-- dump date 20140620_055427 -- class Genbank::misc_feature -- table misc_feature_note -- id note 909946000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 909946000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 909946000003 putative catalytic residues [active] 909946000004 putative nucleotide binding site [chemical binding]; other site 909946000005 putative aspartate binding site [chemical binding]; other site 909946000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 909946000007 dimer interface [polypeptide binding]; other site 909946000008 putative threonine allosteric regulatory site; other site 909946000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 909946000010 putative threonine allosteric regulatory site; other site 909946000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 909946000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 909946000013 homoserine kinase; Provisional; Region: PRK01212 909946000014 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 909946000015 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 909946000016 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 909946000017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946000018 catalytic residue [active] 909946000019 hypothetical protein; Validated; Region: PRK02101 909946000020 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 909946000021 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 909946000022 transaldolase-like protein; Provisional; Region: PTZ00411 909946000023 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 909946000024 active site 909946000025 dimer interface [polypeptide binding]; other site 909946000026 catalytic residue [active] 909946000027 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 909946000028 MPT binding site; other site 909946000029 trimer interface [polypeptide binding]; other site 909946000030 hypothetical protein; Provisional; Region: PRK10659 909946000031 hypothetical protein; Provisional; Region: PRK10236 909946000032 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 909946000033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 909946000034 Protein of unknown function (DUF2541); Region: DUF2541; pfam10807 909946000035 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 909946000036 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 909946000037 nucleotide binding site [chemical binding]; other site 909946000038 chaperone protein DnaJ; Provisional; Region: PRK10767 909946000039 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 909946000040 HSP70 interaction site [polypeptide binding]; other site 909946000041 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 909946000042 substrate binding site [polypeptide binding]; other site 909946000043 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 909946000044 Zn binding sites [ion binding]; other site 909946000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 909946000046 dimer interface [polypeptide binding]; other site 909946000047 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946000048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946000049 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 909946000050 substrate binding pocket [chemical binding]; other site 909946000051 dimerization interface [polypeptide binding]; other site 909946000052 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 909946000053 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 909946000054 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 909946000055 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 909946000056 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 909946000057 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 909946000058 active site 909946000059 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 909946000060 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 909946000061 aromatic chitin/cellulose binding site residues [chemical binding]; other site 909946000062 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 909946000063 Helix-turn-helix domain; Region: HTH_36; pfam13730 909946000064 fimbrial protein BcfA; Provisional; Region: PRK15187 909946000065 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 909946000066 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946000067 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946000068 outer membrane usher protein; Provisional; Region: PRK15193 909946000069 PapC N-terminal domain; Region: PapC_N; pfam13954 909946000070 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 909946000071 PapC C-terminal domain; Region: PapC_C; pfam13953 909946000072 fimbrial protein BcfD; Provisional; Region: PRK15189 909946000073 fimbrial protein BcfE; Provisional; Region: PRK15190 909946000074 fimbrial protein BcfF; Provisional; Region: PRK15191 909946000075 fimbrial chaperone BcfG; Provisional; Region: PRK15192 909946000076 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946000077 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946000078 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 909946000079 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 909946000080 catalytic residues [active] 909946000081 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 909946000082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946000083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946000084 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 909946000085 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 909946000086 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 909946000087 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 909946000088 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 909946000089 active site 909946000090 metal binding site [ion binding]; metal-binding site 909946000091 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 909946000092 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 909946000093 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 909946000094 Sulfatase; Region: Sulfatase; pfam00884 909946000095 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 909946000096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946000097 FeS/SAM binding site; other site 909946000098 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 909946000099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 909946000100 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 909946000101 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 909946000102 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 909946000103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946000104 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 909946000105 putative dimerization interface [polypeptide binding]; other site 909946000106 putative alpha-glucosidase; Provisional; Region: PRK10658 909946000107 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 909946000108 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 909946000109 putative active site [active] 909946000110 putative catalytic site [active] 909946000111 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 909946000112 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 909946000113 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 909946000114 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 909946000115 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 909946000116 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 909946000117 active site 909946000118 Riboflavin kinase; Region: Flavokinase; smart00904 909946000119 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 909946000120 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 909946000121 active site 909946000122 HIGH motif; other site 909946000123 nucleotide binding site [chemical binding]; other site 909946000124 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 909946000125 active site 909946000126 KMSKS motif; other site 909946000127 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 909946000128 tRNA binding surface [nucleotide binding]; other site 909946000129 anticodon binding site; other site 909946000130 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 909946000131 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 909946000132 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 909946000133 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 909946000134 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 909946000135 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 909946000136 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 909946000137 active site 909946000138 tetramer interface [polypeptide binding]; other site 909946000139 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 909946000140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946000141 active site 909946000142 phosphorylation site [posttranslational modification] 909946000143 intermolecular recognition site; other site 909946000144 dimerization interface [polypeptide binding]; other site 909946000145 Transcriptional regulator; Region: CitT; pfam12431 909946000146 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 909946000147 PAS domain; Region: PAS; smart00091 909946000148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946000149 ATP binding site [chemical binding]; other site 909946000150 Mg2+ binding site [ion binding]; other site 909946000151 G-X-G motif; other site 909946000152 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 909946000153 oxaloacetate decarboxylase; Provisional; Region: PRK14040 909946000154 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 909946000155 active site 909946000156 catalytic residues [active] 909946000157 metal binding site [ion binding]; metal-binding site 909946000158 homodimer binding site [polypeptide binding]; other site 909946000159 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 909946000160 carboxyltransferase (CT) interaction site; other site 909946000161 biotinylation site [posttranslational modification]; other site 909946000162 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 909946000163 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 909946000164 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 909946000165 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 909946000166 putative active site [active] 909946000167 (T/H)XGH motif; other site 909946000168 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 909946000169 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 909946000170 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 909946000171 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 909946000172 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 909946000173 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 909946000174 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 909946000175 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 909946000176 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 909946000177 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 909946000178 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 909946000179 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 909946000180 catalytic site [active] 909946000181 subunit interface [polypeptide binding]; other site 909946000182 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 909946000183 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 909946000184 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 909946000185 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 909946000186 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 909946000187 ATP-grasp domain; Region: ATP-grasp_4; cl17255 909946000188 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 909946000189 IMP binding site; other site 909946000190 dimer interface [polypeptide binding]; other site 909946000191 interdomain contacts; other site 909946000192 partial ornithine binding site; other site 909946000193 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 909946000194 carnitine operon protein CaiE; Provisional; Region: PRK13627 909946000195 