672
99287007784	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287007785	dimer interface [polypeptide binding]; other site
99287007786	phosphorylation site [posttranslational modification]
99287007787	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287007788	ATP binding site [chemical binding]; other site
99287007789	Mg2+ binding site [ion binding]; other site
99287007790	G-X-G motif; other site
99287007791	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
99287007792	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
99287007793	dimerization interface [polypeptide binding]; other site
99287007794	ATP binding site [chemical binding]; other site
99287007795	Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193
99287007796	dimerization interface [polypeptide binding]; other site
99287007797	ATP binding site [chemical binding]; other site
99287007798	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
99287007799	putative active site [active]
99287007800	catalytic triad [active]
99287007801	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
99287007802	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287007803	substrate binding pocket [chemical binding]; other site
99287007804	membrane-bound complex binding site; other site
99287007805	hinge residues; other site
99287007806	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
99287007807	N-acetyl-D-glucosamine binding site [chemical binding]; other site
99287007808	catalytic residue [active]
99287007809	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
99287007810	nucleoside/Zn binding site; other site
99287007811	dimer interface [polypeptide binding]; other site
99287007812	catalytic motif [active]
99287007813	hypothetical protein; Provisional; Region: PRK11590
99287007814	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
99287007815	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
99287007816	active site turn [active]
99287007817	phosphorylation site [posttranslational modification]
99287007818	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
99287007819	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
99287007820	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
99287007821	putative active site [active]
99287007822	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
99287007823	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
99287007824	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
99287007825	putative active site [active]
99287007826	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
99287007827	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
99287007828	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
99287007829	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
99287007830	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287007831	putative substrate translocation pore; other site
99287007832	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287007833	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287007834	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
99287007835	dimerization interface [polypeptide binding]; other site
99287007836	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
99287007837	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
99287007838	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
99287007839	active site
99287007840	hydrophilic channel; other site
99287007841	dimerization interface [polypeptide binding]; other site
99287007842	catalytic residues [active]
99287007843	active site lid [active]
99287007844	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
99287007845	Recombination protein O N terminal; Region: RecO_N; pfam11967
99287007846	Recombination protein O C terminal; Region: RecO_C; pfam02565
99287007847	GTPase Era; Reviewed; Region: era; PRK00089
99287007848	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
99287007849	G1 box; other site
99287007850	GTP/Mg2+ binding site [chemical binding]; other site
99287007851	Switch I region; other site
99287007852	G2 box; other site
99287007853	Switch II region; other site
99287007854	G3 box; other site
99287007855	G4 box; other site
99287007856	G5 box; other site
99287007857	KH domain; Region: KH_2; pfam07650
99287007858	ribonuclease III; Reviewed; Region: rnc; PRK00102
99287007859	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
99287007860	dimerization interface [polypeptide binding]; other site
99287007861	active site
99287007862	metal binding site [ion binding]; metal-binding site
99287007863	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
99287007864	dsRNA binding site [nucleotide binding]; other site
99287007865	signal peptidase I; Provisional; Region: PRK10861
99287007866	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
99287007867	Catalytic site [active]
99287007868	GTP-binding protein LepA; Provisional; Region: PRK05433
99287007869	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
99287007870	G1 box; other site
99287007871	putative GEF interaction site [polypeptide binding]; other site
99287007872	GTP/Mg2+ binding site [chemical binding]; other site
99287007873	Switch I region; other site
99287007874	G2 box; other site
99287007875	G3 box; other site
99287007876	Switch II region; other site
99287007877	G4 box; other site
99287007878	G5 box; other site
99287007879	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
99287007880	Elongation Factor G, domain II; Region: EFG_II; pfam14492
99287007881	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
99287007882	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
99287007883	type III secretion protein GogB; Provisional; Region: PRK15386
99287007884	Phage-encoded virulence factor; Region: PAGK; pfam15284
99287007885	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
99287007886	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
99287007887	ADP-ribose binding site [chemical binding]; other site
99287007888	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
99287007889	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
99287007890	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
99287007891	Phage Tail Collar Domain; Region: Collar; pfam07484
99287007892	Phage-related protein, tail component [Function unknown]; Region: COG4733
99287007893	Putative phage tail protein; Region: Phage-tail_3; pfam13550
99287007894	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
99287007895	Interdomain contacts; other site
99287007896	Cytokine receptor motif; other site
99287007897	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
99287007898	Fibronectin type III protein; Region: DUF3672; pfam12421
99287007899	Phage-related protein, tail component [Function unknown]; Region: COG4723
99287007900	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
99287007901	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
99287007902	NlpC/P60 family; Region: NLPC_P60; cl17555
99287007903	Phage-related protein [Function unknown]; Region: gp18; COG4672
99287007904	Phage-related protein [Function unknown]; Region: COG4718
99287007905	Phage-related minor tail protein [Function unknown]; Region: COG5281
99287007906	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
99287007907	phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541
99287007908	Minor tail protein T; Region: Phage_tail_T; pfam06223
99287007909	Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894
99287007910	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
99287007911	Phage tail protein; Region: Phage_tail_3; pfam08813
99287007912	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
99287007913	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
99287007914	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
99287007915	Probable transposase; Region: OrfB_IS605; pfam01385
99287007916	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
99287007917	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
99287007918	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094
99287007919	DNA packaging protein FI; Region: Packaging_FI; pfam14000
99287007920	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
99287007921	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
99287007922	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
99287007923	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
99287007924	tandem repeat interface [polypeptide binding]; other site
99287007925	oligomer interface [polypeptide binding]; other site
99287007926	active site residues [active]
99287007927	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
99287007928	gpW; Region: gpW; pfam02831
99287007929	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
99287007930	Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471
99287007931	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
99287007932	Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245
99287007933	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
99287007934	catalytic residues [active]
99287007935	phage holin, lambda family; Region: holin_lambda; TIGR01594
99287007936	PipA protein; Region: PipA; pfam07108
99287007937	ORF6N domain; Region: ORF6N; pfam10543
99287007938	Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323
99287007939	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
99287007940	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
99287007941	DinI-like family; Region: DinI; pfam06183
99287007942	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
99287007943	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
99287007944	putative replication protein; Provisional; Region: PRK12377
99287007945	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287007946	Walker A motif; other site
99287007947	ATP binding site [chemical binding]; other site
99287007948	Walker B motif; other site
99287007949	arginine finger; other site
99287007950	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
99287007951	primosomal protein DnaI; Provisional; Region: PRK02854
99287007952	Bacteriophage CII protein; Region: Phage_CII; pfam05269
99287007953	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287007954	non-specific DNA binding site [nucleotide binding]; other site
99287007955	salt bridge; other site
99287007956	sequence-specific DNA binding site [nucleotide binding]; other site
99287007957	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
99287007958	exonuclease VIII; Reviewed; Region: PRK09709
99287007959	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
99287007960	RecT family; Region: RecT; pfam03837
99287007961	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
99287007962	integrase; Provisional; Region: PRK09692
99287007963	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
99287007964	active site
99287007965	Int/Topo IB signature motif; other site
99287007966	SoxR reducing system protein RseC; Provisional; Region: PRK10862
99287007967	anti-sigma E factor; Provisional; Region: rseB; PRK09455
99287007968	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
99287007969	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
99287007970	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
99287007971	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
99287007972	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99287007973	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99287007974	DNA binding residues [nucleotide binding]
99287007975	L-aspartate oxidase; Provisional; Region: PRK09077
99287007976	L-aspartate oxidase; Provisional; Region: PRK06175
99287007977	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
99287007978	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
99287007979	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287007980	S-adenosylmethionine binding site [chemical binding]; other site
99287007981	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
99287007982	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
99287007983	ATP binding site [chemical binding]; other site
99287007984	Mg++ binding site [ion binding]; other site
99287007985	motif III; other site
99287007986	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287007987	nucleotide binding region [chemical binding]; other site
99287007988	ATP-binding site [chemical binding]; other site
99287007989	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287007990	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287007991	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
99287007992	dimerization interface [polypeptide binding]; other site
99287007993	cysteine/O-acetylserine exporter; Provisional; Region: PRK10323
99287007994	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
99287007995	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
99287007996	ligand binding site [chemical binding]; other site
99287007997	active site
99287007998	UGI interface [polypeptide binding]; other site
99287007999	catalytic site [active]
99287008000	putative methyltransferase; Provisional; Region: PRK10864
99287008001	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
99287008002	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
99287008003	thioredoxin 2; Provisional; Region: PRK10996
99287008004	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
99287008005	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
99287008006	catalytic residues [active]
99287008007	Uncharacterized conserved protein [Function unknown]; Region: COG3148
99287008008	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
99287008009	CoA binding domain; Region: CoA_binding_2; pfam13380
99287008010	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
99287008011	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
99287008012	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
99287008013	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287008014	Coenzyme A binding pocket [chemical binding]; other site
99287008015	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
99287008016	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
99287008017	domain interface [polypeptide binding]; other site
99287008018	putative active site [active]
99287008019	catalytic site [active]
99287008020	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
99287008021	domain interface [polypeptide binding]; other site
99287008022	putative active site [active]
99287008023	catalytic site [active]
99287008024	lipoprotein; Provisional; Region: PRK10759
99287008025	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
99287008026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287008027	putative substrate translocation pore; other site
99287008028	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
99287008029	protein disaggregation chaperone; Provisional; Region: PRK10865
99287008030	Clp amino terminal domain; Region: Clp_N; pfam02861
99287008031	Clp amino terminal domain; Region: Clp_N; pfam02861
99287008032	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287008033	Walker A motif; other site
99287008034	ATP binding site [chemical binding]; other site
99287008035	Walker B motif; other site
99287008036	arginine finger; other site
99287008037	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
99287008038	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287008039	Walker A motif; other site
99287008040	ATP binding site [chemical binding]; other site
99287008041	Walker B motif; other site
99287008042	arginine finger; other site
99287008043	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
99287008044	hypothetical protein; Provisional; Region: PRK10723
99287008045	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
99287008046	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99287008047	RNA binding surface [nucleotide binding]; other site
99287008048	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
99287008049	active site
99287008050	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
99287008051	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
99287008052	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
99287008053	30S subunit binding site; other site
99287008054	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
99287008055	Chorismate mutase type II; Region: CM_2; cl00693
99287008056	Prephenate dehydratase; Region: PDT; pfam00800
99287008057	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
99287008058	putative L-Phe binding site [chemical binding]; other site
99287008059	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
99287008060	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
99287008061	Chorismate mutase type II; Region: CM_2; cl00693
99287008062	prephenate dehydrogenase; Validated; Region: PRK08507
99287008063	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
99287008064	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
99287008065	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
99287008066	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99287008067	metal binding site [ion binding]; metal-binding site
99287008068	active site
99287008069	I-site; other site
99287008070	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
99287008071	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
99287008072	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
99287008073	RimM N-terminal domain; Region: RimM; pfam01782
99287008074	PRC-barrel domain; Region: PRC; pfam05239
99287008075	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
99287008076	signal recognition particle protein; Provisional; Region: PRK10867
99287008077	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
99287008078	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
99287008079	P loop; other site
99287008080	GTP binding site [chemical binding]; other site
99287008081	Signal peptide binding domain; Region: SRP_SPB; pfam02978
99287008082	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
99287008083	hypothetical protein; Provisional; Region: PRK11573
99287008084	Domain of unknown function DUF21; Region: DUF21; pfam01595
99287008085	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
99287008086	Transporter associated domain; Region: CorC_HlyC; smart01091
99287008087	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511
99287008088	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
99287008089	dimer interface [polypeptide binding]; other site
99287008090	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
99287008091	cytoplasmic protein; contains frameshifts
99287008092	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
99287008093	recombination and repair protein; Provisional; Region: PRK10869
99287008094	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
99287008095	Walker A/P-loop; other site
99287008096	ATP binding site [chemical binding]; other site
99287008097	Q-loop/lid; other site
99287008098	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
99287008099	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
99287008100	ABC transporter signature motif; other site
99287008101	Walker B; other site
99287008102	D-loop; other site
99287008103	H-loop/switch region; other site
99287008104	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
99287008105	hypothetical protein; Validated; Region: PRK01777
99287008106	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
99287008107	putative coenzyme Q binding site [chemical binding]; other site
99287008108	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
99287008109	SmpB-tmRNA interface; other site
99287008110	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
99287008111	Outer membrane efflux protein; Region: OEP; pfam02321
99287008112	Outer membrane efflux protein; Region: OEP; pfam02321
99287008113	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
99287008114	putative active site [active]
99287008115	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
99287008116	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99287008117	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287008118	Walker A/P-loop; other site
99287008119	ATP binding site [chemical binding]; other site
99287008120	Q-loop/lid; other site
99287008121	ABC transporter signature motif; other site
99287008122	Walker B; other site
99287008123	D-loop; other site
99287008124	H-loop/switch region; other site
99287008125	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
99287008126	HlyD family secretion protein; Region: HlyD_3; pfam13437
99287008127	Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592
99287008128	tail protein; Provisional; Region: D; PHA02561
99287008129	Phage protein U [General function prediction only]; Region: COG3499
99287008130	Phage-related tail protein [Function unknown]; Region: COG5283
99287008131	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
99287008132	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
99287008133	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
99287008134	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
99287008135	major tail tube protein; Provisional; Region: FII; PHA02600
99287008136	major tail sheath protein; Provisional; Region: FI; PHA02560
99287008137	multiple promoter invertase; Provisional; Region: mpi; PRK13413
99287008138	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
99287008139	catalytic residues [active]
99287008140	catalytic nucleophile [active]
99287008141	Presynaptic Site I dimer interface [polypeptide binding]; other site
99287008142	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
99287008143	Synaptic Flat tetramer interface [polypeptide binding]; other site
99287008144	Synaptic Site I dimer interface [polypeptide binding]; other site
99287008145	DNA binding site [nucleotide binding]
99287008146	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
99287008147	DNA-binding interface [nucleotide binding]; DNA binding site
99287008148	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
99287008149	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
99287008150	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
99287008151	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
99287008152	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
99287008153	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
99287008154	baseplate assembly protein; Provisional; Region: J; PHA02568
99287008155	baseplate wedge subunit; Provisional; Region: W; PHA02516
99287008156	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
99287008157	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
99287008158	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
99287008159	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
99287008160	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
99287008161	catalytic residues [active]
99287008162	Transmembrane protein 223; Region: TMEM223; pfam14640
99287008163	P2-like prophage tail protein X [General function prediction only]; Region: COG5004
99287008164	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
99287008165	terminase endonuclease subunit; Provisional; Region: M; PHA02537
99287008166	capsid protein; Provisional; Region: N; PHA02538
99287008167	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
99287008168	terminase ATPase subunit; Provisional; Region: P; PHA02535
99287008169	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
99287008170	Phage Terminase; Region: Terminase_1; cl19862
99287008171	portal vertex protein; Provisional; Region: Q; PHA02536
99287008172	AIPR protein; Region: AIPR; pfam10592
99287008173	DinI-like family; Region: DinI; pfam06183
99287008174	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
99287008175	DNA adenine methylase (dam); Region: dam; TIGR00571
99287008176	DksA-like zinc finger domain containing protein; Region: PHA00080
99287008177	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
99287008178	Protein of unknown function (DUF2724); Region: DUF2724; pfam10893
99287008179	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
99287008180	Predicted transcriptional regulator [Transcription]; Region: COG2932
99287008181	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
99287008182	integrase; Provisional; Region: int; PHA02601
99287008183	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
99287008184	active site
99287008185	DNA binding site [nucleotide binding]
99287008186	Int/Topo IB signature motif; other site
99287008187	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
99287008188	active site
99287008189	Int/Topo IB signature motif; other site
99287008190	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
99287008191	SEC-C motif; Region: SEC-C; pfam02810
99287008192	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
99287008193	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
99287008194	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
99287008195	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287008196	Walker A/P-loop; other site
99287008197	ATP binding site [chemical binding]; other site
99287008198	AAA domain; Region: AAA_21; pfam13304
99287008199	ABC transporter signature motif; other site
99287008200	Walker B; other site
99287008201	D-loop; other site
99287008202	H-loop/switch region; other site
99287008203	Protein of unknown function (DUF4435); Region: DUF4435; pfam14491
99287008204	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
99287008205	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287008206	non-specific DNA binding site [nucleotide binding]; other site
99287008207	salt bridge; other site
99287008208	sequence-specific DNA binding site [nucleotide binding]; other site
99287008209	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
99287008210	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
99287008211	Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731
99287008212	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
99287008213	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
99287008214	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
99287008215	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
99287008216	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99287008217	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
99287008218	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
99287008219	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
99287008220	active site
99287008221	dimer interface [polypeptide binding]; other site
99287008222	magnesium binding site [ion binding]; other site
99287008223	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
99287008224	tetramer interface [polypeptide binding]; other site
99287008225	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
99287008226	active site
99287008227	Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560
99287008228	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
99287008229	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
99287008230	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
99287008231	active site turn [active]
99287008232	phosphorylation site [posttranslational modification]
99287008233	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
99287008234	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
99287008235	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
99287008236	Phage integrase, N-terminal; Region: Phage_int_SAM_2; pfam12834
99287008237	Integrase; Region: Integrase_1; pfam12835
99287008238	integrase
99287008239	Transposase; Region: HTH_Tnp_1; pfam01527
99287008240	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
99287008241	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
99287008242	Transposase; Region: HTH_Tnp_1; cl17663
99287008243	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
99287008244	putative transposase OrfB; Reviewed; Region: PHA02517
99287008245	HTH-like domain; Region: HTH_21; pfam13276
99287008246	Integrase core domain; Region: rve; pfam00665
99287008247	Integrase core domain; Region: rve_3; pfam13683
99287008248	Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614
99287008249	flagellin; Validated; Region: PRK08026
99287008250	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
99287008251	Flagellin D3 domain; Region: Flagellin_D3; pfam08884
99287008252	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
99287008253	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
99287008254	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
99287008255	catalytic residues [active]
99287008256	catalytic nucleophile [active]
99287008257	Presynaptic Site I dimer interface [polypeptide binding]; other site
99287008258	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
99287008259	Synaptic Flat tetramer interface [polypeptide binding]; other site
99287008260	Synaptic Site I dimer interface [polypeptide binding]; other site
99287008261	DNA binding site [nucleotide binding]
99287008262	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
99287008263	DNA-binding interface [nucleotide binding]; DNA binding site
99287008264	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
99287008265	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
99287008266	homodimer interface [polypeptide binding]; other site
99287008267	active site
99287008268	TDP-binding site; other site
99287008269	acceptor substrate-binding pocket; other site
99287008270	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99287008271	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99287008272	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287008273	Walker A/P-loop; other site
99287008274	ATP binding site [chemical binding]; other site
99287008275	Q-loop/lid; other site
99287008276	ABC transporter signature motif; other site
99287008277	Walker B; other site
99287008278	D-loop; other site
99287008279	H-loop/switch region; other site
99287008280	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
99287008281	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99287008282	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287008283	Walker A/P-loop; other site
99287008284	ATP binding site [chemical binding]; other site
99287008285	Q-loop/lid; other site
99287008286	ABC transporter signature motif; other site
99287008287	Walker B; other site
99287008288	D-loop; other site
99287008289	H-loop/switch region; other site
99287008290	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
99287008291	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
99287008292	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
99287008293	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
99287008294	outer membrane receptor FepA; Provisional; Region: PRK13528
99287008295	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99287008296	N-terminal plug; other site
99287008297	ligand-binding site [chemical binding]; other site
99287008298	secreted effector protein PipB2; Provisional; Region: PRK15196
99287008299	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99287008300	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99287008301	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99287008302	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99287008303	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
99287008304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
99287008305	antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312
99287008306	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
99287008307	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
99287008308	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
99287008309	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287008310	dimer interface [polypeptide binding]; other site
99287008311	phosphorylation site [posttranslational modification]
99287008312	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287008313	ATP binding site [chemical binding]; other site
99287008314	Mg2+ binding site [ion binding]; other site
99287008315	G-X-G motif; other site
99287008316	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
99287008317	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287008318	active site
99287008319	phosphorylation site [posttranslational modification]
99287008320	intermolecular recognition site; other site
99287008321	dimerization interface [polypeptide binding]; other site
99287008322	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287008323	DNA binding site [nucleotide binding]
99287008324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
99287008325	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
99287008326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
99287008327	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
99287008328	substrate binding pocket [chemical binding]; other site
99287008329	active site
99287008330	iron coordination sites [ion binding]; other site
99287008331	hydroxyglutarate oxidase; Provisional; Region: PRK11728
99287008332	Predicted dehydrogenase [General function prediction only]; Region: COG0579
99287008333	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
99287008334	tetramerization interface [polypeptide binding]; other site
99287008335	NAD(P) binding site [chemical binding]; other site
99287008336	catalytic residues [active]
99287008337	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
99287008338	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
99287008339	inhibitor-cofactor binding pocket; inhibition site
99287008340	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287008341	catalytic residue [active]
99287008342	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
99287008343	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
99287008344	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
99287008345	helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345
99287008346	DNA-binding site [nucleotide binding]; DNA binding site
99287008347	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
99287008348	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
99287008349	bacterial OsmY and nodulation domain; Region: BON; smart00749
99287008350	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
99287008351	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
99287008352	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99287008353	dimerization interface [polypeptide binding]; other site
99287008354	putative DNA binding site [nucleotide binding]; other site
99287008355	putative Zn2+ binding site [ion binding]; other site
99287008356	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
99287008357	active site residue [active]
99287008358	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
99287008359	Domain in histone-like proteins of HNS family; Region: HNS; cl19571
99287008360	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
99287008361	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
99287008362	hypothetical protein; Provisional; Region: PRK10556
99287008363	hypothetical protein; Provisional; Region: PRK10132
99287008364	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
99287008365	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287008366	DNA-binding site [nucleotide binding]; DNA binding site
99287008367	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99287008368	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287008369	homodimer interface [polypeptide binding]; other site
99287008370	catalytic residue [active]
99287008371	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
99287008372	Uncharacterized conserved protein [Function unknown]; Region: COG2128
99287008373	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
99287008374	catalytic residues [active]
99287008375	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
99287008376	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
99287008377	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
99287008378	Class I ribonucleotide reductase; Region: RNR_I; cd01679
99287008379	active site
99287008380	dimer interface [polypeptide binding]; other site
99287008381	catalytic residues [active]
99287008382	effector binding site; other site
99287008383	R2 peptide binding site; other site
99287008384	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
99287008385	dimer interface [polypeptide binding]; other site
99287008386	putative radical transfer pathway; other site
99287008387	diiron center [ion binding]; other site
99287008388	tyrosyl radical; other site
99287008389	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
99287008390	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
99287008391	Walker A/P-loop; other site
99287008392	ATP binding site [chemical binding]; other site
99287008393	Q-loop/lid; other site
99287008394	ABC transporter signature motif; other site
99287008395	Walker B; other site
99287008396	D-loop; other site
99287008397	H-loop/switch region; other site
99287008398	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
99287008399	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
99287008400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287008401	dimer interface [polypeptide binding]; other site
99287008402	conserved gate region; other site
99287008403	putative PBP binding loops; other site
99287008404	ABC-ATPase subunit interface; other site
99287008405	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
99287008406	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
99287008407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287008408	putative substrate translocation pore; other site
99287008409	transcriptional repressor MprA; Provisional; Region: PRK10870
99287008410	Transcriptional regulators [Transcription]; Region: MarR; COG1846
99287008411	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
99287008412	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99287008413	HlyD family secretion protein; Region: HlyD_3; pfam13437
99287008414	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
99287008415	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287008416	putative substrate translocation pore; other site
99287008417	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
99287008418	S-ribosylhomocysteinase; Provisional; Region: PRK02260
99287008419	glutamate--cysteine ligase; Provisional; Region: PRK02107
99287008420	Predicted membrane protein [Function unknown]; Region: COG1238
99287008421	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
99287008422	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287008423	active site
99287008424	motif I; other site
99287008425	motif II; other site
99287008426	carbon storage regulator; Provisional; Region: PRK01712
99287008427	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
99287008428	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
99287008429	motif 1; other site
99287008430	active site
99287008431	motif 2; other site
99287008432	motif 3; other site
99287008433	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
99287008434	DHHA1 domain; Region: DHHA1; pfam02272
99287008435	recombination regulator RecX; Reviewed; Region: recX; PRK00117
99287008436	recombinase A; Provisional; Region: recA; PRK09354
99287008437	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
99287008438	hexamer interface [polypeptide binding]; other site
99287008439	Walker A motif; other site
99287008440	ATP binding site [chemical binding]; other site
99287008441	Walker B motif; other site
99287008442	hypothetical protein; Validated; Region: PRK03661
99287008443	murein hydrolase B; Provisional; Region: PRK10760
99287008444	lytic murein transglycosylase B; Region: MltB; TIGR02282
99287008445	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
99287008446	N-acetyl-D-glucosamine binding site [chemical binding]; other site
99287008447	PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821
99287008448	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
99287008449	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
99287008450	Nucleoside recognition; Region: Gate; pfam07670
99287008451	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
99287008452	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
99287008453	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
99287008454	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
99287008455	putative NAD(P) binding site [chemical binding]; other site
99287008456	active site
99287008457	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
99287008458	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
99287008459	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
99287008460	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287008461	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
99287008462	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
99287008463	putative active site [active]
99287008464	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
99287008465	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
99287008466	GAF domain; Region: GAF; pfam01590
99287008467	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287008468	Walker A motif; other site
99287008469	ATP binding site [chemical binding]; other site
99287008470	Walker B motif; other site
99287008471	arginine finger; other site
99287008472	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
99287008473	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
99287008474	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
99287008475	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
99287008476	iron binding site [ion binding]; other site
99287008477	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
99287008478	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287008479	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99287008480	Acylphosphatase; Region: Acylphosphatase; pfam00708
99287008481	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
99287008482	HypF finger; Region: zf-HYPF; pfam07503
99287008483	HypF finger; Region: zf-HYPF; pfam07503
99287008484	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
99287008485	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
99287008486	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287008487	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
99287008488	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
99287008489	nickel binding site [ion binding]; other site
99287008490	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
99287008491	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
99287008492	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
99287008493	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287008494	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
99287008495	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
99287008496	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
99287008497	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
99287008498	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
99287008499	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
99287008500	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
99287008501	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287008502	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287008503	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
99287008504	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
99287008505	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
99287008506	hydrogenase assembly chaperone; Provisional; Region: PRK10409
99287008507	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
99287008508	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
99287008509	dimerization interface [polypeptide binding]; other site
99287008510	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
99287008511	ATP binding site [chemical binding]; other site
99287008512	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
99287008513	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99287008514	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99287008515	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287008516	Walker A motif; other site
99287008517	ATP binding site [chemical binding]; other site
99287008518	Walker B motif; other site
99287008519	arginine finger; other site
99287008520	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
99287008521	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
99287008522	SPI-1; Salmonella pathogenicity island 1; major conserved pathogenicity island in Salmonella spp.; required invasion of epithelial cells and inducation of inflammatory response; encodes a type III secretion system that delivers effector molecules to host cells; TTSS-1
99287008523	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
99287008524	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
99287008525	metal binding site [ion binding]; metal-binding site
99287008526	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
99287008527	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
99287008528	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
99287008529	ABC-ATPase subunit  interface; other site
99287008530	dimer interface [polypeptide binding]; other site
99287008531	putative PBP binding regions; other site
99287008532	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
99287008533	ABC-ATPase subunit  interface; other site
99287008534	dimer interface [polypeptide binding]; other site
99287008535	putative PBP binding regions; other site
99287008536	effector protein YopJ; Provisional; Region: PRK15371
99287008537	transcriptional activator SprB; Provisional; Region: PRK15320
99287008538	transcriptional regulator SirC; Provisional; Region: PRK15044
99287008539	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287008540	putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321
99287008541	invasion protein OrgB; Provisional; Region: PRK15322
99287008542	invasion protein OrgA; Provisional; Region: PRK15323
99287008543	type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324
99287008544	type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325
99287008545	type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326
99287008546	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327
99287008547	transcriptional regulator HilD; Provisional; Region: PRK15185
99287008548	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287008549	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287008550	invasion protein regulator; Provisional; Region: PRK12370
99287008551	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287008552	DNA binding site [nucleotide binding]
99287008553	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287008554	binding surface
99287008555	TPR motif; other site
99287008556	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
99287008557	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
99287008558	N-acetyl-D-glucosamine binding site [chemical binding]; other site
99287008559	catalytic residue [active]
99287008560	pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375
99287008561	SicP binding; Region: SicP-binding; pfam09119
99287008562	GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219
99287008563	switch II binding region; other site
99287008564	Rac1 P-loop interaction site [polypeptide binding]; other site
99287008565	GTP binding residues [chemical binding]; other site
99287008566	switch I binding region; other site
