-- dump date   	20140620_055338
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
216597000001	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
216597000002	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
216597000003	putative catalytic residues [active]
216597000004	putative nucleotide binding site [chemical binding]; other site
216597000005	putative aspartate binding site [chemical binding]; other site
216597000006	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
216597000007	dimer interface [polypeptide binding]; other site
216597000008	putative threonine allosteric regulatory site; other site
216597000009	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
216597000010	putative threonine allosteric regulatory site; other site
216597000011	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
216597000012	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
216597000013	homoserine kinase; Provisional; Region: PRK01212
216597000014	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
216597000015	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
216597000016	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
216597000017	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597000018	catalytic residue [active]
216597000019	hypothetical protein; Validated; Region: PRK02101
216597000020	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
216597000021	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
216597000022	transaldolase-like protein; Provisional; Region: PTZ00411
216597000023	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
216597000024	active site
216597000025	dimer interface [polypeptide binding]; other site
216597000026	catalytic residue [active]
216597000027	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
216597000028	MPT binding site; other site
216597000029	trimer interface [polypeptide binding]; other site
216597000030	hypothetical protein; Provisional; Region: PRK10659
216597000031	hypothetical protein; Provisional; Region: PRK10236
216597000032	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
216597000033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
216597000034	Protein of unknown function (DUF2541); Region: DUF2541; pfam10807
216597000035	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
216597000036	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
216597000037	nucleotide binding site [chemical binding]; other site
216597000038	chaperone protein DnaJ; Provisional; Region: PRK10767
216597000039	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
216597000040	HSP70 interaction site [polypeptide binding]; other site
216597000041	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
216597000042	substrate binding site [polypeptide binding]; other site
216597000043	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
216597000044	Zn binding sites [ion binding]; other site
216597000045	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
216597000046	dimer interface [polypeptide binding]; other site
216597000047	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597000048	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597000049	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
216597000050	substrate binding pocket [chemical binding]; other site
216597000051	dimerization interface [polypeptide binding]; other site
216597000052	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
216597000053	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
216597000054	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
216597000055	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
216597000056	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
216597000057	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
216597000058	active site
216597000059	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
216597000060	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
216597000061	aromatic chitin/cellulose binding site residues [chemical binding]; other site
216597000062	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
216597000063	Helix-turn-helix domain; Region: HTH_36; pfam13730
216597000064	fimbrial protein BcfA; Provisional; Region: PRK15187
216597000065	fimbrial chaperone protein BcfB; Provisional; Region: PRK15188
216597000066	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597000067	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597000068	outer membrane usher protein; Provisional; Region: PRK15193
216597000069	PapC N-terminal domain; Region: PapC_N; pfam13954
216597000070	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216597000071	PapC C-terminal domain; Region: PapC_C; pfam13953
216597000072	fimbrial protein BcfD; Provisional; Region: PRK15189
216597000073	fimbrial protein BcfE; Provisional; Region: PRK15190
216597000074	fimbrial protein BcfF; Provisional; Region: PRK15191
216597000075	fimbrial chaperone BcfG; Provisional; Region: PRK15192
216597000076	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597000077	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597000078	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
216597000079	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
216597000080	catalytic residues [active]
216597000081	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
216597000082	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597000083	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597000084	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216597000085	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
216597000086	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
216597000087	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
216597000088	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
216597000089	active site
216597000090	metal binding site [ion binding]; metal-binding site
216597000091	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
216597000092	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
216597000093	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
216597000094	Sulfatase; Region: Sulfatase; pfam00884
216597000095	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
216597000096	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597000097	FeS/SAM binding site; other site
216597000098	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
216597000099	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
216597000100	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
216597000101	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
216597000102	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
216597000103	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597000104	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
216597000105	putative dimerization interface [polypeptide binding]; other site
216597000106	putative alpha-glucosidase; Provisional; Region: PRK10658
216597000107	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
216597000108	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
216597000109	putative active site [active]
216597000110	putative catalytic site [active]
216597000111	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
216597000112	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
216597000113	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
216597000114	Protein of unknown function (DUF2575); Region: DUF2575; pfam10837
216597000115	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
216597000116	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
216597000117	active site
216597000118	Riboflavin kinase; Region: Flavokinase; smart00904
216597000119	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
216597000120	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
216597000121	active site
216597000122	HIGH motif; other site
216597000123	nucleotide binding site [chemical binding]; other site
216597000124	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
216597000125	active site
216597000126	KMSKS motif; other site
216597000127	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
216597000128	tRNA binding surface [nucleotide binding]; other site
216597000129	anticodon binding site; other site
216597000130	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
216597000131	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
216597000132	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
216597000133	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
216597000134	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
216597000135	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
216597000136	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
216597000137	active site
216597000138	tetramer interface [polypeptide binding]; other site
216597000139	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
216597000140	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597000141	active site
216597000142	phosphorylation site [posttranslational modification]
216597000143	intermolecular recognition site; other site
216597000144	dimerization interface [polypeptide binding]; other site
216597000145	Transcriptional regulator; Region: CitT; pfam12431
216597000146	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
216597000147	PAS domain; Region: PAS; smart00091
216597000148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597000149	ATP binding site [chemical binding]; other site
216597000150	Mg2+ binding site [ion binding]; other site
216597000151	G-X-G motif; other site
216597000152	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
216597000153	oxaloacetate decarboxylase; Provisional; Region: PRK14040
216597000154	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
216597000155	active site
216597000156	catalytic residues [active]
216597000157	metal binding site [ion binding]; metal-binding site
216597000158	homodimer binding site [polypeptide binding]; other site
216597000159	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
216597000160	carboxyltransferase (CT) interaction site; other site
216597000161	biotinylation site [posttranslational modification]; other site
216597000162	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
216597000163	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
216597000164	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
216597000165	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
216597000166	putative active site [active]
216597000167	(T/H)XGH motif; other site
216597000168	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
216597000169	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
216597000170	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
216597000171	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
216597000172	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
216597000173	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
216597000174	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
216597000175	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
216597000176	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
216597000178	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
216597000179	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
216597000180	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
216597000181	catalytic site [active]
216597000182	subunit interface [polypeptide binding]; other site
216597000183	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
216597000184	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216597000185	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
216597000186	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
216597000187	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216597000188	ATP-grasp domain; Region: ATP-grasp_4; cl17255
216597000189	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
216597000190	IMP binding site; other site
216597000191	dimer interface [polypeptide binding]; other site
216597000192	interdomain contacts; other site
216597000193	partial ornithine binding site; other site
216597000194	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
216597000195	carnitine operon protein CaiE; Provisional; Region: PRK13627
216597000196	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
216597000197	putative trimer interface [polypeptide binding]; other site
216597000198	putative metal binding site [ion binding]; other site
216597000199	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
216597000200	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216597000201	substrate binding site [chemical binding]; other site
216597000202	oxyanion hole (OAH) forming residues; other site
216597000203	trimer interface [polypeptide binding]; other site
216597000204	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
216597000205	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
216597000206	acyl-activating enzyme (AAE) consensus motif; other site
216597000207	putative AMP binding site [chemical binding]; other site
216597000208	putative active site [active]
216597000209	putative CoA binding site [chemical binding]; other site
216597000211	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
216597000212	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
216597000213	active site
216597000214	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
216597000215	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
216597000216	Ligand binding site [chemical binding]; other site
216597000217	Electron transfer flavoprotein domain; Region: ETF; pfam01012
216597000218	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
216597000219	Electron transfer flavoprotein domain; Region: ETF; smart00893
216597000220	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
216597000221	putative oxidoreductase FixC; Provisional; Region: PRK10157
216597000222	ferredoxin-like protein FixX; Provisional; Region: PRK15449
216597000223	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597000224	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
216597000225	putative substrate translocation pore; other site
216597000226	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
216597000227	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
216597000228	lacks the C-terminal region
216597000229	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
216597000230	Sulfatase; Region: Sulfatase; cl17466
216597000231	Sulfatase; Region: Sulfatase; cl17466
216597000232	Sulfatase; Region: Sulfatase; cl17466
216597000233	lacks the N-terminal region
216597000234	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
216597000235	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
216597000236	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
216597000237	TrkA-N domain; Region: TrkA_N; pfam02254
216597000238	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
216597000239	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
216597000240	folate binding site [chemical binding]; other site
216597000241	NADP+ binding site [chemical binding]; other site
216597000242	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
216597000243	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
216597000244	active site
216597000245	metal binding site [ion binding]; metal-binding site
216597000246	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
216597000247	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
216597000248	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
216597000249	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
216597000250	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
216597000251	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
216597000252	SurA N-terminal domain; Region: SurA_N; pfam09312
216597000253	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
216597000254	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
216597000255	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
216597000256	OstA-like protein; Region: OstA; pfam03968
216597000257	Organic solvent tolerance protein; Region: OstA_C; pfam04453
216597000258	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
216597000259	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
216597000260	putative metal binding site [ion binding]; other site
216597000261	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
216597000262	HSP70 interaction site [polypeptide binding]; other site
216597000263	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
216597000264	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
216597000265	active site
216597000266	ATP-dependent helicase HepA; Validated; Region: PRK04914
216597000267	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216597000268	ATP binding site [chemical binding]; other site
216597000269	putative Mg++ binding site [ion binding]; other site
216597000270	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597000271	nucleotide binding region [chemical binding]; other site
216597000272	ATP-binding site [chemical binding]; other site
216597000273	DNA polymerase II; Reviewed; Region: PRK05762
216597000274	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
216597000275	active site
216597000276	catalytic site [active]
216597000277	substrate binding site [chemical binding]; other site
216597000278	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
216597000279	active site
216597000280	metal-binding site
216597000281	Uncharacterized conserved protein [Function unknown]; Region: COG1434
216597000282	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
216597000283	putative active site [active]
216597000284	lacks C-terminal region
216597000285	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
216597000286	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
216597000287	intersubunit interface [polypeptide binding]; other site
216597000288	active site
216597000289	Zn2+ binding site [ion binding]; other site
216597000290	L-arabinose isomerase; Provisional; Region: PRK02929
216597000291	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
216597000292	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
216597000293	trimer interface [polypeptide binding]; other site
216597000294	putative substrate binding site [chemical binding]; other site
216597000295	putative metal binding site [ion binding]; other site
216597000296	ribulokinase; Provisional; Region: PRK04123
216597000297	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
216597000298	N- and C-terminal domain interface [polypeptide binding]; other site
216597000299	active site
216597000300	MgATP binding site [chemical binding]; other site
216597000301	catalytic site [active]
216597000302	metal binding site [ion binding]; metal-binding site
216597000303	carbohydrate binding site [chemical binding]; other site
216597000304	homodimer interface [polypeptide binding]; other site
216597000305	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
216597000306	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216597000307	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597000308	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597000309	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
216597000310	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
216597000311	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
216597000312	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
216597000313	Walker A/P-loop; other site
216597000314	ATP binding site [chemical binding]; other site
216597000315	Q-loop/lid; other site
216597000316	ABC transporter signature motif; other site
216597000317	Walker B; other site
216597000318	D-loop; other site
216597000319	H-loop/switch region; other site
216597000320	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
216597000321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597000322	dimer interface [polypeptide binding]; other site
216597000323	conserved gate region; other site
216597000324	putative PBP binding loops; other site
216597000325	ABC-ATPase subunit interface; other site
216597000326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597000327	dimer interface [polypeptide binding]; other site
216597000328	conserved gate region; other site
216597000329	putative PBP binding loops; other site
216597000330	ABC-ATPase subunit interface; other site
216597000331	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
216597000332	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
216597000333	transcriptional regulator SgrR; Provisional; Region: PRK13626
216597000334	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
216597000335	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
216597000336	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
216597000337	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
216597000338	substrate binding site [chemical binding]; other site
216597000339	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
216597000340	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
216597000341	substrate binding site [chemical binding]; other site
216597000342	ligand binding site [chemical binding]; other site
216597000343	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
216597000344	tartrate dehydrogenase; Region: TTC; TIGR02089
216597000345	2-isopropylmalate synthase; Validated; Region: PRK00915
216597000346	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
216597000347	active site
216597000348	catalytic residues [active]
216597000349	metal binding site [ion binding]; metal-binding site
216597000350	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
216597000351	leu operon leader peptide; Provisional; Region: PRK14744
216597000352	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
216597000353	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597000354	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
216597000355	putative substrate binding pocket [chemical binding]; other site
216597000356	putative dimerization interface [polypeptide binding]; other site
216597000357	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
216597000358	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
216597000359	dimer interface [polypeptide binding]; other site
216597000360	PYR/PP interface [polypeptide binding]; other site
216597000361	TPP binding site [chemical binding]; other site
216597000362	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216597000363	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
216597000364	TPP-binding site [chemical binding]; other site
216597000365	dimer interface [polypeptide binding]; other site
216597000366	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
216597000367	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
216597000368	putative valine binding site [chemical binding]; other site
216597000369	dimer interface [polypeptide binding]; other site
216597000370	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
216597000371	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
216597000372	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597000373	DNA binding site [nucleotide binding]
216597000374	domain linker motif; other site
216597000375	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
216597000376	dimerization interface [polypeptide binding]; other site
216597000377	ligand binding site [chemical binding]; other site
216597000378	mraZ protein; Region: TIGR00242
216597000379	MraZ protein; Region: MraZ; pfam02381
216597000380	MraZ protein; Region: MraZ; pfam02381
216597000381	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
216597000382	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
216597000383	cell division protein FtsL; Provisional; Region: PRK10772
216597000384	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
216597000385	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
216597000386	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
216597000387	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
216597000388	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
216597000389	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216597000390	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
216597000391	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
216597000392	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
216597000393	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216597000394	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
216597000395	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
216597000396	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
216597000397	Mg++ binding site [ion binding]; other site
216597000398	putative catalytic motif [active]
216597000399	putative substrate binding site [chemical binding]; other site
216597000400	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
216597000401	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216597000402	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
216597000403	cell division protein FtsW; Provisional; Region: PRK10774
216597000404	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
216597000405	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
216597000406	active site
216597000407	homodimer interface [polypeptide binding]; other site
216597000408	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
216597000409	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
216597000410	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216597000411	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
216597000412	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
216597000413	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
216597000414	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
216597000415	cell division protein FtsQ; Provisional; Region: PRK10775
216597000416	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
216597000417	Cell division protein FtsQ; Region: FtsQ; pfam03799
216597000418	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
216597000419	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
216597000420	Cell division protein FtsA; Region: FtsA; pfam14450
216597000421	cell division protein FtsZ; Validated; Region: PRK09330
216597000422	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
216597000423	nucleotide binding site [chemical binding]; other site
216597000424	SulA interaction site; other site
216597000425	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
216597000426	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
216597000427	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
216597000428	SecA regulator SecM; Provisional; Region: PRK02943
216597000429	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
216597000430	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
216597000431	SEC-C motif; Region: SEC-C; pfam02810
216597000432	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
216597000433	active site
216597000434	8-oxo-dGMP binding site [chemical binding]; other site
216597000435	nudix motif; other site
216597000436	metal binding site [ion binding]; metal-binding site
216597000437	DNA gyrase inhibitor; Reviewed; Region: PRK00418
216597000438	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
216597000439	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
216597000440	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
216597000441	CoA-binding site [chemical binding]; other site
216597000442	ATP-binding [chemical binding]; other site
216597000443	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
216597000444	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
216597000445	active site
216597000446	type IV pilin biogenesis protein; Provisional; Region: PRK10573
216597000447	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216597000448	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216597000449	hypothetical protein; Provisional; Region: PRK10436
216597000450	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
216597000451	Walker A motif; other site
216597000452	ATP binding site [chemical binding]; other site
216597000453	Walker B motif; other site
216597000454	putative major pilin subunit; Provisional; Region: PRK10574
216597000455	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
216597000456	Pilin (bacterial filament); Region: Pilin; pfam00114
216597000457	nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078
216597000458	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
216597000459	dimerization interface [polypeptide binding]; other site
216597000460	active site
216597000461	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
216597000462	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
216597000463	amidase catalytic site [active]
216597000464	Zn binding residues [ion binding]; other site
216597000465	substrate binding site [chemical binding]; other site
216597000466	regulatory protein AmpE; Provisional; Region: PRK10987
216597000467	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
216597000468	active site
216597000469	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
216597000470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597000471	putative substrate translocation pore; other site
216597000472	aromatic amino acid transporter; Provisional; Region: PRK10238
216597000473	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
216597000474	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597000475	DNA-binding site [nucleotide binding]; DNA binding site
216597000476	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216597000477	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
216597000478	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
216597000479	dimer interface [polypeptide binding]; other site
216597000480	TPP-binding site [chemical binding]; other site
216597000481	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
216597000482	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
216597000483	E3 interaction surface; other site
216597000484	lipoyl attachment site [posttranslational modification]; other site
216597000485	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
216597000486	E3 interaction surface; other site
216597000487	lipoyl attachment site [posttranslational modification]; other site
216597000488	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
216597000489	E3 interaction surface; other site
216597000490	lipoyl attachment site [posttranslational modification]; other site
216597000491	e3 binding domain; Region: E3_binding; pfam02817
216597000492	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
216597000493	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
216597000494	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216597000495	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216597000496	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
216597000497	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
216597000499	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
216597000500	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
216597000501	substrate binding site [chemical binding]; other site
216597000502	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
216597000503	substrate binding site [chemical binding]; other site
216597000504	ligand binding site [chemical binding]; other site
216597000505	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
216597000506	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
216597000507	hypothetical protein; Provisional; Region: PRK05248
216597000508	2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460
216597000509	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
216597000510	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
216597000511	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
216597000512	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
216597000513	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
216597000514	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216597000515	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
216597000516	spermidine synthase; Provisional; Region: PRK00811
216597000517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597000518	S-adenosylmethionine binding site [chemical binding]; other site
216597000519	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
216597000520	multicopper oxidase; Provisional; Region: PRK10965
216597000521	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
216597000522	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
216597000523	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
216597000524	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
216597000525	Trp docking motif [polypeptide binding]; other site
216597000526	putative active site [active]
216597000527	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
216597000528	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216597000529	active site
216597000530	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
216597000531	active site clefts [active]
216597000532	zinc binding site [ion binding]; other site
216597000533	dimer interface [polypeptide binding]; other site
216597000534	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
216597000535	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
216597000536	Walker A/P-loop; other site
216597000537	ATP binding site [chemical binding]; other site
216597000538	Q-loop/lid; other site
216597000539	ABC transporter signature motif; other site
216597000540	Walker B; other site
216597000541	D-loop; other site
216597000542	H-loop/switch region; other site
216597000543	inner membrane transport permease; Provisional; Region: PRK15066
216597000544	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
216597000545	putative fimbrial protein StiH; Provisional; Region: PRK15297
216597000546	fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298
216597000547	PapC N-terminal domain; Region: PapC_N; pfam13954
216597000548	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216597000549	PapC C-terminal domain; Region: PapC_C; pfam13953
216597000550	fimbrial chaperone protein StiB; Provisional; Region: PRK15299
216597000551	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597000552	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597000553	fimbrial protein StiA; Provisional; Region: PRK15300
216597000554	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
216597000555	active pocket/dimerization site; other site
216597000556	active site
216597000557	phosphorylation site [posttranslational modification]
216597000558	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
216597000559	putative active site [active]
216597000560	putative metal binding site [ion binding]; other site
216597000561	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
216597000562	tetramerization interface [polypeptide binding]; other site
216597000563	active site
216597000564	Pantoate-beta-alanine ligase; Region: PanC; cd00560
216597000565	pantoate--beta-alanine ligase; Region: panC; TIGR00018
216597000566	active site
216597000567	ATP-binding site [chemical binding]; other site
216597000568	pantoate-binding site; other site
216597000569	HXXH motif; other site
216597000570	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
216597000571	oligomerization interface [polypeptide binding]; other site
216597000572	active site
216597000573	metal binding site [ion binding]; metal-binding site
216597000574	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
216597000575	catalytic center binding site [active]
216597000576	ATP binding site [chemical binding]; other site
216597000577	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
216597000578	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
216597000579	active site
216597000580	NTP binding site [chemical binding]; other site
216597000581	metal binding triad [ion binding]; metal-binding site
216597000582	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
216597000583	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
216597000584	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
216597000585	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
216597000586	active site
216597000587	nucleotide binding site [chemical binding]; other site
216597000588	HIGH motif; other site
216597000589	KMSKS motif; other site
216597000590	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
216597000591	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
216597000592	2'-5' RNA ligase; Provisional; Region: PRK15124
216597000593	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
216597000594	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
216597000595	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
216597000596	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216597000597	ATP binding site [chemical binding]; other site
216597000598	putative Mg++ binding site [ion binding]; other site
216597000599	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597000600	nucleotide binding region [chemical binding]; other site
216597000601	ATP-binding site [chemical binding]; other site
216597000602	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
216597000603	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
216597000604	Transglycosylase; Region: Transgly; pfam00912
216597000605	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
216597000606	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
216597000607	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216597000608	N-terminal plug; other site
216597000609	ligand-binding site [chemical binding]; other site
216597000610	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
216597000611	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
216597000612	Walker A/P-loop; other site
216597000613	ATP binding site [chemical binding]; other site
216597000614	Q-loop/lid; other site
216597000615	ABC transporter signature motif; other site
216597000616	Walker B; other site
216597000617	D-loop; other site
216597000618	H-loop/switch region; other site
216597000619	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
216597000620	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
216597000621	siderophore binding site; other site
216597000622	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
216597000623	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216597000624	ABC-ATPase subunit  interface; other site
216597000625	dimer interface [polypeptide binding]; other site
216597000626	putative PBP binding regions; other site
216597000627	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216597000628	ABC-ATPase subunit  interface; other site
216597000629	dimer interface [polypeptide binding]; other site
216597000630	putative PBP binding regions; other site
216597000631	putative fimbrial subunit StfA; Provisional; Region: PRK15283
216597000632	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
216597000633	PapC N-terminal domain; Region: PapC_N; pfam13954
216597000634	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216597000635	PapC C-terminal domain; Region: PapC_C; pfam13953
216597000636	putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285
216597000637	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597000638	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597000639	putative minor fimbrial subunit StfE; Provisional; Region: PRK15286
216597000640	putative minor fimbrial subunit StfF; Provisional; Region: PRK15287
216597000641	putative minor fimbrial subunit StfG; Provisional; Region: PRK15288
216597000642	Protein of unknown function (DUF2544); Region: DUF2544; pfam11245
216597000643	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
216597000644	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216597000645	inhibitor-cofactor binding pocket; inhibition site
216597000646	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597000647	catalytic residue [active]
216597000648	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
216597000649	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
216597000650	Cl- selectivity filter; other site
216597000651	Cl- binding residues [ion binding]; other site
216597000652	pore gating glutamate residue; other site
216597000653	dimer interface [polypeptide binding]; other site
216597000654	H+/Cl- coupling transport residue; other site
216597000655	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
216597000656	hypothetical protein; Provisional; Region: PRK10578
216597000657	UPF0126 domain; Region: UPF0126; pfam03458
216597000658	UPF0126 domain; Region: UPF0126; pfam03458
216597000659	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
216597000660	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
216597000661	cobalamin binding residues [chemical binding]; other site
216597000662	putative BtuC binding residues; other site
216597000663	dimer interface [polypeptide binding]; other site
216597000664	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
216597000665	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
216597000666	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
216597000667	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216597000668	Zn2+ binding site [ion binding]; other site
216597000669	Mg2+ binding site [ion binding]; other site
216597000670	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
216597000671	serine endoprotease; Provisional; Region: PRK10942
216597000672	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
216597000673	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
216597000674	protein binding site [polypeptide binding]; other site
216597000675	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
216597000676	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
216597000677	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
216597000678	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
216597000679	hypothetical protein; Provisional; Region: PRK13677
216597000680	shikimate transporter; Provisional; Region: PRK09952
216597000681	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597000682	putative substrate translocation pore; other site
216597000683	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
216597000684	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
216597000685	trimer interface [polypeptide binding]; other site
216597000686	active site
216597000687	substrate binding site [chemical binding]; other site
216597000688	CoA binding site [chemical binding]; other site
216597000689	PII uridylyl-transferase; Provisional; Region: PRK05007
216597000690	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
216597000691	metal binding triad; other site
216597000692	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
216597000693	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216597000694	Zn2+ binding site [ion binding]; other site
216597000695	Mg2+ binding site [ion binding]; other site
216597000696	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
216597000697	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
216597000698	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
216597000699	active site
216597000700	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
216597000701	rRNA interaction site [nucleotide binding]; other site
216597000702	S8 interaction site; other site
216597000703	putative laminin-1 binding site; other site
216597000704	elongation factor Ts; Provisional; Region: tsf; PRK09377
216597000705	UBA/TS-N domain; Region: UBA; pfam00627
216597000706	Elongation factor TS; Region: EF_TS; pfam00889
216597000707	Elongation factor TS; Region: EF_TS; pfam00889
216597000708	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
216597000709	putative nucleotide binding site [chemical binding]; other site
216597000710	uridine monophosphate binding site [chemical binding]; other site
216597000711	homohexameric interface [polypeptide binding]; other site
216597000712	ribosome recycling factor; Reviewed; Region: frr; PRK00083
216597000713	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
216597000714	hinge region; other site
216597000715	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
216597000716	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
216597000717	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
216597000718	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
216597000719	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
216597000720	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
216597000721	catalytic residue [active]
216597000722	putative FPP diphosphate  binding site; other site
216597000723	putative FPP binding hydrophobic cleft; other site
216597000724	dimer interface [polypeptide binding]; other site
216597000725	putative IPP diphosphate binding site; other site
216597000726	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
216597000727	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
216597000728	zinc metallopeptidase RseP; Provisional; Region: PRK10779
216597000729	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
216597000730	active site
216597000731	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
216597000732	protein binding site [polypeptide binding]; other site
216597000733	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
216597000734	protein binding site [polypeptide binding]; other site
216597000735	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
216597000736	putative substrate binding region [chemical binding]; other site
216597000737	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
216597000738	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216597000739	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216597000740	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216597000741	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216597000742	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216597000743	Surface antigen; Region: Bac_surface_Ag; pfam01103
216597000744	periplasmic chaperone; Provisional; Region: PRK10780
216597000745	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
216597000746	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
216597000747	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
216597000748	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
216597000749	trimer interface [polypeptide binding]; other site
216597000750	active site
216597000751	UDP-GlcNAc binding site [chemical binding]; other site
216597000752	lipid binding site [chemical binding]; lipid-binding site
216597000753	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
216597000754	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
216597000755	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
216597000756	active site
216597000757	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
216597000758	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
216597000759	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
216597000760	RNA/DNA hybrid binding site [nucleotide binding]; other site
216597000761	active site
216597000762	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
216597000763	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
216597000764	putative active site [active]
216597000765	putative PHP Thumb interface [polypeptide binding]; other site
216597000766	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
216597000767	generic binding surface II; other site
216597000768	generic binding surface I; other site
216597000769	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
216597000770	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
216597000771	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
216597000772	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
216597000773	putative sugar binding site [chemical binding]; other site
216597000774	catalytic residues [active]
216597000775	PKD domain; Region: PKD; pfam00801
216597000776	lysine decarboxylase LdcC; Provisional; Region: PRK15399
216597000777	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
216597000778	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
216597000779	homodimer interface [polypeptide binding]; other site
216597000780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597000781	catalytic residue [active]
216597000782	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
216597000783	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
216597000784	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216597000785	putative metal binding site [ion binding]; other site
216597000786	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
216597000787	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
216597000788	TilS substrate binding domain; Region: TilS; pfam09179
216597000789	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
216597000790	Rho-binding antiterminator; Provisional; Region: PRK11625
216597000791	hypothetical protein; Provisional; Region: PRK04964
216597000792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
216597000793	hypothetical protein; Provisional; Region: PRK09256
216597000794	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
216597000795	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
216597000796	NlpE N-terminal domain; Region: NlpE; pfam04170
216597000797	prolyl-tRNA synthetase; Provisional; Region: PRK09194
216597000798	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
216597000799	dimer interface [polypeptide binding]; other site
216597000800	motif 1; other site
216597000801	active site
216597000802	motif 2; other site
216597000803	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
216597000804	putative deacylase active site [active]
216597000805	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
216597000806	active site
216597000807	motif 3; other site
216597000808	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
216597000809	anticodon binding site; other site
216597000810	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
216597000811	homodimer interaction site [polypeptide binding]; other site
216597000812	cofactor binding site; other site
216597000813	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
216597000814	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
216597000815	lipoprotein, YaeC family; Region: TIGR00363
216597000816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597000817	dimer interface [polypeptide binding]; other site
216597000818	conserved gate region; other site
216597000819	ABC-ATPase subunit interface; other site
216597000820	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
216597000821	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
216597000822	Walker A/P-loop; other site
216597000823	ATP binding site [chemical binding]; other site
216597000824	Q-loop/lid; other site
216597000825	ABC transporter signature motif; other site
216597000826	Walker B; other site
216597000827	D-loop; other site
216597000828	H-loop/switch region; other site
216597000829	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
216597000830	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
216597000831	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597000832	active site
216597000833	motif I; other site
216597000834	motif II; other site
216597000835	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216597000836	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216597000837	active site
216597000838	catalytic tetrad [active]
216597000839	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597000840	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597000841	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
216597000842	putative effector binding pocket; other site
216597000843	dimerization interface [polypeptide binding]; other site
216597000844	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
216597000845	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597000846	putative substrate translocation pore; other site
216597000847	hypothetical protein; Provisional; Region: PRK05421
216597000848	putative catalytic site [active]
216597000849	putative metal binding site [ion binding]; other site
216597000850	putative phosphate binding site [ion binding]; other site
216597000851	putative catalytic site [active]
216597000852	putative phosphate binding site [ion binding]; other site
216597000853	putative metal binding site [ion binding]; other site
216597000854	Methyltransferase domain; Region: Methyltransf_23; pfam13489
216597000855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597000856	S-adenosylmethionine binding site [chemical binding]; other site
216597000857	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
216597000858	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216597000859	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216597000860	catalytic residue [active]
216597000861	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216597000862	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216597000863	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
216597000864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597000865	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
216597000866	RNA/DNA hybrid binding site [nucleotide binding]; other site
216597000867	active site
216597000868	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
216597000869	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
216597000870	active site
216597000871	catalytic site [active]
216597000872	substrate binding site [chemical binding]; other site
216597000873	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
216597000874	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
216597000875	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
216597000876	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
216597000877	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
216597000878	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
216597000879	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
216597000880	ImpE protein; Region: ImpE; pfam07024
216597000881	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
216597000882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597000883	Walker A motif; other site
216597000884	ATP binding site [chemical binding]; other site
216597000885	Walker B motif; other site
216597000886	arginine finger; other site
216597000887	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597000888	Walker A motif; other site
216597000889	ATP binding site [chemical binding]; other site
216597000890	Walker B motif; other site
216597000891	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
216597000892	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
216597000893	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
216597000894	Protein of unknown function (DUF877); Region: DUF877; pfam05943
216597000895	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
216597000896	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
216597000897	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
216597000898	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
216597000899	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
216597000900	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
216597000901	hypothetical protein; Provisional; Region: PRK08126
216597000902	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
216597000903	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216597000904	ligand binding site [chemical binding]; other site
216597000905	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
216597000906	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
216597000907	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
216597000908	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
216597000909	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893
216597000910	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
216597000911	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
216597000912	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
216597000913	Uncharacterized conserved protein [Function unknown]; Region: COG5435
216597000914	PAAR motif; Region: PAAR_motif; pfam05488
216597000915	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
216597000916	RHS Repeat; Region: RHS_repeat; pfam05593
216597000917	RHS Repeat; Region: RHS_repeat; pfam05593
216597000918	RHS protein; Region: RHS; pfam03527
216597000919	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
216597000921	carries stop codon in N-terminal region
216597000922	has a frameshift after residue 81
216597000924	lacks the N-terminal region and has three frameshifts after residues 43, 142 and 148
216597000925	Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221
216597000926	pili assembly chaperone protein SafB; Provisional; Region: PRK15224
216597000927	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597000928	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597000929	pilin outer membrane usher protein SafC; Provisional; Region: PRK15223
216597000930	PapC N-terminal domain; Region: PapC_N; pfam13954
216597000931	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216597000932	PapC C-terminal domain; Region: PapC_C; pfam13953
216597000933	putative pilin structural protein SafD; Provisional; Region: PRK15222
216597000934	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
216597000935	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
216597000936	putative active site [active]
216597000937	putative metal binding site [ion binding]; other site
216597000938	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597000939	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597000940	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216597000941	dimerization interface [polypeptide binding]; other site
216597000942	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
216597000943	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
216597000944	dimer interface [polypeptide binding]; other site
216597000945	C-N hydrolase family amidase; Provisional; Region: PRK10438
216597000946	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
216597000947	putative active site [active]
216597000948	catalytic triad [active]
216597000949	dimer interface [polypeptide binding]; other site
216597000950	multimer interface [polypeptide binding]; other site
216597000951	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
216597000952	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216597000953	active site
216597000954	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
216597000955	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
216597000956	dimer interface [polypeptide binding]; other site
216597000957	active site
216597000958	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
216597000959	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
216597000960	putative active site [active]
216597000961	putative dimer interface [polypeptide binding]; other site
216597000962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
216597000963	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
216597000964	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
216597000965	active site
216597000966	DNA polymerase IV; Validated; Region: PRK02406
216597000967	DNA binding site [nucleotide binding]
216597000969	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
216597000970	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
216597000971	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
216597000972	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
216597000973	metal binding site [ion binding]; metal-binding site
216597000974	dimer interface [polypeptide binding]; other site
216597000975	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216597000976	active site
216597000977	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
216597000978	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
216597000979	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
216597000980	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
216597000981	trimer interface [polypeptide binding]; other site
216597000982	eyelet of channel; other site
216597000983	gamma-glutamyl kinase; Provisional; Region: PRK05429
216597000984	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
216597000985	nucleotide binding site [chemical binding]; other site
216597000986	homotetrameric interface [polypeptide binding]; other site
216597000987	putative phosphate binding site [ion binding]; other site
216597000988	putative allosteric binding site; other site
216597000989	PUA domain; Region: PUA; pfam01472
216597000990	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
216597000991	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
216597000992	putative catalytic cysteine [active]
216597000993	HTH-like domain; Region: HTH_21; pfam13276
216597000994	Integrase core domain; Region: rve; pfam00665
216597000995	Integrase core domain; Region: rve_2; pfam13333
216597000996	lacks the N-terminal region and has a frameshift after residue 92
216597000997	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
216597000998	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
216597000999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597001000	putative substrate translocation pore; other site
216597001001	isopropylmalate isomerase large subunit; Provisional; Region: PRK12466
216597001002	substrate binding site [chemical binding]; other site
216597001003	3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066
216597001004	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
216597001005	hypothetical protein; Provisional; Region: PRK14812
216597001006	substrate binding site [chemical binding]; other site
216597001007	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
216597001008	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
216597001009	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216597001010	transcriptional activator TtdR; Provisional; Region: PRK09801
216597001011	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597001012	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
216597001013	putative effector binding pocket; other site
216597001014	putative dimerization interface [polypeptide binding]; other site
216597001015	YjzC-like protein; Region: YjzC; pfam14168
216597001016	fimbrial assembly chaperone StbE; Provisional; Region: PRK15246
216597001017	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597001018	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597001019	putative fimbrial usher protein StbD; Provisional; Region: PRK15247
216597001020	fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248
216597001021	PapC N-terminal domain; Region: PapC_N; pfam13954
216597001022	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216597001023	PapC C-terminal domain; Region: PapC_C; pfam13953
216597001024	fimbrial chaperone protein StbB; Provisional; Region: PRK15249
216597001025	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597001026	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597001027	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
216597001028	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
216597001029	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
216597001030	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597001031	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
216597001032	DNA binding site [nucleotide binding]
216597001033	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
216597001034	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
216597001035	DNA binding residues [nucleotide binding]
216597001036	dimerization interface [polypeptide binding]; other site
216597001037	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
216597001038	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
216597001039	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
216597001040	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216597001041	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
216597001042	HlyD family secretion protein; Region: HlyD_3; pfam13437
216597001043	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
216597001044	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
216597001045	metal-binding site [ion binding]
216597001046	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216597001047	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597001048	motif II; other site
216597001049	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
216597001050	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
216597001051	DNA binding residues [nucleotide binding]
216597001052	dimer interface [polypeptide binding]; other site
216597001053	copper binding site [ion binding]; other site
216597001054	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
216597001055	metal-binding site [ion binding]
216597001056	putative sialic acid transporter; Region: 2A0112; TIGR00891
216597001057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597001058	putative substrate translocation pore; other site
216597001059	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
216597001060	DNA methylase; Region: N6_N4_Mtase; cl17433
216597001061	DNA methylase; Region: N6_N4_Mtase; pfam01555
216597001062	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
216597001063	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
216597001064	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
216597001065	VRR-NUC domain; Region: VRR_NUC; pfam08774
216597001066	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
216597001067	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
216597001068	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
216597001069	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
216597001070	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216597001071	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
216597001072	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216597001073	N-terminal plug; other site
216597001074	ligand-binding site [chemical binding]; other site
216597001075	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
216597001076	hypothetical protein; Provisional; Region: PRK09929
216597001077	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
216597001078	Propionate catabolism activator; Region: PrpR_N; pfam06506
216597001079	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597001080	Walker A motif; other site
216597001081	ATP binding site [chemical binding]; other site
216597001082	Walker B motif; other site
216597001083	arginine finger; other site
216597001084	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216597001085	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
216597001086	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
216597001087	tetramer interface [polypeptide binding]; other site
216597001088	active site
216597001089	Mg2+/Mn2+ binding site [ion binding]; other site
216597001090	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
216597001091	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
216597001092	dimer interface [polypeptide binding]; other site
216597001093	active site
216597001094	citrylCoA binding site [chemical binding]; other site
216597001095	oxalacetate/citrate binding site [chemical binding]; other site
216597001096	coenzyme A binding site [chemical binding]; other site
216597001097	catalytic triad [active]
216597001098	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
216597001099	2-methylcitrate dehydratase; Region: prpD; TIGR02330
216597001100	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
216597001101	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216597001102	acyl-activating enzyme (AAE) consensus motif; other site
216597001103	AMP binding site [chemical binding]; other site
216597001104	active site
216597001105	CoA binding site [chemical binding]; other site
216597001106	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
216597001107	dimer interface [polypeptide binding]; other site
216597001108	active site
216597001109	Schiff base residues; other site
216597001110	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
216597001111	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
216597001112	Autotransporter beta-domain; Region: Autotransporter; pfam03797
216597001113	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
216597001114	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
216597001115	ligand binding site [chemical binding]; other site
216597001116	flexible hinge region; other site
216597001117	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
216597001118	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
216597001119	microcin B17 transporter; Reviewed; Region: PRK11098
216597001120	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
216597001121	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
216597001122	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
216597001123	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
216597001124	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
216597001125	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
216597001126	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
216597001127	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
216597001128	drug efflux system protein MdtG; Provisional; Region: PRK09874
216597001129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597001130	putative substrate translocation pore; other site
216597001131	anti-RssB factor; Provisional; Region: PRK10244
216597001132	hypothetical protein; Provisional; Region: PRK11505
216597001133	psiF repeat; Region: PsiF_repeat; pfam07769
216597001134	psiF repeat; Region: PsiF_repeat; pfam07769
216597001135	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
216597001136	MASE2 domain; Region: MASE2; pfam05230
216597001137	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216597001138	metal binding site [ion binding]; metal-binding site
216597001139	active site
216597001140	I-site; other site
216597001141	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
216597001142	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
216597001143	hypothetical protein; Validated; Region: PRK00124
216597001144	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
216597001145	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
216597001146	ADP binding site [chemical binding]; other site
216597001147	magnesium binding site [ion binding]; other site
216597001148	putative shikimate binding site; other site
216597001149	hypothetical protein; Provisional; Region: PRK10380
216597001150	hypothetical protein; Provisional; Region: PRK10481
216597001151	hypothetical protein; Provisional; Region: PRK10579
216597001152	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
216597001153	fructokinase; Reviewed; Region: PRK09557
216597001154	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
216597001155	nucleotide binding site [chemical binding]; other site
216597001156	MFS transport protein AraJ; Provisional; Region: PRK10091
216597001157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597001158	putative substrate translocation pore; other site
216597001159	exonuclease subunit SbcC; Provisional; Region: PRK10246
216597001160	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597001161	Walker A/P-loop; other site
216597001162	ATP binding site [chemical binding]; other site
216597001163	Q-loop/lid; other site
216597001164	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597001165	ABC transporter signature motif; other site
216597001166	Walker B; other site
216597001167	D-loop; other site
216597001168	H-loop/switch region; other site
216597001169	exonuclease subunit SbcD; Provisional; Region: PRK10966
216597001170	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
216597001171	active site
216597001172	metal binding site [ion binding]; metal-binding site
216597001173	DNA binding site [nucleotide binding]
216597001174	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
216597001175	transcriptional regulator PhoB; Provisional; Region: PRK10161
216597001176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597001177	active site
216597001178	phosphorylation site [posttranslational modification]
216597001179	intermolecular recognition site; other site
216597001180	dimerization interface [polypeptide binding]; other site
216597001181	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597001182	DNA binding site [nucleotide binding]
216597001183	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
216597001184	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
216597001185	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216597001186	putative active site [active]
216597001187	heme pocket [chemical binding]; other site
216597001188	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597001189	dimer interface [polypeptide binding]; other site
216597001190	phosphorylation site [posttranslational modification]
216597001191	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597001192	ATP binding site [chemical binding]; other site
216597001193	Mg2+ binding site [ion binding]; other site
216597001194	G-X-G motif; other site
216597001195	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
216597001196	putative proline-specific permease; Provisional; Region: proY; PRK10580
216597001197	maltodextrin glucosidase; Provisional; Region: PRK10785
216597001198	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
216597001199	homodimer interface [polypeptide binding]; other site
216597001200	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
216597001201	active site
216597001202	homodimer interface [polypeptide binding]; other site
216597001203	catalytic site [active]
216597001204	peroxidase; Provisional; Region: PRK15000
216597001205	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
216597001206	dimer interface [polypeptide binding]; other site
216597001207	decamer (pentamer of dimers) interface [polypeptide binding]; other site
216597001208	catalytic triad [active]
216597001209	peroxidatic and resolving cysteines [active]
216597001210	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
216597001211	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
216597001212	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
216597001213	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
216597001214	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
216597001215	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
216597001216	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
216597001217	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
216597001218	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
216597001219	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
216597001220	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
216597001221	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
216597001222	Protein export membrane protein; Region: SecD_SecF; pfam02355
216597001223	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
216597001224	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216597001225	Predicted transcriptional regulator [Transcription]; Region: COG2378
216597001226	HTH domain; Region: HTH_11; pfam08279
216597001227	WYL domain; Region: WYL; pfam13280
216597001228	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
216597001229	active site
216597001230	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
216597001231	hypothetical protein; Provisional; Region: PRK11530
216597001232	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
216597001233	ATP cone domain; Region: ATP-cone; pfam03477
216597001234	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
216597001235	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
216597001236	catalytic motif [active]
216597001237	Zn binding site [ion binding]; other site
216597001238	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
216597001239	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
216597001240	homopentamer interface [polypeptide binding]; other site
216597001241	active site
216597001242	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
216597001243	putative RNA binding site [nucleotide binding]; other site
216597001244	thiamine monophosphate kinase; Provisional; Region: PRK05731
216597001245	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
216597001246	ATP binding site [chemical binding]; other site
216597001247	dimerization interface [polypeptide binding]; other site
216597001248	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
216597001249	tetramer interfaces [polypeptide binding]; other site
216597001250	binuclear metal-binding site [ion binding]; other site
216597001251	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216597001252	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216597001253	active site
216597001254	catalytic tetrad [active]
216597001255	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
216597001256	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
216597001257	TPP-binding site; other site
216597001258	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
216597001259	PYR/PP interface [polypeptide binding]; other site
216597001260	dimer interface [polypeptide binding]; other site
216597001261	TPP binding site [chemical binding]; other site
216597001262	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
216597001263	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
216597001264	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
216597001265	substrate binding pocket [chemical binding]; other site
216597001266	chain length determination region; other site
216597001267	substrate-Mg2+ binding site; other site
216597001268	catalytic residues [active]
216597001269	aspartate-rich region 1; other site
216597001270	active site lid residues [active]
216597001271	aspartate-rich region 2; other site
216597001272	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
216597001273	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
216597001274	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
216597001275	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
216597001276	Ligand Binding Site [chemical binding]; other site
216597001277	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
216597001278	active site residue [active]
216597001279	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
216597001280	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597001281	dimer interface [polypeptide binding]; other site
216597001282	conserved gate region; other site
216597001283	ABC-ATPase subunit interface; other site
216597001284	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
216597001285	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597001286	dimer interface [polypeptide binding]; other site
216597001287	conserved gate region; other site
216597001288	putative PBP binding loops; other site
216597001289	ABC-ATPase subunit interface; other site
216597001290	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
216597001291	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597001292	Walker A/P-loop; other site
216597001293	ATP binding site [chemical binding]; other site
216597001294	Q-loop/lid; other site
216597001295	ABC transporter signature motif; other site
216597001296	Walker B; other site
216597001297	D-loop; other site
216597001298	H-loop/switch region; other site
216597001299	TOBE domain; Region: TOBE_2; pfam08402
216597001300	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
216597001301	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
216597001302	transcriptional regulator protein; Region: phnR; TIGR03337
216597001303	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597001304	DNA-binding site [nucleotide binding]; DNA binding site
216597001305	UTRA domain; Region: UTRA; pfam07702
216597001306	2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326
216597001307	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216597001308	catalytic residue [active]
216597001309	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
216597001310	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597001311	motif II; other site
216597001312	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
216597001313	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
216597001314	conserved cys residue [active]
216597001315	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
216597001316	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
216597001317	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
216597001318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
216597001319	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
216597001320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597001321	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216597001322	putative substrate translocation pore; other site
216597001324	Sel1-like repeats; Region: SEL1; smart00671
216597001325	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
216597001326	Sel1 repeat; Region: Sel1; pfam08238
216597001327	Sel1-like repeats; Region: SEL1; smart00671
216597001328	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
216597001329	Sel1-like repeats; Region: SEL1; smart00671
216597001330	Sel1-like repeats; Region: SEL1; smart00671
216597001331	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
216597001332	UbiA prenyltransferase family; Region: UbiA; pfam01040
216597001333	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
216597001334	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
216597001335	Subunit III/IV interface [polypeptide binding]; other site
216597001336	Subunit I/III interface [polypeptide binding]; other site
216597001337	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
216597001338	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
216597001339	D-pathway; other site
216597001340	Putative ubiquinol binding site [chemical binding]; other site
216597001341	Low-spin heme (heme b) binding site [chemical binding]; other site
216597001342	Putative water exit pathway; other site
216597001343	Binuclear center (heme o3/CuB) [ion binding]; other site
216597001344	K-pathway; other site
216597001345	Putative proton exit pathway; other site
216597001346	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
216597001347	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
216597001348	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
216597001349	muropeptide transporter; Reviewed; Region: ampG; PRK11902
216597001350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597001351	putative substrate translocation pore; other site
216597001352	hypothetical protein; Provisional; Region: PRK11627
216597001353	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
216597001354	transcriptional regulator BolA; Provisional; Region: PRK11628
216597001355	trigger factor; Provisional; Region: tig; PRK01490
216597001356	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
216597001357	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
216597001358	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
216597001359	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
216597001360	oligomer interface [polypeptide binding]; other site
216597001361	active site residues [active]
216597001362	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
216597001363	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
216597001364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597001365	Walker A motif; other site
216597001366	ATP binding site [chemical binding]; other site
216597001367	Walker B motif; other site
216597001368	Iron permease FTR1 family; Region: FTR1; cl00475
216597001369	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
216597001370	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
216597001371	Found in ATP-dependent protease La (LON); Region: LON; smart00464
216597001372	Found in ATP-dependent protease La (LON); Region: LON; smart00464
216597001373	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597001374	Walker A motif; other site
216597001375	ATP binding site [chemical binding]; other site
216597001376	Walker B motif; other site
216597001377	arginine finger; other site
216597001378	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
216597001379	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
216597001380	IHF dimer interface [polypeptide binding]; other site
216597001381	IHF - DNA interface [nucleotide binding]; other site
216597001382	periplasmic folding chaperone; Provisional; Region: PRK10788
216597001383	SurA N-terminal domain; Region: SurA_N_3; cl07813
216597001384	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
216597001385	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
216597001386	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
216597001387	active site
216597001388	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
216597001389	Ligand Binding Site [chemical binding]; other site
216597001390	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
216597001391	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
216597001392	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
216597001393	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
216597001394	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597001395	active site
216597001396	motif I; other site
216597001397	motif II; other site
216597001398	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
216597001399	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
216597001400	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216597001401	catalytic residue [active]
216597001402	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216597001403	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216597001404	putative DNA binding site [nucleotide binding]; other site
216597001405	putative Zn2+ binding site [ion binding]; other site
216597001406	AsnC family; Region: AsnC_trans_reg; pfam01037
216597001407	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
216597001408	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216597001409	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597001410	Walker A/P-loop; other site
216597001411	ATP binding site [chemical binding]; other site
216597001412	Q-loop/lid; other site
216597001413	ABC transporter signature motif; other site
216597001414	Walker B; other site
216597001415	D-loop; other site
216597001416	H-loop/switch region; other site
216597001417	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
216597001418	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216597001419	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597001420	Walker A/P-loop; other site
216597001421	ATP binding site [chemical binding]; other site
216597001422	Q-loop/lid; other site
216597001423	ABC transporter signature motif; other site
216597001424	Walker B; other site
216597001425	D-loop; other site
216597001426	H-loop/switch region; other site
216597001427	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
216597001428	Nitrogen regulatory protein P-II; Region: P-II; smart00938
216597001429	ammonium transporter; Provisional; Region: PRK10666
216597001430	acyl-CoA thioesterase II; Provisional; Region: PRK10526
216597001431	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
216597001432	active site
216597001433	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
216597001434	catalytic triad [active]
216597001435	dimer interface [polypeptide binding]; other site
216597001436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
216597001437	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
216597001438	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
216597001439	DNA binding site [nucleotide binding]
216597001440	active site
216597001441	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
216597001442	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
216597001443	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597001444	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
216597001445	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
216597001446	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
216597001447	maltose O-acetyltransferase; Provisional; Region: PRK10092
216597001448	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
216597001449	active site
216597001450	substrate binding site [chemical binding]; other site
216597001451	trimer interface [polypeptide binding]; other site
216597001452	CoA binding site [chemical binding]; other site
216597001453	gene expression modulator; Provisional; Region: PRK10945
216597001454	Hha toxicity attenuator; Provisional; Region: PRK10667
216597001455	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
216597001456	Protein export membrane protein; Region: SecD_SecF; cl14618
216597001457	Protein export membrane protein; Region: SecD_SecF; cl14618
216597001458	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
216597001459	HlyD family secretion protein; Region: HlyD_3; pfam13437
216597001460	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
216597001461	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597001462	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
216597001463	hypothetical protein; Provisional; Region: PRK11281
216597001464	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
216597001465	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
216597001466	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216597001467	Uncharacterized conserved protein [Function unknown]; Region: COG5464
216597001468	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
216597001469	hypothetical protein; Provisional; Region: PRK11038
216597001470	primosomal replication protein N''; Provisional; Region: PRK10093
216597001471	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216597001472	active site
216597001473	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
216597001474	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597001475	Walker A motif; other site
216597001476	ATP binding site [chemical binding]; other site
216597001477	Walker B motif; other site
216597001478	DNA polymerase III subunit delta'; Validated; Region: PRK08485
216597001479	arginine finger; other site
216597001480	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
216597001481	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
216597001482	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
216597001483	hypothetical protein; Validated; Region: PRK00153
216597001484	recombination protein RecR; Reviewed; Region: recR; PRK00076
216597001485	RecR protein; Region: RecR; pfam02132
216597001486	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
216597001487	putative active site [active]
216597001488	putative metal-binding site [ion binding]; other site
216597001489	tetramer interface [polypeptide binding]; other site
216597001490	heat shock protein 90; Provisional; Region: PRK05218
216597001491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597001492	ATP binding site [chemical binding]; other site
216597001493	Mg2+ binding site [ion binding]; other site
216597001494	G-X-G motif; other site
216597001495	adenylate kinase; Reviewed; Region: adk; PRK00279
216597001496	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
216597001497	AMP-binding site [chemical binding]; other site
216597001498	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
216597001499	ferrochelatase; Reviewed; Region: hemH; PRK00035
216597001500	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
216597001501	C-terminal domain interface [polypeptide binding]; other site
216597001502	active site
216597001503	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
216597001504	active site
216597001505	N-terminal domain interface [polypeptide binding]; other site
216597001506	acetyl esterase; Provisional; Region: PRK10162
216597001507	inosine/guanosine kinase; Provisional; Region: PRK15074
216597001508	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216597001509	putative cation:proton antiport protein; Provisional; Region: PRK10669
216597001510	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
216597001511	TrkA-N domain; Region: TrkA_N; pfam02254
216597001512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597001513	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216597001514	putative substrate translocation pore; other site
216597001515	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
216597001516	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
216597001517	active site
216597001518	metal binding site [ion binding]; metal-binding site
216597001519	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
216597001520	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
216597001521	putative deacylase active site [active]
216597001522	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
216597001523	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
216597001524	copper exporting ATPase; Provisional; Region: copA; PRK10671
216597001525	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
216597001526	metal-binding site [ion binding]
216597001527	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
216597001528	metal-binding site [ion binding]
216597001529	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216597001530	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597001531	motif II; other site
216597001532	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
216597001533	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
216597001534	DNA binding residues [nucleotide binding]
216597001535	dimer interface [polypeptide binding]; other site
216597001536	copper binding site [ion binding]; other site
216597001537	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
216597001538	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
216597001539	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
216597001540	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
216597001541	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
216597001542	Walker A/P-loop; other site
216597001543	ATP binding site [chemical binding]; other site
216597001544	Q-loop/lid; other site
216597001545	ABC transporter signature motif; other site
216597001546	Walker B; other site
216597001547	D-loop; other site
216597001548	H-loop/switch region; other site
216597001549	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
216597001550	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
216597001551	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
216597001552	oxidoreductase; Provisional; Region: PRK08017
216597001553	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
216597001554	NADP binding site [chemical binding]; other site
216597001555	active site
216597001556	steroid binding site; other site
216597001557	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
216597001558	active site
216597001559	catalytic triad [active]
216597001560	oxyanion hole [active]
216597001561	switch loop; other site
216597001562	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
216597001563	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
216597001564	Walker A/P-loop; other site
216597001565	ATP binding site [chemical binding]; other site
216597001566	Q-loop/lid; other site
216597001567	ABC transporter signature motif; other site
216597001568	Walker B; other site
216597001569	D-loop; other site
216597001570	H-loop/switch region; other site
216597001571	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
216597001572	FtsX-like permease family; Region: FtsX; pfam02687
216597001573	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
216597001574	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
216597001575	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
216597001576	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
216597001577	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
216597001578	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
216597001579	Walker A/P-loop; other site
216597001580	ATP binding site [chemical binding]; other site
216597001581	Q-loop/lid; other site
216597001582	ABC transporter signature motif; other site
216597001583	Walker B; other site
216597001584	D-loop; other site
216597001585	H-loop/switch region; other site
216597001586	NIL domain; Region: NIL; pfam09383
216597001587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597001588	dimer interface [polypeptide binding]; other site
216597001589	conserved gate region; other site
216597001590	ABC-ATPase subunit interface; other site
216597001591	Predicted ATPase [General function prediction only]; Region: COG2603
216597001592	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
216597001593	active site residue [active]
216597001594	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
216597001595	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597001596	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216597001597	dimerization interface [polypeptide binding]; other site
216597001598	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
216597001599	ureidoglycolate hydrolase; Provisional; Region: PRK03606
216597001600	DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163
216597001601	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
216597001602	Bacterial transcriptional regulator; Region: IclR; pfam01614
216597001603	glyoxylate carboligase; Provisional; Region: PRK11269
216597001604	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
216597001605	PYR/PP interface [polypeptide binding]; other site
216597001606	dimer interface [polypeptide binding]; other site
216597001607	TPP binding site [chemical binding]; other site
216597001608	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216597001609	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
216597001610	TPP-binding site [chemical binding]; other site
216597001611	hydroxypyruvate isomerase; Provisional; Region: PRK09997
216597001612	tartronate semialdehyde reductase; Provisional; Region: PRK15059
216597001613	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
216597001614	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597001615	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216597001616	putative substrate translocation pore; other site
216597001617	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
216597001618	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
216597001619	Na binding site [ion binding]; other site
216597001620	putative substrate binding site [chemical binding]; other site
216597001621	allantoinase; Provisional; Region: PRK08044
216597001622	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
216597001623	active site
216597001624	putative uracil/xanthine transporter; Provisional; Region: PRK11412
216597001625	glycerate kinase II; Provisional; Region: PRK09932
216597001626	Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257
216597001627	Mif2/CENP-C like; Region: Mif2; pfam11699
216597001628	Cupin domain; Region: Cupin_2; pfam07883
216597001629	allantoate amidohydrolase; Region: AllC; TIGR03176
216597001630	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
216597001631	active site
216597001632	metal binding site [ion binding]; metal-binding site
216597001633	dimer interface [polypeptide binding]; other site
216597001634	ureidoglycolate dehydrogenase; Provisional; Region: PRK15025
216597001635	membrane protein FdrA; Validated; Region: PRK06091
216597001636	CoA binding domain; Region: CoA_binding; pfam02629
216597001637	CoA-ligase; Region: Ligase_CoA; pfam00549
216597001638	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
216597001639	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
216597001640	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
216597001641	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
216597001642	putative substrate binding site [chemical binding]; other site
216597001643	nucleotide binding site [chemical binding]; other site
216597001644	nucleotide binding site [chemical binding]; other site
216597001645	homodimer interface [polypeptide binding]; other site
216597001646	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
216597001647	ATP-grasp domain; Region: ATP-grasp; pfam02222
216597001648	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
216597001649	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
216597001650	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
216597001651	putative active site [active]
216597001652	putative metal binding site [ion binding]; other site
216597001653	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
216597001654	substrate binding site [chemical binding]; other site
216597001655	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
216597001656	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
216597001657	active site
216597001658	HIGH motif; other site
216597001659	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
216597001660	KMSKS motif; other site
216597001661	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
216597001662	tRNA binding surface [nucleotide binding]; other site
216597001663	anticodon binding site; other site
216597001664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
216597001665	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
216597001666	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
216597001667	ribosome-associated protein; Provisional; Region: PRK11507
216597001668	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
216597001669	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
216597001670	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
216597001671	homodimer interface [polypeptide binding]; other site
216597001672	NADP binding site [chemical binding]; other site
216597001673	substrate binding site [chemical binding]; other site
216597001674	type-1 fimbrial protein subunit A; Provisional; Region: PRK15194
216597001675	fimbrial protein FimI; Provisional; Region: PRK15200
216597001676	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
216597001677	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597001678	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597001679	outer membrane usher protein FimD; Provisional; Region: PRK15198
216597001680	PapC N-terminal domain; Region: PapC_N; pfam13954
216597001681	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216597001682	PapC C-terminal domain; Region: PapC_C; pfam13953
216597001683	fimbrial-like adhesin; Provisional; Region: fimH; PRK15199
216597001684	fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934
216597001685	transcriptional regulator FimZ; Provisional; Region: PRK09935
216597001686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597001687	active site
216597001688	phosphorylation site [posttranslational modification]
216597001689	intermolecular recognition site; other site
216597001690	dimerization interface [polypeptide binding]; other site
216597001691	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597001692	DNA binding residues [nucleotide binding]
216597001693	dimerization interface [polypeptide binding]; other site
216597001694	fimbriae regulatory protein FimW; Provisional; Region: PRK15201
216597001695	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597001696	DNA binding residues [nucleotide binding]
216597001697	dimerization interface [polypeptide binding]; other site
216597001699	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
216597001700	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
216597001701	Ligand binding site; other site
216597001702	Putative Catalytic site; other site
216597001703	DXD motif; other site
216597001704	Predicted membrane protein [Function unknown]; Region: COG2246
216597001705	GtrA-like protein; Region: GtrA; pfam04138
216597001708	Cupin; Region: Cupin_6; pfam12852
216597001709	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216597001710	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597001711	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597001712	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
216597001713	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216597001714	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
216597001715	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
216597001716	Predicted membrane protein [Function unknown]; Region: COG3059
216597001717	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
216597001718	phenylalanine transporter; Provisional; Region: PRK10249
216597001719	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
216597001720	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216597001721	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
216597001722	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
216597001723	active site
216597001724	oxyanion hole [active]
216597001725	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
216597001726	catalytic triad [active]
216597001727	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
216597001728	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
216597001729	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597001730	ATP binding site [chemical binding]; other site
216597001731	Walker B motif; other site
216597001732	arginine finger; other site
216597001733	Transcriptional antiterminator [Transcription]; Region: COG3933
216597001734	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
216597001735	active pocket/dimerization site; other site
216597001736	active site
216597001737	phosphorylation site [posttranslational modification]
216597001738	PRD domain; Region: PRD; pfam00874
216597001739	absent from CT18
216597001740	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
216597001741	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
216597001742	putative active site [active]
216597001743	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
216597001744	dimer interface [polypeptide binding]; other site
216597001745	active site
216597001746	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
216597001747	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
216597001748	dimer interface [polypeptide binding]; other site
216597001749	active site
216597001750	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
216597001751	dimer interface [polypeptide binding]; other site
216597001752	active site
216597001753	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
216597001754	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
216597001755	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
216597001756	active site
216597001757	phosphorylation site [posttranslational modification]
216597001758	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
216597001759	active pocket/dimerization site; other site
216597001760	active site
216597001761	phosphorylation site [posttranslational modification]
216597001762	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
216597001763	dimer interface [polypeptide binding]; other site
216597001764	FMN binding site [chemical binding]; other site
216597001765	hypothetical protein; Provisional; Region: PRK10250
216597001766	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216597001767	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597001768	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
216597001769	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597001770	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
216597001771	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
216597001772	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
216597001773	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
216597001774	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
216597001775	outer membrane receptor FepA; Provisional; Region: PRK13524
216597001776	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216597001777	N-terminal plug; other site
216597001778	ligand-binding site [chemical binding]; other site
216597001779	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
216597001780	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
216597001781	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
216597001782	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
216597001783	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
216597001784	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216597001785	acyl-activating enzyme (AAE) consensus motif; other site
216597001786	AMP binding site [chemical binding]; other site
216597001787	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216597001788	LPS O-antigen length regulator; Provisional; Region: PRK10381
216597001789	Chain length determinant protein; Region: Wzz; pfam02706
216597001790	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
216597001791	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
216597001792	Walker A/P-loop; other site
216597001793	ATP binding site [chemical binding]; other site
216597001794	Q-loop/lid; other site
216597001795	ABC transporter signature motif; other site
216597001796	Walker B; other site
216597001797	D-loop; other site
216597001798	H-loop/switch region; other site
216597001799	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
216597001800	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216597001801	ABC-ATPase subunit  interface; other site
216597001802	dimer interface [polypeptide binding]; other site
216597001803	putative PBP binding regions; other site
216597001804	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