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 909946000196 putative trimer interface [polypeptide binding]; other site 909946000197 putative metal binding site [ion binding]; other site 909946000198 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 909946000199 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 909946000200 substrate binding site [chemical binding]; other site 909946000201 oxyanion hole (OAH) forming residues; other site 909946000202 trimer interface [polypeptide binding]; other site 909946000203 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 909946000204 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 909946000205 acyl-activating enzyme (AAE) consensus motif; other site 909946000206 putative AMP binding site [chemical binding]; other site 909946000207 putative active site [active] 909946000208 putative CoA binding site [chemical binding]; other site 909946000209 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 909946000210 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 909946000211 active site 909946000212 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 909946000213 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 909946000214 Ligand binding site [chemical binding]; other site 909946000215 Electron transfer flavoprotein domain; Region: ETF; pfam01012 909946000216 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 909946000217 Electron transfer flavoprotein domain; Region: ETF; smart00893 909946000218 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 909946000219 putative oxidoreductase FixC; Provisional; Region: PRK10157 909946000220 ferredoxin-like protein FixX; Provisional; Region: PRK15449 909946000221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946000222 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 909946000223 putative substrate translocation pore; other site 909946000224 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 909946000225 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 909946000226 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 909946000227 Sulfatase; Region: Sulfatase; cl17466 909946000228 Sulfatase; Region: Sulfatase; cl17466 909946000229 Sulfatase; Region: Sulfatase; cl17466 909946000230 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 909946000231 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 909946000232 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 909946000233 TrkA-N domain; Region: TrkA_N; pfam02254 909946000234 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 909946000235 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 909946000236 folate binding site [chemical binding]; other site 909946000237 NADP+ binding site [chemical binding]; other site 909946000238 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 909946000239 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 909946000240 active site 909946000241 metal binding site [ion binding]; metal-binding site 909946000242 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 909946000243 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 909946000244 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 909946000245 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 909946000246 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 909946000247 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 909946000248 SurA N-terminal domain; Region: SurA_N; pfam09312 909946000249 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 909946000250 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 909946000251 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 909946000252 OstA-like protein; Region: OstA; pfam03968 909946000253 Organic solvent tolerance protein; Region: OstA_C; pfam04453 909946000254 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 909946000255 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 909946000256 putative metal binding site [ion binding]; other site 909946000257 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 909946000258 HSP70 interaction site [polypeptide binding]; other site 909946000259 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 909946000260 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 909946000261 active site 909946000262 ATP-dependent helicase HepA; Validated; Region: PRK04914 909946000263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909946000264 ATP binding site [chemical binding]; other site 909946000265 putative Mg++ binding site [ion binding]; other site 909946000266 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946000267 nucleotide binding region [chemical binding]; other site 909946000268 ATP-binding site [chemical binding]; other site 909946000269 DNA polymerase II; Reviewed; Region: PRK05762 909946000270 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 909946000271 active site 909946000272 catalytic site [active] 909946000273 substrate binding site [chemical binding]; other site 909946000274 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 909946000275 active site 909946000276 metal-binding site 909946000277 Uncharacterized conserved protein [Function unknown]; Region: COG1434 909946000278 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 909946000279 putative active site [active] 909946000280 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 909946000281 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 909946000282 intersubunit interface [polypeptide binding]; other site 909946000283 active site 909946000284 Zn2+ binding site [ion binding]; other site 909946000285 L-arabinose isomerase; Provisional; Region: PRK02929 909946000286 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 909946000287 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 909946000288 trimer interface [polypeptide binding]; other site 909946000289 putative substrate binding site [chemical binding]; other site 909946000290 putative metal binding site [ion binding]; other site 909946000291 ribulokinase; Provisional; Region: PRK04123 909946000292 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 909946000293 N- and C-terminal domain interface [polypeptide binding]; other site 909946000294 active site 909946000295 MgATP binding site [chemical binding]; other site 909946000296 catalytic site [active] 909946000297 metal binding site [ion binding]; metal-binding site 909946000298 carbohydrate binding site [chemical binding]; other site 909946000299 homodimer interface [polypeptide binding]; other site 909946000300 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 909946000301 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 909946000302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946000303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946000304 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 909946000305 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 909946000306 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 909946000307 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 909946000308 Walker A/P-loop; other site 909946000309 ATP binding site [chemical binding]; other site 909946000310 Q-loop/lid; other site 909946000311 ABC transporter signature motif; other site 909946000312 Walker B; other site 909946000313 D-loop; other site 909946000314 H-loop/switch region; other site 909946000315 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 909946000316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946000317 dimer interface [polypeptide binding]; other site 909946000318 conserved gate region; other site 909946000319 putative PBP binding loops; other site 909946000320 ABC-ATPase subunit interface; other site 909946000321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946000322 dimer interface [polypeptide binding]; other site 909946000323 conserved gate region; other site 909946000324 putative PBP binding loops; other site 909946000325 ABC-ATPase subunit interface; other site 909946000326 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 909946000327 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 909946000328 transcriptional regulator SgrR; Provisional; Region: PRK13626 909946000329 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 909946000330 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 909946000331 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 909946000332 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 909946000333 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 909946000334 substrate binding site [chemical binding]; other site 909946000335 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 909946000336 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 909946000337 substrate binding site [chemical binding]; other site 909946000338 ligand binding site [chemical binding]; other site 909946000339 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 909946000340 tartrate dehydrogenase; Region: TTC; TIGR02089 909946000341 2-isopropylmalate synthase; Validated; Region: PRK00915 909946000342 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 909946000343 active site 909946000344 catalytic residues [active] 909946000345 metal binding site [ion binding]; metal-binding site 909946000346 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 909946000347 leu operon leader peptide; Provisional; Region: PRK14744 909946000348 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 909946000349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946000350 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 909946000351 putative substrate binding pocket [chemical binding]; other site 909946000352 putative dimerization interface [polypeptide binding]; other site 909946000353 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 909946000354 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 909946000355 PYR/PP interface [polypeptide binding]; other site 909946000356 dimer interface [polypeptide binding]; other site 909946000357 TPP binding site [chemical binding]; other site 909946000358 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 909946000359 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 909946000360 TPP-binding site [chemical binding]; other site 909946000361 dimer interface [polypeptide binding]; other site 909946000362 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 909946000363 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 909946000364 putative valine binding site [chemical binding]; other site 909946000365 dimer interface [polypeptide binding]; other site 909946000366 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 909946000367 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 909946000368 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946000369 DNA binding site [nucleotide binding] 909946000370 domain linker motif; other site 909946000371 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 909946000372 dimerization interface [polypeptide binding]; other site 909946000373 ligand binding site [chemical binding]; other site 909946000374 mraZ protein; Region: TIGR00242 909946000375 MraZ protein; Region: MraZ; pfam02381 909946000376 MraZ protein; Region: MraZ; pfam02381 909946000377 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 909946000378 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 909946000379 cell division protein FtsL; Provisional; Region: PRK10772 909946000380 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 909946000381 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 909946000382 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 909946000383 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 909946000384 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 909946000385 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 909946000386 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 909946000387 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 909946000388 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 909946000389 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 909946000390 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 