99287008567	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047
99287008568	active site
99287008569	chaperone protein SicP; Provisional; Region: PRK15329
99287008570	putative acyl carrier protein IacP; Validated; Region: PRK08172
99287008571	pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376
99287008572	cell invasion protein SipD; Provisional; Region: PRK15330
99287008573	pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373
99287008574	pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374
99287008575	Secretion system effector C (SseC) like family; Region: SseC; pfam04888
99287008576	chaperone protein SicA; Provisional; Region: PRK15331
99287008577	Tetratricopeptide repeat; Region: TPR_3; pfam07720
99287008578	Tetratricopeptide repeat; Region: TPR_3; pfam07720
99287008579	type III secretion system protein SpaS; Validated; Region: PRK08156
99287008580	type III secretion system protein SpaR; Provisional; Region: PRK15332
99287008581	type III secretion system protein SpaQ; Provisional; Region: PRK15333
99287008582	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
99287008583	type III secretion system protein SpaO; Validated; Region: PRK08158
99287008584	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
99287008585	Surface presentation of antigens protein; Region: SPAN; cl19597
99287008586	Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090
99287008587	ATP synthase SpaL; Validated; Region: PRK08149
99287008588	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
99287008589	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
99287008590	Walker A motif; other site
99287008591	ATP binding site [chemical binding]; other site
99287008592	Walker B motif; other site
99287008593	type III secretion system chaperone SpaK; Provisional; Region: PRK15336
99287008594	type III secretion system protein InvA; Provisional; Region: PRK15337
99287008595	type III secretion system regulator InvE; Provisional; Region: PRK15338
99287008596	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
99287008597	type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339
99287008598	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
99287008599	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
99287008600	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
99287008601	transcriptional regulator InvF; Provisional; Region: PRK15340
99287008602	InvH outer membrane lipoprotein; Region: InvH; pfam04741
99287008603	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
99287008604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
99287008605	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
99287008606	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
99287008607	fragment of transposase
99287008608	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
99287008609	active site
99287008610	metal binding site [ion binding]; metal-binding site
99287008611	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
99287008612	MutS domain I; Region: MutS_I; pfam01624
99287008613	MutS domain II; Region: MutS_II; pfam05188
99287008614	MutS domain III; Region: MutS_III; pfam05192
99287008615	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
99287008616	Walker A/P-loop; other site
99287008617	ATP binding site [chemical binding]; other site
99287008618	Q-loop/lid; other site
99287008619	ABC transporter signature motif; other site
99287008620	Walker B; other site
99287008621	D-loop; other site
99287008622	H-loop/switch region; other site
99287008623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
99287008624	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287008625	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99287008626	putative substrate translocation pore; other site
99287008627	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287008628	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287008629	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
99287008630	putative effector binding pocket; other site
99287008631	dimerization interface [polypeptide binding]; other site
99287008632	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
99287008633	GntP family permease; Region: GntP_permease; pfam02447
99287008634	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
99287008635	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
99287008636	putative NAD(P) binding site [chemical binding]; other site
99287008637	active site
99287008638	putative substrate binding site [chemical binding]; other site
99287008639	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
99287008640	hypothetical protein; Provisional; Region: PRK09989
99287008641	putative aldolase; Validated; Region: PRK08130
99287008642	intersubunit interface [polypeptide binding]; other site
99287008643	active site
99287008644	Zn2+ binding site [ion binding]; other site
99287008645	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
99287008646	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
99287008647	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
99287008648	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
99287008649	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
99287008650	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
99287008651	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287008652	Transcriptional regulators [Transcription]; Region: MarR; COG1846
99287008653	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
99287008654	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
99287008655	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
99287008656	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
99287008657	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
99287008658	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
99287008659	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99287008660	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
99287008661	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99287008662	DNA binding residues [nucleotide binding]
99287008663	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
99287008664	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
99287008665	Peptidase family M23; Region: Peptidase_M23; pfam01551
99287008666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287008667	S-adenosylmethionine binding site [chemical binding]; other site
99287008668	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
99287008669	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
99287008670	Permutation of conserved domain; other site
99287008671	active site
99287008672	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
99287008673	homotrimer interaction site [polypeptide binding]; other site
99287008674	zinc binding site [ion binding]; other site
99287008675	CDP-binding sites; other site
99287008676	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
99287008677	substrate binding site; other site
99287008678	dimer interface; other site
99287008679	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
99287008680	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
99287008681	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
99287008682	ligand-binding site [chemical binding]; other site
99287008683	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
99287008684	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
99287008685	CysD dimerization site [polypeptide binding]; other site
99287008686	G1 box; other site
99287008687	putative GEF interaction site [polypeptide binding]; other site
99287008688	GTP/Mg2+ binding site [chemical binding]; other site
99287008689	Switch I region; other site
99287008690	G2 box; other site
99287008691	G3 box; other site
99287008692	Switch II region; other site
99287008693	G4 box; other site
99287008694	G5 box; other site
99287008695	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
99287008696	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
99287008697	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
99287008698	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
99287008699	Active Sites [active]
99287008700	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
99287008701	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
99287008702	metal binding site [ion binding]; metal-binding site
99287008703	putative ssRNA endonuclease; Provisional; Region: PRK11558
99287008704	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
99287008705	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
99287008706	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
99287008707	CT1975-like protein; Region: Cas_CT1975; pfam09344
99287008708	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
99287008709	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669
99287008710	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
99287008711	CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203
99287008712	CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639
99287008713	pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379
99287008714	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
99287008715	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
99287008716	Active Sites [active]
99287008717	sulfite reductase subunit beta; Provisional; Region: PRK13504
99287008718	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
99287008719	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
99287008720	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
99287008721	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287008722	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
99287008723	Flavodoxin; Region: Flavodoxin_1; pfam00258
99287008724	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
99287008725	FAD binding pocket [chemical binding]; other site
99287008726	FAD binding motif [chemical binding]; other site
99287008727	catalytic residues [active]
99287008728	NAD binding pocket [chemical binding]; other site
99287008729	phosphate binding motif [ion binding]; other site
99287008730	beta-alpha-beta structure motif; other site
99287008731	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
99287008732	active site
99287008733	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
99287008734	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
99287008735	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
99287008736	enolase; Provisional; Region: eno; PRK00077
99287008737	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
99287008738	dimer interface [polypeptide binding]; other site
99287008739	metal binding site [ion binding]; metal-binding site
99287008740	substrate binding pocket [chemical binding]; other site
99287008741	CTP synthetase; Validated; Region: pyrG; PRK05380
99287008742	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
99287008743	Catalytic site [active]
99287008744	active site
99287008745	UTP binding site [chemical binding]; other site
99287008746	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
99287008747	active site
99287008748	putative oxyanion hole; other site
99287008749	catalytic triad [active]
99287008750	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
99287008751	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
99287008752	homodimer interface [polypeptide binding]; other site
99287008753	metal binding site [ion binding]; metal-binding site
99287008754	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
99287008755	homodimer interface [polypeptide binding]; other site
99287008756	active site
99287008757	putative chemical substrate binding site [chemical binding]; other site
99287008758	metal binding site [ion binding]; metal-binding site
99287008759	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
99287008760	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
99287008761	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
99287008762	HD domain; Region: HD_4; pfam13328
99287008763	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
99287008764	synthetase active site [active]
99287008765	NTP binding site [chemical binding]; other site
99287008766	metal binding site [ion binding]; metal-binding site
99287008767	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
99287008768	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
99287008769	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
99287008770	TRAM domain; Region: TRAM; pfam01938
99287008771	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287008772	S-adenosylmethionine binding site [chemical binding]; other site
99287008773	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
99287008774	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
99287008775	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287008776	dimerization interface [polypeptide binding]; other site
99287008777	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287008778	dimer interface [polypeptide binding]; other site
99287008779	phosphorylation site [posttranslational modification]
99287008780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287008781	ATP binding site [chemical binding]; other site
99287008782	Mg2+ binding site [ion binding]; other site
99287008783	G-X-G motif; other site
99287008784	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
99287008785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287008786	active site
99287008787	phosphorylation site [posttranslational modification]
99287008788	intermolecular recognition site; other site
99287008789	dimerization interface [polypeptide binding]; other site
99287008790	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
99287008791	putative binding surface; other site
99287008792	active site
99287008793	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
99287008794	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
99287008795	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
99287008796	active site
99287008797	tetramer interface [polypeptide binding]; other site
99287008798	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
99287008799	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
99287008800	active site
99287008801	tetramer interface [polypeptide binding]; other site
99287008802	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287008803	D-galactonate transporter; Region: 2A0114; TIGR00893
99287008804	putative substrate translocation pore; other site
99287008805	flavodoxin; Provisional; Region: PRK08105
99287008806	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
99287008807	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
99287008808	probable active site [active]
99287008809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
99287008810	SecY interacting protein Syd; Provisional; Region: PRK04968
99287008811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
99287008812	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
99287008813	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
99287008814	Domain of unknown function (DUF4478); Region: DUF4478; pfam14793
99287008815	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
99287008816	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
99287008817	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
99287008818	serine transporter; Region: stp; TIGR00814
99287008819	L-serine dehydratase TdcG; Provisional; Region: PRK15040
99287008820	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
99287008821	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
99287008822	flap endonuclease-like protein; Provisional; Region: PRK09482
99287008823	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
99287008824	active site
99287008825	metal binding site 1 [ion binding]; metal-binding site
99287008826	putative 5' ssDNA interaction site; other site
99287008827	metal binding site 3; metal-binding site
99287008828	metal binding site 2 [ion binding]; metal-binding site
99287008829	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
99287008830	putative DNA binding site [nucleotide binding]; other site
99287008831	putative metal binding site [ion binding]; other site
99287008832	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
99287008833	dimer interface [polypeptide binding]; other site
99287008834	active site
99287008835	metal binding site [ion binding]; metal-binding site
99287008836	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
99287008837	intersubunit interface [polypeptide binding]; other site
99287008838	active site
99287008839	Zn2+ binding site [ion binding]; other site
99287008840	L-fucose isomerase; Provisional; Region: fucI; PRK10991
99287008841	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
99287008842	hexamer (dimer of trimers) interface [polypeptide binding]; other site
99287008843	trimer interface [polypeptide binding]; other site
99287008844	substrate binding site [chemical binding]; other site
99287008845	Mn binding site [ion binding]; other site
99287008846	L-fuculokinase; Provisional; Region: PRK10331
99287008847	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
99287008848	nucleotide binding site [chemical binding]; other site
99287008849	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
99287008850	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
99287008851	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
99287008852	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287008853	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
99287008854	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
99287008855	hypothetical protein; Provisional; Region: PRK10873
99287008856	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
99287008857	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287008858	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
99287008859	dimerization interface [polypeptide binding]; other site
99287008860	substrate binding pocket [chemical binding]; other site
99287008861	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
99287008862	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
99287008863	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99287008864	catalytic residue [active]
99287008865	CsdA-binding activator; Provisional; Region: PRK15019
99287008866	Predicted permeases [General function prediction only]; Region: RarD; COG2962
99287008867	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
99287008868	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
99287008869	putative ATP binding site [chemical binding]; other site
99287008870	putative substrate interface [chemical binding]; other site
99287008871	murein transglycosylase A; Provisional; Region: mltA; PRK11162
99287008872	MltA specific insert domain; Region: MltA; smart00925
99287008873	3D domain; Region: 3D; pfam06725
99287008874	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
99287008875	AMIN domain; Region: AMIN; pfam11741
99287008876	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
99287008877	active site
99287008878	metal binding site [ion binding]; metal-binding site
99287008879	N-acetylglutamate synthase; Validated; Region: PRK05279
99287008880	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
99287008881	putative feedback inhibition sensing region; other site
99287008882	putative nucleotide binding site [chemical binding]; other site
99287008883	putative substrate binding site [chemical binding]; other site
99287008884	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287008885	Coenzyme A binding pocket [chemical binding]; other site
99287008886	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
99287008887	AAA domain; Region: AAA_30; pfam13604
99287008888	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
99287008889	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
99287008890	Protein of unknown function (DUF770); Region: DUF770; cl01402
99287008891	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
99287008892	protease3; Provisional; Region: PRK15101
99287008893	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
99287008894	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
99287008895	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
99287008896	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
99287008897	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
99287008898	hypothetical protein; Provisional; Region: PRK10332
99287008899	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
99287008900	hypothetical protein; Provisional; Region: PRK11521
99287008901	hypothetical protein; Provisional; Region: PRK10557
99287008902	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
99287008903	hypothetical protein; Provisional; Region: PRK10506
99287008904	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
99287008905	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
99287008906	dimerization interface [polypeptide binding]; other site
99287008907	active site
99287008908	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
99287008909	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
99287008910	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
99287008911	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
99287008912	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
99287008913	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
99287008914	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
99287008915	putative active site [active]
99287008916	Ap4A binding site [chemical binding]; other site
99287008917	nudix motif; other site
99287008918	putative metal binding site [ion binding]; other site
99287008919	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
99287008920	putative DNA-binding cleft [nucleotide binding]; other site
99287008921	putative DNA clevage site; other site
99287008922	molecular lever; other site
99287008923	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
99287008924	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
99287008925	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99287008926	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
99287008927	active site
99287008928	catalytic tetrad [active]
99287008929	lysophospholipid transporter LplT; Provisional; Region: PRK11195
99287008930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287008931	putative substrate translocation pore; other site
99287008932	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
99287008933	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
99287008934	putative acyl-acceptor binding pocket; other site
99287008935	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
99287008936	acyl-activating enzyme (AAE) consensus motif; other site
99287008937	putative AMP binding site [chemical binding]; other site
99287008938	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
99287008939	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287008940	DNA binding site [nucleotide binding]
99287008941	domain linker motif; other site
99287008942	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
99287008943	dimerization interface (closed form) [polypeptide binding]; other site
99287008944	ligand binding site [chemical binding]; other site
99287008945	Transcriptional regulators [Transcription]; Region: PurR; COG1609
99287008946	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287008947	DNA binding site [nucleotide binding]
99287008948	domain linker motif; other site
99287008949	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
99287008950	dimerization interface (closed form) [polypeptide binding]; other site
99287008951	ligand binding site [chemical binding]; other site
99287008952	diaminopimelate decarboxylase; Provisional; Region: PRK11165
99287008953	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
99287008954	active site
99287008955	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
99287008956	substrate binding site [chemical binding]; other site
99287008957	catalytic residues [active]
99287008958	dimer interface [polypeptide binding]; other site
99287008959	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
99287008960	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287008961	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287008962	dimerization interface [polypeptide binding]; other site
99287008963	putative racemase; Provisional; Region: PRK10200
99287008964	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
99287008965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287008966	putative substrate translocation pore; other site
99287008967	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
99287008968	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
99287008969	NADP binding site [chemical binding]; other site
99287008970	homodimer interface [polypeptide binding]; other site
99287008971	active site
99287008972	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
99287008973	putative acyltransferase; Provisional; Region: PRK05790
99287008974	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
99287008975	dimer interface [polypeptide binding]; other site
99287008976	active site
99287008977	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287008978	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287008979	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
99287008980	dimerization interface [polypeptide binding]; other site
99287008981	Predicted membrane protein [Function unknown]; Region: COG4125
99287008982	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
99287008983	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
99287008984	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
99287008985	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
99287008986	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
99287008987	putative metal binding site [ion binding]; other site
99287008988	putative homodimer interface [polypeptide binding]; other site
99287008989	putative homotetramer interface [polypeptide binding]; other site
99287008990	putative homodimer-homodimer interface [polypeptide binding]; other site
99287008991	putative allosteric switch controlling residues; other site
99287008992	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
99287008993	transcriptional activator SprB; Provisional; Region: PRK15320
99287008994	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
99287008995	Fimbrial protein; Region: Fimbrial; pfam00419
99287008996	fimbrial chaperone protein StdC; Provisional; Region: PRK15254
99287008997	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287008998	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287008999	fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255
99287009000	PapC N-terminal domain; Region: PapC_N; pfam13954
99287009001	Outer membrane usher protein; Region: Usher; pfam00577
99287009002	PapC C-terminal domain; Region: PapC_C; pfam13953
99287009003	fimbrial protein StdA; Provisional; Region: PRK15210
99287009004	hypothetical protein; Provisional; Region: PRK10316
99287009005	YfdX protein; Region: YfdX; pfam10938
99287009006	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
99287009007	Transposase IS200 like; Region: Y1_Tnp; pfam01797
99287009008	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99287009009	oligomeric interface; other site
99287009010	putative active site [active]
99287009011	homodimer interface [polypeptide binding]; other site
99287009012	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
99287009013	endonuclease; contains frameshifts
99287009014	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
99287009015	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
99287009016	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
99287009017	Peptidase family M23; Region: Peptidase_M23; pfam01551
99287009018	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
99287009019	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
99287009020	active site
99287009021	metal binding site [ion binding]; metal-binding site
99287009022	nudix motif; other site
99287009023	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
99287009024	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
99287009025	dimer interface [polypeptide binding]; other site
99287009026	putative anticodon binding site; other site
99287009027	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
99287009028	motif 1; other site
99287009029	active site
99287009030	motif 2; other site
99287009031	motif 3; other site
99287009032	peptide chain release factor 2; Validated; Region: prfB; PRK00578
99287009033	This domain is found in peptide chain release factors; Region: PCRF; smart00937
99287009034	RF-1 domain; Region: RF-1; pfam00472
99287009035	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
99287009036	DHH family; Region: DHH; pfam01368
99287009037	DHHA1 domain; Region: DHHA1; pfam02272
99287009038	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
99287009039	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
99287009040	dimerization domain [polypeptide binding]; other site
99287009041	dimer interface [polypeptide binding]; other site
99287009042	catalytic residues [active]
99287009043	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
99287009044	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
99287009045	active site
99287009046	Int/Topo IB signature motif; other site
99287009047	flavodoxin FldB; Provisional; Region: PRK12359
99287009048	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
99287009049	hypothetical protein; Provisional; Region: PRK10878
99287009050	putative global regulator; Reviewed; Region: PRK09559
99287009051	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
99287009052	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
99287009053	hemolysin; Provisional; Region: PRK15087
99287009054	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
99287009055	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
99287009056	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
99287009057	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
99287009058	glycine dehydrogenase; Provisional; Region: PRK05367
99287009059	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
99287009060	tetramer interface [polypeptide binding]; other site
99287009061	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287009062	catalytic residue [active]
99287009063	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
99287009064	tetramer interface [polypeptide binding]; other site
99287009065	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287009066	catalytic residue [active]
99287009067	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
99287009068	lipoyl attachment site [posttranslational modification]; other site
99287009069	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
99287009070	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
99287009071	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
99287009072	oxidoreductase; Provisional; Region: PRK08013
99287009073	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
99287009074	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
99287009075	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
99287009076	proline aminopeptidase P II; Provisional; Region: PRK10879
99287009077	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
99287009078	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
99287009079	active site
99287009080	hypothetical protein; Reviewed; Region: PRK01736
99287009081	Z-ring-associated protein; Provisional; Region: PRK10972
99287009082	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
99287009083	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
99287009084	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
99287009085	ligand binding site [chemical binding]; other site
99287009086	NAD binding site [chemical binding]; other site
99287009087	tetramer interface [polypeptide binding]; other site
99287009088	catalytic site [active]
99287009089	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
99287009090	L-serine binding site [chemical binding]; other site
99287009091	ACT domain interface; other site
99287009092	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
99287009093	tetramer (dimer of dimers) interface [polypeptide binding]; other site
99287009094	active site
99287009095	dimer interface [polypeptide binding]; other site
99287009096	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
99287009097	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287009098	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
99287009099	putative dimerization interface [polypeptide binding]; other site
99287009100	oxidative stress defense protein; Provisional; Region: PRK11087
99287009101	arginine exporter protein; Provisional; Region: PRK09304
99287009102	mechanosensitive channel MscS; Provisional; Region: PRK10334
99287009103	Mechanosensitive ion channel; Region: MS_channel; pfam00924
99287009104	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
99287009105	active site
99287009106	intersubunit interface [polypeptide binding]; other site
99287009107	zinc binding site [ion binding]; other site
99287009108	Na+ binding site [ion binding]; other site
99287009109	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
99287009110	substrate binding site [chemical binding]; other site
99287009111	hinge regions; other site
99287009112	ADP binding site [chemical binding]; other site
99287009113	catalytic site [active]
99287009114	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
99287009115	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
99287009116	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
99287009117	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
99287009118	trimer interface [polypeptide binding]; other site
99287009119	putative Zn binding site [ion binding]; other site
99287009120	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
99287009121	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
99287009122	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
99287009123	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
99287009124	Walker A/P-loop; other site
99287009125	ATP binding site [chemical binding]; other site
99287009126	Q-loop/lid; other site
99287009127	ABC transporter signature motif; other site
99287009128	Walker B; other site
99287009129	D-loop; other site
99287009130	H-loop/switch region; other site
99287009131	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
99287009132	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
99287009133	Walker A/P-loop; other site
99287009134	ATP binding site [chemical binding]; other site
99287009135	Q-loop/lid; other site
99287009136	ABC transporter signature motif; other site
99287009137	Walker B; other site
99287009138	D-loop; other site
99287009139	H-loop/switch region; other site
99287009140	transketolase; Reviewed; Region: PRK12753
99287009141	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
99287009142	TPP-binding site [chemical binding]; other site
99287009143	dimer interface [polypeptide binding]; other site
99287009144	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
99287009145	PYR/PP interface [polypeptide binding]; other site
99287009146	dimer interface [polypeptide binding]; other site
99287009147	TPP binding site [chemical binding]; other site
99287009148	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
99287009149	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
99287009150	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
99287009151	oligomer interface [polypeptide binding]; other site
99287009152	putative active site [active]
99287009153	Mn binding site [ion binding]; other site
99287009154	Putative lysophospholipase; Region: Hydrolase_4; cl19140
99287009155	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
99287009156	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
99287009157	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
99287009158	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
99287009159	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
99287009160	putative NAD(P) binding site [chemical binding]; other site
99287009161	catalytic Zn binding site [ion binding]; other site
99287009162	structural Zn binding site [ion binding]; other site
99287009163	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
99287009164	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
99287009165	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
99287009166	Transcriptional regulators [Transcription]; Region: FadR; COG2186
99287009167	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287009168	DNA-binding site [nucleotide binding]; DNA binding site
99287009169	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
99287009170	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
99287009171	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
99287009172	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
99287009173	dimer interface [polypeptide binding]; other site
99287009174	active site
99287009175	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
99287009176	catalytic residues [active]
99287009177	substrate binding site [chemical binding]; other site
99287009178	Virulence promoting factor; Region: YqgB; pfam11036
99287009179	cytoplasmic protein; contains frameshift with respect to similar proteins from Shigella flexneri and Escherichia coli
99287009180	Protein of unknown function (DUF2684); Region: DUF2684; pfam10885
99287009181	S-adenosylmethionine synthetase; Validated; Region: PRK05250
99287009182	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
99287009183	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
99287009184	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
99287009185	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
99287009186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287009187	putative substrate translocation pore; other site
99287009188	hypothetical protein; Provisional; Region: PRK04860
99287009189	DNA-specific endonuclease I; Provisional; Region: PRK15137
99287009190	RNA methyltransferase, RsmE family; Region: TIGR00046
99287009191	glutathione synthetase; Provisional; Region: PRK05246
99287009192	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
99287009193	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
99287009194	hypothetical protein; Validated; Region: PRK00228
99287009195	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
99287009196	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
99287009197	Transcriptional regulator [Transcription]; Region: IclR; COG1414
99287009198	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
99287009199	Walker A motif; other site
99287009200	ATP binding site [chemical binding]; other site
99287009201	Walker B motif; other site
99287009202	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
99287009203	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
99287009204	catalytic residue [active]
99287009205	YGGT family; Region: YGGT; pfam02325
99287009206	Predicted integral membrane protein [Function unknown]; Region: COG0762
99287009207	hypothetical protein; Validated; Region: PRK05090
99287009208	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
99287009209	active site
99287009210	dimerization interface [polypeptide binding]; other site
99287009211	HemN family oxidoreductase; Provisional; Region: PRK05660
99287009212	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287009213	FeS/SAM binding site; other site
99287009214	HemN C-terminal domain; Region: HemN_C; pfam06969
99287009215	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
99287009216	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
99287009217	active site
99287009218	homodimer interface [polypeptide binding]; other site
99287009219	hypothetical protein; Provisional; Region: PRK10626
99287009220	hypothetical protein; Provisional; Region: PRK11702
99287009221	Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220
99287009222	adenine DNA glycosylase; Provisional; Region: PRK10880
99287009223	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
99287009224	minor groove reading motif; other site
99287009225	helix-hairpin-helix signature motif; other site
99287009226	substrate binding pocket [chemical binding]; other site
99287009227	active site
99287009228	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
99287009229	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
99287009230	DNA binding and oxoG recognition site [nucleotide binding]
99287009231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924
99287009232	murein transglycosylase C; Provisional; Region: mltC; PRK11671
99287009233	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
99287009234	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
99287009235	N-acetyl-D-glucosamine binding site [chemical binding]; other site
99287009236	catalytic residue [active]
99287009237	nucleoside transporter; Region: 2A0110; TIGR00889
99287009238	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
99287009239	ornithine decarboxylase; Provisional; Region: PRK13578
99287009240	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
99287009241	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
99287009242	homodimer interface [polypeptide binding]; other site
99287009243	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287009244	catalytic residue [active]
99287009245	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
99287009246	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
99287009247	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
99287009248	dimer interface [polypeptide binding]; other site
99287009249	metal binding site [ion binding]; metal-binding site
99287009250	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
99287009251	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
99287009252	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
99287009253	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
99287009254	putative active site [active]
99287009255	putative catalytic site [active]
99287009256	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
99287009257	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
99287009258	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287009259	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
99287009260	putative dimerization interface [polypeptide binding]; other site
99287009261	putative substrate binding pocket [chemical binding]; other site
99287009262	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
99287009263	Sulfatase; Region: Sulfatase; pfam00884
99287009264	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
99287009265	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287009266	FeS/SAM binding site; other site
99287009267	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
99287009268	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99287009269	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287009270	DNA binding residues [nucleotide binding]
99287009271	dimerization interface [polypeptide binding]; other site
99287009272	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
99287009273	Amino acid permease; Region: AA_permease_2; pfam13520
99287009274	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
99287009275	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
99287009276	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
99287009277	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
99287009278	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
99287009279	NAD(P) binding site [chemical binding]; other site
99287009280	catalytic residues [active]
99287009281	DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128
99287009282	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
99287009283	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
99287009284	active site
99287009285	catalytic site [active]
99287009286	Zn binding site [ion binding]; other site
99287009287	tetramer interface [polypeptide binding]; other site
99287009288	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
99287009289	putative active site [active]
99287009290	catalytic triad [active]
99287009291	putative dimer interface [polypeptide binding]; other site
99287009292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287009293	D-galactonate transporter; Region: 2A0114; TIGR00893
99287009294	putative substrate translocation pore; other site
99287009295	mannonate dehydratase; Provisional; Region: PRK03906
99287009296	mannonate dehydratase; Region: uxuA; TIGR00695
99287009297	D-mannonate oxidoreductase; Provisional; Region: PRK15037
99287009298	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
99287009299	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
99287009300	glucuronate isomerase; Reviewed; Region: PRK02925
99287009301	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
99287009302	dimer interface [polypeptide binding]; other site
99287009303	putative CheW interface [polypeptide binding]; other site
99287009304	Chemoreceptor zinc-binding domain; Region: CZB; pfam13682
99287009305	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
99287009306	CHAP domain; Region: CHAP; pfam05257
99287009307	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
99287009308	putative S-transferase; Provisional; Region: PRK11752
99287009309	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
99287009310	C-terminal domain interface [polypeptide binding]; other site
99287009311	GSH binding site (G-site) [chemical binding]; other site
99287009312	dimer interface [polypeptide binding]; other site
99287009313	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
99287009314	dimer interface [polypeptide binding]; other site
99287009315	N-terminal domain interface [polypeptide binding]; other site
99287009316	active site
99287009317	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
99287009318	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
99287009319	putative ligand binding residues [chemical binding]; other site
99287009320	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
99287009321	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
99287009322	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
99287009323	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
99287009324	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
99287009325	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
99287009326	putative substrate-binding site; other site
99287009327	nickel binding site [ion binding]; other site
99287009328	hydrogenase 2 large subunit; Provisional; Region: PRK10467
99287009329	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
99287009330	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
99287009331	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
99287009332	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287009333	hydrogenase 2 small subunit; Provisional; Region: PRK10468
99287009334	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
99287009335	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
99287009336	NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720
99287009337	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
99287009338	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
99287009339	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287009340	dimerization interface [polypeptide binding]; other site