216597001805	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216597001806	ABC-ATPase subunit  interface; other site
216597001807	dimer interface [polypeptide binding]; other site
216597001808	putative PBP binding regions; other site
216597001809	enterobactin exporter EntS; Provisional; Region: PRK10489
216597001810	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597001811	putative substrate translocation pore; other site
216597001812	ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592
216597001813	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
216597001814	siderophore binding site; other site
216597001815	isochorismate synthase EntC; Provisional; Region: PRK15016
216597001816	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
216597001817	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
216597001818	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
216597001819	acyl-activating enzyme (AAE) consensus motif; other site
216597001820	active site
216597001821	AMP binding site [chemical binding]; other site
216597001822	substrate binding site [chemical binding]; other site
216597001823	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
216597001824	hydrophobic substrate binding pocket; other site
216597001825	Isochorismatase family; Region: Isochorismatase; pfam00857
216597001826	active site
216597001827	conserved cis-peptide bond; other site
216597001828	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
216597001829	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
216597001830	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
216597001831	putative NAD(P) binding site [chemical binding]; other site
216597001832	active site
216597001833	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
216597001834	CoenzymeA binding site [chemical binding]; other site
216597001835	subunit interaction site [polypeptide binding]; other site
216597001836	PHB binding site; other site
216597001837	carbon starvation protein A; Provisional; Region: PRK15015
216597001838	Carbon starvation protein CstA; Region: CstA; pfam02554
216597001839	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
216597001840	Uncharacterized small protein [Function unknown]; Region: COG2879
216597001841	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
216597001842	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
216597001843	putative active site [active]
216597001844	metal binding site [ion binding]; metal-binding site
216597001845	methionine aminotransferase; Validated; Region: PRK09082
216597001846	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216597001847	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597001848	homodimer interface [polypeptide binding]; other site
216597001849	catalytic residue [active]
216597001850	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
216597001851	ParB-like nuclease domain; Region: ParBc; pfam02195
216597001852	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
216597001853	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
216597001854	Active Sites [active]
216597001855	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
216597001856	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
216597001857	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597001858	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216597001859	dimerization interface [polypeptide binding]; other site
216597001860	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
216597001861	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
216597001862	dimerization domain [polypeptide binding]; other site
216597001863	dimer interface [polypeptide binding]; other site
216597001864	catalytic residues [active]
216597001865	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
216597001866	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
216597001867	dimer interface [polypeptide binding]; other site
216597001868	decamer (pentamer of dimers) interface [polypeptide binding]; other site
216597001869	catalytic triad [active]
216597001870	peroxidatic and resolving cysteines [active]
216597001871	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
216597001872	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
216597001873	catalytic residue [active]
216597001874	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
216597001875	catalytic residues [active]
216597001876	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216597001877	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216597001878	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
216597001879	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
216597001880	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
216597001881	putative [4Fe-4S] binding site [ion binding]; other site
216597001882	putative molybdopterin cofactor binding site [chemical binding]; other site
216597001883	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
216597001884	molybdopterin cofactor binding site; other site
216597001885	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
216597001886	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
216597001887	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
216597001888	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216597001889	Ligand Binding Site [chemical binding]; other site
216597001890	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
216597001891	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
216597001892	NAD binding site [chemical binding]; other site
216597001893	catalytic Zn binding site [ion binding]; other site
216597001894	structural Zn binding site [ion binding]; other site
216597001895	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
216597001896	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
216597001897	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
216597001898	B1 nucleotide binding pocket [chemical binding]; other site
216597001899	B2 nucleotide binding pocket [chemical binding]; other site
216597001900	CAS motifs; other site
216597001901	active site
216597001902	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
216597001903	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
216597001904	transmembrane helices; other site
216597001905	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
216597001906	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
216597001907	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
216597001908	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
216597001909	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
216597001910	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
216597001911	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
216597001912	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
216597001913	putative active site [active]
216597001914	(T/H)XGH motif; other site
216597001915	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
216597001916	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216597001917	putative active site [active]
216597001918	heme pocket [chemical binding]; other site
216597001919	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597001920	ATP binding site [chemical binding]; other site
216597001921	Mg2+ binding site [ion binding]; other site
216597001922	G-X-G motif; other site
216597001923	two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046
216597001924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597001925	active site
216597001926	phosphorylation site [posttranslational modification]
216597001927	intermolecular recognition site; other site
216597001928	dimerization interface [polypeptide binding]; other site
216597001929	Transcriptional regulator; Region: CitT; pfam12431
216597001930	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
216597001931	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
216597001932	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
216597001933	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
216597001934	DNA-binding site [nucleotide binding]; DNA binding site
216597001935	RNA-binding motif; other site
216597001936	chromosome condensation membrane protein; Provisional; Region: PRK14196
216597001937	Predicted amidohydrolase [General function prediction only]; Region: COG0388
216597001938	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
216597001939	putative active site [active]
216597001940	catalytic triad [active]
216597001941	putative dimer interface [polypeptide binding]; other site
216597001942	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
216597001943	lipoyl synthase; Provisional; Region: PRK05481
216597001944	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597001945	FeS/SAM binding site; other site
216597001946	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
216597001947	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597001948	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
216597001949	substrate binding pocket [chemical binding]; other site
216597001950	dimerization interface [polypeptide binding]; other site
216597001951	lipoate-protein ligase B; Provisional; Region: PRK14342
216597001952	hypothetical protein; Provisional; Region: PRK04998
216597001953	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
216597001954	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
216597001955	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
216597001956	rare lipoprotein A; Provisional; Region: PRK10672
216597001957	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
216597001958	Sporulation related domain; Region: SPOR; pfam05036
216597001959	cell wall shape-determining protein; Provisional; Region: PRK10794
216597001960	penicillin-binding protein 2; Provisional; Region: PRK10795
216597001961	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
216597001962	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
216597001963	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
216597001964	ribosome-associated protein; Provisional; Region: PRK11538
216597001965	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
216597001966	catalytic core [active]
216597001967	threonine-phosphate decarboxylase; Provisional; Region: PRK08056
216597001968	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216597001969	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597001970	homodimer interface [polypeptide binding]; other site
216597001971	catalytic residue [active]
216597001972	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
216597001973	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
216597001974	active site
216597001975	(T/H)XGH motif; other site
216597001976	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
216597001977	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
216597001978	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
216597001979	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
216597001980	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
216597001981	HIGH motif; other site
216597001982	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
216597001983	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
216597001984	active site
216597001985	KMSKS motif; other site
216597001986	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
216597001987	tRNA binding surface [nucleotide binding]; other site
216597001988	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
216597001989	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
216597001990	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
216597001991	Propionate catabolism activator; Region: PrpR_N; pfam06506
216597001992	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
216597001993	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597001994	Walker A motif; other site
216597001995	ATP binding site [chemical binding]; other site
216597001996	Walker B motif; other site
216597001997	arginine finger; other site
216597001998	hypothetical protein; Provisional; Region: PRK11032
216597001999	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
216597002000	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
216597002001	Sel1-like repeats; Region: SEL1; smart00671
216597002002	Sel1-like repeats; Region: SEL1; smart00671
216597002003	Sel1-like repeats; Region: SEL1; smart00671
216597002004	Sel1-like repeats; Region: SEL1; smart00671
216597002005	Sel1-like repeats; Region: SEL1; smart00671
216597002006	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
216597002007	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
216597002008	HSP70 interaction site [polypeptide binding]; other site
216597002009	Note the frameshift mutation following codon 46
216597002010	DnaJ domain; Region: DnaJ; pfam00226
216597002011	HSP70 interaction site [polypeptide binding]; other site
216597002012	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
216597002013	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
216597002014	nucleotide binding site [chemical binding]; other site
216597002015	putative NEF/HSP70 interaction site [polypeptide binding]; other site
216597002016	SBD interface [polypeptide binding]; other site
216597002017	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
216597002018	active site
216597002019	tetramer interface [polypeptide binding]; other site
216597002020	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216597002021	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216597002022	Walker A/P-loop; other site
216597002023	ATP binding site [chemical binding]; other site
216597002024	Q-loop/lid; other site
216597002025	ABC transporter signature motif; other site
216597002026	Walker B; other site
216597002027	D-loop; other site
216597002028	H-loop/switch region; other site
216597002029	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216597002030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597002031	dimer interface [polypeptide binding]; other site
216597002032	conserved gate region; other site
216597002033	putative PBP binding loops; other site
216597002034	ABC-ATPase subunit interface; other site
216597002035	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216597002036	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597002037	dimer interface [polypeptide binding]; other site
216597002038	conserved gate region; other site
216597002039	putative PBP binding loops; other site
216597002040	ABC-ATPase subunit interface; other site
216597002041	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
216597002042	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597002043	substrate binding pocket [chemical binding]; other site
216597002044	membrane-bound complex binding site; other site
216597002045	hinge residues; other site
216597002046	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
216597002047	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
216597002048	putative active site [active]
216597002049	catalytic triad [active]
216597002050	putative dimer interface [polypeptide binding]; other site
216597002051	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
216597002052	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
216597002053	Transporter associated domain; Region: CorC_HlyC; smart01091
216597002054	metal-binding heat shock protein; Provisional; Region: PRK00016
216597002055	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
216597002056	PhoH-like protein; Region: PhoH; pfam02562
216597002057	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
216597002058	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
216597002059	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597002060	FeS/SAM binding site; other site
216597002061	TRAM domain; Region: TRAM; pfam01938
216597002062	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
216597002063	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
216597002064	asparagine synthetase B; Provisional; Region: asnB; PRK09431
216597002065	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
216597002066	active site
216597002067	dimer interface [polypeptide binding]; other site
216597002068	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
216597002069	Ligand Binding Site [chemical binding]; other site
216597002070	Molecular Tunnel; other site
216597002071	UMP phosphatase; Provisional; Region: PRK10444
216597002072	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597002073	active site
216597002074	motif I; other site
216597002075	motif II; other site
216597002076	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597002077	MarR family; Region: MarR; pfam01047
216597002078	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
216597002079	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
216597002080	nucleotide binding site [chemical binding]; other site
216597002081	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
216597002082	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
216597002083	active site
216597002084	dimer interface [polypeptide binding]; other site
216597002085	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
216597002086	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
216597002087	active site
216597002088	trimer interface [polypeptide binding]; other site
216597002089	allosteric site; other site
216597002090	active site lid [active]
216597002091	hexamer (dimer of trimers) interface [polypeptide binding]; other site
216597002092	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
216597002093	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
216597002094	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
216597002095	active site turn [active]
216597002096	phosphorylation site [posttranslational modification]
216597002097	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
216597002098	HPr interaction site; other site
216597002099	glycerol kinase (GK) interaction site [polypeptide binding]; other site
216597002100	active site
216597002101	phosphorylation site [posttranslational modification]
216597002102	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
216597002103	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
216597002104	active site
216597002105	HIGH motif; other site
216597002106	nucleotide binding site [chemical binding]; other site
216597002107	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
216597002108	KMSKS motif; other site
216597002109	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
216597002110	outer membrane porin, OprD family; Region: OprD; pfam03573
216597002111	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
216597002112	YbfN-like lipoprotein; Region: YbfN; pfam13982
216597002113	citrate-proton symporter; Provisional; Region: PRK15075
216597002114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597002115	putative substrate translocation pore; other site
216597002116	tricarballylate utilization protein B; Provisional; Region: PRK15033
216597002117	tricarballylate dehydrogenase; Validated; Region: PRK08274
216597002118	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216597002119	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597002120	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597002121	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
216597002122	putative dimerization interface [polypeptide binding]; other site
216597002123	ferric uptake regulator; Provisional; Region: fur; PRK09462
216597002124	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
216597002125	metal binding site 2 [ion binding]; metal-binding site
216597002126	putative DNA binding helix; other site
216597002127	metal binding site 1 [ion binding]; metal-binding site
216597002128	dimer interface [polypeptide binding]; other site
216597002129	structural Zn2+ binding site [ion binding]; other site
216597002130	flavodoxin FldA; Validated; Region: PRK09267
216597002131	LexA regulated protein; Provisional; Region: PRK11675
216597002132	acyl-CoA esterase; Provisional; Region: PRK10673
216597002133	PGAP1-like protein; Region: PGAP1; pfam07819
216597002134	replication initiation regulator SeqA; Provisional; Region: PRK11187
216597002135	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
216597002136	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
216597002137	active site
216597002138	substrate binding site [chemical binding]; other site
216597002139	metal binding site [ion binding]; metal-binding site
216597002140	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
216597002141	putrescine transporter; Provisional; Region: potE; PRK10655
216597002142	ornithine decarboxylase; Provisional; Region: PRK13578
216597002143	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
216597002144	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
216597002145	homodimer interface [polypeptide binding]; other site
216597002146	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597002147	catalytic residue [active]
216597002148	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
216597002149	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
216597002150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597002151	active site
216597002152	phosphorylation site [posttranslational modification]
216597002153	intermolecular recognition site; other site
216597002154	dimerization interface [polypeptide binding]; other site
216597002155	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597002156	DNA binding site [nucleotide binding]
216597002157	sensor protein KdpD; Provisional; Region: PRK10490
216597002158	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
216597002159	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
216597002160	Ligand Binding Site [chemical binding]; other site
216597002161	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
216597002162	GAF domain; Region: GAF_3; pfam13492
216597002163	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597002164	dimer interface [polypeptide binding]; other site
216597002165	phosphorylation site [posttranslational modification]
216597002166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597002167	ATP binding site [chemical binding]; other site
216597002168	Mg2+ binding site [ion binding]; other site
216597002169	G-X-G motif; other site
216597002170	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
216597002171	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
216597002172	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216597002173	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
216597002174	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
216597002175	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
216597002176	DNA photolyase; Region: DNA_photolyase; pfam00875
216597002177	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
216597002178	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597002179	putative substrate translocation pore; other site
216597002180	POT family; Region: PTR2; pfam00854
216597002181	Uncharacterized conserved protein [Function unknown]; Region: COG0327
216597002182	metal-binding protein; Provisional; Region: PRK10799
216597002183	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
216597002184	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
216597002185	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
216597002186	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
216597002187	putative active site [active]
216597002188	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216597002189	active site
216597002190	DNA binding site [nucleotide binding]
216597002191	Int/Topo IB signature motif; other site
216597002192	Note the premature stop codon following codon 159
216597002193	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
216597002194	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216597002195	active site
216597002196	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
216597002197	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216597002198	putative ADP-binding pocket [chemical binding]; other site
216597002199	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
216597002200	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
216597002201	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
216597002202	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
216597002203	Walker A/P-loop; other site
216597002204	ATP binding site [chemical binding]; other site
216597002205	Q-loop/lid; other site
216597002206	ABC transporter signature motif; other site
216597002207	Walker B; other site
216597002208	D-loop; other site
216597002209	H-loop/switch region; other site
216597002210	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
216597002211	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216597002212	active site
216597002213	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
216597002214	active site
216597002215	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
216597002216	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
216597002217	endonuclease VIII; Provisional; Region: PRK10445
216597002218	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
216597002219	DNA binding site [nucleotide binding]
216597002220	catalytic residue [active]
216597002221	putative catalytic residues [active]
216597002222	H2TH interface [polypeptide binding]; other site
216597002223	intercalation triad [nucleotide binding]; other site
216597002224	substrate specificity determining residue; other site
216597002225	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
216597002226	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
216597002227	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
216597002228	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
216597002229	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
216597002230	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
216597002231	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
216597002232	dimer interface [polypeptide binding]; other site
216597002233	active site
216597002234	citrylCoA binding site [chemical binding]; other site
216597002235	NADH binding [chemical binding]; other site
216597002236	cationic pore residues; other site
216597002237	oxalacetate/citrate binding site [chemical binding]; other site
216597002238	coenzyme A binding site [chemical binding]; other site
216597002239	catalytic triad [active]
216597002240	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
216597002241	Iron-sulfur protein interface; other site
216597002242	proximal quinone binding site [chemical binding]; other site
216597002243	SdhD (CybS) interface [polypeptide binding]; other site
216597002244	proximal heme binding site [chemical binding]; other site
216597002245	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
216597002246	SdhC subunit interface [polypeptide binding]; other site
216597002247	proximal heme binding site [chemical binding]; other site
216597002248	cardiolipin binding site; other site
216597002249	Iron-sulfur protein interface; other site
216597002250	proximal quinone binding site [chemical binding]; other site
216597002251	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
216597002252	L-aspartate oxidase; Provisional; Region: PRK06175
216597002253	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
216597002254	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
216597002255	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
216597002256	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
216597002257	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
216597002258	TPP-binding site [chemical binding]; other site
216597002259	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
216597002260	dimer interface [polypeptide binding]; other site
216597002261	PYR/PP interface [polypeptide binding]; other site
216597002262	TPP binding site [chemical binding]; other site
216597002263	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
216597002264	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
216597002265	E3 interaction surface; other site
216597002266	lipoyl attachment site [posttranslational modification]; other site
216597002267	e3 binding domain; Region: E3_binding; pfam02817
216597002268	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
216597002269	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
216597002270	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
216597002271	CoA-ligase; Region: Ligase_CoA; pfam00549
216597002272	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
216597002273	CoA binding domain; Region: CoA_binding; smart00881
216597002274	CoA-ligase; Region: Ligase_CoA; pfam00549
216597002275	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
216597002276	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
216597002277	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
216597002278	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
216597002279	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
216597002280	hypothetical protein; Provisional; Region: PRK10588
216597002281	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
216597002282	active site
216597002283	colicin uptake protein TolQ; Provisional; Region: PRK10801
216597002284	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
216597002285	colicin uptake protein TolR; Provisional; Region: PRK11024
216597002286	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
216597002287	TolA C-terminal; Region: TolA; pfam06519
216597002288	translocation protein TolB; Provisional; Region: tolB; PRK03629
216597002289	TolB amino-terminal domain; Region: TolB_N; pfam04052
216597002290	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
216597002291	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
216597002292	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
216597002293	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
216597002294	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216597002295	ligand binding site [chemical binding]; other site
216597002296	tol-pal system protein YbgF; Provisional; Region: PRK10803
216597002297	Tetratricopeptide repeat; Region: TPR_6; pfam13174
216597002298	Tetratricopeptide repeat; Region: TPR_6; pfam13174
216597002299	quinolinate synthetase; Provisional; Region: PRK09375
216597002300	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
216597002301	zinc transporter ZitB; Provisional; Region: PRK03557
216597002302	YbgS-like protein; Region: YbgS; pfam13985
216597002303	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
216597002304	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
216597002305	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
216597002306	fumarate hydratase; Provisional; Region: PRK06246
216597002307	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597002308	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597002309	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216597002310	dimerization interface [polypeptide binding]; other site
216597002311	cell density-dependent motility repressor; Provisional; Region: PRK10082
216597002312	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597002313	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216597002314	dimerization interface [polypeptide binding]; other site
216597002315	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
216597002316	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
216597002317	transmembrane helices; other site
216597002318	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
216597002319	oxaloacetate decarboxylase; Provisional; Region: PRK14040
216597002320	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
216597002321	active site
216597002322	catalytic residues [active]
216597002323	metal binding site [ion binding]; metal-binding site
216597002324	homodimer binding site [polypeptide binding]; other site
216597002325	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
216597002326	carboxyltransferase (CT) interaction site; other site
216597002327	biotinylation site [posttranslational modification]; other site
216597002328	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
216597002329	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
216597002330	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
216597002331	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216597002332	dimer interface [polypeptide binding]; other site
216597002333	putative PBP binding regions; other site
216597002334	ABC-ATPase subunit  interface; other site
216597002335	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
216597002336	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
216597002337	Walker A/P-loop; other site
216597002338	ATP binding site [chemical binding]; other site
216597002339	Q-loop/lid; other site
216597002340	ABC transporter signature motif; other site
216597002341	Walker B; other site
216597002342	D-loop; other site
216597002343	H-loop/switch region; other site
216597002344	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
216597002345	catalytic core [active]
216597002346	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
216597002347	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
216597002348	active site
216597002349	catalytic residues [active]
216597002350	galactokinase; Provisional; Region: PRK05101
216597002351	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
216597002352	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
216597002353	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
216597002354	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
216597002355	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
216597002356	dimer interface [polypeptide binding]; other site
216597002357	active site
216597002358	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
216597002359	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
216597002360	NAD binding site [chemical binding]; other site
216597002361	homodimer interface [polypeptide binding]; other site
216597002362	active site
216597002363	substrate binding site [chemical binding]; other site
216597002364	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714
216597002365	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
216597002366	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597002367	Walker A/P-loop; other site
216597002368	ATP binding site [chemical binding]; other site
216597002369	Q-loop/lid; other site
216597002370	ABC transporter signature motif; other site
216597002371	Walker B; other site
216597002372	D-loop; other site
216597002373	H-loop/switch region; other site
216597002374	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597002375	Walker A/P-loop; other site
216597002376	ATP binding site [chemical binding]; other site
216597002377	Q-loop/lid; other site
216597002378	ABC transporter signature motif; other site
216597002379	Walker B; other site
216597002380	D-loop; other site
216597002381	H-loop/switch region; other site
216597002382	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
216597002383	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
216597002384	molybdenum-pterin binding domain; Region: Mop; TIGR00638
216597002385	TOBE domain; Region: TOBE; pfam03459
216597002386	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
216597002387	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
216597002388	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597002389	substrate binding pocket [chemical binding]; other site
216597002390	membrane-bound complex binding site; other site
216597002391	hinge residues; other site
216597002392	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
216597002393	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597002394	dimer interface [polypeptide binding]; other site
216597002395	conserved gate region; other site
216597002396	putative PBP binding loops; other site
216597002397	ABC-ATPase subunit interface; other site
216597002398	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
216597002399	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597002400	Walker A/P-loop; other site
216597002401	ATP binding site [chemical binding]; other site
216597002402	Q-loop/lid; other site
216597002403	ABC transporter signature motif; other site
216597002404	Walker B; other site
216597002405	D-loop; other site
216597002406	H-loop/switch region; other site
216597002407	molybdenum-pterin binding domain; Region: Mop; TIGR00638
216597002408	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
216597002409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597002410	active site
216597002411	motif I; other site
216597002412	motif II; other site
216597002413	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597002414	6-phosphogluconolactonase; Provisional; Region: PRK11028
216597002415	acyl-CoA thioesterase; Provisional; Region: PRK10531
216597002416	putative pectinesterase; Region: PLN02432; cl01911
216597002417	imidazolonepropionase; Validated; Region: PRK09356
216597002418	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
216597002419	active site
216597002420	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
216597002421	putative active site [active]
216597002422	putative metal binding site [ion binding]; other site
216597002423	histidine utilization repressor; Provisional; Region: PRK14999
216597002424	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597002425	DNA-binding site [nucleotide binding]; DNA binding site
216597002426	UTRA domain; Region: UTRA; pfam07702
216597002427	urocanate hydratase; Provisional; Region: PRK05414
216597002428	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
216597002429	active sites [active]
216597002430	tetramer interface [polypeptide binding]; other site
216597002431	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
216597002432	substrate binding site [chemical binding]; other site
216597002433	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
216597002434	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216597002435	inhibitor-cofactor binding pocket; inhibition site
216597002436	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597002437	catalytic residue [active]
216597002438	biotin synthase; Provisional; Region: PRK15108
216597002439	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597002440	FeS/SAM binding site; other site
216597002441	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
216597002442	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
216597002443	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
216597002444	substrate-cofactor binding pocket; other site
216597002445	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597002446	catalytic residue [active]
216597002447	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
216597002448	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597002449	S-adenosylmethionine binding site [chemical binding]; other site
216597002450	AAA domain; Region: AAA_26; pfam13500
216597002451	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
216597002452	excinuclease ABC subunit B; Provisional; Region: PRK05298
216597002453	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216597002454	ATP binding site [chemical binding]; other site
216597002455	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597002456	nucleotide binding region [chemical binding]; other site
216597002457	ATP-binding site [chemical binding]; other site
216597002458	Ultra-violet resistance protein B; Region: UvrB; pfam12344
216597002459	UvrB/uvrC motif; Region: UVR; pfam02151
216597002460	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
216597002461	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
216597002462	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
216597002463	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
216597002464	Leucine-rich repeats; other site
216597002465	Substrate binding site [chemical binding]; other site
216597002466	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
216597002467	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
216597002468	putative substrate binding pocket [chemical binding]; other site
216597002469	dimer interface [polypeptide binding]; other site
216597002470	phosphate binding site [ion binding]; other site
216597002471	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
216597002472	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597002473	FeS/SAM binding site; other site
216597002474	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
216597002475	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
216597002476	MPT binding site; other site
216597002477	trimer interface [polypeptide binding]; other site
216597002478	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
216597002479	trimer interface [polypeptide binding]; other site
216597002480	dimer interface [polypeptide binding]; other site
216597002481	putative active site [active]
216597002482	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
216597002483	MoaE interaction surface [polypeptide binding]; other site
216597002484	MoeB interaction surface [polypeptide binding]; other site
216597002485	thiocarboxylated glycine; other site
216597002486	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
216597002487	MoaE homodimer interface [polypeptide binding]; other site
216597002488	MoaD interaction [polypeptide binding]; other site
216597002489	active site residues [active]
216597002490	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
216597002491	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
216597002492	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
216597002493	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
216597002494	Predicted integral membrane protein [Function unknown]; Region: COG0392
216597002495	cardiolipin synthase 2; Provisional; Region: PRK11263
216597002496	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
216597002497	putative active site [active]
216597002498	catalytic site [active]
216597002499	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
216597002500	putative active site [active]
216597002501	catalytic site [active]
216597002502	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
216597002503	putative catalytic site [active]
216597002504	putative metal binding site [ion binding]; other site
216597002505	putative phosphate binding site [ion binding]; other site
216597002506	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
216597002507	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
216597002508	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
216597002509	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
216597002510	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
216597002511	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
216597002512	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
216597002513	Walker A/P-loop; other site
216597002514	ATP binding site [chemical binding]; other site
216597002515	Q-loop/lid; other site
216597002516	ABC transporter signature motif; other site
216597002517	Walker B; other site
216597002518	D-loop; other site
216597002519	H-loop/switch region; other site
216597002520	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
216597002521	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
216597002522	Walker A/P-loop; other site
216597002523	ATP binding site [chemical binding]; other site
216597002524	Q-loop/lid; other site
216597002525	ABC transporter signature motif; other site
216597002526	Walker B; other site
216597002527	D-loop; other site
216597002528	H-loop/switch region; other site
216597002529	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
216597002530	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
216597002531	HlyD family secretion protein; Region: HlyD_3; pfam13437
216597002532	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
216597002533	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597002534	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
216597002535	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
216597002536	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
216597002537	ATP binding site [chemical binding]; other site
216597002538	Mg++ binding site [ion binding]; other site
216597002539	motif III; other site
216597002540	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597002541	nucleotide binding region [chemical binding]; other site
216597002542	ATP-binding site [chemical binding]; other site
216597002543	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
216597002544	DEAD_2; Region: DEAD_2; pfam06733
216597002545	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
216597002546	glycosyl transferase family protein; Provisional; Region: PRK08136
216597002547	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
216597002548	hypothetical protein; Provisional; Region: PRK10259
216597002549	hypothetical protein; Provisional; Region: PRK11019
216597002550	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
216597002551	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
216597002552	putative mechanosensitive channel protein; Provisional; Region: PRK11465
216597002553	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216597002554	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
216597002555	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216597002556	Walker A/P-loop; other site
216597002557	ATP binding site [chemical binding]; other site
216597002558	Q-loop/lid; other site
216597002559	ABC transporter signature motif; other site
216597002560	Walker B; other site
216597002561	D-loop; other site
216597002562	H-loop/switch region; other site
216597002563	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216597002564	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597002565	dimer interface [polypeptide binding]; other site
216597002566	conserved gate region; other site
216597002567	putative PBP binding loops; other site
216597002568	ABC-ATPase subunit interface; other site
216597002569	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
216597002570	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597002571	substrate binding pocket [chemical binding]; other site
216597002572	membrane-bound complex binding site; other site
216597002573	hinge residues; other site
216597002574	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
216597002575	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
216597002576	dimerization interface [polypeptide binding]; other site
216597002577	DPS ferroxidase diiron center [ion binding]; other site
216597002578	ion pore; other site
216597002579	threonine and homoserine efflux system; Provisional; Region: PRK10532
216597002580	EamA-like transporter family; Region: EamA; pfam00892
216597002581	outer membrane protein X; Provisional; Region: ompX; PRK09408
216597002582	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
216597002583	Sulfatase; Region: Sulfatase; pfam00884
216597002584	manganese transport regulator MntR; Provisional; Region: PRK11050
216597002585	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
216597002586	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
216597002587	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
216597002588	transmembrane helices; other site
216597002589	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
216597002590	L,D-transpeptidase; Provisional; Region: PRK10260
216597002591	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
216597002592	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
216597002593	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216597002594	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597002595	Walker A/P-loop; other site
216597002596	ATP binding site [chemical binding]; other site
216597002597	ABC transporter signature motif; other site
216597002598	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216597002599	Walker B; other site
216597002600	ABC transporter; Region: ABC_tran_2; pfam12848
216597002601	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216597002602	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
216597002603	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597002604	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
216597002605	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
216597002606	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597002607	active site
216597002608	motif I; other site
216597002609	motif II; other site
216597002610	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597002611	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
216597002612	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
216597002613	dimer interface [polypeptide binding]; other site
216597002614	active site
216597002615	glycine loop; other site
216597002616	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
216597002617	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597002618	FeS/SAM binding site; other site
216597002619	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
216597002620	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
216597002621	ATP binding site [chemical binding]; other site
216597002622	substrate interface [chemical binding]; other site
216597002623	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
216597002624	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
216597002625	dimer interface [polypeptide binding]; other site
216597002626	putative functional site; other site
216597002627	putative MPT binding site; other site
216597002628	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
216597002629	catalytic nucleophile [active]
216597002630	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
216597002631	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216597002632	Walker A/P-loop; other site
216597002633	ATP binding site [chemical binding]; other site
216597002634	Q-loop/lid; other site
216597002635	ABC transporter signature motif; other site
216597002636	Walker B; other site
216597002637	D-loop; other site
216597002638	H-loop/switch region; other site
216597002639	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216597002640	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216597002641	Walker A/P-loop; other site
216597002642	ATP binding site [chemical binding]; other site
216597002643	Q-loop/lid; other site
216597002644	ABC transporter signature motif; other site
216597002645	Walker B; other site
216597002646	D-loop; other site
216597002647	H-loop/switch region; other site
216597002648	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
216597002649	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
216597002650	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
216597002651	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
216597002652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597002653	dimer interface [polypeptide binding]; other site
216597002654	conserved gate region; other site
216597002655	putative PBP binding loops; other site
216597002656	ABC-ATPase subunit interface; other site
216597002657	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
216597002658	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
216597002659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597002660	dimer interface [polypeptide binding]; other site
216597002661	conserved gate region; other site
216597002662	putative PBP binding loops; other site
216597002663	ABC-ATPase subunit interface; other site
216597002664	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
216597002665	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
216597002666	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597002667	FeS/SAM binding site; other site
216597002668	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
216597002669	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
216597002670	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
216597002671	Ligand binding site [chemical binding]; other site
216597002672	Electron transfer flavoprotein domain; Region: ETF; pfam01012
216597002673	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
216597002674	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
216597002675	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
216597002676	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
216597002677	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216597002678	active site
216597002679	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
216597002680	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216597002681	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
216597002682	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
216597002683	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597002684	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597002685	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
216597002686	putative dimerization interface [polypeptide binding]; other site
216597002687	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
216597002688	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
216597002689	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
216597002690	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
216597002691	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
216597002692	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
216597002693	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216597002694	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
216597002695	putative C-terminal domain interface [polypeptide binding]; other site
216597002696	putative GSH binding site (G-site) [chemical binding]; other site
216597002697	putative dimer interface [polypeptide binding]; other site
216597002698	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
216597002699	putative N-terminal domain interface [polypeptide binding]; other site
216597002700	putative dimer interface [polypeptide binding]; other site
216597002701	putative substrate binding pocket (H-site) [chemical binding]; other site
216597002702	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
216597002703	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
216597002704	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
216597002705	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
216597002706	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
216597002707	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216597002708	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
216597002709	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
216597002710	active site
216597002711	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
216597002712	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597002713	putative substrate translocation pore; other site
216597002714	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
216597002715	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597002716	active site
216597002717	motif I; other site
216597002718	motif II; other site
216597002719	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597002720	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597002721	putative substrate translocation pore; other site
216597002722	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216597002723	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
216597002724	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597002725	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
216597002726	putative transporter; Provisional; Region: PRK04972
216597002727	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
216597002728	TrkA-C domain; Region: TrkA_C; pfam02080
216597002729	TrkA-C domain; Region: TrkA_C; pfam02080
216597002730	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
216597002731	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
216597002732	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
216597002733	GSH binding site [chemical binding]; other site
216597002734	catalytic residues [active]
216597002735	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
216597002737	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
216597002738	RimK-like ATP-grasp domain; Region: RimK; pfam08443
216597002739	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
216597002740	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
216597002741	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
216597002742	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
216597002743	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597002744	Walker A/P-loop; other site
216597002745	ATP binding site [chemical binding]; other site
216597002746	Q-loop/lid; other site
216597002747	ABC transporter signature motif; other site
216597002748	Walker B; other site
216597002749	D-loop; other site
216597002750	H-loop/switch region; other site
216597002751	TOBE domain; Region: TOBE_2; pfam08402
216597002752	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
216597002753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597002754	dimer interface [polypeptide binding]; other site
216597002755	conserved gate region; other site
216597002756	putative PBP binding loops; other site
216597002757	ABC-ATPase subunit interface; other site
216597002758	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
216597002759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597002760	dimer interface [polypeptide binding]; other site
216597002761	conserved gate region; other site
216597002762	putative PBP binding loops; other site
216597002763	ABC-ATPase subunit interface; other site
216597002764	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
216597002765	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
216597002766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597002767	S-adenosylmethionine binding site [chemical binding]; other site
216597002768	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
216597002769	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
216597002770	active site
216597002771	P-loop; other site
216597002772	phosphorylation site [posttranslational modification]
216597002773	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
216597002774	Sulfatase; Region: Sulfatase; cl17466
216597002775	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
216597002776	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597002777	substrate binding pocket [chemical binding]; other site
216597002778	membrane-bound complex binding site; other site
216597002779	hinge residues; other site
216597002780	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597002781	dimer interface [polypeptide binding]; other site
216597002782	conserved gate region; other site
216597002783	putative PBP binding loops; other site
216597002784	ABC-ATPase subunit interface; other site
216597002785	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216597002786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597002787	dimer interface [polypeptide binding]; other site
216597002788	conserved gate region; other site
216597002789	putative PBP binding loops; other site
216597002790	ABC-ATPase subunit interface; other site
216597002791	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
216597002792	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597002793	substrate binding pocket [chemical binding]; other site
216597002794	membrane-bound complex binding site; other site
216597002795	hinge residues; other site
216597002796	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
216597002797	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597002798	Walker A/P-loop; other site
216597002799	ATP binding site [chemical binding]; other site
216597002800	Q-loop/lid; other site
216597002801	ABC transporter signature motif; other site
216597002802	Walker B; other site
216597002803	D-loop; other site
216597002804	H-loop/switch region; other site
216597002805	putative lipoprotein; Provisional; Region: PRK10533
216597002806	hypothetical protein; Provisional; Region: PRK02877
216597002807	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
216597002808	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
216597002809	amidase catalytic site [active]
216597002810	Zn binding residues [ion binding]; other site
216597002811	substrate binding site [chemical binding]; other site
216597002812	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216597002813	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216597002814	NAD(P) binding site [chemical binding]; other site
216597002815	active site
216597002816	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
216597002817	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
216597002818	putative NAD(P) binding site [chemical binding]; other site
216597002819	putative active site [active]
216597002820	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
216597002821	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
216597002822	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
216597002823	tetramer interface [polypeptide binding]; other site
216597002824	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597002825	catalytic residue [active]
216597002826	pyruvate dehydrogenase; Provisional; Region: PRK09124
216597002827	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
216597002828	PYR/PP interface [polypeptide binding]; other site
216597002829	dimer interface [polypeptide binding]; other site
216597002830	tetramer interface [polypeptide binding]; other site
216597002831	TPP binding site [chemical binding]; other site
216597002832	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216597002833	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
216597002834	TPP-binding site [chemical binding]; other site
216597002835	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
216597002836	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
216597002837	FAD binding pocket [chemical binding]; other site
216597002838	FAD binding motif [chemical binding]; other site
216597002839	phosphate binding motif [ion binding]; other site
216597002840	beta-alpha-beta structure motif; other site
216597002841	NAD binding pocket [chemical binding]; other site
216597002842	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216597002843	catalytic loop [active]
216597002844	iron binding site [ion binding]; other site
216597002845	hybrid cluster protein; Provisional; Region: PRK05290
216597002846	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
216597002847	ACS interaction site; other site
216597002848	CODH interaction site; other site
216597002849	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
216597002850	hybrid metal cluster; other site
216597002851	Predicted membrane protein [Function unknown]; Region: COG2431
216597002852	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
216597002853	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
216597002854	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
216597002855	putative active site [active]
216597002856	putative metal-binding site [ion binding]; other site
216597002857	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
216597002858	macrolide transporter subunit MacA; Provisional; Region: PRK11578
216597002859	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216597002860	HlyD family secretion protein; Region: HlyD_3; pfam13437
216597002861	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
216597002862	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
216597002863	Walker A/P-loop; other site
216597002864	ATP binding site [chemical binding]; other site
216597002865	Q-loop/lid; other site
216597002866	ABC transporter signature motif; other site
216597002867	Walker B; other site
216597002868	D-loop; other site
216597002869	H-loop/switch region; other site
216597002870	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
216597002871	FtsX-like permease family; Region: FtsX; pfam02687
216597002872	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
216597002873	DNA-binding site [nucleotide binding]; DNA binding site
216597002874	RNA-binding motif; other site
216597002875	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
216597002876	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
216597002877	Clp amino terminal domain; Region: Clp_N; pfam02861
216597002878	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597002879	Walker A motif; other site
216597002880	ATP binding site [chemical binding]; other site
216597002881	Walker B motif; other site
216597002882	arginine finger; other site
216597002883	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597002884	Walker A motif; other site
216597002885	ATP binding site [chemical binding]; other site
216597002886	Walker B motif; other site
216597002887	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
216597002888	Transposase IS200 like; Region: Y1_Tnp; pfam01797
216597002889	Integrase core domain; Region: rve; pfam00665
216597002890	Integrase core domain; Region: rve_3; pfam13683
216597002891	Helix-turn-helix domain; Region: HTH_28; pfam13518
216597002892	Isochorismatase family; Region: Isochorismatase; pfam00857
216597002893	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
216597002894	catalytic triad [active]
216597002895	dimer interface [polypeptide binding]; other site
216597002896	conserved cis-peptide bond; other site
216597002897	Pirin-related protein [General function prediction only]; Region: COG1741
216597002898	Pirin; Region: Pirin; pfam02678
216597002899	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
216597002900	LysR family transcriptional regulator; Provisional; Region: PRK14997
216597002901	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597002902	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
216597002903	putative effector binding pocket; other site
216597002904	putative dimerization interface [polypeptide binding]; other site
216597002905	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
216597002906	rRNA binding site [nucleotide binding]; other site
216597002907	predicted 30S ribosome binding site; other site
216597002908	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
216597002909	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
216597002910	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216597002911	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597002912	Walker A/P-loop; other site
216597002913	ATP binding site [chemical binding]; other site
216597002914	Q-loop/lid; other site
216597002915	ABC transporter signature motif; other site
216597002916	Walker B; other site
216597002917	D-loop; other site
216597002918	H-loop/switch region; other site
216597002919	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
216597002920	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216597002921	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597002922	Walker A/P-loop; other site
216597002923	ATP binding site [chemical binding]; other site
216597002924	Q-loop/lid; other site
216597002925	ABC transporter signature motif; other site
216597002926	Walker B; other site
216597002927	D-loop; other site
216597002928	H-loop/switch region; other site
216597002929	thioredoxin reductase; Provisional; Region: PRK10262
216597002930	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216597002931	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216597002932	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
216597002933	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216597002934	putative DNA binding site [nucleotide binding]; other site
216597002935	putative Zn2+ binding site [ion binding]; other site
216597002936	AsnC family; Region: AsnC_trans_reg; pfam01037
216597002937	DNA translocase FtsK; Provisional; Region: PRK10263
216597002938	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
216597002939	DNA translocase FtsK; Provisional; Region: PRK10263
216597002940	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
216597002941	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
216597002942	periplasmic chaperone LolA; Region: lolA; TIGR00547
216597002943	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
216597002944	recombination factor protein RarA; Reviewed; Region: PRK13342
216597002945	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597002946	Walker A motif; other site
216597002947	ATP binding site [chemical binding]; other site
216597002948	Walker B motif; other site
216597002949	arginine finger; other site
216597002950	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
216597002951	seryl-tRNA synthetase; Provisional; Region: PRK05431
216597002952	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
216597002953	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
216597002954	dimer interface [polypeptide binding]; other site
216597002955	active site
216597002956	motif 1; other site
216597002957	motif 2; other site
216597002958	motif 3; other site
216597002959	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
216597002960	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
216597002961	putative [Fe4-S4] binding site [ion binding]; other site
216597002962	putative molybdopterin cofactor binding site [chemical binding]; other site
216597002963	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
216597002964	putative molybdopterin cofactor binding site; other site
216597002965	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
216597002966	4Fe-4S binding domain; Region: Fer4; pfam00037
216597002967	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
216597002968	putative MFS family transporter protein; Provisional; Region: PRK03633
216597002969	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597002970	putative substrate translocation pore; other site
216597002971	inner membrane transporter YjeM; Provisional; Region: PRK15238
216597002972	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
216597002973	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597002974	FeS/SAM binding site; other site
216597002975	pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380
216597002976	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
216597002977	Pyruvate formate lyase 1; Region: PFL1; cd01678
216597002978	coenzyme A binding site [chemical binding]; other site
216597002979	active site
216597002980	catalytic residues [active]
216597002981	glycine loop; other site
216597002982	formate transporter; Provisional; Region: PRK10805
216597002983	uncharacterized domain; Region: TIGR00702
216597002984	YcaO-like family; Region: YcaO; pfam02624
216597002985	Predicted membrane protein [Function unknown]; Region: COG2323
216597002986	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
216597002987	homodimer interface [polypeptide binding]; other site
216597002988	substrate-cofactor binding pocket; other site
216597002989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597002990	catalytic residue [active]
216597002991	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
216597002992	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
216597002993	hinge; other site
216597002994	active site
216597002995	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
216597002996	cytidylate kinase; Provisional; Region: cmk; PRK00023
216597002997	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
216597002998	CMP-binding site; other site
216597002999	The sites determining sugar specificity; other site
216597003000	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
216597003001	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
216597003002	RNA binding site [nucleotide binding]; other site
216597003003	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
216597003004	RNA binding site [nucleotide binding]; other site
216597003005	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
216597003006	RNA binding site [nucleotide binding]; other site
216597003007	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
216597003008	RNA binding site [nucleotide binding]; other site
216597003009	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
216597003010	RNA binding site [nucleotide binding]; other site
216597003011	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
216597003012	IHF dimer interface [polypeptide binding]; other site
216597003013	IHF - DNA interface [nucleotide binding]; other site
216597003014	ComEC family competence protein; Provisional; Region: PRK11539
216597003015	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
216597003016	Competence protein; Region: Competence; pfam03772
216597003017	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
216597003018	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
216597003019	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216597003020	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
216597003021	Walker A/P-loop; other site
216597003022	ATP binding site [chemical binding]; other site
216597003023	Q-loop/lid; other site
216597003024	ABC transporter signature motif; other site
216597003025	Walker B; other site
216597003026	D-loop; other site
216597003027	H-loop/switch region; other site
216597003028	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
216597003029	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
216597003030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
216597003031	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
216597003032	hypothetical protein; Provisional; Region: PRK11827
216597003033	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
216597003034	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
216597003035	Ligand binding site; other site
216597003036	oligomer interface; other site
216597003037	hypothetical protein; Provisional; Region: PRK10593
216597003038	Uncharacterized conserved protein [Function unknown]; Region: COG1434
216597003039	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
216597003040	putative active site [active]
216597003041	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
216597003042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597003043	S-adenosylmethionine binding site [chemical binding]; other site
216597003044	condesin subunit F; Provisional; Region: PRK05260
216597003045	condesin subunit E; Provisional; Region: PRK05256
216597003046	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
216597003047	P-loop containing region of AAA domain; Region: AAA_29; cl17516
216597003048	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
216597003049	murein L,D-transpeptidase; Provisional; Region: PRK10594
216597003050	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
216597003051	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
216597003052	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
216597003053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
216597003054	Peptidase M15; Region: Peptidase_M15_3; cl01194
216597003055	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
216597003056	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
216597003057	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216597003058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597003059	homodimer interface [polypeptide binding]; other site
216597003060	catalytic residue [active]
216597003061	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
216597003062	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
216597003063	trimer interface [polypeptide binding]; other site
216597003064	eyelet of channel; other site
216597003065	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
216597003066	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
216597003067	putative dimer interface [polypeptide binding]; other site
216597003068	putative anticodon binding site; other site
216597003069	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
216597003070	homodimer interface [polypeptide binding]; other site
216597003071	motif 1; other site
216597003072	motif 2; other site
216597003073	active site
216597003074	motif 3; other site
216597003075	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216597003076	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216597003077	putative DNA binding site [nucleotide binding]; other site
216597003078	putative Zn2+ binding site [ion binding]; other site
216597003079	AsnC family; Region: AsnC_trans_reg; pfam01037
216597003080	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
216597003081	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
216597003082	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216597003083	catalytic residue [active]
216597003084	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
216597003085	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
216597003086	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
216597003087	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
216597003088	active site
216597003089	only difference between Gifsy-2 (LT2) and this one is an insertion of 160-200 bps in the LT2 Gifsy-2 Tail fibre sequence STM1049
216597003090	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
216597003091	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
216597003092	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
216597003093	Int/Topo IB signature motif; other site
216597003094	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
216597003095	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
216597003096	RecT family; Region: RecT; pfam03837
216597003097	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
216597003098	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
216597003099	Helix-turn-helix; Region: HTH_3; pfam01381
216597003100	Bacteriophage CII protein; Region: Phage_CII; pfam05269
216597003101	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
216597003102	primosomal protein DnaI; Provisional; Region: PRK02854
216597003103	putative replication protein; Provisional; Region: PRK12377
216597003104	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597003105	Walker A motif; other site
216597003106	ATP binding site [chemical binding]; other site
216597003107	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
216597003108	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
216597003109	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
216597003110	DinI-like family; Region: DinI; pfam06183
216597003111	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
216597003112	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
216597003113	Antitermination protein; Region: Antiterm; pfam03589
216597003114	Antitermination protein; Region: Antiterm; pfam03589
216597003115	PipA protein; Region: PipA; pfam07108
216597003116	phage holin, lambda family; Region: holin_lambda; TIGR01594
216597003117	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
216597003118	catalytic residues [active]
216597003119	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
216597003120	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
216597003121	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
216597003122	Domain of unknown function (DUF1859); Region: DUF1859; pfam08948
216597003123	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
216597003124	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
216597003125	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
216597003126	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
216597003127	oligomer interface [polypeptide binding]; other site
216597003128	active site residues [active]
216597003129	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
216597003130	Uncharacterized conserved protein [Function unknown]; Region: COG5471
216597003131	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856
216597003132	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
216597003133	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
216597003134	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
216597003135	phage minor tail protein G; Region: phage_lambda_G; TIGR01674
216597003136	Minor tail protein T; Region: Phage_tail_T; cl05636
216597003137	Phage-related minor tail protein [Function unknown]; Region: COG5281
216597003138	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
216597003139	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
216597003140	Phage-related protein [Function unknown]; Region: COG4718
216597003141	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
216597003142	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
216597003143	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
216597003144	E-class dimer interface [polypeptide binding]; other site
216597003145	P-class dimer interface [polypeptide binding]; other site
216597003146	active site
216597003147	Cu2+ binding site [ion binding]; other site
216597003148	Zn2+ binding site [ion binding]; other site
216597003149	Phage-related protein [Function unknown]; Region: gp18; COG4672
216597003150	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
216597003151	MPN+ (JAMM) motif; other site
216597003152	Zinc-binding site [ion binding]; other site
216597003153	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
216597003154	NlpC/P60 family; Region: NLPC_P60; cl17555
216597003155	Phage-related protein, tail component [Function unknown]; Region: COG4723
216597003156	Phage-related protein, tail component [Function unknown]; Region: COG4733
216597003157	Putative phage tail protein; Region: Phage-tail_3; pfam13550
216597003158	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
216597003159	Interdomain contacts; other site
216597003160	Cytokine receptor motif; other site
216597003161	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
216597003162	Fibronectin type III protein; Region: DUF3672; pfam12421
216597003163	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
216597003164	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
216597003165	Phage Tail Collar Domain; Region: Collar; pfam07484
216597003166	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
216597003168	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
216597003170	hypothetical protein; Provisional; Region: PRK09951
216597003171	DinI-like family; Region: DinI; cl11630
216597003172	aminopeptidase N; Provisional; Region: pepN; PRK14015
216597003173	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
216597003174	active site
216597003175	Zn binding site [ion binding]; other site
216597003176	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
216597003177	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
216597003178	quinone interaction residues [chemical binding]; other site
216597003179	active site
216597003180	catalytic residues [active]
216597003181	FMN binding site [chemical binding]; other site
216597003182	substrate binding site [chemical binding]; other site
216597003183	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
216597003184	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
216597003185	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
216597003186	MOSC domain; Region: MOSC; pfam03473
216597003187	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
216597003188	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216597003189	catalytic loop [active]
216597003190	iron binding site [ion binding]; other site
216597003191	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
216597003192	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
216597003193	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
216597003194	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597003195	S-adenosylmethionine binding site [chemical binding]; other site
216597003196	ABC transporter ATPase component; Reviewed; Region: PRK11147
216597003197	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597003198	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597003199	Walker A/P-loop; other site
216597003200	Walker A/P-loop; other site
216597003201	ATP binding site [chemical binding]; other site
216597003202	ATP binding site [chemical binding]; other site
216597003203	Q-loop/lid; other site
216597003204	Q-loop/lid; other site
216597003205	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216597003206	ABC transporter signature motif; other site
216597003207	Walker B; other site
216597003208	D-loop; other site
216597003209	ABC transporter; Region: ABC_tran_2; pfam12848
216597003210	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216597003211	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
216597003212	Paraquat-inducible protein A; Region: PqiA; pfam04403
216597003213	Paraquat-inducible protein A; Region: PqiA; pfam04403
216597003214	paraquat-inducible protein B; Provisional; Region: PRK10807
216597003215	mce related protein; Region: MCE; pfam02470
216597003216	mce related protein; Region: MCE; pfam02470
216597003217	mce related protein; Region: MCE; pfam02470
216597003218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
216597003219	Protein of unknown function (DUF330); Region: DUF330; pfam03886
216597003220	ribosome modulation factor; Provisional; Region: PRK14563
216597003221	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
216597003222	active site 1 [active]
216597003223	dimer interface [polypeptide binding]; other site
216597003224	active site 2 [active]
216597003225	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
216597003226	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
216597003227	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
216597003228	outer membrane protein A; Reviewed; Region: PRK10808
216597003229	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
216597003230	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216597003231	ligand binding site [chemical binding]; other site
216597003232	cell division inhibitor SulA; Region: sula; TIGR00623
216597003233	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
216597003234	TfoX C-terminal domain; Region: TfoX_C; pfam04994
216597003235	TIGR01666 family membrane protein; Region: YCCS
216597003236	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
216597003237	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
216597003238	Predicted membrane protein [Function unknown]; Region: COG3304
216597003239	Domain of unknown function (DUF307); Region: DUF307; pfam03733
216597003240	Domain of unknown function (DUF307); Region: DUF307; pfam03733
216597003241	DNA helicase IV; Provisional; Region: helD; PRK11054
216597003242	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
216597003243	Part of AAA domain; Region: AAA_19; pfam13245
216597003244	Family description; Region: UvrD_C_2; pfam13538
216597003245	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
216597003246	active site
216597003247	dimer interfaces [polypeptide binding]; other site
216597003248	catalytic residues [active]
216597003249	hypothetical protein; Provisional; Region: PRK03641
216597003250	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110
216597003251	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
216597003252	heat shock protein HspQ; Provisional; Region: PRK14129
216597003253	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
216597003254	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
216597003255	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
216597003256	putative RNA binding site [nucleotide binding]; other site
216597003257	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597003258	S-adenosylmethionine binding site [chemical binding]; other site
216597003259	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
216597003260	substrate binding site [chemical binding]; other site
216597003261	Cupin domain; Region: Cupin_2; cl17218
216597003262	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216597003263	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597003264	acylphosphatase; Provisional; Region: PRK14426
216597003265	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
216597003266	sulfur transfer protein TusE; Provisional; Region: PRK11508
216597003267	YccA-like proteins; Region: YccA_like; cd10433
216597003268	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
216597003269	PipA protein; Region: PipA; pfam07108
216597003270	secreted effector protein PipB; Provisional; Region: PRK15197
216597003271	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
216597003272	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
216597003273	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
216597003274	type III secretion chaperone protein SigE; Provisional; Region: PRK15202
216597003275	inositol phosphate phosphatase SopB; Provisional; Region: PRK15378
216597003276	Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925
216597003277	Domain of unknown function (DUF3950); Region: DUF3950; pfam13132
216597003278	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
216597003279	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
216597003280	HAMP domain; Region: HAMP; pfam00672
216597003281	dimerization interface [polypeptide binding]; other site
216597003282	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597003283	dimer interface [polypeptide binding]; other site
216597003284	phosphorylation site [posttranslational modification]
216597003285	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597003286	ATP binding site [chemical binding]; other site
216597003287	Mg2+ binding site [ion binding]; other site
216597003288	G-X-G motif; other site
216597003289	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
216597003290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597003291	active site
216597003292	phosphorylation site [posttranslational modification]
216597003293	intermolecular recognition site; other site
216597003294	dimerization interface [polypeptide binding]; other site
216597003295	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597003296	DNA binding site [nucleotide binding]
216597003297	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
216597003298	active site
216597003299	homotetramer interface [polypeptide binding]; other site
216597003300	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
216597003301	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
216597003302	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
216597003303	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
216597003304	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216597003305	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203
216597003306	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
216597003307	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
216597003308	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
216597003309	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
216597003310	NAD binding site [chemical binding]; other site
216597003311	catalytic residues [active]
216597003312	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
216597003313	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
216597003314	putative active site [active]
216597003315	putative metal binding site [ion binding]; other site
216597003316	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
216597003317	putative substrate binding pocket [chemical binding]; other site
216597003318	trimer interface [polypeptide binding]; other site
216597003319	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
216597003320	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
216597003321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597003322	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
216597003323	putative substrate translocation pore; other site
216597003324	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
216597003325	Cupin domain; Region: Cupin_2; pfam07883
216597003326	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597003327	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
216597003328	anti-adapter protein IraM; Provisional; Region: PRK09919
216597003329	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
216597003330	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
216597003331	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
216597003332	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
216597003333	HSP70 interaction site [polypeptide binding]; other site
216597003334	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
216597003335	substrate binding site [polypeptide binding]; other site
216597003336	dimer interface [polypeptide binding]; other site
216597003337	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
216597003338	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
216597003339	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
216597003340	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
216597003341	DsbD alpha interface [polypeptide binding]; other site
216597003342	catalytic residues [active]
216597003343	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
216597003344	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
216597003345	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
216597003346	catalytic residues [active]
216597003347	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
216597003348	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
216597003349	catalytic residues [active]
216597003350	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
216597003351	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
216597003352	catalytic core [active]
216597003353	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
216597003354	hypothetical protein; Provisional; Region: PRK10174
216597003355	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
216597003356	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
216597003357	General stress protein [General function prediction only]; Region: GsiB; COG3729
216597003358	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
216597003359	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597003360	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
216597003361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
216597003362	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
216597003363	Predicted transcriptional regulator [Transcription]; Region: COG3905
216597003364	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
216597003365	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
216597003366	Glutamate binding site [chemical binding]; other site
216597003367	NAD binding site [chemical binding]; other site
216597003368	catalytic residues [active]
216597003369	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
216597003370	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
216597003371	Na binding site [ion binding]; other site
216597003372	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
216597003373	hypothetical protein; Provisional; Region: PRK10536
216597003374	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
216597003375	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
216597003376	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
216597003377	putative active site [active]
216597003378	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
216597003379	Na binding site [ion binding]; other site
216597003380	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
216597003381	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
216597003382	putative active site cavity [active]
216597003383	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
216597003384	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
216597003385	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
216597003386	putative sialic acid transporter; Provisional; Region: PRK12307
216597003387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597003388	putative substrate translocation pore; other site
216597003389	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
216597003390	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216597003391	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
216597003392	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
216597003393	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
216597003394	putative ligand binding site [chemical binding]; other site
216597003395	NAD binding site [chemical binding]; other site
216597003396	dimerization interface [polypeptide binding]; other site
216597003397	catalytic site [active]
216597003398	putative hydrolase; Validated; Region: PRK09248
216597003399	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
216597003400	active site
216597003401	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
216597003402	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
216597003403	curli production assembly/transport protein CsgG; Provisional; Region: PRK15184
216597003404	curli assembly protein CsgF; Provisional; Region: PRK10050
216597003405	curli assembly protein CsgE; Provisional; Region: PRK10386
216597003406	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
216597003407	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597003408	DNA binding residues [nucleotide binding]
216597003409	dimerization interface [polypeptide binding]; other site
216597003410	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
216597003411	Curlin associated repeat; Region: Curlin_rpt; pfam07012
216597003412	Curlin associated repeat; Region: Curlin_rpt; pfam07012
216597003413	major curlin subunit; Provisional; Region: csgA; PRK10051
216597003414	Curlin associated repeat; Region: Curlin_rpt; pfam07012
216597003415	curli assembly protein CsgC; Provisional; Region: csgC; PRK10102
216597003416	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
216597003417	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
216597003418	putative ADP-ribose binding site [chemical binding]; other site
216597003419	putative active site [active]
216597003420	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
216597003421	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
216597003422	putative active site [active]
216597003423	catalytic site [active]
216597003424	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
216597003425	putative active site [active]
216597003426	catalytic site [active]
216597003427	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
216597003428	Acyltransferase family; Region: Acyl_transf_3; pfam01757
216597003429	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
216597003430	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349
216597003431	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
216597003432	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
216597003433	Ligand binding site; other site
216597003434	DXD motif; other site
216597003435	lipoprotein; Provisional; Region: PRK10175
216597003436	secY/secA suppressor protein; Provisional; Region: PRK11467
216597003437	drug efflux system protein MdtG; Provisional; Region: PRK09874
216597003438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597003439	putative substrate translocation pore; other site
216597003440	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
216597003441	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
216597003442	putative acyl-acceptor binding pocket; other site
216597003443	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
216597003444	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
216597003445	active site residue [active]
216597003446	hypothetical protein; Provisional; Region: PRK03757
216597003447	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
216597003448	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
216597003449	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
216597003450	hydroxyglutarate oxidase; Provisional; Region: PRK11728
216597003451	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
216597003452	DNA damage-inducible protein I; Provisional; Region: PRK10597
216597003453	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
216597003454	active site
216597003455	substrate binding pocket [chemical binding]; other site
216597003456	dimer interface [polypeptide binding]; other site
216597003457	lipoprotein; Provisional; Region: PRK10598
216597003458	glutaredoxin 2; Provisional; Region: PRK10387
216597003459	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
216597003460	C-terminal domain interface [polypeptide binding]; other site
216597003461	GSH binding site (G-site) [chemical binding]; other site
216597003462	catalytic residues [active]
216597003463	putative dimer interface [polypeptide binding]; other site
216597003464	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
216597003465	N-terminal domain interface [polypeptide binding]; other site
216597003466	multidrug resistance protein MdtH; Provisional; Region: PRK11646
216597003467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597003468	putative substrate translocation pore; other site
216597003469	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
216597003470	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
216597003471	hypothetical protein; Provisional; Region: PRK11239
216597003472	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
216597003473	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
216597003474	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216597003475	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
216597003476	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
216597003477	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
216597003478	flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459
216597003479	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
216597003480	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
216597003481	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
216597003482	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
216597003483	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
216597003484	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
216597003485	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
216597003486	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
216597003487	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
216597003488	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
216597003489	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
216597003490	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
216597003491	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
216597003492	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
216597003493	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
216597003494	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
216597003495	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
216597003496	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
216597003497	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
216597003498	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
216597003499	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
216597003500	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
216597003501	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
216597003502	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
216597003503	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
216597003504	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
216597003505	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
216597003506	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
216597003507	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
216597003508	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
216597003509	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
216597003510	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
216597003511	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
216597003512	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
216597003513	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
216597003514	homodimer interface [polypeptide binding]; other site
216597003515	oligonucleotide binding site [chemical binding]; other site
216597003516	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
216597003517	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
216597003518	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216597003519	RNA binding surface [nucleotide binding]; other site
216597003520	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
216597003521	active site
216597003522	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
216597003523	Maf-like protein; Region: Maf; pfam02545
216597003524	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
216597003525	active site
216597003526	dimer interface [polypeptide binding]; other site
216597003527	hypothetical protein; Provisional; Region: PRK11193
216597003528	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
216597003529	putative phosphate acyltransferase; Provisional; Region: PRK05331
216597003530	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
216597003531	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
216597003532	dimer interface [polypeptide binding]; other site
216597003533	active site
216597003534	CoA binding pocket [chemical binding]; other site
216597003535	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
216597003536	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
216597003537	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
216597003538	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
216597003539	NAD(P) binding site [chemical binding]; other site
216597003540	homotetramer interface [polypeptide binding]; other site
216597003541	homodimer interface [polypeptide binding]; other site
216597003542	active site
216597003543	acyl carrier protein; Provisional; Region: acpP; PRK00982
216597003544	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
216597003545	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
216597003546	dimer interface [polypeptide binding]; other site
216597003547	active site
216597003548	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
216597003549	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
216597003550	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597003551	catalytic residue [active]
216597003552	conserved hypothetical protein, YceG family; Region: TIGR00247
216597003553	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
216597003554	dimerization interface [polypeptide binding]; other site
216597003555	thymidylate kinase; Validated; Region: tmk; PRK00698
216597003556	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
216597003557	TMP-binding site; other site
216597003558	ATP-binding site [chemical binding]; other site
216597003559	DNA polymerase III subunit delta'; Validated; Region: PRK07993
216597003560	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
216597003561	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
216597003562	active site
216597003563	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
216597003564	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
216597003565	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
216597003566	active site turn [active]
216597003567	phosphorylation site [posttranslational modification]
216597003568	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
216597003569	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216597003570	N-terminal plug; other site
216597003571	ligand-binding site [chemical binding]; other site
216597003572	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
216597003573	nucleotide binding site/active site [active]
216597003574	HIT family signature motif; other site
216597003575	catalytic residue [active]
216597003576	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
216597003577	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
216597003578	putative dimer interface [polypeptide binding]; other site
216597003579	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
216597003580	thiamine kinase; Region: ycfN_thiK; TIGR02721
216597003581	thiamine kinase; Provisional; Region: thiK; PRK10271
216597003582	substrate binding site [chemical binding]; other site
216597003583	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
216597003584	beta-hexosaminidase; Provisional; Region: PRK05337
216597003585	hypothetical protein; Provisional; Region: PRK04940
216597003586	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
216597003587	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216597003588	hypothetical protein; Provisional; Region: PRK11280
216597003589	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216597003590	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597003591	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
216597003592	L,D-transpeptidase; Provisional; Region: PRK10190
216597003593	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216597003594	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
216597003595	transcription-repair coupling factor; Provisional; Region: PRK10689
216597003596	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
216597003597	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216597003598	ATP binding site [chemical binding]; other site
216597003599	putative Mg++ binding site [ion binding]; other site
216597003600	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597003601	nucleotide binding region [chemical binding]; other site
216597003602	ATP-binding site [chemical binding]; other site
216597003603	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
216597003604	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
216597003605	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
216597003606	FtsX-like permease family; Region: FtsX; pfam02687
216597003607	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
216597003608	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