909946000391 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 909946000392 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 909946000393 Mg++ binding site [ion binding]; other site 909946000394 putative catalytic motif [active] 909946000395 putative substrate binding site [chemical binding]; other site 909946000396 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 909946000397 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 909946000398 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 909946000399 cell division protein FtsW; Provisional; Region: PRK10774 909946000400 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 909946000401 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 909946000402 active site 909946000403 homodimer interface [polypeptide binding]; other site 909946000404 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 909946000405 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 909946000406 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 909946000407 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 909946000408 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 909946000409 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 909946000410 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 909946000411 cell division protein FtsQ; Provisional; Region: PRK10775 909946000412 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 909946000413 Cell division protein FtsQ; Region: FtsQ; pfam03799 909946000414 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 909946000415 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 909946000416 Cell division protein FtsA; Region: FtsA; pfam14450 909946000417 cell division protein FtsZ; Validated; Region: PRK09330 909946000418 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 909946000419 nucleotide binding site [chemical binding]; other site 909946000420 SulA interaction site; other site 909946000421 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 909946000422 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 909946000423 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 909946000424 SecA regulator SecM; Provisional; Region: PRK02943 909946000425 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 909946000426 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 909946000427 SEC-C motif; Region: SEC-C; pfam02810 909946000428 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 909946000429 active site 909946000430 8-oxo-dGMP binding site [chemical binding]; other site 909946000431 nudix motif; other site 909946000432 metal binding site [ion binding]; metal-binding site 909946000433 DNA gyrase inhibitor; Reviewed; Region: PRK00418 909946000434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 909946000435 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 909946000436 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 909946000437 CoA-binding site [chemical binding]; other site 909946000438 ATP-binding [chemical binding]; other site 909946000439 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 909946000440 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 909946000441 active site 909946000442 type IV pilin biogenesis protein; Provisional; Region: PRK10573 909946000443 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 909946000444 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 909946000445 hypothetical protein; Provisional; Region: PRK10436 909946000446 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 909946000447 Walker A motif; other site 909946000448 ATP binding site [chemical binding]; other site 909946000449 Walker B motif; other site 909946000450 putative major pilin subunit; Provisional; Region: PRK10574 909946000451 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 909946000452 Pilin (bacterial filament); Region: Pilin; pfam00114 909946000453 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 909946000454 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 909946000455 dimerization interface [polypeptide binding]; other site 909946000456 active site 909946000457 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 909946000458 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 909946000459 amidase catalytic site [active] 909946000460 Zn binding residues [ion binding]; other site 909946000461 substrate binding site [chemical binding]; other site 909946000462 regulatory protein AmpE; Provisional; Region: PRK10987 909946000463 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 909946000464 active site 909946000465 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 909946000466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946000467 putative substrate translocation pore; other site 909946000468 aromatic amino acid transporter; Provisional; Region: PRK10238 909946000469 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 909946000470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946000471 DNA-binding site [nucleotide binding]; DNA binding site 909946000472 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 909946000473 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 909946000474 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 909946000475 dimer interface [polypeptide binding]; other site 909946000476 TPP-binding site [chemical binding]; other site 909946000477 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 909946000478 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 909946000479 E3 interaction surface; other site 909946000480 lipoyl attachment site [posttranslational modification]; other site 909946000481 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 909946000482 E3 interaction surface; other site 909946000483 lipoyl attachment site [posttranslational modification]; other site 909946000484 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 909946000485 E3 interaction surface; other site 909946000486 lipoyl attachment site [posttranslational modification]; other site 909946000487 e3 binding domain; Region: E3_binding; pfam02817 909946000488 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 909946000489 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 909946000490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 909946000491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909946000492 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 909946000493 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 909946000494 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 909946000495 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 909946000496 substrate binding site [chemical binding]; other site 909946000497 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 909946000498 substrate binding site [chemical binding]; other site 909946000499 ligand binding site [chemical binding]; other site 909946000500 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 909946000501 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 909946000502 hypothetical protein; Provisional; Region: PRK05248 909946000503 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 909946000504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 909946000505 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 909946000506 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 909946000507 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909946000508 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 909946000509 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946000510 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 909946000511 spermidine synthase; Provisional; Region: PRK00811 909946000512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946000513 S-adenosylmethionine binding site [chemical binding]; other site 909946000514 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 909946000515 multicopper oxidase; Provisional; Region: PRK10965 909946000516 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 909946000517 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 909946000518 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 909946000519 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 909946000520 Trp docking motif [polypeptide binding]; other site 909946000521 putative active site [active] 909946000522 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 909946000523 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909946000524 active site 909946000525 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 909946000526 active site clefts [active] 909946000527 zinc binding site [ion binding]; other site 909946000528 dimer interface [polypeptide binding]; other site 909946000529 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 909946000530 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 909946000531 Walker A/P-loop; other site 909946000532 ATP binding site [chemical binding]; other site 909946000533 Q-loop/lid; other site 909946000534 ABC transporter signature motif; other site 909946000535 Walker B; other site 909946000536 D-loop; other site 909946000537 H-loop/switch region; other site 909946000538 inner membrane transport permease; Provisional; Region: PRK15066 909946000539 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 909946000540 putative fimbrial protein StiH; Provisional; Region: PRK15297 909946000541 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 909946000542 PapC N-terminal domain; Region: PapC_N; pfam13954 909946000543 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 909946000544 PapC C-terminal domain; Region: PapC_C; pfam13953 909946000545 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 909946000546 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946000547 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946000548 fimbrial protein StiA; Provisional; Region: PRK15300 909946000549 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 909946000550 active pocket/dimerization site; other site 909946000551 active site 909946000552 phosphorylation site [posttranslational modification] 909946000553 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 909946000554 putative active site [active] 909946000555 putative metal binding site [ion binding]; other site 909946000556 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 909946000557 tetramerization interface [polypeptide binding]; other site 909946000558 active site 909946000559 Pantoate-beta-alanine ligase; Region: PanC; cd00560 909946000560 pantoate--beta-alanine ligase; Region: panC; TIGR00018 909946000561 active site 909946000562 ATP-binding site [chemical binding]; other site 909946000563 pantoate-binding site; other site 909946000564 HXXH motif; other site 909946000565 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 909946000566 oligomerization interface [polypeptide binding]; other site 909946000567 active site 909946000568 metal binding site [ion binding]; metal-binding site 909946000569 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 909946000570 catalytic center binding site [active] 909946000571 ATP binding site [chemical binding]; other site 909946000572 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 909946000573 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 909946000574 active site 909946000575 NTP binding site [chemical binding]; other site 909946000576 metal binding triad [ion binding]; metal-binding site 909946000577 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 909946000578 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 909946000579 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 909946000580 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 909946000581 active site 909946000582 nucleotide binding site [chemical binding]; other site 909946000583 HIGH motif; other site 909946000584 KMSKS motif; other site 909946000585 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 909946000586 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 909946000587 2'-5' RNA ligase; Provisional; Region: PRK15124 909946000588 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 909946000589 