99287009341	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
99287009342	dimer interface [polypeptide binding]; other site
99287009343	putative CheW interface [polypeptide binding]; other site
99287009344	hypothetical protein; Provisional; Region: PRK05208
99287009345	oxidoreductase; Provisional; Region: PRK07985
99287009346	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
99287009347	NAD binding site [chemical binding]; other site
99287009348	metal binding site [ion binding]; metal-binding site
99287009349	active site
99287009350	biopolymer transport protein ExbD; Provisional; Region: PRK11267
99287009351	biopolymer transport protein ExbB; Provisional; Region: PRK10414
99287009352	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
99287009353	homodimer interface [polypeptide binding]; other site
99287009354	substrate-cofactor binding pocket; other site
99287009355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287009356	catalytic residue [active]
99287009357	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
99287009358	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
99287009359	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
99287009360	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287009361	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287009362	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
99287009363	dimer interface [polypeptide binding]; other site
99287009364	active site
99287009365	metal binding site [ion binding]; metal-binding site
99287009366	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
99287009367	active site
99287009368	catalytic tetrad [active]
99287009369	Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939
99287009370	anion transporter; Region: dass; TIGR00785
99287009371	transmembrane helices; other site
99287009372	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
99287009373	nucleotide binding site/active site [active]
99287009374	catalytic residue [active]
99287009375	hypothetical protein; Provisional; Region: PRK01254
99287009376	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
99287009377	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
99287009378	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
99287009379	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
99287009380	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
99287009381	DctM-like transporters; Region: DctM; pfam06808
99287009382	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
99287009383	FtsI repressor; Provisional; Region: PRK10883
99287009384	Sulfur oxidation protein SoxY; Region: SoxY; cl19207
99287009385	The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232
99287009386	Domain 2 interface [polypeptide binding]; other site
99287009387	Domain 3 interface [polypeptide binding]; other site
99287009388	trinuclear Cu binding site [ion binding]; other site
99287009389	The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867
99287009390	Domain 1 interface [polypeptide binding]; other site
99287009391	Domain 3 interface [polypeptide binding]; other site
99287009392	The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890
99287009393	Domain 2 interface [polypeptide binding]; other site
99287009394	Domain 1 interface [polypeptide binding]; other site
99287009395	Type 1 (T1) Cu binding site [ion binding]; other site
99287009396	trinuclear Cu binding site [ion binding]; other site
99287009397	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
99287009398	putative acyl-acceptor binding pocket; other site
99287009399	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
99287009400	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
99287009401	CAP-like domain; other site
99287009402	active site
99287009403	primary dimer interface [polypeptide binding]; other site
99287009404	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
99287009405	Helix-turn-helix domain; Region: HTH_18; pfam12833
99287009406	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287009407	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
99287009408	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
99287009409	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
99287009410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287009411	active site
99287009412	phosphorylation site [posttranslational modification]
99287009413	intermolecular recognition site; other site
99287009414	dimerization interface [polypeptide binding]; other site
99287009415	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287009416	DNA binding site [nucleotide binding]
99287009417	sensor protein QseC; Provisional; Region: PRK10337
99287009418	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287009419	dimer interface [polypeptide binding]; other site
99287009420	phosphorylation site [posttranslational modification]
99287009421	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287009422	ATP binding site [chemical binding]; other site
99287009423	Mg2+ binding site [ion binding]; other site
99287009424	G-X-G motif; other site
99287009425	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
99287009426	Uncharacterized conserved protein [Function unknown]; Region: COG1359
99287009427	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
99287009428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287009429	ATP binding site [chemical binding]; other site
99287009430	Mg2+ binding site [ion binding]; other site
99287009431	G-X-G motif; other site
99287009432	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
99287009433	anchoring element; other site
99287009434	dimer interface [polypeptide binding]; other site
99287009435	ATP binding site [chemical binding]; other site
99287009436	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
99287009437	active site
99287009438	metal binding site [ion binding]; metal-binding site
99287009439	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
99287009440	esterase YqiA; Provisional; Region: PRK11071
99287009441	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
99287009442	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
99287009443	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
99287009444	active site
99287009445	metal binding site [ion binding]; metal-binding site
99287009446	hexamer interface [polypeptide binding]; other site
99287009447	putative dehydrogenase; Provisional; Region: PRK11039
99287009448	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
99287009449	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
99287009450	dimer interface [polypeptide binding]; other site
99287009451	ADP-ribose binding site [chemical binding]; other site
99287009452	active site
99287009453	nudix motif; other site
99287009454	metal binding site [ion binding]; metal-binding site
99287009455	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
99287009456	Outer membrane efflux protein; Region: OEP; pfam02321
99287009457	Outer membrane efflux protein; Region: OEP; pfam02321
99287009458	hypothetical protein; Provisional; Region: PRK11653
99287009459	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
99287009460	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
99287009461	putative active site [active]
99287009462	metal binding site [ion binding]; metal-binding site
99287009463	zinc transporter ZupT; Provisional; Region: PRK04201
99287009464	Protein of unknown function (DUF4051); Region: DUF4051; pfam13260
99287009465	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
99287009466	catalytic residues [active]
99287009467	hinge region; other site
99287009468	alpha helical domain; other site
99287009469	putative disulfide oxidoreductase; Provisional; Region: PRK04307
99287009470	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
99287009471	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
99287009472	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
99287009473	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
99287009474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
99287009475	Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399
99287009476	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
99287009477	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
99287009478	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
99287009479	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
99287009480	putative ribose interaction site [chemical binding]; other site
99287009481	putative ADP binding site [chemical binding]; other site
99287009482	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
99287009483	active site
99287009484	nucleotide binding site [chemical binding]; other site
99287009485	HIGH motif; other site
99287009486	KMSKS motif; other site
99287009487	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
99287009488	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
99287009489	metal binding triad; other site
99287009490	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
99287009491	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
99287009492	metal binding triad; other site
99287009493	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627
99287009494	Uncharacterized conserved protein [Function unknown]; Region: COG3025
99287009495	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
99287009496	putative active site [active]
99287009497	putative metal binding residues [ion binding]; other site
99287009498	signature motif; other site
99287009499	putative triphosphate binding site [ion binding]; other site
99287009500	CHAD domain; Region: CHAD; pfam05235
99287009501	SH3 domain-containing protein; Provisional; Region: PRK10884
99287009502	Bacterial SH3 domain homologues; Region: SH3b; smart00287
99287009503	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
99287009504	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
99287009505	active site
99287009506	NTP binding site [chemical binding]; other site
99287009507	metal binding triad [ion binding]; metal-binding site
99287009508	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
99287009509	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
99287009510	Zn2+ binding site [ion binding]; other site
99287009511	Mg2+ binding site [ion binding]; other site
99287009512	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
99287009513	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
99287009514	homooctamer interface [polypeptide binding]; other site
99287009515	active site
99287009516	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
99287009517	UGMP family protein; Validated; Region: PRK09604
99287009518	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99287009519	nucleotide binding site [chemical binding]; other site
99287009520	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
99287009521	DNA primase; Validated; Region: dnaG; PRK05667
99287009522	CHC2 zinc finger; Region: zf-CHC2; pfam01807
99287009523	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
99287009524	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
99287009525	active site
99287009526	metal binding site [ion binding]; metal-binding site
99287009527	interdomain interaction site; other site
99287009528	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
99287009529	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
99287009530	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
99287009531	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
99287009532	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
99287009533	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
99287009534	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99287009535	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
99287009536	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99287009537	DNA binding residues [nucleotide binding]
99287009538	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
99287009539	active site
99287009540	SUMO-1 interface [polypeptide binding]; other site
99287009541	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
99287009542	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
99287009543	FAD binding pocket [chemical binding]; other site
99287009544	FAD binding motif [chemical binding]; other site
99287009545	phosphate binding motif [ion binding]; other site
99287009546	NAD binding pocket [chemical binding]; other site
99287009547	Predicted transcriptional regulators [Transcription]; Region: COG1695
99287009548	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
99287009549	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
99287009550	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287009551	dimerization interface [polypeptide binding]; other site
99287009552	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
99287009553	dimer interface [polypeptide binding]; other site
99287009554	putative CheW interface [polypeptide binding]; other site
99287009555	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99287009556	PAS fold; Region: PAS_3; pfam08447
99287009557	putative active site [active]
99287009558	heme pocket [chemical binding]; other site
99287009559	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
99287009560	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
99287009561	dimer interface [polypeptide binding]; other site
99287009562	putative CheW interface [polypeptide binding]; other site
99287009563	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
99287009564	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
99287009565	inhibitor-cofactor binding pocket; inhibition site
99287009566	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287009567	catalytic residue [active]
99287009568	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
99287009569	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
99287009570	active site
99287009571	FMN binding site [chemical binding]; other site
99287009572	2,4-decadienoyl-CoA binding site; other site
99287009573	catalytic residue [active]
99287009574	4Fe-4S cluster binding site [ion binding]; other site
99287009575	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287009576	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
99287009577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287009578	S-adenosylmethionine binding site [chemical binding]; other site
99287009579	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
99287009580	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
99287009581	putative active site [active]
99287009582	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
99287009583	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99287009584	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
99287009585	serine/threonine transporter SstT; Provisional; Region: PRK13628
99287009586	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
99287009587	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
99287009588	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
99287009589	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
99287009590	Predicted membrane protein [Function unknown]; Region: COG5393
99287009591	YqjK-like protein; Region: YqjK; pfam13997
99287009592	Predicted membrane protein [Function unknown]; Region: COG2259
99287009593	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
99287009594	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
99287009595	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
99287009596	putative dimer interface [polypeptide binding]; other site
99287009597	N-terminal domain interface [polypeptide binding]; other site
99287009598	putative substrate binding pocket (H-site) [chemical binding]; other site
99287009599	Predicted membrane protein [Function unknown]; Region: COG3152
99287009600	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287009601	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
99287009602	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287009603	dimerization interface [polypeptide binding]; other site
99287009604	Pirin-related protein [General function prediction only]; Region: COG1741
99287009605	Pirin; Region: Pirin; pfam02678
99287009606	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
99287009607	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
99287009608	serine transporter; Region: stp; TIGR00814
99287009609	L-serine dehydratase TdcG; Provisional; Region: PRK15040
99287009610	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
99287009611	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
99287009612	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
99287009613	Pyruvate formate lyase 1; Region: PFL1; cd01678
99287009614	coenzyme A binding site [chemical binding]; other site
99287009615	active site
99287009616	catalytic residues [active]
99287009617	glycine loop; other site
99287009618	propionate/acetate kinase; Provisional; Region: PRK12379
99287009619	threonine/serine transporter TdcC; Provisional; Region: PRK13629
99287009620	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
99287009621	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
99287009622	tetramer interface [polypeptide binding]; other site
99287009623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287009624	catalytic residue [active]
99287009625	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
99287009626	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287009627	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
99287009628	putative substrate binding pocket [chemical binding]; other site
99287009629	putative dimerization interface [polypeptide binding]; other site
99287009630	glycerate kinase I; Provisional; Region: PRK10342
99287009631	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
99287009632	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
99287009633	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
99287009634	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
99287009635	galactarate dehydratase; Region: galactar-dH20; TIGR03248
99287009636	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
99287009637	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
99287009638	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
99287009639	substrate binding site [chemical binding]; other site
99287009640	ATP binding site [chemical binding]; other site
99287009641	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
99287009642	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
99287009643	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287009644	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
99287009645	intersubunit interface [polypeptide binding]; other site
99287009646	active site
99287009647	zinc binding site [ion binding]; other site
99287009648	Na+ binding site [ion binding]; other site
99287009649	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
99287009650	putative substrate binding site [chemical binding]; other site
99287009651	putative ATP binding site [chemical binding]; other site
99287009652	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
99287009653	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
99287009654	active site
99287009655	P-loop; other site
99287009656	phosphorylation site [posttranslational modification]
99287009657	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
99287009658	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
99287009659	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
99287009660	active site
99287009661	phosphorylation site [posttranslational modification]
99287009662	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
99287009663	dimerization domain swap beta strand [polypeptide binding]; other site
99287009664	regulatory protein interface [polypeptide binding]; other site
99287009665	active site
99287009666	regulatory phosphorylation site [posttranslational modification]; other site
99287009667	D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052
99287009668	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
99287009669	active site
99287009670	phosphorylation site [posttranslational modification]
99287009671	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
99287009672	active site
99287009673	P-loop; other site
99287009674	phosphorylation site [posttranslational modification]
99287009675	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
99287009676	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
99287009677	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
99287009678	putative NAD(P) binding site [chemical binding]; other site
99287009679	catalytic Zn binding site [ion binding]; other site
99287009680	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
99287009681	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
99287009682	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287009683	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
99287009684	putative SAM binding site [chemical binding]; other site
99287009685	putative homodimer interface [polypeptide binding]; other site
99287009686	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
99287009687	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
99287009688	putative ligand binding site [chemical binding]; other site
99287009689	TIGR00252 family protein; Region: TIGR00252
99287009690	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
99287009691	dimer interface [polypeptide binding]; other site
99287009692	active site
99287009693	outer membrane lipoprotein; Provisional; Region: PRK11023
99287009694	BON domain; Region: BON; pfam04972
99287009695	BON domain; Region: BON; pfam04972
99287009696	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
99287009697	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
99287009698	NAD(P) binding site [chemical binding]; other site
99287009699	active site
99287009700	intracellular protease, PfpI family; Region: PfpI; TIGR01382
99287009701	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
99287009702	proposed catalytic triad [active]
99287009703	conserved cys residue [active]
99287009704	hypothetical protein; Provisional; Region: PRK03467
99287009705	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
99287009706	GIY-YIG motif/motif A; other site
99287009707	putative active site [active]
99287009708	putative metal binding site [ion binding]; other site
99287009709	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
99287009710	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287009711	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
99287009712	Coenzyme A binding pocket [chemical binding]; other site
99287009713	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
99287009714	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
99287009715	putative protease; Provisional; Region: PRK15447
99287009716	hypothetical protein; Provisional; Region: PRK10508
99287009717	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
99287009718	tryptophan permease; Provisional; Region: PRK10483
99287009719	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
99287009720	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
99287009721	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
99287009722	ATP binding site [chemical binding]; other site
99287009723	Mg++ binding site [ion binding]; other site
99287009724	motif III; other site
99287009725	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287009726	nucleotide binding region [chemical binding]; other site
99287009727	ATP-binding site [chemical binding]; other site
99287009728	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
99287009729	putative RNA binding site [nucleotide binding]; other site
99287009730	Cold shock protein DEAD box A; Region: DEADboxA; pfam12343
99287009731	lipoprotein NlpI; Provisional; Region: PRK11189
99287009732	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287009733	binding surface
99287009734	TPR motif; other site
99287009735	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
99287009736	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
99287009737	RNase E interface [polypeptide binding]; other site
99287009738	trimer interface [polypeptide binding]; other site
99287009739	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
99287009740	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
99287009741	RNase E interface [polypeptide binding]; other site
99287009742	trimer interface [polypeptide binding]; other site
99287009743	active site
99287009744	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
99287009745	putative nucleic acid binding region [nucleotide binding]; other site
99287009746	G-X-X-G motif; other site
99287009747	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
99287009748	RNA binding site [nucleotide binding]; other site
99287009749	domain interface; other site
99287009750	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
99287009751	16S/18S rRNA binding site [nucleotide binding]; other site
99287009752	S13e-L30e interaction site [polypeptide binding]; other site
99287009753	25S rRNA binding site [nucleotide binding]; other site
99287009754	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
99287009755	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
99287009756	RNA binding site [nucleotide binding]; other site
99287009757	active site
99287009758	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
99287009759	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
99287009760	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
99287009761	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
99287009762	translation initiation factor IF-2; Validated; Region: infB; PRK05306
99287009763	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
99287009764	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
99287009765	G1 box; other site
99287009766	putative GEF interaction site [polypeptide binding]; other site
99287009767	GTP/Mg2+ binding site [chemical binding]; other site
99287009768	Switch I region; other site
99287009769	G2 box; other site
99287009770	G3 box; other site
99287009771	Switch II region; other site
99287009772	G4 box; other site
99287009773	G5 box; other site
99287009774	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
99287009775	Translation-initiation factor 2; Region: IF-2; pfam11987
99287009776	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
99287009777	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
99287009778	NusA N-terminal domain; Region: NusA_N; pfam08529
99287009779	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
99287009780	RNA binding site [nucleotide binding]; other site
99287009781	homodimer interface [polypeptide binding]; other site
99287009782	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
99287009783	G-X-X-G motif; other site
99287009784	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
99287009785	G-X-X-G motif; other site
99287009786	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
99287009787	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
99287009788	hypothetical protein; Provisional; Region: PRK14641
99287009789	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
99287009790	putative oligomer interface [polypeptide binding]; other site
99287009791	putative RNA binding site [nucleotide binding]; other site
99287009792	argininosuccinate synthase; Validated; Region: PRK05370
99287009793	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
99287009794	Preprotein translocase SecG subunit; Region: SecG; pfam03840
99287009795	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
99287009796	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
99287009797	active site
99287009798	substrate binding site [chemical binding]; other site
99287009799	metal binding site [ion binding]; metal-binding site
99287009800	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
99287009801	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
99287009802	substrate binding pocket [chemical binding]; other site
99287009803	dimer interface [polypeptide binding]; other site
99287009804	inhibitor binding site; inhibition site
99287009805	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
99287009806	FtsH Extracellular; Region: FtsH_ext; pfam06480
99287009807	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287009808	Walker A motif; other site
99287009809	ATP binding site [chemical binding]; other site
99287009810	Walker B motif; other site
99287009811	arginine finger; other site
99287009812	Peptidase family M41; Region: Peptidase_M41; pfam01434
99287009813	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287009814	S-adenosylmethionine binding site [chemical binding]; other site
99287009815	RNA-binding protein YhbY; Provisional; Region: PRK10343
99287009816	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
99287009817	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
99287009818	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
99287009819	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
99287009820	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
99287009821	GTPase CgtA; Reviewed; Region: obgE; PRK12298
99287009822	GTP1/OBG; Region: GTP1_OBG; pfam01018
99287009823	Obg GTPase; Region: Obg; cd01898
99287009824	G1 box; other site
99287009825	GTP/Mg2+ binding site [chemical binding]; other site
99287009826	Switch I region; other site
99287009827	G2 box; other site
99287009828	G3 box; other site
99287009829	Switch II region; other site
99287009830	G4 box; other site
99287009831	G5 box; other site
99287009832	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
99287009833	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
99287009834	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
99287009835	substrate binding pocket [chemical binding]; other site
99287009836	chain length determination region; other site
99287009837	substrate-Mg2+ binding site; other site
99287009838	catalytic residues [active]
99287009839	aspartate-rich region 1; other site
99287009840	active site lid residues [active]
99287009841	aspartate-rich region 2; other site
99287009842	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
99287009843	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
99287009844	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
99287009845	hinge; other site
99287009846	active site
99287009847	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
99287009848	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
99287009849	anti sigma factor interaction site; other site
99287009850	regulatory phosphorylation site [posttranslational modification]; other site
99287009851	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
99287009852	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
99287009853	mce related protein; Region: MCE; pfam02470
99287009854	conserved hypothetical integral membrane protein; Region: TIGR00056
99287009855	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
99287009856	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
99287009857	Walker A/P-loop; other site
99287009858	ATP binding site [chemical binding]; other site
99287009859	Q-loop/lid; other site
99287009860	ABC transporter signature motif; other site
99287009861	Walker B; other site
99287009862	D-loop; other site
99287009863	H-loop/switch region; other site
99287009864	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
99287009865	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
99287009866	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
99287009867	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
99287009868	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
99287009869	putative active site [active]
99287009870	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
99287009871	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
99287009872	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
99287009873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
99287009874	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
99287009875	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
99287009876	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
99287009877	Walker A/P-loop; other site
99287009878	ATP binding site [chemical binding]; other site
99287009879	Q-loop/lid; other site
99287009880	ABC transporter signature motif; other site
99287009881	Walker B; other site
99287009882	D-loop; other site
99287009883	H-loop/switch region; other site
99287009884	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
99287009885	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
99287009886	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
99287009887	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
99287009888	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
99287009889	30S subunit binding site; other site
99287009890	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
99287009891	active site
99287009892	phosphorylation site [posttranslational modification]
99287009893	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
99287009894	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
99287009895	dimerization domain swap beta strand [polypeptide binding]; other site
99287009896	regulatory protein interface [polypeptide binding]; other site
99287009897	active site
99287009898	regulatory phosphorylation site [posttranslational modification]; other site
99287009899	hypothetical protein; Provisional; Region: PRK10345
99287009900	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
99287009901	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
99287009902	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
99287009903	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
99287009904	conserved cys residue [active]
99287009905	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
99287009906	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
99287009907	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99287009908	putative active site [active]
99287009909	heme pocket [chemical binding]; other site
99287009910	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287009911	dimer interface [polypeptide binding]; other site
99287009912	phosphorylation site [posttranslational modification]
99287009913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287009914	ATP binding site [chemical binding]; other site
99287009915	Mg2+ binding site [ion binding]; other site
99287009916	G-X-G motif; other site
99287009917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287009918	active site
99287009919	phosphorylation site [posttranslational modification]
99287009920	intermolecular recognition site; other site
99287009921	dimerization interface [polypeptide binding]; other site
99287009922	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
99287009923	putative binding surface; other site
99287009924	active site
99287009925	radical SAM protein, TIGR01212 family; Region: TIGR01212
99287009926	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287009927	FeS/SAM binding site; other site
99287009928	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
99287009929	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
99287009930	active site
99287009931	dimer interface [polypeptide binding]; other site
99287009932	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
99287009933	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
99287009934	active site
99287009935	FMN binding site [chemical binding]; other site
99287009936	substrate binding site [chemical binding]; other site
99287009937	3Fe-4S cluster binding site [ion binding]; other site
99287009938	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
99287009939	domain interface; other site
99287009940	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
99287009941	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
99287009942	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287009943	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99287009944	Protein of unknown function (DUF1016); Region: DUF1016; cl19557
99287009945	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
99287009946	Na binding site [ion binding]; other site
99287009947	putative substrate binding site [chemical binding]; other site
99287009948	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
99287009949	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
99287009950	active site
99287009951	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
99287009952	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
99287009953	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99287009954	nucleotide binding site [chemical binding]; other site
99287009955	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
99287009956	putative active site cavity [active]
99287009957	putative sialic acid transporter; Provisional; Region: PRK03893
99287009958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287009959	putative substrate translocation pore; other site
99287009960	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
99287009961	inhibitor site; inhibition site
99287009962	active site
99287009963	dimer interface [polypeptide binding]; other site
99287009964	catalytic residue [active]
99287009965	transcriptional regulator NanR; Provisional; Region: PRK03837
99287009966	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287009967	DNA-binding site [nucleotide binding]; DNA binding site
99287009968	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
99287009969	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
99287009970	stringent starvation protein A; Provisional; Region: sspA; PRK09481
99287009971	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
99287009972	C-terminal domain interface [polypeptide binding]; other site
99287009973	putative GSH binding site (G-site) [chemical binding]; other site
99287009974	dimer interface [polypeptide binding]; other site
99287009975	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
99287009976	dimer interface [polypeptide binding]; other site
99287009977	N-terminal domain interface [polypeptide binding]; other site
99287009978	Family of unknown function (DUF695); Region: DUF695; pfam05117
99287009979	Regulator of ribonuclease activity B; Region: RraB; pfam06877
99287009980	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
99287009981	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
99287009982	23S rRNA interface [nucleotide binding]; other site
99287009983	L3 interface [polypeptide binding]; other site
99287009984	Predicted ATPase [General function prediction only]; Region: COG1485
99287009985	hypothetical protein; Provisional; Region: PRK11677
99287009986	serine endoprotease; Provisional; Region: PRK10139
99287009987	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99287009988	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
99287009989	protein binding site [polypeptide binding]; other site
99287009990	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
99287009991	serine endoprotease; Provisional; Region: PRK10898
99287009992	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
99287009993	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
99287009994	protein binding site [polypeptide binding]; other site
99287009995	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
99287009996	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15477
99287009997	oxaloacetate decarboxylase; Provisional; Region: PRK14040
99287009998	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
99287009999	active site
99287010000	catalytic residues [active]
99287010001	metal binding site [ion binding]; metal-binding site
99287010002	homodimer binding site [polypeptide binding]; other site
99287010003	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
99287010004	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
99287010005	carboxyltransferase (CT) interaction site; other site
99287010006	biotinylation site [posttranslational modification]; other site
99287010007	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
99287010008	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
99287010009	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
99287010010	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
99287010011	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
99287010012	transmembrane helices; other site
99287010013	Transcriptional regulators [Transcription]; Region: GntR; COG1802
99287010014	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287010015	DNA-binding site [nucleotide binding]; DNA binding site
99287010016	FCD domain; Region: FCD; pfam07729
99287010017	Transcriptional regulators [Transcription]; Region: GntR; COG1802
99287010018	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
99287010019	DNA-binding site [nucleotide binding]; DNA binding site
99287010020	malate dehydrogenase; Provisional; Region: PRK05086
99287010021	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
99287010022	NAD binding site [chemical binding]; other site
99287010023	dimerization interface [polypeptide binding]; other site
99287010024	Substrate binding site [chemical binding]; other site
99287010025	arginine repressor; Provisional; Region: PRK05066
99287010026	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
99287010027	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
99287010028	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
99287010029	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
99287010030	Barstar, RNAse (barnase) inhibitor [Transcription]; Region: COG2732
99287010031	RNAase interaction site [polypeptide binding]; other site
99287010032	Predicted membrane protein [Function unknown]; Region: COG1289
99287010033	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
99287010034	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
99287010035	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99287010036	HlyD family secretion protein; Region: HlyD_3; pfam13437
99287010037	efflux system membrane protein; Provisional; Region: PRK11594
99287010038	transcriptional regulator; Provisional; Region: PRK10632
99287010039	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287010040	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
99287010041	putative effector binding pocket; other site
99287010042	dimerization interface [polypeptide binding]; other site
99287010043	protease TldD; Provisional; Region: tldD; PRK10735
99287010044	hypothetical protein; Provisional; Region: PRK10899
99287010045	Protein of unknown function; Region: DUF3971; pfam13116
99287010046	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
99287010047	ribonuclease G; Provisional; Region: PRK11712
99287010048	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
99287010049	homodimer interface [polypeptide binding]; other site
99287010050	oligonucleotide binding site [chemical binding]; other site
99287010051	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
99287010052	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
99287010053	active site
99287010054	dimer interface [polypeptide binding]; other site
99287010055	rod shape-determining protein MreD; Provisional; Region: PRK11060
99287010056	rod shape-determining protein MreC; Region: mreC; TIGR00219
99287010057	rod shape-determining protein MreB; Provisional; Region: PRK13927
99287010058	MreB and similar proteins; Region: MreB_like; cd10225
99287010059	nucleotide binding site [chemical binding]; other site
99287010060	Mg binding site [ion binding]; other site
99287010061	putative protofilament interaction site [polypeptide binding]; other site
99287010062	RodZ interaction site [polypeptide binding]; other site
99287010063	regulatory protein CsrD; Provisional; Region: PRK11059
99287010064	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
99287010065	metal binding site [ion binding]; metal-binding site
99287010066	nucleotidyl binding site; other site
99287010067	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287010068	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
99287010069	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
99287010070	NADP binding site [chemical binding]; other site
99287010071	dimer interface [polypeptide binding]; other site
99287010072	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
99287010073	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
99287010074	Moco binding site; other site
99287010075	metal coordination site [ion binding]; other site
99287010076	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
99287010077	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
99287010078	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
99287010079	carboxyltransferase (CT) interaction site; other site
99287010080	biotinylation site [posttranslational modification]; other site
99287010081	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
99287010082	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
99287010083	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
99287010084	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
99287010085	hypothetical protein; Provisional; Region: PRK10633
99287010086	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
99287010087	Na binding site [ion binding]; other site
99287010088	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
99287010089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287010090	S-adenosylmethionine binding site [chemical binding]; other site
99287010091	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
99287010092	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
99287010093	FMN binding site [chemical binding]; other site
99287010094	active site
99287010095	catalytic residues [active]
99287010096	substrate binding site [chemical binding]; other site
99287010097	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
99287010098	putative methyltransferase; Provisional; Region: PRK11524
99287010099	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287010100	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
99287010101	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
99287010102	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
99287010103	Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219
99287010104	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
99287010105	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99287010106	metal binding site [ion binding]; metal-binding site
99287010107	active site
99287010108	I-site; other site
99287010109	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287010110	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
99287010111	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287010112	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
99287010113	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
99287010114	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99287010115	HlyD family secretion protein; Region: HlyD_3; pfam13437
99287010116	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
99287010117	MMPL family; Region: MMPL; cl14618
99287010118	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
99287010119	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
99287010120	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
99287010121	trimer interface [polypeptide binding]; other site