216597003609	Walker A/P-loop; other site
216597003610	ATP binding site [chemical binding]; other site
216597003611	Q-loop/lid; other site
216597003612	ABC transporter signature motif; other site
216597003613	Walker B; other site
216597003614	D-loop; other site
216597003615	H-loop/switch region; other site
216597003616	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
216597003617	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
216597003618	FtsX-like permease family; Region: FtsX; pfam02687
216597003619	fructokinase; Reviewed; Region: PRK09557
216597003620	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
216597003621	nucleotide binding site [chemical binding]; other site
216597003622	NAD-dependent deacetylase; Provisional; Region: PRK00481
216597003623	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
216597003624	NAD+ binding site [chemical binding]; other site
216597003625	substrate binding site [chemical binding]; other site
216597003626	Zn binding site [ion binding]; other site
216597003627	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
216597003628	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
216597003629	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
216597003630	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597003631	dimer interface [polypeptide binding]; other site
216597003632	conserved gate region; other site
216597003633	putative PBP binding loops; other site
216597003634	ABC-ATPase subunit interface; other site
216597003635	Sif protein; Region: Sif; pfam06767
216597003636	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
216597003637	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597003638	dimer interface [polypeptide binding]; other site
216597003639	conserved gate region; other site
216597003640	putative PBP binding loops; other site
216597003641	ABC-ATPase subunit interface; other site
216597003642	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
216597003643	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597003644	Walker A/P-loop; other site
216597003645	ATP binding site [chemical binding]; other site
216597003646	Q-loop/lid; other site
216597003647	ABC transporter signature motif; other site
216597003648	Walker B; other site
216597003649	D-loop; other site
216597003650	H-loop/switch region; other site
216597003651	TOBE domain; Region: TOBE_2; pfam08402
216597003652	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
216597003653	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
216597003654	metal binding site [ion binding]; metal-binding site
216597003655	dimer interface [polypeptide binding]; other site
216597003657	Transposase IS200 like; Region: Y1_Tnp; pfam01797
216597003658	Uncharacterized conserved protein [Function unknown]; Region: COG2850
216597003659	Cupin-like domain; Region: Cupin_8; pfam13621
216597003660	sensor protein PhoQ; Provisional; Region: PRK10815
216597003661	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
216597003662	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
216597003663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597003664	ATP binding site [chemical binding]; other site
216597003665	Mg2+ binding site [ion binding]; other site
216597003666	G-X-G motif; other site
216597003667	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
216597003668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597003669	active site
216597003670	phosphorylation site [posttranslational modification]
216597003671	intermolecular recognition site; other site
216597003672	dimerization interface [polypeptide binding]; other site
216597003673	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597003674	DNA binding site [nucleotide binding]
216597003675	adenylosuccinate lyase; Provisional; Region: PRK09285
216597003676	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
216597003677	tetramer interface [polypeptide binding]; other site
216597003678	active site
216597003679	putative lysogenization regulator; Reviewed; Region: PRK00218
216597003680	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
216597003681	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
216597003682	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
216597003683	nudix motif; other site
216597003684	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
216597003685	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
216597003686	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
216597003687	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
216597003688	probable active site [active]
216597003689	isocitrate dehydrogenase; Validated; Region: PRK07362
216597003690	isocitrate dehydrogenase; Reviewed; Region: PRK07006
216597003691	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
216597003692	DinI-like family; Region: DinI; pfam06183
216597003693	Ricin-type beta-trefoil; Region: RICIN; smart00458
216597003694	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
216597003695	putative sugar binding sites [chemical binding]; other site
216597003696	Q-X-W motif; other site
216597003697	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
216597003698	DNA-binding site [nucleotide binding]; DNA binding site
216597003699	RNA-binding motif; other site
216597003700	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
216597003701	lysozyme inhibitor; Provisional; Region: PRK13791
216597003702	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
216597003703	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
216597003704	putative dimer interface [polypeptide binding]; other site
216597003705	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
216597003706	BNR repeat-like domain; Region: BNR_2; pfam13088
216597003707	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
216597003708	TRL-like protein family; Region: TRL; pfam13146
216597003709	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
216597003710	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
216597003711	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
216597003712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597003713	dimer interface [polypeptide binding]; other site
216597003714	conserved gate region; other site
216597003715	ABC-ATPase subunit interface; other site
216597003716	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
216597003717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597003718	dimer interface [polypeptide binding]; other site
216597003719	conserved gate region; other site
216597003720	putative PBP binding loops; other site
216597003721	ABC-ATPase subunit interface; other site
216597003722	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216597003723	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
216597003724	Walker A/P-loop; other site
216597003725	ATP binding site [chemical binding]; other site
216597003726	Q-loop/lid; other site
216597003727	ABC transporter signature motif; other site
216597003728	Walker B; other site
216597003729	D-loop; other site
216597003730	H-loop/switch region; other site
216597003731	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597003732	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
216597003733	Walker A/P-loop; other site
216597003734	ATP binding site [chemical binding]; other site
216597003735	Q-loop/lid; other site
216597003736	ABC transporter signature motif; other site
216597003737	Walker B; other site
216597003738	D-loop; other site
216597003739	H-loop/switch region; other site
216597003740	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
216597003741	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216597003742	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
216597003743	dimerization interface [polypeptide binding]; other site
216597003744	zinc/cadmium-binding protein; Provisional; Region: PRK10306
216597003745	aminoglycoside resistance protein; Provisional; Region: PRK13746
216597003746	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
216597003747	active site
216597003748	NTP binding site [chemical binding]; other site
216597003749	metal binding triad [ion binding]; metal-binding site
216597003750	antibiotic binding site [chemical binding]; other site
216597003751	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
216597003752	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597003753	DNA binding residues [nucleotide binding]
216597003754	transcriptional regulator MirA; Provisional; Region: PRK15043
216597003755	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
216597003756	DNA binding residues [nucleotide binding]
216597003757	dimer interface [polypeptide binding]; other site
216597003758	Pleckstrin homology-like domain; Region: PH-like; cl17171
216597003759	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
216597003760	chorismate mutase; Provisional; Region: PRK08055
216597003761	leucine export protein LeuE; Provisional; Region: PRK10958
216597003763	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
216597003764	hypothetical protein; Provisional; Region: PRK10457
216597003765	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
216597003766	murein hydrolase B; Provisional; Region: PRK10760; cl17906
216597003767	Domain of unknown function (DUF333); Region: DUF333; pfam03891
216597003768	Uncharacterized conserved protein [Function unknown]; Region: COG3189
216597003769	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
216597003770	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597003771	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216597003772	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597003773	Predicted membrane protein [Function unknown]; Region: COG2707
216597003774	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
216597003775	putative deacylase active site [active]
216597003776	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216597003777	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216597003778	metal binding site [ion binding]; metal-binding site
216597003779	active site
216597003780	I-site; other site
216597003781	hypothetical protein; Provisional; Region: PRK05325
216597003782	PrkA family serine protein kinase; Provisional; Region: PRK15455
216597003783	AAA ATPase domain; Region: AAA_16; pfam13191
216597003784	Walker A motif; other site
216597003785	ATP binding site [chemical binding]; other site
216597003786	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
216597003787	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
216597003788	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
216597003789	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597003790	FeS/SAM binding site; other site
216597003791	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
216597003792	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216597003793	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216597003794	active site
216597003795	catalytic tetrad [active]
216597003796	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
216597003797	active site
216597003798	phosphate binding residues; other site
216597003799	catalytic residues [active]
216597003800	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
216597003801	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
216597003802	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
216597003803	methionine sulfoxide reductase B; Provisional; Region: PRK00222
216597003804	SelR domain; Region: SelR; pfam01641
216597003805	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
216597003806	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
216597003807	Isochorismatase family; Region: Isochorismatase; pfam00857
216597003808	catalytic triad [active]
216597003809	metal binding site [ion binding]; metal-binding site
216597003810	conserved cis-peptide bond; other site
216597003811	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
216597003812	active site
216597003813	homodimer interface [polypeptide binding]; other site
216597003814	protease 4; Provisional; Region: PRK10949
216597003815	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
216597003816	tandem repeat interface [polypeptide binding]; other site
216597003817	oligomer interface [polypeptide binding]; other site
216597003818	active site residues [active]
216597003819	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
216597003820	tandem repeat interface [polypeptide binding]; other site
216597003821	oligomer interface [polypeptide binding]; other site
216597003822	active site residues [active]
216597003823	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
216597003824	putative FMN binding site [chemical binding]; other site
216597003825	selenophosphate synthetase; Provisional; Region: PRK00943
216597003826	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
216597003827	dimerization interface [polypeptide binding]; other site
216597003828	putative ATP binding site [chemical binding]; other site
216597003829	DNA topoisomerase III; Provisional; Region: PRK07726
216597003830	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
216597003831	active site
216597003832	putative interdomain interaction site [polypeptide binding]; other site
216597003833	putative metal-binding site [ion binding]; other site
216597003834	putative nucleotide binding site [chemical binding]; other site
216597003835	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
216597003836	domain I; other site
216597003837	DNA binding groove [nucleotide binding]
216597003838	phosphate binding site [ion binding]; other site
216597003839	domain II; other site
216597003840	domain III; other site
216597003841	nucleotide binding site [chemical binding]; other site
216597003842	catalytic site [active]
216597003843	domain IV; other site
216597003844	glutamate dehydrogenase; Provisional; Region: PRK09414
216597003845	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
216597003846	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
216597003847	NAD(P) binding site [chemical binding]; other site
216597003848	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
216597003849	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
216597003850	active site
216597003851	8-oxo-dGMP binding site [chemical binding]; other site
216597003852	nudix motif; other site
216597003853	metal binding site [ion binding]; metal-binding site
216597003854	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
216597003855	putative catalytic site [active]
216597003856	putative phosphate binding site [ion binding]; other site
216597003857	active site
216597003858	metal binding site A [ion binding]; metal-binding site
216597003859	DNA binding site [nucleotide binding]
216597003860	putative AP binding site [nucleotide binding]; other site
216597003861	putative metal binding site B [ion binding]; other site
216597003862	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
216597003863	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216597003864	inhibitor-cofactor binding pocket; inhibition site
216597003865	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597003866	catalytic residue [active]
216597003867	arginine succinyltransferase; Provisional; Region: PRK10456
216597003868	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
216597003869	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
216597003870	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
216597003871	NAD(P) binding site [chemical binding]; other site
216597003872	catalytic residues [active]
216597003873	succinylarginine dihydrolase; Provisional; Region: PRK13281
216597003874	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
216597003875	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
216597003876	putative active site [active]
216597003877	Zn binding site [ion binding]; other site
216597003878	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
216597003879	dimer interface [polypeptide binding]; other site
216597003880	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
216597003881	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
216597003882	GIY-YIG motif/motif A; other site
216597003883	active site
216597003884	catalytic site [active]
216597003885	putative DNA binding site [nucleotide binding]; other site
216597003886	metal binding site [ion binding]; metal-binding site
216597003887	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
216597003888	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
216597003889	homodimer interface [polypeptide binding]; other site
216597003890	NAD binding pocket [chemical binding]; other site
216597003891	ATP binding pocket [chemical binding]; other site
216597003892	Mg binding site [ion binding]; other site
216597003893	active-site loop [active]
216597003894	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
216597003895	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
216597003896	active site
216597003897	P-loop; other site
216597003898	phosphorylation site [posttranslational modification]
216597003899	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
216597003900	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
216597003901	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
216597003902	methionine cluster; other site
216597003903	active site
216597003904	phosphorylation site [posttranslational modification]
216597003905	metal binding site [ion binding]; metal-binding site
216597003906	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
216597003907	Cupin domain; Region: Cupin_2; pfam07883
216597003908	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597003909	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
216597003910	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
216597003911	NAD binding site [chemical binding]; other site
216597003912	sugar binding site [chemical binding]; other site
216597003913	divalent metal binding site [ion binding]; other site
216597003914	tetramer (dimer of dimers) interface [polypeptide binding]; other site
216597003915	dimer interface [polypeptide binding]; other site
216597003916	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
216597003917	putative active site [active]
216597003918	YdjC motif; other site
216597003919	Mg binding site [ion binding]; other site
216597003920	putative homodimer interface [polypeptide binding]; other site
216597003921	hydroperoxidase II; Provisional; Region: katE; PRK11249
216597003922	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
216597003923	tetramer interface [polypeptide binding]; other site
216597003924	heme binding pocket [chemical binding]; other site
216597003925	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
216597003926	domain interactions; other site
216597003927	cell division modulator; Provisional; Region: PRK10113
216597003928	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
216597003929	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216597003930	inner membrane protein; Provisional; Region: PRK11648
216597003931	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
216597003932	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
216597003933	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597003934	motif II; other site
216597003935	YniB-like protein; Region: YniB; pfam14002
216597003936	Phosphotransferase enzyme family; Region: APH; pfam01636
216597003937	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
216597003938	active site
216597003939	ATP binding site [chemical binding]; other site
216597003940	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
216597003941	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
216597003942	6-phosphofructokinase 2; Provisional; Region: PRK10294
216597003943	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
216597003944	putative substrate binding site [chemical binding]; other site
216597003945	putative ATP binding site [chemical binding]; other site
216597003946	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
216597003947	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528
216597003948	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
216597003949	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
216597003950	active site
216597003951	substrate binding site [chemical binding]; other site
216597003952	Mg2+ binding site [ion binding]; other site
216597003953	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
216597003954	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
216597003955	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
216597003956	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
216597003957	active site
216597003958	dimer interface [polypeptide binding]; other site
216597003959	motif 1; other site
216597003960	motif 2; other site
216597003961	motif 3; other site
216597003962	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
216597003963	anticodon binding site; other site
216597003964	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
216597003965	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
216597003966	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
216597003967	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
216597003968	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
216597003969	23S rRNA binding site [nucleotide binding]; other site
216597003970	L21 binding site [polypeptide binding]; other site
216597003971	L13 binding site [polypeptide binding]; other site
216597003972	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
216597003973	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
216597003974	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
216597003975	dimer interface [polypeptide binding]; other site
216597003976	motif 1; other site
216597003977	active site
216597003978	motif 2; other site
216597003979	motif 3; other site
216597003980	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
216597003981	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
216597003982	putative tRNA-binding site [nucleotide binding]; other site
216597003983	B3/4 domain; Region: B3_4; pfam03483
216597003984	tRNA synthetase B5 domain; Region: B5; smart00874
216597003985	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
216597003986	dimer interface [polypeptide binding]; other site
216597003987	motif 1; other site
216597003988	motif 3; other site
216597003989	motif 2; other site
216597003990	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
216597003991	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
216597003992	IHF dimer interface [polypeptide binding]; other site
216597003993	IHF - DNA interface [nucleotide binding]; other site
216597003994	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
216597003995	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216597003996	ABC-ATPase subunit  interface; other site
216597003997	dimer interface [polypeptide binding]; other site
216597003998	putative PBP binding regions; other site
216597003999	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
216597004000	catalytic residues [active]
216597004001	dimer interface [polypeptide binding]; other site
216597004002	ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138
216597004003	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
216597004004	Walker A/P-loop; other site
216597004005	ATP binding site [chemical binding]; other site
216597004006	Q-loop/lid; other site
216597004007	ABC transporter signature motif; other site
216597004008	Walker B; other site
216597004009	D-loop; other site
216597004010	H-loop/switch region; other site
216597004011	NlpC/P60 family; Region: NLPC_P60; pfam00877
216597004012	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
216597004013	Uncharacterized conserved protein [Function unknown]; Region: COG0397
216597004014	hypothetical protein; Validated; Region: PRK00029
216597004015	Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256
216597004016	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
216597004017	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
216597004018	PEP synthetase regulatory protein; Provisional; Region: PRK05339
216597004019	phosphoenolpyruvate synthase; Validated; Region: PRK06464
216597004020	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
216597004021	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
216597004022	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
216597004023	absent from CT18
216597004024	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
216597004025	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
216597004026	acyl-activating enzyme (AAE) consensus motif; other site
216597004027	putative AMP binding site [chemical binding]; other site
216597004028	putative active site [active]
216597004029	putative CoA binding site [chemical binding]; other site
216597004030	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
216597004031	oxidoreductase; Provisional; Region: PRK10015
216597004032	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
216597004033	Electron transfer flavoprotein domain; Region: ETF; smart00893
216597004034	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
216597004035	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
216597004036	Ligand binding site [chemical binding]; other site
216597004037	Electron transfer flavoprotein domain; Region: ETF; pfam01012
216597004038	Cupin domain; Region: Cupin_2; pfam07883
216597004039	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216597004040	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597004041	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
216597004042	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
216597004043	active site
216597004044	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
216597004045	Coenzyme A transferase; Region: CoA_trans; smart00882
216597004046	Coenzyme A transferase; Region: CoA_trans; cl17247
216597004047	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
216597004048	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
216597004049	active site
216597004050	catalytic residue [active]
216597004051	dimer interface [polypeptide binding]; other site
216597004052	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
216597004053	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
216597004054	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
216597004055	shikimate binding site; other site
216597004056	NAD(P) binding site [chemical binding]; other site
216597004058	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597004059	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216597004060	putative substrate translocation pore; other site
216597004061	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
216597004062	putative inner membrane protein; Provisional; Region: PRK10983
216597004063	Domain of unknown function DUF20; Region: UPF0118; pfam01594
216597004064	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
216597004065	FAD binding domain; Region: FAD_binding_4; pfam01565
216597004066	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
216597004067	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
216597004068	CoenzymeA binding site [chemical binding]; other site
216597004069	subunit interaction site [polypeptide binding]; other site
216597004070	PHB binding site; other site
216597004071	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
216597004072	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216597004073	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
216597004074	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
216597004075	putative ABC transporter; Region: ycf24; CHL00085
216597004076	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
216597004077	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
216597004078	Walker A/P-loop; other site
216597004079	ATP binding site [chemical binding]; other site
216597004080	Q-loop/lid; other site
216597004081	ABC transporter signature motif; other site
216597004082	Walker B; other site
216597004083	D-loop; other site
216597004084	H-loop/switch region; other site
216597004085	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
216597004086	FeS assembly protein SufD; Region: sufD; TIGR01981
216597004087	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
216597004088	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
216597004089	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216597004090	catalytic residue [active]
216597004091	cysteine desufuration protein SufE; Provisional; Region: PRK09296
216597004092	L,D-transpeptidase; Provisional; Region: PRK10190
216597004093	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216597004094	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
216597004095	murein lipoprotein; Provisional; Region: PRK15396
216597004096	murein lipoprotein; Provisional; Region: PRK15396
216597004097	pyruvate kinase; Provisional; Region: PRK09206
216597004098	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
216597004099	active site
216597004100	domain interfaces; other site
216597004101	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
216597004102	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
216597004103	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
216597004104	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
216597004105	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
216597004106	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216597004107	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
216597004108	substrate binding site [chemical binding]; other site
216597004109	dimer interface [polypeptide binding]; other site
216597004110	ATP binding site [chemical binding]; other site
216597004111	tetrathionate reductase subunit A; Provisional; Region: PRK14991
216597004112	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
216597004113	putative [Fe4-S4] binding site [ion binding]; other site
216597004114	putative molybdopterin cofactor binding site [chemical binding]; other site
216597004115	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
216597004116	putative molybdopterin cofactor binding site; other site
216597004117	tetrathionate reductase subunit C; Provisional; Region: PRK14992
216597004118	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
216597004119	tetrathionate reductase subunit B; Provisional; Region: PRK14993
216597004120	4Fe-4S binding domain; Region: Fer4; pfam00037
216597004121	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
216597004122	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
216597004123	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216597004124	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597004125	dimer interface [polypeptide binding]; other site
216597004126	phosphorylation site [posttranslational modification]
216597004127	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597004128	ATP binding site [chemical binding]; other site
216597004129	Mg2+ binding site [ion binding]; other site
216597004130	G-X-G motif; other site
216597004131	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
216597004132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597004133	active site
216597004134	phosphorylation site [posttranslational modification]
216597004135	intermolecular recognition site; other site
216597004136	dimerization interface [polypeptide binding]; other site
216597004137	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597004138	DNA binding residues [nucleotide binding]
216597004139	dimerization interface [polypeptide binding]; other site
216597004140	hypothetical protein; Provisional; Region: PRK10292
216597004141	Uncharacterized conserved protein [Function unknown]; Region: COG1683
216597004142	Uncharacterized conserved protein [Function unknown]; Region: COG3272
216597004143	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
216597004144	transcriptional regulator MirA; Provisional; Region: PRK15043
216597004145	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
216597004146	DNA binding residues [nucleotide binding]
216597004147	two component system sensor kinase SsrB; Provisional; Region: PRK15369
216597004148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597004149	active site
216597004150	phosphorylation site [posttranslational modification]
216597004151	intermolecular recognition site; other site
216597004152	dimerization interface [polypeptide binding]; other site
216597004153	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597004154	DNA binding residues [nucleotide binding]
216597004155	dimerization interface [polypeptide binding]; other site
216597004156	two component system sensor kinase SsrA; Provisional; Region: PRK15347
216597004157	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597004158	dimerization interface [polypeptide binding]; other site
216597004159	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597004160	dimer interface [polypeptide binding]; other site
216597004161	phosphorylation site [posttranslational modification]
216597004162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597004163	ATP binding site [chemical binding]; other site
216597004164	Mg2+ binding site [ion binding]; other site
216597004165	G-X-G motif; other site
216597004166	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597004167	active site
216597004168	phosphorylation site [posttranslational modification]
216597004169	intermolecular recognition site; other site
216597004170	dimerization interface [polypeptide binding]; other site
216597004171	pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368
216597004172	outer membrane secretin SsaC; Provisional; Region: PRK15346
216597004173	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216597004174	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
216597004175	type III secretion system protein SsaD; Provisional; Region: PRK15367
216597004176	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
216597004177	type III secretion system chaperone SsaE; Provisional; Region: PRK15366
216597004178	type III secretion system chaperone SseA; Provisional; Region: PRK15365
216597004179	pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364
216597004180	pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363
216597004181	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
216597004182	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
216597004183	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
216597004184	type III secretion system chaperone protein SscB; Provisional; Region: PRK15359
216597004185	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216597004186	TPR motif; other site
216597004187	binding surface
216597004188	pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358
216597004189	pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357
216597004190	type III secretion system needle protein SsaG; Provisional; Region: PRK15344
216597004191	type III secretion system protein SsaH; Provisional; Region: PRK15356
216597004192	type III secretion system protein SsaI; Provisional; Region: PRK15355
216597004193	type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348
216597004194	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
216597004195	type III secretion system protein SsaK; Provisional; Region: PRK15354
216597004196	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
216597004197	type III secretion system protein SsaL; Provisional; Region: PRK15345
216597004198	HrpJ-like domain; Region: HrpJ; pfam07201
216597004199	TyeA; Region: TyeA; cl07611
216597004200	type III secretion system protein SsaM; Provisional; Region: PRK15353
216597004201	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
216597004202	FHIPEP family; Region: FHIPEP; pfam00771
216597004203	type III secretion system ATPase SsaN; Validated; Region: PRK07594
216597004204	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216597004205	Walker A motif; other site
216597004206	ATP binding site [chemical binding]; other site
216597004207	Walker B motif; other site
216597004208	type III secretion system protein SsaO; Provisional; Region: PRK15352
216597004209	type III secretion system protein SsaP; Provisional; Region: PRK15351
216597004210	type III secretion system protein SsaQ; Validated; Region: PRK08035
216597004211	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
216597004212	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
216597004213	Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790
216597004214	type III secretion system protein SsaS; Provisional; Region: PRK15350
216597004215	type III secretion system protein SsaT; Provisional; Region: PRK15349
216597004216	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
216597004217	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
216597004218	multidrug efflux protein; Reviewed; Region: PRK01766
216597004219	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
216597004220	cation binding site [ion binding]; other site
216597004221	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
216597004222	Lumazine binding domain; Region: Lum_binding; pfam00677
216597004223	Lumazine binding domain; Region: Lum_binding; pfam00677
216597004224	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
216597004225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597004226	S-adenosylmethionine binding site [chemical binding]; other site
216597004227	putative transporter; Provisional; Region: PRK11043
216597004228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597004229	putative substrate translocation pore; other site
216597004230	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
216597004231	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597004232	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216597004233	dimerization interface [polypeptide binding]; other site
216597004234	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
216597004235	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597004236	DNA binding site [nucleotide binding]
216597004237	domain linker motif; other site
216597004238	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
216597004239	dimerization interface [polypeptide binding]; other site
216597004240	ligand binding site [chemical binding]; other site
216597004241	superoxide dismutase; Provisional; Region: PRK10543
216597004242	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
216597004243	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
216597004244	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
216597004245	NlpC/P60 family; Region: NLPC_P60; pfam00877
216597004246	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
216597004247	putative GSH binding site [chemical binding]; other site
216597004248	catalytic residues [active]
216597004249	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
216597004250	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
216597004251	dimer interface [polypeptide binding]; other site
216597004252	catalytic site [active]
216597004253	putative active site [active]
216597004254	putative substrate binding site [chemical binding]; other site
216597004255	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216597004256	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
216597004257	dimer interface [polypeptide binding]; other site
216597004258	active site
216597004259	metal binding site [ion binding]; metal-binding site
216597004260	glutathione binding site [chemical binding]; other site
216597004261	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216597004262	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
216597004263	FMN binding site [chemical binding]; other site
216597004264	active site
216597004265	substrate binding site [chemical binding]; other site
216597004266	catalytic residue [active]
216597004267	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216597004268	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597004269	Predicted Fe-S protein [General function prediction only]; Region: COG3313
216597004270	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216597004271	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216597004272	active site
216597004273	catalytic tetrad [active]
216597004274	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
216597004275	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
216597004276	E-class dimer interface [polypeptide binding]; other site
216597004277	P-class dimer interface [polypeptide binding]; other site
216597004278	active site
216597004279	Cu2+ binding site [ion binding]; other site
216597004280	Zn2+ binding site [ion binding]; other site
216597004281	Fusaric acid resistance protein family; Region: FUSC; pfam04632
216597004282	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
216597004283	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
216597004284	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216597004285	HlyD family secretion protein; Region: HlyD_3; pfam13437
216597004286	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
216597004287	transcriptional regulator SlyA; Provisional; Region: PRK03573
216597004288	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
216597004289	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
216597004290	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
216597004291	lysozyme inhibitor; Provisional; Region: PRK11372
216597004292	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
216597004293	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
216597004294	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
216597004295	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
216597004296	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
216597004297	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
216597004298	active site
216597004299	HIGH motif; other site
216597004300	dimer interface [polypeptide binding]; other site
216597004301	KMSKS motif; other site
216597004302	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216597004303	RNA binding surface [nucleotide binding]; other site
216597004304	pyridoxamine kinase; Validated; Region: PRK05756
216597004305	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
216597004306	dimer interface [polypeptide binding]; other site
216597004307	pyridoxal binding site [chemical binding]; other site
216597004308	ATP binding site [chemical binding]; other site
216597004309	glutathionine S-transferase; Provisional; Region: PRK10542
216597004310	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
216597004311	C-terminal domain interface [polypeptide binding]; other site
216597004312	GSH binding site (G-site) [chemical binding]; other site
216597004313	dimer interface [polypeptide binding]; other site
216597004314	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
216597004315	dimer interface [polypeptide binding]; other site
216597004316	N-terminal domain interface [polypeptide binding]; other site
216597004317	substrate binding pocket (H-site) [chemical binding]; other site
216597004318	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
216597004319	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597004320	putative substrate translocation pore; other site
216597004321	POT family; Region: PTR2; pfam00854
216597004322	endonuclease III; Provisional; Region: PRK10702
216597004323	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
216597004324	minor groove reading motif; other site
216597004325	helix-hairpin-helix signature motif; other site
216597004326	substrate binding pocket [chemical binding]; other site
216597004327	active site
216597004328	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
216597004329	electron transport complex RsxE subunit; Provisional; Region: PRK12405
216597004330	electron transport complex protein RnfG; Validated; Region: PRK01908
216597004331	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
216597004332	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
216597004333	SLBB domain; Region: SLBB; pfam10531
216597004334	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
216597004335	electron transport complex protein RnfB; Provisional; Region: PRK05113
216597004336	Putative Fe-S cluster; Region: FeS; cl17515
216597004337	4Fe-4S binding domain; Region: Fer4; pfam00037
216597004338	electron transport complex protein RsxA; Provisional; Region: PRK05151
216597004339	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
216597004340	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
216597004341	putative oxidoreductase; Provisional; Region: PRK11579
216597004342	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216597004343	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
216597004344	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
216597004345	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
216597004346	active site
216597004347	purine riboside binding site [chemical binding]; other site
216597004348	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
216597004349	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
216597004350	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
216597004351	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
216597004352	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
216597004353	fumarate hydratase; Provisional; Region: PRK15389
216597004354	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
216597004355	Fumarase C-terminus; Region: Fumerase_C; pfam05683
216597004356	fumarate hydratase; Reviewed; Region: fumC; PRK00485
216597004357	Class II fumarases; Region: Fumarase_classII; cd01362
216597004358	active site
216597004359	tetramer interface [polypeptide binding]; other site
216597004360	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
216597004361	sensor protein RstB; Provisional; Region: PRK10604
216597004362	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597004363	dimerization interface [polypeptide binding]; other site
216597004364	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597004365	dimer interface [polypeptide binding]; other site
216597004366	phosphorylation site [posttranslational modification]
216597004367	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597004368	ATP binding site [chemical binding]; other site
216597004369	Mg2+ binding site [ion binding]; other site
216597004370	G-X-G motif; other site
216597004371	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
216597004372	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
216597004373	active site
216597004374	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
216597004375	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
216597004376	trimer interface [polypeptide binding]; other site
216597004377	eyelet of channel; other site
216597004378	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
216597004379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597004380	active site
216597004381	phosphorylation site [posttranslational modification]
216597004382	intermolecular recognition site; other site
216597004383	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597004384	DNA binding site [nucleotide binding]
216597004385	GlpM protein; Region: GlpM; pfam06942
216597004386	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
216597004387	Spore germination protein; Region: Spore_permease; cl17796
216597004388	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
216597004389	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
216597004390	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
216597004391	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
216597004392	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
216597004393	ligand binding site [chemical binding]; other site
216597004394	homodimer interface [polypeptide binding]; other site
216597004395	NAD(P) binding site [chemical binding]; other site
216597004396	trimer interface B [polypeptide binding]; other site
216597004397	trimer interface A [polypeptide binding]; other site
216597004398	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
216597004399	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
216597004400	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
216597004401	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
216597004402	Domain of unknown function DUF20; Region: UPF0118; pfam01594
216597004403	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
216597004404	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
216597004405	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
216597004406	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
216597004407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597004408	putative substrate translocation pore; other site
216597004409	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
216597004410	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597004411	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
216597004412	dimerization interface [polypeptide binding]; other site
216597004413	substrate binding pocket [chemical binding]; other site
216597004414	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
216597004415	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
216597004416	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
216597004417	putative dithiobiotin synthetase; Provisional; Region: PRK12374
216597004418	AAA domain; Region: AAA_26; pfam13500
216597004419	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
216597004420	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
216597004421	Cl- selectivity filter; other site
216597004422	Cl- binding residues [ion binding]; other site
216597004423	pore gating glutamate residue; other site
216597004424	dimer interface [polypeptide binding]; other site
216597004425	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
216597004426	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
216597004427	Walker A/P-loop; other site
216597004428	ATP binding site [chemical binding]; other site
216597004429	Q-loop/lid; other site
216597004430	ABC transporter signature motif; other site
216597004431	Walker B; other site
216597004432	D-loop; other site
216597004433	H-loop/switch region; other site
216597004434	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
216597004435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597004436	dimer interface [polypeptide binding]; other site
216597004437	conserved gate region; other site
216597004438	ABC-ATPase subunit interface; other site
216597004439	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
216597004440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597004441	dimer interface [polypeptide binding]; other site
216597004442	conserved gate region; other site
216597004443	putative PBP binding loops; other site
216597004444	ABC-ATPase subunit interface; other site
216597004445	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
216597004446	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
216597004447	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
216597004448	4Fe-4S binding domain; Region: Fer4; pfam00037
216597004449	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
216597004450	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
216597004451	putative [Fe4-S4] binding site [ion binding]; other site
216597004452	putative molybdopterin cofactor binding site [chemical binding]; other site
216597004453	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
216597004454	putative molybdopterin cofactor binding site; other site
216597004455	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
216597004456	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
216597004457	putative [Fe4-S4] binding site [ion binding]; other site
216597004458	putative molybdopterin cofactor binding site [chemical binding]; other site
216597004459	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
216597004460	putative molybdopterin cofactor binding site; other site
216597004461	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
216597004462	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
216597004463	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
216597004464	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597004465	Coenzyme A binding pocket [chemical binding]; other site
216597004466	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
216597004467	hypothetical protein; Provisional; Region: PRK13659
216597004468	hypothetical protein; Provisional; Region: PRK02237
216597004469	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
216597004470	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
216597004471	putative active site pocket [active]
216597004472	putative metal binding site [ion binding]; other site
216597004473	putative oxidoreductase; Provisional; Region: PRK10083
216597004474	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
216597004475	putative NAD(P) binding site [chemical binding]; other site
216597004476	catalytic Zn binding site [ion binding]; other site
216597004477	structural Zn binding site [ion binding]; other site
216597004479	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
216597004480	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
216597004481	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
216597004482	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
216597004483	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216597004484	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597004485	DNA-binding site [nucleotide binding]; DNA binding site
216597004486	FCD domain; Region: FCD; pfam07729
216597004487	malonic semialdehyde reductase; Provisional; Region: PRK10538
216597004488	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
216597004489	putative NAD(P) binding site [chemical binding]; other site
216597004490	homodimer interface [polypeptide binding]; other site
216597004491	homotetramer interface [polypeptide binding]; other site
216597004492	active site
216597004493	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
216597004494	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
216597004495	active site
216597004496	Zn binding site [ion binding]; other site
216597004497	General stress protein [General function prediction only]; Region: GsiB; COG3729
216597004498	hypothetical protein; Validated; Region: PRK03657
216597004499	hypothetical protein; Provisional; Region: PRK10053
216597004500	putative transporter; Provisional; Region: PRK10054
216597004501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597004502	putative substrate translocation pore; other site
216597004503	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
216597004504	EamA-like transporter family; Region: EamA; pfam00892
216597004505	MarB protein; Region: MarB; pfam13999
216597004506	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
216597004507	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597004508	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597004509	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
216597004510	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216597004511	inner membrane protein; Provisional; Region: PRK10995
216597004512	putative arabinose transporter; Provisional; Region: PRK03545
216597004513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597004514	putative substrate translocation pore; other site
216597004515	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597004516	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597004517	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
216597004518	putative dimerization interface [polypeptide binding]; other site
216597004519	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
216597004520	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
216597004521	NAD(P) binding site [chemical binding]; other site
216597004522	catalytic residues [active]
216597004523	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
216597004524	glutaminase; Provisional; Region: PRK00971
216597004525	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
216597004526	Predicted membrane protein [Function unknown]; Region: COG3781
216597004527	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
216597004528	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
216597004529	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
216597004530	eyelet of channel; other site
216597004531	trimer interface [polypeptide binding]; other site
216597004532	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
216597004533	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
216597004534	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
216597004535	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
216597004536	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
216597004537	Rubredoxin [Energy production and conversion]; Region: COG1773
216597004538	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
216597004539	iron binding site [ion binding]; other site
216597004540	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
216597004541	HupF/HypC family; Region: HupF_HypC; cl00394
216597004542	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
216597004543	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
216597004544	putative substrate-binding site; other site
216597004545	nickel binding site [ion binding]; other site
216597004546	Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969
216597004547	hydrogenase 1 large subunit; Provisional; Region: PRK10170
216597004548	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
216597004549	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
216597004550	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
216597004551	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
216597004552	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
216597004553	active site
216597004554	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216597004555	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597004556	DNA-binding site [nucleotide binding]; DNA binding site
216597004557	FCD domain; Region: FCD; pfam07729
216597004558	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
216597004559	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
216597004560	putative NAD(P) binding site [chemical binding]; other site
216597004561	catalytic Zn binding site [ion binding]; other site
216597004562	structural Zn binding site [ion binding]; other site
216597004563	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597004564	D-galactonate transporter; Region: 2A0114; TIGR00893
216597004565	putative substrate translocation pore; other site
216597004566	PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287
216597004567	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597004568	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216597004569	putative substrate translocation pore; other site
216597004570	hypothetical protein; Provisional; Region: PRK06184
216597004571	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
216597004572	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
216597004573	Transcriptional regulators [Transcription]; Region: MarR; COG1846
216597004574	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216597004575	putative DNA binding site [nucleotide binding]; other site
216597004576	putative Zn2+ binding site [ion binding]; other site
216597004577	S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809
216597004578	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
216597004579	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
216597004580	homotrimer interaction site [polypeptide binding]; other site
216597004581	putative active site [active]
216597004582	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
216597004583	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
216597004584	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
216597004586	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216597004587	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597004588	DNA binding site [nucleotide binding]
216597004589	domain linker motif; other site
216597004590	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
216597004591	dimerization interface (closed form) [polypeptide binding]; other site
216597004592	ligand binding site [chemical binding]; other site
216597004593	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
216597004594	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
216597004595	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216597004596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597004597	homodimer interface [polypeptide binding]; other site
216597004598	catalytic residue [active]
216597004599	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
216597004600	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
216597004601	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
216597004602	active site
216597004603	catalytic site [active]
216597004604	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
216597004605	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
216597004606	active site
216597004607	catalytic site [active]
216597004608	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
216597004609	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
216597004610	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
216597004611	catalytic site [active]
216597004612	active site
216597004613	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
216597004614	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
216597004615	acid-resistance protein; Provisional; Region: hdeB; PRK11566
216597004616	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
216597004617	biofilm-dependent modulation protein; Provisional; Region: PRK11436
216597004618	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
216597004619	malate dehydrogenase; Provisional; Region: PRK13529
216597004620	Malic enzyme, N-terminal domain; Region: malic; pfam00390
216597004621	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
216597004622	NAD(P) binding site [chemical binding]; other site
216597004623	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
216597004624	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
216597004625	NAD binding site [chemical binding]; other site
216597004626	substrate binding site [chemical binding]; other site
216597004627	catalytic Zn binding site [ion binding]; other site
216597004628	tetramer interface [polypeptide binding]; other site
216597004629	structural Zn binding site [ion binding]; other site
216597004630	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
216597004631	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
216597004632	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
216597004633	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
216597004634	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
216597004635	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
216597004636	[4Fe-4S] binding site [ion binding]; other site
216597004637	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
216597004638	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
216597004639	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
216597004640	molybdopterin cofactor binding site; other site
216597004641	aromatic amino acid exporter; Provisional; Region: PRK11689
216597004642	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
216597004643	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
216597004644	trimer interface [polypeptide binding]; other site
216597004645	eyelet of channel; other site
216597004646	Uncharacterized conserved protein [Function unknown]; Region: COG3791
216597004647	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
216597004648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597004649	putative substrate translocation pore; other site
216597004650	TetR family transcriptional regulator; Provisional; Region: PRK14996
216597004651	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597004652	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
216597004653	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
216597004654	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
216597004655	[4Fe-4S] binding site [ion binding]; other site
216597004656	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
216597004657	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
216597004658	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
216597004659	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
216597004660	molybdopterin cofactor binding site; other site
216597004661	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
216597004662	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
216597004663	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
216597004664	hypothetical protein; Provisional; Region: PRK10281
216597004665	N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047
216597004666	L-asparagine permease; Provisional; Region: PRK15049
216597004667	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
216597004668	Uncharacterized conserved protein [Function unknown]; Region: COG3391
216597004669	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
216597004670	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
216597004671	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216597004672	N-terminal plug; other site
216597004673	ligand-binding site [chemical binding]; other site
216597004674	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
216597004675	DNA-binding site [nucleotide binding]; DNA binding site
216597004676	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
216597004677	FCD domain; Region: FCD; pfam07729
216597004678	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
216597004679	Prostaglandin dehydrogenases; Region: PGDH; cd05288
216597004680	NAD(P) binding site [chemical binding]; other site
216597004681	substrate binding site [chemical binding]; other site
216597004682	dimer interface [polypeptide binding]; other site
216597004683	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
216597004684	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
216597004685	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
216597004686	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
216597004687	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457
216597004688	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458
216597004689	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
216597004690	1-pyrroline dehydrogenase; Region: ABALDH; TIGR03374
216597004691	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
216597004692	tetrameric interface [polypeptide binding]; other site
216597004693	NAD binding site [chemical binding]; other site
216597004694	catalytic residues [active]
216597004695	substrate binding site [chemical binding]; other site
216597004696	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
216597004697	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597004698	DNA-binding site [nucleotide binding]; DNA binding site
216597004699	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216597004700	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597004701	homodimer interface [polypeptide binding]; other site
216597004702	catalytic residue [active]
216597004703	D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173
216597004704	secreted effector protein SifB; Provisional; Region: sifB; PRK09499
216597004705	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
216597004706	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
216597004707	Peptidase family U32; Region: Peptidase_U32; pfam01136
216597004708	Collagenase; Region: DUF3656; pfam12392
216597004709	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216597004710	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597004711	non-specific DNA binding site [nucleotide binding]; other site
216597004712	salt bridge; other site
216597004713	sequence-specific DNA binding site [nucleotide binding]; other site
216597004714	Cupin domain; Region: Cupin_2; pfam07883
216597004715	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
216597004716	benzoate transporter; Region: benE; TIGR00843
216597004717	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
216597004718	tellurite resistance protein TehB; Provisional; Region: PRK11207
216597004719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597004720	S-adenosylmethionine binding site [chemical binding]; other site
216597004721	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
216597004722	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
216597004723	gating phenylalanine in ion channel; other site
216597004724	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
216597004725	putative trimer interface [polypeptide binding]; other site
216597004726	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
216597004727	putative trimer interface [polypeptide binding]; other site
216597004728	putative CoA binding site [chemical binding]; other site
216597004729	putative CoA binding site [chemical binding]; other site
216597004730	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
216597004731	putative trimer interface [polypeptide binding]; other site
216597004732	putative CoA binding site [chemical binding]; other site
216597004733	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
216597004734	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597004735	Coenzyme A binding pocket [chemical binding]; other site
216597004736	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
216597004737	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
216597004738	oligomer interface [polypeptide binding]; other site
216597004739	active site
216597004740	metal binding site [ion binding]; metal-binding site
216597004741	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
216597004742	active site
216597004743	P-loop; other site
216597004744	phosphorylation site [posttranslational modification]
216597004745	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
216597004746	PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827
216597004747	membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259
216597004748	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216597004749	active site
216597004750	phosphorylation site [posttranslational modification]
216597004751	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
216597004752	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
216597004753	substrate binding site [chemical binding]; other site
216597004754	hexamer interface [polypeptide binding]; other site
216597004755	metal binding site [ion binding]; metal-binding site
216597004756	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
216597004757	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
216597004758	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216597004759	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
216597004760	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597004761	Coenzyme A binding pocket [chemical binding]; other site
216597004762	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
216597004763	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
216597004764	teramer interface [polypeptide binding]; other site
216597004765	active site
216597004766	FMN binding site [chemical binding]; other site
216597004767	catalytic residues [active]
216597004768	Uncharacterized conserved protein [Function unknown]; Region: COG2353
216597004769	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
216597004770	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
216597004771	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
216597004772	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
216597004773	substrate binding pocket [chemical binding]; other site
216597004774	catalytic triad [active]
216597004775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
216597004776	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
216597004777	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
216597004778	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597004779	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216597004780	dimerization interface [polypeptide binding]; other site
216597004781	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
216597004782	dimer interface [polypeptide binding]; other site
216597004783	ligand binding site [chemical binding]; other site
216597004784	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
216597004785	HAMP domain; Region: HAMP; pfam00672
216597004786	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216597004787	dimer interface [polypeptide binding]; other site
216597004788	putative CheW interface [polypeptide binding]; other site
216597004789	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
216597004790	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
216597004791	substrate binding site [chemical binding]; other site
216597004792	catalytic Zn binding site [ion binding]; other site
216597004793	NAD binding site [chemical binding]; other site
216597004794	structural Zn binding site [ion binding]; other site
216597004795	dimer interface [polypeptide binding]; other site
216597004796	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
216597004797	putative metal binding site [ion binding]; other site
216597004798	putative homodimer interface [polypeptide binding]; other site
216597004799	putative homotetramer interface [polypeptide binding]; other site
216597004800	putative homodimer-homodimer interface [polypeptide binding]; other site
216597004801	putative allosteric switch controlling residues; other site
216597004802	Sif protein; Region: Sif; cl11505
216597004803	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
216597004804	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
216597004805	active site
216597004806	catalytic triad [active]
216597004807	oxyanion hole [active]
216597004808	Predicted membrane protein [Function unknown]; Region: COG3326
216597004809	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597004810	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216597004811	substrate binding pocket [chemical binding]; other site
216597004812	membrane-bound complex binding site; other site
216597004813	hinge residues; other site
216597004814	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216597004815	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597004816	dimer interface [polypeptide binding]; other site
216597004817	conserved gate region; other site
216597004818	putative PBP binding loops; other site
216597004819	ABC-ATPase subunit interface; other site
216597004820	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216597004821	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597004822	Walker A/P-loop; other site
216597004823	ATP binding site [chemical binding]; other site
216597004824	Q-loop/lid; other site
216597004825	ABC transporter signature motif; other site
216597004826	Walker B; other site
216597004827	D-loop; other site
216597004828	H-loop/switch region; other site
216597004829	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216597004830	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597004831	dimer interface [polypeptide binding]; other site
216597004832	conserved gate region; other site
216597004833	putative PBP binding loops; other site
216597004834	ABC-ATPase subunit interface; other site
216597004835	Predicted membrane protein [Function unknown]; Region: COG5305
216597004836	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
216597004837	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597004838	S-adenosylmethionine binding site [chemical binding]; other site
216597004839	cytochrome b561; Provisional; Region: PRK11513
216597004840	Uncharacterized conserved protein [Function unknown]; Region: COG1434
216597004841	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
216597004842	putative active site [active]
216597004843	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
216597004844	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216597004845	ATP binding site [chemical binding]; other site
216597004846	putative Mg++ binding site [ion binding]; other site
216597004847	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597004848	nucleotide binding region [chemical binding]; other site
216597004849	ATP-binding site [chemical binding]; other site
216597004850	Helicase associated domain (HA2); Region: HA2; pfam04408
216597004851	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
216597004852	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
216597004853	azoreductase; Reviewed; Region: PRK00170
216597004854	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
216597004855	Uncharacterized conserved protein [Function unknown]; Region: COG3791
216597004856	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
216597004857	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
216597004858	hypothetical protein; Provisional; Region: PRK10695
216597004859	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
216597004860	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
216597004861	putative ligand binding site [chemical binding]; other site
216597004862	putative NAD binding site [chemical binding]; other site
216597004863	catalytic site [active]
216597004864	heat-inducible protein; Provisional; Region: PRK10449
216597004865	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
216597004866	Domain of unknown function (DUF333); Region: DUF333; pfam03891
216597004867	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
216597004868	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
216597004869	dimer interface [polypeptide binding]; other site
216597004870	PYR/PP interface [polypeptide binding]; other site
216597004871	TPP binding site [chemical binding]; other site
216597004872	substrate binding site [chemical binding]; other site
216597004873	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
216597004874	Domain of unknown function; Region: EKR; smart00890
216597004875	4Fe-4S binding domain; Region: Fer4_6; pfam12837
216597004876	4Fe-4S binding domain; Region: Fer4; pfam00037
216597004877	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
216597004878	TPP-binding site [chemical binding]; other site
216597004879	dimer interface [polypeptide binding]; other site
216597004880	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216597004881	Ligand Binding Site [chemical binding]; other site
216597004882	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
216597004884	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
216597004885	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
216597004886	Ligand Binding Site [chemical binding]; other site
216597004887	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
216597004888	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
216597004889	ATP binding site [chemical binding]; other site
216597004890	Mg++ binding site [ion binding]; other site
216597004891	motif III; other site
216597004892	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597004893	nucleotide binding region [chemical binding]; other site
216597004894	ATP-binding site [chemical binding]; other site
216597004895	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
216597004896	putative RNA binding site [nucleotide binding]; other site
216597004897	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
216597004898	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
216597004899	Cl binding site [ion binding]; other site
216597004900	oligomer interface [polypeptide binding]; other site
216597004901	HAMP domain; Region: HAMP; pfam00672
216597004902	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216597004903	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216597004904	dimer interface [polypeptide binding]; other site
216597004905	putative CheW interface [polypeptide binding]; other site
216597004906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
216597004907	Smr domain; Region: Smr; pfam01713
216597004908	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
216597004909	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
216597004910	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
216597004911	DNA binding site [nucleotide binding]
216597004912	active site
216597004913	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
216597004914	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
216597004915	ligand binding site [chemical binding]; other site
216597004916	flexible hinge region; other site
216597004917	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
216597004918	putative switch regulator; other site
216597004919	non-specific DNA interactions [nucleotide binding]; other site
216597004920	DNA binding site [nucleotide binding]
216597004921	sequence specific DNA binding site [nucleotide binding]; other site
216597004922	putative cAMP binding site [chemical binding]; other site
216597004923	universal stress protein UspE; Provisional; Region: PRK11175
216597004924	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216597004925	Ligand Binding Site [chemical binding]; other site
216597004926	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216597004927	Ligand Binding Site [chemical binding]; other site
216597004928	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
216597004929	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
216597004930	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216597004931	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
216597004932	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597004933	non-specific DNA binding site [nucleotide binding]; other site
216597004934	salt bridge; other site
216597004935	sequence-specific DNA binding site [nucleotide binding]; other site
216597004936	Cupin domain; Region: Cupin_2; pfam07883
216597004937	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
216597004938	B3/4 domain; Region: B3_4; pfam03483
216597004939	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077
216597004940	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
216597004942	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
216597004943	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216597004944	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597004945	oxidoreductase; Provisional; Region: PRK12742
216597004946	classical (c) SDRs; Region: SDR_c; cd05233
216597004947	NAD(P) binding site [chemical binding]; other site
216597004948	active site
216597004949	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216597004950	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216597004951	active site
216597004952	catalytic tetrad [active]
216597004953	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597004954	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597004955	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
216597004956	putative effector binding pocket; other site
216597004957	putative dimerization interface [polypeptide binding]; other site
216597004958	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
216597004959	NmrA-like family; Region: NmrA; pfam05368
216597004960	NAD(P) binding site [chemical binding]; other site
216597004961	active site lysine
216597004962	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
216597004963	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
216597004964	peptide binding site [polypeptide binding]; other site
216597004965	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
216597004966	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
216597004967	putative active site [active]
216597004968	Zn binding site [ion binding]; other site
216597004969	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
216597004970	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
216597004971	active site
216597004972	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
216597004973	dimer interface [polypeptide binding]; other site
216597004974	catalytic triad [active]
216597004975	peroxidatic and resolving cysteines [active]
216597004976	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
216597004977	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
216597004978	putative aromatic amino acid binding site; other site
216597004979	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597004980	Walker A motif; other site
216597004981	ATP binding site [chemical binding]; other site
216597004982	Walker B motif; other site
216597004983	arginine finger; other site
216597004984	hypothetical protein; Provisional; Region: PRK05415
216597004985	TIGR01620 family protein; Region: hyp_HI0043
216597004986	Predicted ATPase [General function prediction only]; Region: COG3106
216597004987	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
216597004988	active site residue [active]
216597004989	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
216597004990	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
216597004991	phage shock protein C; Region: phageshock_pspC; TIGR02978
216597004992	phage shock protein B; Provisional; Region: pspB; PRK09458
216597004993	phage shock protein PspA; Provisional; Region: PRK10698
216597004994	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
216597004995	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597004996	Walker A motif; other site
216597004997	ATP binding site [chemical binding]; other site
216597004998	Walker B motif; other site
216597004999	arginine finger; other site
216597005000	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
216597005001	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
216597005002	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
216597005003	peptide binding site [polypeptide binding]; other site
216597005004	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
216597005005	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597005006	dimer interface [polypeptide binding]; other site
216597005007	conserved gate region; other site
216597005008	putative PBP binding loops; other site
216597005009	ABC-ATPase subunit interface; other site
216597005010	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
216597005011	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
216597005012	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597005013	dimer interface [polypeptide binding]; other site
216597005014	conserved gate region; other site
216597005015	putative PBP binding loops; other site
216597005016	ABC-ATPase subunit interface; other site
216597005017	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
216597005018	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216597005019	Walker A/P-loop; other site
216597005020	ATP binding site [chemical binding]; other site
216597005021	Q-loop/lid; other site
216597005022	ABC transporter signature motif; other site
216597005023	Walker B; other site
216597005024	D-loop; other site
216597005025	H-loop/switch region; other site
216597005026	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216597005027	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
216597005028	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216597005029	Walker A/P-loop; other site
216597005030	ATP binding site [chemical binding]; other site
216597005031	Q-loop/lid; other site
216597005032	ABC transporter signature motif; other site
216597005033	Walker B; other site
216597005034	D-loop; other site
216597005035	H-loop/switch region; other site
216597005036	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
216597005037	Protein kinase domain; Region: Pkinase; pfam00069
216597005038	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
216597005039	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
216597005040	NAD binding site [chemical binding]; other site
216597005041	homotetramer interface [polypeptide binding]; other site
216597005042	homodimer interface [polypeptide binding]; other site
216597005043	substrate binding site [chemical binding]; other site
216597005044	active site
216597005045	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950
216597005046	Uncharacterized conserved protein [Function unknown]; Region: COG2128
216597005047	exoribonuclease II; Provisional; Region: PRK05054
216597005048	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
216597005049	RNB domain; Region: RNB; pfam00773
216597005050	S1 RNA binding domain; Region: S1; pfam00575
216597005051	RNase II stability modulator; Provisional; Region: PRK10060
216597005052	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216597005053	putative active site [active]
216597005054	heme pocket [chemical binding]; other site
216597005055	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216597005056	metal binding site [ion binding]; metal-binding site
216597005057	active site
216597005058	I-site; other site
216597005059	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597005060	hypothetical protein; Provisional; Region: PRK13658
216597005061	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
216597005062	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
216597005063	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216597005064	lipoprotein; Provisional; Region: PRK10540
216597005065	translation initiation factor Sui1; Validated; Region: PRK06824
216597005066	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
216597005067	putative rRNA binding site [nucleotide binding]; other site
216597005068	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
216597005069	active site
216597005070	dimer interface [polypeptide binding]; other site
216597005071	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
216597005072	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
216597005073	TPR motif; other site
216597005074	binding surface
216597005075	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216597005076	binding surface
216597005077	TPR motif; other site
216597005078	Predicted membrane protein [Function unknown]; Region: COG3771
216597005079	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
216597005080	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
216597005081	active site
216597005082	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
216597005083	dimerization interface [polypeptide binding]; other site
216597005084	active site
216597005085	aconitate hydratase; Validated; Region: PRK09277
216597005086	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
216597005087	substrate binding site [chemical binding]; other site
216597005088	ligand binding site [chemical binding]; other site
216597005089	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
216597005090	substrate binding site [chemical binding]; other site
216597005091	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
216597005092	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597005093	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
216597005094	substrate binding site [chemical binding]; other site
216597005095	putative dimerization interface [polypeptide binding]; other site
216597005096	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
216597005097	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
216597005098	active site
216597005099	interdomain interaction site; other site
216597005100	putative metal-binding site [ion binding]; other site
216597005101	nucleotide binding site [chemical binding]; other site
216597005102	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
216597005103	domain I; other site
216597005104	DNA binding groove [nucleotide binding]
216597005105	phosphate binding site [ion binding]; other site
216597005106	domain II; other site
216597005107	domain III; other site
216597005108	nucleotide binding site [chemical binding]; other site
216597005109	catalytic site [active]
216597005110	domain IV; other site
216597005111	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
216597005112	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
216597005113	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
216597005114	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
216597005115	hypothetical protein; Provisional; Region: PRK11037
216597005116	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
216597005117	putative inner membrane peptidase; Provisional; Region: PRK11778
216597005118	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
216597005119	tandem repeat interface [polypeptide binding]; other site
216597005120	oligomer interface [polypeptide binding]; other site
216597005121	active site residues [active]
216597005122	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
216597005123	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
216597005124	NADP binding site [chemical binding]; other site
216597005125	homodimer interface [polypeptide binding]; other site
216597005126	active site
216597005127	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
216597005128	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
216597005129	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
216597005130	homodimer interface [polypeptide binding]; other site
216597005131	Walker A motif; other site
216597005132	ATP binding site [chemical binding]; other site
216597005133	hydroxycobalamin binding site [chemical binding]; other site
216597005134	Walker B motif; other site
216597005135	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
216597005136	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216597005137	RNA binding surface [nucleotide binding]; other site
216597005138	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
216597005139	probable active site [active]
216597005140	hypothetical protein; Provisional; Region: PRK11630
216597005141	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
216597005142	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
216597005143	active site
216597005144	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
216597005145	anthranilate synthase component I; Provisional; Region: PRK13564
216597005146	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
216597005147	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
216597005148	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
216597005149	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
216597005150	glutamine binding [chemical binding]; other site
216597005151	catalytic triad [active]
216597005152	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
216597005153	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
216597005154	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
216597005155	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
216597005156	active site
216597005157	ribulose/triose binding site [chemical binding]; other site
216597005158	phosphate binding site [ion binding]; other site
216597005159	substrate (anthranilate) binding pocket [chemical binding]; other site
216597005160	product (indole) binding pocket [chemical binding]; other site
216597005161	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
216597005162	active site
216597005163	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
216597005164	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
216597005165	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597005166	catalytic residue [active]
216597005167	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
216597005168	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
216597005169	substrate binding site [chemical binding]; other site
216597005170	active site
216597005171	catalytic residues [active]
216597005172	heterodimer interface [polypeptide binding]; other site
216597005173	General stress protein [General function prediction only]; Region: GsiB; COG3729
216597005174	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
216597005175	dimerization interface [polypeptide binding]; other site
216597005176	metal binding site [ion binding]; metal-binding site
216597005177	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
216597005178	dinuclear metal binding motif [ion binding]; other site
216597005179	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
216597005180	dimanganese center [ion binding]; other site
216597005181	outer membrane protein W; Provisional; Region: PRK10959
216597005182	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
216597005183	hypothetical protein; Provisional; Region: PRK02868
216597005184	intracellular septation protein A; Reviewed; Region: PRK00259
216597005185	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
216597005186	transport protein TonB; Provisional; Region: PRK10819
216597005187	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
216597005188	YciI-like protein; Reviewed; Region: PRK11370
216597005189	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
216597005190	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
216597005191	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
216597005192	putative active site [active]
216597005193	catalytic site [active]
216597005194	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
216597005195	putative active site [active]
216597005196	catalytic site [active]
216597005197	dsDNA-mimic protein; Reviewed; Region: PRK05094
216597005198	Ion transport protein; Region: Ion_trans; pfam00520
216597005199	Ion channel; Region: Ion_trans_2; pfam07885
216597005200	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
216597005201	Double zinc ribbon; Region: DZR; pfam12773
216597005202	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
216597005203	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216597005204	Walker A/P-loop; other site
216597005205	ATP binding site [chemical binding]; other site
216597005206	Q-loop/lid; other site
216597005207	ABC transporter signature motif; other site
216597005208	Walker B; other site
216597005209	D-loop; other site
216597005210	H-loop/switch region; other site
216597005211	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
216597005212	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
216597005213	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216597005214	Walker A/P-loop; other site
216597005215	ATP binding site [chemical binding]; other site
216597005216	Q-loop/lid; other site
216597005217	ABC transporter signature motif; other site
216597005218	Walker B; other site
216597005219	D-loop; other site
216597005220	H-loop/switch region; other site
216597005221	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216597005222	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
216597005223	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
216597005224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597005225	dimer interface [polypeptide binding]; other site
216597005226	conserved gate region; other site
216597005227	ABC-ATPase subunit interface; other site
216597005228	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
216597005229	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597005230	dimer interface [polypeptide binding]; other site
216597005231	conserved gate region; other site
216597005232	putative PBP binding loops; other site
216597005233	ABC-ATPase subunit interface; other site
216597005234	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
216597005235	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
216597005236	peptide binding site [polypeptide binding]; other site
216597005237	hypothetical protein; Provisional; Region: PRK11111
216597005238	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
216597005239	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
216597005240	putative catalytic cysteine [active]
216597005241	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
216597005242	putative active site [active]
216597005243	metal binding site [ion binding]; metal-binding site
216597005244	thymidine kinase; Provisional; Region: PRK04296
216597005245	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
216597005246	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
216597005247	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
216597005248	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
216597005249	active site
216597005250	tetramer interface; other site
216597005251	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597005252	active site
216597005253	response regulator of RpoS; Provisional; Region: PRK10693
216597005254	phosphorylation site [posttranslational modification]
216597005255	intermolecular recognition site; other site
216597005256	dimerization interface [polypeptide binding]; other site
216597005257	hypothetical protein; Provisional; Region: PRK10279
216597005258	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
216597005259	active site
216597005260	nucleophile elbow; other site
216597005261	SEC-C motif; Region: SEC-C; pfam02810
216597005262	hypothetical protein; Provisional; Region: PRK04233
216597005263	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
216597005264	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
216597005265	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
216597005266	putative active site [active]
216597005267	putative substrate binding site [chemical binding]; other site
216597005268	putative cosubstrate binding site; other site
216597005269	catalytic site [active]
216597005270	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
216597005271	Sel1-like repeats; Region: SEL1; smart00671
216597005272	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
216597005273	Sel1-like repeats; Region: SEL1; smart00671
216597005274	Sel1-like repeats; Region: SEL1; smart00671
216597005275	Sel1-like repeats; Region: SEL1; smart00671
216597005276	Sel1-like repeats; Region: SEL1; smart00671
216597005277	Sel1-like repeats; Region: SEL1; smart00671
216597005278	Sel1-like repeats; Region: SEL1; smart00671
216597005279	Sel1-like repeats; Region: SEL1; smart00671
216597005280	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
216597005281	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
216597005282	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
216597005283	4Fe-4S binding domain; Region: Fer4; cl02805
216597005284	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
216597005285	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
216597005286	[4Fe-4S] binding site [ion binding]; other site
216597005287	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
216597005288	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
216597005289	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
216597005290	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
216597005291	molybdopterin cofactor binding site; other site
216597005292	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
216597005293	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
216597005294	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
216597005295	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597005296	dimerization interface [polypeptide binding]; other site
216597005297	Histidine kinase; Region: HisKA_3; pfam07730
216597005298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597005299	ATP binding site [chemical binding]; other site
216597005300	Mg2+ binding site [ion binding]; other site
216597005301	G-X-G motif; other site
216597005302	transcriptional regulator NarL; Provisional; Region: PRK10651
216597005303	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597005304	active site
216597005305	phosphorylation site [posttranslational modification]
216597005306	intermolecular recognition site; other site
216597005307	dimerization interface [polypeptide binding]; other site
216597005308	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597005309	DNA binding residues [nucleotide binding]
216597005310	dimerization interface [polypeptide binding]; other site
216597005311	putative invasin; Provisional; Region: PRK10177
216597005312	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
216597005313	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
216597005314	cation transport regulator; Reviewed; Region: chaB; PRK09582
216597005315	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
216597005316	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
216597005317	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
216597005318	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
216597005319	hypothetical protein; Provisional; Region: PRK10941
216597005320	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
216597005321	hypothetical protein; Provisional; Region: PRK10278
216597005322	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
216597005323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597005324	peptide chain release factor 1; Validated; Region: prfA; PRK00591
216597005325	This domain is found in peptide chain release factors; Region: PCRF; smart00937
216597005326	RF-1 domain; Region: RF-1; pfam00472
216597005327	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
216597005328	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
216597005329	tRNA; other site
216597005330	putative tRNA binding site [nucleotide binding]; other site
216597005331	putative NADP binding site [chemical binding]; other site
216597005332	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
216597005333	Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017
216597005334	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
216597005335	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
216597005336	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
216597005337	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
216597005338	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
216597005339	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216597005340	active site
216597005341	putative transporter; Provisional; Region: PRK11660
216597005342	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
216597005343	Sulfate transporter family; Region: Sulfate_transp; pfam00916
216597005344	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
216597005345	hypothetical protein; Provisional; Region: PRK10692
216597005346	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
216597005347	putative active site [active]
216597005348	catalytic residue [active]
216597005349	GTP-binding protein YchF; Reviewed; Region: PRK09601
216597005350	YchF GTPase; Region: YchF; cd01900
216597005351	G1 box; other site
216597005352	GTP/Mg2+ binding site [chemical binding]; other site
216597005353	Switch I region; other site
216597005354	G2 box; other site
216597005355	Switch II region; other site
216597005356	G3 box; other site
216597005357	G4 box; other site
216597005358	G5 box; other site
216597005359	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
216597005360	Protein of unknown function (DUF2743); Region: DUF2743; pfam10899
216597005361	Protein of unknown function (DUF4427); Region: DUF4427; pfam14468
216597005362	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
216597005363	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
216597005364	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
216597005365	hydrogenase 1 large subunit; Provisional; Region: PRK10170
216597005366	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
216597005367	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
216597005368	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
216597005369	putative substrate-binding site; other site
216597005370	nickel binding site [ion binding]; other site
216597005371	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
216597005372	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
216597005373	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
216597005374	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
216597005375	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
216597005376	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
216597005377	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
216597005378	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
216597005379	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
216597005380	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
216597005381	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
216597005382	NAD(P) binding site [chemical binding]; other site
216597005383	trehalase; Provisional; Region: treA; PRK13271
216597005384	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
216597005385	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
216597005386	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
216597005387	Flagellar regulator YcgR; Region: YcgR; pfam07317
216597005388	PilZ domain; Region: PilZ; pfam07238
216597005389	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
216597005390	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216597005391	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216597005392	catalytic residue [active]
216597005393	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
216597005394	dimer interface [polypeptide binding]; other site
216597005395	catalytic triad [active]
216597005396	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
216597005397	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
216597005398	TrkA-C domain; Region: TrkA_C; pfam02080
216597005399	Transporter associated domain; Region: CorC_HlyC; smart01091
216597005400	alanine racemase; Reviewed; Region: dadX; PRK03646
216597005401	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
216597005402	active site
216597005403	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216597005404	substrate binding site [chemical binding]; other site