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 909946000590 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 909946000591 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909946000592 ATP binding site [chemical binding]; other site 909946000593 putative Mg++ binding site [ion binding]; other site 909946000594 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946000595 nucleotide binding region [chemical binding]; other site 909946000596 ATP-binding site [chemical binding]; other site 909946000597 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 909946000598 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 909946000599 Transglycosylase; Region: Transgly; pfam00912 909946000600 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 909946000601 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 909946000602 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 909946000603 N-terminal plug; other site 909946000604 ligand-binding site [chemical binding]; other site 909946000605 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 909946000606 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 909946000607 Walker A/P-loop; other site 909946000608 ATP binding site [chemical binding]; other site 909946000609 Q-loop/lid; other site 909946000610 ABC transporter signature motif; other site 909946000611 Walker B; other site 909946000612 D-loop; other site 909946000613 H-loop/switch region; other site 909946000614 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 909946000615 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 909946000616 siderophore binding site; other site 909946000617 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 909946000618 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909946000619 ABC-ATPase subunit interface; other site 909946000620 dimer interface [polypeptide binding]; other site 909946000621 putative PBP binding regions; other site 909946000622 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909946000623 ABC-ATPase subunit interface; other site 909946000624 dimer interface [polypeptide binding]; other site 909946000625 putative PBP binding regions; other site 909946000626 putative fimbrial subunit StfA; Provisional; Region: PRK15283 909946000627 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 909946000628 PapC N-terminal domain; Region: PapC_N; pfam13954 909946000629 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 909946000630 PapC C-terminal domain; Region: PapC_C; pfam13953 909946000631 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 909946000632 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946000633 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946000634 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 909946000635 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 909946000636 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 909946000637 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 909946000638 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 909946000639 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 909946000640 inhibitor-cofactor binding pocket; inhibition site 909946000641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946000642 catalytic residue [active] 909946000643 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 909946000644 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 909946000645 Cl- selectivity filter; other site 909946000646 Cl- binding residues [ion binding]; other site 909946000647 pore gating glutamate residue; other site 909946000648 dimer interface [polypeptide binding]; other site 909946000649 H+/Cl- coupling transport residue; other site 909946000650 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 909946000651 hypothetical protein; Provisional; Region: PRK10578 909946000652 UPF0126 domain; Region: UPF0126; pfam03458 909946000653 UPF0126 domain; Region: UPF0126; pfam03458 909946000654 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 909946000655 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 909946000656 cobalamin binding residues [chemical binding]; other site 909946000657 putative BtuC binding residues; other site 909946000658 dimer interface [polypeptide binding]; other site 909946000659 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 909946000660 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 909946000661 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 909946000662 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 909946000663 Zn2+ binding site [ion binding]; other site 909946000664 Mg2+ binding site [ion binding]; other site 909946000665 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 909946000666 serine endoprotease; Provisional; Region: PRK10942 909946000667 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 909946000668 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 909946000669 protein binding site [polypeptide binding]; other site 909946000670 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 909946000671 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 909946000672 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 909946000673 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 909946000674 hypothetical protein; Provisional; Region: PRK13677 909946000675 shikimate transporter; Provisional; Region: PRK09952 909946000676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946000677 putative substrate translocation pore; other site 909946000678 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 909946000679 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 909946000680 trimer interface [polypeptide binding]; other site 909946000681 active site 909946000682 substrate binding site [chemical binding]; other site 909946000683 CoA binding site [chemical binding]; other site 909946000684 PII uridylyl-transferase; Provisional; Region: PRK05007 909946000685 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 909946000686 metal binding triad; other site 909946000687 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 909946000688 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 909946000689 Zn2+ binding site [ion binding]; other site 909946000690 Mg2+ binding site [ion binding]; other site 909946000691 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 909946000692 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 909946000693 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 909946000694 active site 909946000695 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 909946000696 rRNA interaction site [nucleotide binding]; other site 909946000697 S8 interaction site; other site 909946000698 putative laminin-1 binding site; other site 909946000699 elongation factor Ts; Provisional; Region: tsf; PRK09377 909946000700 UBA/TS-N domain; Region: UBA; pfam00627 909946000701 Elongation factor TS; Region: EF_TS; pfam00889 909946000702 Elongation factor TS; Region: EF_TS; pfam00889 909946000703 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 909946000704 putative nucleotide binding site [chemical binding]; other site 909946000705 uridine monophosphate binding site [chemical binding]; other site 909946000706 homohexameric interface [polypeptide binding]; other site 909946000707 ribosome recycling factor; Reviewed; Region: frr; PRK00083 909946000708 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 909946000709 hinge region; other site 909946000710 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 909946000711 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 909946000712 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 909946000713 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 909946000714 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 909946000715 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 909946000716 catalytic residue [active] 909946000717 putative FPP diphosphate binding site; other site 909946000718 putative FPP binding hydrophobic cleft; other site 909946000719 dimer interface [polypeptide binding]; other site 909946000720 putative IPP diphosphate binding site; other site 909946000721 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 909946000722 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 909946000723 zinc metallopeptidase RseP; Provisional; Region: PRK10779 909946000724 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 909946000725 active site 909946000726 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 909946000727 protein binding site [polypeptide binding]; other site 909946000728 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 909946000729 protein binding site [polypeptide binding]; other site 909946000730 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 909946000731 putative substrate binding region [chemical binding]; other site 909946000732 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 909946000733 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 909946000734 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 909946000735 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 909946000736 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 909946000737 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 909946000738 Surface antigen; Region: Bac_surface_Ag; pfam01103 909946000739 periplasmic chaperone; Provisional; Region: PRK10780 909946000740 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 909946000741 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 909946000742 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 909946000743 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 909946000744 trimer interface [polypeptide binding]; other site 909946000745 active site 909946000746 UDP-GlcNAc binding site [chemical binding]; other site 909946000747 lipid binding site [chemical binding]; lipid-binding site 909946000748 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 909946000749 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 909946000750 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 909946000751 active site 909946000752 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 909946000753 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 909946000754 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 909946000755 RNA/DNA hybrid binding site [nucleotide binding]; other site 909946000756 active site 909946000757 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 909946000758 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 909946000759 putative active site [active] 909946000760 putative PHP Thumb interface [polypeptide binding]; other site 909946000761 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 909946000762 generic binding surface II; other site 909946000763 generic binding surface I; other site 909946000764 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 909946000765 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 909946000766 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 909946000767 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 909946000768 putative sugar binding site [chemical binding]; other site 909946000769 catalytic residues [active] 909946000770 PKD domain; Region: PKD; pfam00801 909946000771 lysine decarboxylase LdcC; Provisional; Region: PRK15399 909946000772 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 909946000773 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 909946000774 homodimer interface [polypeptide binding]; other site 909946000775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946000776 catalytic residue [active] 909946000777 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 909946000778 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 909946000779 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 909946000780 putative metal binding site [ion binding]; other site 909946000781 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 909946000782 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 909946000783 Ligand Binding Site [chemical binding]; other site 909946000784 TilS substrate binding domain; Region: TilS; pfam09179 909946000785 