99287010122	putative metal binding site [ion binding]; other site
99287010123	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
99287010124	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
99287010125	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
99287010126	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
99287010127	shikimate binding site; other site
99287010128	NAD(P) binding site [chemical binding]; other site
99287010129	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
99287010130	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
99287010131	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
99287010132	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
99287010133	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
99287010134	hypothetical protein; Validated; Region: PRK03430
99287010135	hypothetical protein; Provisional; Region: PRK10736
99287010136	DNA protecting protein DprA; Region: dprA; TIGR00732
99287010137	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
99287010138	active site
99287010139	catalytic residues [active]
99287010140	metal binding site [ion binding]; metal-binding site
99287010141	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
99287010142	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
99287010143	putative active site [active]
99287010144	substrate binding site [chemical binding]; other site
99287010145	putative cosubstrate binding site; other site
99287010146	catalytic site [active]
99287010147	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
99287010148	substrate binding site [chemical binding]; other site
99287010149	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
99287010150	putative RNA binding site [nucleotide binding]; other site
99287010151	16S rRNA methyltransferase B; Provisional; Region: PRK10901
99287010152	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287010153	S-adenosylmethionine binding site [chemical binding]; other site
99287010154	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
99287010155	TrkA-N domain; Region: TrkA_N; pfam02254
99287010156	TrkA-C domain; Region: TrkA_C; pfam02080
99287010157	TrkA-N domain; Region: TrkA_N; pfam02254
99287010158	TrkA-C domain; Region: TrkA_C; pfam02080
99287010159	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
99287010160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
99287010161	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
99287010162	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
99287010163	DNA binding residues [nucleotide binding]
99287010164	dimer interface [polypeptide binding]; other site
99287010165	metal binding site [ion binding]; metal-binding site
99287010166	hypothetical protein; Provisional; Region: PRK10203
99287010167	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
99287010168	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
99287010169	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
99287010170	alphaNTD homodimer interface [polypeptide binding]; other site
99287010171	alphaNTD - beta interaction site [polypeptide binding]; other site
99287010172	alphaNTD - beta' interaction site [polypeptide binding]; other site
99287010173	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
99287010174	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
99287010175	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
99287010176	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99287010177	RNA binding surface [nucleotide binding]; other site
99287010178	30S ribosomal protein S11; Validated; Region: PRK05309
99287010179	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
99287010180	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
99287010181	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
99287010182	SecY translocase; Region: SecY; pfam00344
99287010183	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
99287010184	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
99287010185	23S rRNA binding site [nucleotide binding]; other site
99287010186	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
99287010187	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
99287010188	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
99287010189	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
99287010190	23S rRNA interface [nucleotide binding]; other site
99287010191	5S rRNA interface [nucleotide binding]; other site
99287010192	L27 interface [polypeptide binding]; other site
99287010193	L5 interface [polypeptide binding]; other site
99287010194	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
99287010195	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
99287010196	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
99287010197	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
99287010198	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
99287010199	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
99287010200	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
99287010201	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
99287010202	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
99287010203	RNA binding site [nucleotide binding]; other site
99287010204	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
99287010205	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
99287010206	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
99287010207	23S rRNA interface [nucleotide binding]; other site
99287010208	putative translocon interaction site; other site
99287010209	signal recognition particle (SRP54) interaction site; other site
99287010210	L23 interface [polypeptide binding]; other site
99287010211	trigger factor interaction site; other site
99287010212	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
99287010213	23S rRNA interface [nucleotide binding]; other site
99287010214	5S rRNA interface [nucleotide binding]; other site
99287010215	putative antibiotic binding site [chemical binding]; other site
99287010216	L25 interface [polypeptide binding]; other site
99287010217	L27 interface [polypeptide binding]; other site
99287010218	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
99287010219	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
99287010220	G-X-X-G motif; other site
99287010221	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
99287010222	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
99287010223	protein-rRNA interface [nucleotide binding]; other site
99287010224	putative translocon binding site; other site
99287010225	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
99287010226	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
99287010227	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
99287010228	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
99287010229	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
99287010230	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
99287010231	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
99287010232	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
99287010233	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
99287010234	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
99287010235	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
99287010236	Ferritin-like domain; Region: Ferritin; pfam00210
99287010237	heme binding site [chemical binding]; other site
99287010238	ferroxidase pore; other site
99287010239	ferroxidase diiron center [ion binding]; other site
99287010240	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
99287010241	elongation factor Tu; Reviewed; Region: PRK00049
99287010242	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
99287010243	G1 box; other site
99287010244	GEF interaction site [polypeptide binding]; other site
99287010245	GTP/Mg2+ binding site [chemical binding]; other site
99287010246	Switch I region; other site
99287010247	G2 box; other site
99287010248	G3 box; other site
99287010249	Switch II region; other site
99287010250	G4 box; other site
99287010251	G5 box; other site
99287010252	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
99287010253	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
99287010254	Antibiotic Binding Site [chemical binding]; other site
99287010255	elongation factor G; Reviewed; Region: PRK00007
99287010256	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
99287010257	G1 box; other site
99287010258	putative GEF interaction site [polypeptide binding]; other site
99287010259	GTP/Mg2+ binding site [chemical binding]; other site
99287010260	Switch I region; other site
99287010261	G2 box; other site
99287010262	G3 box; other site
99287010263	Switch II region; other site
99287010264	G4 box; other site
99287010265	G5 box; other site
99287010266	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
99287010267	Elongation Factor G, domain II; Region: EFG_II; pfam14492
99287010268	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
99287010269	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
99287010270	30S ribosomal protein S7; Validated; Region: PRK05302
99287010271	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
99287010272	S17 interaction site [polypeptide binding]; other site
99287010273	S8 interaction site; other site
99287010274	16S rRNA interaction site [nucleotide binding]; other site
99287010275	streptomycin interaction site [chemical binding]; other site
99287010276	23S rRNA interaction site [nucleotide binding]; other site
99287010277	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
99287010278	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
99287010279	sulfur relay protein TusC; Validated; Region: PRK00211
99287010280	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
99287010281	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
99287010282	YheO-like PAS domain; Region: PAS_6; pfam08348
99287010283	HTH domain; Region: HTH_22; pfam13309
99287010284	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
99287010285	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
99287010286	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
99287010287	phi X174 lysis protein; Provisional; Region: PRK02793
99287010288	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737
99287010289	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
99287010290	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
99287010291	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
99287010292	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
99287010293	TrkA-N domain; Region: TrkA_N; pfam02254
99287010294	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
99287010295	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
99287010296	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
99287010297	ABC transporter; Region: ABC_tran_2; pfam12848
99287010298	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
99287010299	putative monooxygenase; Provisional; Region: PRK11118
99287010300	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
99287010301	putative hydrolase; Provisional; Region: PRK10985
99287010302	hypothetical protein; Provisional; Region: PRK04966
99287010303	phosphoribulokinase; Provisional; Region: PRK15453
99287010304	active site
99287010305	hypothetical protein; Provisional; Region: PRK10738
99287010306	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
99287010307	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
99287010308	ligand binding site [chemical binding]; other site
99287010309	flexible hinge region; other site
99287010310	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
99287010311	putative switch regulator; other site
99287010312	non-specific DNA interactions [nucleotide binding]; other site
99287010313	DNA binding site [nucleotide binding]
99287010314	sequence specific DNA binding site [nucleotide binding]; other site
99287010315	putative cAMP binding site [chemical binding]; other site
99287010316	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
99287010317	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
99287010318	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
99287010319	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
99287010320	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
99287010321	inhibitor-cofactor binding pocket; inhibition site
99287010322	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287010323	catalytic residue [active]
99287010324	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
99287010325	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
99287010326	glutamine binding [chemical binding]; other site
99287010327	catalytic triad [active]
99287010328	cell filamentation protein Fic; Provisional; Region: PRK10347
99287010329	hypothetical protein; Provisional; Region: PRK10204
99287010330	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
99287010331	substrate binding site [chemical binding]; other site
99287010332	putative transporter; Provisional; Region: PRK03699
99287010333	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287010334	putative substrate translocation pore; other site
99287010335	nitrite reductase subunit NirD; Provisional; Region: PRK14989
99287010336	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
99287010337	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
99287010338	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
99287010339	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
99287010340	nitrite transporter NirC; Provisional; Region: PRK11562
99287010341	siroheme synthase; Provisional; Region: cysG; PRK10637
99287010342	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
99287010343	Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824
99287010344	Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414
99287010345	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
99287010346	active site
99287010347	SAM binding site [chemical binding]; other site
99287010348	homodimer interface [polypeptide binding]; other site
99287010349	PPP4R2; Region: PPP4R2; pfam09184
99287010350	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; cl19417
99287010351	hypothetical protein; Provisional; Region: PRK09946
99287010352	Autotransporter beta-domain; Region: Autotransporter; pfam03797
99287010353	Transposase IS200 like; Region: Y1_Tnp; pfam01797
99287010354	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
99287010355	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
99287010356	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
99287010357	active site
99287010358	HIGH motif; other site
99287010359	dimer interface [polypeptide binding]; other site
99287010360	KMSKS motif; other site
99287010361	phosphoglycolate phosphatase; Provisional; Region: PRK13222
99287010362	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
99287010363	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287010364	motif II; other site
99287010365	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
99287010366	substrate binding site [chemical binding]; other site
99287010367	hexamer interface [polypeptide binding]; other site
99287010368	metal binding site [ion binding]; metal-binding site
99287010369	DNA adenine methylase; Provisional; Region: PRK10904
99287010370	cell division protein DamX; Validated; Region: PRK10905
99287010371	Sporulation related domain; Region: SPOR; pfam05036
99287010372	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
99287010373	active site
99287010374	dimer interface [polypeptide binding]; other site
99287010375	metal binding site [ion binding]; metal-binding site
99287010376	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
99287010377	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
99287010378	ADP binding site [chemical binding]; other site
99287010379	magnesium binding site [ion binding]; other site
99287010380	putative shikimate binding site; other site
99287010381	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
99287010382	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
99287010383	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
99287010384	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
99287010385	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
99287010386	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
99287010387	Transglycosylase; Region: Transgly; pfam00912
99287010388	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
99287010389	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
99287010390	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
99287010391	ADP-ribose binding site [chemical binding]; other site
99287010392	dimer interface [polypeptide binding]; other site
99287010393	active site
99287010394	nudix motif; other site
99287010395	metal binding site [ion binding]; metal-binding site
99287010396	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
99287010397	GMP/IMP nucleotidase; Provisional; Region: PRK14988
99287010398	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
99287010399	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287010400	motif II; other site
99287010401	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99287010402	RNA binding surface [nucleotide binding]; other site
99287010403	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
99287010404	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
99287010405	dimerization interface [polypeptide binding]; other site
99287010406	domain crossover interface; other site
99287010407	redox-dependent activation switch; other site
99287010408	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
99287010409	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
99287010410	active site
99287010411	substrate-binding site [chemical binding]; other site
99287010412	metal-binding site [ion binding]
99287010413	ATP binding site [chemical binding]; other site
99287010414	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
99287010415	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287010416	dimerization interface [polypeptide binding]; other site
99287010417	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287010418	dimer interface [polypeptide binding]; other site
99287010419	phosphorylation site [posttranslational modification]
99287010420	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287010421	ATP binding site [chemical binding]; other site
99287010422	Mg2+ binding site [ion binding]; other site
99287010423	G-X-G motif; other site
99287010424	osmolarity response regulator; Provisional; Region: ompR; PRK09468
99287010425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287010426	active site
99287010427	phosphorylation site [posttranslational modification]
99287010428	intermolecular recognition site; other site
99287010429	dimerization interface [polypeptide binding]; other site
99287010430	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287010431	DNA binding site [nucleotide binding]
99287010432	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
99287010433	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
99287010434	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
99287010435	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
99287010436	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
99287010437	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
99287010438	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
99287010439	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
99287010440	RNA binding site [nucleotide binding]; other site
99287010441	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
99287010442	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
99287010443	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
99287010444	G1 box; other site
99287010445	GTP/Mg2+ binding site [chemical binding]; other site
99287010446	Switch I region; other site
99287010447	G2 box; other site
99287010448	G3 box; other site
99287010449	Switch II region; other site
99287010450	G4 box; other site
99287010451	G5 box; other site
99287010452	Nucleoside recognition; Region: Gate; pfam07670
99287010453	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
99287010454	Nucleoside recognition; Region: Gate; pfam07670
99287010455	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
99287010456	hypothetical protein; Provisional; Region: PRK09956
99287010457	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
99287010458	carboxylesterase BioH; Provisional; Region: PRK10349
99287010459	Putative lysophospholipase; Region: Hydrolase_4; cl19140
99287010460	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
99287010461	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99287010462	active site
99287010463	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
99287010464	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
99287010465	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
99287010466	high-affinity gluconate transporter; Provisional; Region: PRK14984
99287010467	GntP family permease; Region: GntP_permease; pfam02447
99287010468	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
99287010469	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
99287010470	maltodextrin phosphorylase; Provisional; Region: PRK14985
99287010471	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
99287010472	homodimer interface [polypeptide binding]; other site
99287010473	active site pocket [active]
99287010474	transcriptional regulator MalT; Provisional; Region: PRK04841
99287010475	AAA ATPase domain; Region: AAA_16; pfam13191
99287010476	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287010477	DNA binding residues [nucleotide binding]
99287010478	dimerization interface [polypeptide binding]; other site
99287010479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
99287010480	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
99287010481	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
99287010482	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
99287010483	putative active site [active]
99287010484	adenylation catalytic residue [active]
99287010485	Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
99287010486	tRNA-splicing ligase RtcB; Region: RtcB; pfam01139
99287010487	TROVE domain; Region: TROVE; pfam05731
99287010488	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
99287010489	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
99287010490	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287010491	Walker A motif; other site
99287010492	ATP binding site [chemical binding]; other site
99287010493	Walker B motif; other site
99287010494	arginine finger; other site
99287010495	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
99287010496	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
99287010497	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287010498	intramembrane serine protease GlpG; Provisional; Region: PRK10907
99287010499	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
99287010500	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
99287010501	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
99287010502	active site residue [active]
99287010503	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
99287010504	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
99287010505	hypothetical protein; Provisional; Region: PRK09781
99287010506	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
99287010507	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
99287010508	dimer interface [polypeptide binding]; other site
99287010509	active site
99287010510	metal binding site [ion binding]; metal-binding site
99287010511	Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129
99287010512	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
99287010513	inhibitor site; inhibition site
99287010514	active site
99287010515	dimer interface [polypeptide binding]; other site
99287010516	catalytic residue [active]
99287010517	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
99287010518	Transcriptional regulator [Transcription]; Region: IclR; COG1414
99287010519	Bacterial transcriptional regulator; Region: IclR; pfam01614
99287010520	glycogen phosphorylase; Provisional; Region: PRK14986
99287010521	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
99287010522	homodimer interface [polypeptide binding]; other site
99287010523	active site pocket [active]
99287010524	glycogen synthase; Provisional; Region: glgA; PRK00654
99287010525	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
99287010526	ADP-binding pocket [chemical binding]; other site
99287010527	homodimer interface [polypeptide binding]; other site
99287010528	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
99287010529	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
99287010530	ligand binding site; other site
99287010531	oligomer interface; other site
99287010532	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
99287010533	dimer interface [polypeptide binding]; other site
99287010534	N-terminal domain interface [polypeptide binding]; other site
99287010535	sulfate 1 binding site; other site
99287010536	glycogen debranching enzyme; Provisional; Region: PRK03705
99287010537	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
99287010538	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
99287010539	active site
99287010540	catalytic site [active]
99287010541	glycogen branching enzyme; Provisional; Region: PRK05402
99287010542	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
99287010543	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
99287010544	active site
99287010545	catalytic site [active]
99287010546	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
99287010547	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
99287010548	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
99287010549	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
99287010550	low affinity gluconate transporter; Provisional; Region: PRK10472
99287010551	GntP family permease; Region: GntP_permease; pfam02447
99287010552	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
99287010553	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
99287010554	ATP-binding site [chemical binding]; other site
99287010555	Gluconate-6-phosphate binding site [chemical binding]; other site
99287010556	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
99287010557	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287010558	DNA binding site [nucleotide binding]
99287010559	domain linker motif; other site
99287010560	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
99287010561	putative ligand binding site [chemical binding]; other site
99287010562	putative dimerization interface [polypeptide binding]; other site
99287010563	Pirin-related protein [General function prediction only]; Region: COG1741
99287010564	Pirin; Region: Pirin; pfam02678
99287010565	putative oxidoreductase; Provisional; Region: PRK10206
99287010566	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99287010567	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
99287010568	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
99287010569	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287010570	Coenzyme A binding pocket [chemical binding]; other site
99287010571	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
99287010572	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
99287010573	substrate binding site [chemical binding]; other site
99287010574	dimer interface [polypeptide binding]; other site
99287010575	ATP binding site [chemical binding]; other site
99287010576	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
99287010577	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
99287010578	Protein of unknown function, DUF606; Region: DUF606; pfam04657
99287010579	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
99287010580	active site
99287010581	substrate binding pocket [chemical binding]; other site
99287010582	homodimer interaction site [polypeptide binding]; other site
99287010583	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
99287010584	hypothetical protein; Provisional; Region: PRK10350
99287010585	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
99287010586	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
99287010587	putative active site [active]
99287010588	catalytic site [active]
99287010589	putative metal binding site [ion binding]; other site
99287010590	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
99287010591	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
99287010592	Walker A/P-loop; other site
99287010593	ATP binding site [chemical binding]; other site
99287010594	Q-loop/lid; other site
99287010595	ABC transporter signature motif; other site
99287010596	Walker B; other site
99287010597	D-loop; other site
99287010598	H-loop/switch region; other site
99287010599	TOBE domain; Region: TOBE_2; pfam08402
99287010600	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
99287010601	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287010602	dimer interface [polypeptide binding]; other site
99287010603	conserved gate region; other site
99287010604	ABC-ATPase subunit interface; other site
99287010605	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
99287010606	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287010607	dimer interface [polypeptide binding]; other site
99287010608	conserved gate region; other site
99287010609	putative PBP binding loops; other site
99287010610	ABC-ATPase subunit interface; other site
99287010611	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
99287010612	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
99287010613	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
99287010614	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
99287010615	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
99287010616	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
99287010617	Walker A/P-loop; other site
99287010618	ATP binding site [chemical binding]; other site
99287010619	Q-loop/lid; other site
99287010620	ABC transporter signature motif; other site
99287010621	Walker B; other site
99287010622	D-loop; other site
99287010623	H-loop/switch region; other site
99287010624	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
99287010625	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
99287010626	Walker A/P-loop; other site
99287010627	ATP binding site [chemical binding]; other site
99287010628	Q-loop/lid; other site
99287010629	ABC transporter signature motif; other site
99287010630	Walker B; other site
99287010631	D-loop; other site
99287010632	H-loop/switch region; other site
99287010633	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
99287010634	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
99287010635	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
99287010636	TM-ABC transporter signature motif; other site
99287010637	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
99287010638	TM-ABC transporter signature motif; other site
99287010639	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
99287010640	dimerization interface [polypeptide binding]; other site
99287010641	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
99287010642	ligand binding site [chemical binding]; other site
99287010643	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
99287010644	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
99287010645	dimerization interface [polypeptide binding]; other site
99287010646	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
99287010647	ligand binding site [chemical binding]; other site
99287010648	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
99287010649	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
99287010650	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
99287010651	DNA binding residues [nucleotide binding]
99287010652	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
99287010653	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
99287010654	cell division protein FtsE; Provisional; Region: PRK10908
99287010655	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287010656	Walker A/P-loop; other site
99287010657	ATP binding site [chemical binding]; other site
99287010658	Q-loop/lid; other site
99287010659	ABC transporter signature motif; other site
99287010660	Walker B; other site
99287010661	D-loop; other site
99287010662	H-loop/switch region; other site
99287010663	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
99287010664	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
99287010665	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
99287010666	P loop; other site
99287010667	GTP binding site [chemical binding]; other site
99287010668	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287010669	S-adenosylmethionine binding site [chemical binding]; other site
99287010670	hypothetical protein; Provisional; Region: PRK10910
99287010671	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
99287010672	Predicted membrane protein [Function unknown]; Region: COG3714
99287010673	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
99287010674	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
99287010675	metal-binding site [ion binding]
99287010676	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99287010677	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
99287010678	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
99287010679	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
99287010680	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
99287010681	dimer interface [polypeptide binding]; other site
99287010682	ligand binding site [chemical binding]; other site
99287010683	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287010684	dimerization interface [polypeptide binding]; other site
99287010685	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
99287010686	dimer interface [polypeptide binding]; other site
99287010687	putative CheW interface [polypeptide binding]; other site
99287010688	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
99287010689	CPxP  motif; other site
99287010690	hypothetical protein; Provisional; Region: PRK11212
99287010691	hypothetical protein; Provisional; Region: PRK11615
99287010692	major facilitator superfamily transporter; Provisional; Region: PRK05122
99287010693	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287010694	putative substrate translocation pore; other site
99287010695	Domain of unknown function DUF20; Region: UPF0118; cl00465
99287010696	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
99287010697	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
99287010698	nickel responsive regulator; Provisional; Region: PRK02967
99287010699	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
99287010700	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
99287010701	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
99287010702	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
99287010703	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
99287010704	Walker A/P-loop; other site
99287010705	ATP binding site [chemical binding]; other site
99287010706	Q-loop/lid; other site
99287010707	ABC transporter signature motif; other site
99287010708	Walker B; other site
99287010709	D-loop; other site
99287010710	H-loop/switch region; other site
99287010711	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287010712	Walker A/P-loop; other site
99287010713	ATP binding site [chemical binding]; other site
99287010714	Q-loop/lid; other site
99287010715	ABC transporter signature motif; other site
99287010716	Walker B; other site
99287010717	D-loop; other site
99287010718	H-loop/switch region; other site
99287010719	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
99287010720	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
99287010721	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
99287010722	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
99287010723	HlyD family secretion protein; Region: HlyD_3; pfam13437
99287010724	Predicted flavoproteins [General function prediction only]; Region: COG2081
99287010725	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287010726	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
99287010727	universal stress protein UspB; Provisional; Region: PRK04960
99287010728	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
99287010729	Ligand Binding Site [chemical binding]; other site
99287010730	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
99287010731	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287010732	putative substrate translocation pore; other site
99287010733	putative methyltransferase; Provisional; Region: PRK10742
99287010734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287010735	S-adenosylmethionine binding site [chemical binding]; other site
99287010736	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
99287010737	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
99287010738	active site
99287010739	Zn binding site [ion binding]; other site
99287010740	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
99287010741	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
99287010742	active site
99287010743	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
99287010744	glutathione reductase; Validated; Region: PRK06116
99287010745	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287010746	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99287010747	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
99287010748	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
99287010749	active site
99287010750	homotetramer interface [polypeptide binding]; other site
99287010751	homodimer interface [polypeptide binding]; other site
99287010752	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
99287010753	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
99287010754	substrate binding site [chemical binding]; other site
99287010755	ATP binding site [chemical binding]; other site
99287010756	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
99287010757	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
99287010758	putative active site [active]
99287010759	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
99287010760	dimer interface [polypeptide binding]; other site
99287010761	active site
99287010762	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
99287010763	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287010764	DNA-binding site [nucleotide binding]; DNA binding site
99287010765	UTRA domain; Region: UTRA; pfam07702
99287010766	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
99287010767	trehalase; Provisional; Region: treF; PRK13270
99287010768	Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772
99287010769	catalytic residue [active]
99287010770	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99287010771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
99287010772	active site
99287010773	phosphorylation site [posttranslational modification]
99287010774	dimerization interface [polypeptide binding]; other site
99287010775	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287010776	DNA binding residues [nucleotide binding]
99287010777	dimerization interface [polypeptide binding]; other site
99287010778	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287010779	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287010780	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
99287010781	putative effector binding pocket; other site
99287010782	putative dimerization interface [polypeptide binding]; other site
99287010783	inner membrane protein YhjD; Region: TIGR00766
99287010784	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287010785	metabolite-proton symporter; Region: 2A0106; TIGR00883
99287010786	putative substrate translocation pore; other site
99287010787	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
99287010788	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
99287010789	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287010790	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
99287010791	substrate binding site [chemical binding]; other site
99287010792	ATP binding site [chemical binding]; other site
99287010793	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
99287010794	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
99287010795	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
99287010796	putative diguanylate cyclase; Provisional; Region: PRK13561
99287010797	HAMP domain; Region: HAMP; pfam00672
99287010798	diguanylate cyclase; Region: GGDEF; smart00267
99287010799	metal binding site [ion binding]; metal-binding site
99287010800	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287010801	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
99287010802	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287010803	TPR motif; other site
99287010804	binding surface
99287010805	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287010806	TPR motif; other site
99287010807	binding surface
99287010808	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287010809	binding surface
99287010810	TPR motif; other site
99287010811	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
99287010812	endo-1,4-D-glucanase; Provisional; Region: PRK11097
99287010813	cellulose synthase regulator protein; Provisional; Region: PRK11114
99287010814	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
99287010815	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99287010816	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
99287010817	DXD motif; other site
99287010818	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99287010819	PilZ domain; Region: PilZ; pfam07238
99287010820	cell division protein; Provisional; Region: PRK10037
99287010821	YhjQ protein; Region: YhjQ; pfam06564
99287010822	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
99287010823	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
99287010824	Protein of unknown function (DUF2636); Region: DUF2636; pfam11120
99287010825	cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368
99287010826	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
99287010827	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
99287010828	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
99287010829	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
99287010830	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99287010831	Walker A/P-loop; other site
99287010832	ATP binding site [chemical binding]; other site
99287010833	Q-loop/lid; other site
99287010834	ABC transporter signature motif; other site
99287010835	Walker B; other site
99287010836	D-loop; other site
99287010837	H-loop/switch region; other site
99287010838	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
99287010839	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
99287010840	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
99287010841	Walker A/P-loop; other site
99287010842	ATP binding site [chemical binding]; other site
99287010843	Q-loop/lid; other site
99287010844	ABC transporter signature motif; other site
99287010845	Walker B; other site
99287010846	D-loop; other site
99287010847	H-loop/switch region; other site
99287010848	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
99287010849	dipeptide transporter; Provisional; Region: PRK10913
99287010850	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
99287010851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287010852	dimer interface [polypeptide binding]; other site
99287010853	conserved gate region; other site
99287010854	putative PBP binding loops; other site
99287010855	ABC-ATPase subunit interface; other site
99287010856	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
99287010857	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287010858	dimer interface [polypeptide binding]; other site
99287010859	conserved gate region; other site
99287010860	putative PBP binding loops; other site
99287010861	ABC-ATPase subunit interface; other site
99287010862	antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109
99287010863	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
99287010864	peptide binding site [polypeptide binding]; other site
99287010865	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
99287010866	Sulfate transporter family; Region: Sulfate_transp; cl19250
99287010867	Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972
99287010868	Transcriptional regulators [Transcription]; Region: PurR; COG1609
99287010869	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287010870	DNA binding site [nucleotide binding]
99287010871	domain linker motif; other site
99287010872	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287
99287010873	putative dimerization interface [polypeptide binding]; other site
99287010874	putative ligand binding site [chemical binding]; other site
99287010875	phosphoethanolamine transferase; Provisional; Region: PRK11560
99287010876	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
99287010877	Sulfatase; Region: Sulfatase; pfam00884
99287010878	long polar fimbrial protein LpfE; Provisional; Region: PRK15205
99287010879	long polar fimbrial protein LpfD; Provisional; Region: PRK15206
99287010880	long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207
99287010881	PapC N-terminal domain; Region: PapC_N; pfam13954
99287010882	Outer membrane usher protein; Region: Usher; pfam00577
99287010883	PapC C-terminal domain; Region: PapC_C; pfam13953
99287010884	long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208
99287010885	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287010886	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287010887	long polar fimbrial protein LpfA; Provisional; Region: PRK15209
99287010888	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
99287010889	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
99287010890	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
99287010891	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287010892	Coenzyme A binding pocket [chemical binding]; other site
99287010893	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
99287010894	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
99287010895	molybdopterin cofactor binding site [chemical binding]; other site
99287010896	substrate binding site [chemical binding]; other site
99287010897	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
99287010898	molybdopterin cofactor binding site; other site
99287010899	putative outer membrane lipoprotein; Provisional; Region: PRK10510
99287010900	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
99287010901	ligand binding site [chemical binding]; other site
99287010902	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
99287010903	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
99287010904	dimerization interface [polypeptide binding]; other site
99287010905	ligand binding site [chemical binding]; other site
99287010906	NADP binding site [chemical binding]; other site
99287010907	catalytic site [active]
99287010908	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
99287010909	Predicted transcriptional regulator [Transcription]; Region: COG2944