216597005405	catalytic residues [active]
216597005406	dimer interface [polypeptide binding]; other site
216597005407	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
216597005408	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216597005409	SpoVR family protein; Provisional; Region: PRK11767
216597005410	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
216597005411	fatty acid metabolism regulator; Provisional; Region: PRK04984
216597005412	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597005413	DNA-binding site [nucleotide binding]; DNA binding site
216597005414	FadR C-terminal domain; Region: FadR_C; pfam07840
216597005415	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
216597005416	transmembrane helices; other site
216597005417	disulfide bond formation protein B; Provisional; Region: PRK01749
216597005418	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
216597005419	GnsA/GnsB family; Region: GnsAB; pfam08178
216597005420	hypothetical protein; Provisional; Region: PRK05170
216597005421	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
216597005422	hypothetical protein; Provisional; Region: PRK10691
216597005423	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
216597005424	septum formation inhibitor; Reviewed; Region: minC; PRK03511
216597005425	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
216597005426	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
216597005427	cell division inhibitor MinD; Provisional; Region: PRK10818
216597005428	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
216597005429	Switch I; other site
216597005430	Switch II; other site
216597005431	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
216597005432	ribonuclease D; Provisional; Region: PRK10829
216597005433	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
216597005434	catalytic site [active]
216597005435	putative active site [active]
216597005436	putative substrate binding site [chemical binding]; other site
216597005437	HRDC domain; Region: HRDC; cl02578
216597005438	Transposase IS200 like; Region: Y1_Tnp; pfam01797
216597005439	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
216597005440	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
216597005441	acyl-activating enzyme (AAE) consensus motif; other site
216597005442	putative AMP binding site [chemical binding]; other site
216597005443	putative active site [active]
216597005444	putative CoA binding site [chemical binding]; other site
216597005445	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
216597005446	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
216597005447	Glycoprotease family; Region: Peptidase_M22; pfam00814
216597005448	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
216597005449	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
216597005450	DEAD_2; Region: DEAD_2; pfam06733
216597005451	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
216597005452	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
216597005453	homotrimer interaction site [polypeptide binding]; other site
216597005454	putative active site [active]
216597005455	hypothetical protein; Provisional; Region: PRK05114
216597005456	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
216597005457	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
216597005458	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
216597005459	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
216597005460	putative active site [active]
216597005461	putative CoA binding site [chemical binding]; other site
216597005462	nudix motif; other site
216597005463	metal binding site [ion binding]; metal-binding site
216597005464	L-serine deaminase; Provisional; Region: PRK15023
216597005465	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
216597005466	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
216597005467	phage resistance protein; Provisional; Region: PRK10551
216597005468	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
216597005469	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597005470	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
216597005471	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
216597005472	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
216597005473	Transporter associated domain; Region: CorC_HlyC; smart01091
216597005474	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
216597005475	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
216597005476	active pocket/dimerization site; other site
216597005477	active site
216597005478	phosphorylation site [posttranslational modification]
216597005479	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
216597005480	active site
216597005481	phosphorylation site [posttranslational modification]
216597005482	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
216597005483	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
216597005484	hypothetical protein; Provisional; Region: PRK02913
216597005485	hypothetical protein; Provisional; Region: PRK11469
216597005486	Domain of unknown function DUF; Region: DUF204; pfam02659
216597005487	Domain of unknown function DUF; Region: DUF204; pfam02659
216597005488	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
216597005489	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597005490	S-adenosylmethionine binding site [chemical binding]; other site
216597005491	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
216597005492	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
216597005493	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
216597005494	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
216597005495	DNA-binding site [nucleotide binding]; DNA binding site
216597005496	RNA-binding motif; other site
216597005497	Protein of unknown function (DUF2627); Region: DUF2527; pfam10736
216597005498	YebO-like protein; Region: YebO; pfam13974
216597005499	PhoPQ regulatory protein; Provisional; Region: PRK10299
216597005500	YobH-like protein; Region: YobH; pfam13996
216597005501	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
216597005502	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216597005503	dimerization interface [polypeptide binding]; other site
216597005504	putative Zn2+ binding site [ion binding]; other site
216597005505	putative DNA binding site [nucleotide binding]; other site
216597005506	Bacterial transcriptional regulator; Region: IclR; pfam01614
216597005507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597005508	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216597005509	putative substrate translocation pore; other site
216597005510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597005511	heat shock protein HtpX; Provisional; Region: PRK05457
216597005512	carboxy-terminal protease; Provisional; Region: PRK11186
216597005513	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
216597005514	protein binding site [polypeptide binding]; other site
216597005515	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
216597005516	Catalytic dyad [active]
216597005517	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
216597005518	ProP expression regulator; Provisional; Region: PRK04950
216597005519	ProQ/FINO family; Region: ProQ; pfam04352
216597005520	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
216597005521	GAF domain; Region: GAF_2; pfam13185
216597005522	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
216597005523	Paraquat-inducible protein A; Region: PqiA; pfam04403
216597005524	Paraquat-inducible protein A; Region: PqiA; pfam04403
216597005525	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
216597005526	mce related protein; Region: MCE; pfam02470
216597005527	mce related protein; Region: MCE; pfam02470
216597005528	mce related protein; Region: MCE; pfam02470
216597005529	mce related protein; Region: MCE; pfam02470
216597005530	mce related protein; Region: MCE; pfam02470
216597005531	mce related protein; Region: MCE; pfam02470
216597005532	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
216597005533	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
216597005534	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
216597005535	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
216597005536	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
216597005537	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
216597005538	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
216597005539	type III secretion protein SopE2; Provisional; Region: PRK15280
216597005540	Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364
216597005541	SopE GEF domain; Region: SopE_GEF; pfam07487
216597005542	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
216597005543	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597005544	Coenzyme A binding pocket [chemical binding]; other site
216597005549	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
216597005550	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216597005551	EamA-like transporter family; Region: EamA; pfam00892
216597005552	EamA-like transporter family; Region: EamA; pfam00892
216597005553	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
216597005556	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
216597005557	ADP-ribose binding site [chemical binding]; other site
216597005558	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
216597005559	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
216597005560	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
216597005563	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
216597005564	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
216597005565	dimer interface [polypeptide binding]; other site
216597005566	active site
216597005567	Int/Topo IB signature motif; other site
216597005568	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
216597005569	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
216597005570	hypothetical protein; Provisional; Region: PRK10301
216597005571	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
216597005572	Predicted amidohydrolase [General function prediction only]; Region: COG0388
216597005573	Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795
216597005574	exodeoxyribonuclease X; Provisional; Region: PRK07983
216597005575	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
216597005576	active site
216597005577	catalytic site [active]
216597005578	substrate binding site [chemical binding]; other site
216597005579	protease 2; Provisional; Region: PRK10115
216597005580	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216597005581	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
216597005582	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
216597005583	putative metal binding site [ion binding]; other site
216597005584	hypothetical protein; Provisional; Region: PRK13680
216597005585	DNA damage-inducible protein YebG; Provisional; Region: PRK10061
216597005586	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
216597005587	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216597005588	ATP-grasp domain; Region: ATP-grasp; pfam02222
216597005589	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
216597005590	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
216597005591	active site
216597005592	intersubunit interface [polypeptide binding]; other site
216597005593	catalytic residue [active]
216597005594	phosphogluconate dehydratase; Validated; Region: PRK09054
216597005595	6-phosphogluconate dehydratase; Region: edd; TIGR01196
216597005596	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
216597005597	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
216597005598	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
216597005599	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
216597005600	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
216597005601	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
216597005602	putative active site [active]
216597005603	pyruvate kinase; Provisional; Region: PRK05826
216597005604	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
216597005605	domain interfaces; other site
216597005606	active site
216597005607	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
216597005608	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
216597005609	putative acyl-acceptor binding pocket; other site
216597005610	putative peptidase; Provisional; Region: PRK11649
216597005611	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
216597005612	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216597005613	Peptidase family M23; Region: Peptidase_M23; pfam01551
216597005614	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
216597005615	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
216597005616	metal binding site [ion binding]; metal-binding site
216597005617	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
216597005618	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
216597005619	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
216597005620	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216597005621	ABC-ATPase subunit  interface; other site
216597005622	dimer interface [polypeptide binding]; other site
216597005623	putative PBP binding regions; other site
216597005624	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
216597005625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597005626	Walker A motif; other site
216597005627	ATP binding site [chemical binding]; other site
216597005628	Walker B motif; other site
216597005629	arginine finger; other site
216597005630	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
216597005631	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
216597005632	RuvA N terminal domain; Region: RuvA_N; pfam01330
216597005633	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
216597005634	contains a frameshift after residue 80
216597005635	contains two frameshifts after residues 55 and 104
216597005636	hypothetical protein; Provisional; Region: PRK11470
216597005637	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
216597005638	active site
216597005639	putative DNA-binding cleft [nucleotide binding]; other site
216597005640	dimer interface [polypeptide binding]; other site
216597005641	hypothetical protein; Validated; Region: PRK00110
216597005642	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
216597005643	nudix motif; other site
216597005644	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
216597005645	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
216597005646	dimer interface [polypeptide binding]; other site
216597005647	anticodon binding site; other site
216597005648	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
216597005649	homodimer interface [polypeptide binding]; other site
216597005650	motif 1; other site
216597005651	active site
216597005652	motif 2; other site
216597005653	GAD domain; Region: GAD; pfam02938
216597005654	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
216597005655	active site
216597005656	motif 3; other site
216597005657	Isochorismatase family; Region: Isochorismatase; pfam00857
216597005658	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
216597005659	catalytic triad [active]
216597005660	conserved cis-peptide bond; other site
216597005661	hypothetical protein; Provisional; Region: PRK10302
216597005662	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
216597005663	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597005664	S-adenosylmethionine binding site [chemical binding]; other site
216597005665	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597005666	S-adenosylmethionine binding site [chemical binding]; other site
216597005667	copper homeostasis protein CutC; Provisional; Region: PRK11572
216597005668	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
216597005669	putative metal binding site [ion binding]; other site
216597005670	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
216597005671	arginyl-tRNA synthetase; Region: argS; TIGR00456
216597005672	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
216597005673	active site
216597005674	HIGH motif; other site
216597005675	KMSK motif region; other site
216597005676	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
216597005677	tRNA binding surface [nucleotide binding]; other site
216597005678	anticodon binding site; other site
216597005679	penicillin-binding protein 2; Provisional; Region: PRK10795
216597005680	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
216597005681	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
216597005682	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
216597005683	Flagellar protein FlhE; Region: FlhE; pfam06366
216597005684	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
216597005685	FHIPEP family; Region: FHIPEP; pfam00771
216597005686	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
216597005687	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
216597005688	chemotaxis regulator CheZ; Provisional; Region: PRK11166
216597005689	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
216597005690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597005691	active site
216597005692	phosphorylation site [posttranslational modification]
216597005693	intermolecular recognition site; other site
216597005694	dimerization interface [polypeptide binding]; other site
216597005695	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
216597005696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597005697	active site
216597005698	phosphorylation site [posttranslational modification]
216597005699	intermolecular recognition site; other site
216597005700	dimerization interface [polypeptide binding]; other site
216597005701	CheB methylesterase; Region: CheB_methylest; pfam01339
216597005702	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
216597005703	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
216597005704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597005705	S-adenosylmethionine binding site [chemical binding]; other site
216597005706	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
216597005707	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
216597005708	dimer interface [polypeptide binding]; other site
216597005709	ligand binding site [chemical binding]; other site
216597005710	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597005711	dimerization interface [polypeptide binding]; other site
216597005712	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216597005713	dimer interface [polypeptide binding]; other site
216597005714	putative CheW interface [polypeptide binding]; other site
216597005715	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
216597005716	putative CheA interaction surface; other site
216597005717	chemotaxis protein CheA; Provisional; Region: PRK10547
216597005718	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216597005719	putative binding surface; other site
216597005720	active site
216597005721	CheY binding; Region: CheY-binding; pfam09078
216597005722	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
216597005723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597005724	ATP binding site [chemical binding]; other site
216597005725	Mg2+ binding site [ion binding]; other site
216597005726	G-X-G motif; other site
216597005727	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
216597005728	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
216597005729	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
216597005730	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216597005731	ligand binding site [chemical binding]; other site
216597005732	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
216597005733	flagellar motor protein MotA; Validated; Region: PRK09110
216597005734	transcriptional activator FlhC; Provisional; Region: PRK12722
216597005735	transcriptional activator FlhD; Provisional; Region: PRK02909
216597005736	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216597005737	Ligand Binding Site [chemical binding]; other site
216597005738	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
216597005739	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
216597005740	active site
216597005741	homotetramer interface [polypeptide binding]; other site
216597005742	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
216597005743	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
216597005744	DJ-1 family protein; Region: not_thiJ; TIGR01383
216597005745	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
216597005746	conserved cys residue [active]
216597005747	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
216597005748	Ferritin-like domain; Region: Ferritin; pfam00210
216597005749	ferroxidase diiron center [ion binding]; other site
216597005750	hypothetical protein; Provisional; Region: PRK09273
216597005751	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
216597005752	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
216597005753	YecR-like lipoprotein; Region: YecR; pfam13992
216597005754	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
216597005755	Ferritin-like domain; Region: Ferritin; pfam00210
216597005756	ferroxidase diiron center [ion binding]; other site
216597005757	probable metal-binding protein; Region: matur_matur; TIGR03853
216597005758	tyrosine transporter TyrP; Provisional; Region: PRK15132
216597005759	aromatic amino acid transport protein; Region: araaP; TIGR00837
216597005760	hypothetical protein; Provisional; Region: PRK10396
216597005761	yecA family protein; Region: ygfB_yecA; TIGR02292
216597005762	SEC-C motif; Region: SEC-C; pfam02810
216597005763	glucose-6-phosphate 1-dehydrogenase; Region: PLN02640
216597005764	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
216597005765	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
216597005766	NlpC/P60 family; Region: NLPC_P60; cl17555
216597005767	note the frameshift after residue 17
216597005768	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
216597005769	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
216597005770	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
216597005771	GIY-YIG motif/motif A; other site
216597005772	active site
216597005773	catalytic site [active]
216597005774	putative DNA binding site [nucleotide binding]; other site
216597005775	metal binding site [ion binding]; metal-binding site
216597005776	UvrB/uvrC motif; Region: UVR; pfam02151
216597005777	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
216597005778	Helix-hairpin-helix motif; Region: HHH; pfam00633
216597005779	response regulator; Provisional; Region: PRK09483
216597005780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597005781	active site
216597005782	phosphorylation site [posttranslational modification]
216597005783	intermolecular recognition site; other site
216597005784	dimerization interface [polypeptide binding]; other site
216597005785	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597005786	DNA binding residues [nucleotide binding]
216597005787	dimerization interface [polypeptide binding]; other site
216597005788	hypothetical protein; Provisional; Region: PRK10613
216597005789	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
216597005790	Autoinducer binding domain; Region: Autoind_bind; pfam03472
216597005791	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597005792	DNA binding residues [nucleotide binding]
216597005793	dimerization interface [polypeptide binding]; other site
216597005794	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
216597005795	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216597005796	Walker A/P-loop; other site
216597005797	ATP binding site [chemical binding]; other site
216597005798	Q-loop/lid; other site
216597005799	ABC transporter signature motif; other site
216597005800	Walker B; other site
216597005801	D-loop; other site
216597005802	H-loop/switch region; other site
216597005803	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216597005804	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216597005805	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597005806	dimer interface [polypeptide binding]; other site
216597005807	conserved gate region; other site
216597005808	putative PBP binding loops; other site
216597005809	ABC-ATPase subunit interface; other site
216597005810	D-cysteine desulfhydrase; Validated; Region: PRK03910
216597005811	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
216597005812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597005813	catalytic residue [active]
216597005814	cystine transporter subunit; Provisional; Region: PRK11260
216597005815	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597005816	substrate binding pocket [chemical binding]; other site
216597005817	membrane-bound complex binding site; other site
216597005818	hinge residues; other site
216597005819	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
216597005820	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
216597005821	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216597005822	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
216597005823	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216597005824	DNA binding residues [nucleotide binding]
216597005825	Transposase IS200 like; Region: Y1_Tnp; pfam01797
216597005826	flagellin; Validated; Region: PRK08026
216597005827	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
216597005828	Flagellin D3 domain; Region: Flagellin_D3; pfam08884
216597005829	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
216597005830	flagellar capping protein; Reviewed; Region: fliD; PRK08032
216597005831	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
216597005832	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
216597005833	flagellar protein FliS; Validated; Region: fliS; PRK05685
216597005834	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
216597005835	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
216597005836	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
216597005837	active site
216597005838	Na/Ca binding site [ion binding]; other site
216597005839	catalytic site [active]
216597005840	lipoprotein; Provisional; Region: PRK10397
216597005841	putative inner membrane protein; Provisional; Region: PRK11099
216597005842	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
216597005843	CPxP  motif; other site
216597005844	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
216597005845	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
216597005846	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
216597005847	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
216597005848	flagellar motor switch protein FliG; Region: fliG; TIGR00207
216597005849	FliG C-terminal domain; Region: FliG_C; pfam01706
216597005850	flagellar assembly protein H; Validated; Region: fliH; PRK05687
216597005851	Flagellar assembly protein FliH; Region: FliH; pfam02108
216597005852	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
216597005853	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
216597005854	Walker A motif/ATP binding site; other site
216597005855	Walker B motif; other site
216597005856	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
216597005857	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
216597005858	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
216597005859	flagellar hook-length control protein; Provisional; Region: PRK10118
216597005860	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
216597005861	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
216597005862	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
216597005863	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
216597005864	flagellar motor switch protein; Validated; Region: fliN; PRK05698
216597005865	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
216597005866	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
216597005867	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
216597005868	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
216597005869	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
216597005870	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597005871	DNA binding residues [nucleotide binding]
216597005872	dimerization interface [polypeptide binding]; other site
216597005873	hypothetical protein; Provisional; Region: PRK10708
216597005874	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
216597005875	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
216597005876	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597005877	active site
216597005878	motif I; other site
216597005879	motif II; other site
216597005880	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
216597005881	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216597005882	metal binding site [ion binding]; metal-binding site
216597005883	active site
216597005884	I-site; other site
216597005885	Uncharacterized small protein [Function unknown]; Region: COG5475
216597005886	hypothetical protein; Provisional; Region: PRK10062
216597005887	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
216597005888	EamA-like transporter family; Region: EamA; pfam00892
216597005889	EamA-like transporter family; Region: EamA; pfam00892
216597005890	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
216597005891	additional DNA contacts [nucleotide binding]; other site
216597005892	mismatch recognition site; other site
216597005893	active site
216597005894	zinc binding site [ion binding]; other site
216597005895	DNA intercalation site [nucleotide binding]; other site
216597005896	DNA cytosine methylase; Provisional; Region: PRK10458
216597005897	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
216597005898	cofactor binding site; other site
216597005899	DNA binding site [nucleotide binding]
216597005900	substrate interaction site [chemical binding]; other site
216597005901	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
216597005902	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216597005903	Zn2+ binding site [ion binding]; other site
216597005904	Mg2+ binding site [ion binding]; other site
216597005905	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
216597005906	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
216597005907	trimer interface [polypeptide binding]; other site
216597005908	eyelet of channel; other site
216597005909	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
216597005910	DNA-binding site [nucleotide binding]; DNA binding site
216597005911	RNA-binding motif; other site
216597005912	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
216597005913	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
216597005914	active site
216597005915	DNA binding site [nucleotide binding]
216597005916	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
216597005917	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
216597005918	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216597005919	Catalytic site [active]
216597005921	type III secretion system protein; Provisional; Region: PRK15383
216597005922	non-LEE encoded effector protein NleB; Provisional; Region: PRK15382
216597005923	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
216597005924	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
216597005925	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
216597005926	potential frameshift: common BLAST hit: gi|207857369|ref|YP_002244020.1| phage protein
216597005927	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
216597005928	Baseplate J-like protein; Region: Baseplate_J; cl01294
216597005929	Phage protein GP46; Region: GP46; pfam07409
216597005930	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890
216597005931	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
216597005932	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
216597005933	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
216597005934	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
216597005935	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
216597005936	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
216597005937	Phage tail tube protein; Region: Tail_tube; pfam10618
216597005938	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
216597005939	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
216597005940	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
216597005941	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
216597005942	oligomerization interface [polypeptide binding]; other site
216597005943	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
216597005944	Phage capsid family; Region: Phage_capsid; pfam05065
216597005945	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
216597005946	Phage-related protein [Function unknown]; Region: COG4695
216597005947	Phage portal protein; Region: Phage_portal; pfam04860
216597005948	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
216597005949	Phage terminase, small subunit; Region: Terminase_4; pfam05119
216597005950	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
216597005951	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
216597005952	active site
216597005953	KilA-N domain; Region: KilA-N; pfam04383
216597005954	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
216597005955	Predicted chitinase [General function prediction only]; Region: COG3179
216597005956	catalytic residue [active]
216597005957	Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106
216597005958	Protein of unknown function (DUF968); Region: DUF968; pfam06147
216597005959	KilA-N domain; Region: KilA-N; pfam04383
216597005960	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
216597005961	PerC transcriptional activator; Region: PerC; pfam06069
216597005962	Helix-turn-helix domain; Region: HTH_36; pfam13730
216597005963	Ash protein family; Region: Phage_ASH; pfam10554
216597005964	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
216597005965	Predicted transcriptional regulator [Transcription]; Region: COG2932
216597005966	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597005967	non-specific DNA binding site [nucleotide binding]; other site
216597005968	salt bridge; other site
216597005969	sequence-specific DNA binding site [nucleotide binding]; other site
216597005970	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216597005971	Catalytic site [active]
216597005972	Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065
216597005973	HD domain; Region: HD_3; cl17350
216597005974	Protein of unknown function DUF262; Region: DUF262; pfam03235
216597005975	Uncharacterized conserved protein [Function unknown]; Region: COG1479
216597005976	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
216597005977	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
216597005978	active site
216597005979	catalytic site [active]
216597005980	substrate binding site [chemical binding]; other site
216597005981	Domain of unknown function (DUF4224); Region: DUF4224; pfam13986
216597005982	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216597005983	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
216597005984	dimer interface [polypeptide binding]; other site
216597005985	active site
216597005986	Int/Topo IB signature motif; other site
216597005987	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
216597005988	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216597005989	putative protease; Region: PHA00666
216597005990	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
216597005991	Integrase; Region: Integrase_1; pfam12835
216597005992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
216597005993	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
216597005994	Sel1 repeat; Region: Sel1; pfam08238
216597005995	Sel1-like repeats; Region: SEL1; smart00671
216597005996	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
216597005997	AMP nucleosidase; Provisional; Region: PRK08292
216597005998	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
216597005999	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
216597006000	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
216597006001	MATE family multidrug exporter; Provisional; Region: PRK10189
216597006002	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
216597006003	L,D-transpeptidase; Provisional; Region: PRK10190
216597006004	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
216597006005	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
216597006006	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
216597006007	putative dimer interface [polypeptide binding]; other site
216597006008	active site pocket [active]
216597006009	putative cataytic base [active]
216597006010	cobalamin synthase; Reviewed; Region: cobS; PRK00235
216597006011	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
216597006012	homotrimer interface [polypeptide binding]; other site
216597006013	Walker A motif; other site
216597006014	GTP binding site [chemical binding]; other site
216597006015	Walker B motif; other site
216597006016	cobyric acid synthase; Provisional; Region: PRK00784
216597006017	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
216597006018	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
216597006019	catalytic triad [active]
216597006020	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
216597006021	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
216597006022	Walker A/P-loop; other site
216597006023	ATP binding site [chemical binding]; other site
216597006024	Q-loop/lid; other site
216597006025	ABC transporter signature motif; other site
216597006026	Walker B; other site
216597006027	D-loop; other site
216597006028	H-loop/switch region; other site
216597006029	cobalt transport protein CbiQ; Provisional; Region: PRK15485
216597006030	cobalt transport protein CbiN; Provisional; Region: PRK02898
216597006031	cobalt transport protein CbiM; Validated; Region: PRK08319
216597006032	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
216597006033	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
216597006034	active site
216597006035	SAM binding site [chemical binding]; other site
216597006036	homodimer interface [polypeptide binding]; other site
216597006037	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
216597006038	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
216597006039	active site
216597006040	C-terminal domain interface [polypeptide binding]; other site
216597006041	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
216597006042	active site
216597006043	N-terminal domain interface [polypeptide binding]; other site
216597006044	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
216597006045	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
216597006046	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
216597006047	active site
216597006048	SAM binding site [chemical binding]; other site
216597006049	homodimer interface [polypeptide binding]; other site
216597006050	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
216597006051	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
216597006052	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
216597006053	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
216597006054	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
216597006055	active site
216597006056	SAM binding site [chemical binding]; other site
216597006057	homodimer interface [polypeptide binding]; other site
216597006058	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
216597006059	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597006060	S-adenosylmethionine binding site [chemical binding]; other site
216597006061	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
216597006062	active site
216597006063	putative homodimer interface [polypeptide binding]; other site
216597006064	SAM binding site [chemical binding]; other site
216597006065	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
216597006066	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
216597006067	Precorrin-8X methylmutase; Region: CbiC; pfam02570
216597006068	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
216597006069	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
216597006070	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
216597006071	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
216597006072	catalytic triad [active]
216597006073	Sensory domain found in PocR; Region: PocR; pfam10114
216597006074	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
216597006075	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597006076	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216597006077	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597006078	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
216597006079	amphipathic channel; other site
216597006080	Asn-Pro-Ala signature motifs; other site
216597006081	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
216597006082	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
216597006083	Hexamer interface [polypeptide binding]; other site
216597006084	Putative hexagonal pore residue; other site
216597006085	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816
216597006086	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
216597006087	putative hexamer interface [polypeptide binding]; other site
216597006088	putative hexagonal pore; other site
216597006089	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
216597006090	putative hexamer interface [polypeptide binding]; other site
216597006091	putative hexagonal pore; other site
216597006092	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
216597006093	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
216597006094	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
216597006095	alpha-beta subunit interface [polypeptide binding]; other site
216597006096	alpha-gamma subunit interface [polypeptide binding]; other site
216597006097	active site
216597006098	substrate and K+ binding site; other site
216597006099	K+ binding site [ion binding]; other site
216597006100	cobalamin binding site [chemical binding]; other site
216597006101	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
216597006102	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
216597006103	Cell division protein FtsA; Region: FtsA; cl17206
216597006104	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
216597006105	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
216597006106	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
216597006107	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
216597006108	Hexamer interface [polypeptide binding]; other site
216597006109	Putative hexagonal pore residue; other site
216597006110	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
216597006111	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
216597006112	putative hexamer interface [polypeptide binding]; other site
216597006113	putative hexagonal pore; other site
216597006114	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
216597006115	Propanediol utilisation protein PduL; Region: PduL; pfam06130
216597006116	Propanediol utilisation protein PduL; Region: PduL; pfam06130
216597006117	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
216597006118	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
216597006119	Hexamer/Pentamer interface [polypeptide binding]; other site
216597006120	central pore; other site
216597006121	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
216597006122	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
216597006123	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
216597006124	putative catalytic cysteine [active]
216597006125	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
216597006126	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
216597006127	putative active site [active]
216597006128	metal binding site [ion binding]; metal-binding site
216597006129	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
216597006130	SLBB domain; Region: SLBB; pfam10531
216597006131	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
216597006132	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
216597006133	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
216597006134	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
216597006135	putative hexamer interface [polypeptide binding]; other site
216597006136	putative hexagonal pore; other site
216597006137	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
216597006138	putative hexamer interface [polypeptide binding]; other site
216597006139	putative hexagonal pore; other site
216597006140	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
216597006141	putative hexamer interface [polypeptide binding]; other site
216597006142	putative hexagonal pore; other site
216597006143	Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662
216597006144	G3 box; other site
216597006145	Switch II region; other site
216597006146	GTP/Mg2+ binding site [chemical binding]; other site
216597006147	G4 box; other site
216597006148	G5 box; other site
216597006149	propionate kinase; Reviewed; Region: PRK12397
216597006150	propionate/acetate kinase; Provisional; Region: PRK12379
216597006151	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
216597006152	hypothetical protein; Provisional; Region: PRK05423
216597006153	Predicted membrane protein [Function unknown]; Region: COG1289
216597006154	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
216597006155	DNA gyrase inhibitor; Provisional; Region: PRK10016
216597006156	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
216597006157	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
216597006158	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
216597006159	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
216597006160	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
216597006161	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
216597006162	4Fe-4S binding domain; Region: Fer4; cl02805
216597006163	thiosulfate reductase PhsA; Provisional; Region: PRK15488
216597006164	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
216597006165	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
216597006166	putative [Fe4-S4] binding site [ion binding]; other site
216597006167	putative molybdopterin cofactor binding site [chemical binding]; other site
216597006168	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
216597006169	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
216597006170	putative molybdopterin cofactor binding site; other site
216597006172	E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377
216597006173	SopA-like central domain; Region: SopA; pfam13981
216597006174	SopA-like catalytic domain; Region: SopA_C; pfam13979
216597006175	exonuclease I; Provisional; Region: sbcB; PRK11779
216597006176	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
216597006177	active site
216597006178	catalytic site [active]
216597006179	substrate binding site [chemical binding]; other site
216597006180	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
216597006181	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
216597006182	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597006183	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
216597006184	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216597006185	dimerization interface [polypeptide binding]; other site
216597006186	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216597006187	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
216597006188	putative NAD(P) binding site [chemical binding]; other site
216597006189	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
216597006190	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
216597006191	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
216597006192	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
216597006193	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
216597006194	NAD binding site [chemical binding]; other site
216597006195	dimerization interface [polypeptide binding]; other site
216597006196	product binding site; other site
216597006197	substrate binding site [chemical binding]; other site
216597006198	zinc binding site [ion binding]; other site
216597006199	catalytic residues [active]
216597006200	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
216597006201	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216597006202	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597006203	homodimer interface [polypeptide binding]; other site
216597006204	catalytic residue [active]
216597006205	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
216597006206	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597006207	active site
216597006208	motif I; other site
216597006209	motif II; other site
216597006210	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
216597006211	putative active site pocket [active]
216597006212	4-fold oligomerization interface [polypeptide binding]; other site
216597006213	metal binding residues [ion binding]; metal-binding site
216597006214	3-fold/trimer interface [polypeptide binding]; other site
216597006215	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
216597006216	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
216597006217	putative active site [active]
216597006218	oxyanion strand; other site
216597006219	catalytic triad [active]
216597006220	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
216597006221	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
216597006222	catalytic residues [active]
216597006223	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
216597006224	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
216597006225	substrate binding site [chemical binding]; other site
216597006226	glutamase interaction surface [polypeptide binding]; other site
216597006227	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
216597006228	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
216597006229	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
216597006230	metal binding site [ion binding]; metal-binding site
216597006231	chain length determinant protein WzzB; Provisional; Region: PRK15471
216597006232	Chain length determinant protein; Region: Wzz; pfam02706
216597006233	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
216597006234	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
216597006235	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
216597006236	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
216597006237	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
216597006238	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
216597006239	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
216597006240	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
216597006241	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
216597006242	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
216597006243	Bacterial sugar transferase; Region: Bac_transf; pfam02397
216597006244	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
216597006245	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
216597006246	active site
216597006247	substrate binding site [chemical binding]; other site
216597006248	metal binding site [ion binding]; metal-binding site
216597006249	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
216597006250	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
216597006251	Substrate binding site; other site
216597006252	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
216597006253	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
216597006254	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
216597006255	active site
216597006256	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216597006257	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216597006258	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
216597006259	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
216597006260	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
216597006261	active site
216597006262	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
216597006263	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
216597006264	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216597006265	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
216597006266	NAD(P) binding site [chemical binding]; other site
216597006267	active site
216597006268	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
216597006269	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
216597006270	inhibitor-cofactor binding pocket; inhibition site
216597006271	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597006272	catalytic residue [active]
216597006273	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
216597006274	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
216597006275	NAD binding site [chemical binding]; other site
216597006276	homotetramer interface [polypeptide binding]; other site
216597006277	homodimer interface [polypeptide binding]; other site
216597006278	substrate binding site [chemical binding]; other site
216597006279	active site
216597006280	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
216597006281	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
216597006282	substrate binding site; other site
216597006283	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
216597006284	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216597006285	catalytic loop [active]
216597006286	iron binding site [ion binding]; other site
216597006287	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
216597006288	FAD binding pocket [chemical binding]; other site
216597006289	FAD binding motif [chemical binding]; other site
216597006290	phosphate binding motif [ion binding]; other site
216597006291	beta-alpha-beta structure motif; other site
216597006292	NAD binding pocket [chemical binding]; other site
216597006293	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
216597006294	glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480
216597006295	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
216597006296	substrate binding site; other site
216597006297	tetramer interface; other site
216597006298	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
216597006299	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
216597006300	NADP binding site [chemical binding]; other site
216597006301	active site
216597006302	putative substrate binding site [chemical binding]; other site
216597006303	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
216597006304	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
216597006305	NAD binding site [chemical binding]; other site
216597006306	substrate binding site [chemical binding]; other site
216597006307	homodimer interface [polypeptide binding]; other site
216597006308	active site
216597006309	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
216597006310	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
216597006311	active site
216597006312	tetramer interface; other site
216597006313	colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004
216597006314	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
216597006315	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
216597006316	putative ADP-binding pocket [chemical binding]; other site
216597006317	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
216597006318	colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006
216597006319	colanic acid exporter; Provisional; Region: PRK10459
216597006320	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
216597006321	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
216597006322	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
216597006323	phosphomannomutase CpsG; Provisional; Region: PRK15414
216597006324	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
216597006325	active site
216597006326	substrate binding site [chemical binding]; other site
216597006327	metal binding site [ion binding]; metal-binding site
216597006328	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
216597006329	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
216597006330	Substrate binding site; other site
216597006331	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
216597006332	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
216597006333	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
216597006334	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
216597006335	active site
216597006336	GDP-Mannose binding site [chemical binding]; other site
216597006337	dimer interface [polypeptide binding]; other site
216597006338	modified nudix motif
216597006339	metal binding site [ion binding]; metal-binding site
216597006340	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
216597006341	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
216597006342	NADP binding site [chemical binding]; other site
216597006343	active site
216597006344	putative substrate binding site [chemical binding]; other site
216597006345	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
216597006346	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
216597006347	NADP-binding site; other site
216597006348	homotetramer interface [polypeptide binding]; other site
216597006349	substrate binding site [chemical binding]; other site
216597006350	homodimer interface [polypeptide binding]; other site
216597006351	active site
216597006352	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
216597006353	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
216597006354	putative trimer interface [polypeptide binding]; other site
216597006355	putative active site [active]
216597006356	putative substrate binding site [chemical binding]; other site
216597006357	putative CoA binding site [chemical binding]; other site
216597006358	putative glycosyl transferase; Provisional; Region: PRK10063
216597006359	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
216597006360	metal-binding site
216597006361	putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075
216597006362	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
216597006363	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
216597006364	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
216597006365	putative acyl transferase; Provisional; Region: PRK10191
216597006366	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
216597006367	trimer interface [polypeptide binding]; other site
216597006368	active site
216597006369	substrate binding site [chemical binding]; other site
216597006370	CoA binding site [chemical binding]; other site
216597006371	putative glycosyl transferase; Provisional; Region: PRK10018
216597006372	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
216597006373	active site
216597006374	tyrosine kinase; Provisional; Region: PRK11519
216597006375	Chain length determinant protein; Region: Wzz; pfam02706
216597006376	Chain length determinant protein; Region: Wzz; cl15801
216597006377	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
216597006378	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216597006379	Low molecular weight phosphatase family; Region: LMWPc; cd00115
216597006380	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
216597006381	active site
216597006382	polysaccharide export protein Wza; Provisional; Region: PRK15078
216597006383	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
216597006384	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
216597006385	FOG: CBS domain [General function prediction only]; Region: COG0517
216597006386	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
216597006387	Transporter associated domain; Region: CorC_HlyC; smart01091
216597006388	putative assembly protein; Provisional; Region: PRK10833
216597006389	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
216597006390	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
216597006391	trimer interface [polypeptide binding]; other site
216597006392	active site
216597006393	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
216597006394	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
216597006395	ATP-binding site [chemical binding]; other site
216597006396	Sugar specificity; other site
216597006397	Pyrimidine base specificity; other site
216597006398	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
216597006399	PAS domain S-box; Region: sensory_box; TIGR00229
216597006400	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216597006401	putative active site [active]
216597006402	heme pocket [chemical binding]; other site
216597006403	PAS domain S-box; Region: sensory_box; TIGR00229
216597006404	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216597006405	putative active site [active]
216597006406	heme pocket [chemical binding]; other site
216597006407	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216597006408	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216597006409	metal binding site [ion binding]; metal-binding site
216597006410	active site
216597006411	I-site; other site
216597006412	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597006413	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
216597006414	AlkA N-terminal domain; Region: AlkA_N; pfam06029
216597006415	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
216597006416	minor groove reading motif; other site
216597006417	helix-hairpin-helix signature motif; other site
216597006418	substrate binding pocket [chemical binding]; other site
216597006419	active site
216597006420	putative chaperone; Provisional; Region: PRK11678
216597006421	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
216597006422	nucleotide binding site [chemical binding]; other site
216597006423	putative NEF/HSP70 interaction site [polypeptide binding]; other site
216597006424	SBD interface [polypeptide binding]; other site
216597006425	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
216597006426	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216597006427	HlyD family secretion protein; Region: HlyD_3; pfam13437
216597006428	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
216597006429	Protein export membrane protein; Region: SecD_SecF; cl14618
216597006430	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
216597006431	putative transporter; Provisional; Region: PRK10504
216597006432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597006433	putative substrate translocation pore; other site
216597006434	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
216597006435	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597006436	dimerization interface [polypeptide binding]; other site
216597006437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597006438	dimer interface [polypeptide binding]; other site
216597006439	phosphorylation site [posttranslational modification]
216597006440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597006441	ATP binding site [chemical binding]; other site
216597006442	Mg2+ binding site [ion binding]; other site
216597006443	G-X-G motif; other site
216597006444	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
216597006445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597006446	active site
216597006447	phosphorylation site [posttranslational modification]
216597006448	intermolecular recognition site; other site
216597006449	dimerization interface [polypeptide binding]; other site
216597006450	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597006451	DNA binding site [nucleotide binding]
216597006452	PcfJ-like protein; Region: PcfJ; pfam14284
216597006453	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
216597006454	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
216597006455	putative protease; Provisional; Region: PRK15452
216597006456	Peptidase family U32; Region: Peptidase_U32; pfam01136
216597006457	type III secretion system protein; Provisional; Region: PRK15383
216597006458	non-LEE encoded effector protein NleB; Provisional; Region: PRK15382
216597006459	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
216597006460	lipid kinase; Reviewed; Region: PRK13054
216597006461	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
216597006462	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
216597006463	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
216597006464	putative active site; other site
216597006465	catalytic residue [active]
216597006466	nucleoside transporter; Region: 2A0110; TIGR00889
216597006467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597006468	putative substrate translocation pore; other site
216597006469	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
216597006470	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216597006471	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
216597006472	substrate binding site [chemical binding]; other site
216597006473	ATP binding site [chemical binding]; other site
216597006474	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
216597006475	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597006476	DNA-binding site [nucleotide binding]; DNA binding site
216597006477	UTRA domain; Region: UTRA; pfam07702
216597006478	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
216597006479	dimer interface [polypeptide binding]; other site
216597006480	substrate binding site [chemical binding]; other site
216597006481	ATP binding site [chemical binding]; other site
216597006482	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
216597006483	substrate binding site [chemical binding]; other site
216597006484	multimerization interface [polypeptide binding]; other site
216597006485	ATP binding site [chemical binding]; other site
216597006486	Predicted integral membrane protein [Function unknown]; Region: COG5455
216597006487	putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216
216597006488	putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252
216597006489	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
216597006490	PapC N-terminal domain; Region: PapC_N; pfam13954
216597006491	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216597006492	PapC C-terminal domain; Region: PapC_C; pfam13953
216597006493	fimbrial chaperone protein PegB; Provisional; Region: PRK15218
216597006494	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597006495	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597006496	fimbrial chaperone protein; Provisional; Region: PRK15220
216597006497	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
216597006498	antiporter inner membrane protein; Provisional; Region: PRK11670
216597006499	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
216597006500	Walker A motif; other site
216597006501	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
216597006502	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
216597006503	active site
216597006504	HIGH motif; other site
216597006505	KMSKS motif; other site
216597006506	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
216597006507	tRNA binding surface [nucleotide binding]; other site
216597006508	anticodon binding site; other site
216597006509	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
216597006510	dimer interface [polypeptide binding]; other site
216597006511	putative tRNA-binding site [nucleotide binding]; other site
216597006512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
216597006513	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
216597006514	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
216597006515	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
216597006516	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
216597006517	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
216597006518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597006519	active site
216597006520	phosphorylation site [posttranslational modification]
216597006521	intermolecular recognition site; other site
216597006522	dimerization interface [polypeptide binding]; other site
216597006523	LytTr DNA-binding domain; Region: LytTR; pfam04397
216597006524	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
216597006525	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
216597006526	GAF domain; Region: GAF; pfam01590
216597006527	Histidine kinase; Region: His_kinase; pfam06580
216597006528	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597006529	ATP binding site [chemical binding]; other site
216597006530	Mg2+ binding site [ion binding]; other site
216597006531	G-X-G motif; other site
216597006532	transcriptional regulator MirA; Provisional; Region: PRK15043
216597006533	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
216597006534	DNA binding residues [nucleotide binding]
216597006535	hypothetical protein; Provisional; Region: PRK13681
216597006536	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
216597006537	putative PBP binding loops; other site
216597006538	ABC-ATPase subunit interface; other site
216597006539	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
216597006540	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
216597006541	Walker A/P-loop; other site
216597006542	ATP binding site [chemical binding]; other site
216597006543	Q-loop/lid; other site
216597006544	ABC transporter signature motif; other site
216597006545	Walker B; other site
216597006546	D-loop; other site
216597006547	H-loop/switch region; other site
216597006548	CBS domain; Region: CBS; pfam00571
216597006549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597006550	dimer interface [polypeptide binding]; other site
216597006551	conserved gate region; other site
216597006552	ABC-ATPase subunit interface; other site
216597006553	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
216597006554	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
216597006555	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
216597006556	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
216597006557	D-lactate dehydrogenase; Provisional; Region: PRK11183
216597006558	FAD binding domain; Region: FAD_binding_4; pfam01565
216597006559	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
216597006560	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
216597006561	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
216597006562	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
216597006563	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
216597006564	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
216597006565	oxidoreductase; Provisional; Region: PRK12743
216597006566	classical (c) SDRs; Region: SDR_c; cd05233
216597006567	NAD(P) binding site [chemical binding]; other site
216597006568	active site
216597006569	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
216597006570	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
216597006571	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
216597006572	FMN binding site [chemical binding]; other site
216597006573	active site
216597006574	catalytic residues [active]
216597006575	substrate binding site [chemical binding]; other site
216597006576	salicylate hydroxylase; Provisional; Region: PRK08163
216597006577	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
216597006578	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
216597006579	maleylacetoacetate isomerase; Region: maiA; TIGR01262
216597006580	C-terminal domain interface [polypeptide binding]; other site
216597006581	GSH binding site (G-site) [chemical binding]; other site
216597006582	putative dimer interface [polypeptide binding]; other site
216597006583	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
216597006584	dimer interface [polypeptide binding]; other site
216597006585	N-terminal domain interface [polypeptide binding]; other site
216597006586	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
216597006587	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
216597006588	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
216597006589	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
216597006590	Cupin domain; Region: Cupin_2; pfam07883
216597006591	Cupin domain; Region: Cupin_2; pfam07883
216597006592	benzoate transport; Region: 2A0115; TIGR00895
216597006593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597006594	putative substrate translocation pore; other site
216597006595	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
216597006596	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597006597	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216597006598	dimerization interface [polypeptide binding]; other site
216597006599	hypothetical protein; Provisional; Region: PRK01821
216597006600	hypothetical protein; Provisional; Region: PRK10711
216597006601	cytidine deaminase; Provisional; Region: PRK09027
216597006602	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
216597006603	active site
216597006604	catalytic motif [active]
216597006605	Zn binding site [ion binding]; other site
216597006606	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
216597006607	active site
216597006608	catalytic motif [active]
216597006609	Zn binding site [ion binding]; other site
216597006610	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
216597006611	putative active site [active]
216597006612	Protein of unknown function (DUF2542); Region: DUF2542; pfam10808
216597006613	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
216597006614	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216597006615	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216597006616	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
216597006617	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
216597006618	homodimer interface [polypeptide binding]; other site
216597006619	active site
216597006620	FMN binding site [chemical binding]; other site
216597006621	substrate binding site [chemical binding]; other site
216597006622	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216597006623	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216597006624	TM-ABC transporter signature motif; other site
216597006625	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
216597006626	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
216597006627	Walker A/P-loop; other site
216597006628	ATP binding site [chemical binding]; other site
216597006629	Q-loop/lid; other site
216597006630	ABC transporter signature motif; other site
216597006631	Walker B; other site
216597006632	D-loop; other site
216597006633	H-loop/switch region; other site
216597006634	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
216597006635	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
216597006636	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
216597006637	ligand binding site [chemical binding]; other site
216597006638	calcium binding site [ion binding]; other site
216597006639	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
216597006640	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597006641	DNA binding site [nucleotide binding]
216597006642	domain linker motif; other site
216597006643	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
216597006644	dimerization interface (closed form) [polypeptide binding]; other site
216597006645	ligand binding site [chemical binding]; other site
216597006646	Predicted membrane protein [Function unknown]; Region: COG2311
216597006647	hypothetical protein; Provisional; Region: PRK10835
216597006648	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
216597006649	GTP cyclohydrolase I; Provisional; Region: PLN03044
216597006650	active site
216597006651	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
216597006652	S-formylglutathione hydrolase; Region: PLN02442
216597006653	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597006654	non-specific DNA binding site [nucleotide binding]; other site
216597006655	salt bridge; other site
216597006656	sequence-specific DNA binding site [nucleotide binding]; other site
216597006657	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
216597006658	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
216597006659	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
216597006660	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
216597006661	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
216597006662	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597006663	motif II; other site
216597006664	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
216597006665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597006666	putative substrate translocation pore; other site
216597006667	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
216597006668	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216597006669	N-terminal plug; other site
216597006670	ligand-binding site [chemical binding]; other site
216597006671	lysine transporter; Provisional; Region: PRK10836
216597006672	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
216597006673	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597006674	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
216597006675	putative dimerization interface [polypeptide binding]; other site
216597006676	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
216597006677	endonuclease IV; Provisional; Region: PRK01060
216597006678	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
216597006679	AP (apurinic/apyrimidinic) site pocket; other site
216597006680	DNA interaction; other site
216597006681	Metal-binding active site; metal-binding site
216597006682	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
216597006683	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
216597006684	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
216597006685	active site
216597006686	P-loop; other site
216597006687	phosphorylation site [posttranslational modification]
216597006688	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
216597006689	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
216597006690	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
216597006691	putative substrate binding site [chemical binding]; other site
216597006692	putative ATP binding site [chemical binding]; other site
216597006693	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
216597006694	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216597006695	active site
216597006696	phosphorylation site [posttranslational modification]
216597006697	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
216597006698	dimerization domain swap beta strand [polypeptide binding]; other site
216597006699	regulatory protein interface [polypeptide binding]; other site
216597006700	active site
216597006701	regulatory phosphorylation site [posttranslational modification]; other site
216597006702	sugar efflux transporter B; Provisional; Region: PRK15011
216597006703	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597006704	putative substrate translocation pore; other site
216597006705	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
216597006706	Flagellin N-methylase; Region: FliB; cl00497
216597006707	elongation factor P; Provisional; Region: PRK04542
216597006708	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
216597006709	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
216597006710	RNA binding site [nucleotide binding]; other site
216597006711	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
216597006712	RNA binding site [nucleotide binding]; other site
216597006713	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
216597006714	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
216597006715	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
216597006716	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
216597006717	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
216597006718	active site
216597006719	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
216597006720	NlpC/P60 family; Region: NLPC_P60; pfam00877
216597006721	phage resistance protein; Provisional; Region: PRK10551
216597006722	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
216597006723	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597006724	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
216597006725	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
216597006726	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
216597006727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597006728	dimer interface [polypeptide binding]; other site
216597006729	conserved gate region; other site
216597006730	putative PBP binding loops; other site
216597006731	ABC-ATPase subunit interface; other site
216597006732	microcin C ABC transporter permease; Provisional; Region: PRK15021
216597006733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597006734	dimer interface [polypeptide binding]; other site
216597006735	conserved gate region; other site
216597006736	ABC-ATPase subunit interface; other site
216597006737	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
216597006738	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216597006739	Walker A/P-loop; other site
216597006740	ATP binding site [chemical binding]; other site
216597006741	Q-loop/lid; other site
216597006742	ABC transporter signature motif; other site
216597006743	Walker B; other site
216597006744	D-loop; other site
216597006745	H-loop/switch region; other site
216597006746	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
216597006747	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216597006748	Walker A/P-loop; other site
216597006749	ATP binding site [chemical binding]; other site
216597006750	Q-loop/lid; other site
216597006751	ABC transporter signature motif; other site
216597006752	Walker B; other site
216597006753	D-loop; other site
216597006754	H-loop/switch region; other site
216597006755	hypothetical protein; Provisional; Region: PRK11835
216597006756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597006757	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
216597006758	putative substrate translocation pore; other site
216597006759	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
216597006760	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216597006761	RNA binding surface [nucleotide binding]; other site
216597006762	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
216597006763	active site
216597006764	uracil binding [chemical binding]; other site
216597006765	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
216597006766	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216597006767	ATP binding site [chemical binding]; other site
216597006768	putative Mg++ binding site [ion binding]; other site
216597006769	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597006770	nucleotide binding region [chemical binding]; other site
216597006771	ATP-binding site [chemical binding]; other site
216597006772	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
216597006773	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
216597006774	5S rRNA interface [nucleotide binding]; other site
216597006775	CTC domain interface [polypeptide binding]; other site
216597006776	L16 interface [polypeptide binding]; other site
216597006777	Nucleoid-associated protein [General function prediction only]; Region: COG3081
216597006778	nucleoid-associated protein NdpA; Validated; Region: PRK00378
216597006779	hypothetical protein; Provisional; Region: PRK13689
216597006780	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
216597006781	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
216597006782	Sulfatase; Region: Sulfatase; cl17466
216597006783	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
216597006784	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216597006785	Catalytic site [active]
216597006786	DinI-like family; Region: DinI; cl11630
216597006787	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
216597006788	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
216597006789	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
216597006790	Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903
216597006791	Phage head maturation protease [General function prediction only]; Region: COG3740
216597006792	Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938
216597006793	Phage-related protein [Function unknown]; Region: COG4695; cl01923
216597006794	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
216597006795	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
216597006796	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
216597006797	Protein of unknown function (DUF968); Region: DUF968; pfam06147
216597006798	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
216597006799	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
216597006800	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
216597006801	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
216597006802	Leucine-rich repeats; other site
216597006803	Substrate binding site [chemical binding]; other site
216597006805	DinI-like family; Region: DinI; cl11630
216597006806	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
216597006807	transcriptional regulator NarP; Provisional; Region: PRK10403
216597006808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597006809	active site
216597006810	phosphorylation site [posttranslational modification]
216597006811	intermolecular recognition site; other site
216597006812	dimerization interface [polypeptide binding]; other site
216597006813	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597006814	DNA binding residues [nucleotide binding]
216597006815	dimerization interface [polypeptide binding]; other site
216597006816	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
216597006817	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
216597006818	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
216597006819	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
216597006820	catalytic residues [active]
216597006821	central insert; other site
216597006822	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
216597006823	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
216597006824	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
216597006825	heme exporter protein CcmC; Region: ccmC; TIGR01191
216597006826	heme exporter protein CcmB; Region: ccmB; TIGR01190
216597006827	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
216597006828	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597006829	Walker A/P-loop; other site
216597006830	ATP binding site [chemical binding]; other site
216597006831	Q-loop/lid; other site
216597006832	ABC transporter signature motif; other site
216597006833	Walker B; other site
216597006834	D-loop; other site
216597006835	H-loop/switch region; other site
216597006836	cytochrome c-type protein NapC; Provisional; Region: PRK10617
216597006837	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
216597006838	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
216597006839	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
216597006840	4Fe-4S binding domain; Region: Fer4_5; pfam12801
216597006841	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
216597006842	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
216597006843	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
216597006844	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
216597006845	[4Fe-4S] binding site [ion binding]; other site
216597006846	molybdopterin cofactor binding site; other site
216597006847	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
216597006848	molybdopterin cofactor binding site; other site
216597006849	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
216597006850	ferredoxin-type protein; Provisional; Region: PRK10194
216597006851	4Fe-4S binding domain; Region: Fer4; cl02805
216597006852	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
216597006853	secondary substrate binding site; other site
216597006854	primary substrate binding site; other site
216597006855	inhibition loop; other site
216597006856	dimerization interface [polypeptide binding]; other site
216597006857	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
216597006858	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
216597006859	Walker A/P-loop; other site
216597006860	ATP binding site [chemical binding]; other site
216597006861	Q-loop/lid; other site
216597006862	ABC transporter signature motif; other site
216597006863	Walker B; other site
216597006864	D-loop; other site
216597006865	H-loop/switch region; other site
216597006866	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
216597006867	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
216597006868	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
216597006869	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597006870	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
216597006871	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
216597006872	DNA binding site [nucleotide binding]
216597006873	active site
216597006874	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
216597006875	ApbE family; Region: ApbE; pfam02424
216597006876	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
216597006877	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
216597006878	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
216597006879	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597006880	ATP binding site [chemical binding]; other site
216597006881	G-X-G motif; other site
216597006882	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216597006883	putative binding surface; other site
216597006884	active site
216597006885	transcriptional regulator RcsB; Provisional; Region: PRK10840
216597006886	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597006887	active site
216597006888	phosphorylation site [posttranslational modification]
216597006889	intermolecular recognition site; other site
216597006890	dimerization interface [polypeptide binding]; other site
216597006891	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597006892	DNA binding residues [nucleotide binding]
216597006893	dimerization interface [polypeptide binding]; other site
216597006894	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
216597006895	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597006896	dimer interface [polypeptide binding]; other site
216597006897	phosphorylation site [posttranslational modification]
216597006898	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597006899	ATP binding site [chemical binding]; other site
216597006900	Mg2+ binding site [ion binding]; other site
216597006901	G-X-G motif; other site
216597006902	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
216597006903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597006904	active site
216597006905	phosphorylation site [posttranslational modification]
216597006906	intermolecular recognition site; other site
216597006907	dimerization interface [polypeptide binding]; other site
216597006908	DNA gyrase subunit A; Validated; Region: PRK05560
216597006909	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
216597006910	CAP-like domain; other site
216597006911	active site
216597006912	primary dimer interface [polypeptide binding]; other site
216597006913	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216597006914	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216597006915	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216597006916	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216597006917	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216597006918	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216597006919	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
216597006920	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
216597006921	active site pocket [active]
216597006922	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
216597006923	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597006924	putative substrate translocation pore; other site
216597006925	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216597006926	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597006927	DNA-binding site [nucleotide binding]; DNA binding site
216597006928	FCD domain; Region: FCD; pfam07729
216597006929	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
216597006930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597006931	S-adenosylmethionine binding site [chemical binding]; other site
216597006932	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
216597006933	ATP cone domain; Region: ATP-cone; pfam03477
216597006934	Class I ribonucleotide reductase; Region: RNR_I; cd01679
216597006935	active site
216597006936	dimer interface [polypeptide binding]; other site
216597006937	catalytic residues [active]
216597006938	effector binding site; other site
216597006939	R2 peptide binding site; other site
216597006940	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
216597006941	dimer interface [polypeptide binding]; other site
216597006942	putative radical transfer pathway; other site
216597006943	diiron center [ion binding]; other site
216597006944	tyrosyl radical; other site
216597006945	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
216597006946	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216597006947	catalytic loop [active]
216597006948	iron binding site [ion binding]; other site
216597006949	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216597006950	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597006951	putative substrate translocation pore; other site
216597006952	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
216597006953	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597006954	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216597006955	dimerization interface [polypeptide binding]; other site
216597006956	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
216597006957	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
216597006958	active site
216597006959	catalytic site [active]
216597006960	metal binding site [ion binding]; metal-binding site
216597006961	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
216597006962	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597006963	putative substrate translocation pore; other site
216597006964	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
216597006965	hydroxyglutarate oxidase; Provisional; Region: PRK11728
216597006966	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
216597006967	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
216597006968	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
216597006969	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
216597006970	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
216597006971	Cysteine-rich domain; Region: CCG; pfam02754
216597006972	Cysteine-rich domain; Region: CCG; pfam02754
216597006973	deubiquitinase SseL; Provisional; Region: PRK14848
216597006974	hypothetical protein; Provisional; Region: PRK03673
216597006975	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
216597006976	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597006977	D-galactonate transporter; Region: 2A0114; TIGR00893
216597006978	putative substrate translocation pore; other site
216597006979	L-rhamnonate dehydratase; Provisional; Region: PRK15440
216597006980	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
216597006981	putative active site pocket [active]
216597006982	putative metal binding site [ion binding]; other site
216597006983	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
216597006984	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216597006985	Bacterial transcriptional regulator; Region: IclR; pfam01614
216597006986	hypothetical protein; Provisional; Region: PRK03673
216597006987	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
216597006988	putative MPT binding site; other site
216597006989	Competence-damaged protein; Region: CinA; cl00666
216597006990	YfaZ precursor; Region: YfaZ; pfam07437
216597006991	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
216597006992	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
216597006993	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
216597006994	catalytic core [active]
216597006995	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
216597006996	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
216597006997	inhibitor-cofactor binding pocket; inhibition site
216597006998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597006999	catalytic residue [active]
216597007000	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
216597007001	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
216597007002	Ligand binding site; other site
216597007003	Putative Catalytic site; other site
216597007004	DXD motif; other site
216597007005	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
216597007006	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
216597007007	active site
216597007008	substrate binding site [chemical binding]; other site
216597007009	cosubstrate binding site; other site
216597007010	catalytic site [active]
216597007011	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
216597007012	active site
216597007013	hexamer interface [polypeptide binding]; other site
216597007014	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
216597007015	NAD binding site [chemical binding]; other site
216597007016	substrate binding site [chemical binding]; other site
216597007017	active site
216597007018	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
216597007019	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
216597007020	putative active site [active]
216597007021	putative catalytic site [active]
216597007022	putative Zn binding site [ion binding]; other site
216597007023	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
216597007024	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
216597007025	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
216597007026	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
216597007027	signal transduction protein PmrD; Provisional; Region: PRK15450
216597007028	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
216597007029	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
216597007030	acyl-activating enzyme (AAE) consensus motif; other site
216597007031	putative AMP binding site [chemical binding]; other site
216597007032	putative active site [active]
216597007033	putative CoA binding site [chemical binding]; other site
216597007034	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
216597007035	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
216597007036	active site
216597007037	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216597007038	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
216597007039	substrate binding site [chemical binding]; other site
216597007040	oxyanion hole (OAH) forming residues; other site
216597007041	trimer interface [polypeptide binding]; other site
216597007042	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
216597007043	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
216597007044	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
216597007045	dimer interface [polypeptide binding]; other site
216597007046	tetramer interface [polypeptide binding]; other site
216597007047	PYR/PP interface [polypeptide binding]; other site
216597007048	TPP binding site [chemical binding]; other site
216597007049	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
216597007050	TPP-binding site; other site
216597007051	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
216597007052	isochorismate synthases; Region: isochor_syn; TIGR00543
216597007053	hypothetical protein; Provisional; Region: PRK10404
216597007054	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597007055	Coenzyme A binding pocket [chemical binding]; other site
216597007056	ribonuclease BN; Region: true_RNase_BN; TIGR02649
216597007057	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
216597007058	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
216597007059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597007060	active site
216597007061	phosphorylation site [posttranslational modification]
216597007062	intermolecular recognition site; other site
216597007063	dimerization interface [polypeptide binding]; other site
216597007064	von Willebrand factor; Region: vWF_A; pfam12450
216597007065	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
216597007066	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
216597007067	metal ion-dependent adhesion site (MIDAS); other site
216597007068	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
216597007069	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
216597007070	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216597007071	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
216597007072	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216597007073	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
216597007074	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
216597007075	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216597007076	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
216597007077	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
216597007078	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
216597007079	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
216597007080	4Fe-4S binding domain; Region: Fer4; pfam00037
216597007081	4Fe-4S binding domain; Region: Fer4; pfam00037
216597007082	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
216597007083	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
216597007084	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216597007085	catalytic loop [active]
216597007086	iron binding site [ion binding]; other site
216597007087	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
216597007088	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
216597007089	[4Fe-4S] binding site [ion binding]; other site
216597007090	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
216597007091	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
216597007092	SLBB domain; Region: SLBB; pfam10531
216597007093	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
216597007094	NADH dehydrogenase subunit E; Validated; Region: PRK07539
216597007095	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
216597007096	putative dimer interface [polypeptide binding]; other site
216597007097	[2Fe-2S] cluster binding site [ion binding]; other site
216597007098	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
216597007099	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
216597007100	NADH dehydrogenase subunit D; Validated; Region: PRK06075
216597007101	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
216597007102	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
216597007103	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
216597007104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597007105	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
216597007106	putative dimerization interface [polypeptide binding]; other site
216597007107	aminotransferase AlaT; Validated; Region: PRK09265
216597007108	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216597007109	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597007110	homodimer interface [polypeptide binding]; other site
216597007111	catalytic residue [active]
216597007112	5'-nucleotidase; Provisional; Region: PRK03826
216597007113	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
216597007114	transmembrane helices; other site
216597007115	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
216597007116	TrkA-C domain; Region: TrkA_C; pfam02080
216597007117	TrkA-C domain; Region: TrkA_C; pfam02080
216597007118	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
216597007119	putative phosphatase; Provisional; Region: PRK11587
216597007120	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597007121	motif II; other site
216597007122	hypothetical protein; Validated; Region: PRK05445
216597007123	hypothetical protein; Provisional; Region: PRK01816
216597007124	propionate/acetate kinase; Provisional; Region: PRK12379
216597007125	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
216597007126	phosphate acetyltransferase; Reviewed; Region: PRK05632
216597007127	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216597007128	DRTGG domain; Region: DRTGG; pfam07085
216597007129	phosphate acetyltransferase; Region: pta; TIGR00651
216597007130	hypothetical protein; Provisional; Region: PRK11588
216597007131	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
216597007132	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
216597007133	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
216597007134	PYR/PP interface [polypeptide binding]; other site
216597007135	dimer interface [polypeptide binding]; other site
216597007136	TPP binding site [chemical binding]; other site
216597007137	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
216597007138	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
216597007139	TPP-binding site [chemical binding]; other site
216597007140	dimer interface [polypeptide binding]; other site
216597007141	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996
216597007142	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
216597007143	active site
216597007144	P-loop; other site
216597007145	phosphorylation site [posttranslational modification]
216597007146	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216597007147	active site
216597007148	phosphorylation site [posttranslational modification]
216597007149	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216597007150	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597007151	DNA binding site [nucleotide binding]
216597007152	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
216597007153	putative dimerization interface [polypeptide binding]; other site
216597007154	putative ligand binding site [chemical binding]; other site
216597007155	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
216597007156	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
216597007157	nudix motif; other site
216597007158	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
216597007159	active site
216597007160	metal binding site [ion binding]; metal-binding site
216597007161	homotetramer interface [polypeptide binding]; other site
216597007162	glutathione S-transferase; Provisional; Region: PRK15113
216597007163	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
216597007164	C-terminal domain interface [polypeptide binding]; other site
216597007165	GSH binding site (G-site) [chemical binding]; other site
216597007166	dimer interface [polypeptide binding]; other site
216597007167	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
216597007168	N-terminal domain interface [polypeptide binding]; other site
216597007169	putative dimer interface [polypeptide binding]; other site
216597007170	putative substrate binding pocket (H-site) [chemical binding]; other site
216597007171	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
216597007172	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
216597007173	C-terminal domain interface [polypeptide binding]; other site
216597007174	GSH binding site (G-site) [chemical binding]; other site
216597007175	dimer interface [polypeptide binding]; other site
216597007176	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
216597007177	N-terminal domain interface [polypeptide binding]; other site
216597007178	putative dimer interface [polypeptide binding]; other site
216597007179	active site
216597007180	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
216597007181	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
216597007182	putative NAD(P) binding site [chemical binding]; other site
216597007183	putative active site [active]
216597007184	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
216597007185	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216597007186	Walker A/P-loop; other site
216597007187	ATP binding site [chemical binding]; other site
216597007188	Q-loop/lid; other site
216597007189	ABC transporter signature motif; other site
216597007190	Walker B; other site
216597007191	D-loop; other site
216597007192	H-loop/switch region; other site
216597007193	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216597007194	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597007195	dimer interface [polypeptide binding]; other site
216597007196	conserved gate region; other site
216597007197	putative PBP binding loops; other site
216597007198	ABC-ATPase subunit interface; other site
216597007199	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216597007200	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597007201	dimer interface [polypeptide binding]; other site
216597007202	conserved gate region; other site
216597007203	putative PBP binding loops; other site
216597007204	ABC-ATPase subunit interface; other site
216597007205	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
216597007206	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597007207	substrate binding pocket [chemical binding]; other site