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 909946000786 Rho-binding antiterminator; Provisional; Region: PRK11625 909946000787 hypothetical protein; Provisional; Region: PRK04964 909946000788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 909946000789 hypothetical protein; Provisional; Region: PRK09256 909946000790 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 909946000791 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 909946000792 NlpE N-terminal domain; Region: NlpE; pfam04170 909946000793 prolyl-tRNA synthetase; Provisional; Region: PRK09194 909946000794 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 909946000795 dimer interface [polypeptide binding]; other site 909946000796 motif 1; other site 909946000797 active site 909946000798 motif 2; other site 909946000799 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 909946000800 putative deacylase active site [active] 909946000801 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 909946000802 active site 909946000803 motif 3; other site 909946000804 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 909946000805 anticodon binding site; other site 909946000806 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 909946000807 homodimer interaction site [polypeptide binding]; other site 909946000808 cofactor binding site; other site 909946000809 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 909946000810 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 909946000811 lipoprotein, YaeC family; Region: TIGR00363 909946000812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946000813 dimer interface [polypeptide binding]; other site 909946000814 conserved gate region; other site 909946000815 ABC-ATPase subunit interface; other site 909946000816 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 909946000817 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 909946000818 Walker A/P-loop; other site 909946000819 ATP binding site [chemical binding]; other site 909946000820 Q-loop/lid; other site 909946000821 ABC transporter signature motif; other site 909946000822 Walker B; other site 909946000823 D-loop; other site 909946000824 H-loop/switch region; other site 909946000825 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 909946000826 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 909946000827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946000828 active site 909946000829 motif I; other site 909946000830 motif II; other site 909946000831 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909946000832 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909946000833 active site 909946000834 catalytic tetrad [active] 909946000835 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946000836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946000837 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 909946000838 putative effector binding pocket; other site 909946000839 dimerization interface [polypeptide binding]; other site 909946000840 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 909946000841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946000842 putative substrate translocation pore; other site 909946000843 hypothetical protein; Provisional; Region: PRK05421 909946000844 putative catalytic site [active] 909946000845 putative metal binding site [ion binding]; other site 909946000846 putative phosphate binding site [ion binding]; other site 909946000847 putative catalytic site [active] 909946000848 putative phosphate binding site [ion binding]; other site 909946000849 putative metal binding site [ion binding]; other site 909946000850 Methyltransferase domain; Region: Methyltransf_23; pfam13489 909946000851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946000852 S-adenosylmethionine binding site [chemical binding]; other site 909946000853 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 909946000854 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 909946000855 N-acetyl-D-glucosamine binding site [chemical binding]; other site 909946000856 catalytic residue [active] 909946000857 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 909946000858 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 909946000859 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 909946000860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946000861 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 909946000862 RNA/DNA hybrid binding site [nucleotide binding]; other site 909946000863 active site 909946000864 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 909946000865 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 909946000866 active site 909946000867 catalytic site [active] 909946000868 substrate binding site [chemical binding]; other site 909946000869 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 909946000870 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 909946000871 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 909946000872 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 909946000873 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 909946000874 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 909946000875 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 909946000876 ImpE protein; Region: ImpE; pfam07024 909946000877 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 909946000878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946000879 Walker A motif; other site 909946000880 ATP binding site [chemical binding]; other site 909946000881 Walker B motif; other site 909946000882 arginine finger; other site 909946000883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946000884 Walker A motif; other site 909946000885 ATP binding site [chemical binding]; other site 909946000886 Walker B motif; other site 909946000887 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 909946000888 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 909946000889 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 909946000890 Protein of unknown function (DUF877); Region: DUF877; pfam05943 909946000891 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 909946000892 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 909946000893 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 909946000894 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 909946000895 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 909946000896 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 909946000897 hypothetical protein; Provisional; Region: PRK08126 909946000898 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 909946000899 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 909946000900 ligand binding site [chemical binding]; other site 909946000901 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 909946000902 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 909946000903 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 909946000904 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 909946000905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 909946000906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 909946000907 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 909946000908 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 909946000909 Uncharacterized conserved protein [Function unknown]; Region: COG5435 909946000910 PAAR motif; Region: PAAR_motif; pfam05488 909946000911 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 909946000912 RHS Repeat; Region: RHS_repeat; pfam05593 909946000913 RHS Repeat; Region: RHS_repeat; pfam05593 909946000914 RHS protein; Region: RHS; pfam03527 909946000915 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 909946000916 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 909946000917 RHS protein; Region: RHS; pfam03527 909946000918 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 909946000919 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 909946000920 Transposase; Region: HTH_Tnp_1; cl17663 909946000921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 909946000922 Integrase core domain; Region: rve_3; pfam13683 909946000923 Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221 909946000924 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 909946000925 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946000926 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946000927 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 909946000928 PapC N-terminal domain; Region: PapC_N; pfam13954 909946000929 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 909946000930 PapC C-terminal domain; Region: PapC_C; pfam13953 909946000931 putative pilin structural protein SafD; Provisional; Region: PRK15222 909946000932 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 909946000933 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 909946000934 putative active site [active] 909946000935 putative metal binding site [ion binding]; other site 909946000936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946000937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946000938 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 909946000939 dimerization interface [polypeptide binding]; other site 909946000940 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 909946000941 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 909946000942 dimer interface [polypeptide binding]; other site 909946000943 C-N hydrolase family amidase; Provisional; Region: PRK10438 909946000944 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 909946000945 putative active site [active] 909946000946 catalytic triad [active] 909946000947 dimer interface [polypeptide binding]; other site 909946000948 multimer interface [polypeptide binding]; other site 909946000949 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 909946000950 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 909946000951 active site 909946000952 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 909946000953 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 909946000954 dimer interface [polypeptide binding]; other site 909946000955 active site 909946000956 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 909946000957 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 909946000958 putative active site [active] 909946000959 putative dimer interface [polypeptide binding]; other site 909946000960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 909946000961 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 909946000962 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 909946000963 active site 909946000964 DNA polymerase IV; Validated; Region: PRK02406 909946000965 DNA binding site [nucleotide binding] 909946000966 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 909946000967 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 909946000968 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 909946000969 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 909946000970 metal binding site [ion binding]; metal-binding site 909946000971 dimer interface [polypeptide binding]; other site 909946000972 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909946000973 active site 909946000974 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 909946000975 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 909946000976 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 909946000977 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 909946000978 trimer interface [polypeptide binding]; other site 909946000979 eyelet of channel; other site 909946000980 gamma-glutamyl kinase; Provisional; Region: PRK05429 909946000981 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 909946000982 nucleotide binding site [chemical binding]; other site 909946000983 homotetrameric interface [polypeptide binding]; other site 909946000984 putative phosphate binding site [ion binding]; other site 909946000985 putative allosteric binding site; other site 909946000986 PUA domain; Region: PUA; pfam01472 909946000987 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 909946000988 