99287010910	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287010911	salt bridge; other site
99287010912	non-specific DNA binding site [nucleotide binding]; other site
99287010913	sequence-specific DNA binding site [nucleotide binding]; other site
99287010914	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
99287010915	DNA-binding site [nucleotide binding]; DNA binding site
99287010916	RNA-binding motif; other site
99287010917	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
99287010918	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
99287010919	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
99287010920	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287010921	Coenzyme A binding pocket [chemical binding]; other site
99287010922	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
99287010923	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
99287010924	DALR anticodon binding domain; Region: DALR_1; pfam05746
99287010925	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
99287010926	dimer interface [polypeptide binding]; other site
99287010927	motif 1; other site
99287010928	active site
99287010929	motif 2; other site
99287010930	motif 3; other site
99287010931	YsaB-like lipoprotein; Region: YsaB; pfam13983
99287010932	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
99287010933	Predicted membrane protein [Function unknown]; Region: COG4682
99287010934	yiaA/B two helix domain; Region: YiaAB; pfam05360
99287010935	yiaA/B two helix domain; Region: YiaAB; cl01759
99287010936	xylulokinase; Provisional; Region: PRK15027
99287010937	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
99287010938	N- and C-terminal domain interface [polypeptide binding]; other site
99287010939	active site
99287010940	MgATP binding site [chemical binding]; other site
99287010941	catalytic site [active]
99287010942	metal binding site [ion binding]; metal-binding site
99287010943	xylulose binding site [chemical binding]; other site
99287010944	homodimer interface [polypeptide binding]; other site
99287010945	xylose isomerase; Provisional; Region: PRK05474
99287010946	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
99287010947	putative dimerization interface [polypeptide binding]; other site
99287010948	Transcriptional regulators [Transcription]; Region: PurR; COG1609
99287010949	putative ligand binding site [chemical binding]; other site
99287010950	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287010951	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99287010952	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287010953	hypothetical protein; Provisional; Region: PRK10356
99287010954	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
99287010955	alpha-amylase; Reviewed; Region: malS; PRK09505
99287010956	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
99287010957	active site
99287010958	catalytic site [active]
99287010959	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
99287010960	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99287010961	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287010962	homodimer interface [polypeptide binding]; other site
99287010963	catalytic residue [active]
99287010964	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
99287010965	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
99287010966	Transcriptional regulator [Transcription]; Region: IclR; COG1414
99287010967	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
99287010968	Bacterial transcriptional regulator; Region: IclR; pfam01614
99287010969	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
99287010970	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
99287010971	2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877
99287010972	L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060
99287010973	DctM-like transporters; Region: DctM; pfam06808
99287010974	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
99287010975	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
99287010976	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
99287010977	putative N- and C-terminal domain interface [polypeptide binding]; other site
99287010978	putative active site [active]
99287010979	MgATP binding site [chemical binding]; other site
99287010980	catalytic site [active]
99287010981	metal binding site [ion binding]; metal-binding site
99287010982	putative xylulose binding site [chemical binding]; other site
99287010983	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
99287010984	active site
99287010985	dimer interface [polypeptide binding]; other site
99287010986	magnesium binding site [ion binding]; other site
99287010987	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
99287010988	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
99287010989	AP (apurinic/apyrimidinic) site pocket; other site
99287010990	DNA interaction; other site
99287010991	Metal-binding active site; metal-binding site
99287010992	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
99287010993	intersubunit interface [polypeptide binding]; other site
99287010994	active site
99287010995	Zn2+ binding site [ion binding]; other site
99287010996	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
99287010997	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
99287010998	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287010999	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
99287011000	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559
99287011001	NAD(P) binding site [chemical binding]; other site
99287011002	catalytic residues [active]
99287011003	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
99287011004	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
99287011005	nucleotide binding site [chemical binding]; other site
99287011006	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
99287011007	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
99287011008	G1 box; other site
99287011009	putative GEF interaction site [polypeptide binding]; other site
99287011010	GTP/Mg2+ binding site [chemical binding]; other site
99287011011	Switch I region; other site
99287011012	G2 box; other site
99287011013	G3 box; other site
99287011014	Switch II region; other site
99287011015	G4 box; other site
99287011016	G5 box; other site
99287011017	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
99287011018	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
99287011019	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
99287011020	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
99287011021	selenocysteine synthase; Provisional; Region: PRK04311
99287011022	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
99287011023	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
99287011024	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99287011025	catalytic residue [active]
99287011026	putative glutathione S-transferase; Provisional; Region: PRK10357
99287011027	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
99287011028	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
99287011029	dimer interface [polypeptide binding]; other site
99287011030	N-terminal domain interface [polypeptide binding]; other site
99287011031	putative substrate binding pocket (H-site) [chemical binding]; other site
99287011032	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
99287011033	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
99287011034	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
99287011035	active site
99287011036	P-loop; other site
99287011037	phosphorylation site [posttranslational modification]
99287011038	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
99287011039	active site
99287011040	phosphorylation site [posttranslational modification]
99287011041	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
99287011042	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
99287011043	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
99287011044	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
99287011045	hypothetical protein; Provisional; Region: PRK11020
99287011046	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
99287011047	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
99287011048	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
99287011049	trimer interface [polypeptide binding]; other site
99287011050	Predicted membrane protein [Function unknown]; Region: COG1511
99287011051	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
99287011052	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
99287011053	Coiled stalk of trimeric autotransporter adhesin; Region: YadA_stalk; pfam05662
99287011054	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
99287011055	trimer interface [polypeptide binding]; other site
99287011056	Coiled stalk of trimeric autotransporter adhesin; Region: YadA_stalk; pfam05662
99287011057	YadA-like C-terminal region; Region: YadA_anchor; pfam03895
99287011058	L-lactate permease; Provisional; Region: PRK10420
99287011059	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
99287011060	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287011061	DNA-binding site [nucleotide binding]; DNA binding site
99287011062	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
99287011063	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
99287011064	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
99287011065	active site
99287011066	substrate binding site [chemical binding]; other site
99287011067	FMN binding site [chemical binding]; other site
99287011068	putative catalytic residues [active]
99287011069	putative rRNA methylase; Provisional; Region: PRK10358
99287011070	Transcriptional regulators [Transcription]; Region: PurR; COG1609
99287011071	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287011072	DNA binding site [nucleotide binding]
99287011073	domain linker motif; other site
99287011074	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
99287011075	putative dimerization interface [polypeptide binding]; other site
99287011076	putative ligand binding site [chemical binding]; other site
99287011077	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
99287011078	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
99287011079	active site pocket [active]
99287011080	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287011081	D-galactonate transporter; Region: 2A0114; TIGR00893
99287011082	putative substrate translocation pore; other site
99287011083	serine acetyltransferase; Provisional; Region: cysE; PRK11132
99287011084	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
99287011085	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
99287011086	trimer interface [polypeptide binding]; other site
99287011087	active site
99287011088	substrate binding site [chemical binding]; other site
99287011089	CoA binding site [chemical binding]; other site
99287011090	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
99287011091	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
99287011092	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
99287011093	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
99287011094	SecA binding site; other site
99287011095	Preprotein binding site; other site
99287011096	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
99287011097	GSH binding site [chemical binding]; other site
99287011098	catalytic residues [active]
99287011099	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
99287011100	active site residue [active]
99287011101	phosphoglyceromutase; Provisional; Region: PRK05434
99287011102	AmiB activator; Provisional; Region: PRK11637
99287011103	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
99287011104	Peptidase family M23; Region: Peptidase_M23; pfam01551
99287011105	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
99287011106	NodB motif; other site
99287011107	putative active site [active]
99287011108	putative catalytic site [active]
99287011109	Zn binding site [ion binding]; other site
99287011110	putative glycosyl transferase; Provisional; Region: PRK10073
99287011111	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
99287011112	active site
99287011113	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
99287011114	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
99287011115	NAD(P) binding site [chemical binding]; other site
99287011116	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
99287011117	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
99287011118	substrate-cofactor binding pocket; other site
99287011119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287011120	catalytic residue [active]
99287011121	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
99287011122	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
99287011123	NADP binding site [chemical binding]; other site
99287011124	homopentamer interface [polypeptide binding]; other site
99287011125	substrate binding site [chemical binding]; other site
99287011126	active site
99287011127	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
99287011128	putative active site [active]
99287011129	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
99287011130	putative active site [active]
99287011131	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
99287011132	O-antigen ligase RfaL; Provisional; Region: PRK15487
99287011133	lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484
99287011134	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99287011135	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
99287011136	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176
99287011137	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
99287011138	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
99287011139	Ligand binding site; other site
99287011140	metal-binding site
99287011141	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
99287011142	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
99287011143	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
99287011144	Ligand binding site; other site
99287011145	metal-binding site
99287011146	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
99287011147	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
99287011148	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
99287011149	putative ADP-binding pocket [chemical binding]; other site
99287011150	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
99287011151	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99287011152	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
99287011153	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
99287011154	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
99287011155	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
99287011156	putative active site [active]
99287011157	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
99287011158	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
99287011159	Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138
99287011160	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
99287011161	active site
99287011162	(T/H)XGH motif; other site
99287011163	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
99287011164	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
99287011165	DNA binding site [nucleotide binding]
99287011166	catalytic residue [active]
99287011167	H2TH interface [polypeptide binding]; other site
99287011168	putative catalytic residues [active]
99287011169	turnover-facilitating residue; other site
99287011170	intercalation triad [nucleotide binding]; other site
99287011171	8OG recognition residue [nucleotide binding]; other site
99287011172	putative reading head residues; other site
99287011173	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
99287011174	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
99287011175	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
99287011176	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
99287011177	hypothetical protein; Reviewed; Region: PRK00024
99287011178	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
99287011179	MPN+ (JAMM) motif; other site
99287011180	Zinc-binding site [ion binding]; other site
99287011181	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
99287011182	Flavoprotein; Region: Flavoprotein; cl19190
99287011183	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
99287011184	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
99287011185	trimer interface [polypeptide binding]; other site
99287011186	active site
99287011187	division inhibitor protein; Provisional; Region: slmA; PRK09480
99287011188	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287011189	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
99287011190	active site
99287011191	ribonuclease PH; Reviewed; Region: rph; PRK00173
99287011192	Ribonuclease PH; Region: RNase_PH_bact; cd11362
99287011193	hexamer interface [polypeptide binding]; other site
99287011194	active site
99287011195	hypothetical protein; Provisional; Region: PRK11820
99287011196	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
99287011197	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
99287011198	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287011199	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287011200	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287011201	dimerization interface [polypeptide binding]; other site
99287011202	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
99287011203	Predicted membrane protein [Function unknown]; Region: COG2860
99287011204	UPF0126 domain; Region: UPF0126; pfam03458
99287011205	UPF0126 domain; Region: UPF0126; pfam03458
99287011206	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
99287011207	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
99287011208	nucleotide binding pocket [chemical binding]; other site
99287011209	K-X-D-G motif; other site
99287011210	catalytic site [active]
99287011211	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
99287011212	Guanylate kinase; Region: Guanylate_kin; pfam00625
99287011213	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
99287011214	catalytic site [active]
99287011215	G-X2-G-X-G-K; other site
99287011216	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
99287011217	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
99287011218	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
99287011219	Zn2+ binding site [ion binding]; other site
99287011220	Mg2+ binding site [ion binding]; other site
99287011221	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
99287011222	synthetase active site [active]
99287011223	NTP binding site [chemical binding]; other site
99287011224	metal binding site [ion binding]; metal-binding site
99287011225	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
99287011226	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
99287011227	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
99287011228	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
99287011229	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
99287011230	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
99287011231	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
99287011232	generic binding surface II; other site
99287011233	ssDNA binding site; other site
99287011234	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99287011235	ATP binding site [chemical binding]; other site
99287011236	putative Mg++ binding site [ion binding]; other site
99287011237	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287011238	nucleotide binding region [chemical binding]; other site
99287011239	ATP-binding site [chemical binding]; other site
99287011240	Sodium/glutamate symporter; Region: Glt_symporter; cl19414
99287011241	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
99287011242	Sulfate transporter family; Region: Sulfate_transp; cl19250
99287011243	AsmA family; Region: AsmA; pfam05170
99287011244	putative alpha-glucosidase; Provisional; Region: PRK10658
99287011245	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
99287011246	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
99287011247	active site
99287011248	homotrimer interface [polypeptide binding]; other site
99287011249	catalytic site [active]
99287011250	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
99287011251	putative transporter; Provisional; Region: PRK11462
99287011252	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
99287011253	SPI-3; Salmonella pathogenicity island 3; required for intramacrophage survival and growth in low magnesium
99287011254	AAA ATPase domain; Region: AAA_15; pfam13175
99287011255	AAA domain; Region: AAA_23; pfam13476
99287011256	Walker A/P-loop; other site
99287011257	ATP binding site [chemical binding]; other site
99287011258	AAA domain; Region: AAA_21; pfam13304
99287011259	Methyltransferase domain; Region: Methyltransf_27; pfam13708
99287011260	Virulence protein [General function prediction only]; Region: COG3943
99287011261	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
99287011262	autotransport protein MisL; Provisional; Region: PRK15313
99287011263	hypothetical protein; Provisional; Region: PRK09946
99287011264	tail sheath protein; Provisional; Region: 18; PHA02539
99287011265	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
99287011266	Autotransporter beta-domain; Region: Autotransporter; pfam03797
99287011267	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
99287011268	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
99287011269	DNA binding site [nucleotide binding]
99287011270	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
99287011271	catalytic triad [active]
99287011272	conserved cis-peptide bond; other site
99287011273	magnesium-transporting ATPase; Provisional; Region: PRK15122
99287011274	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
99287011275	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99287011276	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
99287011277	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287011278	active site
99287011279	motif I; other site
99287011280	motif II; other site
99287011281	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
99287011282	magnesium transport protein MgtC; Provisional; Region: PRK15385
99287011283	MgtC family; Region: MgtC; pfam02308
99287011284	EamA-like transporter family; Region: EamA; pfam00892
99287011285	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
99287011286	EamA-like transporter family; Region: EamA; pfam00892
99287011287	hypothetical protein; Provisional; Region: PRK09956
99287011288	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
99287011289	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
99287011290	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
99287011291	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
99287011292	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
99287011293	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
99287011294	active site
99287011295	phosphorylation site [posttranslational modification]
99287011296	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
99287011297	active pocket/dimerization site; other site
99287011298	active site
99287011299	phosphorylation site [posttranslational modification]
99287011300	Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640
99287011301	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
99287011302	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287011303	Walker A motif; other site
99287011304	ATP binding site [chemical binding]; other site
99287011305	Walker B motif; other site
99287011306	arginine finger; other site
99287011307	Transcriptional antiterminator [Transcription]; Region: COG3933
99287011308	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
99287011309	active site
99287011310	active pocket/dimerization site; other site
99287011311	phosphorylation site [posttranslational modification]
99287011312	PRD domain; Region: PRD; pfam00874
99287011313	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
99287011314	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
99287011315	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
99287011316	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287011317	putative substrate translocation pore; other site
99287011318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737
99287011319	Predicted transcriptional regulator [Transcription]; Region: COG2944
99287011320	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287011321	non-specific DNA binding site [nucleotide binding]; other site
99287011322	salt bridge; other site
99287011323	sequence-specific DNA binding site [nucleotide binding]; other site
99287011324	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
99287011325	dimerization domain swap beta strand [polypeptide binding]; other site
99287011326	regulatory protein interface [polypeptide binding]; other site
99287011327	active site
99287011328	regulatory phosphorylation site [posttranslational modification]; other site
99287011329	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
99287011330	intersubunit interface [polypeptide binding]; other site
99287011331	active site
99287011332	zinc binding site [ion binding]; other site
99287011333	Na+ binding site [ion binding]; other site
99287011334	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
99287011335	uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774
99287011336	putative N- and C-terminal domain interface [polypeptide binding]; other site
99287011337	putative active site [active]
99287011338	putative MgATP binding site [chemical binding]; other site
99287011339	catalytic site [active]
99287011340	metal binding site [ion binding]; metal-binding site
99287011341	putative carbohydrate binding site [chemical binding]; other site
99287011342	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
99287011343	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
99287011344	active site
99287011345	P-loop; other site
99287011346	phosphorylation site [posttranslational modification]
99287011347	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
99287011348	active site
99287011349	phosphorylation site [posttranslational modification]
99287011350	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
99287011351	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287011352	DNA-binding site [nucleotide binding]; DNA binding site
99287011353	UTRA domain; Region: UTRA; pfam07702
99287011354	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
99287011355	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
99287011356	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287011357	putative substrate translocation pore; other site
99287011358	regulatory protein UhpC; Provisional; Region: PRK11663
99287011359	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287011360	putative substrate translocation pore; other site
99287011361	sensory histidine kinase UhpB; Provisional; Region: PRK11644
99287011362	MASE1; Region: MASE1; pfam05231
99287011363	Histidine kinase; Region: HisKA_3; pfam07730
99287011364	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287011365	ATP binding site [chemical binding]; other site
99287011366	Mg2+ binding site [ion binding]; other site
99287011367	G-X-G motif; other site
99287011368	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
99287011369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287011370	active site
99287011371	phosphorylation site [posttranslational modification]
99287011372	intermolecular recognition site; other site
99287011373	dimerization interface [polypeptide binding]; other site
99287011374	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287011375	DNA binding residues [nucleotide binding]
99287011376	dimerization interface [polypeptide binding]; other site
99287011377	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
99287011378	active site
99287011379	catalytic residues [active]
99287011380	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
99287011381	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287011382	putative substrate translocation pore; other site
99287011383	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
99287011384	substrate binding site [chemical binding]; other site
99287011385	dimer interface [polypeptide binding]; other site
99287011386	ATP binding site [chemical binding]; other site
99287011387	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
99287011388	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
99287011389	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287011390	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
99287011391	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
99287011392	putative valine binding site [chemical binding]; other site
99287011393	dimer interface [polypeptide binding]; other site
99287011394	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
99287011395	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
99287011396	PYR/PP interface [polypeptide binding]; other site
99287011397	dimer interface [polypeptide binding]; other site
99287011398	TPP binding site [chemical binding]; other site
99287011399	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
99287011400	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
99287011401	TPP-binding site [chemical binding]; other site
99287011402	dimer interface [polypeptide binding]; other site
99287011403	ilvB operon leader peptide; Provisional; Region: PRK10214
99287011404	ribosomal slippage
99287011405	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
99287011406	EamA-like transporter family; Region: EamA; pfam00892
99287011407	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
99287011408	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287011409	putative substrate translocation pore; other site
99287011410	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
99287011411	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
99287011412	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287011413	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
99287011414	dimerization interface [polypeptide binding]; other site
99287011415	substrate binding pocket [chemical binding]; other site
99287011416	permease DsdX; Provisional; Region: PRK09921
99287011417	GntP family permease; Region: GntP_permease; pfam02447
99287011418	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
99287011419	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
99287011420	catalytic residue [active]
99287011421	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
99287011422	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
99287011423	Domain of unknown function (DUF202); Region: DUF202; pfam02656
99287011424	Predicted membrane protein [Function unknown]; Region: COG2149
99287011425	putative transporter; Validated; Region: PRK03818
99287011426	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
99287011427	TrkA-C domain; Region: TrkA_C; pfam02080
99287011428	TrkA-C domain; Region: TrkA_C; pfam02080
99287011429	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
99287011430	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
99287011431	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
99287011432	putative dimer interface [polypeptide binding]; other site
99287011433	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
99287011434	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
99287011435	putative dimer interface [polypeptide binding]; other site
99287011436	hypothetical protein; Provisional; Region: PRK11616
99287011437	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
99287011438	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
99287011439	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
99287011440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287011441	binding surface
99287011442	TPR motif; other site
99287011443	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
99287011444	catalytic residues [active]
99287011445	central insert; other site
99287011446	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
99287011447	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
99287011448	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
99287011449	heme exporter protein CcmC; Region: ccmC; TIGR01191
99287011450	heme exporter protein CcmB; Region: ccmB; TIGR01190
99287011451	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
99287011452	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
99287011453	Walker A/P-loop; other site
99287011454	ATP binding site [chemical binding]; other site
99287011455	Q-loop/lid; other site
99287011456	ABC transporter signature motif; other site
99287011457	Walker B; other site
99287011458	D-loop; other site
99287011459	H-loop/switch region; other site
99287011460	Haem-binding domain; Region: Haem_bd; pfam14376
99287011461	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
99287011462	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
99287011463	chaperone protein TorD; Validated; Region: torD; PRK04976
99287011464	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
99287011465	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
99287011466	molybdopterin cofactor binding site [chemical binding]; other site
99287011467	substrate binding site [chemical binding]; other site
99287011468	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
99287011469	molybdopterin cofactor binding site; other site
99287011470	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
99287011471	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
99287011472	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
99287011473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287011474	active site
99287011475	phosphorylation site [posttranslational modification]
99287011476	intermolecular recognition site; other site
99287011477	dimerization interface [polypeptide binding]; other site
99287011478	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287011479	DNA binding site [nucleotide binding]
99287011480	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
99287011481	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
99287011482	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
99287011483	HAMP domain; Region: HAMP; pfam00672
99287011484	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287011485	dimer interface [polypeptide binding]; other site
99287011486	phosphorylation site [posttranslational modification]
99287011487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287011488	ATP binding site [chemical binding]; other site
99287011489	Mg2+ binding site [ion binding]; other site
99287011490	G-X-G motif; other site
99287011491	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287011492	active site
99287011493	phosphorylation site [posttranslational modification]
99287011494	intermolecular recognition site; other site
99287011495	dimerization interface [polypeptide binding]; other site
99287011496	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
99287011497	putative binding surface; other site
99287011498	active site
99287011499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287011500	D-galactonate transporter; Region: 2A0114; TIGR00893
99287011501	putative substrate translocation pore; other site
99287011502	galactonate dehydratase; Provisional; Region: PRK14017
99287011503	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
99287011504	putative active site pocket [active]
99287011505	putative metal binding site [ion binding]; other site
99287011506	similar to aldolase; contains frameshifts
99287011507	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
99287011508	Transcriptional regulators [Transcription]; Region: FadR; COG2186
99287011509	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287011510	DNA-binding site [nucleotide binding]; DNA binding site
99287011511	FCD domain; Region: FCD; pfam07729
99287011512	sugar phosphate phosphatase; Provisional; Region: PRK10513
99287011513	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287011514	active site
99287011515	motif I; other site
99287011516	motif II; other site
99287011517	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287011518	D-galactonate transporter; Region: 2A0114; TIGR00893
99287011519	putative substrate translocation pore; other site
99287011520	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
99287011521	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
99287011522	active site pocket [active]
99287011523	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287011524	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287011525	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
99287011526	putative dimerization interface [polypeptide binding]; other site
99287011527	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
99287011528	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287011529	ATP binding site [chemical binding]; other site
99287011530	Mg2+ binding site [ion binding]; other site
99287011531	G-X-G motif; other site
99287011532	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
99287011533	anchoring element; other site
99287011534	dimer interface [polypeptide binding]; other site
99287011535	ATP binding site [chemical binding]; other site
99287011536	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
99287011537	active site
99287011538	putative metal-binding site [ion binding]; other site
99287011539	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
99287011540	recF protein; Region: recf; TIGR00611
99287011541	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287011542	Walker A/P-loop; other site
99287011543	ATP binding site [chemical binding]; other site
99287011544	Q-loop/lid; other site
99287011545	ABC transporter signature motif; other site
99287011546	Walker B; other site
99287011547	D-loop; other site
99287011548	H-loop/switch region; other site
99287011549	DNA polymerase III subunit beta; Validated; Region: PRK05643
99287011550	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
99287011551	putative DNA binding surface [nucleotide binding]; other site
99287011552	dimer interface [polypeptide binding]; other site
99287011553	beta-clamp/clamp loader binding surface; other site
99287011554	beta-clamp/translesion DNA polymerase binding surface; other site
99287011555	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
99287011556	DnaA N-terminal domain; Region: DnaA_N; pfam11638
99287011557	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287011558	Walker A motif; other site
99287011559	ATP binding site [chemical binding]; other site
99287011560	Walker B motif; other site
99287011561	arginine finger; other site
99287011562	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
99287011563	DnaA box-binding interface [nucleotide binding]; other site
99287011564	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
99287011565	ribonuclease P; Reviewed; Region: rnpA; PRK01732
99287011566	hypothetical protein; Validated; Region: PRK00041
99287011567	membrane protein insertase; Provisional; Region: PRK01318
99287011568	YidC periplasmic domain; Region: YidC_periplas; pfam14849
99287011569	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
99287011570	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
99287011571	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
99287011572	trmE is a tRNA modification GTPase; Region: trmE; cd04164
99287011573	G1 box; other site
99287011574	GTP/Mg2+ binding site [chemical binding]; other site
99287011575	Switch I region; other site
99287011576	G2 box; other site
99287011577	Switch II region; other site
99287011578	G3 box; other site
99287011579	G4 box; other site
99287011580	G5 box; other site
99287011581	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
99287011582	putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331
99287011583	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
99287011584	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
99287011585	putative active site [active]
99287011586	putative NTP binding site [chemical binding]; other site
99287011587	putative nucleic acid binding site [nucleotide binding]; other site
99287011588	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
99287011589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287011590	putative substrate translocation pore; other site
99287011591	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
99287011592	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287011593	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
99287011594	substrate binding pocket [chemical binding]; other site
99287011595	dimerization interface [polypeptide binding]; other site
99287011596	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
99287011597	Predicted flavoprotein [General function prediction only]; Region: COG0431
99287011598	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
99287011599	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
99287011600	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287011601	active site
99287011602	motif I; other site
99287011603	motif II; other site
99287011604	transcriptional regulator PhoU; Provisional; Region: PRK11115
99287011605	PhoU domain; Region: PhoU; pfam01895
99287011606	PhoU domain; Region: PhoU; pfam01895
99287011607	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
99287011608	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
99287011609	Walker A/P-loop; other site
99287011610	ATP binding site [chemical binding]; other site
99287011611	Q-loop/lid; other site
99287011612	ABC transporter signature motif; other site
99287011613	Walker B; other site
99287011614	D-loop; other site
99287011615	H-loop/switch region; other site
99287011616	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
99287011617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287011618	dimer interface [polypeptide binding]; other site
99287011619	conserved gate region; other site
99287011620	putative PBP binding loops; other site
99287011621	ABC-ATPase subunit interface; other site
99287011622	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
99287011623	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287011624	dimer interface [polypeptide binding]; other site
99287011625	conserved gate region; other site
99287011626	putative PBP binding loops; other site
99287011627	ABC-ATPase subunit interface; other site
99287011628	phosphate ABC transporter periplasmic substrate-binding protein PstS; Provisional; Region: PRK10918
99287011629	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287011630	substrate binding pocket [chemical binding]; other site
99287011631	membrane-bound complex binding site; other site
99287011632	hinge residues; other site
99287011633	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
99287011634	active site
99287011635	P-loop; other site
99287011636	phosphorylation site [posttranslational modification]
99287011637	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
99287011638	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
99287011639	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
99287011640	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
99287011641	shikimate binding site; other site
99287011642	NAD(P) binding site [chemical binding]; other site
99287011643	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
99287011644	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
99287011645	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
99287011646	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
99287011647	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
99287011648	glutaminase active site [active]
99287011649	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
99287011650	dimer interface [polypeptide binding]; other site
99287011651	active site
99287011652	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
99287011653	dimer interface [polypeptide binding]; other site
99287011654	active site
99287011655	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
99287011656	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
99287011657	Substrate binding site; other site
99287011658	Mg++ binding site; other site
99287011659	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
99287011660	active site
99287011661	substrate binding site [chemical binding]; other site
99287011662	CoA binding site [chemical binding]; other site
99287011663	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
99287011664	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
99287011665	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
99287011666	gamma subunit interface [polypeptide binding]; other site
99287011667	epsilon subunit interface [polypeptide binding]; other site
99287011668	LBP interface [polypeptide binding]; other site
99287011669	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
99287011670	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
99287011671	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
99287011672	alpha subunit interaction interface [polypeptide binding]; other site
99287011673	Walker A motif; other site
99287011674	ATP binding site [chemical binding]; other site
99287011675	Walker B motif; other site
99287011676	inhibitor binding site; inhibition site
99287011677	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
99287011678	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
99287011679	core domain interface [polypeptide binding]; other site
99287011680	delta subunit interface [polypeptide binding]; other site
99287011681	epsilon subunit interface [polypeptide binding]; other site
99287011682	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
99287011683	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
99287011684	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
99287011685	beta subunit interaction interface [polypeptide binding]; other site
99287011686	Walker A motif; other site
99287011687	ATP binding site [chemical binding]; other site
99287011688	Walker B motif; other site
99287011689	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
99287011690	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
99287011691	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
99287011692	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
99287011693	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
99287011694	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
99287011695	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
99287011696	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
99287011697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287011698	S-adenosylmethionine binding site [chemical binding]; other site
99287011699	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
99287011700	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
99287011701	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
99287011702	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
99287011703	FMN-binding protein MioC; Provisional; Region: PRK09004
99287011704	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
99287011705	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99287011706	putative DNA binding site [nucleotide binding]; other site