216597007208	membrane-bound complex binding site; other site
216597007209	hinge residues; other site
216597007210	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
216597007211	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597007212	substrate binding pocket [chemical binding]; other site
216597007213	membrane-bound complex binding site; other site
216597007214	hinge residues; other site
216597007215	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
216597007216	Flavoprotein; Region: Flavoprotein; pfam02441
216597007217	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
216597007218	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
216597007219	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
216597007220	dimer interface [polypeptide binding]; other site
216597007221	active site
216597007222	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216597007223	substrate binding site [chemical binding]; other site
216597007224	catalytic residue [active]
216597007225	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
216597007226	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
216597007227	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
216597007228	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216597007229	catalytic residue [active]
216597007230	PAS fold; Region: PAS_4; pfam08448
216597007231	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216597007232	putative active site [active]
216597007233	heme pocket [chemical binding]; other site
216597007234	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
216597007235	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597007236	Walker A motif; other site
216597007237	ATP binding site [chemical binding]; other site
216597007238	Walker B motif; other site
216597007239	arginine finger; other site
216597007240	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216597007241	amidophosphoribosyltransferase; Provisional; Region: PRK09246
216597007242	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
216597007243	active site
216597007244	tetramer interface [polypeptide binding]; other site
216597007245	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216597007246	active site
216597007247	colicin V production protein; Provisional; Region: PRK10845
216597007248	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
216597007249	cell division protein DedD; Provisional; Region: PRK11633
216597007250	Sporulation related domain; Region: SPOR; pfam05036
216597007251	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
216597007252	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216597007253	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
216597007254	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
216597007255	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
216597007256	hypothetical protein; Provisional; Region: PRK10847
216597007257	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
216597007258	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
216597007259	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
216597007260	dimerization interface 3.5A [polypeptide binding]; other site
216597007261	active site
216597007262	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
216597007263	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
216597007264	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
216597007265	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
216597007266	ligand binding site [chemical binding]; other site
216597007267	NAD binding site [chemical binding]; other site
216597007268	catalytic site [active]
216597007269	homodimer interface [polypeptide binding]; other site
216597007270	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
216597007271	putative transporter; Provisional; Region: PRK12382
216597007272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597007273	putative substrate translocation pore; other site
216597007274	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597007275	non-specific DNA binding site [nucleotide binding]; other site
216597007276	salt bridge; other site
216597007277	sequence-specific DNA binding site [nucleotide binding]; other site
216597007278	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
216597007279	CAAX protease self-immunity; Region: Abi; pfam02517
216597007280	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
216597007281	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
216597007282	dimer interface [polypeptide binding]; other site
216597007283	active site
216597007284	Uncharacterized conserved protein [Function unknown]; Region: COG4121
216597007285	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
216597007286	YfcL protein; Region: YfcL; pfam08891
216597007287	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
216597007288	hypothetical protein; Provisional; Region: PRK10621
216597007289	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
216597007290	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
216597007291	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
216597007292	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
216597007293	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
216597007294	Tetramer interface [polypeptide binding]; other site
216597007295	active site
216597007296	FMN-binding site [chemical binding]; other site
216597007297	HemK family putative methylases; Region: hemK_fam; TIGR00536
216597007298	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597007299	S-adenosylmethionine binding site [chemical binding]; other site
216597007300	hypothetical protein; Provisional; Region: PRK04946
216597007301	Smr domain; Region: Smr; pfam01713
216597007302	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
216597007303	catalytic core [active]
216597007304	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
216597007305	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216597007306	substrate binding site [chemical binding]; other site
216597007307	oxyanion hole (OAH) forming residues; other site
216597007308	trimer interface [polypeptide binding]; other site
216597007309	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
216597007310	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
216597007311	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
216597007312	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
216597007313	dimer interface [polypeptide binding]; other site
216597007314	active site
216597007315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
216597007316	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
216597007317	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
216597007318	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
216597007319	outer membrane protease; Reviewed; Region: PRK10993
216597007320	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
216597007321	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597007322	active site
216597007323	phosphorylation site [posttranslational modification]
216597007324	intermolecular recognition site; other site
216597007325	dimerization interface [polypeptide binding]; other site
216597007326	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
216597007327	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216597007328	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
216597007329	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
216597007330	dimerization interface [polypeptide binding]; other site
216597007331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597007332	dimer interface [polypeptide binding]; other site
216597007333	phosphorylation site [posttranslational modification]
216597007334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597007335	ATP binding site [chemical binding]; other site
216597007336	Mg2+ binding site [ion binding]; other site
216597007337	G-X-G motif; other site
216597007338	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
216597007339	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
216597007340	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
216597007341	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597007342	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597007343	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
216597007344	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
216597007345	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
216597007346	putative acyl-acceptor binding pocket; other site
216597007347	aminotransferase; Validated; Region: PRK08175
216597007348	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216597007349	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597007350	homodimer interface [polypeptide binding]; other site
216597007351	catalytic residue [active]
216597007352	glucokinase; Provisional; Region: glk; PRK00292
216597007353	glucokinase, proteobacterial type; Region: glk; TIGR00749
216597007354	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
216597007355	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
216597007356	Cl- selectivity filter; other site
216597007357	Cl- binding residues [ion binding]; other site
216597007358	pore gating glutamate residue; other site
216597007359	dimer interface [polypeptide binding]; other site
216597007360	indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393
216597007361	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
216597007362	dimer interface [polypeptide binding]; other site
216597007363	PYR/PP interface [polypeptide binding]; other site
216597007364	TPP binding site [chemical binding]; other site
216597007365	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216597007366	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
216597007367	TPP-binding site [chemical binding]; other site
216597007368	dimer interface [polypeptide binding]; other site
216597007369	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216597007370	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216597007371	active site
216597007372	catalytic tetrad [active]
216597007373	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
216597007374	manganese transport protein MntH; Reviewed; Region: PRK00701
216597007375	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
216597007376	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
216597007377	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
216597007378	Nucleoside recognition; Region: Gate; pfam07670
216597007379	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
216597007380	MASE1; Region: MASE1; pfam05231
216597007381	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216597007382	diguanylate cyclase; Region: GGDEF; smart00267
216597007383	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597007384	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
216597007385	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
216597007386	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
216597007387	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
216597007388	active site
216597007389	HIGH motif; other site
216597007390	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
216597007391	active site
216597007392	KMSKS motif; other site
216597007393	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
216597007394	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597007395	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
216597007396	putative dimerization interface [polypeptide binding]; other site
216597007397	putative substrate binding pocket [chemical binding]; other site
216597007398	XapX domain; Region: XapX; TIGR03510
216597007399	nucleoside transporter; Region: 2A0110; TIGR00889
216597007400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597007401	putative substrate translocation pore; other site
216597007402	purine nucleoside phosphorylase; Provisional; Region: PRK08202
216597007403	hypothetical protein; Provisional; Region: PRK11528
216597007404	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597007405	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597007406	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
216597007407	putative dimerization interface [polypeptide binding]; other site
216597007408	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
216597007409	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
216597007410	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
216597007411	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
216597007412	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
216597007413	nucleotide binding pocket [chemical binding]; other site
216597007414	K-X-D-G motif; other site
216597007415	catalytic site [active]
216597007416	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
216597007417	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
216597007418	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
216597007419	Dimer interface [polypeptide binding]; other site
216597007420	BRCT sequence motif; other site
216597007421	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
216597007422	cell division protein ZipA; Provisional; Region: PRK03427
216597007423	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
216597007424	FtsZ protein binding site [polypeptide binding]; other site
216597007425	putative sulfate transport protein CysZ; Validated; Region: PRK04949
216597007426	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
216597007427	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
216597007428	dimer interface [polypeptide binding]; other site
216597007429	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597007430	catalytic residue [active]
216597007431	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
216597007432	dimerization domain swap beta strand [polypeptide binding]; other site
216597007433	regulatory protein interface [polypeptide binding]; other site
216597007434	active site
216597007435	regulatory phosphorylation site [posttranslational modification]; other site
216597007436	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
216597007437	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
216597007438	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
216597007439	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
216597007440	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
216597007441	HPr interaction site; other site
216597007442	glycerol kinase (GK) interaction site [polypeptide binding]; other site
216597007443	active site
216597007444	phosphorylation site [posttranslational modification]
216597007445	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
216597007446	dimer interface [polypeptide binding]; other site
216597007447	pyridoxamine kinase; Validated; Region: PRK05756
216597007448	pyridoxal binding site [chemical binding]; other site
216597007449	ATP binding site [chemical binding]; other site
216597007450	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
216597007451	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597007452	DNA-binding site [nucleotide binding]; DNA binding site
216597007453	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216597007454	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597007455	homodimer interface [polypeptide binding]; other site
216597007456	catalytic residue [active]
216597007457	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
216597007458	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
216597007459	catalytic triad [active]
216597007460	hypothetical protein; Provisional; Region: PRK10318
216597007461	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
216597007462	Transglycosylase; Region: Transgly; cl17702
216597007463	cysteine synthase B; Region: cysM; TIGR01138
216597007464	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
216597007465	dimer interface [polypeptide binding]; other site
216597007466	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597007467	catalytic residue [active]
216597007468	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
216597007469	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
216597007470	Walker A/P-loop; other site
216597007471	ATP binding site [chemical binding]; other site
216597007472	Q-loop/lid; other site
216597007473	ABC transporter signature motif; other site
216597007474	Walker B; other site
216597007475	D-loop; other site
216597007476	H-loop/switch region; other site
216597007477	TOBE-like domain; Region: TOBE_3; pfam12857
216597007478	sulfate transport protein; Provisional; Region: cysT; CHL00187
216597007479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597007480	dimer interface [polypeptide binding]; other site
216597007481	conserved gate region; other site
216597007482	putative PBP binding loops; other site
216597007483	ABC-ATPase subunit interface; other site
216597007484	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
216597007485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597007486	dimer interface [polypeptide binding]; other site
216597007487	conserved gate region; other site
216597007488	putative PBP binding loops; other site
216597007489	ABC-ATPase subunit interface; other site
216597007490	thiosulfate transporter subunit; Provisional; Region: PRK10852
216597007491	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
216597007492	short chain dehydrogenase; Provisional; Region: PRK08226
216597007493	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
216597007494	NAD binding site [chemical binding]; other site
216597007495	homotetramer interface [polypeptide binding]; other site
216597007496	homodimer interface [polypeptide binding]; other site
216597007497	active site
216597007498	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
216597007499	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
216597007500	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
216597007501	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
216597007502	putative acetyltransferase; Provisional; Region: PRK03624
216597007503	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597007504	Coenzyme A binding pocket [chemical binding]; other site
216597007505	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
216597007506	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
216597007507	active site
216597007508	metal binding site [ion binding]; metal-binding site
216597007509	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
216597007510	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
216597007511	transcriptional regulator EutR; Provisional; Region: PRK10130
216597007512	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597007513	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597007514	carboxysome structural protein EutK; Provisional; Region: PRK15466
216597007515	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
216597007516	Hexamer interface [polypeptide binding]; other site
216597007517	Hexagonal pore residue; other site
216597007518	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
216597007519	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
216597007520	putative hexamer interface [polypeptide binding]; other site
216597007521	putative hexagonal pore; other site
216597007522	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
216597007523	putative hexamer interface [polypeptide binding]; other site
216597007524	putative hexagonal pore; other site
216597007525	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
216597007526	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
216597007527	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
216597007528	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
216597007529	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
216597007530	ethanol dehydrogenase EutG; Provisional; Region: PRK15454
216597007531	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
216597007532	active site
216597007533	metal binding site [ion binding]; metal-binding site
216597007534	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
216597007535	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
216597007536	nucleotide binding site [chemical binding]; other site
216597007537	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
216597007538	putative catalytic cysteine [active]
216597007539	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
216597007540	Hexamer/Pentamer interface [polypeptide binding]; other site
216597007541	central pore; other site
216597007542	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
216597007543	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
216597007544	Hexamer interface [polypeptide binding]; other site
216597007545	Putative hexagonal pore residue; other site
216597007546	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
216597007547	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
216597007548	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
216597007549	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766
216597007550	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
216597007551	G1 box; other site
216597007552	GTP/Mg2+ binding site [chemical binding]; other site
216597007553	G2 box; other site
216597007554	Switch I region; other site
216597007555	G3 box; other site
216597007556	Switch II region; other site
216597007557	G4 box; other site
216597007558	G5 box; other site
216597007559	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
216597007560	putative hexamer interface [polypeptide binding]; other site
216597007561	putative hexagonal pore; other site
216597007562	Transposase IS200 like; Region: Y1_Tnp; pfam01797
216597007563	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
216597007564	Malic enzyme, N-terminal domain; Region: malic; pfam00390
216597007565	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
216597007566	putative NAD(P) binding site [chemical binding]; other site
216597007567	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
216597007568	transaldolase-like protein; Provisional; Region: PTZ00411
216597007569	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
216597007570	active site
216597007571	dimer interface [polypeptide binding]; other site
216597007572	catalytic residue [active]
216597007573	transketolase; Reviewed; Region: PRK12753
216597007574	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
216597007575	TPP-binding site [chemical binding]; other site
216597007576	dimer interface [polypeptide binding]; other site
216597007577	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
216597007578	PYR/PP interface [polypeptide binding]; other site
216597007579	dimer interface [polypeptide binding]; other site
216597007580	TPP binding site [chemical binding]; other site
216597007581	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
216597007582	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
216597007583	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
216597007584	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
216597007585	dimer interface [polypeptide binding]; other site
216597007586	ADP-ribose binding site [chemical binding]; other site
216597007587	active site
216597007588	nudix motif; other site
216597007589	metal binding site [ion binding]; metal-binding site
216597007590	putative periplasmic esterase; Provisional; Region: PRK03642
216597007591	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
216597007592	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
216597007593	4Fe-4S binding domain; Region: Fer4; pfam00037
216597007594	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216597007595	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216597007596	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
216597007597	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
216597007598	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597007599	dimerization interface [polypeptide binding]; other site
216597007600	Histidine kinase; Region: HisKA_3; pfam07730
216597007601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597007602	ATP binding site [chemical binding]; other site
216597007603	Mg2+ binding site [ion binding]; other site
216597007604	G-X-G motif; other site
216597007605	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
216597007606	Protein export membrane protein; Region: SecD_SecF; cl14618
216597007607	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
216597007608	ArsC family; Region: ArsC; pfam03960
216597007609	putative catalytic residues [active]
216597007610	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
216597007611	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
216597007612	metal binding site [ion binding]; metal-binding site
216597007613	dimer interface [polypeptide binding]; other site
216597007614	hypothetical protein; Provisional; Region: PRK13664
216597007615	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
216597007616	Helicase; Region: Helicase_RecD; pfam05127
216597007617	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
216597007618	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
216597007619	Predicted metalloprotease [General function prediction only]; Region: COG2321
216597007620	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
216597007621	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
216597007622	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
216597007623	ATP binding site [chemical binding]; other site
216597007624	active site
216597007625	substrate binding site [chemical binding]; other site
216597007626	lipoprotein; Provisional; Region: PRK11679
216597007627	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
216597007628	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
216597007629	dihydrodipicolinate synthase; Region: dapA; TIGR00674
216597007630	dimer interface [polypeptide binding]; other site
216597007631	active site
216597007632	catalytic residue [active]
216597007633	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
216597007634	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
216597007635	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
216597007636	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
216597007637	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
216597007638	catalytic triad [active]
216597007639	Glycerate kinase family; Region: Gly_kinase; cl00841
216597007640	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
216597007641	Domain of unknown function DUF20; Region: UPF0118; pfam01594
216597007642	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
216597007643	Peptidase family M48; Region: Peptidase_M48; cl12018
216597007644	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
216597007645	ArsC family; Region: ArsC; pfam03960
216597007646	catalytic residues [active]
216597007647	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
216597007648	DNA replication initiation factor; Provisional; Region: PRK08084
216597007649	uracil transporter; Provisional; Region: PRK10720
216597007650	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216597007651	active site
216597007652	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
216597007653	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
216597007654	dimerization interface [polypeptide binding]; other site
216597007655	putative ATP binding site [chemical binding]; other site
216597007656	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
216597007657	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
216597007658	active site
216597007659	substrate binding site [chemical binding]; other site
216597007660	cosubstrate binding site; other site
216597007661	catalytic site [active]
216597007662	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
216597007663	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
216597007664	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
216597007665	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
216597007666	putative active site [active]
216597007667	catalytic site [active]
216597007668	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
216597007669	domain interface [polypeptide binding]; other site
216597007670	active site
216597007671	catalytic site [active]
216597007672	exopolyphosphatase; Provisional; Region: PRK10854
216597007673	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
216597007674	nucleotide binding site [chemical binding]; other site
216597007675	MASE1; Region: MASE1; pfam05231
216597007676	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216597007677	diguanylate cyclase; Region: GGDEF; smart00267
216597007678	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597007679	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
216597007680	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
216597007681	Integrase core domain; Region: rve; pfam00665
216597007682	GMP synthase; Reviewed; Region: guaA; PRK00074
216597007683	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
216597007684	AMP/PPi binding site [chemical binding]; other site
216597007685	candidate oxyanion hole; other site
216597007686	catalytic triad [active]
216597007687	potential glutamine specificity residues [chemical binding]; other site
216597007688	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
216597007689	ATP Binding subdomain [chemical binding]; other site
216597007690	Ligand Binding sites [chemical binding]; other site
216597007691	Dimerization subdomain; other site
216597007692	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
216597007693	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
216597007694	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
216597007695	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
216597007696	active site
216597007697	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
216597007698	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
216597007699	generic binding surface II; other site
216597007700	generic binding surface I; other site
216597007701	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
216597007702	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
216597007703	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
216597007704	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
216597007705	Autotransporter beta-domain; Region: Autotransporter; smart00869
216597007707	outer membrane protein RatA; Provisional; Region: PRK15315
216597007708	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
216597007709	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
216597007710	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
216597007711	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
216597007712	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
216597007713	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
216597007714	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
216597007715	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
216597007716	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
216597007717	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
216597007718	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
216597007719	intimin-like protein SinH; Provisional; Region: PRK15318
216597007720	intimin-like protein SinH; Provisional; Region: PRK15318
216597007721	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
216597007722	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
216597007723	GTP-binding protein Der; Reviewed; Region: PRK00093
216597007724	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
216597007725	G1 box; other site
216597007726	GTP/Mg2+ binding site [chemical binding]; other site
216597007727	Switch I region; other site
216597007728	G2 box; other site
216597007729	Switch II region; other site
216597007730	G3 box; other site
216597007731	G4 box; other site
216597007732	G5 box; other site
216597007733	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
216597007734	G1 box; other site
216597007735	GTP/Mg2+ binding site [chemical binding]; other site
216597007736	Switch I region; other site
216597007737	G2 box; other site
216597007738	G3 box; other site
216597007739	Switch II region; other site
216597007740	G4 box; other site
216597007741	G5 box; other site
216597007742	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
216597007743	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
216597007744	Trp docking motif [polypeptide binding]; other site
216597007745	active site
216597007746	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
216597007747	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
216597007748	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
216597007749	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
216597007750	dimer interface [polypeptide binding]; other site
216597007751	motif 1; other site
216597007752	active site
216597007753	motif 2; other site
216597007754	motif 3; other site
216597007755	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
216597007756	anticodon binding site; other site
216597007757	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
216597007758	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
216597007759	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
216597007760	cytoskeletal protein RodZ; Provisional; Region: PRK10856
216597007761	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597007762	non-specific DNA binding site [nucleotide binding]; other site
216597007763	salt bridge; other site
216597007764	sequence-specific DNA binding site [nucleotide binding]; other site
216597007765	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
216597007766	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
216597007767	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597007768	FeS/SAM binding site; other site
216597007769	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
216597007770	active site
216597007771	multimer interface [polypeptide binding]; other site
216597007772	4Fe-4S binding domain; Region: Fer4; pfam00037
216597007773	hydrogenase 4 subunit H; Validated; Region: PRK08222
216597007774	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
216597007775	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
216597007776	4Fe-4S binding domain; Region: Fer4; pfam00037
216597007777	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
216597007778	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
216597007779	putative [Fe4-S4] binding site [ion binding]; other site
216597007780	putative molybdopterin cofactor binding site [chemical binding]; other site
216597007781	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
216597007782	putative molybdopterin cofactor binding site; other site
216597007783	penicillin-binding protein 1C; Provisional; Region: PRK11240
216597007784	Transglycosylase; Region: Transgly; pfam00912
216597007785	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
216597007786	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
216597007787	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
216597007788	MG2 domain; Region: A2M_N; pfam01835
216597007789	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
216597007790	surface patch; other site
216597007791	thioester region; other site
216597007792	specificity defining residues; other site
216597007793	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
216597007794	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
216597007795	active site residue [active]
216597007796	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
216597007797	active site residue [active]
216597007798	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
216597007799	aminopeptidase B; Provisional; Region: PRK05015
216597007800	Peptidase; Region: DUF3663; pfam12404
216597007801	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
216597007802	interface (dimer of trimers) [polypeptide binding]; other site
216597007803	Substrate-binding/catalytic site; other site
216597007804	Zn-binding sites [ion binding]; other site
216597007805	hypothetical protein; Provisional; Region: PRK10721
216597007806	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
216597007807	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216597007808	catalytic loop [active]
216597007809	iron binding site [ion binding]; other site
216597007810	chaperone protein HscA; Provisional; Region: hscA; PRK05183
216597007811	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
216597007812	nucleotide binding site [chemical binding]; other site
216597007813	putative NEF/HSP70 interaction site [polypeptide binding]; other site
216597007814	SBD interface [polypeptide binding]; other site
216597007815	co-chaperone HscB; Provisional; Region: hscB; PRK05014
216597007816	DnaJ domain; Region: DnaJ; pfam00226
216597007817	HSP70 interaction site [polypeptide binding]; other site
216597007818	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
216597007819	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
216597007820	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
216597007821	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
216597007822	trimerization site [polypeptide binding]; other site
216597007823	active site
216597007824	cysteine desulfurase; Provisional; Region: PRK14012
216597007825	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
216597007826	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216597007827	catalytic residue [active]
216597007828	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
216597007829	Rrf2 family protein; Region: rrf2_super; TIGR00738
216597007830	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
216597007831	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
216597007832	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
216597007833	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
216597007834	active site
216597007835	dimerization interface [polypeptide binding]; other site
216597007836	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
216597007837	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216597007838	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
216597007839	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
216597007840	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
216597007841	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
216597007842	FAD binding pocket [chemical binding]; other site
216597007843	FAD binding motif [chemical binding]; other site
216597007844	phosphate binding motif [ion binding]; other site
216597007845	beta-alpha-beta structure motif; other site
216597007846	NAD binding pocket [chemical binding]; other site
216597007847	Iron coordination center [ion binding]; other site
216597007848	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
216597007849	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
216597007850	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
216597007851	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
216597007852	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
216597007853	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
216597007854	PRD domain; Region: PRD; pfam00874
216597007855	PRD domain; Region: PRD; pfam00874
216597007856	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
216597007857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597007858	putative substrate translocation pore; other site
216597007859	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
216597007860	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
216597007861	dimer interface [polypeptide binding]; other site
216597007862	active site
216597007863	glycine-pyridoxal phosphate binding site [chemical binding]; other site
216597007864	folate binding site [chemical binding]; other site
216597007865	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
216597007866	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
216597007867	heme-binding site [chemical binding]; other site
216597007868	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
216597007869	FAD binding pocket [chemical binding]; other site
216597007870	FAD binding motif [chemical binding]; other site
216597007871	phosphate binding motif [ion binding]; other site
216597007872	beta-alpha-beta structure motif; other site
216597007873	NAD binding pocket [chemical binding]; other site
216597007874	Heme binding  pocket [chemical binding]; other site
216597007875	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
216597007876	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597007877	DNA binding site [nucleotide binding]
216597007878	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
216597007879	lysine decarboxylase CadA; Provisional; Region: PRK15400
216597007880	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
216597007881	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
216597007882	homodimer interface [polypeptide binding]; other site
216597007883	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597007884	catalytic residue [active]
216597007885	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
216597007886	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
216597007887	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597007888	putative substrate translocation pore; other site
216597007889	POT family; Region: PTR2; pfam00854
216597007890	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
216597007891	Nitrogen regulatory protein P-II; Region: P-II; smart00938
216597007892	response regulator GlrR; Provisional; Region: PRK15115
216597007893	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597007894	active site
216597007895	phosphorylation site [posttranslational modification]
216597007896	intermolecular recognition site; other site
216597007897	dimerization interface [polypeptide binding]; other site
216597007898	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597007899	Walker A motif; other site
216597007900	ATP binding site [chemical binding]; other site
216597007901	Walker B motif; other site
216597007902	arginine finger; other site
216597007903	hypothetical protein; Provisional; Region: PRK10722
216597007904	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216597007905	HAMP domain; Region: HAMP; pfam00672
216597007906	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597007907	dimer interface [polypeptide binding]; other site
216597007908	phosphorylation site [posttranslational modification]
216597007909	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597007910	ATP binding site [chemical binding]; other site
216597007911	Mg2+ binding site [ion binding]; other site
216597007912	G-X-G motif; other site
216597007913	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
216597007914	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
216597007915	dimerization interface [polypeptide binding]; other site
216597007916	ATP binding site [chemical binding]; other site
216597007917	Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193
216597007918	dimerization interface [polypeptide binding]; other site
216597007919	ATP binding site [chemical binding]; other site
216597007920	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
216597007921	putative active site [active]
216597007922	catalytic triad [active]
216597007923	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
216597007924	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597007925	substrate binding pocket [chemical binding]; other site
216597007926	membrane-bound complex binding site; other site
216597007927	hinge residues; other site
216597007928	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216597007929	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216597007930	catalytic residue [active]
216597007931	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
216597007932	nucleoside/Zn binding site; other site
216597007933	dimer interface [polypeptide binding]; other site
216597007934	catalytic motif [active]
216597007935	hypothetical protein; Provisional; Region: PRK11590
216597007936	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
216597007937	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
216597007938	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
216597007939	active site turn [active]
216597007940	phosphorylation site [posttranslational modification]
216597007941	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
216597007942	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
216597007943	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
216597007944	putative active site [active]
216597007945	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
216597007946	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
216597007947	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
216597007948	putative active site [active]
216597007949	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
216597007950	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
216597007951	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
216597007952	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
216597007953	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597007954	putative substrate translocation pore; other site
216597007955	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597007956	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597007957	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216597007958	dimerization interface [polypeptide binding]; other site
216597007959	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
216597007960	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
216597007961	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
216597007962	active site
216597007963	hydrophilic channel; other site
216597007964	dimerization interface [polypeptide binding]; other site
216597007965	catalytic residues [active]
216597007966	active site lid [active]
216597007967	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
216597007968	Recombination protein O N terminal; Region: RecO_N; pfam11967
216597007969	Recombination protein O C terminal; Region: RecO_C; pfam02565
216597007970	GTPase Era; Reviewed; Region: era; PRK00089
216597007971	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
216597007972	G1 box; other site
216597007973	GTP/Mg2+ binding site [chemical binding]; other site
216597007974	Switch I region; other site
216597007975	G2 box; other site
216597007976	Switch II region; other site
216597007977	G3 box; other site
216597007978	G4 box; other site
216597007979	G5 box; other site
216597007980	KH domain; Region: KH_2; pfam07650
216597007981	ribonuclease III; Reviewed; Region: rnc; PRK00102
216597007982	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
216597007983	dimerization interface [polypeptide binding]; other site
216597007984	active site
216597007985	metal binding site [ion binding]; metal-binding site
216597007986	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
216597007987	dsRNA binding site [nucleotide binding]; other site
216597007988	signal peptidase I; Provisional; Region: PRK10861
216597007989	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
216597007990	Catalytic site [active]
216597007991	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
216597007992	GTP-binding protein LepA; Provisional; Region: PRK05433
216597007993	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
216597007994	G1 box; other site
216597007995	putative GEF interaction site [polypeptide binding]; other site
216597007996	GTP/Mg2+ binding site [chemical binding]; other site
216597007997	Switch I region; other site
216597007998	G2 box; other site
216597007999	G3 box; other site
216597008000	Switch II region; other site
216597008001	G4 box; other site
216597008002	G5 box; other site
216597008003	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
216597008004	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
216597008005	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
216597008006	type III secretion protein GogB; Provisional; Region: PRK15386
216597008007	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
216597008008	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
216597008009	Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900
216597008010	ADP-ribose binding site [chemical binding]; other site
216597008011	putative active site [active]
216597008012	dimer interface [polypeptide binding]; other site
216597008013	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
216597008014	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
216597008015	Phage Tail Collar Domain; Region: Collar; pfam07484
216597008016	Phage-related protein, tail component [Function unknown]; Region: COG4733
216597008017	Putative phage tail protein; Region: Phage-tail_3; pfam13550
216597008018	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
216597008019	Interdomain contacts; other site
216597008020	Cytokine receptor motif; other site
216597008021	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
216597008022	Fibronectin type III protein; Region: DUF3672; pfam12421
216597008023	Phage-related protein, tail component [Function unknown]; Region: COG4723
216597008024	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
216597008025	MPN+ (JAMM) motif; other site
216597008026	Zinc-binding site [ion binding]; other site
216597008027	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
216597008028	NlpC/P60 family; Region: NLPC_P60; cl17555
216597008029	Phage-related protein [Function unknown]; Region: gp18; COG4672
216597008030	Phage-related protein [Function unknown]; Region: COG4718
216597008031	Phage-related minor tail protein [Function unknown]; Region: COG5281
216597008032	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
216597008033	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
216597008034	Minor tail protein T; Region: Phage_tail_T; pfam06223
216597008035	Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894
216597008036	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
216597008037	Phage tail protein; Region: Phage_tail_3; pfam08813
216597008038	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
216597008039	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
216597008040	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
216597008041	Probable transposase; Region: OrfB_IS605; pfam01385
216597008042	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
216597008043	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
216597008044	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094
216597008045	DNA packaging protein FI; Region: Packaging_FI; pfam14000
216597008046	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
216597008047	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
216597008048	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
216597008049	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
216597008050	tandem repeat interface [polypeptide binding]; other site
216597008051	oligomer interface [polypeptide binding]; other site
216597008052	active site residues [active]
216597008053	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
216597008054	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
216597008055	gpW; Region: gpW; pfam02831
216597008056	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
216597008057	Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471
216597008058	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
216597008059	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
216597008060	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
216597008061	catalytic residues [active]
216597008062	PipA protein; Region: PipA; pfam07108
216597008063	ORF6N domain; Region: ORF6N; pfam10543
216597008064	Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323
216597008065	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
216597008066	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
216597008067	DinI-like family; Region: DinI; pfam06183
216597008068	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
216597008069	Protein of unknown function (DUF550); Region: DUF550; pfam04447
216597008070	Protein of unknown function (DUF551); Region: DUF551; pfam04448
216597008071	Methyltransferase domain; Region: Methyltransf_25; pfam13649
216597008072	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
216597008073	Replication protein P; Region: Phage_lambda_P; pfam06992
216597008074	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
216597008075	Bacteriophage CII protein; Region: Phage_CII; pfam05269
216597008076	transcriptional repressor DicA; Reviewed; Region: PRK09706
216597008077	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597008078	non-specific DNA binding site [nucleotide binding]; other site
216597008079	sequence-specific DNA binding site [nucleotide binding]; other site
216597008080	salt bridge; other site
216597008081	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
216597008082	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
216597008083	P-loop; other site
216597008084	Magnesium ion binding site [ion binding]; other site
216597008085	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
216597008086	Magnesium ion binding site [ion binding]; other site
216597008088	exonuclease VIII; Reviewed; Region: PRK09709
216597008089	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
216597008090	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
216597008091	RecT family; Region: RecT; pfam03837
216597008092	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
216597008093	integrase; Provisional; Region: PRK09692
216597008094	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
216597008095	active site
216597008096	Int/Topo IB signature motif; other site
216597008097	SoxR reducing system protein RseC; Provisional; Region: PRK10862
216597008098	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
216597008099	anti-sigma E factor; Provisional; Region: rseB; PRK09455
216597008100	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
216597008101	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
216597008102	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
216597008103	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
216597008104	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216597008105	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216597008106	DNA binding residues [nucleotide binding]
216597008107	L-aspartate oxidase; Provisional; Region: PRK09077
216597008108	L-aspartate oxidase; Provisional; Region: PRK06175
216597008109	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
216597008110	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
216597008111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597008112	S-adenosylmethionine binding site [chemical binding]; other site
216597008113	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
216597008114	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
216597008115	ATP binding site [chemical binding]; other site
216597008116	Mg++ binding site [ion binding]; other site
216597008117	motif III; other site
216597008118	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597008119	nucleotide binding region [chemical binding]; other site
216597008120	ATP-binding site [chemical binding]; other site
216597008121	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597008122	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597008123	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216597008124	dimerization interface [polypeptide binding]; other site
216597008125	cysteine/O-acetylserine exporter; Provisional; Region: PRK10323
216597008126	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
216597008127	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
216597008128	ligand binding site [chemical binding]; other site
216597008129	active site
216597008130	UGI interface [polypeptide binding]; other site
216597008131	catalytic site [active]
216597008132	putative methyltransferase; Provisional; Region: PRK10864
216597008133	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
216597008134	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
216597008135	thioredoxin 2; Provisional; Region: PRK10996
216597008136	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
216597008137	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
216597008138	catalytic residues [active]
216597008139	Uncharacterized conserved protein [Function unknown]; Region: COG3148
216597008140	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
216597008141	CoA binding domain; Region: CoA_binding_2; pfam13380
216597008142	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
216597008143	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
216597008144	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
216597008145	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597008146	Coenzyme A binding pocket [chemical binding]; other site
216597008147	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
216597008148	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
216597008149	domain interface [polypeptide binding]; other site
216597008150	putative active site [active]
216597008151	catalytic site [active]
216597008152	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
216597008153	domain interface [polypeptide binding]; other site
216597008154	putative active site [active]
216597008155	catalytic site [active]
216597008156	lipoprotein; Provisional; Region: PRK10759
216597008157	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
216597008158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597008159	putative substrate translocation pore; other site
216597008160	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
216597008161	protein disaggregation chaperone; Provisional; Region: PRK10865
216597008162	Clp amino terminal domain; Region: Clp_N; pfam02861
216597008163	Clp amino terminal domain; Region: Clp_N; pfam02861
216597008164	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597008165	Walker A motif; other site
216597008166	ATP binding site [chemical binding]; other site
216597008167	Walker B motif; other site
216597008168	arginine finger; other site
216597008169	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597008170	Walker A motif; other site
216597008171	ATP binding site [chemical binding]; other site
216597008172	Walker B motif; other site
216597008173	arginine finger; other site
216597008174	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
216597008175	hypothetical protein; Provisional; Region: PRK10723
216597008176	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
216597008177	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
216597008178	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216597008179	RNA binding surface [nucleotide binding]; other site
216597008180	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
216597008181	active site
216597008182	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
216597008183	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
216597008184	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
216597008185	30S subunit binding site; other site
216597008186	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
216597008187	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
216597008188	Prephenate dehydratase; Region: PDT; pfam00800
216597008189	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
216597008190	putative L-Phe binding site [chemical binding]; other site
216597008191	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
216597008192	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
216597008193	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
216597008194	prephenate dehydrogenase; Validated; Region: PRK08507
216597008195	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
216597008196	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
216597008197	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
216597008198	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
216597008199	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216597008200	metal binding site [ion binding]; metal-binding site
216597008201	active site
216597008202	I-site; other site
216597008203	integrase; Provisional; Region: int; PHA02601
216597008204	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216597008205	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216597008206	active site
216597008207	DNA binding site [nucleotide binding]
216597008208	Int/Topo IB signature motif; other site
216597008209	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
216597008210	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
216597008211	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
216597008212	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
216597008213	Protein of unknown function (DUF2724); Region: DUF2724; pfam10893
216597008214	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
216597008215	DksA-like zinc finger domain containing protein; Region: PHA00080
216597008216	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
216597008217	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
216597008218	tail protein; Provisional; Region: D; PHA02561
216597008219	DNA-binding transcriptional regulator; Provisional; Region: PRK09678
216597008220	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
216597008221	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
216597008222	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
216597008223	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
216597008224	RimM N-terminal domain; Region: RimM; pfam01782
216597008225	PRC-barrel domain; Region: PRC; pfam05239
216597008226	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
216597008227	signal recognition particle protein; Provisional; Region: PRK10867
216597008228	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
216597008229	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
216597008230	P loop; other site
216597008231	GTP binding site [chemical binding]; other site
216597008232	Signal peptide binding domain; Region: SRP_SPB; pfam02978
216597008233	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
216597008234	hypothetical protein; Provisional; Region: PRK11573
216597008235	Domain of unknown function DUF21; Region: DUF21; pfam01595
216597008236	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
216597008237	Transporter associated domain; Region: CorC_HlyC; smart01091
216597008238	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
216597008239	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
216597008240	dimer interface [polypeptide binding]; other site
216597008241	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
216597008242	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
216597008243	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
216597008244	recombination and repair protein; Provisional; Region: PRK10869
216597008245	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
216597008246	Walker A/P-loop; other site
216597008247	ATP binding site [chemical binding]; other site
216597008248	Q-loop/lid; other site
216597008249	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
216597008250	ABC transporter signature motif; other site
216597008251	Walker B; other site
216597008252	D-loop; other site
216597008253	H-loop/switch region; other site
216597008254	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
216597008255	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
216597008256	hypothetical protein; Validated; Region: PRK01777
216597008257	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
216597008258	putative coenzyme Q binding site [chemical binding]; other site
216597008259	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
216597008260	SmpB-tmRNA interface; other site
216597008261	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008262	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008263	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008264	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008265	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008266	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008267	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008268	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008269	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008270	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008271	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008272	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
216597008273	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008274	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008275	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
216597008276	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008277	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597008278	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
216597008279	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
216597008280	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
216597008281	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216597008282	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597008283	Walker A/P-loop; other site
216597008284	ATP binding site [chemical binding]; other site
216597008285	Q-loop/lid; other site
216597008286	ABC transporter signature motif; other site
216597008287	Walker B; other site
216597008288	D-loop; other site
216597008289	H-loop/switch region; other site
216597008290	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
216597008291	HlyD family secretion protein; Region: HlyD_3; pfam13437
216597008292	DNA-binding transcriptional regulator; Provisional; Region: PRK09678
216597008293	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
216597008294	tail protein; Provisional; Region: D; PHA02561
216597008295	Phage protein U [General function prediction only]; Region: COG3499
216597008296	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
216597008297	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
216597008298	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
216597008299	major tail tube protein; Provisional; Region: FII; PHA02600
216597008300	major tail sheath protein; Provisional; Region: FI; PHA02560
216597008301	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
216597008302	type III secretion protein SopE; Provisional; Region: PRK15279
216597008303	Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364
216597008304	SopE GEF domain; Region: SopE_GEF; pfam07487
216597008305	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
216597008306	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
216597008307	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
216597008308	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
216597008309	baseplate assembly protein; Provisional; Region: J; PHA02568
216597008310	baseplate wedge subunit; Provisional; Region: W; PHA02516
216597008311	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
216597008312	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
216597008313	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
216597008314	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
216597008315	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
216597008316	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
216597008317	catalytic residues [active]
216597008318	P2-like prophage tail protein X [General function prediction only]; Region: COG5004
216597008319	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
216597008320	terminase endonuclease subunit; Provisional; Region: M; PHA02537
216597008321	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
216597008322	capsid protein; Provisional; Region: N; PHA02538
216597008323	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929
216597008324	terminase ATPase subunit; Provisional; Region: P; PHA02535
216597008325	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
216597008326	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
216597008327	portal vertex protein; Provisional; Region: Q; PHA02536
216597008328	Phage portal protein; Region: Phage_portal; pfam04860
216597008329	DNA protecting protein DprA; Region: dprA; TIGR00732
216597008330	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
216597008331	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
216597008332	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216597008333	active site
216597008334	Uncharacterized conserved protein [Function unknown]; Region: COG4933
216597008335	DinI-like family; Region: DinI; pfam06183
216597008336	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
216597008337	DNA adenine methylase (dam); Region: dam; TIGR00571
216597008338	DksA-like zinc finger domain containing protein; Region: PHA00080
216597008339	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
216597008340	Protein of unknown function (DUF2724); Region: DUF2724; pfam10893
216597008341	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
216597008342	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
216597008343	Predicted transcriptional regulator [Transcription]; Region: COG2932
216597008344	integrase; Provisional; Region: int; PHA02601
216597008345	Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family.  They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797
216597008346	dimer interface [polypeptide binding]; other site
216597008347	active site
216597008348	catalytic residues [active]
216597008349	Int/Topo IB signature motif; other site
216597008350	GrpE; Region: GrpE; pfam01025
216597008351	region highly similar to CT18 ST46 P4-family bacteriophage
216597008352	integrase; Provisional; Region: PRK09692
216597008353	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
216597008354	active site
216597008355	Int/Topo IB signature motif; other site
216597008356	Predicted ATPase [General function prediction only]; Region: COG5293
216597008357	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
216597008358	Phage polarity suppression protein (Psu); Region: Psu; pfam07455
216597008359	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
216597008360	Ash protein family; Region: Phage_ASH; pfam10554
216597008361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
216597008362	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
216597008363	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
216597008364	active site
216597008365	metal binding site [ion binding]; metal-binding site
216597008366	interdomain interaction site; other site
216597008367	D5 N terminal like; Region: D5_N; smart00885
216597008368	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
216597008369	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
216597008371	SEC-C motif; Region: SEC-C; pfam02810
216597008372	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
216597008373	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
216597008374	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
216597008375	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216597008376	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597008377	non-specific DNA binding site [nucleotide binding]; other site
216597008378	salt bridge; other site
216597008379	sequence-specific DNA binding site [nucleotide binding]; other site
216597008380	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
216597008381	Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730
216597008382	Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731
216597008383	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
216597008384	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
216597008385	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
216597008386	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
216597008387	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216597008388	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
216597008389	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
216597008390	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
216597008391	active site
216597008392	dimer interface [polypeptide binding]; other site
216597008393	magnesium binding site [ion binding]; other site
216597008394	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
216597008395	tetramer interface [polypeptide binding]; other site
216597008396	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
216597008397	active site
216597008398	Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140
216597008399	Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560
216597008400	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
216597008401	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
216597008402	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
216597008403	active site turn [active]
216597008404	phosphorylation site [posttranslational modification]
216597008405	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
216597008406	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
216597008407	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
216597008408	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
216597008409	Integrase; Region: Integrase_1; pfam12835
216597008412	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
216597008413	DNA-binding interface [nucleotide binding]; DNA binding site
216597008414	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
216597008415	Family description; Region: UvrD_C_2; pfam13538
216597008416	Transposase; Region: HTH_Tnp_1; cl17663
216597008417	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
216597008418	putative transposase OrfB; Reviewed; Region: PHA02517
216597008419	HTH-like domain; Region: HTH_21; pfam13276
216597008420	Integrase core domain; Region: rve; pfam00665
216597008421	Integrase core domain; Region: rve_2; pfam13333
216597008422	Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614
216597008423	flagellin; Validated; Region: PRK08026
216597008424	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
216597008425	Flagellin D3 domain; Region: Flagellin_D3; pfam08884
216597008426	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
216597008427	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
216597008428	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
216597008429	catalytic residues [active]
216597008430	catalytic nucleophile [active]
216597008431	Presynaptic Site I dimer interface [polypeptide binding]; other site
216597008432	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
216597008433	Synaptic Flat tetramer interface [polypeptide binding]; other site
216597008434	Synaptic Site I dimer interface [polypeptide binding]; other site
216597008435	DNA binding site [nucleotide binding]
216597008436	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
216597008437	DNA-binding interface [nucleotide binding]; DNA binding site
216597008438	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
216597008439	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
216597008440	homodimer interface [polypeptide binding]; other site
216597008441	active site
216597008442	TDP-binding site; other site
216597008443	acceptor substrate-binding pocket; other site
216597008444	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216597008445	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597008446	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
216597008447	Walker A/P-loop; other site
216597008448	ATP binding site [chemical binding]; other site
216597008449	Q-loop/lid; other site
216597008450	ABC transporter signature motif; other site
216597008451	Walker B; other site
216597008452	D-loop; other site
216597008453	H-loop/switch region; other site
216597008454	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
216597008455	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216597008456	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597008457	Walker A/P-loop; other site
216597008458	ATP binding site [chemical binding]; other site
216597008459	Q-loop/lid; other site
216597008460	ABC transporter signature motif; other site
216597008461	Walker B; other site
216597008462	D-loop; other site
216597008463	H-loop/switch region; other site
216597008464	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
216597008465	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
216597008466	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
216597008467	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
216597008468	outer membrane receptor FepA; Provisional; Region: PRK13528
216597008469	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216597008470	N-terminal plug; other site
216597008471	ligand-binding site [chemical binding]; other site
216597008472	secreted effector protein PipB2; Provisional; Region: PRK15196
216597008473	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
216597008474	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
216597008475	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
216597008476	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
216597008477	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
216597008478	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
216597008479	antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312
216597008480	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
216597008481	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
216597008482	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
216597008483	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216597008484	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
216597008485	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597008486	dimer interface [polypeptide binding]; other site
216597008487	phosphorylation site [posttranslational modification]
216597008488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597008489	ATP binding site [chemical binding]; other site
216597008490	Mg2+ binding site [ion binding]; other site
216597008491	G-X-G motif; other site
216597008492	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
216597008493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597008494	active site
216597008495	phosphorylation site [posttranslational modification]
216597008496	intermolecular recognition site; other site
216597008497	dimerization interface [polypeptide binding]; other site
216597008498	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597008499	DNA binding site [nucleotide binding]
216597008500	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
216597008501	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
216597008502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
216597008503	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
216597008504	substrate binding pocket [chemical binding]; other site
216597008505	active site
216597008506	iron coordination sites [ion binding]; other site
216597008507	Predicted dehydrogenase [General function prediction only]; Region: COG0579
216597008508	hydroxyglutarate oxidase; Provisional; Region: PRK11728
216597008509	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
216597008510	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
216597008511	tetramerization interface [polypeptide binding]; other site
216597008512	NAD(P) binding site [chemical binding]; other site
216597008513	catalytic residues [active]
216597008514	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
216597008515	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216597008516	inhibitor-cofactor binding pocket; inhibition site
216597008517	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597008518	catalytic residue [active]
216597008519	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
216597008520	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
216597008521	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597008522	DNA-binding site [nucleotide binding]; DNA binding site
216597008523	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216597008524	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
216597008525	bacterial OsmY and nodulation domain; Region: BON; smart00749
216597008526	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216597008527	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
216597008528	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216597008529	dimerization interface [polypeptide binding]; other site
216597008530	putative DNA binding site [nucleotide binding]; other site
216597008531	Transcriptional regulators [Transcription]; Region: MarR; COG1846
216597008532	putative Zn2+ binding site [ion binding]; other site
216597008533	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
216597008534	active site residue [active]
216597008535	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
216597008536	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
216597008537	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
216597008538	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
216597008539	hypothetical protein; Provisional; Region: PRK10556
216597008540	hypothetical protein; Provisional; Region: PRK10132
216597008541	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
216597008542	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597008543	DNA-binding site [nucleotide binding]; DNA binding site
216597008544	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216597008545	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597008546	homodimer interface [polypeptide binding]; other site
216597008547	catalytic residue [active]
216597008548	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
216597008549	Uncharacterized conserved protein [Function unknown]; Region: COG2128
216597008550	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
216597008551	catalytic residues [active]
216597008552	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
216597008553	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
216597008554	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
216597008555	Class I ribonucleotide reductase; Region: RNR_I; cd01679
216597008556	active site
216597008557	dimer interface [polypeptide binding]; other site
216597008558	catalytic residues [active]
216597008559	effector binding site; other site
216597008560	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
216597008561	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
216597008562	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
216597008563	dimer interface [polypeptide binding]; other site
216597008564	putative radical transfer pathway; other site
216597008565	diiron center [ion binding]; other site
216597008566	tyrosyl radical; other site
216597008567	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
216597008568	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
216597008569	Walker A/P-loop; other site
216597008570	ATP binding site [chemical binding]; other site
216597008571	Q-loop/lid; other site
216597008572	ABC transporter signature motif; other site
216597008573	Walker B; other site
216597008574	D-loop; other site
216597008575	H-loop/switch region; other site
216597008576	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
216597008577	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
216597008578	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597008579	dimer interface [polypeptide binding]; other site
216597008580	conserved gate region; other site
216597008581	putative PBP binding loops; other site
216597008582	ABC-ATPase subunit interface; other site
216597008583	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
216597008584	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
216597008585	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
216597008586	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597008587	transcriptional repressor MprA; Provisional; Region: PRK10870
216597008588	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216597008589	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
216597008590	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216597008591	HlyD family secretion protein; Region: HlyD_3; pfam13437
216597008592	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
216597008593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597008594	putative substrate translocation pore; other site
216597008595	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597008596	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
216597008597	S-ribosylhomocysteinase; Provisional; Region: PRK02260
216597008598	glutamate--cysteine ligase; Provisional; Region: PRK02107
216597008599	Predicted membrane protein [Function unknown]; Region: COG1238
216597008600	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
216597008601	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597008602	motif II; other site
216597008603	carbon storage regulator; Provisional; Region: PRK01712
216597008604	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
216597008605	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
216597008606	motif 1; other site
216597008607	active site
216597008608	motif 2; other site
216597008609	motif 3; other site
216597008610	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
216597008611	DHHA1 domain; Region: DHHA1; pfam02272
216597008612	recombination regulator RecX; Reviewed; Region: recX; PRK00117
216597008613	recombinase A; Provisional; Region: recA; PRK09354
216597008614	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
216597008615	hexamer interface [polypeptide binding]; other site
216597008616	Walker A motif; other site
216597008617	ATP binding site [chemical binding]; other site
216597008618	Walker B motif; other site
216597008619	hypothetical protein; Validated; Region: PRK03661
216597008620	Transglycosylase SLT domain; Region: SLT_2; pfam13406
216597008621	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216597008622	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216597008623	PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821
216597008624	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
216597008625	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
216597008626	Nucleoside recognition; Region: Gate; pfam07670
216597008627	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
216597008628	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
216597008629	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
216597008630	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
216597008631	putative NAD(P) binding site [chemical binding]; other site
216597008632	active site
216597008633	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
216597008634	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
216597008635	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
216597008636	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216597008637	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
216597008638	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
216597008639	putative active site [active]
216597008640	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
216597008641	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
216597008642	GAF domain; Region: GAF; pfam01590
216597008643	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597008644	Walker A motif; other site
216597008645	ATP binding site [chemical binding]; other site
216597008646	Walker B motif; other site
216597008647	arginine finger; other site
216597008648	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
216597008649	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
216597008650	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
216597008651	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
216597008652	iron binding site [ion binding]; other site
216597008653	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
216597008654	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216597008655	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216597008656	Acylphosphatase; Region: Acylphosphatase; pfam00708
216597008657	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
216597008658	HypF finger; Region: zf-HYPF; pfam07503
216597008659	HypF finger; Region: zf-HYPF; pfam07503
216597008660	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
216597008661	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
216597008662	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
216597008663	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
216597008664	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
216597008665	nickel binding site [ion binding]; other site
216597008666	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
216597008667	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
216597008668	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
216597008669	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
216597008670	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
216597008671	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
216597008672	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
216597008673	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
216597008674	NADH dehydrogenase; Region: NADHdh; cl00469
216597008675	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
216597008676	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216597008677	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
216597008678	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
216597008679	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
216597008680	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
216597008681	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
216597008682	hydrogenase assembly chaperone; Provisional; Region: PRK10409
216597008683	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
216597008684	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
216597008685	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
216597008686	dimerization interface [polypeptide binding]; other site
216597008687	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
216597008688	ATP binding site [chemical binding]; other site
216597008689	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
216597008690	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
216597008691	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
216597008692	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597008693	Walker A motif; other site
216597008694	ATP binding site [chemical binding]; other site
216597008695	Walker B motif; other site
216597008696	arginine finger; other site
216597008697	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216597008698	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
216597008699	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
216597008700	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
216597008701	metal binding site [ion binding]; metal-binding site
216597008702	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
216597008703	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
216597008704	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
216597008705	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216597008706	ABC-ATPase subunit  interface; other site
216597008707	dimer interface [polypeptide binding]; other site
216597008708	putative PBP binding regions; other site
216597008709	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
216597008710	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216597008711	ABC-ATPase subunit  interface; other site
216597008712	dimer interface [polypeptide binding]; other site
216597008713	putative PBP binding regions; other site
216597008714	effector protein YopJ; Provisional; Region: PRK15371
216597008715	transcriptional activator SprB; Provisional; Region: PRK15320
216597008716	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
216597008717	transcriptional regulator SirC; Provisional; Region: PRK15044
216597008718	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597008719	putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321
216597008720	invasion protein OrgB; Provisional; Region: PRK15322
216597008721	type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555
216597008722	invasion protein OrgA; Provisional; Region: PRK15323
216597008723	type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324
216597008724	type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325
216597008725	type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326
216597008726	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327
216597008727	Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480
216597008728	transcriptional regulator HilD; Provisional; Region: PRK15185
216597008729	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597008730	invasion protein regulator; Provisional; Region: PRK12370
216597008731	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597008732	DNA binding site [nucleotide binding]
216597008733	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216597008734	binding surface
216597008735	TPR motif; other site
216597008736	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
216597008737	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216597008738	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216597008739	catalytic residue [active]
216597008740	pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375
216597008741	SicP binding; Region: SicP-binding; pfam09119
216597008742	GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219
216597008743	switch II binding region; other site
216597008744	Rac1 P-loop interaction site [polypeptide binding]; other site
216597008745	GTP binding residues [chemical binding]; other site
216597008746	switch I binding region; other site
216597008747	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047
216597008748	active site
216597008749	chaperone protein SicP; Provisional; Region: PRK15329
216597008750	putative acyl carrier protein IacP; Validated; Region: PRK08172
216597008751	pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376
216597008752	cell invasion protein SipD; Provisional; Region: PRK15330
216597008753	pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373
216597008754	pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374
216597008755	chaperone protein SicA; Provisional; Region: PRK15331
216597008756	Tetratricopeptide repeat; Region: TPR_3; pfam07720
216597008757	Tetratricopeptide repeat; Region: TPR_3; pfam07720
216597008758	type III secretion system protein SpaS; Validated; Region: PRK08156
216597008759	type III secretion system protein SpaR; Provisional; Region: PRK15332
216597008760	type III secretion system protein SpaQ; Provisional; Region: PRK15333
216597008761	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
216597008762	type III secretion system protein SpaO; Validated; Region: PRK08158
216597008763	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
216597008764	antigen presentation protein SpaN; Provisional; Region: PRK15334
216597008765	Surface presentation of antigens protein; Region: SPAN; pfam02510
216597008766	Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090
216597008767	ATP synthase SpaL; Validated; Region: PRK08149
216597008768	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
216597008769	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216597008770	Walker A motif; other site
216597008771	ATP binding site [chemical binding]; other site
216597008772	Walker B motif; other site
216597008773	type III secretion system chaperone SpaK; Provisional; Region: PRK15336
216597008774	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
216597008775	type III secretion system protein InvA; Provisional; Region: PRK15337
216597008776	type III secretion system regulator InvE; Provisional; Region: PRK15338
216597008777	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
216597008778	type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339
216597008779	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216597008780	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216597008781	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
216597008782	transcriptional regulator InvF; Provisional; Region: PRK15340
216597008783	InvH outer membrane lipoprotein; Region: InvH; pfam04741
216597008784	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
216597008785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
216597008787	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
216597008788	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
216597008789	active site
216597008790	metal binding site [ion binding]; metal-binding site
216597008791	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
216597008792	MutS domain I; Region: MutS_I; pfam01624
216597008793	MutS domain II; Region: MutS_II; pfam05188
216597008794	MutS domain III; Region: MutS_III; pfam05192
216597008795	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
216597008796	Walker A/P-loop; other site
216597008797	ATP binding site [chemical binding]; other site
216597008798	Q-loop/lid; other site
216597008799	ABC transporter signature motif; other site
216597008800	Walker B; other site
216597008801	D-loop; other site
216597008802	H-loop/switch region; other site
216597008803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
216597008804	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597008805	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216597008806	putative substrate translocation pore; other site
216597008807	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597008808	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597008809	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216597008810	putative effector binding pocket; other site
216597008811	dimerization interface [polypeptide binding]; other site
216597008812	GntP family permease; Region: GntP_permease; pfam02447
216597008813	fructuronate transporter; Provisional; Region: PRK10034; cl15264
216597008814	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216597008815	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
216597008816	putative NAD(P) binding site [chemical binding]; other site
216597008817	active site
216597008818	putative substrate binding site [chemical binding]; other site
216597008819	hypothetical protein; Provisional; Region: PRK09989
216597008820	putative aldolase; Validated; Region: PRK08130
216597008821	intersubunit interface [polypeptide binding]; other site
216597008822	active site
216597008823	Zn2+ binding site [ion binding]; other site
216597008824	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
216597008825	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
216597008826	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
216597008827	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
216597008828	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
216597008829	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216597008830	MarR family; Region: MarR_2; cl17246
216597008831	Transcriptional regulators [Transcription]; Region: MarR; COG1846
216597008832	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
216597008833	Flavoprotein; Region: Flavoprotein; pfam02441
216597008834	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
216597008835	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
216597008836	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
216597008837	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216597008838	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
216597008839	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216597008840	DNA binding residues [nucleotide binding]
216597008841	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
216597008842	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216597008843	Peptidase family M23; Region: Peptidase_M23; pfam01551
216597008844	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
216597008845	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597008846	S-adenosylmethionine binding site [chemical binding]; other site
216597008847	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
216597008848	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
216597008849	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
216597008850	Permutation of conserved domain; other site
216597008851	active site
216597008852	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
216597008853	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
216597008854	homotrimer interaction site [polypeptide binding]; other site
216597008855	zinc binding site [ion binding]; other site
216597008856	CDP-binding sites; other site
216597008857	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
216597008858	substrate binding site; other site
216597008859	dimer interface; other site
216597008860	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
216597008861	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
216597008862	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
216597008863	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
216597008864	ligand-binding site [chemical binding]; other site
216597008865	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
216597008866	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
216597008867	CysD dimerization site [polypeptide binding]; other site
216597008868	G1 box; other site
216597008869	putative GEF interaction site [polypeptide binding]; other site
216597008870	GTP/Mg2+ binding site [chemical binding]; other site
216597008871	Switch I region; other site
216597008872	G2 box; other site
216597008873	G3 box; other site
216597008874	Switch II region; other site
216597008875	G4 box; other site
216597008876	G5 box; other site
216597008877	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
216597008878	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
216597008879	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
216597008880	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
216597008881	Active Sites [active]
216597008882	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
216597008883	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
216597008884	metal binding site [ion binding]; metal-binding site
216597008885	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
216597008886	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
216597008887	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
216597008888	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
216597008889	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
216597008890	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646
216597008891	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
216597008892	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669
216597008893	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
216597008894	CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203
216597008895	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
216597008896	pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379
216597008897	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
216597008898	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
216597008899	Active Sites [active]
216597008900	sulfite reductase subunit beta; Provisional; Region: PRK13504
216597008901	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
216597008902	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
216597008903	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
216597008904	Flavodoxin; Region: Flavodoxin_1; pfam00258
216597008905	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
216597008906	FAD binding pocket [chemical binding]; other site
216597008907	FAD binding motif [chemical binding]; other site
216597008908	catalytic residues [active]
216597008909	NAD binding pocket [chemical binding]; other site
216597008910	phosphate binding motif [ion binding]; other site
216597008911	beta-alpha-beta structure motif; other site
216597008912	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
216597008913	active site
216597008914	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
216597008915	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
216597008916	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
216597008917	enolase; Provisional; Region: eno; PRK00077
216597008918	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
216597008919	dimer interface [polypeptide binding]; other site
216597008920	metal binding site [ion binding]; metal-binding site
216597008921	substrate binding pocket [chemical binding]; other site
216597008922	CTP synthetase; Validated; Region: pyrG; PRK05380
216597008923	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
216597008924	Catalytic site [active]
216597008925	active site
216597008926	UTP binding site [chemical binding]; other site
216597008927	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
216597008928	active site
216597008929	putative oxyanion hole; other site
216597008930	catalytic triad [active]
216597008931	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
216597008932	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
216597008933	homodimer interface [polypeptide binding]; other site
216597008934	metal binding site [ion binding]; metal-binding site
216597008935	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
216597008936	homodimer interface [polypeptide binding]; other site
216597008937	active site
216597008938	putative chemical substrate binding site [chemical binding]; other site
216597008939	metal binding site [ion binding]; metal-binding site
216597008940	Fimbrial protein; Region: Fimbrial; cl01416
216597008941	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
216597008942	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
216597008943	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
216597008944	HD domain; Region: HD_4; pfam13328
216597008945	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
216597008946	synthetase active site [active]
216597008947	NTP binding site [chemical binding]; other site
216597008948	metal binding site [ion binding]; metal-binding site
216597008949	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
216597008950	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
216597008951	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
216597008952	TRAM domain; Region: TRAM; pfam01938
216597008953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597008954	S-adenosylmethionine binding site [chemical binding]; other site
216597008955	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
216597008956	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
216597008957	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597008958	dimerization interface [polypeptide binding]; other site
216597008959	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597008960	dimer interface [polypeptide binding]; other site
216597008961	phosphorylation site [posttranslational modification]
216597008962	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597008963	ATP binding site [chemical binding]; other site
216597008964	Mg2+ binding site [ion binding]; other site
216597008965	G-X-G motif; other site
216597008966	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
216597008967	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597008968	active site
216597008969	phosphorylation site [posttranslational modification]
216597008970	intermolecular recognition site; other site
216597008971	dimerization interface [polypeptide binding]; other site
216597008972	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216597008973	putative binding surface; other site
216597008974	active site
216597008975	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
216597008976	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
216597008977	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
216597008978	active site
216597008979	tetramer interface [polypeptide binding]; other site
216597008980	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
216597008981	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
216597008982	active site
216597008983	tetramer interface [polypeptide binding]; other site
216597008984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597008985	D-galactonate transporter; Region: 2A0114; TIGR00893
216597008986	putative substrate translocation pore; other site
216597008987	flavodoxin; Provisional; Region: PRK08105
216597008988	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
216597008989	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
216597008990	probable active site [active]
216597008991	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
216597008992	SecY interacting protein Syd; Provisional; Region: PRK04968
216597008993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
216597008994	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
216597008995	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
216597008996	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
216597008997	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
216597008998	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
216597008999	serine transporter; Region: stp; TIGR00814
216597009000	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
216597009001	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
216597009002	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
216597009003	flap endonuclease-like protein; Provisional; Region: PRK09482