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 909946000989 putative catalytic cysteine [active] 909946000990 HTH-like domain; Region: HTH_21; pfam13276 909946000991 Integrase core domain; Region: rve; pfam00665 909946000992 Integrase core domain; Region: rve_2; pfam13333 909946000993 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 909946000994 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 909946000995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946000996 putative substrate translocation pore; other site 909946000997 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 909946000998 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 909946000999 hypothetical protein; Provisional; Region: PRK14812 909946001000 substrate binding site [chemical binding]; other site 909946001001 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 909946001002 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 909946001003 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 909946001004 transcriptional activator TtdR; Provisional; Region: PRK09801 909946001005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946001006 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 909946001007 putative effector binding pocket; other site 909946001008 putative dimerization interface [polypeptide binding]; other site 909946001009 YjzC-like protein; Region: YjzC; pfam14168 909946001010 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 909946001011 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946001012 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946001013 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 909946001014 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 909946001015 PapC N-terminal domain; Region: PapC_N; pfam13954 909946001016 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 909946001017 PapC C-terminal domain; Region: PapC_C; pfam13953 909946001018 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 909946001019 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946001020 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946001021 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 909946001022 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 909946001023 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 909946001024 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946001025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 909946001026 DNA binding site [nucleotide binding] 909946001027 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 909946001028 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 909946001029 DNA binding residues [nucleotide binding] 909946001030 dimerization interface [polypeptide binding]; other site 909946001031 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 909946001032 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 909946001033 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 909946001034 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 909946001035 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 909946001036 HlyD family secretion protein; Region: HlyD_3; pfam13437 909946001037 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 909946001038 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 909946001039 metal-binding site [ion binding] 909946001040 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 909946001041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946001042 motif II; other site 909946001043 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 909946001044 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 909946001045 DNA binding residues [nucleotide binding] 909946001046 dimer interface [polypeptide binding]; other site 909946001047 copper binding site [ion binding]; other site 909946001048 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 909946001049 metal-binding site [ion binding] 909946001050 putative sialic acid transporter; Region: 2A0112; TIGR00891 909946001051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946001052 putative substrate translocation pore; other site 909946001053 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 909946001054 DNA methylase; Region: N6_N4_Mtase; cl17433 909946001055 DNA methylase; Region: N6_N4_Mtase; pfam01555 909946001056 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 909946001057 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 909946001058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 909946001059 VRR-NUC domain; Region: VRR_NUC; pfam08774 909946001060 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 909946001061 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 909946001062 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 909946001063 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 909946001064 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 909946001065 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 909946001066 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 909946001067 N-terminal plug; other site 909946001068 ligand-binding site [chemical binding]; other site 909946001069 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 909946001070 hypothetical protein; Provisional; Region: PRK09929 909946001071 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 909946001072 Propionate catabolism activator; Region: PrpR_N; pfam06506 909946001073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946001074 Walker A motif; other site 909946001075 ATP binding site [chemical binding]; other site 909946001076 Walker B motif; other site 909946001077 arginine finger; other site 909946001078 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 909946001079 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 909946001080 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 909946001081 tetramer interface [polypeptide binding]; other site 909946001082 active site 909946001083 Mg2+/Mn2+ binding site [ion binding]; other site 909946001084 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 909946001085 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 909946001086 dimer interface [polypeptide binding]; other site 909946001087 active site 909946001088 citrylCoA binding site [chemical binding]; other site 909946001089 oxalacetate/citrate binding site [chemical binding]; other site 909946001090 coenzyme A binding site [chemical binding]; other site 909946001091 catalytic triad [active] 909946001092 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 909946001093 2-methylcitrate dehydratase; Region: prpD; TIGR02330 909946001094 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 909946001095 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 909946001096 acyl-activating enzyme (AAE) consensus motif; other site 909946001097 AMP binding site [chemical binding]; other site 909946001098 active site 909946001099 CoA binding site [chemical binding]; other site 909946001100 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 909946001101 dimer interface [polypeptide binding]; other site 909946001102 active site 909946001103 Schiff base residues; other site 909946001104 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 909946001105 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 909946001106 Autotransporter beta-domain; Region: Autotransporter; pfam03797 909946001107 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 909946001108 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 909946001109 ligand binding site [chemical binding]; other site 909946001110 flexible hinge region; other site 909946001111 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 909946001112 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 909946001113 microcin B17 transporter; Reviewed; Region: PRK11098 909946001114 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 909946001115 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 909946001116 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 909946001117 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 909946001118 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 909946001119 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 909946001120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 909946001121 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 909946001122 drug efflux system protein MdtG; Provisional; Region: PRK09874 909946001123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946001124 putative substrate translocation pore; other site 909946001125 anti-RssB factor; Provisional; Region: PRK10244 909946001126 hypothetical protein; Provisional; Region: PRK11505 909946001127 psiF repeat; Region: PsiF_repeat; pfam07769 909946001128 psiF repeat; Region: PsiF_repeat; pfam07769 909946001129 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 909946001130 MASE2 domain; Region: MASE2; pfam05230 909946001131 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 909946001132 metal binding site [ion binding]; metal-binding site 909946001133 active site 909946001134 I-site; other site 909946001135 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 909946001136 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 909946001137 hypothetical protein; Validated; Region: PRK00124 909946001138 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 909946001139 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 909946001140 ADP binding site [chemical binding]; other site 909946001141 magnesium binding site [ion binding]; other site 909946001142 putative shikimate binding site; other site 909946001143 hypothetical protein; Provisional; Region: PRK10380 909946001144 hypothetical protein; Provisional; Region: PRK10481 909946001145 hypothetical protein; Provisional; Region: PRK10579 909946001146 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 909946001147 fructokinase; Reviewed; Region: PRK09557 909946001148 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 909946001149 nucleotide binding site [chemical binding]; other site 909946001150 MFS transport protein AraJ; Provisional; Region: PRK10091 909946001151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946001152 putative substrate translocation pore; other site 909946001153 exonuclease subunit SbcC; Provisional; Region: PRK10246 909946001154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946001155 Walker A/P-loop; other site 909946001156 ATP binding site [chemical binding]; other site 909946001157 Q-loop/lid; other site 909946001158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946001159 ABC transporter signature motif; other site 909946001160 Walker B; other site 909946001161 D-loop; other site 909946001162 H-loop/switch region; other site 909946001163 exonuclease subunit SbcD; Provisional; Region: PRK10966 909946001164 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 909946001165 active site 909946001166 metal binding site [ion binding]; metal-binding site 909946001167 DNA binding site [nucleotide binding] 909946001168 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 909946001169 transcriptional regulator PhoB; Provisional; Region: PRK10161 909946001170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946001171 active site 909946001172 phosphorylation site [posttranslational modification] 909946001173 intermolecular recognition site; other site 909946001174 dimerization interface [polypeptide binding]; other site 909946001175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946001176 DNA binding site [nucleotide binding] 909946001177 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 909946001178 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 909946001179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 909946001180 putative active site [active] 909946001181 heme pocket [chemical binding]; other site 909946001182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946001183 dimer interface [polypeptide binding]; other site 909946001184 phosphorylation site [posttranslational modification] 909946001185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946001186 ATP binding site [chemical binding]; other