99287011707	putative Zn2+ binding site [ion binding]; other site
99287011708	AsnC family; Region: AsnC_trans_reg; pfam01037
99287011709	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
99287011710	dimer interface [polypeptide binding]; other site
99287011711	active site
99287011712	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425
99287011713	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
99287011714	metal ion-dependent adhesion site (MIDAS); other site
99287011715	regulatory ATPase RavA; Provisional; Region: PRK13531
99287011716	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287011717	Walker A motif; other site
99287011718	ATP binding site [chemical binding]; other site
99287011719	Walker B motif; other site
99287011720	arginine finger; other site
99287011721	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
99287011722	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
99287011723	D-ribose pyranase; Provisional; Region: PRK11797
99287011724	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
99287011725	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
99287011726	Walker A/P-loop; other site
99287011727	ATP binding site [chemical binding]; other site
99287011728	Q-loop/lid; other site
99287011729	ABC transporter signature motif; other site
99287011730	Walker B; other site
99287011731	D-loop; other site
99287011732	H-loop/switch region; other site
99287011733	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
99287011734	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
99287011735	TM-ABC transporter signature motif; other site
99287011736	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
99287011737	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
99287011738	ligand binding site [chemical binding]; other site
99287011739	dimerization interface [polypeptide binding]; other site
99287011740	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
99287011741	substrate binding site [chemical binding]; other site
99287011742	dimer interface [polypeptide binding]; other site
99287011743	ATP binding site [chemical binding]; other site
99287011744	transcriptional repressor RbsR; Provisional; Region: PRK10423
99287011745	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287011746	DNA binding site [nucleotide binding]
99287011747	domain linker motif; other site
99287011748	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
99287011749	dimerization interface [polypeptide binding]; other site
99287011750	ligand binding site [chemical binding]; other site
99287011751	putative transporter; Provisional; Region: PRK10504
99287011752	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287011753	putative substrate translocation pore; other site
99287011754	Transcriptional regulators [Transcription]; Region: FadR; COG2186
99287011755	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287011756	DNA-binding site [nucleotide binding]; DNA binding site
99287011757	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
99287011758	transcriptional regulator HdfR; Provisional; Region: PRK03601
99287011759	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287011760	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
99287011761	dimerization interface [polypeptide binding]; other site
99287011762	hypothetical protein; Provisional; Region: PRK11027
99287011763	putative ATP-dependent protease; Provisional; Region: PRK09862
99287011764	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
99287011765	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287011766	Walker A motif; other site
99287011767	ATP binding site [chemical binding]; other site
99287011768	Walker B motif; other site
99287011769	arginine finger; other site
99287011770	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
99287011771	ilvG operon leader peptide; Provisional; Region: PRK10424
99287011772	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
99287011773	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
99287011774	PYR/PP interface [polypeptide binding]; other site
99287011775	dimer interface [polypeptide binding]; other site
99287011776	TPP binding site [chemical binding]; other site
99287011777	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
99287011778	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
99287011779	TPP-binding site [chemical binding]; other site
99287011780	dimer interface [polypeptide binding]; other site
99287011781	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
99287011782	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
99287011783	homodimer interface [polypeptide binding]; other site
99287011784	substrate-cofactor binding pocket; other site
99287011785	catalytic residue [active]
99287011786	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
99287011787	threonine dehydratase; Reviewed; Region: PRK09224
99287011788	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
99287011789	tetramer interface [polypeptide binding]; other site
99287011790	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287011791	catalytic residue [active]
99287011792	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
99287011793	putative Ile/Val binding site [chemical binding]; other site
99287011794	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
99287011795	putative Ile/Val binding site [chemical binding]; other site
99287011796	Phage-related protein [Function unknown]; Region: COG4679
99287011797	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
99287011798	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287011799	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
99287011800	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
99287011801	putative dimerization interface [polypeptide binding]; other site
99287011802	ketol-acid reductoisomerase; Validated; Region: PRK05225
99287011803	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
99287011804	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
99287011805	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
99287011806	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
99287011807	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
99287011808	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
99287011809	Part of AAA domain; Region: AAA_19; pfam13245
99287011810	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
99287011811	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
99287011812	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
99287011813	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
99287011814	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
99287011815	ATP binding site [chemical binding]; other site
99287011816	Mg++ binding site [ion binding]; other site
99287011817	motif III; other site
99287011818	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287011819	nucleotide binding region [chemical binding]; other site
99287011820	ATP-binding site [chemical binding]; other site
99287011821	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
99287011822	catalytic residues [active]
99287011823	transcription termination factor Rho; Provisional; Region: rho; PRK09376
99287011824	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
99287011825	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
99287011826	RNA binding site [nucleotide binding]; other site
99287011827	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
99287011828	multimer interface [polypeptide binding]; other site
99287011829	Walker A motif; other site
99287011830	ATP binding site [chemical binding]; other site
99287011831	Walker B motif; other site
99287011832	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
99287011833	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
99287011834	Mg++ binding site [ion binding]; other site
99287011835	putative catalytic motif [active]
99287011836	substrate binding site [chemical binding]; other site
99287011837	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
99287011838	Chain length determinant protein; Region: Wzz; pfam02706
99287011839	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
99287011840	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
99287011841	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
99287011842	active site
99287011843	homodimer interface [polypeptide binding]; other site
99287011844	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
99287011845	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
99287011846	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
99287011847	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
99287011848	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
99287011849	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
99287011850	NAD binding site [chemical binding]; other site
99287011851	substrate binding site [chemical binding]; other site
99287011852	homodimer interface [polypeptide binding]; other site
99287011853	active site
99287011854	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
99287011855	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
99287011856	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
99287011857	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
99287011858	inhibitor-cofactor binding pocket; inhibition site
99287011859	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287011860	catalytic residue [active]
99287011861	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
99287011862	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
99287011863	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
99287011864	putative common antigen polymerase; Provisional; Region: PRK02975
99287011865	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
99287011866	putative transport protein YifK; Provisional; Region: PRK10746
99287011867	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
99287011868	HemY protein N-terminus; Region: HemY_N; pfam07219
99287011869	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287011870	binding surface
99287011871	TPR motif; other site
99287011872	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
99287011873	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
99287011874	active site
99287011875	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
99287011876	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
99287011877	domain interfaces; other site
99287011878	active site
99287011879	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
99287011880	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
99287011881	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
99287011882	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
99287011883	putative iron binding site [ion binding]; other site
99287011884	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
99287011885	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
99287011886	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
99287011887	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
99287011888	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
99287011889	hypothetical protein; Provisional; Region: PRK10963
99287011890	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
99287011891	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
99287011892	active site
99287011893	Int/Topo IB signature motif; other site
99287011894	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
99287011895	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
99287011896	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287011897	motif II; other site
99287011898	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
99287011899	Part of AAA domain; Region: AAA_19; pfam13245
99287011900	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
99287011901	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
99287011902	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
99287011903	Cl binding site [ion binding]; other site
99287011904	oligomer interface [polypeptide binding]; other site
99287011905	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
99287011906	hypothetical protein; Provisional; Region: PRK11371
99287011907	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
99287011908	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
99287011909	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
99287011910	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
99287011911	CoenzymeA binding site [chemical binding]; other site
99287011912	subunit interaction site [polypeptide binding]; other site
99287011913	PHB binding site; other site
99287011914	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
99287011915	dimerization interface [polypeptide binding]; other site
99287011916	substrate binding site [chemical binding]; other site
99287011917	active site
99287011918	calcium binding site [ion binding]; other site
99287011919	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
99287011920	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99287011921	ATP binding site [chemical binding]; other site
99287011922	putative Mg++ binding site [ion binding]; other site
99287011923	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
99287011924	nucleotide binding region [chemical binding]; other site
99287011925	ATP-binding site [chemical binding]; other site
99287011926	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
99287011927	HRDC domain; Region: HRDC; pfam00570
99287011928	threonine efflux system; Provisional; Region: PRK10229
99287011929	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
99287011930	lysophospholipase L2; Provisional; Region: PRK10749
99287011931	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
99287011932	putative hydrolase; Provisional; Region: PRK10976
99287011933	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287011934	active site
99287011935	motif I; other site
99287011936	motif II; other site
99287011937	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
99287011938	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
99287011939	EamA-like transporter family; Region: EamA; pfam00892
99287011940	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
99287011941	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287011942	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
99287011943	putative dimerization interface [polypeptide binding]; other site
99287011944	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
99287011945	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
99287011946	THF binding site; other site
99287011947	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
99287011948	substrate binding site [chemical binding]; other site
99287011949	THF binding site; other site
99287011950	zinc-binding site [ion binding]; other site
99287011951	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
99287011952	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287011953	FeS/SAM binding site; other site
99287011954	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
99287011955	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
99287011956	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
99287011957	uridine phosphorylase; Provisional; Region: PRK11178
99287011958	DNA recombination protein RmuC; Provisional; Region: PRK10361
99287011959	RmuC family; Region: RmuC; pfam02646
99287011960	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
99287011961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287011962	S-adenosylmethionine binding site [chemical binding]; other site
99287011963	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
99287011964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
99287011965	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
99287011966	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
99287011967	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
99287011968	sec-independent translocase; Provisional; Region: PRK01770
99287011969	sec-independent translocase; Provisional; Region: tatB; PRK00404
99287011970	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
99287011971	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
99287011972	active site
99287011973	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
99287011974	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
99287011975	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
99287011976	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
99287011977	FMN reductase; Validated; Region: fre; PRK08051
99287011978	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
99287011979	FAD binding pocket [chemical binding]; other site
99287011980	FAD binding motif [chemical binding]; other site
99287011981	phosphate binding motif [ion binding]; other site
99287011982	beta-alpha-beta structure motif; other site
99287011983	NAD binding pocket [chemical binding]; other site
99287011984	Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972
99287011985	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
99287011986	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
99287011987	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
99287011988	dimer interface [polypeptide binding]; other site
99287011989	active site
99287011990	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
99287011991	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
99287011992	substrate binding site [chemical binding]; other site
99287011993	oxyanion hole (OAH) forming residues; other site
99287011994	trimer interface [polypeptide binding]; other site
99287011995	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
99287011996	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
99287011997	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
99287011998	proline dipeptidase; Provisional; Region: PRK13607
99287011999	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
99287012000	active site
99287012001	hypothetical protein; Provisional; Region: PRK11568
99287012002	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
99287012003	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
99287012004	potassium transporter; Provisional; Region: PRK10750
99287012005	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
99287012006	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
99287012007	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
99287012008	Walker A motif; other site
99287012009	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
99287012010	GTP binding site; other site
99287012011	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
99287012012	serine/threonine protein kinase; Provisional; Region: PRK11768
99287012013	Phosphotransferase enzyme family; Region: APH; pfam01636
99287012014	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
99287012015	catalytic residues [active]
99287012016	hinge region; other site
99287012017	alpha helical domain; other site
99287012018	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
99287012019	putative acyl-acceptor binding pocket; other site
99287012020	DNA polymerase I; Provisional; Region: PRK05755
99287012021	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
99287012022	active site
99287012023	metal binding site 1 [ion binding]; metal-binding site
99287012024	putative 5' ssDNA interaction site; other site
99287012025	metal binding site 3; metal-binding site
99287012026	metal binding site 2 [ion binding]; metal-binding site
99287012027	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
99287012028	putative DNA binding site [nucleotide binding]; other site
99287012029	putative metal binding site [ion binding]; other site
99287012030	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
99287012031	active site
99287012032	catalytic site [active]
99287012033	substrate binding site [chemical binding]; other site
99287012034	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
99287012035	active site
99287012036	DNA binding site [nucleotide binding]
99287012037	catalytic site [active]
99287012038	Predicted GTPase [General function prediction only]; Region: COG0218
99287012039	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
99287012040	G1 box; other site
99287012041	GTP/Mg2+ binding site [chemical binding]; other site
99287012042	Switch I region; other site
99287012043	G2 box; other site
99287012044	G3 box; other site
99287012045	Switch II region; other site
99287012046	G4 box; other site
99287012047	G5 box; other site
99287012048	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
99287012049	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
99287012050	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
99287012051	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287012052	FeS/SAM binding site; other site
99287012053	HemN C-terminal domain; Region: HemN_C; pfam06969
99287012054	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
99287012055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287012056	active site
99287012057	phosphorylation site [posttranslational modification]
99287012058	intermolecular recognition site; other site
99287012059	dimerization interface [polypeptide binding]; other site
99287012060	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287012061	Walker A motif; other site
99287012062	ATP binding site [chemical binding]; other site
99287012063	Walker B motif; other site
99287012064	arginine finger; other site
99287012065	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
99287012066	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
99287012067	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
99287012068	putative active site [active]
99287012069	heme pocket [chemical binding]; other site
99287012070	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287012071	dimer interface [polypeptide binding]; other site
99287012072	phosphorylation site [posttranslational modification]
99287012073	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287012074	ATP binding site [chemical binding]; other site
99287012075	Mg2+ binding site [ion binding]; other site
99287012076	G-X-G motif; other site
99287012077	glutamine synthetase; Provisional; Region: glnA; PRK09469
99287012078	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
99287012079	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
99287012080	GTP-binding protein; Provisional; Region: PRK10218
99287012081	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
99287012082	G1 box; other site
99287012083	putative GEF interaction site [polypeptide binding]; other site
99287012084	GTP/Mg2+ binding site [chemical binding]; other site
99287012085	Switch I region; other site
99287012086	G2 box; other site
99287012087	G3 box; other site
99287012088	Switch II region; other site
99287012089	G4 box; other site
99287012090	G5 box; other site
99287012091	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
99287012092	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
99287012093	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
99287012094	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287012095	active site
99287012096	motif I; other site
99287012097	motif II; other site
99287012098	Radical SAM superfamily; Region: Radical_SAM; pfam04055
99287012099	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287012100	FeS/SAM binding site; other site
99287012101	coproporphyrinogen III oxidase; Validated; Region: PRK08208
99287012102	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287012103	FeS/SAM binding site; other site
99287012104	HemN C-terminal domain; Region: HemN_C; pfam06969
99287012105	Sulfatase; Region: Sulfatase; cl19157
99287012106	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
99287012107	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116
99287012108	Leucine-rich repeats; other site
99287012109	Substrate binding site [chemical binding]; other site
99287012110	outer membrane porin L; Provisional; Region: ompL; PRK09980
99287012111	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
99287012112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287012113	putative substrate translocation pore; other site
99287012114	putative symporter YagG; Provisional; Region: PRK09669; cl15392
99287012115	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
99287012116	alpha-glucosidase; Provisional; Region: PRK10426
99287012117	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
99287012118	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
99287012119	putative active site [active]
99287012120	putative catalytic site [active]
99287012121	putative aldose-1-epimerase; Provisional; Region: PRK15172
99287012122	active site
99287012123	catalytic residues [active]
99287012124	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
99287012125	dimerization interface [polypeptide binding]; other site
99287012126	putative active cleft [active]
99287012127	Class I aldolases; Region: Aldolase_Class_I; cd00945
99287012128	catalytic residue [active]
99287012129	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
99287012130	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
99287012131	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
99287012132	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
99287012133	substrate binding site [chemical binding]; other site
99287012134	ATP binding site [chemical binding]; other site
99287012135	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
99287012136	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
99287012137	putative DNA binding site [nucleotide binding]; other site
99287012138	putative Zn2+ binding site [ion binding]; other site
99287012139	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287012140	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
99287012141	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287012142	motif II; other site
99287012143	hypothetical protein; Reviewed; Region: PRK01637
99287012144	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
99287012145	putative active site [active]
99287012146	dimerization interface [polypeptide binding]; other site
99287012147	putative tRNAtyr binding site [nucleotide binding]; other site
99287012148	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287012149	Coenzyme A binding pocket [chemical binding]; other site
99287012150	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
99287012151	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
99287012152	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
99287012153	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287012154	non-specific DNA binding site [nucleotide binding]; other site
99287012155	salt bridge; other site
99287012156	sequence-specific DNA binding site [nucleotide binding]; other site
99287012157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
99287012158	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
99287012159	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
99287012160	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
99287012161	Predicted transcriptional regulator [Transcription]; Region: COG2944
99287012162	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287012163	non-specific DNA binding site [nucleotide binding]; other site
99287012164	salt bridge; other site
99287012165	sequence-specific DNA binding site [nucleotide binding]; other site
99287012166	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
99287012167	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
99287012168	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
99287012169	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287012170	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
99287012171	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
99287012172	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
99287012173	[4Fe-4S] binding site [ion binding]; other site
99287012174	molybdopterin cofactor binding site; other site
99287012175	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
99287012176	molybdopterin cofactor binding site; other site
99287012177	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
99287012178	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
99287012179	Predicted coiled-coil domain-containing protein (DUF2360); Region: DUF2360; pfam10152
99287012180	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
99287012181	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
99287012182	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
99287012183	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
99287012184	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287012185	non-specific DNA binding site [nucleotide binding]; other site
99287012186	salt bridge; other site
99287012187	sequence-specific DNA binding site [nucleotide binding]; other site
99287012188	Cupin domain; Region: Cupin_2; cl17218
99287012189	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
99287012190	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
99287012191	dimer interface [polypeptide binding]; other site
99287012192	active site
99287012193	metal binding site [ion binding]; metal-binding site
99287012194	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
99287012195	intersubunit interface [polypeptide binding]; other site
99287012196	active site
99287012197	Zn2+ binding site [ion binding]; other site
99287012198	L-rhamnose isomerase; Provisional; Region: PRK01076
99287012199	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
99287012200	N- and C-terminal domain interface [polypeptide binding]; other site
99287012201	active site
99287012202	putative catalytic site [active]
99287012203	metal binding site [ion binding]; metal-binding site
99287012204	ATP binding site [chemical binding]; other site
99287012205	rhamnulokinase; Provisional; Region: rhaB; PRK10640
99287012206	carbohydrate binding site [chemical binding]; other site
99287012207	transcriptional activator RhaS; Provisional; Region: PRK13503
99287012208	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
99287012209	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287012210	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287012211	transcriptional activator RhaR; Provisional; Region: PRK13502
99287012212	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
99287012213	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287012214	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287012215	L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379
99287012216	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
99287012217	DctM-like transporters; Region: DctM; pfam06808
99287012218	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
99287012219	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
99287012220	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
99287012221	superoxide dismutase; Provisional; Region: PRK10925
99287012222	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
99287012223	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
99287012224	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
99287012225	MOSC domain; Region: MOSC; pfam03473
99287012226	3-alpha domain; Region: 3-alpha; pfam03475
99287012227	SnoaL-like domain; Region: SnoaL_2; pfam12680
99287012228	two-component sensor protein; Provisional; Region: cpxA; PRK09470
99287012229	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287012230	dimerization interface [polypeptide binding]; other site
99287012231	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287012232	dimer interface [polypeptide binding]; other site
99287012233	phosphorylation site [posttranslational modification]
99287012234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287012235	ATP binding site [chemical binding]; other site
99287012236	Mg2+ binding site [ion binding]; other site
99287012237	G-X-G motif; other site
99287012238	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
99287012239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287012240	active site
99287012241	intermolecular recognition site; other site
99287012242	dimerization interface [polypeptide binding]; other site
99287012243	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287012244	DNA binding site [nucleotide binding]
99287012245	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
99287012246	dimer interface [polypeptide binding]; other site
99287012247	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
99287012248	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
99287012249	active site
99287012250	ADP/pyrophosphate binding site [chemical binding]; other site
99287012251	dimerization interface [polypeptide binding]; other site
99287012252	allosteric effector site; other site
99287012253	fructose-1,6-bisphosphate binding site; other site
99287012254	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287012255	substrate binding pocket [chemical binding]; other site
99287012256	membrane-bound complex binding site; other site
99287012257	hinge residues; other site
99287012258	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
99287012259	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
99287012260	putative symporter YagG; Provisional; Region: PRK09669; cl15392
99287012261	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
99287012262	putative substrate binding site [chemical binding]; other site
99287012263	putative ATP binding site [chemical binding]; other site
99287012264	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
99287012265	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
99287012266	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287012267	DNA-binding site [nucleotide binding]; DNA binding site
99287012268	Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293
99287012269	UTRA domain; Region: UTRA; pfam07702
99287012270	CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934
99287012271	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
99287012272	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
99287012273	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
99287012274	putative N- and C-terminal domain interface [polypeptide binding]; other site
99287012275	putative active site [active]
99287012276	putative MgATP binding site [chemical binding]; other site
99287012277	catalytic site [active]
99287012278	metal binding site [ion binding]; metal-binding site
99287012279	putative carbohydrate binding site [chemical binding]; other site
99287012280	transcriptional regulator LsrR; Provisional; Region: PRK15418
99287012281	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
99287012282	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
99287012283	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
99287012284	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
99287012285	Walker A/P-loop; other site
99287012286	ATP binding site [chemical binding]; other site
99287012287	Q-loop/lid; other site
99287012288	ABC transporter signature motif; other site
99287012289	Walker B; other site
99287012290	D-loop; other site
99287012291	H-loop/switch region; other site
99287012292	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
99287012293	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
99287012294	TM-ABC transporter signature motif; other site
99287012295	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
99287012296	TM-ABC transporter signature motif; other site
99287012297	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
99287012298	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
99287012299	ligand binding site [chemical binding]; other site
99287012300	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
99287012301	putative active site; other site
99287012302	catalytic residue [active]
99287012303	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
99287012304	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
99287012305	substrate binding site [chemical binding]; other site
99287012306	hexamer interface [polypeptide binding]; other site
99287012307	metal binding site [ion binding]; metal-binding site
99287012308	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
99287012309	substrate binding site [chemical binding]; other site
99287012310	dimer interface [polypeptide binding]; other site
99287012311	catalytic triad [active]
99287012312	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
99287012313	Predicted membrane protein [Function unknown]; Region: COG3152
99287012314	ferredoxin-NADP reductase; Provisional; Region: PRK10926
99287012315	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
99287012316	FAD binding pocket [chemical binding]; other site
99287012317	FAD binding motif [chemical binding]; other site
99287012318	phosphate binding motif [ion binding]; other site
99287012319	beta-alpha-beta structure motif; other site
99287012320	NAD binding pocket [chemical binding]; other site
99287012321	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
99287012322	putative active site [active]
99287012323	glycerol kinase; Provisional; Region: glpK; PRK00047
99287012324	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
99287012325	N- and C-terminal domain interface [polypeptide binding]; other site
99287012326	active site
99287012327	MgATP binding site [chemical binding]; other site
99287012328	catalytic site [active]
99287012329	metal binding site [ion binding]; metal-binding site
99287012330	glycerol binding site [chemical binding]; other site
99287012331	homotetramer interface [polypeptide binding]; other site
99287012332	homodimer interface [polypeptide binding]; other site
99287012333	FBP binding site [chemical binding]; other site
99287012334	protein IIAGlc interface [polypeptide binding]; other site
99287012335	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
99287012336	amphipathic channel; other site
99287012337	Asn-Pro-Ala signature motifs; other site
99287012338	septal ring assembly protein ZapB; Provisional; Region: PRK15422
99287012339	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
99287012340	1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962
99287012341	putative active site [active]
99287012342	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
99287012343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287012344	Walker A motif; other site
99287012345	ATP binding site [chemical binding]; other site
99287012346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287012347	Walker B motif; other site
99287012348	arginine finger; other site
99287012349	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
99287012350	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
99287012351	active site
99287012352	HslU subunit interaction site [polypeptide binding]; other site
99287012353	essential cell division protein FtsN; Provisional; Region: PRK10927
99287012354	Sporulation related domain; Region: SPOR; pfam05036
99287012355	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287012356	DNA binding site [nucleotide binding]
99287012357	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
99287012358	domain linker motif; other site
99287012359	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
99287012360	dimerization interface [polypeptide binding]; other site
99287012361	ligand binding site [chemical binding]; other site
99287012362	primosome assembly protein PriA; Validated; Region: PRK05580
99287012363	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99287012364	ATP binding site [chemical binding]; other site
99287012365	putative Mg++ binding site [ion binding]; other site
99287012366	helicase superfamily c-terminal domain; Region: HELICc; smart00490
99287012367	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
99287012368	conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117
99287012369	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
99287012370	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
99287012371	dimerization interface [polypeptide binding]; other site
99287012372	DNA binding site [nucleotide binding]
99287012373	corepressor binding sites; other site
99287012374	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
99287012375	homodimer interface [polypeptide binding]; other site
99287012376	substrate-cofactor binding pocket; other site
99287012377	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287012378	catalytic residue [active]
99287012379	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
99287012380	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
99287012381	putative catalytic residues [active]
99287012382	putative nucleotide binding site [chemical binding]; other site
99287012383	putative aspartate binding site [chemical binding]; other site
99287012384	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
99287012385	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
99287012386	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
99287012387	mechanosensitive channel MscS; Provisional; Region: PRK10334
99287012388	Conserved TM helix; Region: TM_helix; pfam05552
99287012389	Mechanosensitive ion channel; Region: MS_channel; pfam00924
99287012390	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
99287012391	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
99287012392	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
99287012393	active site
99287012394	metal binding site [ion binding]; metal-binding site
99287012395	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
99287012396	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
99287012397	FAD binding site [chemical binding]; other site
99287012398	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
99287012399	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
99287012400	heme binding site [chemical binding]; other site
99287012401	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
99287012402	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738
99287012403	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
99287012404	dimer interface [polypeptide binding]; other site
99287012405	active site
99287012406	metal binding site [ion binding]; metal-binding site
99287012407	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
99287012408	active site
99287012409	intersubunit interactions; other site
99287012410	catalytic residue [active]
99287012411	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
99287012412	dimerization domain swap beta strand [polypeptide binding]; other site
99287012413	regulatory protein interface [polypeptide binding]; other site
99287012414	active site
99287012415	regulatory phosphorylation site [posttranslational modification]; other site
99287012416	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
99287012417	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
99287012418	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
99287012419	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
99287012420	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
99287012421	active site
99287012422	phosphorylation site [posttranslational modification]
99287012423	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
99287012424	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
99287012425	active site
99287012426	P-loop; other site
99287012427	phosphorylation site [posttranslational modification]
99287012428	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
99287012429	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
99287012430	dimer interface [polypeptide binding]; other site
99287012431	active site
99287012432	glycine loop; other site
99287012433	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
99287012434	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287012435	FeS/SAM binding site; other site
99287012436	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
99287012437	active site
99287012438	P-loop; other site
99287012439	phosphorylation site [posttranslational modification]
99287012440	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287012441	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99287012442	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287012443	hypothetical protein; Provisional; Region: PRK10649
99287012444	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
99287012445	Sulfatase; Region: Sulfatase; pfam00884
99287012446	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
99287012447	acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892
99287012448	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
99287012449	metal binding site [ion binding]; metal-binding site
99287012450	putative dimer interface [polypeptide binding]; other site
99287012451	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
99287012452	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
99287012453	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
99287012454	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
99287012455	nucleotide binding site [chemical binding]; other site
99287012456	N-acetyl-L-glutamate binding site [chemical binding]; other site
99287012457	argininosuccinate lyase; Provisional; Region: PRK04833
99287012458	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
99287012459	active sites [active]
99287012460	tetramer interface [polypeptide binding]; other site
99287012461	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
99287012462	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287012463	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
99287012464	dimerization interface [polypeptide binding]; other site
99287012465	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
99287012466	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
99287012467	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
99287012468	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
99287012469	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
99287012470	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287012471	hypothetical protein; Provisional; Region: PRK11056
99287012472	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
99287012473	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
99287012474	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287012475	S-adenosylmethionine binding site [chemical binding]; other site
99287012476	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
99287012477	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
99287012478	N-terminal plug; other site
99287012479	ligand-binding site [chemical binding]; other site
99287012480	glutamate racemase; Provisional; Region: PRK00865
99287012481	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
99287012482	FAD binding domain; Region: FAD_binding_4; pfam01565
99287012483	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
99287012484	Biotin operon repressor [Transcription]; Region: BirA; COG1654
99287012485	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
99287012486	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
99287012487	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
99287012488	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
99287012489	ATP-binding site [chemical binding]; other site
99287012490	CoA-binding site [chemical binding]; other site
99287012491	Mg2+-binding site [ion binding]; other site
99287012492	elongation factor Tu; Reviewed; Region: PRK00049