216597009004	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
216597009005	active site
216597009006	metal binding site 1 [ion binding]; metal-binding site
216597009007	putative 5' ssDNA interaction site; other site
216597009008	metal binding site 3; metal-binding site
216597009009	metal binding site 2 [ion binding]; metal-binding site
216597009010	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
216597009011	putative DNA binding site [nucleotide binding]; other site
216597009012	putative metal binding site [ion binding]; other site
216597009013	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
216597009014	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
216597009015	dimer interface [polypeptide binding]; other site
216597009016	active site
216597009017	metal binding site [ion binding]; metal-binding site
216597009018	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
216597009019	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
216597009020	intersubunit interface [polypeptide binding]; other site
216597009021	active site
216597009022	Zn2+ binding site [ion binding]; other site
216597009023	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
216597009024	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597009025	putative substrate translocation pore; other site
216597009026	L-fucose isomerase; Provisional; Region: fucI; PRK10991
216597009027	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
216597009028	hexamer (dimer of trimers) interface [polypeptide binding]; other site
216597009029	trimer interface [polypeptide binding]; other site
216597009030	substrate binding site [chemical binding]; other site
216597009031	Mn binding site [ion binding]; other site
216597009032	L-fuculokinase; Provisional; Region: PRK10331
216597009033	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
216597009034	nucleotide binding site [chemical binding]; other site
216597009035	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
216597009036	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
216597009037	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
216597009038	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216597009039	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
216597009040	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
216597009041	hypothetical protein; Provisional; Region: PRK10873
216597009042	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216597009043	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597009044	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
216597009045	dimerization interface [polypeptide binding]; other site
216597009046	substrate binding pocket [chemical binding]; other site
216597009047	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
216597009048	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
216597009049	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
216597009050	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216597009051	catalytic residue [active]
216597009052	CsdA-binding activator; Provisional; Region: PRK15019
216597009053	Predicted permeases [General function prediction only]; Region: RarD; COG2962
216597009054	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
216597009055	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
216597009056	putative ATP binding site [chemical binding]; other site
216597009057	putative substrate interface [chemical binding]; other site
216597009058	murein transglycosylase A; Provisional; Region: mltA; PRK11162
216597009059	murein hydrolase B; Provisional; Region: PRK10760; cl17906
216597009060	MltA specific insert domain; Region: MltA; pfam03562
216597009061	3D domain; Region: 3D; pfam06725
216597009062	AMIN domain; Region: AMIN; pfam11741
216597009063	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
216597009064	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
216597009065	active site
216597009066	metal binding site [ion binding]; metal-binding site
216597009067	N-acetylglutamate synthase; Validated; Region: PRK05279
216597009068	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
216597009069	putative feedback inhibition sensing region; other site
216597009070	putative nucleotide binding site [chemical binding]; other site
216597009071	putative substrate binding site [chemical binding]; other site
216597009072	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597009073	Coenzyme A binding pocket [chemical binding]; other site
216597009074	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
216597009075	AAA domain; Region: AAA_30; pfam13604
216597009076	Family description; Region: UvrD_C_2; pfam13538
216597009077	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
216597009078	protease3; Provisional; Region: PRK15101
216597009079	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
216597009080	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
216597009081	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
216597009082	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
216597009083	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
216597009084	hypothetical protein; Provisional; Region: PRK10332
216597009085	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
216597009086	hypothetical protein; Provisional; Region: PRK11521
216597009087	hypothetical protein; Provisional; Region: PRK10557
216597009088	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
216597009089	hypothetical protein; Provisional; Region: PRK10506
216597009090	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
216597009091	thymidylate synthase; Reviewed; Region: thyA; PRK01827
216597009092	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
216597009093	dimerization interface [polypeptide binding]; other site
216597009094	active site
216597009095	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
216597009096	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
216597009097	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
216597009098	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
216597009099	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
216597009100	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
216597009101	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
216597009102	putative active site [active]
216597009103	Ap4A binding site [chemical binding]; other site
216597009104	nudix motif; other site
216597009105	putative metal binding site [ion binding]; other site
216597009106	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
216597009107	putative DNA-binding cleft [nucleotide binding]; other site
216597009108	putative DNA clevage site; other site
216597009109	molecular lever; other site
216597009110	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
216597009111	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
216597009112	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216597009113	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216597009114	active site
216597009115	catalytic tetrad [active]
216597009116	lysophospholipid transporter LplT; Provisional; Region: PRK11195
216597009117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597009118	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
216597009119	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
216597009120	putative acyl-acceptor binding pocket; other site
216597009121	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
216597009122	acyl-activating enzyme (AAE) consensus motif; other site
216597009123	putative AMP binding site [chemical binding]; other site
216597009124	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
216597009125	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597009126	DNA binding site [nucleotide binding]
216597009127	domain linker motif; other site
216597009128	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
216597009129	dimerization interface (closed form) [polypeptide binding]; other site
216597009130	ligand binding site [chemical binding]; other site
216597009131	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216597009132	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597009133	DNA binding site [nucleotide binding]
216597009134	domain linker motif; other site
216597009135	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
216597009136	dimerization interface (closed form) [polypeptide binding]; other site
216597009137	ligand binding site [chemical binding]; other site
216597009138	diaminopimelate decarboxylase; Provisional; Region: PRK11165
216597009139	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
216597009140	active site
216597009141	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216597009142	substrate binding site [chemical binding]; other site
216597009143	catalytic residues [active]
216597009144	dimer interface [polypeptide binding]; other site
216597009145	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
216597009146	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597009147	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216597009148	dimerization interface [polypeptide binding]; other site
216597009149	putative racemase; Provisional; Region: PRK10200
216597009150	aspartate racemase; Region: asp_race; TIGR00035
216597009151	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
216597009152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597009153	putative substrate translocation pore; other site
216597009154	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597009155	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
216597009156	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
216597009157	NADP binding site [chemical binding]; other site
216597009158	homodimer interface [polypeptide binding]; other site
216597009159	active site
216597009160	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
216597009161	putative acyltransferase; Provisional; Region: PRK05790
216597009162	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
216597009163	dimer interface [polypeptide binding]; other site
216597009164	active site
216597009165	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597009166	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597009167	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216597009168	dimerization interface [polypeptide binding]; other site
216597009169	Predicted membrane protein [Function unknown]; Region: COG4125
216597009170	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
216597009171	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
216597009172	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
216597009173	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
216597009174	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
216597009175	putative metal binding site [ion binding]; other site
216597009176	putative homodimer interface [polypeptide binding]; other site
216597009177	putative homotetramer interface [polypeptide binding]; other site
216597009178	putative homodimer-homodimer interface [polypeptide binding]; other site
216597009179	putative allosteric switch controlling residues; other site
216597009180	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
216597009181	transcriptional activator SprB; Provisional; Region: PRK15320
216597009182	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600
216597009183	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
216597009184	Fimbrial protein; Region: Fimbrial; pfam00419
216597009185	fimbrial chaperone protein StdC; Provisional; Region: PRK15254
216597009186	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597009187	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597009188	fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255
216597009189	PapC N-terminal domain; Region: PapC_N; pfam13954
216597009190	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216597009191	PapC C-terminal domain; Region: PapC_C; pfam13953
216597009192	fimbrial protein StdA; Provisional; Region: PRK15210
216597009193	hypothetical protein; Provisional; Region: PRK10316
216597009194	YfdX protein; Region: YfdX; pfam10938
216597009195	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
216597009196	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
216597009197	oligomeric interface; other site
216597009198	putative active site [active]
216597009199	homodimer interface [polypeptide binding]; other site
216597009200	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
216597009201	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
216597009202	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216597009203	Peptidase family M23; Region: Peptidase_M23; pfam01551
216597009204	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
216597009205	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
216597009206	active site
216597009207	metal binding site [ion binding]; metal-binding site
216597009208	nudix motif; other site
216597009209	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
216597009210	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
216597009211	dimer interface [polypeptide binding]; other site
216597009212	putative anticodon binding site; other site
216597009213	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
216597009214	motif 1; other site
216597009215	active site
216597009216	motif 2; other site
216597009217	motif 3; other site
216597009218	This domain is found in peptide chain release factors; Region: PCRF; smart00937
216597009219	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
216597009220	RF-1 domain; Region: RF-1; pfam00472
216597009221	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
216597009222	DHH family; Region: DHH; pfam01368
216597009223	DHHA1 domain; Region: DHHA1; pfam02272
216597009224	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
216597009225	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
216597009226	dimerization domain [polypeptide binding]; other site
216597009227	dimer interface [polypeptide binding]; other site
216597009228	catalytic residues [active]
216597009229	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
216597009230	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
216597009231	active site
216597009232	Int/Topo IB signature motif; other site
216597009233	flavodoxin FldB; Provisional; Region: PRK12359
216597009234	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
216597009235	hypothetical protein; Provisional; Region: PRK10878
216597009236	putative global regulator; Reviewed; Region: PRK09559
216597009237	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
216597009238	hemolysin; Provisional; Region: PRK15087
216597009239	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
216597009240	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
216597009241	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
216597009242	beta-galactosidase; Region: BGL; TIGR03356
216597009243	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
216597009244	glycine dehydrogenase; Provisional; Region: PRK05367
216597009245	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
216597009246	tetramer interface [polypeptide binding]; other site
216597009247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597009248	catalytic residue [active]
216597009249	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
216597009250	tetramer interface [polypeptide binding]; other site
216597009251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597009252	catalytic residue [active]
216597009253	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
216597009254	lipoyl attachment site [posttranslational modification]; other site
216597009255	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
216597009256	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
216597009257	oxidoreductase; Provisional; Region: PRK08013
216597009258	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
216597009259	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
216597009260	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
216597009261	proline aminopeptidase P II; Provisional; Region: PRK10879
216597009262	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
216597009263	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
216597009264	active site
216597009265	hypothetical protein; Reviewed; Region: PRK01736
216597009266	Z-ring-associated protein; Provisional; Region: PRK10972
216597009267	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
216597009268	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
216597009269	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
216597009270	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
216597009271	ligand binding site [chemical binding]; other site
216597009272	NAD binding site [chemical binding]; other site
216597009273	tetramer interface [polypeptide binding]; other site
216597009274	catalytic site [active]
216597009275	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
216597009276	L-serine binding site [chemical binding]; other site
216597009277	ACT domain interface; other site
216597009278	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
216597009279	tetramer (dimer of dimers) interface [polypeptide binding]; other site
216597009280	active site
216597009281	dimer interface [polypeptide binding]; other site
216597009282	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
216597009283	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597009284	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
216597009285	putative dimerization interface [polypeptide binding]; other site
216597009286	Uncharacterized conserved protein [Function unknown]; Region: COG2968
216597009287	oxidative stress defense protein; Provisional; Region: PRK11087
216597009288	arginine exporter protein; Provisional; Region: PRK09304
216597009289	mechanosensitive channel MscS; Provisional; Region: PRK10334
216597009290	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216597009291	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
216597009292	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
216597009293	active site
216597009294	intersubunit interface [polypeptide binding]; other site
216597009295	zinc binding site [ion binding]; other site
216597009296	Na+ binding site [ion binding]; other site
216597009297	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
216597009298	Phosphoglycerate kinase; Region: PGK; pfam00162
216597009299	substrate binding site [chemical binding]; other site
216597009300	hinge regions; other site
216597009301	ADP binding site [chemical binding]; other site
216597009302	catalytic site [active]
216597009303	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
216597009304	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
216597009305	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
216597009306	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
216597009307	trimer interface [polypeptide binding]; other site
216597009308	putative Zn binding site [ion binding]; other site
216597009309	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
216597009310	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
216597009311	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
216597009312	Walker A/P-loop; other site
216597009313	ATP binding site [chemical binding]; other site
216597009314	Q-loop/lid; other site
216597009315	ABC transporter signature motif; other site
216597009316	Walker B; other site
216597009317	D-loop; other site
216597009318	H-loop/switch region; other site
216597009319	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
216597009320	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
216597009321	Walker A/P-loop; other site
216597009322	ATP binding site [chemical binding]; other site
216597009323	Q-loop/lid; other site
216597009324	ABC transporter signature motif; other site
216597009325	Walker B; other site
216597009326	D-loop; other site
216597009327	H-loop/switch region; other site
216597009328	transketolase; Reviewed; Region: PRK12753
216597009329	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
216597009330	TPP-binding site [chemical binding]; other site
216597009331	dimer interface [polypeptide binding]; other site
216597009332	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
216597009333	PYR/PP interface [polypeptide binding]; other site
216597009334	dimer interface [polypeptide binding]; other site
216597009335	TPP binding site [chemical binding]; other site
216597009336	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
216597009337	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
216597009338	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
216597009339	agmatinase; Region: agmatinase; TIGR01230
216597009340	oligomer interface [polypeptide binding]; other site
216597009341	putative active site [active]
216597009342	Mn binding site [ion binding]; other site
216597009343	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216597009344	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
216597009345	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
216597009346	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
216597009347	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
216597009348	putative NAD(P) binding site [chemical binding]; other site
216597009349	catalytic Zn binding site [ion binding]; other site
216597009350	structural Zn binding site [ion binding]; other site
216597009351	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
216597009352	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
216597009353	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
216597009354	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216597009355	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597009356	DNA-binding site [nucleotide binding]; DNA binding site
216597009357	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216597009358	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
216597009359	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
216597009360	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
216597009361	dimer interface [polypeptide binding]; other site
216597009362	active site
216597009363	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216597009364	catalytic residues [active]
216597009365	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
216597009366	Virulence promoting factor; Region: YqgB; pfam11036
216597009367	Protein of unknown function (DUF2684); Region: DUF2684; pfam10885
216597009368	S-adenosylmethionine synthetase; Validated; Region: PRK05250
216597009369	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
216597009370	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
216597009371	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
216597009372	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
216597009373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597009374	putative substrate translocation pore; other site
216597009375	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597009376	hypothetical protein; Provisional; Region: PRK04860
216597009377	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
216597009378	DNA-specific endonuclease I; Provisional; Region: PRK15137
216597009379	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
216597009380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
216597009381	RNA methyltransferase, RsmE family; Region: TIGR00046
216597009382	glutathione synthetase; Provisional; Region: PRK05246
216597009383	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
216597009384	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
216597009385	hypothetical protein; Validated; Region: PRK00228
216597009386	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
216597009387	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
216597009388	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216597009389	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
216597009390	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
216597009391	Walker A motif; other site
216597009392	ATP binding site [chemical binding]; other site
216597009393	Walker B motif; other site
216597009394	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
216597009395	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216597009396	catalytic residue [active]
216597009397	YGGT family; Region: YGGT; pfam02325
216597009398	YGGT family; Region: YGGT; pfam02325
216597009399	hypothetical protein; Validated; Region: PRK05090
216597009400	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
216597009401	active site
216597009402	dimerization interface [polypeptide binding]; other site
216597009403	HemN family oxidoreductase; Provisional; Region: PRK05660
216597009404	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597009405	FeS/SAM binding site; other site
216597009406	HemN C-terminal domain; Region: HemN_C; pfam06969
216597009407	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
216597009408	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
216597009409	homodimer interface [polypeptide binding]; other site
216597009410	active site
216597009411	hypothetical protein; Provisional; Region: PRK10626
216597009412	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
216597009413	hypothetical protein; Provisional; Region: PRK11702
216597009414	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
216597009415	adenine DNA glycosylase; Provisional; Region: PRK10880
216597009416	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
216597009417	minor groove reading motif; other site
216597009418	helix-hairpin-helix signature motif; other site
216597009419	substrate binding pocket [chemical binding]; other site
216597009420	active site
216597009421	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
216597009422	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
216597009423	DNA binding and oxoG recognition site [nucleotide binding]
216597009424	oxidative damage protection protein; Provisional; Region: PRK05408
216597009425	murein transglycosylase C; Provisional; Region: mltC; PRK11671
216597009426	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
216597009427	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216597009428	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216597009429	catalytic residue [active]
216597009430	nucleoside transporter; Region: 2A0110; TIGR00889
216597009431	ornithine decarboxylase; Provisional; Region: PRK13578
216597009432	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
216597009433	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
216597009434	homodimer interface [polypeptide binding]; other site
216597009435	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597009436	catalytic residue [active]
216597009437	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
216597009438	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
216597009439	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
216597009440	dimer interface [polypeptide binding]; other site
216597009441	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216597009442	metal binding site [ion binding]; metal-binding site
216597009443	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
216597009444	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
216597009445	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
216597009446	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
216597009447	putative active site [active]
216597009448	putative catalytic site [active]
216597009449	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
216597009450	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
216597009451	putative dimerization interface [polypeptide binding]; other site
216597009452	putative substrate binding pocket [chemical binding]; other site
216597009453	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
216597009454	Sulfatase; Region: Sulfatase; pfam00884
216597009455	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
216597009456	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597009457	FeS/SAM binding site; other site
216597009458	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
216597009459	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216597009460	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597009461	DNA binding residues [nucleotide binding]
216597009462	dimerization interface [polypeptide binding]; other site
216597009463	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
216597009464	Amino acid permease; Region: AA_permease_2; pfam13520
216597009465	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
216597009466	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216597009467	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216597009468	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
216597009469	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216597009470	NAD(P) binding site [chemical binding]; other site
216597009471	catalytic residues [active]
216597009472	DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128
216597009473	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
216597009474	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
216597009475	active site
216597009476	catalytic site [active]
216597009477	Zn binding site [ion binding]; other site
216597009478	tetramer interface [polypeptide binding]; other site
216597009479	Predicted amidohydrolase [General function prediction only]; Region: COG0388
216597009480	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
216597009481	putative active site [active]
216597009482	catalytic triad [active]
216597009483	putative dimer interface [polypeptide binding]; other site
216597009484	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597009485	D-galactonate transporter; Region: 2A0114; TIGR00893
216597009486	putative substrate translocation pore; other site
216597009487	mannonate dehydratase; Provisional; Region: PRK03906
216597009488	mannonate dehydratase; Region: uxuA; TIGR00695
216597009489	D-mannonate oxidoreductase; Provisional; Region: PRK15037
216597009490	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
216597009491	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
216597009492	Glucuronate isomerase; Region: UxaC; pfam02614
216597009493	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
216597009494	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216597009495	dimer interface [polypeptide binding]; other site
216597009496	putative CheW interface [polypeptide binding]; other site
216597009497	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
216597009498	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
216597009499	CHAP domain; Region: CHAP; pfam05257
216597009500	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
216597009501	putative S-transferase; Provisional; Region: PRK11752
216597009502	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
216597009503	C-terminal domain interface [polypeptide binding]; other site
216597009504	GSH binding site (G-site) [chemical binding]; other site
216597009505	dimer interface [polypeptide binding]; other site
216597009506	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
216597009507	dimer interface [polypeptide binding]; other site
216597009508	N-terminal domain interface [polypeptide binding]; other site
216597009509	active site
216597009510	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
216597009511	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
216597009512	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
216597009513	putative ligand binding residues [chemical binding]; other site
216597009514	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
216597009515	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
216597009516	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
216597009517	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
216597009518	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
216597009519	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
216597009520	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
216597009521	putative substrate-binding site; other site
216597009522	nickel binding site [ion binding]; other site
216597009523	hydrogenase 2 large subunit; Provisional; Region: PRK10467
216597009524	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
216597009525	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
216597009526	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
216597009527	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
216597009528	4Fe-4S binding domain; Region: Fer4_6; pfam12837
216597009529	hydrogenase 2 small subunit; Provisional; Region: PRK10468
216597009530	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
216597009531	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
216597009532	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
216597009533	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
216597009534	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597009535	dimerization interface [polypeptide binding]; other site
216597009536	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216597009537	dimer interface [polypeptide binding]; other site
216597009538	putative CheW interface [polypeptide binding]; other site
216597009539	hypothetical protein; Provisional; Region: PRK05208
216597009540	oxidoreductase; Provisional; Region: PRK07985
216597009541	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
216597009542	NAD binding site [chemical binding]; other site
216597009543	metal binding site [ion binding]; metal-binding site
216597009544	active site
216597009545	biopolymer transport protein ExbD; Provisional; Region: PRK11267
216597009546	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
216597009547	biopolymer transport protein ExbB; Provisional; Region: PRK10414
216597009548	cystathionine beta-lyase; Provisional; Region: PRK08114
216597009549	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
216597009550	homodimer interface [polypeptide binding]; other site
216597009551	substrate-cofactor binding pocket; other site
216597009552	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597009553	catalytic residue [active]
216597009554	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
216597009555	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
216597009556	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
216597009557	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216597009558	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597009559	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597009560	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
216597009561	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
216597009562	dimer interface [polypeptide binding]; other site
216597009563	active site
216597009564	metal binding site [ion binding]; metal-binding site
216597009565	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216597009566	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216597009567	active site
216597009568	catalytic tetrad [active]
216597009569	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
216597009570	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
216597009571	transmembrane helices; other site
216597009572	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
216597009573	nucleotide binding site/active site [active]
216597009574	catalytic residue [active]
216597009575	hypothetical protein; Provisional; Region: PRK01254
216597009576	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
216597009577	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
216597009578	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
216597009579	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
216597009580	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
216597009581	DctM-like transporters; Region: DctM; pfam06808
216597009582	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
216597009583	FtsI repressor; Provisional; Region: PRK10883
216597009584	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
216597009585	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
216597009586	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
216597009587	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
216597009588	putative acyl-acceptor binding pocket; other site
216597009589	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
216597009590	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
216597009591	CAP-like domain; other site
216597009592	active site
216597009593	primary dimer interface [polypeptide binding]; other site
216597009594	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216597009595	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216597009596	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597009597	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
216597009598	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
216597009599	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
216597009600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597009601	active site
216597009602	phosphorylation site [posttranslational modification]
216597009603	intermolecular recognition site; other site
216597009604	dimerization interface [polypeptide binding]; other site
216597009605	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597009606	DNA binding site [nucleotide binding]
216597009607	sensor protein QseC; Provisional; Region: PRK10337
216597009608	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
216597009609	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597009610	dimer interface [polypeptide binding]; other site
216597009611	phosphorylation site [posttranslational modification]
216597009612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597009613	ATP binding site [chemical binding]; other site
216597009614	Mg2+ binding site [ion binding]; other site
216597009615	G-X-G motif; other site
216597009616	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
216597009617	Uncharacterized conserved protein [Function unknown]; Region: COG1359
216597009618	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
216597009619	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597009620	ATP binding site [chemical binding]; other site
216597009621	Mg2+ binding site [ion binding]; other site
216597009622	G-X-G motif; other site
216597009623	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
216597009624	anchoring element; other site
216597009625	dimer interface [polypeptide binding]; other site
216597009626	ATP binding site [chemical binding]; other site
216597009627	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
216597009628	active site
216597009629	metal binding site [ion binding]; metal-binding site
216597009630	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
216597009631	esterase YqiA; Provisional; Region: PRK11071
216597009632	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
216597009633	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
216597009634	active site
216597009635	metal binding site [ion binding]; metal-binding site
216597009636	hexamer interface [polypeptide binding]; other site
216597009637	putative dehydrogenase; Provisional; Region: PRK11039
216597009638	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
216597009639	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
216597009640	dimer interface [polypeptide binding]; other site
216597009641	ADP-ribose binding site [chemical binding]; other site
216597009642	active site
216597009643	nudix motif; other site
216597009644	metal binding site [ion binding]; metal-binding site
216597009645	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
216597009646	hypothetical protein; Provisional; Region: PRK11653
216597009647	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
216597009648	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
216597009649	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
216597009650	putative active site [active]
216597009651	metal binding site [ion binding]; metal-binding site
216597009652	zinc transporter ZupT; Provisional; Region: PRK04201
216597009653	ZIP Zinc transporter; Region: Zip; pfam02535
216597009654	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
216597009655	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
216597009656	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
216597009657	catalytic residues [active]
216597009658	hinge region; other site
216597009659	alpha helical domain; other site
216597009660	putative disulfide oxidoreductase; Provisional; Region: PRK04307
216597009661	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
216597009662	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
216597009663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
216597009664	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
216597009665	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
216597009666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
216597009667	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
216597009668	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
216597009669	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
216597009670	putative ribose interaction site [chemical binding]; other site
216597009671	putative ADP binding site [chemical binding]; other site
216597009672	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
216597009673	active site
216597009674	nucleotide binding site [chemical binding]; other site
216597009675	HIGH motif; other site
216597009676	KMSKS motif; other site
216597009677	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
216597009678	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
216597009679	metal binding triad; other site
216597009680	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
216597009681	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
216597009682	metal binding triad; other site
216597009683	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
216597009684	Uncharacterized conserved protein [Function unknown]; Region: COG3025
216597009685	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
216597009686	putative active site [active]
216597009687	putative metal binding residues [ion binding]; other site
216597009688	signature motif; other site
216597009689	putative triphosphate binding site [ion binding]; other site
216597009690	CHAD domain; Region: CHAD; pfam05235
216597009691	SH3 domain-containing protein; Provisional; Region: PRK10884
216597009692	Bacterial SH3 domain homologues; Region: SH3b; smart00287
216597009693	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
216597009694	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
216597009695	active site
216597009696	NTP binding site [chemical binding]; other site
216597009697	metal binding triad [ion binding]; metal-binding site
216597009698	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
216597009699	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216597009700	Zn2+ binding site [ion binding]; other site
216597009701	Mg2+ binding site [ion binding]; other site
216597009702	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
216597009703	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
216597009704	homooctamer interface [polypeptide binding]; other site
216597009705	active site
216597009706	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
216597009707	UGMP family protein; Validated; Region: PRK09604
216597009708	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
216597009709	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
216597009710	DNA primase; Validated; Region: dnaG; PRK05667
216597009711	CHC2 zinc finger; Region: zf-CHC2; pfam01807
216597009712	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
216597009713	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
216597009714	active site
216597009715	metal binding site [ion binding]; metal-binding site
216597009716	interdomain interaction site; other site
216597009717	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
216597009718	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
216597009719	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
216597009720	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
216597009721	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
216597009722	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
216597009723	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216597009724	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
216597009725	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216597009726	DNA binding residues [nucleotide binding]
216597009727	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
216597009728	active site
216597009729	SUMO-1 interface [polypeptide binding]; other site
216597009730	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
216597009731	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
216597009732	FAD binding pocket [chemical binding]; other site
216597009733	FAD binding motif [chemical binding]; other site
216597009734	phosphate binding motif [ion binding]; other site
216597009735	NAD binding pocket [chemical binding]; other site
216597009736	Predicted transcriptional regulators [Transcription]; Region: COG1695
216597009737	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
216597009738	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216597009739	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597009740	dimerization interface [polypeptide binding]; other site
216597009741	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216597009742	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216597009743	dimer interface [polypeptide binding]; other site
216597009744	putative CheW interface [polypeptide binding]; other site
216597009745	PAS fold; Region: PAS_3; pfam08447
216597009746	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216597009747	putative active site [active]
216597009748	heme pocket [chemical binding]; other site
216597009749	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216597009750	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216597009751	dimer interface [polypeptide binding]; other site
216597009752	putative CheW interface [polypeptide binding]; other site
216597009753	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
216597009754	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216597009755	inhibitor-cofactor binding pocket; inhibition site
216597009756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597009757	catalytic residue [active]
216597009758	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216597009759	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
216597009760	active site
216597009761	FMN binding site [chemical binding]; other site
216597009762	2,4-decadienoyl-CoA binding site; other site
216597009763	catalytic residue [active]
216597009764	4Fe-4S cluster binding site [ion binding]; other site
216597009765	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
216597009766	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216597009767	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
216597009768	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597009769	S-adenosylmethionine binding site [chemical binding]; other site
216597009770	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
216597009771	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
216597009772	putative active site [active]
216597009773	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
216597009774	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216597009775	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
216597009776	serine/threonine transporter SstT; Provisional; Region: PRK13628
216597009777	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216597009778	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
216597009779	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
216597009780	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
216597009781	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
216597009782	Predicted membrane protein [Function unknown]; Region: COG5393
216597009783	YqjK-like protein; Region: YqjK; pfam13997
216597009784	Predicted membrane protein [Function unknown]; Region: COG2259
216597009785	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
216597009786	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
216597009787	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
216597009788	putative dimer interface [polypeptide binding]; other site
216597009789	N-terminal domain interface [polypeptide binding]; other site
216597009790	putative substrate binding pocket (H-site) [chemical binding]; other site
216597009791	Predicted membrane protein [Function unknown]; Region: COG3152
216597009792	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597009793	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
216597009794	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216597009795	dimerization interface [polypeptide binding]; other site
216597009796	Pirin-related protein [General function prediction only]; Region: COG1741
216597009797	Pirin; Region: Pirin; pfam02678
216597009798	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
216597009799	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
216597009800	serine transporter; Region: stp; TIGR00814
216597009801	L-serine dehydratase TdcG; Provisional; Region: PRK15040
216597009802	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
216597009803	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
216597009804	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
216597009805	Pyruvate formate lyase 1; Region: PFL1; cd01678
216597009806	coenzyme A binding site [chemical binding]; other site
216597009807	active site
216597009808	catalytic residues [active]
216597009809	glycine loop; other site
216597009810	propionate/acetate kinase; Provisional; Region: PRK12379
216597009811	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
216597009812	threonine/serine transporter TdcC; Provisional; Region: PRK13629
216597009813	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
216597009814	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
216597009815	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
216597009816	tetramer interface [polypeptide binding]; other site
216597009817	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597009818	catalytic residue [active]
216597009819	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
216597009820	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597009821	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
216597009822	putative substrate binding pocket [chemical binding]; other site
216597009823	putative dimerization interface [polypeptide binding]; other site
216597009824	glycerate kinase I; Provisional; Region: PRK10342
216597009825	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
216597009826	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
216597009827	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
216597009828	galactarate dehydratase; Region: galactar-dH20; TIGR03248
216597009829	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
216597009830	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
216597009831	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216597009832	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
216597009833	substrate binding site [chemical binding]; other site
216597009834	ATP binding site [chemical binding]; other site
216597009835	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
216597009836	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
216597009837	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216597009838	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
216597009839	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
216597009840	intersubunit interface [polypeptide binding]; other site
216597009841	active site
216597009842	zinc binding site [ion binding]; other site
216597009843	Na+ binding site [ion binding]; other site
216597009844	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
216597009845	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
216597009846	putative substrate binding site [chemical binding]; other site
216597009847	putative ATP binding site [chemical binding]; other site
216597009848	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
216597009849	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
216597009850	active site
216597009851	P-loop; other site
216597009852	phosphorylation site [posttranslational modification]
216597009853	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
216597009854	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216597009855	active site
216597009856	phosphorylation site [posttranslational modification]
216597009857	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
216597009858	dimerization domain swap beta strand [polypeptide binding]; other site
216597009859	regulatory protein interface [polypeptide binding]; other site
216597009860	active site
216597009861	regulatory phosphorylation site [posttranslational modification]; other site
216597009862	D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052
216597009863	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216597009864	active site
216597009865	phosphorylation site [posttranslational modification]
216597009866	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
216597009867	active site
216597009868	P-loop; other site
216597009869	phosphorylation site [posttranslational modification]
216597009870	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
216597009871	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
216597009872	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
216597009873	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
216597009874	putative NAD(P) binding site [chemical binding]; other site
216597009875	catalytic Zn binding site [ion binding]; other site
216597009876	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
216597009877	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
216597009878	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216597009879	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
216597009880	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
216597009881	putative SAM binding site [chemical binding]; other site
216597009882	putative homodimer interface [polypeptide binding]; other site
216597009883	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
216597009884	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
216597009885	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
216597009886	putative ligand binding site [chemical binding]; other site
216597009887	TIGR00252 family protein; Region: TIGR00252
216597009888	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
216597009889	dimer interface [polypeptide binding]; other site
216597009890	active site
216597009891	outer membrane lipoprotein; Provisional; Region: PRK11023
216597009892	BON domain; Region: BON; pfam04972
216597009893	BON domain; Region: BON; pfam04972
216597009894	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
216597009895	NADH(P)-binding; Region: NAD_binding_10; pfam13460
216597009896	NAD binding site [chemical binding]; other site
216597009897	active site
216597009898	intracellular protease, PfpI family; Region: PfpI; TIGR01382
216597009899	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
216597009900	proposed catalytic triad [active]
216597009901	conserved cys residue [active]
216597009902	hypothetical protein; Provisional; Region: PRK03467
216597009903	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
216597009904	GIY-YIG motif/motif A; other site
216597009905	putative active site [active]
216597009906	putative metal binding site [ion binding]; other site
216597009907	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
216597009908	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597009909	Coenzyme A binding pocket [chemical binding]; other site
216597009910	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
216597009911	Peptidase family U32; Region: Peptidase_U32; pfam01136
216597009912	putative protease; Provisional; Region: PRK15447
216597009913	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
216597009914	hypothetical protein; Provisional; Region: PRK10508
216597009915	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
216597009916	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
216597009917	tryptophan permease; Provisional; Region: PRK10483
216597009918	aromatic amino acid transport protein; Region: araaP; TIGR00837
216597009919	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
216597009920	DEAD-like helicases superfamily; Region: DEXDc; smart00487
216597009921	ATP binding site [chemical binding]; other site
216597009922	Mg++ binding site [ion binding]; other site
216597009923	motif III; other site
216597009924	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597009925	nucleotide binding region [chemical binding]; other site
216597009926	ATP-binding site [chemical binding]; other site
216597009927	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
216597009928	putative RNA binding site [nucleotide binding]; other site
216597009929	lipoprotein NlpI; Provisional; Region: PRK11189
216597009930	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216597009931	binding surface
216597009932	TPR motif; other site
216597009933	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
216597009934	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
216597009935	RNase E interface [polypeptide binding]; other site
216597009936	trimer interface [polypeptide binding]; other site
216597009937	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
216597009938	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
216597009939	RNase E interface [polypeptide binding]; other site
216597009940	trimer interface [polypeptide binding]; other site
216597009941	active site
216597009942	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
216597009943	putative nucleic acid binding region [nucleotide binding]; other site
216597009944	G-X-X-G motif; other site
216597009945	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
216597009946	RNA binding site [nucleotide binding]; other site
216597009947	domain interface; other site
216597009948	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
216597009949	16S/18S rRNA binding site [nucleotide binding]; other site
216597009950	S13e-L30e interaction site [polypeptide binding]; other site
216597009951	25S rRNA binding site [nucleotide binding]; other site
216597009952	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
216597009953	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
216597009954	RNA binding site [nucleotide binding]; other site
216597009955	active site
216597009956	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
216597009957	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
216597009958	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
216597009959	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
216597009960	translation initiation factor IF-2; Region: IF-2; TIGR00487
216597009961	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
216597009962	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
216597009963	G1 box; other site
216597009964	putative GEF interaction site [polypeptide binding]; other site
216597009965	GTP/Mg2+ binding site [chemical binding]; other site
216597009966	Switch I region; other site
216597009967	G2 box; other site
216597009968	G3 box; other site
216597009969	Switch II region; other site
216597009970	G4 box; other site
216597009971	G5 box; other site
216597009972	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
216597009973	Translation-initiation factor 2; Region: IF-2; pfam11987
216597009974	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
216597009975	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
216597009976	NusA N-terminal domain; Region: NusA_N; pfam08529
216597009977	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
216597009978	RNA binding site [nucleotide binding]; other site
216597009979	homodimer interface [polypeptide binding]; other site
216597009980	NusA-like KH domain; Region: KH_5; pfam13184
216597009981	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
216597009982	G-X-X-G motif; other site
216597009983	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
216597009984	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
216597009985	ribosome maturation protein RimP; Reviewed; Region: PRK00092
216597009986	hypothetical protein; Provisional; Region: PRK14641
216597009987	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
216597009988	putative oligomer interface [polypeptide binding]; other site
216597009989	putative RNA binding site [nucleotide binding]; other site
216597009990	argininosuccinate synthase; Validated; Region: PRK05370
216597009991	argininosuccinate synthase; Provisional; Region: PRK13820
216597009992	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
216597009993	Preprotein translocase SecG subunit; Region: SecG; pfam03840
216597009994	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
216597009995	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
216597009996	active site
216597009997	substrate binding site [chemical binding]; other site
216597009998	metal binding site [ion binding]; metal-binding site
216597009999	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
216597010000	dihydropteroate synthase; Region: DHPS; TIGR01496
216597010001	substrate binding pocket [chemical binding]; other site
216597010002	dimer interface [polypeptide binding]; other site
216597010003	inhibitor binding site; inhibition site
216597010004	Transposase IS200 like; Region: Y1_Tnp; pfam01797
216597010005	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
216597010006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597010007	Walker A motif; other site
216597010008	ATP binding site [chemical binding]; other site
216597010009	Walker B motif; other site
216597010010	arginine finger; other site
216597010011	Peptidase family M41; Region: Peptidase_M41; pfam01434
216597010012	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
216597010013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597010014	S-adenosylmethionine binding site [chemical binding]; other site
216597010015	RNA-binding protein YhbY; Provisional; Region: PRK10343
216597010016	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
216597010017	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
216597010018	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
216597010019	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
216597010020	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
216597010021	GTPase CgtA; Reviewed; Region: obgE; PRK12298
216597010022	GTP1/OBG; Region: GTP1_OBG; pfam01018
216597010023	Obg GTPase; Region: Obg; cd01898
216597010024	G1 box; other site
216597010025	GTP/Mg2+ binding site [chemical binding]; other site
216597010026	Switch I region; other site
216597010027	G2 box; other site
216597010028	G3 box; other site
216597010029	Switch II region; other site
216597010030	G4 box; other site
216597010031	G5 box; other site
216597010032	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216597010033	EamA-like transporter family; Region: EamA; pfam00892
216597010034	EamA-like transporter family; Region: EamA; pfam00892
216597010035	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
216597010036	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
216597010037	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
216597010038	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
216597010039	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
216597010040	substrate binding pocket [chemical binding]; other site
216597010041	chain length determination region; other site
216597010042	substrate-Mg2+ binding site; other site
216597010043	catalytic residues [active]
216597010044	aspartate-rich region 1; other site
216597010045	active site lid residues [active]
216597010046	aspartate-rich region 2; other site
216597010047	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
216597010048	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
216597010049	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
216597010050	hinge; other site
216597010051	active site
216597010052	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
216597010053	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
216597010054	anti sigma factor interaction site; other site
216597010055	regulatory phosphorylation site [posttranslational modification]; other site
216597010056	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
216597010057	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
216597010058	mce related protein; Region: MCE; pfam02470
216597010059	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
216597010060	conserved hypothetical integral membrane protein; Region: TIGR00056
216597010061	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
216597010062	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
216597010063	Walker A/P-loop; other site
216597010064	ATP binding site [chemical binding]; other site
216597010065	Q-loop/lid; other site
216597010066	ABC transporter signature motif; other site
216597010067	Walker B; other site
216597010068	D-loop; other site
216597010069	H-loop/switch region; other site
216597010070	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
216597010071	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
216597010072	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
216597010073	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
216597010074	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
216597010075	putative active site [active]
216597010076	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
216597010077	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
216597010078	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
216597010079	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
216597010080	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
216597010081	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
216597010082	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
216597010083	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
216597010084	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
216597010085	Walker A/P-loop; other site
216597010086	ATP binding site [chemical binding]; other site
216597010087	Q-loop/lid; other site
216597010088	ABC transporter signature motif; other site
216597010089	Walker B; other site
216597010090	D-loop; other site
216597010091	H-loop/switch region; other site
216597010092	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
216597010093	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
216597010094	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
216597010095	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
216597010096	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
216597010097	30S subunit binding site; other site
216597010098	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216597010099	active site
216597010100	phosphorylation site [posttranslational modification]
216597010101	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
216597010102	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
216597010103	dimerization domain swap beta strand [polypeptide binding]; other site
216597010104	regulatory protein interface [polypeptide binding]; other site
216597010105	active site
216597010106	regulatory phosphorylation site [posttranslational modification]; other site
216597010107	hypothetical protein; Provisional; Region: PRK10345
216597010108	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
216597010109	Transglycosylase; Region: Transgly; cl17702
216597010110	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
216597010111	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
216597010112	conserved cys residue [active]
216597010113	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
216597010114	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216597010115	putative active site [active]
216597010116	heme pocket [chemical binding]; other site
216597010117	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597010118	dimer interface [polypeptide binding]; other site
216597010119	phosphorylation site [posttranslational modification]
216597010120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597010121	ATP binding site [chemical binding]; other site
216597010122	Mg2+ binding site [ion binding]; other site
216597010123	G-X-G motif; other site
216597010124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597010125	active site
216597010126	phosphorylation site [posttranslational modification]
216597010127	intermolecular recognition site; other site
216597010128	dimerization interface [polypeptide binding]; other site
216597010129	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216597010130	putative binding surface; other site
216597010131	active site
216597010132	radical SAM protein, TIGR01212 family; Region: TIGR01212
216597010133	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597010134	FeS/SAM binding site; other site
216597010135	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
216597010136	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
216597010137	active site
216597010138	dimer interface [polypeptide binding]; other site
216597010139	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
216597010140	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
216597010141	active site
216597010142	FMN binding site [chemical binding]; other site
216597010143	substrate binding site [chemical binding]; other site
216597010144	3Fe-4S cluster binding site [ion binding]; other site
216597010145	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
216597010146	domain interface; other site
216597010147	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
216597010148	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216597010149	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216597010150	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
216597010151	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
216597010152	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
216597010153	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
216597010154	Na binding site [ion binding]; other site
216597010155	putative substrate binding site [chemical binding]; other site
216597010156	cytosine deaminase; Provisional; Region: PRK09230
216597010157	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
216597010158	active site
216597010159	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
216597010160	N-acetylmannosamine kinase; Provisional; Region: PRK05082
216597010161	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
216597010162	nucleotide binding site [chemical binding]; other site
216597010163	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
216597010164	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
216597010165	putative active site cavity [active]
216597010166	putative sialic acid transporter; Provisional; Region: PRK03893
216597010167	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597010168	putative substrate translocation pore; other site
216597010169	N-acetylneuraminate lyase; Provisional; Region: PRK04147
216597010170	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
216597010171	inhibitor site; inhibition site
216597010172	active site
216597010173	dimer interface [polypeptide binding]; other site
216597010174	catalytic residue [active]
216597010175	transcriptional regulator NanR; Provisional; Region: PRK03837
216597010176	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597010177	DNA-binding site [nucleotide binding]; DNA binding site
216597010178	FCD domain; Region: FCD; pfam07729
216597010179	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
216597010180	stringent starvation protein A; Provisional; Region: sspA; PRK09481
216597010181	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
216597010182	C-terminal domain interface [polypeptide binding]; other site
216597010183	putative GSH binding site (G-site) [chemical binding]; other site
216597010184	dimer interface [polypeptide binding]; other site
216597010185	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
216597010186	dimer interface [polypeptide binding]; other site
216597010187	N-terminal domain interface [polypeptide binding]; other site
216597010188	Family of unknown function (DUF695); Region: DUF695; pfam05117
216597010189	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
216597010190	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
216597010191	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
216597010192	23S rRNA interface [nucleotide binding]; other site
216597010193	L3 interface [polypeptide binding]; other site
216597010194	Predicted ATPase [General function prediction only]; Region: COG1485
216597010195	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
216597010196	hypothetical protein; Provisional; Region: PRK11677
216597010197	serine endoprotease; Provisional; Region: PRK10139
216597010198	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
216597010199	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
216597010200	protein binding site [polypeptide binding]; other site
216597010201	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
216597010202	serine endoprotease; Provisional; Region: PRK10898
216597010203	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
216597010204	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
216597010205	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
216597010206	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
216597010207	oxaloacetate decarboxylase; Provisional; Region: PRK14040
216597010208	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
216597010209	active site
216597010210	catalytic residues [active]
216597010211	metal binding site [ion binding]; metal-binding site
216597010212	homodimer binding site [polypeptide binding]; other site
216597010213	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
216597010214	carboxyltransferase (CT) interaction site; other site
216597010215	biotinylation site [posttranslational modification]; other site
216597010216	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
216597010217	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
216597010218	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
216597010219	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
216597010220	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
216597010221	transmembrane helices; other site
216597010222	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216597010223	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597010224	DNA-binding site [nucleotide binding]; DNA binding site
216597010225	FCD domain; Region: FCD; pfam07729
216597010226	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216597010227	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597010228	DNA-binding site [nucleotide binding]; DNA binding site
216597010229	malate dehydrogenase; Provisional; Region: PRK05086
216597010230	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
216597010231	NAD binding site [chemical binding]; other site
216597010232	dimerization interface [polypeptide binding]; other site
216597010233	Substrate binding site [chemical binding]; other site
216597010234	arginine repressor; Provisional; Region: PRK05066
216597010235	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
216597010236	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
216597010237	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
216597010238	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
216597010239	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
216597010240	RNAase interaction site [polypeptide binding]; other site
216597010241	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
216597010242	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
216597010243	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
216597010244	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216597010245	HlyD family secretion protein; Region: HlyD_3; pfam13437
216597010246	efflux system membrane protein; Provisional; Region: PRK11594
216597010247	transcriptional regulator; Provisional; Region: PRK10632
216597010248	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597010249	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216597010250	putative effector binding pocket; other site
216597010251	dimerization interface [polypeptide binding]; other site
216597010252	protease TldD; Provisional; Region: tldD; PRK10735
216597010253	hypothetical protein; Provisional; Region: PRK10899
216597010254	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
216597010255	ribonuclease G; Provisional; Region: PRK11712
216597010256	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
216597010257	homodimer interface [polypeptide binding]; other site
216597010258	oligonucleotide binding site [chemical binding]; other site
216597010259	Maf-like protein; Region: Maf; pfam02545
216597010260	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
216597010261	active site
216597010262	dimer interface [polypeptide binding]; other site
216597010263	rod shape-determining protein MreD; Provisional; Region: PRK11060
216597010264	rod shape-determining protein MreC; Region: mreC; TIGR00219
216597010265	rod shape-determining protein MreC; Region: MreC; pfam04085
216597010266	rod shape-determining protein MreB; Provisional; Region: PRK13927
216597010267	MreB and similar proteins; Region: MreB_like; cd10225
216597010268	nucleotide binding site [chemical binding]; other site
216597010269	Mg binding site [ion binding]; other site
216597010270	putative protofilament interaction site [polypeptide binding]; other site
216597010271	RodZ interaction site [polypeptide binding]; other site
216597010272	regulatory protein CsrD; Provisional; Region: PRK11059
216597010273	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216597010274	metal binding site [ion binding]; metal-binding site
216597010275	active site
216597010276	I-site; other site
216597010277	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597010278	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
216597010279	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
216597010280	NADP binding site [chemical binding]; other site
216597010281	dimer interface [polypeptide binding]; other site
216597010282	TMAO/DMSO reductase; Reviewed; Region: PRK05363
216597010283	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
216597010284	Moco binding site; other site
216597010285	metal coordination site [ion binding]; other site
216597010286	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
216597010287	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
216597010288	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
216597010289	carboxyltransferase (CT) interaction site; other site
216597010290	biotinylation site [posttranslational modification]; other site
216597010291	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216597010292	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
216597010293	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
216597010294	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
216597010295	hypothetical protein; Provisional; Region: PRK10633
216597010296	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
216597010297	Na binding site [ion binding]; other site
216597010298	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
216597010299	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
216597010300	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
216597010301	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
216597010302	FMN binding site [chemical binding]; other site
216597010303	active site
216597010304	catalytic residues [active]
216597010305	substrate binding site [chemical binding]; other site
216597010306	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
216597010307	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
216597010308	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
216597010309	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597010310	DNA methylase; Region: N6_N4_Mtase; pfam01555
216597010311	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
216597010312	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
216597010313	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
216597010314	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
216597010315	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216597010316	metal binding site [ion binding]; metal-binding site
216597010317	active site
216597010318	I-site; other site
216597010319	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597010320	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
216597010321	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597010322	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
216597010323	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
216597010324	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216597010325	HlyD family secretion protein; Region: HlyD_3; pfam13437
216597010326	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
216597010327	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
216597010328	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
216597010329	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
216597010330	trimer interface [polypeptide binding]; other site
216597010331	putative metal binding site [ion binding]; other site
216597010332	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
216597010333	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
216597010334	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
216597010335	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
216597010336	shikimate binding site; other site
216597010337	NAD(P) binding site [chemical binding]; other site
216597010338	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
216597010339	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
216597010340	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
216597010341	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
216597010342	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
216597010343	hypothetical protein; Validated; Region: PRK03430
216597010344	hypothetical protein; Provisional; Region: PRK10736
216597010345	DNA protecting protein DprA; Region: dprA; TIGR00732
216597010346	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
216597010347	active site
216597010348	catalytic residues [active]
216597010349	metal binding site [ion binding]; metal-binding site
216597010350	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
216597010351	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
216597010352	putative active site [active]
216597010353	substrate binding site [chemical binding]; other site
216597010354	putative cosubstrate binding site; other site
216597010355	catalytic site [active]
216597010356	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
216597010357	substrate binding site [chemical binding]; other site
216597010358	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
216597010359	putative RNA binding site [nucleotide binding]; other site
216597010360	16S rRNA methyltransferase B; Provisional; Region: PRK10901
216597010361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597010362	S-adenosylmethionine binding site [chemical binding]; other site
216597010363	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
216597010364	TrkA-N domain; Region: TrkA_N; pfam02254
216597010365	TrkA-C domain; Region: TrkA_C; pfam02080
216597010366	TrkA-N domain; Region: TrkA_N; pfam02254
216597010367	TrkA-C domain; Region: TrkA_C; pfam02080
216597010368	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
216597010369	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
216597010370	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
216597010371	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
216597010372	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
216597010373	DNA binding residues [nucleotide binding]
216597010374	dimer interface [polypeptide binding]; other site
216597010375	metal binding site [ion binding]; metal-binding site
216597010376	hypothetical protein; Provisional; Region: PRK10203
216597010377	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
216597010378	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
216597010379	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
216597010380	alphaNTD homodimer interface [polypeptide binding]; other site
216597010381	alphaNTD - beta interaction site [polypeptide binding]; other site
216597010382	alphaNTD - beta' interaction site [polypeptide binding]; other site
216597010383	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
216597010384	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
216597010385	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
216597010386	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216597010387	RNA binding surface [nucleotide binding]; other site
216597010388	30S ribosomal protein S11; Validated; Region: PRK05309
216597010389	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
216597010390	30S ribosomal protein S13; Region: bact_S13; TIGR03631
216597010391	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
216597010392	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
216597010393	SecY translocase; Region: SecY; pfam00344
216597010394	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
216597010395	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
216597010396	23S rRNA binding site [nucleotide binding]; other site
216597010397	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
216597010398	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
216597010399	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
216597010400	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
216597010401	23S rRNA interface [nucleotide binding]; other site
216597010402	5S rRNA interface [nucleotide binding]; other site
216597010403	L27 interface [polypeptide binding]; other site
216597010404	L5 interface [polypeptide binding]; other site
216597010405	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
216597010406	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
216597010407	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
216597010408	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
216597010409	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
216597010410	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
216597010411	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
216597010412	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
216597010413	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
216597010414	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
216597010415	RNA binding site [nucleotide binding]; other site
216597010416	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
216597010417	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
216597010418	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
216597010419	23S rRNA interface [nucleotide binding]; other site
216597010420	putative translocon interaction site; other site
216597010421	signal recognition particle (SRP54) interaction site; other site
216597010422	L23 interface [polypeptide binding]; other site
216597010423	trigger factor interaction site; other site
216597010424	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
216597010425	23S rRNA interface [nucleotide binding]; other site
216597010426	5S rRNA interface [nucleotide binding]; other site
216597010427	putative antibiotic binding site [chemical binding]; other site
216597010428	L25 interface [polypeptide binding]; other site
216597010429	L27 interface [polypeptide binding]; other site
216597010430	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
216597010431	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
216597010432	G-X-X-G motif; other site
216597010433	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
216597010434	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
216597010435	protein-rRNA interface [nucleotide binding]; other site
216597010436	putative translocon binding site; other site
216597010437	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
216597010438	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
216597010439	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
216597010440	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
216597010441	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
216597010442	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
216597010443	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
216597010444	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
216597010445	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
216597010446	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
216597010447	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
216597010448	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
216597010449	heme binding site [chemical binding]; other site
216597010450	ferroxidase pore; other site
216597010451	ferroxidase diiron center [ion binding]; other site
216597010452	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
216597010453	elongation factor Tu; Reviewed; Region: PRK00049
216597010454	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
216597010455	G1 box; other site
216597010456	GEF interaction site [polypeptide binding]; other site
216597010457	GTP/Mg2+ binding site [chemical binding]; other site
216597010458	Switch I region; other site
216597010459	G2 box; other site
216597010460	G3 box; other site
216597010461	Switch II region; other site
216597010462	G4 box; other site
216597010463	G5 box; other site
216597010464	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
216597010465	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
216597010466	Antibiotic Binding Site [chemical binding]; other site
216597010467	elongation factor G; Reviewed; Region: PRK00007
216597010468	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
216597010469	G1 box; other site
216597010470	putative GEF interaction site [polypeptide binding]; other site
216597010471	GTP/Mg2+ binding site [chemical binding]; other site
216597010472	Switch I region; other site
216597010473	G2 box; other site
216597010474	G3 box; other site
216597010475	Switch II region; other site
216597010476	G4 box; other site
216597010477	G5 box; other site
216597010478	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
216597010479	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
216597010480	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
216597010481	30S ribosomal protein S7; Validated; Region: PRK05302
216597010482	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
216597010483	S17 interaction site [polypeptide binding]; other site
216597010484	S8 interaction site; other site
216597010485	16S rRNA interaction site [nucleotide binding]; other site
216597010486	streptomycin interaction site [chemical binding]; other site
216597010487	23S rRNA interaction site [nucleotide binding]; other site
216597010488	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
216597010489	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
216597010490	sulfur relay protein TusC; Validated; Region: PRK00211
216597010491	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
216597010492	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
216597010493	YheO-like PAS domain; Region: PAS_6; pfam08348
216597010494	HTH domain; Region: HTH_22; pfam13309
216597010495	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
216597010496	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
216597010497	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
216597010498	phi X174 lysis protein; Provisional; Region: PRK02793
216597010499	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
216597010500	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
216597010501	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
216597010502	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
216597010503	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
216597010504	TrkA-N domain; Region: TrkA_N; pfam02254
216597010505	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
216597010506	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
216597010507	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597010508	Walker A/P-loop; other site
216597010509	ATP binding site [chemical binding]; other site
216597010510	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216597010511	ABC transporter signature motif; other site
216597010512	Walker B; other site
216597010513	D-loop; other site
216597010514	ABC transporter; Region: ABC_tran_2; pfam12848
216597010515	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216597010516	putative monooxygenase; Provisional; Region: PRK11118
216597010517	putative hydrolase; Provisional; Region: PRK10985
216597010518	SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755
216597010519	hypothetical protein; Provisional; Region: PRK04966
216597010520	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
216597010521	active site
216597010522	hypothetical protein; Provisional; Region: PRK10738
216597010523	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
216597010524	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
216597010525	ligand binding site [chemical binding]; other site
216597010526	flexible hinge region; other site
216597010527	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
216597010528	putative switch regulator; other site
216597010529	non-specific DNA interactions [nucleotide binding]; other site
216597010530	DNA binding site [nucleotide binding]
216597010531	sequence specific DNA binding site [nucleotide binding]; other site
216597010532	putative cAMP binding site [chemical binding]; other site
216597010533	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
216597010534	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
216597010535	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
216597010536	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
216597010537	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216597010538	inhibitor-cofactor binding pocket; inhibition site
216597010539	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597010540	catalytic residue [active]
216597010541	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
216597010542	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
216597010543	glutamine binding [chemical binding]; other site
216597010544	catalytic triad [active]
216597010545	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
216597010546	cell filamentation protein Fic; Provisional; Region: PRK10347
216597010547	hypothetical protein; Provisional; Region: PRK10204
216597010548	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
216597010549	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
216597010550	substrate binding site [chemical binding]; other site
216597010551	putative transporter; Provisional; Region: PRK03699
216597010552	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597010553	putative substrate translocation pore; other site
216597010554	nitrite reductase subunit NirD; Provisional; Region: PRK14989
216597010555	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216597010556	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
216597010557	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
216597010558	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
216597010559	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
216597010560	nitrite transporter NirC; Provisional; Region: PRK11562
216597010561	siroheme synthase; Provisional; Region: cysG; PRK10637
216597010562	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
216597010563	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
216597010564	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
216597010565	active site
216597010566	SAM binding site [chemical binding]; other site
216597010567	homodimer interface [polypeptide binding]; other site
216597010568	Autotransporter beta-domain; Region: Autotransporter; pfam03797
216597010569	Transposase IS200 like; Region: Y1_Tnp; pfam01797
216597010570	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
216597010571	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
216597010572	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
216597010573	active site
216597010574	HIGH motif; other site
216597010575	dimer interface [polypeptide binding]; other site
216597010576	KMSKS motif; other site
216597010577	phosphoglycolate phosphatase; Provisional; Region: PRK13222
216597010578	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597010579	motif II; other site
216597010580	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
216597010581	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
216597010582	substrate binding site [chemical binding]; other site
216597010583	hexamer interface [polypeptide binding]; other site
216597010584	metal binding site [ion binding]; metal-binding site
216597010585	DNA adenine methylase; Provisional; Region: PRK10904
216597010586	cell division protein DamX; Validated; Region: PRK10905
216597010587	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
216597010588	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
216597010589	active site
216597010590	dimer interface [polypeptide binding]; other site
216597010591	metal binding site [ion binding]; metal-binding site
216597010592	shikimate kinase; Reviewed; Region: aroK; PRK00131
216597010593	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
216597010594	ADP binding site [chemical binding]; other site
216597010595	magnesium binding site [ion binding]; other site
216597010596	putative shikimate binding site; other site
216597010597	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
216597010598	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
216597010599	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
216597010600	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
216597010601	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
216597010602	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
216597010603	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
216597010604	Transglycosylase; Region: Transgly; pfam00912
216597010605	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
216597010606	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
216597010607	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
216597010608	ADP-ribose binding site [chemical binding]; other site
216597010609	dimer interface [polypeptide binding]; other site
216597010610	active site
216597010611	nudix motif; other site
216597010612	metal binding site [ion binding]; metal-binding site
216597010613	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
216597010614	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
216597010615	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597010616	motif II; other site
216597010617	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216597010618	RNA binding surface [nucleotide binding]; other site
216597010619	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
216597010620	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
216597010621	dimerization interface [polypeptide binding]; other site
216597010622	domain crossover interface; other site
216597010623	redox-dependent activation switch; other site
216597010624	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
216597010625	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
216597010626	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
216597010627	active site
216597010628	substrate-binding site [chemical binding]; other site
216597010629	metal-binding site [ion binding]
216597010630	ATP binding site [chemical binding]; other site
216597010631	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
216597010632	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597010633	dimerization interface [polypeptide binding]; other site
216597010634	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597010635	dimer interface [polypeptide binding]; other site
216597010636	phosphorylation site [posttranslational modification]
216597010637	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597010638	ATP binding site [chemical binding]; other site
216597010639	G-X-G motif; other site
216597010640	osmolarity response regulator; Provisional; Region: ompR; PRK09468
216597010641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597010642	active site
216597010643	phosphorylation site [posttranslational modification]
216597010644	intermolecular recognition site; other site
216597010645	dimerization interface [polypeptide binding]; other site
216597010646	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597010647	DNA binding site [nucleotide binding]
216597010648	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
216597010649	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
216597010650	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
216597010651	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
216597010652	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
216597010653	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
216597010654	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
216597010655	RNA binding site [nucleotide binding]; other site
216597010656	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
216597010657	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
216597010658	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
216597010659	G1 box; other site
216597010660	GTP/Mg2+ binding site [chemical binding]; other site
216597010661	Switch I region; other site
216597010662	G2 box; other site
216597010663	G3 box; other site
216597010664	Switch II region; other site
216597010665	G4 box; other site
216597010666	G5 box; other site
216597010667	Nucleoside recognition; Region: Gate; pfam07670
216597010668	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
216597010669	Nucleoside recognition; Region: Gate; pfam07670
216597010670	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
216597010671	hypothetical protein; Provisional; Region: PRK09956
216597010672	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
216597010673	carboxylesterase BioH; Provisional; Region: PRK10349
216597010674	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
216597010675	DNA utilization protein GntX; Provisional; Region: PRK11595
216597010676	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216597010677	active site
216597010678	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
216597010679	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
216597010680	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
216597010681	high-affinity gluconate transporter; Provisional; Region: PRK14984
216597010682	gluconate transporter; Region: gntP; TIGR00791
216597010683	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
216597010684	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
216597010685	maltodextrin phosphorylase; Provisional; Region: PRK14985
216597010686	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
216597010687	homodimer interface [polypeptide binding]; other site
216597010688	active site pocket [active]
216597010689	transcriptional regulator MalT; Provisional; Region: PRK04841
216597010690	AAA ATPase domain; Region: AAA_16; pfam13191
216597010691	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597010692	DNA binding residues [nucleotide binding]
216597010693	dimerization interface [polypeptide binding]; other site
216597010694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
216597010695	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
216597010696	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
216597010697	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
216597010698	putative active site [active]
216597010699	adenylation catalytic residue [active]
216597010700	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
216597010701	hypothetical protein; Reviewed; Region: PRK09588
216597010702	TROVE domain; Region: TROVE; pfam05731
216597010703	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
216597010704	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
216597010705	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597010706	Walker A motif; other site
216597010707	ATP binding site [chemical binding]; other site
216597010708	Walker B motif; other site
216597010709	arginine finger; other site
216597010711	intramembrane serine protease GlpG; Provisional; Region: PRK10907
216597010712	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
216597010713	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
216597010714	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
216597010715	active site residue [active]
216597010716	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
216597010717	hypothetical protein; Provisional; Region: PRK09781
216597010718	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
216597010719	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
216597010720	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
216597010721	dimer interface [polypeptide binding]; other site
216597010722	active site
216597010723	metal binding site [ion binding]; metal-binding site
216597010724	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597010725	D-galactonate transporter; Region: 2A0114; TIGR00893
216597010726	putative substrate translocation pore; other site
216597010727	Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129
216597010728	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
216597010729	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
216597010730	inhibitor site; inhibition site
216597010731	active site
216597010732	dimer interface [polypeptide binding]; other site
216597010733	catalytic residue [active]
216597010734	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
216597010735	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216597010736	Bacterial transcriptional regulator; Region: IclR; pfam01614
216597010737	glycogen phosphorylase; Provisional; Region: PRK14986
216597010738	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
216597010739	homodimer interface [polypeptide binding]; other site
216597010740	active site pocket [active]
216597010741	glycogen synthase; Provisional; Region: glgA; PRK00654
216597010742	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
216597010743	ADP-binding pocket [chemical binding]; other site
216597010744	homodimer interface [polypeptide binding]; other site
216597010745	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
216597010746	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
216597010747	ligand binding site; other site
216597010748	oligomer interface; other site
216597010749	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
216597010750	dimer interface [polypeptide binding]; other site
216597010751	N-terminal domain interface [polypeptide binding]; other site
216597010752	sulfate 1 binding site; other site
216597010753	glycogen debranching enzyme; Provisional; Region: PRK03705
216597010754	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
216597010755	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
216597010756	active site
216597010757	catalytic site [active]
216597010758	glycogen branching enzyme; Provisional; Region: PRK05402
216597010759	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
216597010760	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
216597010761	active site
216597010762	catalytic site [active]
216597010763	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
216597010764	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
216597010765	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
216597010766	low affinity gluconate transporter; Provisional; Region: PRK10472
216597010767	gluconate transporter; Region: gntP; TIGR00791
216597010768	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
216597010769	ATP-binding site [chemical binding]; other site
216597010770	Gluconate-6-phosphate binding site [chemical binding]; other site
216597010771	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
216597010772	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597010773	DNA binding site [nucleotide binding]
216597010774	domain linker motif; other site
216597010775	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
216597010776	putative ligand binding site [chemical binding]; other site
216597010777	putative dimerization interface [polypeptide binding]; other site
216597010778	Pirin-related protein [General function prediction only]; Region: COG1741
216597010779	Pirin; Region: Pirin; pfam02678
216597010780	putative oxidoreductase; Provisional; Region: PRK10206
216597010781	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216597010782	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