site 909946001187 Mg2+ binding site [ion binding]; other site 909946001188 G-X-G motif; other site 909946001189 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 909946001190 putative proline-specific permease; Provisional; Region: proY; PRK10580 909946001191 maltodextrin glucosidase; Provisional; Region: PRK10785 909946001192 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 909946001193 homodimer interface [polypeptide binding]; other site 909946001194 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 909946001195 active site 909946001196 homodimer interface [polypeptide binding]; other site 909946001197 catalytic site [active] 909946001198 peroxidase; Provisional; Region: PRK15000 909946001199 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 909946001200 dimer interface [polypeptide binding]; other site 909946001201 decamer (pentamer of dimers) interface [polypeptide binding]; other site 909946001202 catalytic triad [active] 909946001203 peroxidatic and resolving cysteines [active] 909946001204 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 909946001205 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 909946001206 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 909946001207 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 909946001208 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 909946001209 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 909946001210 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 909946001211 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 909946001212 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 909946001213 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 909946001214 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 909946001215 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 909946001216 Protein export membrane protein; Region: SecD_SecF; pfam02355 909946001217 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 909946001218 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 909946001219 Predicted transcriptional regulator [Transcription]; Region: COG2378 909946001220 HTH domain; Region: HTH_11; pfam08279 909946001221 WYL domain; Region: WYL; pfam13280 909946001222 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 909946001223 active site 909946001224 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 909946001225 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 909946001226 hypothetical protein; Provisional; Region: PRK11530 909946001227 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 909946001228 ATP cone domain; Region: ATP-cone; pfam03477 909946001229 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 909946001230 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 909946001231 catalytic motif [active] 909946001232 Zn binding site [ion binding]; other site 909946001233 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 909946001234 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 909946001235 homopentamer interface [polypeptide binding]; other site 909946001236 active site 909946001237 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 909946001238 putative RNA binding site [nucleotide binding]; other site 909946001239 thiamine monophosphate kinase; Provisional; Region: PRK05731 909946001240 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 909946001241 ATP binding site [chemical binding]; other site 909946001242 dimerization interface [polypeptide binding]; other site 909946001243 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 909946001244 tetramer interfaces [polypeptide binding]; other site 909946001245 binuclear metal-binding site [ion binding]; other site 909946001246 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909946001247 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909946001248 active site 909946001249 catalytic tetrad [active] 909946001250 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 909946001251 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 909946001252 TPP-binding site; other site 909946001253 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 909946001254 PYR/PP interface [polypeptide binding]; other site 909946001255 dimer interface [polypeptide binding]; other site 909946001256 TPP binding site [chemical binding]; other site 909946001257 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 909946001258 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 909946001259 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 909946001260 substrate binding pocket [chemical binding]; other site 909946001261 chain length determination region; other site 909946001262 substrate-Mg2+ binding site; other site 909946001263 catalytic residues [active] 909946001264 aspartate-rich region 1; other site 909946001265 active site lid residues [active] 909946001266 aspartate-rich region 2; other site 909946001267 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 909946001268 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 909946001269 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 909946001270 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 909946001271 Ligand Binding Site [chemical binding]; other site 909946001272 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 909946001273 active site residue [active] 909946001274 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 909946001275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946001276 dimer interface [polypeptide binding]; other site 909946001277 conserved gate region; other site 909946001278 ABC-ATPase subunit interface; other site 909946001279 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 909946001280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946001281 dimer interface [polypeptide binding]; other site 909946001282 conserved gate region; other site 909946001283 putative PBP binding loops; other site 909946001284 ABC-ATPase subunit interface; other site 909946001285 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 909946001286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946001287 Walker A/P-loop; other site 909946001288 ATP binding site [chemical binding]; other site 909946001289 Q-loop/lid; other site 909946001290 ABC transporter signature motif; other site 909946001291 Walker B; other site 909946001292 D-loop; other site 909946001293 H-loop/switch region; other site 909946001294 TOBE domain; Region: TOBE_2; pfam08402 909946001295 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 909946001296 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 909946001297 transcriptional regulator protein; Region: phnR; TIGR03337 909946001298 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946001299 DNA-binding site [nucleotide binding]; DNA binding site 909946001300 UTRA domain; Region: UTRA; pfam07702 909946001301 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 909946001302 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909946001303 catalytic residue [active] 909946001304 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 909946001305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946001306 motif II; other site 909946001307 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 909946001308 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 909946001309 conserved cys residue [active] 909946001310 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 909946001311 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 909946001312 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 909946001313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 909946001314 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 909946001315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946001316 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909946001317 putative substrate translocation pore; other site 909946001318 Sel1-like repeats; Region: SEL1; smart00671 909946001319 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 909946001320 Sel1 repeat; Region: Sel1; pfam08238 909946001321 Sel1-like repeats; Region: SEL1; smart00671 909946001322 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 909946001323 Sel1-like repeats; Region: SEL1; smart00671 909946001324 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 909946001325 Sel1-like repeats; Region: SEL1; smart00671 909946001326 Sel1-like repeats; Region: SEL1; smart00671 909946001327 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 909946001328 UbiA prenyltransferase family; Region: UbiA; pfam01040 909946001329 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 909946001330 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 909946001331 Subunit I/III interface [polypeptide binding]; other site 909946001332 Subunit III/IV interface [polypeptide binding]; other site 909946001333 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 909946001334 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 909946001335 D-pathway; other site 909946001336 Putative ubiquinol binding site [chemical binding]; other site 909946001337 Low-spin heme (heme b) binding site [chemical binding]; other site 909946001338 Putative water exit pathway; other site 909946001339 Binuclear center (heme o3/CuB) [ion binding]; other site 909946001340 K-pathway; other site 909946001341 Putative proton exit pathway; other site 909946001342 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 909946001343 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 909946001344 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 909946001345 muropeptide transporter; Reviewed; Region: ampG; PRK11902 909946001346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946001347 putative substrate translocation pore; other site 909946001348 hypothetical protein; Provisional; Region: PRK11627 909946001349 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 909946001350 transcriptional regulator BolA; Provisional; Region: PRK11628 909946001351 trigger factor; Provisional; Region: tig; PRK01490 909946001352 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 909946001353 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 909946001354 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 909946001355 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 909946001356 oligomer interface [polypeptide binding]; other site 909946001357 active site residues [active] 909946001358 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 909946001359 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 909946001360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946001361 Walker A motif; other site 909946001362 ATP binding site [chemical binding]; other site 909946001363 Walker B motif; other site 909946001364 Iron permease FTR1 family; Region: FTR1; cl00475 909946001365 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 909946001366 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 909946001367 Found in ATP-dependent protease La (LON); Region: LON; smart00464 909946001368 Found in ATP-dependent protease La (LON); Region: LON; smart00464 909946001369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946001370 Walker A motif; other site 909946001371 ATP binding site [chemical binding]; other site 909946001372 Walker B motif; other site 909946001373 arginine finger; other site 909946001374 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 909946001375 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 909946001376 IHF dimer interface [polypeptide binding]; other site 909946001377 IHF - DNA interface [nucleotide binding]; other site 909946001378 periplasmic folding chaperone; Provisional; Region: PRK10788 909946001379 SurA N-terminal domain; Region: SurA_N_3; cl07813 909946001380 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 909946001381 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 909946001382 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 909946001383 active site 909946001384 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 909946001385 Ligand Binding Site [chemical binding]; other site 909946001386 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 