99287012493	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
99287012494	G1 box; other site
99287012495	GEF interaction site [polypeptide binding]; other site
99287012496	GTP/Mg2+ binding site [chemical binding]; other site
99287012497	Switch I region; other site
99287012498	G2 box; other site
99287012499	G3 box; other site
99287012500	Switch II region; other site
99287012501	G4 box; other site
99287012502	G5 box; other site
99287012503	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
99287012504	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
99287012505	Antibiotic Binding Site [chemical binding]; other site
99287012506	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
99287012507	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
99287012508	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
99287012509	putative homodimer interface [polypeptide binding]; other site
99287012510	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
99287012511	heterodimer interface [polypeptide binding]; other site
99287012512	homodimer interface [polypeptide binding]; other site
99287012513	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
99287012514	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
99287012515	23S rRNA interface [nucleotide binding]; other site
99287012516	L7/L12 interface [polypeptide binding]; other site
99287012517	putative thiostrepton binding site; other site
99287012518	L25 interface [polypeptide binding]; other site
99287012519	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
99287012520	mRNA/rRNA interface [nucleotide binding]; other site
99287012521	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
99287012522	23S rRNA interface [nucleotide binding]; other site
99287012523	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
99287012524	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
99287012525	core dimer interface [polypeptide binding]; other site
99287012526	peripheral dimer interface [polypeptide binding]; other site
99287012527	L10 interface [polypeptide binding]; other site
99287012528	L11 interface [polypeptide binding]; other site
99287012529	putative EF-Tu interaction site [polypeptide binding]; other site
99287012530	putative EF-G interaction site [polypeptide binding]; other site
99287012531	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
99287012532	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
99287012533	RPB12 interaction site [polypeptide binding]; other site
99287012534	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478
99287012535	RPB1 interaction site [polypeptide binding]; other site
99287012536	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
99287012537	RPB10 interaction site [polypeptide binding]; other site
99287012538	RPB11 interaction site [polypeptide binding]; other site
99287012539	RPB3 interaction site [polypeptide binding]; other site
99287012540	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
99287012541	beta and beta' interface [polypeptide binding]; other site
99287012542	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
99287012543	beta' and sigma factor interface [polypeptide binding]; other site
99287012544	Zn-binding [ion binding]; other site
99287012545	active site region [active]
99287012546	catalytic site [active]
99287012547	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
99287012548	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
99287012549	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
99287012550	G-loop; other site
99287012551	DNA binding site [nucleotide binding]
99287012552	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
99287012553	type III secretion system protein; Provisional; Region: PRK15384
99287012554	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
99287012555	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287012556	FeS/SAM binding site; other site
99287012557	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
99287012558	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
99287012559	ThiS interaction site; other site
99287012560	putative active site [active]
99287012561	tetramer interface [polypeptide binding]; other site
99287012562	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
99287012563	thiS-thiF/thiG interaction site; other site
99287012564	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
99287012565	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
99287012566	ATP binding site [chemical binding]; other site
99287012567	substrate interface [chemical binding]; other site
99287012568	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
99287012569	thiamine phosphate binding site [chemical binding]; other site
99287012570	active site
99287012571	pyrophosphate binding site [ion binding]; other site
99287012572	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
99287012573	ThiC-associated domain; Region: ThiC-associated; pfam13667
99287012574	ThiC family; Region: ThiC; pfam01964
99287012575	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
99287012576	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
99287012577	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
99287012578	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
99287012579	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
99287012580	putative NADH binding site [chemical binding]; other site
99287012581	putative active site [active]
99287012582	nudix motif; other site
99287012583	putative metal binding site [ion binding]; other site
99287012584	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
99287012585	substrate binding site [chemical binding]; other site
99287012586	active site
99287012587	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
99287012588	Active_site [active]
99287012589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
99287012590	histone-like DNA-binding protein HU; Region: HU; cd13831
99287012591	dimer interface [polypeptide binding]; other site
99287012592	DNA binding site [nucleotide binding]
99287012593	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
99287012594	zinc resistance protein; Provisional; Region: zraP; PRK11546
99287012595	dimer interface [polypeptide binding]; other site
99287012596	sensor protein ZraS; Provisional; Region: PRK10364
99287012597	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
99287012598	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287012599	dimer interface [polypeptide binding]; other site
99287012600	phosphorylation site [posttranslational modification]
99287012601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287012602	ATP binding site [chemical binding]; other site
99287012603	Mg2+ binding site [ion binding]; other site
99287012604	G-X-G motif; other site
99287012605	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
99287012606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287012607	active site
99287012608	phosphorylation site [posttranslational modification]
99287012609	intermolecular recognition site; other site
99287012610	dimerization interface [polypeptide binding]; other site
99287012611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287012612	Walker A motif; other site
99287012613	ATP binding site [chemical binding]; other site
99287012614	Walker B motif; other site
99287012615	arginine finger; other site
99287012616	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
99287012617	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
99287012618	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
99287012619	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
99287012620	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
99287012621	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
99287012622	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
99287012623	purine monophosphate binding site [chemical binding]; other site
99287012624	dimer interface [polypeptide binding]; other site
99287012625	putative catalytic residues [active]
99287012626	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
99287012627	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
99287012628	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287012629	Coenzyme A binding pocket [chemical binding]; other site
99287012630	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
99287012631	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
99287012632	proposed active site lysine [active]
99287012633	conserved cys residue [active]
99287012634	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
99287012635	active site
99287012636	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
99287012637	tetramer interface [polypeptide binding]; other site
99287012638	active site
99287012639	Mg2+/Mn2+ binding site [ion binding]; other site
99287012640	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
99287012641	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
99287012642	transcriptional repressor IclR; Provisional; Region: PRK11569
99287012643	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
99287012644	Bacterial transcriptional regulator; Region: IclR; pfam01614
99287012645	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
99287012646	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
99287012647	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
99287012648	substrate binding pocket [chemical binding]; other site
99287012649	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
99287012650	B12 binding site [chemical binding]; other site
99287012651	cobalt ligand [ion binding]; other site
99287012652	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
99287012653	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
99287012654	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
99287012655	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
99287012656	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
99287012657	active site pocket [active]
99287012658	oxyanion hole [active]
99287012659	catalytic triad [active]
99287012660	active site nucleophile [active]
99287012661	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
99287012662	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
99287012663	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
99287012664	RNA binding surface [nucleotide binding]; other site
99287012665	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
99287012666	probable active site [active]
99287012667	hypothetical protein; Provisional; Region: PRK10515
99287012668	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
99287012669	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
99287012670	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
99287012671	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
99287012672	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
99287012673	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
99287012674	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
99287012675	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
99287012676	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
99287012677	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
99287012678	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
99287012679	Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948
99287012680	Phage baseplate assembly protein W [General function prediction only]; Region: COG3628
99287012681	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
99287012682	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
99287012683	Ligand binding site; other site
99287012684	Putative Catalytic site; other site
99287012685	DXD motif; other site
99287012686	Predicted membrane protein [Function unknown]; Region: COG2246
99287012687	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
99287012688	Phage protein D [General function prediction only]; Region: COG3500
99287012689	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
99287012690	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
99287012691	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
99287012692	Phage tail tube protein FII [General function prediction only]; Region: COG3498
99287012693	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
99287012694	Gp37 protein; Region: Gp37; pfam09646
99287012695	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
99287012696	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
99287012697	N-acetyl-D-glucosamine binding site [chemical binding]; other site
99287012698	catalytic residue [active]
99287012699	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
99287012700	Mor transcription activator family; Region: Mor; pfam08765
99287012701	aspartate kinase III; Validated; Region: PRK09084
99287012702	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
99287012703	nucleotide binding site [chemical binding]; other site
99287012704	substrate binding site [chemical binding]; other site
99287012705	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
99287012706	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
99287012707	dimer interface [polypeptide binding]; other site
99287012708	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
99287012709	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
99287012710	active site
99287012711	dimer interface [polypeptide binding]; other site
99287012712	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
99287012713	dimer interface [polypeptide binding]; other site
99287012714	active site
99287012715	Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106
99287012716	Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102
99287012717	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
99287012718	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
99287012719	Predicted membrane protein [Function unknown]; Region: COG3223
99287012720	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
99287012721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287012722	dimer interface [polypeptide binding]; other site
99287012723	conserved gate region; other site
99287012724	putative PBP binding loops; other site
99287012725	ABC-ATPase subunit interface; other site
99287012726	maltose transporter membrane protein; Provisional; Region: malF; PRK10999
99287012727	Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785
99287012728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
99287012729	dimer interface [polypeptide binding]; other site
99287012730	conserved gate region; other site
99287012731	putative PBP binding loops; other site
99287012732	ABC-ATPase subunit interface; other site
99287012733	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
99287012734	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
99287012735	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
99287012736	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
99287012737	Walker A/P-loop; other site
99287012738	ATP binding site [chemical binding]; other site
99287012739	Q-loop/lid; other site
99287012740	ABC transporter signature motif; other site
99287012741	Walker B; other site
99287012742	D-loop; other site
99287012743	H-loop/switch region; other site
99287012744	TOBE domain; Region: TOBE_2; pfam08402
99287012745	maltoporin; Provisional; Region: lamB; PRK09360
99287012746	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
99287012747	trimer interface; other site
99287012748	sugar binding site [chemical binding]; other site
99287012749	maltose regulon periplasmic protein; Provisional; Region: PRK10564
99287012750	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
99287012751	4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959
99287012752	putative active site [active]
99287012753	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
99287012754	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
99287012755	putative acyl-acceptor binding pocket; other site
99287012756	Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264
99287012757	putative active site [active]
99287012758	trimer interface [polypeptide binding]; other site
99287012759	putative active site [active]
99287012760	Zn binding site [ion binding]; other site
99287012761	LexA repressor; Validated; Region: PRK00215
99287012762	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
99287012763	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
99287012764	Catalytic site [active]
99287012765	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
99287012766	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
99287012767	hypothetical protein; Provisional; Region: PRK10428
99287012768	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
99287012769	metal binding site 2 [ion binding]; metal-binding site
99287012770	putative DNA binding helix; other site
99287012771	metal binding site 1 [ion binding]; metal-binding site
99287012772	dimer interface [polypeptide binding]; other site
99287012773	structural Zn2+ binding site [ion binding]; other site
99287012774	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
99287012775	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
99287012776	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
99287012777	FMN binding site [chemical binding]; other site
99287012778	active site
99287012779	catalytic residues [active]
99287012780	substrate binding site [chemical binding]; other site
99287012781	phage shock protein G; Reviewed; Region: pspG; PRK09459
99287012782	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
99287012783	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
99287012784	NADP binding site [chemical binding]; other site
99287012785	dimer interface [polypeptide binding]; other site
99287012786	replicative DNA helicase; Provisional; Region: PRK08006
99287012787	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
99287012788	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
99287012789	Walker A motif; other site
99287012790	ATP binding site [chemical binding]; other site
99287012791	Walker B motif; other site
99287012792	DNA binding loops [nucleotide binding]
99287012793	alanine racemase; Reviewed; Region: alr; PRK00053
99287012794	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
99287012795	active site
99287012796	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
99287012797	substrate binding site [chemical binding]; other site
99287012798	catalytic residues [active]
99287012799	dimer interface [polypeptide binding]; other site
99287012800	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
99287012801	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
99287012802	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287012803	homodimer interface [polypeptide binding]; other site
99287012804	catalytic residue [active]
99287012805	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
99287012806	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287012807	active site
99287012808	motif I; other site
99287012809	motif II; other site
99287012810	Uncharacterized conserved protein [Function unknown]; Region: COG0432
99287012811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
99287012812	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
99287012813	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
99287012814	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
99287012815	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
99287012816	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
99287012817	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
99287012818	dimer interface [polypeptide binding]; other site
99287012819	ssDNA binding site [nucleotide binding]; other site
99287012820	tetramer (dimer of dimers) interface [polypeptide binding]; other site
99287012821	putative single-stranded DNA-binding protein; Region: PHA01740
99287012822	SPI-4; Salmonella pathogenicity island 4; required for intracellular survival in macrophages; similar to sequence found in GenBank Accession Number AF060869
99287012823	hypothetical protein; Validated; Region: PRK09039
99287012824	Zinc finger-containing protein; Region: zf-C4H2; pfam10146
99287012825	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
99287012826	Outer membrane efflux protein; Region: OEP; pfam02321
99287012827	Outer membrane efflux protein; Region: OEP; pfam02321
99287012828	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
99287012829	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
99287012830	HlyD family secretion protein; Region: HlyD_3; pfam13437
99287012831	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
99287012832	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012833	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012834	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
99287012835	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012836	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012837	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012838	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
99287012839	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
99287012840	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012841	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
99287012842	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
99287012843	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012844	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
99287012845	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012846	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
99287012847	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
99287012848	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012849	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
99287012850	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012851	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
99287012852	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
99287012853	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012854	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
99287012855	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012856	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
99287012857	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
99287012858	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012859	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012860	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012861	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
99287012862	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012863	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012864	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012865	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012866	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012867	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012868	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012869	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
99287012870	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012871	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012872	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
99287012873	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012874	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012875	Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245
99287012876	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012877	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012878	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
99287012879	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
99287012880	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012881	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
99287012882	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
99287012883	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
99287012884	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287012885	Walker A/P-loop; other site
99287012886	ATP binding site [chemical binding]; other site
99287012887	Q-loop/lid; other site
99287012888	ABC transporter signature motif; other site
99287012889	Walker B; other site
99287012890	D-loop; other site
99287012891	H-loop/switch region; other site
99287012892	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
99287012893	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
99287012894	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287012895	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
99287012896	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287012897	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
99287012898	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
99287012899	DNA binding residues [nucleotide binding]
99287012900	dimer interface [polypeptide binding]; other site
99287012901	[2Fe-2S] cluster binding site [ion binding]; other site
99287012902	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
99287012903	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
99287012904	putative C-terminal domain interface [polypeptide binding]; other site
99287012905	putative GSH binding site (G-site) [chemical binding]; other site
99287012906	putative dimer interface [polypeptide binding]; other site
99287012907	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
99287012908	putative N-terminal domain interface [polypeptide binding]; other site
99287012909	putative dimer interface [polypeptide binding]; other site
99287012910	putative substrate binding pocket (H-site) [chemical binding]; other site
99287012911	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
99287012912	Sulfate transporter family; Region: Sulfate_transp; cl19250
99287012913	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
99287012914	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
99287012915	Transcriptional regulator [Transcription]; Region: LysR; COG0583
99287012916	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287012917	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
99287012918	putative dimerization interface [polypeptide binding]; other site
99287012919	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
99287012920	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
99287012921	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
99287012922	Na binding site [ion binding]; other site
99287012923	Predicted membrane protein [Function unknown]; Region: COG3162
99287012924	acetyl-CoA synthetase; Provisional; Region: PRK00174
99287012925	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
99287012926	active site
99287012927	CoA binding site [chemical binding]; other site
99287012928	acyl-activating enzyme (AAE) consensus motif; other site
99287012929	AMP binding site [chemical binding]; other site
99287012930	acetate binding site [chemical binding]; other site
99287012931	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
99287012932	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
99287012933	Cytochrome c3; Region: Cytochrom_c3_2; pfam14537
99287012934	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
99287012935	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287012936	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
99287012937	heme lyase subunit NrfE; Provisional; Region: PRK10369
99287012938	formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144
99287012939	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
99287012940	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
99287012941	binding surface
99287012942	TPR motif; other site
99287012943	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
99287012944	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
99287012945	Sel1-like repeats; Region: SEL1; smart00671
99287012946	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
99287012947	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
99287012948	[4Fe-4S] binding site [ion binding]; other site
99287012949	molybdopterin cofactor binding site; other site
99287012950	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
99287012951	molybdopterin cofactor binding site; other site
99287012952	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
99287012953	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287012954	Coenzyme A binding pocket [chemical binding]; other site
99287012955	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
99287012956	dimer interface [polypeptide binding]; other site
99287012957	hypothetical protein; Provisional; Region: PRK10220
99287012958	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
99287012959	PhnA protein; Region: PhnA; pfam03831
99287012960	proline/glycine betaine transporter; Provisional; Region: PRK10642
99287012961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287012962	putative substrate translocation pore; other site
99287012963	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
99287012964	sensor protein BasS/PmrB; Provisional; Region: PRK10755
99287012965	HAMP domain; Region: HAMP; pfam00672
99287012966	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287012967	dimer interface [polypeptide binding]; other site
99287012968	phosphorylation site [posttranslational modification]
99287012969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287012970	ATP binding site [chemical binding]; other site
99287012971	Mg2+ binding site [ion binding]; other site
99287012972	G-X-G motif; other site
99287012973	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
99287012974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287012975	active site
99287012976	phosphorylation site [posttranslational modification]
99287012977	intermolecular recognition site; other site
99287012978	dimerization interface [polypeptide binding]; other site
99287012979	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287012980	DNA binding site [nucleotide binding]
99287012981	putative metal dependent hydrolase; Provisional; Region: PRK11598
99287012982	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
99287012983	Sulfatase; Region: Sulfatase; pfam00884
99287012984	arginine:agmatin antiporter; Provisional; Region: PRK10644
99287012985	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
99287012986	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287012987	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99287012988	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287012989	arginine decarboxylase; Provisional; Region: PRK15029
99287012990	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
99287012991	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
99287012992	homodimer interface [polypeptide binding]; other site
99287012993	pyridoxal 5'-phosphate binding site [chemical binding]; other site
99287012994	catalytic residue [active]
99287012995	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
99287012996	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
99287012997	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287012998	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287012999	alpha-galactosidase; Provisional; Region: PRK15076
99287013000	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
99287013001	NAD binding site [chemical binding]; other site
99287013002	sugar binding site [chemical binding]; other site
99287013003	divalent metal binding site [ion binding]; other site
99287013004	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
99287013005	dimer interface [polypeptide binding]; other site
99287013006	melibiose:sodium symporter; Provisional; Region: PRK10429
99287013007	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
99287013008	fumarate hydratase FumB; Provisional; Region: PRK15391
99287013009	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
99287013010	Fumarase C-terminus; Region: Fumerase_C; pfam05683
99287013011	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
99287013012	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
99287013013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287013014	active site
99287013015	phosphorylation site [posttranslational modification]
99287013016	intermolecular recognition site; other site
99287013017	dimerization interface [polypeptide binding]; other site
99287013018	sensory histidine kinase DcuS; Provisional; Region: PRK11086
99287013019	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
99287013020	PAS domain; Region: PAS; smart00091
99287013021	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
99287013022	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
99287013023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287013024	ATP binding site [chemical binding]; other site
99287013025	Mg2+ binding site [ion binding]; other site
99287013026	G-X-G motif; other site
99287013027	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
99287013028	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
99287013029	putative [Fe4-S4] binding site [ion binding]; other site
99287013030	putative molybdopterin cofactor binding site [chemical binding]; other site
99287013031	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
99287013032	putative molybdopterin cofactor binding site; other site
99287013033	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
99287013034	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
99287013035	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
99287013036	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
99287013037	Domain of unknown function (DUF1996); Region: DUF1996; pfam09362
99287013038	SdiA-regulated; Region: SdiA-regulated; cd09971
99287013039	putative active site [active]
99287013040	Transposase IS200 like; Region: Y1_Tnp; pfam01797
99287013041	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99287013042	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
99287013043	DNA binding residues [nucleotide binding]
99287013044	dimerization interface [polypeptide binding]; other site
99287013045	AraC family transcriptional regulator; Provisional; Region: PRK15186
99287013046	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
99287013047	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287013048	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287013049	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
99287013050	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287013051	Coenzyme A binding pocket [chemical binding]; other site
99287013052	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
99287013053	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
99287013054	active site
99287013055	EthD domain; Region: EthD; pfam07110
99287013056	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
99287013057	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
99287013058	DNA binding residues [nucleotide binding]
99287013059	putative dimer interface [polypeptide binding]; other site
99287013060	putative transcriptional regulator; Provisional; Region: PRK11640
99287013061	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
99287013062	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
99287013063	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
99287013064	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
99287013065	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
99287013066	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
99287013067	DsbD alpha interface [polypeptide binding]; other site
99287013068	catalytic residues [active]
99287013069	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
99287013070	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
99287013071	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
99287013072	Aspartase; Region: Aspartase; cd01357
99287013073	active sites [active]
99287013074	tetramer interface [polypeptide binding]; other site
99287013075	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
99287013076	putative transporter; Provisional; Region: PRK11021
99287013077	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
99287013078	oligomerisation interface [polypeptide binding]; other site
99287013079	mobile loop; other site
99287013080	roof hairpin; other site
99287013081	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
99287013082	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
99287013083	ring oligomerisation interface [polypeptide binding]; other site
99287013084	ATP/Mg binding site [chemical binding]; other site
99287013085	stacking interactions; other site
99287013086	hinge regions; other site
99287013087	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
99287013088	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
99287013089	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287013090	FeS/SAM binding site; other site
99287013091	elongation factor P; Validated; Region: PRK00529
99287013092	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
99287013093	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
99287013094	RNA binding site [nucleotide binding]; other site
99287013095	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
99287013096	RNA binding site [nucleotide binding]; other site
99287013097	Predicted small secreted protein [Function unknown]; Region: COG5510
99287013098	entericidin B membrane lipoprotein; Provisional; Region: PRK10081
99287013099	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99287013100	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287013101	DNA binding residues [nucleotide binding]
99287013102	dimerization interface [polypeptide binding]; other site
99287013103	multidrug efflux system protein; Provisional; Region: PRK11431
99287013104	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
99287013105	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
99287013106	Iron-sulfur protein interface; other site
99287013107	proximal quinone binding site [chemical binding]; other site
99287013108	C-subunit interface; other site
99287013109	distal quinone binding site; other site
99287013110	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
99287013111	D-subunit interface [polypeptide binding]; other site
99287013112	Iron-sulfur protein interface; other site
99287013113	proximal quinone binding site [chemical binding]; other site
99287013114	distal quinone binding site [chemical binding]; other site
99287013115	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
99287013116	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
99287013117	catalytic loop [active]
99287013118	iron binding site [ion binding]; other site
99287013119	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
99287013120	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
99287013121	L-aspartate oxidase; Provisional; Region: PRK06175
99287013122	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
99287013123	poxB regulator PoxA; Provisional; Region: PRK09350
99287013124	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
99287013125	motif 1; other site
99287013126	dimer interface [polypeptide binding]; other site
99287013127	active site
99287013128	motif 2; other site
99287013129	motif 3; other site
99287013130	inner membrane transporter YjeM; Provisional; Region: PRK15238
99287013131	Protein of unknown function (DUF2645); Region: DUF2645; pfam10840
99287013132	putative mechanosensitive channel protein; Provisional; Region: PRK10929
99287013133	Mu-like prophage I protein; Region: Mu-like_Pro; cl19864
99287013134	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
99287013135	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
99287013136	Mechanosensitive ion channel; Region: MS_channel; pfam00924
99287013137	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
99287013138	GTPase RsgA; Reviewed; Region: PRK12288
99287013139	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
99287013140	RNA binding site [nucleotide binding]; other site
99287013141	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
99287013142	GTPase/Zn-binding domain interface [polypeptide binding]; other site
99287013143	GTP/Mg2+ binding site [chemical binding]; other site
99287013144	G4 box; other site
99287013145	G5 box; other site
99287013146	G1 box; other site
99287013147	Switch I region; other site
99287013148	G2 box; other site
99287013149	G3 box; other site
99287013150	Switch II region; other site
99287013151	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
99287013152	catalytic site [active]
99287013153	putative active site [active]
99287013154	putative substrate binding site [chemical binding]; other site
99287013155	dimer interface [polypeptide binding]; other site
99287013156	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
99287013157	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
99287013158	substrate binding pocket [chemical binding]; other site
99287013159	membrane-bound complex binding site; other site
99287013160	hinge residues; other site
99287013161	epoxyqueuosine reductase; Region: TIGR00276
99287013162	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
99287013163	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
99287013164	putative carbohydrate kinase; Provisional; Region: PRK10565
99287013165	Uncharacterized conserved protein [Function unknown]; Region: COG0062
99287013166	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
99287013167	putative substrate binding site [chemical binding]; other site
99287013168	putative ATP binding site [chemical binding]; other site
99287013169	ADP-binding protein; Provisional; Region: PRK10646
99287013170	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
99287013171	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
99287013172	AMIN domain; Region: AMIN; pfam11741
99287013173	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
99287013174	active site
99287013175	metal binding site [ion binding]; metal-binding site
99287013176	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
99287013177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287013178	ATP binding site [chemical binding]; other site
99287013179	Mg2+ binding site [ion binding]; other site
99287013180	G-X-G motif; other site
99287013181	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
99287013182	ATP binding site [chemical binding]; other site
99287013183	MutL C terminal dimerization domain; Region: MutL_C; pfam08676
99287013184	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
99287013185	bacterial Hfq-like; Region: Hfq; cd01716
99287013186	hexamer interface [polypeptide binding]; other site
99287013187	Sm1 motif; other site
99287013188	RNA binding site [nucleotide binding]; other site
99287013189	Sm2 motif; other site
99287013190	GTPase HflX; Provisional; Region: PRK11058
99287013191	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
99287013192	HflX GTPase family; Region: HflX; cd01878
99287013193	G1 box; other site
99287013194	GTP/Mg2+ binding site [chemical binding]; other site
99287013195	Switch I region; other site
99287013196	G2 box; other site
99287013197	G3 box; other site
99287013198	Switch II region; other site
99287013199	G4 box; other site
99287013200	G5 box; other site
99287013201	FtsH protease regulator HflK; Provisional; Region: PRK10930
99287013202	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
99287013203	High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404
99287013204	HflC protein; Region: hflC; TIGR01932
99287013205	High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405
99287013206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
99287013207	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
99287013208	GDP-binding site [chemical binding]; other site
99287013209	ACT binding site; other site
99287013210	IMP binding site; other site
99287013211	transcriptional repressor NsrR; Provisional; Region: PRK11014
99287013212	Rrf2 family protein; Region: rrf2_super; TIGR00738
99287013213	exoribonuclease R; Provisional; Region: PRK11642
99287013214	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
99287013215	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
99287013216	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
99287013217	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
99287013218	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
99287013219	RNA binding site [nucleotide binding]; other site
99287013220	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
99287013221	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
99287013222	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
99287013223	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789
99287013224	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
99287013225	Ion channel; Region: Ion_trans_2; pfam07885
99287013226	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
99287013227	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
99287013228	Predicted membrane protein [Function unknown]; Region: COG3766
99287013229	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
99287013230	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
99287013231	Predicted integral membrane protein [Function unknown]; Region: COG5463
99287013232	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
99287013233	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
99287013234	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
99287013235	FAD binding site [chemical binding]; other site
99287013236	substrate binding site [chemical binding]; other site
99287013237	catalytic residues [active]
99287013238	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
99287013239	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
99287013240	esterase; Provisional; Region: PRK10566
99287013241	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
99287013242	transcriptional repressor UlaR; Provisional; Region: PRK13509
99287013243	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
99287013244	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
99287013245	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
99287013246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
99287013247	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
99287013248	active site
99287013249	P-loop; other site
99287013250	phosphorylation site [posttranslational modification]
99287013251	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
99287013252	active site
99287013253	phosphorylation site [posttranslational modification]
99287013254	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
99287013255	active site
99287013256	dimer interface [polypeptide binding]; other site
99287013257	magnesium binding site [ion binding]; other site
99287013258	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
99287013259	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
99287013260	AP (apurinic/apyrimidinic) site pocket; other site
99287013261	DNA interaction; other site
99287013262	Metal-binding active site; metal-binding site
99287013263	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
99287013264	intersubunit interface [polypeptide binding]; other site
99287013265	active site
99287013266	Zn2+ binding site [ion binding]; other site
99287013267	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
99287013268	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
99287013269	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
99287013270	dimer interface [polypeptide binding]; other site
99287013271	ssDNA binding site [nucleotide binding]; other site