216597010783	putative acetyltransferase YhhY; Provisional; Region: PRK10140
216597010784	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597010785	Coenzyme A binding pocket [chemical binding]; other site
216597010786	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216597010787	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
216597010788	substrate binding site [chemical binding]; other site
216597010789	dimer interface [polypeptide binding]; other site
216597010790	ATP binding site [chemical binding]; other site
216597010791	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
216597010792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
216597010793	Protein of unknown function, DUF606; Region: DUF606; pfam04657
216597010794	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
216597010795	active site
216597010796	substrate binding pocket [chemical binding]; other site
216597010797	homodimer interaction site [polypeptide binding]; other site
216597010798	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
216597010799	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
216597010800	hypothetical protein; Provisional; Region: PRK10350
216597010801	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
216597010802	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
216597010803	putative active site [active]
216597010804	catalytic site [active]
216597010805	putative metal binding site [ion binding]; other site
216597010806	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
216597010807	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
216597010808	Walker A/P-loop; other site
216597010809	ATP binding site [chemical binding]; other site
216597010810	Q-loop/lid; other site
216597010811	ABC transporter signature motif; other site
216597010812	Walker B; other site
216597010813	D-loop; other site
216597010814	H-loop/switch region; other site
216597010815	TOBE domain; Region: TOBE_2; pfam08402
216597010816	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
216597010817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597010818	dimer interface [polypeptide binding]; other site
216597010819	conserved gate region; other site
216597010820	ABC-ATPase subunit interface; other site
216597010821	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
216597010822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597010823	dimer interface [polypeptide binding]; other site
216597010824	conserved gate region; other site
216597010825	putative PBP binding loops; other site
216597010826	ABC-ATPase subunit interface; other site
216597010827	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
216597010828	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
216597010829	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
216597010830	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
216597010831	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
216597010832	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
216597010833	Walker A/P-loop; other site
216597010834	ATP binding site [chemical binding]; other site
216597010835	Q-loop/lid; other site
216597010836	ABC transporter signature motif; other site
216597010837	Walker B; other site
216597010838	D-loop; other site
216597010839	H-loop/switch region; other site
216597010840	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
216597010841	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
216597010842	Walker A/P-loop; other site
216597010843	ATP binding site [chemical binding]; other site
216597010844	Q-loop/lid; other site
216597010845	ABC transporter signature motif; other site
216597010846	Walker B; other site
216597010847	D-loop; other site
216597010848	H-loop/switch region; other site
216597010849	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
216597010850	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
216597010851	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
216597010852	TM-ABC transporter signature motif; other site
216597010853	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216597010854	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
216597010855	TM-ABC transporter signature motif; other site
216597010856	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
216597010857	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
216597010858	dimerization interface [polypeptide binding]; other site
216597010859	ligand binding site [chemical binding]; other site
216597010860	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
216597010861	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
216597010862	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
216597010863	dimerization interface [polypeptide binding]; other site
216597010864	ligand binding site [chemical binding]; other site
216597010865	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
216597010866	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216597010867	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216597010868	DNA binding residues [nucleotide binding]
216597010869	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
216597010870	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
216597010871	cell division protein FtsE; Provisional; Region: PRK10908
216597010872	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597010873	Walker A/P-loop; other site
216597010874	ATP binding site [chemical binding]; other site
216597010875	Q-loop/lid; other site
216597010876	ABC transporter signature motif; other site
216597010877	Walker B; other site
216597010878	D-loop; other site
216597010879	H-loop/switch region; other site
216597010880	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
216597010881	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
216597010882	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
216597010883	P loop; other site
216597010884	GTP binding site [chemical binding]; other site
216597010885	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
216597010886	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597010887	S-adenosylmethionine binding site [chemical binding]; other site
216597010888	hypothetical protein; Provisional; Region: PRK10910
216597010889	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
216597010890	Predicted membrane protein [Function unknown]; Region: COG3714
216597010891	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
216597010892	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
216597010893	metal-binding site [ion binding]
216597010894	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216597010895	Soluble P-type ATPase [General function prediction only]; Region: COG4087
216597010896	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
216597010897	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
216597010898	dimer interface [polypeptide binding]; other site
216597010899	ligand binding site [chemical binding]; other site
216597010900	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597010901	dimerization interface [polypeptide binding]; other site
216597010902	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216597010903	dimer interface [polypeptide binding]; other site
216597010904	putative CheW interface [polypeptide binding]; other site
216597010905	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
216597010906	CPxP  motif; other site
216597010907	hypothetical protein; Provisional; Region: PRK11212
216597010908	hypothetical protein; Provisional; Region: PRK11615
216597010909	major facilitator superfamily transporter; Provisional; Region: PRK05122
216597010910	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597010911	putative substrate translocation pore; other site
216597010912	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
216597010913	Domain of unknown function DUF20; Region: UPF0118; pfam01594
216597010914	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
216597010915	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
216597010916	nickel responsive regulator; Provisional; Region: PRK02967
216597010917	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
216597010918	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
216597010919	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
216597010920	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
216597010921	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
216597010922	Walker A/P-loop; other site
216597010923	ATP binding site [chemical binding]; other site
216597010924	Q-loop/lid; other site
216597010925	ABC transporter signature motif; other site
216597010926	Walker B; other site
216597010927	D-loop; other site
216597010928	H-loop/switch region; other site
216597010929	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
216597010930	Walker A/P-loop; other site
216597010931	ATP binding site [chemical binding]; other site
216597010932	Q-loop/lid; other site
216597010933	ABC transporter signature motif; other site
216597010934	Walker B; other site
216597010935	D-loop; other site
216597010936	H-loop/switch region; other site
216597010937	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
216597010938	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
216597010939	HlyD family secretion protein; Region: HlyD; pfam00529
216597010940	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216597010941	HlyD family secretion protein; Region: HlyD_3; pfam13437
216597010942	Predicted flavoproteins [General function prediction only]; Region: COG2081
216597010943	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216597010944	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
216597010945	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
216597010946	universal stress protein UspB; Provisional; Region: PRK04960
216597010947	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216597010948	Ligand Binding Site [chemical binding]; other site
216597010949	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
216597010950	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597010951	putative substrate translocation pore; other site
216597010952	POT family; Region: PTR2; pfam00854
216597010953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597010954	S-adenosylmethionine binding site [chemical binding]; other site
216597010955	oligopeptidase A; Provisional; Region: PRK10911
216597010956	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
216597010957	active site
216597010958	Zn binding site [ion binding]; other site
216597010959	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
216597010960	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
216597010961	active site
216597010962	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
216597010963	glutathione reductase; Validated; Region: PRK06116
216597010964	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216597010965	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216597010966	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
216597010967	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
216597010968	active site
216597010969	homodimer interface [polypeptide binding]; other site
216597010970	homotetramer interface [polypeptide binding]; other site
216597010971	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
216597010972	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
216597010973	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
216597010974	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216597010975	substrate binding site [chemical binding]; other site
216597010976	ATP binding site [chemical binding]; other site
216597010977	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
216597010978	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
216597010979	putative active site [active]
216597010980	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
216597010981	dimer interface [polypeptide binding]; other site
216597010982	active site
216597010983	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
216597010984	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597010985	DNA-binding site [nucleotide binding]; DNA binding site
216597010986	UTRA domain; Region: UTRA; pfam07702
216597010987	trehalase; Provisional; Region: treF; PRK13270
216597010988	Trehalase; Region: Trehalase; pfam01204
216597010989	Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772
216597010990	catalytic residue [active]
216597010991	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216597010992	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597010993	DNA binding residues [nucleotide binding]
216597010994	dimerization interface [polypeptide binding]; other site
216597010995	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597010996	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597010997	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
216597010998	putative effector binding pocket; other site
216597010999	putative dimerization interface [polypeptide binding]; other site
216597011000	inner membrane protein YhjD; Region: TIGR00766
216597011001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597011002	metabolite-proton symporter; Region: 2A0106; TIGR00883
216597011003	putative substrate translocation pore; other site
216597011004	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
216597011005	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
216597011006	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597011007	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216597011008	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
216597011009	substrate binding site [chemical binding]; other site
216597011010	ATP binding site [chemical binding]; other site
216597011011	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
216597011012	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
216597011013	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
216597011014	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216597011015	putative diguanylate cyclase; Provisional; Region: PRK13561
216597011016	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216597011017	metal binding site [ion binding]; metal-binding site
216597011018	active site
216597011019	I-site; other site
216597011020	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597011021	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
216597011022	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
216597011023	TPR motif; other site
216597011024	binding surface
216597011025	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216597011026	TPR motif; other site
216597011027	binding surface
216597011028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216597011029	binding surface
216597011030	TPR motif; other site
216597011031	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
216597011032	endo-1,4-D-glucanase; Provisional; Region: PRK11097
216597011033	cellulose synthase regulator protein; Provisional; Region: PRK11114
216597011034	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
216597011035	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216597011036	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
216597011037	DXD motif; other site
216597011038	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216597011039	PilZ domain; Region: PilZ; pfam07238
216597011040	cell division protein; Provisional; Region: PRK10037
216597011041	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
216597011042	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
216597011043	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
216597011044	Protein of unknown function (DUF2636); Region: DUF2636; pfam11120
216597011045	cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368
216597011047	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
216597011048	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
216597011049	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
216597011050	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216597011051	Walker A/P-loop; other site
216597011052	ATP binding site [chemical binding]; other site
216597011053	Q-loop/lid; other site
216597011054	ABC transporter signature motif; other site
216597011055	Walker B; other site
216597011056	D-loop; other site
216597011057	H-loop/switch region; other site
216597011058	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
216597011059	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
216597011060	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216597011061	Walker A/P-loop; other site
216597011062	ATP binding site [chemical binding]; other site
216597011063	Q-loop/lid; other site
216597011064	ABC transporter signature motif; other site
216597011065	Walker B; other site
216597011066	D-loop; other site
216597011067	H-loop/switch region; other site
216597011068	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
216597011069	dipeptide transporter; Provisional; Region: PRK10913
216597011070	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
216597011071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597011072	dimer interface [polypeptide binding]; other site
216597011073	conserved gate region; other site
216597011074	putative PBP binding loops; other site
216597011075	ABC-ATPase subunit interface; other site
216597011076	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
216597011077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597011078	dimer interface [polypeptide binding]; other site
216597011079	conserved gate region; other site
216597011080	putative PBP binding loops; other site
216597011081	ABC-ATPase subunit interface; other site
216597011082	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
216597011083	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
216597011084	peptide binding site [polypeptide binding]; other site
216597011085	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
216597011086	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
216597011087	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216597011088	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597011089	DNA binding site [nucleotide binding]
216597011090	domain linker motif; other site
216597011091	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287
216597011092	putative dimerization interface [polypeptide binding]; other site
216597011093	putative ligand binding site [chemical binding]; other site
216597011094	phosphoethanolamine transferase; Provisional; Region: PRK11560
216597011095	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
216597011096	Sulfatase; Region: Sulfatase; pfam00884
216597011097	long polar fimbrial protein LpfE; Provisional; Region: PRK15205
216597011099	long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207
216597011100	PapC N-terminal domain; Region: PapC_N; pfam13954
216597011101	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216597011102	PapC C-terminal domain; Region: PapC_C; pfam13953
216597011103	long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208
216597011104	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597011105	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597011106	long polar fimbrial protein LpfA; Provisional; Region: PRK15209
216597011107	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
216597011108	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
216597011109	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597011110	Coenzyme A binding pocket [chemical binding]; other site
216597011111	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
216597011112	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
216597011113	molybdopterin cofactor binding site [chemical binding]; other site
216597011114	substrate binding site [chemical binding]; other site
216597011115	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
216597011116	molybdopterin cofactor binding site; other site
216597011117	putative outer membrane lipoprotein; Provisional; Region: PRK10510
216597011118	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216597011119	ligand binding site [chemical binding]; other site
216597011120	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
216597011121	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
216597011122	dimerization interface [polypeptide binding]; other site
216597011123	ligand binding site [chemical binding]; other site
216597011124	NADP binding site [chemical binding]; other site
216597011125	catalytic site [active]
216597011126	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
216597011127	Predicted transcriptional regulator [Transcription]; Region: COG2944
216597011128	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597011129	salt bridge; other site
216597011130	non-specific DNA binding site [nucleotide binding]; other site
216597011131	sequence-specific DNA binding site [nucleotide binding]; other site
216597011132	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
216597011133	DNA-binding site [nucleotide binding]; DNA binding site
216597011134	RNA-binding motif; other site
216597011135	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
216597011136	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
216597011137	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
216597011138	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597011139	Coenzyme A binding pocket [chemical binding]; other site
216597011140	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
216597011141	DALR anticodon binding domain; Region: DALR_1; pfam05746
216597011142	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
216597011143	dimer interface [polypeptide binding]; other site
216597011144	motif 1; other site
216597011145	active site
216597011146	motif 2; other site
216597011147	motif 3; other site
216597011148	YsaB-like lipoprotein; Region: YsaB; pfam13983
216597011149	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
216597011150	Acyltransferase family; Region: Acyl_transf_3; pfam01757
216597011151	Predicted membrane protein [Function unknown]; Region: COG4682
216597011152	yiaA/B two helix domain; Region: YiaAB; cl01759
216597011153	yiaA/B two helix domain; Region: YiaAB; cl01759
216597011154	xylulokinase; Provisional; Region: PRK15027
216597011155	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
216597011156	N- and C-terminal domain interface [polypeptide binding]; other site
216597011157	active site
216597011158	MgATP binding site [chemical binding]; other site
216597011159	catalytic site [active]
216597011160	metal binding site [ion binding]; metal-binding site
216597011161	xylulose binding site [chemical binding]; other site
216597011162	homodimer interface [polypeptide binding]; other site
216597011163	xylose isomerase; Provisional; Region: PRK05474
216597011164	xylose isomerase; Region: xylose_isom_A; TIGR02630
216597011165	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
216597011166	putative dimerization interface [polypeptide binding]; other site
216597011167	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216597011168	putative ligand binding site [chemical binding]; other site
216597011169	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597011170	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216597011171	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597011172	hypothetical protein; Provisional; Region: PRK10356
216597011173	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
216597011174	alpha-amylase; Reviewed; Region: malS; PRK09505
216597011175	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
216597011176	active site
216597011177	catalytic site [active]
216597011178	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
216597011179	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216597011180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597011181	homodimer interface [polypeptide binding]; other site
216597011182	catalytic residue [active]
216597011183	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
216597011184	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216597011185	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
216597011186	Bacterial transcriptional regulator; Region: IclR; pfam01614
216597011187	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
216597011188	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
216597011189	2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877
216597011190	L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060
216597011191	DctM-like transporters; Region: DctM; pfam06808
216597011192	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
216597011193	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
216597011194	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
216597011195	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
216597011196	putative N- and C-terminal domain interface [polypeptide binding]; other site
216597011197	putative active site [active]
216597011198	MgATP binding site [chemical binding]; other site
216597011199	catalytic site [active]
216597011200	metal binding site [ion binding]; metal-binding site
216597011201	putative xylulose binding site [chemical binding]; other site
216597011202	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
216597011203	active site
216597011204	dimer interface [polypeptide binding]; other site
216597011205	magnesium binding site [ion binding]; other site
216597011206	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
216597011207	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
216597011208	AP (apurinic/apyrimidinic) site pocket; other site
216597011209	DNA interaction; other site
216597011210	Metal-binding active site; metal-binding site
216597011211	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
216597011212	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
216597011213	intersubunit interface [polypeptide binding]; other site
216597011214	active site
216597011215	Zn2+ binding site [ion binding]; other site
216597011216	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216597011217	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216597011218	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597011219	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
216597011220	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
216597011221	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
216597011222	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216597011223	NAD(P) binding site [chemical binding]; other site
216597011224	catalytic residues [active]
216597011225	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
216597011226	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
216597011227	nucleotide binding site [chemical binding]; other site
216597011228	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
216597011229	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
216597011230	G1 box; other site
216597011231	putative GEF interaction site [polypeptide binding]; other site
216597011232	GTP/Mg2+ binding site [chemical binding]; other site
216597011233	Switch I region; other site
216597011234	G2 box; other site
216597011235	G3 box; other site
216597011236	Switch II region; other site
216597011237	G4 box; other site
216597011238	G5 box; other site
216597011239	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
216597011240	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
216597011241	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
216597011242	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
216597011243	selenocysteine synthase; Provisional; Region: PRK04311
216597011244	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
216597011245	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
216597011246	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216597011247	catalytic residue [active]
216597011248	putative glutathione S-transferase; Provisional; Region: PRK10357
216597011249	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
216597011250	putative C-terminal domain interface [polypeptide binding]; other site
216597011251	putative GSH binding site (G-site) [chemical binding]; other site
216597011252	putative dimer interface [polypeptide binding]; other site
216597011253	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
216597011254	dimer interface [polypeptide binding]; other site
216597011255	N-terminal domain interface [polypeptide binding]; other site
216597011256	putative substrate binding pocket (H-site) [chemical binding]; other site
216597011257	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
216597011258	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
216597011259	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
216597011260	active site
216597011261	P-loop; other site
216597011262	phosphorylation site [posttranslational modification]
216597011263	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216597011264	active site
216597011265	phosphorylation site [posttranslational modification]
216597011266	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
216597011267	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
216597011268	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
216597011269	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
216597011270	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
216597011271	hypothetical protein; Provisional; Region: PRK11020
216597011272	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
216597011273	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
216597011274	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
216597011275	trimer interface [polypeptide binding]; other site
216597011276	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
216597011277	Haemagglutinin; Region: HIM; pfam05662
216597011278	Haemagglutinin; Region: HIM; pfam05662
216597011279	YadA-like C-terminal region; Region: YadA; pfam03895
216597011280	L-lactate permease; Provisional; Region: PRK10420
216597011281	glycolate transporter; Provisional; Region: PRK09695
216597011282	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
216597011283	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597011284	DNA-binding site [nucleotide binding]; DNA binding site
216597011285	FCD domain; Region: FCD; pfam07729
216597011286	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
216597011287	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
216597011288	active site
216597011289	substrate binding site [chemical binding]; other site
216597011290	FMN binding site [chemical binding]; other site
216597011291	putative catalytic residues [active]
216597011292	putative rRNA methylase; Provisional; Region: PRK10358
216597011293	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216597011294	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597011295	DNA binding site [nucleotide binding]
216597011296	domain linker motif; other site
216597011297	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
216597011298	putative dimerization interface [polypeptide binding]; other site
216597011299	putative ligand binding site [chemical binding]; other site
216597011300	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
216597011301	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
216597011302	active site pocket [active]
216597011303	potential frameshift: common BLAST hit: gi|197247731|ref|YP_002148631.1| glucarate transporter
216597011304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597011305	D-galactonate transporter; Region: 2A0114; TIGR00893
216597011306	putative substrate translocation pore; other site
216597011307	serine acetyltransferase; Provisional; Region: cysE; PRK11132
216597011308	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
216597011309	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
216597011310	trimer interface [polypeptide binding]; other site
216597011311	active site
216597011312	substrate binding site [chemical binding]; other site
216597011313	CoA binding site [chemical binding]; other site
216597011314	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
216597011315	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
216597011316	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
216597011317	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
216597011318	SecA binding site; other site
216597011319	Preprotein binding site; other site
216597011320	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
216597011321	GSH binding site [chemical binding]; other site
216597011322	catalytic residues [active]
216597011323	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
216597011324	active site residue [active]
216597011325	phosphoglyceromutase; Provisional; Region: PRK05434
216597011326	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
216597011327	AmiB activator; Provisional; Region: PRK11637
216597011328	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
216597011329	Peptidase family M23; Region: Peptidase_M23; pfam01551
216597011330	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
216597011331	NodB motif; other site
216597011332	putative active site [active]
216597011333	putative catalytic site [active]
216597011334	Zn binding site [ion binding]; other site
216597011335	putative glycosyl transferase; Provisional; Region: PRK10073
216597011336	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
216597011337	active site
216597011339	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
216597011340	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
216597011341	NAD(P) binding site [chemical binding]; other site
216597011342	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
216597011343	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
216597011344	substrate-cofactor binding pocket; other site
216597011345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597011346	catalytic residue [active]
216597011347	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
216597011348	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
216597011349	NADP binding site [chemical binding]; other site
216597011350	homopentamer interface [polypeptide binding]; other site
216597011351	substrate binding site [chemical binding]; other site
216597011352	active site
216597011353	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
216597011354	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
216597011355	putative active site [active]
216597011356	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
216597011357	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
216597011358	putative active site [active]
216597011359	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
216597011360	O-antigen ligase RfaL; Provisional; Region: PRK15487
216597011361	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
216597011362	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
216597011363	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526
216597011364	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
216597011365	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
216597011366	Ligand binding site; other site
216597011367	metal-binding site
216597011368	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
216597011369	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
216597011370	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
216597011371	Ligand binding site; other site
216597011372	metal-binding site
216597011373	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
216597011374	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
216597011375	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
216597011376	putative ADP-binding pocket [chemical binding]; other site
216597011377	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
216597011378	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216597011379	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
216597011380	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216597011381	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
216597011382	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
216597011383	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
216597011384	putative active site [active]
216597011385	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
216597011386	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
216597011387	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
216597011388	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
216597011389	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
216597011390	active site
216597011391	(T/H)XGH motif; other site
216597011392	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
216597011393	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
216597011394	DNA binding site [nucleotide binding]
216597011395	catalytic residue [active]
216597011396	H2TH interface [polypeptide binding]; other site
216597011397	putative catalytic residues [active]
216597011398	turnover-facilitating residue; other site
216597011399	intercalation triad [nucleotide binding]; other site
216597011400	8OG recognition residue [nucleotide binding]; other site
216597011401	putative reading head residues; other site
216597011402	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
216597011403	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
216597011404	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
216597011405	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
216597011406	hypothetical protein; Reviewed; Region: PRK00024
216597011407	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
216597011408	MPN+ (JAMM) motif; other site
216597011409	Zinc-binding site [ion binding]; other site
216597011410	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
216597011411	Flavoprotein; Region: Flavoprotein; pfam02441
216597011412	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
216597011413	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
216597011414	trimer interface [polypeptide binding]; other site
216597011415	active site
216597011416	division inhibitor protein; Provisional; Region: slmA; PRK09480
216597011417	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597011418	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216597011419	active site
216597011420	ribonuclease PH; Reviewed; Region: rph; PRK00173
216597011421	Ribonuclease PH; Region: RNase_PH_bact; cd11362
216597011422	hexamer interface [polypeptide binding]; other site
216597011423	active site
216597011424	hypothetical protein; Provisional; Region: PRK11820
216597011425	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
216597011426	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
216597011427	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597011428	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597011429	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216597011430	dimerization interface [polypeptide binding]; other site
216597011431	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
216597011432	Predicted membrane protein [Function unknown]; Region: COG2860
216597011433	UPF0126 domain; Region: UPF0126; pfam03458
216597011434	UPF0126 domain; Region: UPF0126; pfam03458
216597011435	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
216597011436	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
216597011437	nucleotide binding pocket [chemical binding]; other site
216597011438	K-X-D-G motif; other site
216597011439	catalytic site [active]
216597011440	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
216597011441	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
216597011442	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
216597011443	catalytic site [active]
216597011444	G-X2-G-X-G-K; other site
216597011445	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
216597011446	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
216597011447	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216597011448	Zn2+ binding site [ion binding]; other site
216597011449	Mg2+ binding site [ion binding]; other site
216597011450	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
216597011451	synthetase active site [active]
216597011452	NTP binding site [chemical binding]; other site
216597011453	metal binding site [ion binding]; metal-binding site
216597011454	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
216597011455	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
216597011456	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
216597011457	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
216597011458	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
216597011459	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
216597011460	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
216597011461	generic binding surface II; other site
216597011462	ssDNA binding site; other site
216597011463	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216597011464	ATP binding site [chemical binding]; other site
216597011465	putative Mg++ binding site [ion binding]; other site
216597011466	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597011467	nucleotide binding region [chemical binding]; other site
216597011468	ATP-binding site [chemical binding]; other site
216597011469	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
216597011470	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
216597011471	AsmA family; Region: AsmA; pfam05170
216597011472	putative alpha-glucosidase; Provisional; Region: PRK10658
216597011473	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
216597011474	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
216597011475	active site
216597011476	homotrimer interface [polypeptide binding]; other site
216597011477	catalytic site [active]
216597011478	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
216597011479	putative transporter; Provisional; Region: PRK11462
216597011480	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
216597011482	Virulence protein [General function prediction only]; Region: COG3943
216597011483	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
216597011484	autotransport protein MisL; Provisional; Region: PRK15313
216597011485	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
216597011486	Autotransporter beta-domain; Region: Autotransporter; pfam03797
216597011487	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
216597011488	DNA binding site [nucleotide binding]
216597011489	Isochorismatase family; Region: Isochorismatase; pfam00857
216597011490	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
216597011491	catalytic triad [active]
216597011492	dimer interface [polypeptide binding]; other site
216597011493	conserved cis-peptide bond; other site
216597011494	magnesium-transporting ATPase; Provisional; Region: PRK15122
216597011495	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
216597011496	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216597011497	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
216597011498	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597011499	motif II; other site
216597011500	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
216597011501	magnesium transport protein MgtC; Provisional; Region: PRK15385
216597011502	MgtC family; Region: MgtC; pfam02308
216597011503	EamA-like transporter family; Region: EamA; pfam00892
216597011504	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
216597011505	EamA-like transporter family; Region: EamA; pfam00892
216597011506	hypothetical protein; Provisional; Region: PRK09956
216597011507	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
216597011508	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
216597011509	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
216597011510	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
216597011511	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
216597011512	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
216597011513	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
216597011514	active site
216597011515	phosphorylation site [posttranslational modification]
216597011516	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
216597011517	active pocket/dimerization site; other site
216597011518	active site
216597011519	phosphorylation site [posttranslational modification]
216597011520	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
216597011521	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597011522	Walker A motif; other site
216597011523	ATP binding site [chemical binding]; other site
216597011524	Walker B motif; other site
216597011525	arginine finger; other site
216597011526	Transcriptional antiterminator [Transcription]; Region: COG3933
216597011527	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
216597011528	active site
216597011529	active pocket/dimerization site; other site
216597011530	phosphorylation site [posttranslational modification]
216597011531	PRD domain; Region: PRD; pfam00874
216597011532	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
216597011533	beta-galactosidase; Region: BGL; TIGR03356
216597011535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737
216597011536	Predicted transcriptional regulator [Transcription]; Region: COG2944
216597011537	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597011538	non-specific DNA binding site [nucleotide binding]; other site
216597011539	salt bridge; other site
216597011540	sequence-specific DNA binding site [nucleotide binding]; other site
216597011541	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
216597011542	dimerization domain swap beta strand [polypeptide binding]; other site
216597011543	regulatory protein interface [polypeptide binding]; other site
216597011544	active site
216597011545	regulatory phosphorylation site [posttranslational modification]; other site
216597011546	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
216597011547	intersubunit interface [polypeptide binding]; other site
216597011548	active site
216597011549	zinc binding site [ion binding]; other site
216597011550	Na+ binding site [ion binding]; other site
216597011551	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
216597011552	uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774
216597011553	putative N- and C-terminal domain interface [polypeptide binding]; other site
216597011554	putative active site [active]
216597011555	putative MgATP binding site [chemical binding]; other site
216597011556	catalytic site [active]
216597011557	metal binding site [ion binding]; metal-binding site
216597011558	putative carbohydrate binding site [chemical binding]; other site
216597011559	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
216597011560	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
216597011561	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
216597011562	active site
216597011563	P-loop; other site
216597011564	phosphorylation site [posttranslational modification]
216597011565	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216597011566	active site
216597011567	phosphorylation site [posttranslational modification]
216597011568	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
216597011569	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597011570	DNA-binding site [nucleotide binding]; DNA binding site
216597011571	UTRA domain; Region: UTRA; pfam07702
216597011572	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
216597011573	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
216597011574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597011575	putative substrate translocation pore; other site
216597011576	regulatory protein UhpC; Provisional; Region: PRK11663
216597011577	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597011578	putative substrate translocation pore; other site
216597011579	sensory histidine kinase UhpB; Provisional; Region: PRK11644
216597011580	MASE1; Region: MASE1; pfam05231
216597011581	Histidine kinase; Region: HisKA_3; pfam07730
216597011582	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597011583	ATP binding site [chemical binding]; other site
216597011584	Mg2+ binding site [ion binding]; other site
216597011585	G-X-G motif; other site
216597011586	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
216597011587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597011588	active site
216597011589	phosphorylation site [posttranslational modification]
216597011590	intermolecular recognition site; other site
216597011591	dimerization interface [polypeptide binding]; other site
216597011592	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597011593	DNA binding residues [nucleotide binding]
216597011594	dimerization interface [polypeptide binding]; other site
216597011595	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
216597011596	active site
216597011597	catalytic residues [active]
216597011598	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
216597011599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597011600	putative substrate translocation pore; other site
216597011601	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216597011602	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
216597011603	substrate binding site [chemical binding]; other site
216597011604	dimer interface [polypeptide binding]; other site
216597011605	ATP binding site [chemical binding]; other site
216597011606	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
216597011607	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
216597011608	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216597011609	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
216597011610	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
216597011611	putative valine binding site [chemical binding]; other site
216597011612	dimer interface [polypeptide binding]; other site
216597011613	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
216597011614	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
216597011615	PYR/PP interface [polypeptide binding]; other site
216597011616	dimer interface [polypeptide binding]; other site
216597011617	TPP binding site [chemical binding]; other site
216597011618	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216597011619	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
216597011620	TPP-binding site [chemical binding]; other site
216597011621	dimer interface [polypeptide binding]; other site
216597011622	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
216597011623	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
216597011624	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
216597011625	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597011626	putative substrate translocation pore; other site
216597011627	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
216597011628	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
216597011629	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597011630	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
216597011631	dimerization interface [polypeptide binding]; other site
216597011632	substrate binding pocket [chemical binding]; other site
216597011633	permease DsdX; Provisional; Region: PRK09921
216597011634	gluconate transporter; Region: gntP; TIGR00791
216597011635	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
216597011636	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
216597011637	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216597011638	catalytic residue [active]
216597011639	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
216597011640	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
216597011641	Domain of unknown function (DUF202); Region: DUF202; pfam02656
216597011642	Predicted membrane protein [Function unknown]; Region: COG2149
216597011643	putative transporter; Validated; Region: PRK03818
216597011644	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
216597011645	TrkA-C domain; Region: TrkA_C; pfam02080
216597011646	TrkA-C domain; Region: TrkA_C; pfam02080
216597011647	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
216597011648	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
216597011649	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
216597011650	putative dimer interface [polypeptide binding]; other site
216597011651	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
216597011652	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
216597011653	putative dimer interface [polypeptide binding]; other site
216597011654	hypothetical protein; Provisional; Region: PRK11616
216597011655	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
216597011656	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
216597011657	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
216597011658	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
216597011659	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
216597011660	catalytic residues [active]
216597011661	central insert; other site
216597011662	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
216597011663	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
216597011664	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
216597011665	heme exporter protein CcmC; Region: ccmC; TIGR01191
216597011666	heme exporter protein CcmB; Region: ccmB; TIGR01190
216597011667	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
216597011668	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597011669	Walker A/P-loop; other site
216597011670	ATP binding site [chemical binding]; other site
216597011671	Q-loop/lid; other site
216597011672	ABC transporter signature motif; other site
216597011673	Walker B; other site
216597011674	D-loop; other site
216597011675	H-loop/switch region; other site
216597011676	Haem-binding domain; Region: Haem_bd; pfam14376
216597011677	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
216597011678	chaperone protein TorD; Validated; Region: torD; PRK04976
216597011679	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
216597011680	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
216597011681	molybdopterin cofactor binding site [chemical binding]; other site
216597011682	substrate binding site [chemical binding]; other site
216597011683	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
216597011684	molybdopterin cofactor binding site; other site
216597011685	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
216597011686	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
216597011687	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
216597011688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597011689	active site
216597011690	phosphorylation site [posttranslational modification]
216597011691	intermolecular recognition site; other site
216597011692	dimerization interface [polypeptide binding]; other site
216597011693	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597011694	DNA binding site [nucleotide binding]
216597011695	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
216597011696	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
216597011697	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
216597011698	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597011699	dimer interface [polypeptide binding]; other site
216597011700	phosphorylation site [posttranslational modification]
216597011701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597011702	ATP binding site [chemical binding]; other site
216597011703	Mg2+ binding site [ion binding]; other site
216597011704	G-X-G motif; other site
216597011705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597011706	active site
216597011707	phosphorylation site [posttranslational modification]
216597011708	intermolecular recognition site; other site
216597011709	dimerization interface [polypeptide binding]; other site
216597011710	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216597011711	putative binding surface; other site
216597011712	active site
216597011713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597011714	D-galactonate transporter; Region: 2A0114; TIGR00893
216597011715	putative substrate translocation pore; other site
216597011716	galactonate dehydratase; Provisional; Region: PRK14017
216597011717	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
216597011718	putative active site pocket [active]
216597011719	putative metal binding site [ion binding]; other site
216597011720	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
216597011721	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
216597011722	active site
216597011723	intersubunit interface [polypeptide binding]; other site
216597011724	catalytic residue [active]
216597011725	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
216597011726	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
216597011727	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216597011728	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597011729	DNA-binding site [nucleotide binding]; DNA binding site
216597011730	FCD domain; Region: FCD; pfam07729
216597011731	sugar phosphate phosphatase; Provisional; Region: PRK10513
216597011732	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597011733	active site
216597011734	motif I; other site
216597011735	motif II; other site
216597011736	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597011737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597011738	D-galactonate transporter; Region: 2A0114; TIGR00893
216597011739	putative substrate translocation pore; other site
216597011740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597011741	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
216597011742	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
216597011743	active site pocket [active]
216597011744	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597011745	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597011746	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
216597011747	putative dimerization interface [polypeptide binding]; other site
216597011748	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
216597011749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597011750	Mg2+ binding site [ion binding]; other site
216597011751	G-X-G motif; other site
216597011752	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
216597011753	anchoring element; other site
216597011754	dimer interface [polypeptide binding]; other site
216597011755	ATP binding site [chemical binding]; other site
216597011756	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
216597011757	active site
216597011758	putative metal-binding site [ion binding]; other site
216597011759	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
216597011760	recF protein; Region: recf; TIGR00611
216597011761	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597011762	Walker A/P-loop; other site
216597011763	ATP binding site [chemical binding]; other site
216597011764	Q-loop/lid; other site
216597011765	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597011766	ABC transporter signature motif; other site
216597011767	Walker B; other site
216597011768	D-loop; other site
216597011769	H-loop/switch region; other site
216597011770	DNA polymerase III subunit beta; Validated; Region: PRK05643
216597011771	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
216597011772	putative DNA binding surface [nucleotide binding]; other site
216597011773	dimer interface [polypeptide binding]; other site
216597011774	beta-clamp/clamp loader binding surface; other site
216597011775	beta-clamp/translesion DNA polymerase binding surface; other site
216597011776	DnaA N-terminal domain; Region: DnaA_N; pfam11638
216597011777	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
216597011778	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597011779	Walker A motif; other site
216597011780	ATP binding site [chemical binding]; other site
216597011781	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
216597011782	Walker B motif; other site
216597011783	arginine finger; other site
216597011784	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
216597011785	DnaA box-binding interface [nucleotide binding]; other site
216597011786	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
216597011787	ribonuclease P; Reviewed; Region: rnpA; PRK01732
216597011788	hypothetical protein; Validated; Region: PRK00041
216597011789	membrane protein insertase; Provisional; Region: PRK01318
216597011790	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
216597011791	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
216597011792	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
216597011793	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
216597011794	trmE is a tRNA modification GTPase; Region: trmE; cd04164
216597011795	G1 box; other site
216597011796	GTP/Mg2+ binding site [chemical binding]; other site
216597011797	Switch I region; other site
216597011798	G2 box; other site
216597011799	Switch II region; other site
216597011800	G3 box; other site
216597011801	G4 box; other site
216597011802	G5 box; other site
216597011803	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
216597011805	putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331
216597011806	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
216597011807	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
216597011808	putative active site [active]
216597011809	putative NTP binding site [chemical binding]; other site
216597011810	putative nucleic acid binding site [nucleotide binding]; other site
216597011811	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
216597011812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597011813	putative substrate translocation pore; other site
216597011814	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
216597011815	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597011816	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
216597011817	substrate binding pocket [chemical binding]; other site
216597011818	dimerization interface [polypeptide binding]; other site
216597011819	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
216597011820	Predicted flavoprotein [General function prediction only]; Region: COG0431
216597011821	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
216597011822	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
216597011823	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
216597011824	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597011825	active site
216597011826	motif I; other site
216597011827	motif II; other site
216597011828	transcriptional regulator PhoU; Provisional; Region: PRK11115
216597011829	PhoU domain; Region: PhoU; pfam01895
216597011830	PhoU domain; Region: PhoU; pfam01895
216597011831	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
216597011832	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
216597011833	Walker A/P-loop; other site
216597011834	ATP binding site [chemical binding]; other site
216597011835	Q-loop/lid; other site
216597011836	ABC transporter signature motif; other site
216597011837	Walker B; other site
216597011838	D-loop; other site
216597011839	H-loop/switch region; other site
216597011840	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
216597011841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597011842	dimer interface [polypeptide binding]; other site
216597011843	conserved gate region; other site
216597011844	putative PBP binding loops; other site
216597011845	ABC-ATPase subunit interface; other site
216597011846	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
216597011847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597011848	dimer interface [polypeptide binding]; other site
216597011849	conserved gate region; other site
216597011850	putative PBP binding loops; other site
216597011851	ABC-ATPase subunit interface; other site
216597011852	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597011853	substrate binding pocket [chemical binding]; other site
216597011854	membrane-bound complex binding site; other site
216597011855	hinge residues; other site
216597011856	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
216597011857	active site
216597011858	P-loop; other site
216597011859	phosphorylation site [posttranslational modification]
216597011860	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
216597011861	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
216597011862	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
216597011863	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
216597011864	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
216597011865	shikimate binding site; other site
216597011866	NAD(P) binding site [chemical binding]; other site
216597011867	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
216597011868	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
216597011869	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
216597011870	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
216597011871	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
216597011872	glutaminase active site [active]
216597011873	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
216597011874	dimer interface [polypeptide binding]; other site
216597011875	active site
216597011876	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
216597011877	dimer interface [polypeptide binding]; other site
216597011878	active site
216597011879	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
216597011880	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
216597011881	Substrate binding site; other site
216597011882	Mg++ binding site; other site
216597011883	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
216597011884	active site
216597011885	substrate binding site [chemical binding]; other site
216597011886	CoA binding site [chemical binding]; other site
216597011887	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
216597011888	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
216597011889	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
216597011890	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
216597011891	gamma subunit interface [polypeptide binding]; other site
216597011892	epsilon subunit interface [polypeptide binding]; other site
216597011893	LBP interface [polypeptide binding]; other site
216597011894	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
216597011895	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
216597011896	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
216597011897	alpha subunit interaction interface [polypeptide binding]; other site
216597011898	Walker A motif; other site
216597011899	ATP binding site [chemical binding]; other site
216597011900	Walker B motif; other site
216597011901	inhibitor binding site; inhibition site
216597011902	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
216597011903	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
216597011904	core domain interface [polypeptide binding]; other site
216597011905	delta subunit interface [polypeptide binding]; other site
216597011906	epsilon subunit interface [polypeptide binding]; other site
216597011907	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
216597011908	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
216597011909	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
216597011910	beta subunit interaction interface [polypeptide binding]; other site
216597011911	Walker A motif; other site
216597011912	ATP binding site [chemical binding]; other site
216597011913	Walker B motif; other site
216597011914	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
216597011915	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
216597011916	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
216597011917	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
216597011918	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
216597011919	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
216597011920	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
216597011921	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
216597011922	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
216597011923	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
216597011924	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597011925	S-adenosylmethionine binding site [chemical binding]; other site
216597011926	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
216597011927	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
216597011928	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
216597011929	FMN-binding protein MioC; Provisional; Region: PRK09004
216597011930	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
216597011931	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216597011932	putative DNA binding site [nucleotide binding]; other site
216597011933	putative Zn2+ binding site [ion binding]; other site
216597011934	AsnC family; Region: AsnC_trans_reg; pfam01037
216597011935	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
216597011936	dimer interface [polypeptide binding]; other site
216597011937	active site
216597011938	hypothetical protein; Provisional; Region: yieM; PRK10997
216597011939	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
216597011940	metal ion-dependent adhesion site (MIDAS); other site
216597011941	regulatory ATPase RavA; Provisional; Region: PRK13531
216597011942	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597011943	Walker A motif; other site
216597011944	ATP binding site [chemical binding]; other site
216597011945	Walker B motif; other site
216597011946	arginine finger; other site
216597011947	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
216597011948	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
216597011949	potassium uptake protein; Region: kup; TIGR00794
216597011950	D-ribose pyranase; Provisional; Region: PRK11797
216597011951	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
216597011952	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
216597011953	Walker A/P-loop; other site
216597011954	ATP binding site [chemical binding]; other site
216597011955	Q-loop/lid; other site
216597011956	ABC transporter signature motif; other site
216597011957	Walker B; other site
216597011958	D-loop; other site
216597011959	H-loop/switch region; other site
216597011960	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
216597011961	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216597011962	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216597011963	TM-ABC transporter signature motif; other site
216597011964	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
216597011965	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
216597011966	ligand binding site [chemical binding]; other site
216597011967	dimerization interface [polypeptide binding]; other site
216597011968	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216597011969	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
216597011970	substrate binding site [chemical binding]; other site
216597011971	dimer interface [polypeptide binding]; other site
216597011972	ATP binding site [chemical binding]; other site
216597011973	transcriptional repressor RbsR; Provisional; Region: PRK10423
216597011974	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597011975	DNA binding site [nucleotide binding]
216597011976	domain linker motif; other site
216597011977	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
216597011978	dimerization interface [polypeptide binding]; other site
216597011979	ligand binding site [chemical binding]; other site
216597011981	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216597011982	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597011983	DNA-binding site [nucleotide binding]; DNA binding site
216597011984	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216597011985	transcriptional regulator HdfR; Provisional; Region: PRK03601
216597011986	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597011987	LysR substrate binding domain; Region: LysR_substrate; pfam03466
216597011988	dimerization interface [polypeptide binding]; other site
216597011989	hypothetical protein; Provisional; Region: PRK11027
216597011990	putative ATP-dependent protease; Provisional; Region: PRK09862
216597011991	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
216597011992	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597011993	Walker A motif; other site
216597011994	ATP binding site [chemical binding]; other site
216597011995	Walker B motif; other site
216597011996	arginine finger; other site
216597011997	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
216597011998	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
216597011999	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
216597012000	PYR/PP interface [polypeptide binding]; other site
216597012001	dimer interface [polypeptide binding]; other site
216597012002	TPP binding site [chemical binding]; other site
216597012003	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216597012004	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
216597012005	TPP-binding site [chemical binding]; other site
216597012006	dimer interface [polypeptide binding]; other site
216597012007	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
216597012008	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
216597012009	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
216597012010	homodimer interface [polypeptide binding]; other site
216597012011	substrate-cofactor binding pocket; other site
216597012012	catalytic residue [active]
216597012013	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
216597012014	threonine dehydratase; Reviewed; Region: PRK09224
216597012015	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
216597012016	tetramer interface [polypeptide binding]; other site
216597012017	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597012018	catalytic residue [active]
216597012019	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
216597012020	putative Ile/Val binding site [chemical binding]; other site
216597012021	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
216597012022	putative Ile/Val binding site [chemical binding]; other site
216597012023	Phage-related protein [Function unknown]; Region: COG4679
216597012024	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
216597012025	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597012026	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
216597012027	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
216597012028	putative dimerization interface [polypeptide binding]; other site
216597012029	ketol-acid reductoisomerase; Validated; Region: PRK05225
216597012030	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
216597012031	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
216597012032	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
216597012033	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
216597012034	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
216597012037	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
216597012038	Part of AAA domain; Region: AAA_19; pfam13245
216597012039	Family description; Region: UvrD_C_2; pfam13538
216597012040	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
216597012041	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
216597012042	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
216597012043	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
216597012044	ATP binding site [chemical binding]; other site
216597012045	Mg++ binding site [ion binding]; other site
216597012046	motif III; other site
216597012047	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597012048	nucleotide binding region [chemical binding]; other site
216597012049	ATP-binding site [chemical binding]; other site
216597012050	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
216597012051	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
216597012052	catalytic residues [active]
216597012053	transcription termination factor Rho; Provisional; Region: rho; PRK09376
216597012054	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
216597012055	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
216597012056	RNA binding site [nucleotide binding]; other site
216597012057	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
216597012058	multimer interface [polypeptide binding]; other site
216597012059	Walker A motif; other site
216597012060	ATP binding site [chemical binding]; other site
216597012061	Walker B motif; other site
216597012062	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
216597012063	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
216597012064	Mg++ binding site [ion binding]; other site
216597012065	putative catalytic motif [active]
216597012066	substrate binding site [chemical binding]; other site
216597012067	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
216597012068	Chain length determinant protein; Region: Wzz; pfam02706
216597012069	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
216597012070	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
216597012071	active site
216597012072	homodimer interface [polypeptide binding]; other site
216597012073	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
216597012074	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
216597012075	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
216597012076	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
216597012077	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
216597012078	NAD binding site [chemical binding]; other site
216597012079	substrate binding site [chemical binding]; other site
216597012080	homodimer interface [polypeptide binding]; other site
216597012081	active site
216597012082	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
216597012083	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216597012084	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
216597012085	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
216597012086	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
216597012087	inhibitor-cofactor binding pocket; inhibition site
216597012088	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597012089	catalytic residue [active]
216597012090	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
216597012091	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
216597012092	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
216597012093	putative common antigen polymerase; Provisional; Region: PRK02975
216597012094	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
216597012095	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
216597012096	putative transport protein YifK; Provisional; Region: PRK10746
216597012097	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
216597012098	HemY protein N-terminus; Region: HemY_N; pfam07219
216597012099	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
216597012100	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
216597012101	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
216597012102	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
216597012103	active site
216597012104	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
216597012105	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
216597012106	domain interfaces; other site
216597012107	active site
216597012108	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
216597012109	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
216597012110	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
216597012111	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
216597012112	putative iron binding site [ion binding]; other site
216597012113	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
216597012115	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
216597012116	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
216597012117	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
216597012118	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
216597012119	hypothetical protein; Provisional; Region: PRK10963
216597012120	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
216597012121	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
216597012122	active site
216597012123	Int/Topo IB signature motif; other site
216597012124	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
216597012125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597012126	motif II; other site
216597012127	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
216597012128	Part of AAA domain; Region: AAA_19; pfam13245
216597012129	Family description; Region: UvrD_C_2; pfam13538
216597012130	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
216597012131	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
216597012132	Cl binding site [ion binding]; other site
216597012133	oligomer interface [polypeptide binding]; other site
216597012134	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
216597012135	hypothetical protein; Provisional; Region: PRK11371
216597012136	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
216597012137	EamA-like transporter family; Region: EamA; cl17759
216597012138	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
216597012139	CoenzymeA binding site [chemical binding]; other site
216597012140	subunit interaction site [polypeptide binding]; other site
216597012141	PHB binding site; other site
216597012142	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
216597012143	dimerization interface [polypeptide binding]; other site
216597012144	substrate binding site [chemical binding]; other site
216597012145	active site
216597012146	calcium binding site [ion binding]; other site
216597012147	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
216597012148	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216597012149	ATP binding site [chemical binding]; other site
216597012150	putative Mg++ binding site [ion binding]; other site
216597012151	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216597012152	nucleotide binding region [chemical binding]; other site
216597012153	ATP-binding site [chemical binding]; other site
216597012154	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
216597012155	Helicase and RNase D C-terminal; Region: HRDC; smart00341
216597012156	threonine efflux system; Provisional; Region: PRK10229
216597012157	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
216597012158	lysophospholipase L2; Provisional; Region: PRK10749
216597012159	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216597012160	putative hydrolase; Provisional; Region: PRK10976
216597012161	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597012162	active site
216597012163	motif I; other site
216597012164	motif II; other site
216597012165	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597012166	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
216597012167	EamA-like transporter family; Region: EamA; pfam00892
216597012168	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
216597012169	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597012170	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
216597012171	putative dimerization interface [polypeptide binding]; other site
216597012172	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
216597012173	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
216597012174	THF binding site; other site
216597012175	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
216597012176	substrate binding site [chemical binding]; other site
216597012177	THF binding site; other site
216597012178	zinc-binding site [ion binding]; other site
216597012179	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
216597012180	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597012181	FeS/SAM binding site; other site
216597012182	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
216597012183	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
216597012184	uridine phosphorylase; Provisional; Region: PRK11178
216597012185	uridine phosphorylase; Region: Uridine-psphlse; TIGR01718
216597012186	DNA recombination protein RmuC; Provisional; Region: PRK10361
216597012187	RmuC family; Region: RmuC; pfam02646
216597012188	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
216597012189	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597012190	S-adenosylmethionine binding site [chemical binding]; other site
216597012191	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
216597012192	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
216597012193	SCP-2 sterol transfer family; Region: SCP2; pfam02036
216597012194	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
216597012195	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
216597012196	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
216597012197	sec-independent translocase; Provisional; Region: PRK01770
216597012198	sec-independent translocase; Provisional; Region: tatB; PRK00404
216597012199	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
216597012200	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
216597012201	active site
216597012202	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
216597012203	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
216597012204	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
216597012205	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
216597012206	FMN reductase; Validated; Region: fre; PRK08051
216597012207	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
216597012208	FAD binding pocket [chemical binding]; other site
216597012209	FAD binding motif [chemical binding]; other site
216597012210	phosphate binding motif [ion binding]; other site
216597012211	beta-alpha-beta structure motif; other site
216597012212	NAD binding pocket [chemical binding]; other site
216597012213	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
216597012214	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
216597012215	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
216597012216	dimer interface [polypeptide binding]; other site
216597012217	active site
216597012218	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
216597012219	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216597012220	substrate binding site [chemical binding]; other site
216597012221	oxyanion hole (OAH) forming residues; other site
216597012222	trimer interface [polypeptide binding]; other site
216597012223	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
216597012224	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
216597012225	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
216597012226	proline dipeptidase; Provisional; Region: PRK13607
216597012227	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
216597012228	active site
216597012229	hypothetical protein; Provisional; Region: PRK11568
216597012230	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
216597012231	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
216597012232	potassium transporter; Provisional; Region: PRK10750
216597012233	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
216597012234	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
216597012235	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
216597012236	Walker A motif; other site
216597012237	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
216597012238	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
216597012239	GTP binding site; other site
216597012240	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
216597012241	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
216597012242	serine/threonine protein kinase; Provisional; Region: PRK11768
216597012243	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
216597012244	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
216597012245	catalytic residues [active]
216597012246	hinge region; other site
216597012247	alpha helical domain; other site
216597012248	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
216597012249	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
216597012250	putative acyl-acceptor binding pocket; other site
216597012251	DNA polymerase I; Provisional; Region: PRK05755
216597012252	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
216597012253	active site
216597012254	metal binding site 1 [ion binding]; metal-binding site
216597012255	putative 5' ssDNA interaction site; other site
216597012256	metal binding site 3; metal-binding site
216597012257	metal binding site 2 [ion binding]; metal-binding site
216597012258	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
216597012259	putative DNA binding site [nucleotide binding]; other site
216597012260	putative metal binding site [ion binding]; other site
216597012261	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
216597012262	active site
216597012263	catalytic site [active]
216597012264	substrate binding site [chemical binding]; other site
216597012265	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
216597012266	active site
216597012267	DNA binding site [nucleotide binding]
216597012268	catalytic site [active]
216597012269	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
216597012270	G1 box; other site
216597012271	GTP/Mg2+ binding site [chemical binding]; other site
216597012272	Switch I region; other site
216597012273	G2 box; other site
216597012274	G3 box; other site
216597012275	Switch II region; other site
216597012276	G4 box; other site
216597012277	G5 box; other site
216597012278	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
216597012279	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
216597012280	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597012281	FeS/SAM binding site; other site
216597012282	HemN C-terminal domain; Region: HemN_C; pfam06969
216597012283	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
216597012284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597012285	active site
216597012286	phosphorylation site [posttranslational modification]
216597012287	intermolecular recognition site; other site
216597012288	dimerization interface [polypeptide binding]; other site
216597012289	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597012290	Walker A motif; other site
216597012291	ATP binding site [chemical binding]; other site
216597012292	Walker B motif; other site
216597012293	arginine finger; other site
216597012294	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216597012295	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
216597012296	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216597012297	putative active site [active]
216597012298	heme pocket [chemical binding]; other site
216597012299	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597012300	dimer interface [polypeptide binding]; other site
216597012301	phosphorylation site [posttranslational modification]
216597012302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597012303	ATP binding site [chemical binding]; other site
216597012304	Mg2+ binding site [ion binding]; other site
216597012305	G-X-G motif; other site
216597012306	glutamine synthetase; Provisional; Region: glnA; PRK09469
216597012307	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
216597012308	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
216597012309	GTP-binding protein; Provisional; Region: PRK10218
216597012310	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
216597012311	G1 box; other site
216597012312	putative GEF interaction site [polypeptide binding]; other site
216597012313	GTP/Mg2+ binding site [chemical binding]; other site
216597012314	Switch I region; other site
216597012315	G2 box; other site
216597012316	G3 box; other site
216597012317	Switch II region; other site
216597012318	G4 box; other site
216597012319	G5 box; other site
216597012320	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
216597012321	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
216597012322	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597012323	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
216597012324	active site
216597012325	motif I; other site
216597012326	motif II; other site
216597012327	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597012328	coproporphyrinogen III oxidase; Validated; Region: PRK08208
216597012329	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597012330	FeS/SAM binding site; other site
216597012331	HemN C-terminal domain; Region: HemN_C; pfam06969
216597012332	Sulfatase; Region: Sulfatase; cl17466
216597012333	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
216597012334	outer membrane porin L; Provisional; Region: ompL; PRK09980
216597012335	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
216597012336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597012337	putative substrate translocation pore; other site
216597012338	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
216597012339	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
216597012340	alpha-glucosidase; Provisional; Region: PRK10426
216597012341	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
216597012342	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
216597012343	putative active site [active]
216597012344	putative catalytic site [active]
216597012345	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
216597012346	active site
216597012347	catalytic residues [active]
216597012348	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
216597012349	dimerization interface [polypeptide binding]; other site
216597012350	putative active cleft [active]
216597012351	Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684
216597012352	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
216597012353	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
216597012354	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216597012355	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
216597012356	substrate binding site [chemical binding]; other site
216597012357	ATP binding site [chemical binding]; other site
216597012358	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
216597012359	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216597012360	putative DNA binding site [nucleotide binding]; other site
216597012361	putative Zn2+ binding site [ion binding]; other site
216597012362	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216597012363	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
216597012364	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597012365	motif II; other site
216597012366	hypothetical protein; Reviewed; Region: PRK01637
216597012367	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
216597012368	putative active site [active]
216597012369	dimerization interface [polypeptide binding]; other site
216597012370	putative tRNAtyr binding site [nucleotide binding]; other site
216597012371	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597012372	Coenzyme A binding pocket [chemical binding]; other site
216597012373	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
216597012374	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597012375	non-specific DNA binding site [nucleotide binding]; other site
216597012376	salt bridge; other site
216597012377	sequence-specific DNA binding site [nucleotide binding]; other site
216597012378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
216597012379	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
216597012380	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
216597012381	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
216597012382	Predicted transcriptional regulator [Transcription]; Region: COG2944
216597012383	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597012384	non-specific DNA binding site [nucleotide binding]; other site
216597012385	salt bridge; other site
216597012386	sequence-specific DNA binding site [nucleotide binding]; other site
216597012387	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
216597012388	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
216597012389	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
216597012390	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
216597012391	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
216597012392	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
216597012393	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
216597012394	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
216597012395	[4Fe-4S] binding site [ion binding]; other site
216597012396	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
216597012397	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
216597012398	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
216597012399	molybdopterin cofactor binding site; other site
216597012400	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
216597012401	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
216597012402	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
216597012403	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
216597012404	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
216597012405	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216597012406	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597012407	non-specific DNA binding site [nucleotide binding]; other site
216597012408	salt bridge; other site
216597012409	sequence-specific DNA binding site [nucleotide binding]; other site
216597012410	Cupin domain; Region: Cupin_2; cl17218
216597012411	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
216597012412	lactaldehyde reductase; Region: lactal_redase; TIGR02638
216597012413	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
216597012414	dimer interface [polypeptide binding]; other site
216597012415	active site
216597012416	metal binding site [ion binding]; metal-binding site
216597012417	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
216597012418	intersubunit interface [polypeptide binding]; other site
216597012419	active site
216597012420	Zn2+ binding site [ion binding]; other site
216597012421	L-rhamnose isomerase; Provisional; Region: PRK01076
216597012422	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
216597012423	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
216597012424	N- and C-terminal domain interface [polypeptide binding]; other site
216597012425	active site
216597012426	putative catalytic site [active]
216597012427	metal binding site [ion binding]; metal-binding site
216597012428	ATP binding site [chemical binding]; other site
216597012429	rhamnulokinase; Provisional; Region: rhaB; PRK10640
216597012430	carbohydrate binding site [chemical binding]; other site
216597012431	transcriptional activator RhaS; Provisional; Region: PRK13503
216597012432	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216597012433	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597012434	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597012435	transcriptional activator RhaR; Provisional; Region: PRK13502
216597012436	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216597012437	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597012438	L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379
216597012439	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
216597012440	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
216597012441	DctM-like transporters; Region: DctM; pfam06808
216597012442	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
216597012443	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
216597012444	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
216597012445	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
216597012446	superoxide dismutase; Provisional; Region: PRK10925
216597012447	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
216597012448	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
216597012449	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
216597012450	MOSC domain; Region: MOSC; pfam03473
216597012451	3-alpha domain; Region: 3-alpha; pfam03475
216597012452	SnoaL-like domain; Region: SnoaL_2; pfam12680
216597012453	two-component sensor protein; Provisional; Region: cpxA; PRK09470
216597012454	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597012455	dimerization interface [polypeptide binding]; other site
216597012456	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597012457	dimer interface [polypeptide binding]; other site
216597012458	phosphorylation site [posttranslational modification]
216597012459	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597012460	ATP binding site [chemical binding]; other site
216597012461	Mg2+ binding site [ion binding]; other site
216597012462	G-X-G motif; other site
216597012463	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
216597012464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597012465	active site
216597012466	intermolecular recognition site; other site
216597012467	dimerization interface [polypeptide binding]; other site
216597012468	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597012469	DNA binding site [nucleotide binding]
216597012470	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
216597012471	dimer interface [polypeptide binding]; other site
216597012472	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
216597012473	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
216597012474	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
216597012475	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
216597012476	active site
216597012477	ADP/pyrophosphate binding site [chemical binding]; other site
216597012478	dimerization interface [polypeptide binding]; other site
216597012479	allosteric effector site; other site
216597012480	fructose-1,6-bisphosphate binding site; other site
216597012481	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
216597012482	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597012483	substrate binding pocket [chemical binding]; other site
216597012484	membrane-bound complex binding site; other site
216597012485	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
216597012486	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
216597012487	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
216597012488	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216597012489	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
216597012490	putative substrate binding site [chemical binding]; other site
216597012491	putative ATP binding site [chemical binding]; other site
216597012492	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
216597012493	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
216597012494	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597012495	DNA-binding site [nucleotide binding]; DNA binding site
216597012496	Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293
216597012497	UTRA domain; Region: UTRA; pfam07702
216597012499	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
216597012500	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
216597012501	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
216597012502	putative N- and C-terminal domain interface [polypeptide binding]; other site
216597012503	putative active site [active]
216597012504	putative MgATP binding site [chemical binding]; other site
216597012505	catalytic site [active]
216597012506	metal binding site [ion binding]; metal-binding site
216597012507	putative carbohydrate binding site [chemical binding]; other site
216597012508	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
216597012509	transcriptional regulator LsrR; Provisional; Region: PRK15418
216597012510	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
216597012511	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
216597012512	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
216597012513	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
216597012514	Walker A/P-loop; other site
216597012515	ATP binding site [chemical binding]; other site
216597012516	Q-loop/lid; other site
216597012517	ABC transporter signature motif; other site
216597012518	Walker B; other site
216597012519	D-loop; other site
216597012520	H-loop/switch region; other site
216597012521	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
216597012522	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216597012523	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216597012524	TM-ABC transporter signature motif; other site
216597012525	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216597012526	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216597012527	TM-ABC transporter signature motif; other site
216597012528	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
216597012529	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
216597012530	ligand binding site [chemical binding]; other site
216597012531	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
216597012532	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
216597012533	putative active site; other site
216597012534	catalytic residue [active]
216597012535	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
216597012536	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
216597012537	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
216597012538	substrate binding site [chemical binding]; other site
216597012539	hexamer interface [polypeptide binding]; other site
216597012540	metal binding site [ion binding]; metal-binding site
216597012541	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
216597012542	triosephosphate isomerase; Provisional; Region: PRK14567
216597012543	substrate binding site [chemical binding]; other site
216597012544	dimer interface [polypeptide binding]; other site
216597012545	catalytic triad [active]
216597012546	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
216597012547	Predicted membrane protein [Function unknown]; Region: COG3152
216597012548	ferredoxin-NADP reductase; Provisional; Region: PRK10926
216597012549	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
216597012550	FAD binding pocket [chemical binding]; other site
216597012551	FAD binding motif [chemical binding]; other site
216597012552	phosphate binding motif [ion binding]; other site
216597012553	beta-alpha-beta structure motif; other site
216597012554	NAD binding pocket [chemical binding]; other site
216597012555	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
216597012556	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
216597012557	putative active site [active]
216597012558	glycerol kinase; Provisional; Region: glpK; PRK00047
216597012559	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
216597012560	N- and C-terminal domain interface [polypeptide binding]; other site
216597012561	active site
216597012562	MgATP binding site [chemical binding]; other site
216597012563	catalytic site [active]
216597012564	metal binding site [ion binding]; metal-binding site
216597012565	glycerol binding site [chemical binding]; other site
216597012566	homotetramer interface [polypeptide binding]; other site
216597012567	homodimer interface [polypeptide binding]; other site
216597012568	FBP binding site [chemical binding]; other site
216597012569	protein IIAGlc interface [polypeptide binding]; other site
216597012570	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
216597012571	amphipathic channel; other site
216597012572	Asn-Pro-Ala signature motifs; other site
216597012573	septal ring assembly protein ZapB; Provisional; Region: PRK15422
216597012574	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
216597012575	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
216597012576	UbiA prenyltransferase family; Region: UbiA; pfam01040
216597012577	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
216597012578	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597012579	Walker A motif; other site
216597012580	ATP binding site [chemical binding]; other site
216597012581	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
216597012582	Walker B motif; other site
216597012583	arginine finger; other site
216597012584	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
216597012585	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
216597012586	active site
216597012587	HslU subunit interaction site [polypeptide binding]; other site
216597012588	essential cell division protein FtsN; Provisional; Region: PRK10927
216597012589	cell division protein FtsN; Provisional; Region: PRK12757
216597012590	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597012591	DNA binding site [nucleotide binding]
216597012592	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
216597012593	domain linker motif; other site
216597012594	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
216597012595	dimerization interface [polypeptide binding]; other site
216597012596	ligand binding site [chemical binding]; other site
216597012597	primosome assembly protein PriA; Validated; Region: PRK05580
216597012598	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216597012599	ATP binding site [chemical binding]; other site
216597012600	putative Mg++ binding site [ion binding]; other site
216597012601	helicase superfamily c-terminal domain; Region: HELICc; smart00490
216597012602	ATP-binding site [chemical binding]; other site
216597012603	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
216597012604	conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117
216597012605	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
216597012606	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
216597012607	dimerization interface [polypeptide binding]; other site
216597012608	DNA binding site [nucleotide binding]
216597012609	corepressor binding sites; other site
216597012610	cystathionine gamma-synthase; Provisional; Region: PRK08045
216597012611	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
216597012612	homodimer interface [polypeptide binding]; other site
216597012613	substrate-cofactor binding pocket; other site
216597012614	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597012615	catalytic residue [active]
216597012616	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
216597012617	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
216597012618	putative catalytic residues [active]
216597012619	putative nucleotide binding site [chemical binding]; other site
216597012620	putative aspartate binding site [chemical binding]; other site
216597012621	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
216597012622	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
216597012623	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
216597012624	Conserved TM helix; Region: TM_helix; pfam05552
216597012625	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216597012626	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
216597012627	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
216597012628	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
216597012629	active site
216597012630	metal binding site [ion binding]; metal-binding site
216597012631	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
216597012632	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
216597012633	FAD binding site [chemical binding]; other site
216597012634	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
216597012635	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
216597012636	heme binding site [chemical binding]; other site
216597012637	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
216597012638	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738
216597012639	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
216597012640	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
216597012641	dimer interface [polypeptide binding]; other site
216597012642	active site
216597012643	metal binding site [ion binding]; metal-binding site
216597012644	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
216597012645	active site
216597012646	intersubunit interactions; other site
216597012647	catalytic residue [active]
216597012648	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
216597012649	dimerization domain swap beta strand [polypeptide binding]; other site
216597012650	regulatory protein interface [polypeptide binding]; other site
216597012651	active site
216597012652	regulatory phosphorylation site [posttranslational modification]; other site
216597012653	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
216597012654	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
216597012655	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
216597012656	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
216597012657	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216597012658	active site
216597012659	phosphorylation site [posttranslational modification]
216597012660	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
216597012661	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
216597012662	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
216597012663	active site
216597012664	P-loop; other site
216597012665	phosphorylation site [posttranslational modification]
216597012666	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
216597012667	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
216597012668	dimer interface [polypeptide binding]; other site
216597012669	active site
216597012670	glycine loop; other site
216597012671	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597012672	FeS/SAM binding site; other site
216597012673	pyruvate formate lyase II activase; Provisional; Region: PRK10076
216597012674	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
216597012675	active site
216597012676	P-loop; other site
216597012677	phosphorylation site [posttranslational modification]
216597012678	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216597012679	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597012680	hypothetical protein; Provisional; Region: PRK10649
216597012681	Sulfatase; Region: Sulfatase; pfam00884
216597012682	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
216597012683	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
216597012684	acetylornithine deacetylase; Provisional; Region: PRK05111
216597012685	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
216597012686	metal binding site [ion binding]; metal-binding site
216597012687	putative dimer interface [polypeptide binding]; other site
216597012688	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
216597012689	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
216597012690	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
216597012691	nucleotide binding site [chemical binding]; other site
216597012692	N-acetyl-L-glutamate binding site [chemical binding]; other site
216597012693	argininosuccinate lyase; Provisional; Region: PRK04833
216597012694	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
216597012695	active sites [active]
216597012696	tetramer interface [polypeptide binding]; other site
216597012697	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
216597012698	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597012699	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
216597012700	dimerization interface [polypeptide binding]; other site
216597012701	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
216597012702	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216597012703	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
216597012704	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
216597012705	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597012706	hypothetical protein; Provisional; Region: PRK11056
216597012707	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
216597012708	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
216597012709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597012710	S-adenosylmethionine binding site [chemical binding]; other site
216597012711	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
216597012712	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216597012713	N-terminal plug; other site
216597012714	ligand-binding site [chemical binding]; other site
216597012715	glutamate racemase; Provisional; Region: PRK00865
216597012716	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
216597012717	FAD binding domain; Region: FAD_binding_4; pfam01565
216597012718	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
216597012719	Biotin operon repressor [Transcription]; Region: BirA; COG1654
216597012720	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
216597012721	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
216597012722	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
216597012723	pantothenate kinase; Provisional; Region: PRK05439
216597012724	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
216597012725	ATP-binding site [chemical binding]; other site
216597012726	CoA-binding site [chemical binding]; other site
216597012727	Mg2+-binding site [ion binding]; other site
216597012728	elongation factor Tu; Reviewed; Region: PRK00049
216597012729	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
216597012730	G1 box; other site
216597012731	GEF interaction site [polypeptide binding]; other site
216597012732	GTP/Mg2+ binding site [chemical binding]; other site
216597012733	Switch I region; other site
216597012734	G2 box; other site
216597012735	G3 box; other site
216597012736	Switch II region; other site
216597012737	G4 box; other site
216597012738	G5 box; other site
216597012739	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
216597012740	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
216597012741	Antibiotic Binding Site [chemical binding]; other site
216597012742	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
216597012743	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
216597012744	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
216597012745	putative homodimer interface [polypeptide binding]; other site
216597012746	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
216597012747	heterodimer interface [polypeptide binding]; other site
216597012748	homodimer interface [polypeptide binding]; other site
216597012749	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
216597012750	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
216597012751	23S rRNA interface [nucleotide binding]; other site
216597012752	L7/L12 interface [polypeptide binding]; other site
216597012753	putative thiostrepton binding site; other site
216597012754	L25 interface [polypeptide binding]; other site
216597012755	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
216597012756	mRNA/rRNA interface [nucleotide binding]; other site
216597012757	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
216597012758	23S rRNA interface [nucleotide binding]; other site
216597012759	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
216597012760	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
216597012761	core dimer interface [polypeptide binding]; other site
216597012762	peripheral dimer interface [polypeptide binding]; other site
216597012763	L10 interface [polypeptide binding]; other site
216597012764	L11 interface [polypeptide binding]; other site
216597012765	putative EF-Tu interaction site [polypeptide binding]; other site
216597012766	putative EF-G interaction site [polypeptide binding]; other site
216597012767	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
216597012768	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
216597012769	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
216597012770	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
216597012771	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
216597012772	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
216597012773	RPB3 interaction site [polypeptide binding]; other site
216597012774	RPB1 interaction site [polypeptide binding]; other site
216597012775	RPB11 interaction site [polypeptide binding]; other site
216597012776	RPB10 interaction site [polypeptide binding]; other site
216597012777	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
216597012778	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
216597012779	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
216597012780	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
216597012781	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
216597012782	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
216597012783	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
216597012784	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
216597012785	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
216597012786	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
216597012787	DNA binding site [nucleotide binding]
216597012788	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
216597012789	type III secretion system protein; Provisional; Region: PRK15384
216597012790	non-LEE encoded effector protein NleB; Provisional; Region: PRK15382
216597012791	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
216597012792	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597012793	FeS/SAM binding site; other site
216597012794	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
216597012795	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
216597012796	ThiS interaction site; other site
216597012797	putative active site [active]
216597012798	tetramer interface [polypeptide binding]; other site
216597012799	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
216597012800	thiS-thiF/thiG interaction site; other site
216597012801	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
216597012802	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
216597012803	ATP binding site [chemical binding]; other site
216597012804	substrate interface [chemical binding]; other site
216597012805	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
216597012806	thiamine phosphate binding site [chemical binding]; other site
216597012807	active site
216597012808	pyrophosphate binding site [ion binding]; other site
216597012809	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
216597012810	ThiC-associated domain; Region: ThiC-associated; pfam13667
216597012811	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
216597012812	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
216597012813	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
216597012814	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
216597012815	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
216597012816	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
216597012817	putative NADH binding site [chemical binding]; other site
216597012818	putative active site [active]
216597012819	nudix motif; other site
216597012820	putative metal binding site [ion binding]; other site
216597012821	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
216597012822	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
216597012823	substrate binding site [chemical binding]; other site
216597012824	active site
216597012825	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
216597012826	Active_site [active]
216597012827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
216597012828	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
216597012829	IHF dimer interface [polypeptide binding]; other site
216597012830	IHF - DNA interface [nucleotide binding]; other site
216597012831	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
216597012832	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
216597012833	dimer interface [polypeptide binding]; other site
216597012834	sensor protein ZraS; Provisional; Region: PRK10364
216597012835	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597012836	dimer interface [polypeptide binding]; other site
216597012837	phosphorylation site [posttranslational modification]
216597012838	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597012839	ATP binding site [chemical binding]; other site
216597012840	Mg2+ binding site [ion binding]; other site
216597012841	G-X-G motif; other site
216597012842	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
216597012843	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597012844	active site
216597012845	phosphorylation site [posttranslational modification]
216597012846	intermolecular recognition site; other site
216597012847	dimerization interface [polypeptide binding]; other site
216597012848	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597012849	Walker A motif; other site
216597012850	ATP binding site [chemical binding]; other site
216597012851	Walker B motif; other site
216597012852	arginine finger; other site
216597012853	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216597012854	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
216597012855	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
216597012856	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
216597012857	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
216597012858	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
216597012859	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
216597012860	purine monophosphate binding site [chemical binding]; other site
216597012861	dimer interface [polypeptide binding]; other site
216597012862	putative catalytic residues [active]
216597012863	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
216597012864	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
216597012865	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597012866	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
216597012867	Coenzyme A binding pocket [chemical binding]; other site
216597012868	homoserine O-succinyltransferase; Provisional; Region: PRK05368
216597012869	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
216597012870	proposed active site lysine [active]
216597012871	conserved cys residue [active]
216597012872	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
216597012873	malate synthase A; Region: malate_syn_A; TIGR01344
216597012874	active site
216597012875	isocitrate lyase; Provisional; Region: PRK15063
216597012876	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
216597012877	tetramer interface [polypeptide binding]; other site
216597012878	active site
216597012879	Mg2+/Mn2+ binding site [ion binding]; other site
216597012880	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
216597012881	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
216597012882	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
216597012883	transcriptional repressor IclR; Provisional; Region: PRK11569
216597012884	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
216597012885	Bacterial transcriptional regulator; Region: IclR; pfam01614
216597012886	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
216597012887	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
216597012888	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
216597012889	substrate binding pocket [chemical binding]; other site
216597012890	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
216597012891	B12 binding site [chemical binding]; other site
216597012892	cobalt ligand [ion binding]; other site
216597012893	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
216597012894	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
216597012895	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
216597012896	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
216597012897	active site pocket [active]
216597012898	oxyanion hole [active]
216597012899	catalytic triad [active]
216597012900	active site nucleophile [active]
216597012901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
216597012902	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
216597012903	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216597012904	RNA binding surface [nucleotide binding]; other site
216597012905	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
216597012906	probable active site [active]
216597012907	hypothetical protein; Provisional; Region: PRK10515
216597012908	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
216597012909	Sodium Bile acid symporter family; Region: SBF; pfam01758
216597012910	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
216597012911	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
216597012912	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
216597012913	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
216597012914	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
216597012915	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
216597012916	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
216597012917	Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948
216597012918	Phage baseplate assembly protein W [General function prediction only]; Region: COG3628
216597012919	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
216597012920	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
216597012921	Ligand binding site; other site
216597012922	Putative Catalytic site; other site
216597012923	DXD motif; other site
216597012924	Predicted membrane protein [Function unknown]; Region: COG2246
216597012925	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
216597012926	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
216597012927	Phage protein D [General function prediction only]; Region: COG3500
216597012928	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
216597012929	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
216597012930	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
216597012931	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
216597012932	Phage tail tube protein FII [General function prediction only]; Region: COG3498
216597012933	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
216597012934	Gp37 protein; Region: Gp37; pfam09646
216597012935	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
216597012936	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216597012937	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216597012938	catalytic residue [active]
216597012939	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
216597012940	Mor transcription activator family; Region: Mor; pfam08765
216597012941	aspartate kinase III; Validated; Region: PRK09084
216597012942	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
216597012943	nucleotide binding site [chemical binding]; other site
216597012944	substrate binding site [chemical binding]; other site
216597012945	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
216597012946	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
216597012947	dimer interface [polypeptide binding]; other site
216597012948	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
216597012949	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
216597012950	active site
216597012951	dimer interface [polypeptide binding]; other site
216597012952	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
216597012953	dimer interface [polypeptide binding]; other site
216597012954	active site
216597012955	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
216597012956	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
216597012957	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
216597012958	Predicted membrane protein [Function unknown]; Region: COG3223
216597012959	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
216597012960	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597012961	dimer interface [polypeptide binding]; other site
216597012962	conserved gate region; other site
216597012963	putative PBP binding loops; other site
216597012964	ABC-ATPase subunit interface; other site
216597012965	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216597012966	dimer interface [polypeptide binding]; other site
216597012967	conserved gate region; other site
216597012968	putative PBP binding loops; other site
216597012969	ABC-ATPase subunit interface; other site
216597012970	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
216597012971	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
216597012972	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
216597012973	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
216597012974	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
216597012975	Walker A/P-loop; other site
216597012976	ATP binding site [chemical binding]; other site
216597012977	Q-loop/lid; other site
216597012978	ABC transporter signature motif; other site
216597012979	Walker B; other site
216597012980	D-loop; other site
216597012981	H-loop/switch region; other site
216597012982	TOBE domain; Region: TOBE_2; pfam08402
216597012983	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
216597012984	trimer interface; other site
216597012985	sugar binding site [chemical binding]; other site
216597012986	maltose regulon periplasmic protein; Provisional; Region: PRK10564
216597012987	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
216597012988	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
216597012989	UbiA prenyltransferase family; Region: UbiA; pfam01040
216597012990	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
216597012991	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
216597012992	putative acyl-acceptor binding pocket; other site
216597012993	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
216597012994	LexA repressor; Validated; Region: PRK00215
216597012995	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
216597012996	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216597012997	Catalytic site [active]
216597012998	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
216597012999	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
216597013000	hypothetical protein; Provisional; Region: PRK10428
216597013001	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
216597013002	metal binding site 2 [ion binding]; metal-binding site
216597013003	putative DNA binding helix; other site
216597013004	metal binding site 1 [ion binding]; metal-binding site
216597013005	dimer interface [polypeptide binding]; other site
216597013006	structural Zn2+ binding site [ion binding]; other site
216597013007	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
216597013008	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
216597013009	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
216597013010	FMN binding site [chemical binding]; other site
216597013011	active site
216597013012	catalytic residues [active]
216597013013	substrate binding site [chemical binding]; other site
216597013014	phage shock protein G; Reviewed; Region: pspG; PRK09459
216597013015	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
216597013016	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
216597013017	NADP binding site [chemical binding]; other site
216597013018	dimer interface [polypeptide binding]; other site
216597013019	replicative DNA helicase; Provisional; Region: PRK08006
216597013020	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
216597013021	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
216597013022	Walker A motif; other site
216597013023	ATP binding site [chemical binding]; other site
216597013024	Walker B motif; other site
216597013025	DNA binding loops [nucleotide binding]
216597013026	alanine racemase; Reviewed; Region: alr; PRK00053
216597013027	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
216597013028	active site
216597013029	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216597013030	substrate binding site [chemical binding]; other site
216597013031	catalytic residues [active]
216597013032	dimer interface [polypeptide binding]; other site
216597013033	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
216597013034	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216597013035	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597013036	homodimer interface [polypeptide binding]; other site
216597013037	catalytic residue [active]
216597013038	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
216597013039	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597013040	active site
216597013041	motif I; other site
216597013042	motif II; other site
216597013043	Uncharacterized conserved protein [Function unknown]; Region: COG0432
216597013044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
216597013045	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
216597013046	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
216597013047	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
216597013048	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
216597013049	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
216597013050	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
216597013051	dimer interface [polypeptide binding]; other site
216597013052	ssDNA binding site [nucleotide binding]; other site
216597013053	tetramer (dimer of dimers) interface [polypeptide binding]; other site
216597013054	hypothetical protein; Validated; Region: PRK09039
216597013055	Zinc finger-containing protein; Region: zf-C4H2; pfam10146
216597013056	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
216597013057	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
216597013058	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216597013059	HlyD family secretion protein; Region: HlyD_3; pfam13437
216597013060	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
216597013061	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013062	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013063	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013064	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013065	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013066	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
216597013067	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
216597013068	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013069	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
216597013070	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
216597013071	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013072	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
216597013073	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013074	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
216597013075	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
216597013076	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013077	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
216597013078	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013079	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
216597013080	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
216597013081	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013082	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
216597013083	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
216597013084	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013085	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
216597013086	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013087	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013088	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
216597013089	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013090	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013091	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013092	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013093	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013094	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
216597013095	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013096	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
216597013097	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013098	Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245
216597013099	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013100	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
216597013101	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
216597013102	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597013103	Walker A/P-loop; other site
216597013104	ATP binding site [chemical binding]; other site
216597013105	Q-loop/lid; other site
216597013106	ABC transporter signature motif; other site
216597013107	Walker B; other site
216597013108	D-loop; other site
216597013109	H-loop/switch region; other site
216597013110	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
216597013111	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
216597013112	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597013113	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
216597013114	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597013115	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
216597013116	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
216597013117	DNA binding residues [nucleotide binding]
216597013118	dimer interface [polypeptide binding]; other site
216597013119	[2Fe-2S] cluster binding site [ion binding]; other site
216597013120	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216597013121	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
216597013122	putative C-terminal domain interface [polypeptide binding]; other site
216597013123	putative GSH binding site (G-site) [chemical binding]; other site
216597013124	putative dimer interface [polypeptide binding]; other site
216597013125	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
216597013126	putative N-terminal domain interface [polypeptide binding]; other site
216597013127	putative dimer interface [polypeptide binding]; other site
216597013128	putative substrate binding pocket (H-site) [chemical binding]; other site
216597013129	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
216597013130	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
216597013131	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
216597013132	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216597013133	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597013134	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
216597013135	putative dimerization interface [polypeptide binding]; other site
216597013136	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
216597013137	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
216597013138	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
216597013139	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
216597013140	Na binding site [ion binding]; other site
216597013141	Predicted membrane protein [Function unknown]; Region: COG3162
216597013142	acetyl-CoA synthetase; Provisional; Region: PRK00174
216597013143	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
216597013144	active site
216597013145	CoA binding site [chemical binding]; other site
216597013146	acyl-activating enzyme (AAE) consensus motif; other site
216597013147	AMP binding site [chemical binding]; other site
216597013148	acetate binding site [chemical binding]; other site
216597013149	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
216597013150	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
216597013151	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
216597013152	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
216597013153	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
216597013154	heme lyase subunit NrfE; Provisional; Region: PRK10369
216597013155	formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144
216597013156	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
216597013157	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
216597013158	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216597013159	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
216597013160	Sel1-like repeats; Region: SEL1; smart00671
216597013161	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
216597013162	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
216597013163	[4Fe-4S] binding site [ion binding]; other site
216597013164	molybdopterin cofactor binding site; other site
216597013165	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
216597013166	molybdopterin cofactor binding site; other site
216597013167	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
216597013168	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597013169	Coenzyme A binding pocket [chemical binding]; other site
216597013170	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
216597013171	dimer interface [polypeptide binding]; other site
216597013172	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216597013173	hypothetical protein; Provisional; Region: PRK10220
216597013174	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
216597013175	PhnA protein; Region: PhnA; pfam03831
216597013176	proline/glycine betaine transporter; Provisional; Region: PRK10642
216597013177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597013178	putative substrate translocation pore; other site
216597013179	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
216597013180	sensor protein BasS/PmrB; Provisional; Region: PRK10755
216597013181	HAMP domain; Region: HAMP; pfam00672
216597013182	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597013183	dimer interface [polypeptide binding]; other site
216597013184	phosphorylation site [posttranslational modification]
216597013185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597013186	ATP binding site [chemical binding]; other site
216597013187	Mg2+ binding site [ion binding]; other site
216597013188	G-X-G motif; other site
216597013189	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
216597013190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597013191	active site
216597013192	phosphorylation site [posttranslational modification]
216597013193	intermolecular recognition site; other site
216597013194	dimerization interface [polypeptide binding]; other site
216597013195	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597013196	DNA binding site [nucleotide binding]
216597013197	putative metal dependent hydrolase; Provisional; Region: PRK11598
216597013198	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
216597013199	Sulfatase; Region: Sulfatase; pfam00884
216597013200	arginine:agmatin antiporter; Provisional; Region: PRK10644
216597013201	DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978
216597013202	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597013203	arginine decarboxylase; Provisional; Region: PRK15029
216597013204	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
216597013205	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
216597013206	homodimer interface [polypeptide binding]; other site
216597013207	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216597013208	catalytic residue [active]
216597013209	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
216597013210	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
216597013211	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597013212	alpha-galactosidase; Provisional; Region: PRK15076
216597013213	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
216597013214	NAD binding site [chemical binding]; other site
216597013215	sugar binding site [chemical binding]; other site
216597013216	divalent metal binding site [ion binding]; other site
216597013217	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
216597013218	dimer interface [polypeptide binding]; other site
216597013219	melibiose:sodium symporter; Provisional; Region: PRK10429
216597013220	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
216597013221	fumarate hydratase; Provisional; Region: PRK15389
216597013222	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
216597013223	Fumarase C-terminus; Region: Fumerase_C; pfam05683
216597013224	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
216597013225	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
216597013226	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
216597013227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597013228	active site
216597013229	phosphorylation site [posttranslational modification]
216597013230	intermolecular recognition site; other site
216597013231	dimerization interface [polypeptide binding]; other site
216597013232	sensory histidine kinase DcuS; Provisional; Region: PRK11086
216597013233	PAS domain; Region: PAS; smart00091
216597013234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597013235	ATP binding site [chemical binding]; other site
216597013236	Mg2+ binding site [ion binding]; other site
216597013237	G-X-G motif; other site
216597013238	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
216597013239	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
216597013240	putative [Fe4-S4] binding site [ion binding]; other site
216597013241	putative molybdopterin cofactor binding site [chemical binding]; other site
216597013242	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
216597013243	putative molybdopterin cofactor binding site; other site
216597013244	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
216597013245	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
216597013246	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
216597013247	Domain of unknown function (DUF1996); Region: DUF1996; pfam09362
216597013248	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
216597013249	SdiA-regulated; Region: SdiA-regulated; cd09971
216597013250	putative active site [active]
216597013251	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216597013252	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597013253	DNA binding residues [nucleotide binding]
216597013254	dimerization interface [polypeptide binding]; other site
216597013255	AraC family transcriptional regulator; Provisional; Region: PRK15186
216597013256	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597013257	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
216597013258	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597013259	Coenzyme A binding pocket [chemical binding]; other site
216597013260	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
216597013261	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
216597013262	active site
216597013263	EthD domain; Region: EthD; pfam07110
216597013264	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
216597013265	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
216597013266	DNA binding residues [nucleotide binding]
216597013267	putative dimer interface [polypeptide binding]; other site
216597013268	putative transcriptional regulator; Provisional; Region: PRK11640
216597013269	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216597013270	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
216597013271	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
216597013272	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
216597013273	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
216597013274	DsbD alpha interface [polypeptide binding]; other site
216597013275	catalytic residues [active]
216597013276	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
216597013277	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
216597013278	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
216597013279	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
216597013280	Aspartase; Region: Aspartase; cd01357
216597013281	active sites [active]
216597013282	tetramer interface [polypeptide binding]; other site
216597013283	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
216597013284	putative transporter; Provisional; Region: PRK11021
216597013285	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
216597013286	oligomerisation interface [polypeptide binding]; other site
216597013287	mobile loop; other site
216597013288	roof hairpin; other site
216597013289	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
216597013290	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
216597013291	ring oligomerisation interface [polypeptide binding]; other site
216597013292	ATP/Mg binding site [chemical binding]; other site
216597013293	stacking interactions; other site
216597013294	hinge regions; other site
216597013295	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
216597013296	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
216597013297	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597013298	FeS/SAM binding site; other site
216597013299	elongation factor P; Validated; Region: PRK00529
216597013300	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
216597013301	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
216597013302	RNA binding site [nucleotide binding]; other site
216597013303	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
216597013304	RNA binding site [nucleotide binding]; other site
216597013305	Predicted small secreted protein [Function unknown]; Region: COG5510
216597013306	entericidin B membrane lipoprotein; Provisional; Region: PRK10081
216597013307	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216597013308	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597013309	DNA binding residues [nucleotide binding]
216597013310	dimerization interface [polypeptide binding]; other site
216597013311	multidrug efflux system protein; Provisional; Region: PRK11431
216597013312	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
216597013313	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
216597013314	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
216597013315	Iron-sulfur protein interface; other site
216597013316	proximal quinone binding site [chemical binding]; other site
216597013317	C-subunit interface; other site
216597013318	distal quinone binding site; other site
216597013319	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
216597013320	D-subunit interface [polypeptide binding]; other site
216597013321	Iron-sulfur protein interface; other site
216597013322	proximal quinone binding site [chemical binding]; other site
216597013323	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
216597013324	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
216597013325	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
216597013326	L-aspartate oxidase; Provisional; Region: PRK06175
216597013327	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
216597013328	poxB regulator PoxA; Provisional; Region: PRK09350
216597013329	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
216597013330	motif 1; other site
216597013331	dimer interface [polypeptide binding]; other site
216597013332	active site
216597013333	motif 2; other site
216597013334	motif 3; other site
216597013335	inner membrane transporter YjeM; Provisional; Region: PRK15238
216597013336	Protein of unknown function (DUF2645); Region: DUF2645; pfam10840
216597013337	putative mechanosensitive channel protein; Provisional; Region: PRK10929
216597013338	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
216597013339	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216597013340	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
216597013341	GTPase RsgA; Reviewed; Region: PRK12288
216597013342	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
216597013343	RNA binding site [nucleotide binding]; other site
216597013344	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
216597013345	GTPase/Zn-binding domain interface [polypeptide binding]; other site
216597013346	GTP/Mg2+ binding site [chemical binding]; other site
216597013347	G4 box; other site
216597013348	G5 box; other site
216597013349	G1 box; other site
216597013350	Switch I region; other site
216597013351	G2 box; other site
216597013352	G3 box; other site
216597013353	Switch II region; other site
216597013354	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
216597013355	catalytic site [active]
216597013356	putative active site [active]
216597013357	putative substrate binding site [chemical binding]; other site
216597013358	dimer interface [polypeptide binding]; other site
216597013359	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
216597013360	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216597013361	substrate binding pocket [chemical binding]; other site
216597013362	membrane-bound complex binding site; other site
216597013363	hinge residues; other site
216597013364	epoxyqueuosine reductase; Region: TIGR00276
216597013365	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
216597013366	putative carbohydrate kinase; Provisional; Region: PRK10565
216597013367	Uncharacterized conserved protein [Function unknown]; Region: COG0062
216597013368	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
216597013369	putative substrate binding site [chemical binding]; other site
216597013370	putative ATP binding site [chemical binding]; other site
216597013371	ADP-binding protein; Provisional; Region: PRK10646
216597013372	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
216597013373	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
216597013374	active site
216597013375	metal binding site [ion binding]; metal-binding site
216597013376	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
216597013377	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597013378	ATP binding site [chemical binding]; other site
216597013379	Mg2+ binding site [ion binding]; other site
216597013380	G-X-G motif; other site
216597013381	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
216597013382	ATP binding site [chemical binding]; other site
216597013383	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
216597013384	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
216597013385	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
216597013386	bacterial Hfq-like; Region: Hfq; cd01716
216597013387	hexamer interface [polypeptide binding]; other site
216597013388	Sm1 motif; other site
216597013389	RNA binding site [nucleotide binding]; other site
216597013390	Sm2 motif; other site
216597013391	GTPase HflX; Provisional; Region: PRK11058
216597013392	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
216597013393	HflX GTPase family; Region: HflX; cd01878
216597013394	G1 box; other site
216597013395	GTP/Mg2+ binding site [chemical binding]; other site
216597013396	Switch I region; other site
216597013397	G2 box; other site
216597013398	G3 box; other site
216597013399	Switch II region; other site
216597013400	G4 box; other site
216597013401	G5 box; other site
216597013402	FtsH protease regulator HflK; Provisional; Region: PRK10930
216597013403	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
216597013404	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
216597013405	FtsH protease regulator HflC; Provisional; Region: PRK11029
216597013406	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
216597013407	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
216597013408	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
216597013409	GDP-binding site [chemical binding]; other site
216597013410	ACT binding site; other site
216597013411	IMP binding site; other site
216597013412	Predicted transcriptional regulator [Transcription]; Region: COG1959
216597013413	transcriptional repressor NsrR; Provisional; Region: PRK11014
216597013414	exoribonuclease R; Provisional; Region: PRK11642
216597013415	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
216597013416	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
216597013417	RNB domain; Region: RNB; pfam00773
216597013418	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
216597013419	RNA binding site [nucleotide binding]; other site
216597013420	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
216597013421	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
216597013422	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
216597013423	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789
216597013425	Ion channel; Region: Ion_trans_2; pfam07885
216597013426	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
216597013427	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
216597013428	Predicted membrane protein [Function unknown]; Region: COG3766
216597013429	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
216597013430	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
216597013431	Predicted integral membrane protein [Function unknown]; Region: COG5463
216597013432	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
216597013433	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
216597013434	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
216597013435	FAD binding site [chemical binding]; other site
216597013436	substrate binding site [chemical binding]; other site
216597013437	catalytic residues [active]
216597013438	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
216597013439	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
216597013440	esterase; Provisional; Region: PRK10566
216597013441	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216597013442	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216597013443	transcriptional repressor UlaR; Provisional; Region: PRK13509
216597013444	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
216597013445	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216597013446	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
216597013447	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
216597013448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
216597013449	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
216597013450	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
216597013451	active site
216597013452	P-loop; other site
216597013453	phosphorylation site [posttranslational modification]
216597013454	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216597013455	active site
216597013456	phosphorylation site [posttranslational modification]
216597013457	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
216597013458	active site
216597013459	dimer interface [polypeptide binding]; other site
216597013460	magnesium binding site [ion binding]; other site
216597013461	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
216597013462	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
216597013463	AP (apurinic/apyrimidinic) site pocket; other site
216597013464	DNA interaction; other site
216597013465	Metal-binding active site; metal-binding site
216597013466	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
216597013467	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
216597013468	intersubunit interface [polypeptide binding]; other site
216597013469	active site
216597013470	Zn2+ binding site [ion binding]; other site
216597013471	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
216597013472	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
216597013473	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
216597013474	dimer interface [polypeptide binding]; other site
216597013475	ssDNA binding site [nucleotide binding]; other site
216597013476	tetramer (dimer of dimers) interface [polypeptide binding]; other site
216597013477	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
216597013478	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
216597013479	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
216597013480	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
216597013481	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216597013482	EamA-like transporter family; Region: EamA; pfam00892
216597013483	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
216597013484	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
216597013485	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
216597013486	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
216597013487	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
216597013488	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
216597013489	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
216597013490	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
216597013491	Hemerythrin-like domain; Region: Hr-like; cd12108
216597013492	Fe binding site [ion binding]; other site
216597013493	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216597013494	EamA-like transporter family; Region: EamA; pfam00892
216597013495	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
216597013496	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
216597013497	NADP binding site [chemical binding]; other site
216597013498	Predicted transcriptional regulators [Transcription]; Region: COG1733
216597013499	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
216597013500	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
216597013501	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
216597013502	active site
216597013503	metal binding site [ion binding]; metal-binding site
216597013504	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
216597013505	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
216597013506	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
216597013507	active site
216597013508	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
216597013509	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
216597013510	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
216597013511	Domain of unknown function DUF21; Region: DUF21; pfam01595
216597013512	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
216597013513	Transporter associated domain; Region: CorC_HlyC; smart01091
216597013514	methionine sulfoxide reductase A; Provisional; Region: PRK00058
216597013515	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
216597013516	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216597013517	Surface antigen; Region: Bac_surface_Ag; pfam01103
216597013518	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
216597013519	Family of unknown function (DUF490); Region: DUF490; pfam04357
216597013520	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
216597013521	putative active site pocket [active]
216597013522	dimerization interface [polypeptide binding]; other site
216597013523	putative catalytic residue [active]
216597013524	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597013525	D-galactonate transporter; Region: 2A0114; TIGR00893
216597013526	putative substrate translocation pore; other site
216597013527	putative metallo-dependent hydrolase; Provisional; Region: PRK12394
216597013528	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
216597013529	active site
216597013530	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
216597013531	dimer interface [polypeptide binding]; other site
216597013532	substrate binding site [chemical binding]; other site
216597013533	metal binding sites [ion binding]; metal-binding site
216597013534	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
216597013535	AMP binding site [chemical binding]; other site
216597013536	metal binding site [ion binding]; metal-binding site
216597013537	active site
216597013538	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
216597013539	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
216597013540	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216597013541	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
216597013542	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
216597013543	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
216597013544	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
216597013545	putative active site [active]
216597013546	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
216597013547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597013548	putative substrate translocation pore; other site
216597013549	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597013550	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
216597013551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597013552	putative substrate translocation pore; other site
216597013553	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597013554	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
216597013555	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
216597013556	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
216597013557	tetrameric interface [polypeptide binding]; other site
216597013558	NAD binding site [chemical binding]; other site
216597013559	catalytic residues [active]
216597013560	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216597013561	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216597013562	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597013563	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
216597013564	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
216597013565	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216597013566	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
216597013567	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
216597013568	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
216597013569	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
216597013570	major facilitator superfamily transporter; Provisional; Region: PRK05122
216597013571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597013572	putative substrate translocation pore; other site
216597013573	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216597013574	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
216597013575	substrate binding site [chemical binding]; other site
216597013576	ATP binding site [chemical binding]; other site
216597013577	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
216597013578	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
216597013579	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
216597013580	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
216597013581	PYR/PP interface [polypeptide binding]; other site
216597013582	dimer interface [polypeptide binding]; other site
216597013583	TPP binding site [chemical binding]; other site
216597013584	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216597013585	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
216597013586	TPP-binding site; other site
216597013587	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
216597013588	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216597013589	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
216597013590	polyol permease family; Region: 2A0118; TIGR00897
216597013591	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597013592	putative substrate translocation pore; other site
216597013593	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
216597013594	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
216597013595	DNA interaction; other site
216597013596	Metal-binding active site; metal-binding site
216597013597	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
216597013598	hypothetical protein; Provisional; Region: PRK05255
216597013599	peptidase PmbA; Provisional; Region: PRK11040
216597013600	cytochrome b562; Provisional; Region: PRK15058
216597013601	match to SC4294 38..51 blast score 31.2 percent identity 100 SC4294 hypothetical protein 4598157:4598312 forward MW:5627
216597013602	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
216597013603	conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577
216597013604	conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578
216597013605	conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580
216597013606	conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579
216597013607	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
216597013608	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
216597013609	active site
216597013610	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
216597013611	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
216597013612	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
216597013613	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
216597013614	HTH domain; Region: HTH_11; pfam08279
216597013615	Mga helix-turn-helix domain; Region: Mga; pfam05043
216597013616	PRD domain; Region: PRD; pfam00874
216597013617	PRD domain; Region: PRD; pfam00874
216597013618	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
216597013619	active site
216597013620	P-loop; other site
216597013621	phosphorylation site [posttranslational modification]
216597013622	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216597013623	active site
216597013624	phosphorylation site [posttranslational modification]
216597013625	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
216597013626	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
216597013627	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
216597013628	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597013629	FeS/SAM binding site; other site
216597013630	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
216597013631	ATP cone domain; Region: ATP-cone; pfam03477
216597013632	Class III ribonucleotide reductase; Region: RNR_III; cd01675
216597013633	effector binding site; other site
216597013634	active site
216597013635	Zn binding site [ion binding]; other site
216597013636	glycine loop; other site
216597013637	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
216597013638	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
216597013639	Ca binding site [ion binding]; other site
216597013640	active site
216597013641	catalytic site [active]
216597013642	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
216597013644	trehalose repressor; Provisional; Region: treR; PRK09492
216597013645	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597013646	DNA binding site [nucleotide binding]
216597013647	domain linker motif; other site
216597013648	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
216597013649	dimerization interface [polypeptide binding]; other site
216597013650	ligand binding site [chemical binding]; other site
216597013651	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
216597013652	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
216597013653	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216597013654	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
216597013655	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
216597013656	Soluble P-type ATPase [General function prediction only]; Region: COG4087
216597013657	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
216597013658	Transposase; Region: HTH_Tnp_1; cl17663
216597013659	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
216597013660	homotrimer interaction site [polypeptide binding]; other site
216597013661	putative active site [active]
216597013662	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
216597013663	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
216597013664	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
216597013665	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
216597013666	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
216597013667	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
216597013668	pyrBI operon leader peptide; Provisional; Region: PRK10224
216597013669	Arginine repressor [Transcription]; Region: ArgR; COG1438
216597013670	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
216597013671	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
216597013672	Predicted membrane protein [Function unknown]; Region: COG1288
216597013673	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
216597013674	ornithine carbamoyltransferase; Validated; Region: PRK02102
216597013675	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
216597013676	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
216597013677	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
216597013678	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
216597013679	putative substrate binding site [chemical binding]; other site
216597013680	nucleotide binding site [chemical binding]; other site
216597013681	nucleotide binding site [chemical binding]; other site
216597013682	homodimer interface [polypeptide binding]; other site
216597013683	arginine deiminase; Provisional; Region: PRK01388
216597013684	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
216597013685	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
216597013686	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
216597013687	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
216597013688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
216597013689	RNase E inhibitor protein; Provisional; Region: PRK11191
216597013690	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
216597013691	active site
216597013692	dinuclear metal binding site [ion binding]; other site
216597013693	dimerization interface [polypeptide binding]; other site
216597013694	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
216597013695	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
216597013696	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597013697	Coenzyme A binding pocket [chemical binding]; other site
216597013698	Predicted membrane protein [Function unknown]; Region: COG4269
216597013699	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
216597013700	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
216597013701	HIGH motif; other site
216597013702	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
216597013703	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
216597013704	active site
216597013705	KMSKS motif; other site
216597013706	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
216597013707	tRNA binding surface [nucleotide binding]; other site
216597013708	anticodon binding site; other site
216597013709	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
216597013710	DNA polymerase III subunit chi; Validated; Region: PRK05728
216597013711	multifunctional aminopeptidase A; Provisional; Region: PRK00913
216597013712	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
216597013713	interface (dimer of trimers) [polypeptide binding]; other site
216597013714	Substrate-binding/catalytic site; other site
216597013715	Zn-binding sites [ion binding]; other site
216597013716	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
216597013717	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
216597013718	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
216597013719	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
216597013720	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
216597013721	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216597013722	DNA binding site [nucleotide binding]
216597013723	domain linker motif; other site
216597013724	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
216597013725	putative dimerization interface [polypeptide binding]; other site
216597013726	putative ligand binding site [chemical binding]; other site
216597013727	gluconate transporter; Region: gntP; TIGR00791
216597013728	fructuronate transporter; Provisional; Region: PRK10034; cl15264
216597013729	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
216597013730	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
216597013731	NADP binding site [chemical binding]; other site
216597013732	homodimer interface [polypeptide binding]; other site
216597013733	active site
216597013734	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
216597013735	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
216597013736	putative NAD(P) binding site [chemical binding]; other site
216597013737	catalytic Zn binding site [ion binding]; other site
216597013738	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
216597013739	ATP-binding site [chemical binding]; other site
216597013740	Gluconate-6-phosphate binding site [chemical binding]; other site
216597013741	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
216597013742	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
216597013743	putative NAD(P) binding site [chemical binding]; other site
216597013744	putative substrate binding site [chemical binding]; other site
216597013745	catalytic Zn binding site [ion binding]; other site
216597013746	structural Zn binding site [ion binding]; other site
216597013747	dimer interface [polypeptide binding]; other site
216597013749	Part of AAA domain; Region: AAA_19; pfam13245
216597013750	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
216597013751	AAA domain; Region: AAA_12; pfam13087
216597013752	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
216597013753	putative active site [active]
216597013754	catalytic site [active]
216597013755	Uncharacterized conserved protein [Function unknown]; Region: COG4127
216597013756	Restriction endonuclease; Region: Mrr_cat; pfam04471
216597013757	conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653
216597013758	Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337
216597013759	TIGR02687 family protein; Region: TIGR02687
216597013760	PglZ domain; Region: PglZ; pfam08665
216597013761	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597013762	AAA domain; Region: AAA_21; pfam13304
216597013763	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597013764	Walker A/P-loop; other site
216597013765	Walker A/P-loop; other site
216597013766	ATP binding site [chemical binding]; other site
216597013767	ATP binding site [chemical binding]; other site
216597013768	Q-loop/lid; other site
216597013769	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
216597013770	Methyltransferase domain; Region: Methyltransf_26; pfam13659
216597013771	TIGR02680 family protein; Region: TIGR02680
216597013772	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
216597013773	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
216597013775	hypothetical protein; Provisional; Region: PRK12378
216597013776	Methyltransferase domain; Region: Methyltransf_23; pfam13489
216597013777	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597013778	S-adenosylmethionine binding site [chemical binding]; other site
216597013779	Methyltransferase domain; Region: Methyltransf_31; pfam13847
216597013780	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597013781	S-adenosylmethionine binding site [chemical binding]; other site
216597013782	hypothetical protein; Provisional; Region: PRK13687
216597013783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332
216597013784	Uncharacterized conserved protein [Function unknown]; Region: COG3439
216597013785	Dienelactone hydrolase family; Region: DLH; pfam01738
216597013786	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
216597013787	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216597013788	DNA-binding site [nucleotide binding]; DNA binding site
216597013789	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216597013790	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
216597013791	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
216597013792	active site
216597013793	HIGH motif; other site
216597013794	dimer interface [polypeptide binding]; other site
216597013795	KMSKS motif; other site
216597013796	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
216597013797	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
216597013798	aspartate racemase; Region: asp_race; TIGR00035
216597013799	cell density-dependent motility repressor; Provisional; Region: PRK10082
216597013800	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597013801	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216597013802	dimerization interface [polypeptide binding]; other site
216597013803	isoaspartyl dipeptidase; Provisional; Region: PRK10657
216597013804	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
216597013805	active site
216597013806	hypothetical protein; Provisional; Region: PRK10519
216597013807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
216597013808	Nucleoside recognition; Region: Gate; pfam07670
216597013810	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
216597013811	Predicted membrane protein [Function unknown]; Region: COG2733
216597013812	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
216597013813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216597013814	putative substrate translocation pore; other site
216597013815	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
216597013816	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
216597013817	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
216597013818	NAD(P) binding site [chemical binding]; other site
216597013819	catalytic residues [active]
216597013820	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
216597013821	endoribonuclease SymE; Provisional; Region: PRK13605
216597013822	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
216597013823	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
216597013824	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
216597013825	HsdM N-terminal domain; Region: HsdM_N; pfam12161
216597013826	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
216597013827	Methyltransferase domain; Region: Methyltransf_26; pfam13659
216597013828	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
216597013829	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
216597013830	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
216597013831	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216597013832	ATP binding site [chemical binding]; other site
216597013833	putative Mg++ binding site [ion binding]; other site
216597013834	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
216597013835	Mrr N-terminal domain; Region: Mrr_N; pfam14338
216597013836	Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030
216597013837	Restriction endonuclease; Region: Mrr_cat; pfam04471
216597013838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
216597013839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
216597013840	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
216597013841	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
216597013842	P-loop, Walker A motif; other site
216597013843	Base recognition motif; other site
216597013844	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
216597013845	Uncharacterized small protein [Function unknown]; Region: COG2879
216597013846	carbon starvation protein A; Provisional; Region: PRK15015
216597013847	Carbon starvation protein CstA; Region: CstA; pfam02554
216597013848	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
216597013849	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
216597013850	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
216597013851	dimer interface [polypeptide binding]; other site
216597013852	ligand binding site [chemical binding]; other site
216597013853	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216597013854	dimerization interface [polypeptide binding]; other site
216597013855	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216597013856	dimer interface [polypeptide binding]; other site
216597013857	putative CheW interface [polypeptide binding]; other site
216597013858	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
216597013859	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597013860	Walker A motif; other site
216597013861	ATP binding site [chemical binding]; other site
216597013862	Walker B motif; other site
216597013863	arginine finger; other site
216597013864	Transcriptional antiterminator [Transcription]; Region: COG3933
216597013865	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
216597013866	active pocket/dimerization site; other site
216597013867	active site
216597013868	phosphorylation site [posttranslational modification]
216597013869	PRD domain; Region: PRD; pfam00874
216597013870	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
216597013871	active pocket/dimerization site; other site
216597013872	active site
216597013873	phosphorylation site [posttranslational modification]
216597013874	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
216597013875	active site
216597013876	phosphorylation site [posttranslational modification]
216597013877	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
216597013878	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
216597013879	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
216597013880	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
216597013881	dimer interface [polypeptide binding]; other site
216597013882	active site
216597013883	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
216597013884	dimer interface [polypeptide binding]; other site
216597013885	active site
216597013886	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
216597013887	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
216597013888	putative active site [active]
216597013889	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
216597013890	phosphoglycerol transferase I; Provisional; Region: PRK03776
216597013891	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
216597013892	hypothetical protein; Provisional; Region: PRK11667
216597013893	DNA replication protein DnaC; Validated; Region: PRK07952
216597013894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216597013895	Walker A motif; other site
216597013896	ATP binding site [chemical binding]; other site
216597013897	Walker B motif; other site
216597013898	primosomal protein DnaI; Provisional; Region: PRK02854
216597013899	hypothetical protein; Provisional; Region: PRK09917
216597013900	Uncharacterized conserved protein [Function unknown]; Region: COG2966
216597013901	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
216597013902	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216597013903	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597013904	DNA binding residues [nucleotide binding]
216597013905	dimerization interface [polypeptide binding]; other site
216597013906	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
216597013907	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597013908	DNA binding residues [nucleotide binding]
216597013909	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
216597013910	putative deacylase active site [active]
216597013911	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
216597013912	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
216597013913	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
216597013914	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216597013915	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216597013916	metal binding site [ion binding]; metal-binding site
216597013917	active site
216597013918	I-site; other site
216597013919	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
216597013920	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
216597013921	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
216597013922	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216597013923	S-adenosylmethionine binding site [chemical binding]; other site
216597013924	DNA polymerase III subunit psi; Validated; Region: PRK06856
216597013925	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
216597013926	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216597013927	Coenzyme A binding pocket [chemical binding]; other site
216597013928	dUMP phosphatase; Provisional; Region: PRK09449
216597013929	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597013930	motif II; other site
216597013931	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
216597013932	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
216597013933	G1 box; other site
216597013934	putative GEF interaction site [polypeptide binding]; other site
216597013935	GTP/Mg2+ binding site [chemical binding]; other site
216597013936	Switch I region; other site
216597013937	G2 box; other site
216597013938	G3 box; other site
216597013939	Switch II region; other site
216597013940	G4 box; other site
216597013941	G5 box; other site
216597013942	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
216597013943	periplasmic protein; Provisional; Region: PRK10568
216597013944	BON domain; Region: BON; pfam04972
216597013945	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
216597013946	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
216597013947	active site
216597013948	nucleophile elbow; other site
216597013949	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
216597013950	active site
216597013951	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
216597013952	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216597013953	FeS/SAM binding site; other site
216597013954	hypothetical protein; Provisional; Region: PRK10977
216597013955	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
216597013956	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
216597013957	intersubunit interface [polypeptide binding]; other site
216597013958	active site
216597013959	catalytic residue [active]
216597013960	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
216597013961	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
216597013962	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
216597013963	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
216597013964	phosphopentomutase; Provisional; Region: PRK05362
216597013965	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
216597013966	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
216597013967	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
216597013968	hypothetical protein; Provisional; Region: PRK15301
216597013969	putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304
216597013970	PapC N-terminal domain; Region: PapC_N; pfam13954
216597013971	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216597013972	PapC C-terminal domain; Region: PapC_C; pfam13953
216597013973	putative fimbrial chaperone protein; Provisional; Region: PRK09918
216597013974	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597013975	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597013976	hypothetical protein; Provisional; Region: PRK15302
216597013977	hypothetical protein; Provisional; Region: PRK15303
216597013978	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
216597013979	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
216597013980	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
216597013981	hypothetical protein; Provisional; Region: PRK11246
216597013982	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
216597013983	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216597013984	motif II; other site
216597013985	DNA repair protein RadA; Region: sms; TIGR00416
216597013986	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
216597013987	Walker A motif/ATP binding site; other site
216597013988	ATP binding site [chemical binding]; other site
216597013989	Walker B motif; other site
216597013990	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
216597013991	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216597013992	non-specific DNA binding site [nucleotide binding]; other site
216597013993	salt bridge; other site
216597013994	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
216597013995	sequence-specific DNA binding site [nucleotide binding]; other site
216597013996	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
216597013997	active site
216597013998	(T/H)XGH motif; other site
216597013999	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
216597014000	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
216597014001	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216597014002	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216597014003	ABC transporter; Region: ABC_tran_2; pfam12848
216597014004	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216597014005	lytic murein transglycosylase; Provisional; Region: PRK11619
216597014006	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216597014007	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216597014008	catalytic residue [active]
216597014009	Trp operon repressor; Provisional; Region: PRK01381
216597014010	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
216597014011	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
216597014012	catalytic core [active]
216597014013	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
216597014014	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597014015	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
216597014016	hypothetical protein; Provisional; Region: PRK10756
216597014017	CreA protein; Region: CreA; pfam05981
216597014018	DNA-binding response regulator CreB; Provisional; Region: PRK11083
216597014019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597014020	active site
216597014021	phosphorylation site [posttranslational modification]
216597014022	intermolecular recognition site; other site
216597014023	dimerization interface [polypeptide binding]; other site
216597014024	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597014025	DNA binding site [nucleotide binding]
216597014026	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
216597014027	dimerization interface [polypeptide binding]; other site
216597014028	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216597014029	dimer interface [polypeptide binding]; other site
216597014030	phosphorylation site [posttranslational modification]
216597014031	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
216597014032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216597014033	ATP binding site [chemical binding]; other site
216597014034	Mg2+ binding site [ion binding]; other site
216597014035	G-X-G motif; other site
216597014036	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
216597014037	putative major fimbrial protein SthE; Provisional; Region: PRK15292
216597014038	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
216597014039	putative fimbrial protein SthD; Provisional; Region: PRK15293
216597014040	putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294
216597014041	PapC N-terminal domain; Region: PapC_N; pfam13954
216597014042	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216597014043	PapC C-terminal domain; Region: PapC_C; pfam13953
216597014044	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
216597014045	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597014046	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597014047	putative fimbrial protein SthA; Provisional; Region: PRK15296
216597014048	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
216597014049	Helix-turn-helix domain; Region: HTH_36; pfam13730
216597014051	two-component response regulator; Provisional; Region: PRK11173
216597014052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216597014053	active site
216597014054	phosphorylation site [posttranslational modification]
216597014055	intermolecular recognition site; other site
216597014056	dimerization interface [polypeptide binding]; other site
216597014057	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216597014058	DNA binding site [nucleotide binding]
216597014059	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
216597014060	putative RNA methyltransferase; Provisional; Region: PRK10433
216597014061	IncFII RepA protein family; Region: IncFII_repA; cl11495
216597014062	RelB antitoxin; Region: RelB; cl01171
216597014063	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
216597014064	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
216597014065	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
216597014066	active site
216597014067	catalytic site [active]
216597014068	substrate binding site [chemical binding]; other site
216597014069	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236
216597014070	putative kissing complex interaction region; other site
216597014071	putative RNA binding sites [nucleotide binding]; other site
216597014072	Colicin Ia; Region: Colicin_Ia; pfam11504
216597014073	Colicin pore forming domain; Region: Colicin; pfam01024
216597014076	Phage integrase family; Region: Phage_integrase; pfam00589
216597014077	active site
216597014078	DNA binding site [nucleotide binding]
216597014079	Int/Topo IB signature motif; other site
216597014080	ParA-like protein; Provisional; Region: PHA02518
216597014081	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
216597014082	P-loop; other site
216597014083	Magnesium ion binding site [ion binding]; other site
216597014084	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
216597014085	Mg binding site [ion binding]; other site
216597014086	nucleotide binding site [chemical binding]; other site
216597014087	putative protofilament interface [polypeptide binding]; other site
216597014088	Plasmid stability protein; Region: Plasmid_stab_B; pfam10784
216597014089	part of the impCAB operon involved in uv protection. Function of impC is not essential
216597014090	Protein of unknown function (DUF1281); Region: DUF1281; pfam06924
216597014092	putative methylase; Provisional; Region: PRK13699
216597014093	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
216597014094	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
216597014095	Protein of unknown function (DUF1472); Region: DUF1472; pfam07339
216597014096	Antirestriction protein; Region: Antirestrict; pfam03230
216597014097	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
216597014099	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
216597014100	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
216597014101	dimer interface [polypeptide binding]; other site
216597014102	ssDNA binding site [nucleotide binding]; other site
216597014103	tetramer (dimer of dimers) interface [polypeptide binding]; other site
216597014104	ParB-like nuclease domain; Region: ParB; smart00470
216597014105	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
216597014106	KorB domain; Region: KorB; pfam08535
216597014107	plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701
216597014108	PsiA protein; Region: PsiA; pfam06952
216597014109	Protein of unknown function (DUF1472); Region: DUF1472; pfam07339
216597014110	Antirestriction protein (ArdA); Region: ArdA; pfam07275
216597014111	hypothetical protein; Provisional; Region: PRK09956
216597014112	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
216597014113	Methyltransferase domain; Region: Methyltransf_27; pfam13708
216597014114	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
216597014115	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
216597014116	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
216597014117	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
216597014118	dimerization domain [polypeptide binding]; other site
216597014119	dimer interface [polypeptide binding]; other site
216597014120	catalytic residues [active]
216597014121	Hok/gef family; Region: HOK_GEF; pfam01848
216597014122	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
216597014123	indole-3-acetamide amidohydrolase; Region: PLN02722
216597014124	AAA-like domain; Region: AAA_10; pfam12846
216597014125	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
216597014126	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
216597014127	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
216597014128	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
216597014129	active site
216597014130	metal binding site [ion binding]; metal-binding site
216597014131	interdomain interaction site; other site
216597014132	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
216597014133	PLD-like domain; Region: PLDc_2; pfam13091
216597014134	putative active site [active]
216597014135	catalytic site [active]
216597014136	plasmid transfer ATPase TraJ; Region: plasmid_TraJ; TIGR02525
216597014137	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216597014138	Walker A motif; other site
216597014139	ATP binding site [chemical binding]; other site
216597014140	Walker B motif; other site
216597014141	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
216597014142	catalytic core [active]
216597014143	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
216597014144	Rci recombinase, C-terminal catalytic domain.  Rci enzymes are found in IncI1 incompatibility group plasmids such as R64.  These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796
216597014145	catalytic residues [active]
216597014146	Int/Topo IB signature motif; other site
216597014147	Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917
216597014148	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
216597014149	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
216597014150	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216597014151	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216597014152	catalytic residue [active]
216597014153	PilS N terminal; Region: PilS; pfam08805
216597014154	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216597014155	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216597014156	Type II/IV secretion system protein; Region: T2SE; pfam00437
216597014157	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216597014158	Walker A motif; other site
216597014159	ATP binding site [chemical binding]; other site
216597014160	Walker B motif; other site
216597014161	type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021
216597014162	Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864
216597014163	type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520
216597014164	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
216597014165	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
216597014166	PilM; Region: PilM; pfam07419
216597014167	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
216597014168	Plasmid conjugative transfer protein PilI; Region: PilI; pfam10623
216597014169	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
216597014170	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
216597014171	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
216597014172	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
216597014173	dihydropteroate synthase; Region: DHPS; TIGR01496
216597014174	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
216597014175	substrate binding pocket [chemical binding]; other site
216597014176	dimer interface [polypeptide binding]; other site
216597014177	inhibitor binding site; inhibition site
216597014178	Replication protein C (RepC); Region: RepC; pfam06504
216597014179	AAA domain; Region: AAA_25; pfam13481
216597014180	Hexameric Replicative Helicase RepA.  RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125
216597014181	Walker A motif; other site
216597014182	NTP binding site [chemical binding]; other site
216597014183	hexamer interface [polypeptide binding]; other site
216597014184	Walker B motif; other site
216597014185	MobA/MobL family; Region: MobA_MobL; pfam03389
216597014186	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
216597014187	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655
216597014188	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
216597014189	Phosphotransferase enzyme family; Region: APH; pfam01636
216597014190	active site
216597014191	ATP binding site [chemical binding]; other site
216597014192	antibiotic binding site [chemical binding]; other site
216597014193	conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754
216597014194	Fertility inhibition protein N terminal; Region: FinO_N; pfam12602
216597014195	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236
216597014196	putative kissing complex interaction region; other site
216597014197	putative RNA binding sites [nucleotide binding]; other site
216597014198	TraX protein; Region: TraX; cl05434
216597014199	conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709
216597014200	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
216597014201	AAA domain; Region: AAA_30; pfam13604
216597014202	DNA helicase TraI; Region: TraI; pfam07057
216597014203	conjugal transfer protein TraD; Provisional; Region: PRK13700
216597014204	F sex factor protein N terminal; Region: TraD_N; pfam12615
216597014205	Bacterial conjugation protein TrwB,  ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127
216597014206	multimer interface [polypeptide binding]; other site
216597014207	Walker A motif; other site
216597014208	ATP binding site [chemical binding]; other site
216597014209	Walker B motif; other site
216597014210	conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731
216597014211	Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818
216597014212	Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624
216597014213	conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735
216597014214	conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723
216597014215	conjugal transfer protein TrbB; Provisional; Region: PRK13728
216597014216	conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727
216597014217	conjugal pilus assembly protein TraF; Provisional; Region: PRK13703
216597014218	F plasmid transfer operon protein; Region: TraF; pfam13728
216597014219	conjugal transfer protein TrbE; Provisional; Region: PRK13718
216597014220	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
216597014221	conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730
216597014222	conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737
216597014223	conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738
216597014224	conjugal transfer protein TrbI; Provisional; Region: PRK13717
216597014225	conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721
216597014226	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
216597014227	Domain of unknown function DUF87; Region: DUF87; pfam01935
216597014228	conjugal transfer protein TraR; Provisional; Region: PRK13715
216597014229	conjugal transfer protein TraV; Provisional; Region: PRK13733
216597014230	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
216597014231	conjugal transfer protein TrbD; Provisional; Region: PRK13724
216597014232	NTPase; Region: NTPase_1; cl17478
216597014233	TraP protein; Region: TraP; pfam07296
216597014234	conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729
216597014235	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
216597014236	conjugal transfer protein TraK; Provisional; Region: PRK13736
216597014237	TraK protein; Region: TraK; pfam06586
216597014238	conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726
216597014239	conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707
216597014240	conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734
216597014241	conjugal transfer protein TraY; Provisional; Region: PRK13740
216597014242	conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719
216597014243	conjugal transfer protein TraM; Provisional; Region: PRK13713
216597014244	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
216597014245	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216597014246	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216597014247	catalytic residue [active]
216597014248	PsiA protein; Region: PsiA; pfam06952
216597014249	Plasmid SOS inhibition protein (PsiB); Region: PsiB; pfam06290
216597014250	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
216597014251	ParB-like nuclease domain; Region: ParBc; pfam02195
216597014252	Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006
216597014253	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
216597014254	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
216597014255	dimer interface [polypeptide binding]; other site
216597014256	ssDNA binding site [nucleotide binding]; other site
216597014257	tetramer (dimer of dimers) interface [polypeptide binding]; other site
216597014258	DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440
216597014259	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
216597014260	Antirestriction protein; Region: Antirestrict; pfam03230
216597014261	Protein of unknown function (DUF1472); Region: DUF1472; pfam07339
216597014262	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
216597014263	putative methylase; Provisional; Region: PRK13699
216597014264	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
216597014265	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
216597014266	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216597014267	Catalytic site [active]
216597014268	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
216597014269	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
216597014270	active site
216597014271	DNA binding site [nucleotide binding]
216597014272	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
216597014273	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
216597014274	ParB-like nuclease domain; Region: ParBc; pfam02195
216597014275	ParB family; Region: ParB; pfam08775
216597014276	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
216597014277	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
216597014278	P-loop; other site
216597014279	Magnesium ion binding site [ion binding]; other site
216597014280	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
216597014281	Magnesium ion binding site [ion binding]; other site
216597014282	Uncharacterized conserved protein [Function unknown]; Region: COG5464
216597014283	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
216597014284	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
216597014285	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
216597014286	catalytic site [active]
216597014287	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
216597014288	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
216597014289	active site clefts [active]
216597014290	zinc binding site [ion binding]; other site
216597014291	dimer interface [polypeptide binding]; other site
216597014292	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
216597014293	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
216597014294	catalytic residues [active]
216597014295	catalytic nucleophile [active]
216597014296	Presynaptic Site I dimer interface [polypeptide binding]; other site
216597014297	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
216597014298	Synaptic Flat tetramer interface [polypeptide binding]; other site
216597014299	Synaptic Site I dimer interface [polypeptide binding]; other site
216597014300	DNA binding site [nucleotide binding]
216597014301	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
216597014302	DNA-binding interface [nucleotide binding]; DNA binding site
216597014303	Integrase core domain; Region: rve; pfam00665
216597014304	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
216597014305	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216597014306	Walker A/P-loop; other site
216597014307	Homeodomain-like domain; Region: HTH_23; pfam13384
216597014308	Winged helix-turn helix; Region: HTH_29; pfam13551
216597014309	Homeodomain-like domain; Region: HTH_32; pfam13565
216597014310	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
216597014311	DDE superfamily endonuclease; Region: DDE_3; pfam13358
216597014312	transcriptional regulator SpvR; Provisional; Region: PRK15243
216597014313	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216597014314	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216597014315	virulence protein SpvA; Provisional; Region: PRK15212
216597014316	virulence protein SpvB; Provisional; Region: PRK15244
216597014317	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
216597014318	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
216597014319	active site
216597014320	conformational flexibility of ligand binding pocket; other site
216597014321	ADP-ribosylating toxin turn-turn motif; other site
216597014322	Salmonella virulence-associated 28kDa protein; Region: VRP3; cl04142
216597014323	virulence protein SpvD; Provisional; Region: PRK15250
216597014324	Transposase IS200 like; Region: Y1_Tnp; pfam01797
216597014325	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
216597014326	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
216597014327	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
216597014328	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216597014329	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216597014330	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
216597014331	active site
216597014332	catalytic residues [active]
216597014333	DNA binding site [nucleotide binding]
216597014334	Int/Topo IB signature motif; other site
216597014335	plasmid maintenance protein CcdB; Provisional; Region: PRK13708
216597014336	plasmid maintenance protein CcdA; Provisional; Region: PRK13710
216597014337	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
216597014338	Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333
216597014339	fimbrial protein PefA; Provisional; Region: PRK15214
216597014340	PapC N-terminal domain; Region: PapC_N; pfam13954
216597014341	fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213
216597014342	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216597014343	fimbrial chaperone protein PefD; Provisional; Region: PRK15211
216597014344	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216597014345	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216597014346	FaeA-like protein; Region: FaeA; pfam04703
216597014347	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216597014348	DNA binding residues [nucleotide binding]
216597014349	dimerization interface [polypeptide binding]; other site
216597014350	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
216597014351	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
216597014352	catalytic residues [active]
216597014353	hinge region; other site
216597014354	alpha helical domain; other site
216597014355	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
216597014356	SdiA-regulated; Region: SdiA-regulated; cd09971
216597014357	putative active site [active]
216597014358	resistance to complement killing; Provisional; Region: PRK15240
216597014359	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216597014360	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216597014361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
216597014362	SdiA-regulated; Region: SdiA-regulated; cd09971
216597014363	replication protein; Provisional; Region: PRK13750
216597014364	RepA leader peptide Tap; Provisional; Region: PRK14745
216597014365	replication protein; Provisional; Region: PRK13702
216597014366	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
216597014367	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
216597014368	putative active site [active]
216597014369	catalytic site [active]
216597014370	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388