99287013272	tetramer (dimer of dimers) interface [polypeptide binding]; other site
99287013273	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
99287013274	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
99287013275	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
99287013276	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
99287013277	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
99287013278	EamA-like transporter family; Region: EamA; pfam00892
99287013279	EamA-like transporter family; Region: EamA; pfam00892
99287013280	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
99287013281	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
99287013282	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
99287013283	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
99287013284	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
99287013285	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
99287013286	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
99287013287	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
99287013288	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
99287013289	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
99287013290	Fe binding site [ion binding]; other site
99287013291	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
99287013292	EamA-like transporter family; Region: EamA; pfam00892
99287013293	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
99287013294	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
99287013295	NADP binding site [chemical binding]; other site
99287013296	Predicted transcriptional regulators [Transcription]; Region: COG1733
99287013297	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
99287013298	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
99287013299	active site
99287013300	metal binding site [ion binding]; metal-binding site
99287013301	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
99287013302	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
99287013303	active site
99287013304	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
99287013305	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
99287013306	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
99287013307	Domain of unknown function DUF21; Region: DUF21; pfam01595
99287013308	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
99287013309	Transporter associated domain; Region: CorC_HlyC; smart01091
99287013310	methionine sulfoxide reductase A; Provisional; Region: PRK00058
99287013311	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
99287013312	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
99287013313	Surface antigen; Region: Bac_surface_Ag; pfam01103
99287013314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
99287013315	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
99287013316	Family of unknown function (DUF490); Region: DUF490; pfam04357
99287013317	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
99287013318	putative active site pocket [active]
99287013319	dimerization interface [polypeptide binding]; other site
99287013320	putative catalytic residue [active]
99287013321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287013322	D-galactonate transporter; Region: 2A0114; TIGR00893
99287013323	putative substrate translocation pore; other site
99287013324	putative metallo-dependent hydrolase; Provisional; Region: PRK12394
99287013325	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
99287013326	active site
99287013327	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
99287013328	dimer interface [polypeptide binding]; other site
99287013329	substrate binding site [chemical binding]; other site
99287013330	metal binding sites [ion binding]; metal-binding site
99287013331	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
99287013332	AMP binding site [chemical binding]; other site
99287013333	metal binding site [ion binding]; metal-binding site
99287013334	active site
99287013335	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
99287013336	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
99287013337	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
99287013338	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
99287013339	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
99287013340	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
99287013341	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
99287013342	putative active site [active]
99287013343	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
99287013344	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287013345	putative substrate translocation pore; other site
99287013346	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
99287013347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287013348	putative substrate translocation pore; other site
99287013349	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
99287013350	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
99287013351	tetrameric interface [polypeptide binding]; other site
99287013352	NAD binding site [chemical binding]; other site
99287013353	catalytic residues [active]
99287013354	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
99287013355	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287013356	Helix-turn-helix domain; Region: HTH_18; pfam12833
99287013357	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287013358	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
99287013359	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
99287013360	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
99287013361	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99287013362	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
99287013363	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
99287013364	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
99287013365	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
99287013366	major facilitator superfamily transporter; Provisional; Region: PRK05122
99287013367	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287013368	putative substrate translocation pore; other site
99287013369	sugar kinase; ribokinase family; contains frameshifts
99287013370	thiamine pyrophosphate-requiring enzyme; similar to Escherichia coli acetolactate synthase I; valine-sensitive; large subunit (AAC76694.1); similar to Escherichia coli glyoxylate carboligase (AAC73609.1); contains frameshifts
99287013371	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
99287013372	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
99287013373	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
99287013374	polyol permease family; Region: 2A0118; TIGR00897
99287013375	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287013376	putative substrate translocation pore; other site
99287013377	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
99287013378	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
99287013379	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
99287013380	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
99287013381	hypothetical protein; Provisional; Region: PRK05255
99287013382	peptidase PmbA; Provisional; Region: PRK11040
99287013383	cytochrome b562; Provisional; Region: PRK15058
99287013384	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
99287013385	Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272
99287013386	conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578
99287013387	conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580
99287013388	Domain of unknown function (DUF4310); Region: DUF4310; pfam14187
99287013389	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
99287013390	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
99287013391	active site
99287013392	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
99287013393	Protein of unknown function (DUF1341); Region: DUF1341; pfam07071
99287013394	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
99287013395	HTH domain; Region: HTH_11; pfam08279
99287013396	Mga helix-turn-helix domain; Region: Mga; pfam05043
99287013397	PRD domain; Region: PRD; pfam00874
99287013398	PRD domain; Region: PRD; pfam00874
99287013399	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
99287013400	active site
99287013401	P-loop; other site
99287013402	phosphorylation site [posttranslational modification]
99287013403	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
99287013404	active site
99287013405	phosphorylation site [posttranslational modification]
99287013406	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
99287013407	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
99287013408	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
99287013409	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287013410	FeS/SAM binding site; other site
99287013411	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
99287013412	ATP cone domain; Region: ATP-cone; pfam03477
99287013413	Class III ribonucleotide reductase; Region: RNR_III; cd01675
99287013414	effector binding site; other site
99287013415	active site
99287013416	Zn binding site [ion binding]; other site
99287013417	glycine loop; other site
99287013418	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
99287013419	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
99287013420	Ca binding site [ion binding]; other site
99287013421	active site
99287013422	catalytic site [active]
99287013423	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
99287013424	trehalose repressor; Provisional; Region: treR; PRK09492
99287013425	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287013426	DNA binding site [nucleotide binding]
99287013427	domain linker motif; other site
99287013428	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
99287013429	dimerization interface [polypeptide binding]; other site
99287013430	ligand binding site [chemical binding]; other site
99287013431	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
99287013432	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
99287013433	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
99287013434	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
99287013435	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287013436	motif II; other site
99287013437	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
99287013438	Transposase; Region: HTH_Tnp_1; cl17663
99287013439	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
99287013440	homotrimer interaction site [polypeptide binding]; other site
99287013441	putative active site [active]
99287013442	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
99287013443	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
99287013444	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
99287013445	aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670
99287013446	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
99287013447	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
99287013448	pyrBI operon leader peptide; Provisional; Region: PRK10224
99287013449	Arginine repressor [Transcription]; Region: ArgR; COG1438
99287013450	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
99287013451	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
99287013452	Predicted membrane protein [Function unknown]; Region: COG1288
99287013453	ornithine carbamoyltransferase; Validated; Region: PRK02102
99287013454	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
99287013455	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
99287013456	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
99287013457	putative substrate binding site [chemical binding]; other site
99287013458	nucleotide binding site [chemical binding]; other site
99287013459	nucleotide binding site [chemical binding]; other site
99287013460	homodimer interface [polypeptide binding]; other site
99287013461	arginine deiminase; Provisional; Region: PRK01388
99287013462	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
99287013463	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
99287013464	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
99287013465	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
99287013466	RNase E inhibitor protein; Provisional; Region: PRK11191
99287013467	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
99287013468	active site
99287013469	dinuclear metal binding site [ion binding]; other site
99287013470	dimerization interface [polypeptide binding]; other site
99287013471	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
99287013472	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
99287013473	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287013474	Coenzyme A binding pocket [chemical binding]; other site
99287013475	Predicted membrane protein [Function unknown]; Region: COG4269
99287013476	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
99287013477	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
99287013478	active site
99287013479	HIGH motif; other site
99287013480	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
99287013481	KMSKS motif; other site
99287013482	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
99287013483	tRNA binding surface [nucleotide binding]; other site
99287013484	anticodon binding site; other site
99287013485	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
99287013486	DNA polymerase III subunit chi; Validated; Region: PRK05728
99287013487	multifunctional aminopeptidase A; Provisional; Region: PRK00913
99287013488	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
99287013489	interface (dimer of trimers) [polypeptide binding]; other site
99287013490	Substrate-binding/catalytic site; other site
99287013491	Zn-binding sites [ion binding]; other site
99287013492	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
99287013493	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
99287013494	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
99287013495	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
99287013496	DNA binding site [nucleotide binding]
99287013497	domain linker motif; other site
99287013498	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
99287013499	putative dimerization interface [polypeptide binding]; other site
99287013500	putative ligand binding site [chemical binding]; other site
99287013501	fructuronate transporter; Provisional; Region: PRK10034; cl15264
99287013502	GntP family permease; Region: GntP_permease; pfam02447
99287013503	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
99287013504	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
99287013505	NADP binding site [chemical binding]; other site
99287013506	homodimer interface [polypeptide binding]; other site
99287013507	active site
99287013508	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
99287013509	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
99287013510	putative NAD(P) binding site [chemical binding]; other site
99287013511	catalytic Zn binding site [ion binding]; other site
99287013512	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
99287013513	AAA domain; Region: AAA_33; pfam13671
99287013514	ATP-binding site [chemical binding]; other site
99287013515	Gluconate-6-phosphate binding site [chemical binding]; other site
99287013516	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
99287013517	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
99287013518	putative NAD(P) binding site [chemical binding]; other site
99287013519	putative substrate binding site [chemical binding]; other site
99287013520	catalytic Zn binding site [ion binding]; other site
99287013521	structural Zn binding site [ion binding]; other site
99287013522	dimer interface [polypeptide binding]; other site
99287013523	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
99287013524	replicative DNA helicase; Provisional; Region: PRK05973
99287013525	Part of AAA domain; Region: AAA_19; pfam13245
99287013526	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
99287013527	AAA domain; Region: AAA_12; pfam13087
99287013528	C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118
99287013529	putative active site [active]
99287013530	catalytic site [active]
99287013531	Uncharacterized conserved protein [Function unknown]; Region: COG4127
99287013532	conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653
99287013533	Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337
99287013534	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
99287013535	TIGR02687 family protein; Region: TIGR02687
99287013536	PglZ domain; Region: PglZ; pfam08665
99287013537	Protein of unknown function (DUF4435); Region: DUF4435; pfam14491
99287013538	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
99287013539	Predicted ATPases [General function prediction only]; Region: COG1106
99287013540	Walker A/P-loop; other site
99287013541	ATP binding site [chemical binding]; other site
99287013542	AAA domain; Region: AAA_21; pfam13304
99287013543	ABC transporter signature motif; other site
99287013544	Walker B; other site
99287013545	D-loop; other site
99287013546	H-loop/switch region; other site
99287013547	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
99287013548	Methyltransferase domain; Region: Methyltransf_26; pfam13659
99287013549	TIGR02680 family protein; Region: TIGR02680
99287013550	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
99287013551	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
99287013552	hypothetical protein; Provisional; Region: PRK12378
99287013553	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287013554	S-adenosylmethionine binding site [chemical binding]; other site
99287013555	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
99287013556	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287013557	S-adenosylmethionine binding site [chemical binding]; other site
99287013558	hypothetical protein; Provisional; Region: PRK13687
99287013559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332
99287013560	Uncharacterized conserved protein [Function unknown]; Region: COG3439
99287013561	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
99287013562	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
99287013563	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
99287013564	DNA-binding site [nucleotide binding]; DNA binding site
99287013565	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
99287013566	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
99287013567	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
99287013568	active site
99287013569	HIGH motif; other site
99287013570	dimer interface [polypeptide binding]; other site
99287013571	KMSKS motif; other site
99287013572	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
99287013573	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
99287013574	cell density-dependent motility repressor; Provisional; Region: PRK10082
99287013575	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287013576	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
99287013577	dimerization interface [polypeptide binding]; other site
99287013578	isoaspartyl dipeptidase; Provisional; Region: PRK10657
99287013579	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
99287013580	active site
99287013581	hypothetical protein; Provisional; Region: PRK10519
99287013582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
99287013583	Nucleoside recognition; Region: Gate; pfam07670
99287013584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287013585	Major Facilitator Superfamily; Region: MFS_1; pfam07690
99287013586	putative substrate translocation pore; other site
99287013587	Predicted membrane protein [Function unknown]; Region: COG2733
99287013588	Protein of unknown function (DUF445); Region: DUF445; pfam04286
99287013589	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
99287013590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
99287013591	putative substrate translocation pore; other site
99287013592	hypothetical protein; Provisional; Region: PRK09956
99287013593	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
99287013594	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
99287013595	NAD(P) binding site [chemical binding]; other site
99287013596	catalytic residues [active]
99287013597	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
99287013598	endoribonuclease SymE; Provisional; Region: PRK13605
99287013599	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
99287013600	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
99287013601	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
99287013602	HsdM N-terminal domain; Region: HsdM_N; pfam12161
99287013603	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
99287013604	Methyltransferase domain; Region: Methyltransf_26; pfam13659
99287013605	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
99287013606	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
99287013607	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
99287013608	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
99287013609	ATP binding site [chemical binding]; other site
99287013610	putative Mg++ binding site [ion binding]; other site
99287013611	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
99287013612	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
99287013613	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
99287013614	Mrr N-terminal domain; Region: Mrr_N; pfam14338
99287013615	Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030
99287013616	Restriction endonuclease; Region: Mrr_cat; pfam04471
99287013617	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
99287013618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
99287013619	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
99287013620	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
99287013621	P-loop, Walker A motif; other site
99287013622	Base recognition motif; other site
99287013623	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
99287013624	Uncharacterized small protein [Function unknown]; Region: COG2879
99287013625	carbon starvation protein A; Provisional; Region: PRK15015
99287013626	Carbon starvation protein CstA; Region: CstA; pfam02554
99287013627	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
99287013628	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
99287013629	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
99287013630	dimer interface [polypeptide binding]; other site
99287013631	ligand binding site [chemical binding]; other site
99287013632	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287013633	dimerization interface [polypeptide binding]; other site
99287013634	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
99287013635	dimer interface [polypeptide binding]; other site
99287013636	putative CheW interface [polypeptide binding]; other site
99287013637	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
99287013638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287013639	Walker A motif; other site
99287013640	ATP binding site [chemical binding]; other site
99287013641	Walker B motif; other site
99287013642	arginine finger; other site
99287013643	Transcriptional antiterminator [Transcription]; Region: COG3933
99287013644	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
99287013645	active pocket/dimerization site; other site
99287013646	active site
99287013647	phosphorylation site [posttranslational modification]
99287013648	PRD domain; Region: PRD; pfam00874
99287013649	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
99287013650	active pocket/dimerization site; other site
99287013651	active site
99287013652	phosphorylation site [posttranslational modification]
99287013653	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
99287013654	active site
99287013655	phosphorylation site [posttranslational modification]
99287013656	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
99287013657	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
99287013658	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
99287013659	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
99287013660	dimer interface [polypeptide binding]; other site
99287013661	active site
99287013662	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
99287013663	dimer interface [polypeptide binding]; other site
99287013664	active site
99287013665	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
99287013666	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
99287013667	putative active site [active]
99287013668	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
99287013669	phosphoglycerol transferase I; Provisional; Region: PRK03776
99287013670	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
99287013671	hypothetical protein; Provisional; Region: PRK11667
99287013672	DNA replication protein DnaC; Validated; Region: PRK07952
99287013673	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287013674	Walker A motif; other site
99287013675	ATP binding site [chemical binding]; other site
99287013676	Walker B motif; other site
99287013677	primosomal protein DnaI; Provisional; Region: PRK02854
99287013678	hypothetical protein; Provisional; Region: PRK09917
99287013679	Uncharacterized conserved protein [Function unknown]; Region: COG2966
99287013680	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
99287013681	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
99287013682	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287013683	DNA binding residues [nucleotide binding]
99287013684	dimerization interface [polypeptide binding]; other site
99287013685	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
99287013686	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287013687	DNA binding residues [nucleotide binding]
99287013688	dimerization interface [polypeptide binding]; other site
99287013689	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
99287013690	putative deacylase active site [active]
99287013691	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
99287013692	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
99287013693	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
99287013694	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
99287013695	metal binding site [ion binding]; metal-binding site
99287013696	active site
99287013697	I-site; other site
99287013698	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
99287013699	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
99287013700	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
99287013701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
99287013702	S-adenosylmethionine binding site [chemical binding]; other site
99287013703	DNA polymerase III subunit psi; Validated; Region: PRK06856
99287013704	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
99287013705	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
99287013706	Coenzyme A binding pocket [chemical binding]; other site
99287013707	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
99287013708	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287013709	motif II; other site
99287013710	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
99287013711	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
99287013712	G1 box; other site
99287013713	putative GEF interaction site [polypeptide binding]; other site
99287013714	GTP/Mg2+ binding site [chemical binding]; other site
99287013715	Switch I region; other site
99287013716	G2 box; other site
99287013717	G3 box; other site
99287013718	Switch II region; other site
99287013719	G4 box; other site
99287013720	G5 box; other site
99287013721	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
99287013722	Elongation Factor G, domain II; Region: EFG_II; pfam14492
99287013723	periplasmic protein; Provisional; Region: PRK10568
99287013724	BON domain; Region: BON; pfam04972
99287013725	BON domain; Region: BON; pfam04972
99287013726	Small integral membrane protein [Function unknown]; Region: COG5487
99287013727	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
99287013728	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
99287013729	active site
99287013730	nucleophile elbow; other site
99287013731	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
99287013732	active site
99287013733	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
99287013734	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
99287013735	FeS/SAM binding site; other site
99287013736	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
99287013737	hypothetical protein; Provisional; Region: PRK10977
99287013738	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
99287013739	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
99287013740	intersubunit interface [polypeptide binding]; other site
99287013741	active site
99287013742	catalytic residue [active]
99287013743	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
99287013744	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
99287013745	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
99287013746	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
99287013747	phosphopentomutase; Provisional; Region: PRK05362
99287013748	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
99287013749	hypothetical protein; Provisional; Region: PRK15301
99287013750	putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304
99287013751	PapC N-terminal domain; Region: PapC_N; pfam13954
99287013752	Outer membrane usher protein; Region: Usher; pfam00577
99287013753	PapC C-terminal domain; Region: PapC_C; pfam13953
99287013754	putative fimbrial chaperone protein; Provisional; Region: PRK09918
99287013755	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287013756	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287013757	hypothetical protein; Provisional; Region: PRK15302
99287013758	hypothetical protein; Provisional; Region: PRK15303
99287013759	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
99287013760	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
99287013761	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
99287013762	hypothetical protein; Provisional; Region: PRK11246
99287013763	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
99287013764	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
99287013765	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
99287013766	motif II; other site
99287013767	DNA repair protein RadA; Region: sms; TIGR00416
99287013768	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
99287013769	Walker A motif/ATP binding site; other site
99287013770	ATP binding site [chemical binding]; other site
99287013771	Walker B motif; other site
99287013772	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
99287013773	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
99287013774	non-specific DNA binding site [nucleotide binding]; other site
99287013775	salt bridge; other site
99287013776	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
99287013777	sequence-specific DNA binding site [nucleotide binding]; other site
99287013778	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
99287013779	active site
99287013780	(T/H)XGH motif; other site
99287013781	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
99287013782	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
99287013783	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
99287013784	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
99287013785	ABC transporter; Region: ABC_tran_2; pfam12848
99287013786	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
99287013787	lytic murein transglycosylase; Provisional; Region: PRK11619
99287013788	Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718
99287013789	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
99287013790	N-acetyl-D-glucosamine binding site [chemical binding]; other site
99287013791	catalytic residue [active]
99287013792	Trp operon repressor; Provisional; Region: PRK01381
99287013793	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
99287013794	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
99287013795	catalytic core [active]
99287013796	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
99287013797	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287013798	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287013799	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
99287013800	hypothetical protein; Provisional; Region: PRK10756
99287013801	DNA-binding response regulator CreB; Provisional; Region: PRK11083
99287013802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287013803	active site
99287013804	phosphorylation site [posttranslational modification]
99287013805	intermolecular recognition site; other site
99287013806	dimerization interface [polypeptide binding]; other site
99287013807	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287013808	DNA binding site [nucleotide binding]
99287013809	sensory histidine kinase CreC; Provisional; Region: PRK11100
99287013810	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
99287013811	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
99287013812	dimerization interface [polypeptide binding]; other site
99287013813	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
99287013814	dimer interface [polypeptide binding]; other site
99287013815	phosphorylation site [posttranslational modification]
99287013816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
99287013817	ATP binding site [chemical binding]; other site
99287013818	Mg2+ binding site [ion binding]; other site
99287013819	G-X-G motif; other site
99287013820	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
99287013821	putative major fimbrial protein SthE; Provisional; Region: PRK15292
99287013822	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
99287013823	putative fimbrial protein SthD; Provisional; Region: PRK15293
99287013824	putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294
99287013825	PapC N-terminal domain; Region: PapC_N; pfam13954
99287013826	Outer membrane usher protein; Region: Usher; pfam00577
99287013827	PapC C-terminal domain; Region: PapC_C; pfam13953
99287013828	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
99287013829	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287013830	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287013831	putative fimbrial protein SthA; Provisional; Region: PRK15296
99287013832	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
99287013833	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
99287013834	two-component response regulator; Provisional; Region: PRK11173
99287013835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
99287013836	active site
99287013837	phosphorylation site [posttranslational modification]
99287013838	intermolecular recognition site; other site
99287013839	dimerization interface [polypeptide binding]; other site
99287013840	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
99287013841	DNA binding site [nucleotide binding]
99287013842	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
99287013843	putative RNA methyltransferase; Provisional; Region: PRK10433
99287013844	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
99287013845	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
99287013846	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
99287013847	putative active site [active]
99287013848	catalytic site [active]
99287013849	replication protein; Provisional; Region: PRK13702
99287013850	RepA leader peptide Tap; Provisional; Region: PRK14745
99287013851	replication protein; Provisional; Region: PRK13750
99287013852	similar to C-terminus of outer membrane protein; similar to PSLT010
99287013853	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
99287013854	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
99287013855	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
99287013856	resistance to complement killing; Provisional; Region: PRK15240
99287013857	SdiA-regulated; Region: SdiA-regulated; cd09971
99287013858	putative active site [active]
99287013859	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
99287013860	catalytic residues [active]
99287013861	hinge region; other site
99287013862	alpha helical domain; other site
99287013863	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
99287013864	DNA binding residues [nucleotide binding]
99287013865	dimerization interface [polypeptide binding]; other site
99287013866	FaeA-like protein; Region: FaeA; pfam04703
99287013867	fimbrial chaperone protein PefD; Provisional; Region: PRK15211
99287013868	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
99287013869	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
99287013870	fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213
99287013871	PapC N-terminal domain; Region: PapC_N; pfam13954
99287013872	Outer membrane usher protein; Region: Usher; pfam00577
99287013873	fimbrial protein PefA; Provisional; Region: PRK15214
99287013874	Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333
99287013875	contains frameshifts; similar to orf from Salmonella enteritidis virulence plasmid
99287013876	putative replication region of RepFIB
99287013877	similar to recombinase; contains frameshifts
99287013878	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
99287013879	plasmid maintenance protein CcdA; Provisional; Region: PRK13710
99287013880	plasmid maintenance protein CcdB; Provisional; Region: PRK13708
99287013881	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
99287013882	active site
99287013883	catalytic residues [active]
99287013884	DNA binding site [nucleotide binding]
99287013885	Int/Topo IB signature motif; other site
99287013886	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
99287013887	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
99287013888	bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782
99287013889	contains frameshifts; similar to adhesin
99287013890	contains frameshifts; similar to transposase
99287013891	Transposase IS200 like; Region: Y1_Tnp; pfam01797
99287013892	virulence protein SpvD; Provisional; Region: PRK15250
99287013893	type III effector phosphothreonine lyase; Provisional; Region: PRK15245
99287013894	virulence protein SpvB; Provisional; Region: PRK15244
99287013895	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
99287013896	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
99287013897	active site
99287013898	conformational flexibility of ligand binding pocket; other site
99287013899	ADP-ribosylating toxin turn-turn motif; other site
99287013900	virulence protein SpvA; Provisional; Region: PRK15212
99287013901	similar to C-terminus of Gifsy-2 prophage lysozyme
99287013902	transcriptional regulator SpvR; Provisional; Region: PRK15243
99287013903	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
99287013904	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
99287013905	Homeodomain-like domain; Region: HTH_23; pfam13384
99287013906	Winged helix-turn helix; Region: HTH_29; pfam13551
99287013907	Homeodomain-like domain; Region: HTH_32; pfam13565
99287013908	DDE superfamily endonuclease; Region: DDE_3; pfam13358
99287013909	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
99287013910	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
99287013911	Walker A motif; other site
99287013912	ATP binding site [chemical binding]; other site
99287013913	Walker B motif; other site
99287013914	Integrase core domain; Region: rve; pfam00665
99287013915	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
99287013916	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
99287013917	catalytic residues [active]
99287013918	catalytic nucleophile [active]
99287013919	Presynaptic Site I dimer interface [polypeptide binding]; other site
99287013920	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
99287013921	Synaptic Flat tetramer interface [polypeptide binding]; other site
99287013922	Synaptic Site I dimer interface [polypeptide binding]; other site
99287013923	DNA binding site [nucleotide binding]
99287013924	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
99287013925	DNA-binding interface [nucleotide binding]; DNA binding site
99287013926	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
99287013927	active site clefts [active]
99287013928	zinc binding site [ion binding]; other site
99287013929	dimer interface [polypeptide binding]; other site
99287013930	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
99287013931	contains frameshifts; similar to DNA polymerase III epsilon subunit; similar to orf41 from Salmonella enteritidis virulence plasmid
99287013932	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
99287013933	Uncharacterized conserved protein [Function unknown]; Region: COG5464
99287013934	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
99287013935	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
99287013936	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
99287013937	P-loop; other site
99287013938	Magnesium ion binding site [ion binding]; other site
99287013939	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
99287013940	ParB-like nuclease domain; Region: ParBc; pfam02195
99287013941	ParB family; Region: ParB; pfam08775
99287013942	centromere for plasmid partition
99287013943	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
99287013944	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
99287013945	active site
99287013946	DNA binding site [nucleotide binding]
99287013947	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
99287013948	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
99287013949	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
99287013950	Catalytic site [active]
99287013951	putative methylase; Provisional; Region: PRK13699
99287013952	contains frameshifts; similar to orf160 from plasmid ColIb-P9
99287013953	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
99287013954	Antirestriction protein; Region: Antirestrict; pfam03230
99287013955	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
99287013956	DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440
99287013957	similar to repeat-containing protein
99287013958	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
99287013959	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
99287013960	dimer interface [polypeptide binding]; other site
99287013961	ssDNA binding site [nucleotide binding]; other site
99287013962	tetramer (dimer of dimers) interface [polypeptide binding]; other site
99287013963	Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006
99287013964	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
99287013965	ParB-like nuclease domain; Region: ParBc; pfam02195
99287013966	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
99287013967	Plasmid SOS inhibition protein (PsiB); Region: PsiB; pfam06290
99287013968	PsiA protein; Region: PsiA; pfam06952
99287013969	contains frameshifts; similar to plasmid R1 gene32 and plasmid F ORF273
99287013970	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
99287013971	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
99287013972	N-acetyl-D-glucosamine binding site [chemical binding]; other site
99287013973	catalytic residue [active]
99287013974	conjugal transfer protein TraM; Provisional; Region: PRK13713
99287013975	conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719
99287013976	PAS domain; Region: PAS_8; pfam13188
99287013977	putative Dam methylation site
99287013978	conjugal transfer protein TraY; Provisional; Region: PRK13740
99287013979	TraY domain; Region: TraY; pfam05509
99287013980	conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734
99287013981	conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707
99287013982	conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726
99287013983	conjugal transfer protein TraK; Provisional; Region: PRK13736
99287013984	conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729
99287013985	Aflatoxin regulatory protein; Region: AflR; pfam08493
99287013986	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
99287013987	TraP protein; Region: TraP; pfam07296
99287013988	conjugal transfer protein TrbD; Provisional; Region: PRK13724
99287013989	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
99287013990	conjugal transfer protein TraV; Provisional; Region: PRK13733
99287013991	conjugal transfer protein TraR; Provisional; Region: PRK13715
99287013992	conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721
99287013993	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
99287013994	Domain of unknown function DUF87; Region: DUF87; cl19135
99287013995	conjugal transfer protein TrbI; Provisional; Region: PRK13717
99287013996	conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738
99287013997	conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737
99287013998	conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730
99287013999	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
99287014000	active site
99287014001	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
99287014002	type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750
99287014003	conjugal transfer protein TrbE; Provisional; Region: PRK13718
99287014004	conjugal pilus assembly protein TraF; Provisional; Region: PRK13703
99287014005	conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727
99287014006	conjugal transfer protein TrbB; Provisional; Region: PRK13728
99287014007	conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723
99287014008	conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735
99287014009	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
99287014010	Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624
99287014011	conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731
99287014012	conjugal transfer protein TraD; Provisional; Region: PRK13700
99287014013	F sex factor protein N terminal; Region: TraD_N; pfam12615
99287014014	Bacterial conjugation protein TrwB,  ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127
99287014015	multimer interface [polypeptide binding]; other site
99287014016	Walker A motif; other site
99287014017	ATP binding site [chemical binding]; other site
99287014018	Walker B motif; other site
99287014019	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
99287014020	oligomeric interface; other site
99287014021	putative active site [active]
99287014022	homodimer interface [polypeptide binding]; other site
99287014023	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
99287014024	conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709
99287014025	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
99287014026	AAA domain; Region: AAA_30; pfam13604
99287014027	DNA helicase TraI; Region: TraI; pfam07057
99287014028	conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706
99287014029	conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754
99287014030	Fertility inhibition protein N terminal; Region: FinO_N; pfam12602
99287014031	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
99287014032	putative kissing complex interaction region; other site
99287014033	putative RNA binding sites [nucleotide binding]; other site