909946001387 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 909946001388 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 909946001389 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 909946001390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946001391 active site 909946001392 motif I; other site 909946001393 motif II; other site 909946001394 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 909946001395 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 909946001396 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909946001397 catalytic residue [active] 909946001398 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 909946001399 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909946001400 putative DNA binding site [nucleotide binding]; other site 909946001401 putative Zn2+ binding site [ion binding]; other site 909946001402 AsnC family; Region: AsnC_trans_reg; pfam01037 909946001403 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 909946001404 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909946001405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946001406 Walker A/P-loop; other site 909946001407 ATP binding site [chemical binding]; other site 909946001408 Q-loop/lid; other site 909946001409 ABC transporter signature motif; other site 909946001410 Walker B; other site 909946001411 D-loop; other site 909946001412 H-loop/switch region; other site 909946001413 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 909946001414 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909946001415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946001416 Walker A/P-loop; other site 909946001417 ATP binding site [chemical binding]; other site 909946001418 Q-loop/lid; other site 909946001419 ABC transporter signature motif; other site 909946001420 Walker B; other site 909946001421 D-loop; other site 909946001422 H-loop/switch region; other site 909946001423 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 909946001424 Nitrogen regulatory protein P-II; Region: P-II; smart00938 909946001425 ammonium transporter; Provisional; Region: PRK10666 909946001426 acyl-CoA thioesterase II; Provisional; Region: PRK10526 909946001427 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 909946001428 active site 909946001429 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 909946001430 catalytic triad [active] 909946001431 dimer interface [polypeptide binding]; other site 909946001432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 909946001433 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 909946001434 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 909946001435 DNA binding site [nucleotide binding] 909946001436 active site 909946001437 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 909946001438 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 909946001439 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946001440 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 909946001441 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 909946001442 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 909946001443 maltose O-acetyltransferase; Provisional; Region: PRK10092 909946001444 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 909946001445 active site 909946001446 substrate binding site [chemical binding]; other site 909946001447 trimer interface [polypeptide binding]; other site 909946001448 CoA binding site [chemical binding]; other site 909946001449 gene expression modulator; Provisional; Region: PRK10945 909946001450 Hha toxicity attenuator; Provisional; Region: PRK10667 909946001451 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 909946001452 Protein export membrane protein; Region: SecD_SecF; cl14618 909946001453 Protein export membrane protein; Region: SecD_SecF; cl14618 909946001454 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 909946001455 HlyD family secretion protein; Region: HlyD_3; pfam13437 909946001456 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 909946001457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946001458 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 909946001459 hypothetical protein; Provisional; Region: PRK11281 909946001460 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 909946001461 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 909946001462 Mechanosensitive ion channel; Region: MS_channel; pfam00924 909946001463 Uncharacterized conserved protein [Function unknown]; Region: COG5464 909946001464 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 909946001465 hypothetical protein; Provisional; Region: PRK11038 909946001466 primosomal replication protein N''; Provisional; Region: PRK10093 909946001467 hypothetical protein; Provisional; Region: PRK10527 909946001468 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909946001469 active site 909946001470 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 909946001471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946001472 Walker A motif; other site 909946001473 ATP binding site [chemical binding]; other site 909946001474 Walker B motif; other site 909946001475 DNA polymerase III subunit delta'; Validated; Region: PRK08485 909946001476 arginine finger; other site 909946001477 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 909946001478 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 909946001479 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 909946001480 hypothetical protein; Validated; Region: PRK00153 909946001481 recombination protein RecR; Reviewed; Region: recR; PRK00076 909946001482 RecR protein; Region: RecR; pfam02132 909946001483 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 909946001484 putative active site [active] 909946001485 putative metal-binding site [ion binding]; other site 909946001486 tetramer interface [polypeptide binding]; other site 909946001487 heat shock protein 90; Provisional; Region: PRK05218 909946001488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946001489 ATP binding site [chemical binding]; other site 909946001490 Mg2+ binding site [ion binding]; other site 909946001491 G-X-G motif; other site 909946001492 adenylate kinase; Reviewed; Region: adk; PRK00279 909946001493 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 909946001494 AMP-binding site [chemical binding]; other site 909946001495 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 909946001496 ferrochelatase; Reviewed; Region: hemH; PRK00035 909946001497 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 909946001498 C-terminal domain interface [polypeptide binding]; other site 909946001499 active site 909946001500 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 909946001501 active site 909946001502 N-terminal domain interface [polypeptide binding]; other site 909946001503 acetyl esterase; Provisional; Region: PRK10162 909946001504 inosine/guanosine kinase; Provisional; Region: PRK15074 909946001505 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909946001506 putative cation:proton antiport protein; Provisional; Region: PRK10669 909946001507 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 909946001508 TrkA-N domain; Region: TrkA_N; pfam02254 909946001509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946001510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909946001511 putative substrate translocation pore; other site 909946001512 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 909946001513 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 909946001514 active site 909946001515 metal binding site [ion binding]; metal-binding site 909946001516 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 909946001517 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 909946001518 putative deacylase active site [active] 909946001519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 909946001520 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 909946001521 copper exporting ATPase; Provisional; Region: copA; PRK10671 909946001522 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 909946001523 metal-binding site [ion binding] 909946001524 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 909946001525 metal-binding site [ion binding] 909946001526 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 909946001527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946001528 motif II; other site 909946001529 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 909946001530 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 909946001531 DNA binding residues [nucleotide binding] 909946001532 dimer interface [polypeptide binding]; other site 909946001533 copper binding site [ion binding]; other site 909946001534 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 909946001535 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 909946001536 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 909946001537 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 909946001538 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 909946001539 Walker A/P-loop; other site 909946001540 ATP binding site [chemical binding]; other site 909946001541 Q-loop/lid; other site 909946001542 ABC transporter signature motif; other site 909946001543 Walker B; other site 909946001544 D-loop; other site 909946001545 H-loop/switch region; other site 909946001546 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 909946001547 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 909946001548 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 909946001549 oxidoreductase; Provisional; Region: PRK08017 909946001550 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 909946001551 NADP binding site [chemical binding]; other site 909946001552 active site 909946001553 steroid binding site; other site 909946001554 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 909946001555 active site 909946001556 catalytic triad [active] 909946001557 oxyanion hole [active] 909946001558 switch loop; other site 909946001559 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 909946001560 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 909946001561 Walker A/P-loop; other site 909946001562 ATP binding site [chemical binding]; other site 909946001563 Q-loop/lid; other site 909946001564 ABC transporter signature motif; other site 909946001565 Walker B; other site 909946001566 D-loop; other site 909946001567 H-loop/switch region; other site 909946001568 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 909946001569 FtsX-like permease family; Region: FtsX; pfam02687 909946001570 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 909946001571 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 909946001572 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 909946001573 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 909946001574 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 909946001575 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 909946001576 Walker A/P-loop; other site 909946001577 ATP binding site [chemical binding]; other site 909946001578 Q-loop/lid; other site 909946001579 ABC transporter signature motif; other site 909946001580 Walker B; other site 909946001581 D-loop; other site 909946001582 H-loop/switch region; other site 909946001583 NIL domain; Region: NIL; pfam09383 909946001584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946001585 dimer interface [polypeptide binding]; other site 909946001586 conserved gate region; other site 909946001587 ABC-ATPase subunit interface; other site 909946001588 Predicted ATPase [General function prediction only]; Region: COG2603 909946001589 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 909946001590 active site residue [active] 909946001591 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 909946001592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946001593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 909946001594 dimerization interface [polypeptide binding]; other site 909946001595 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 909946001596 ureidoglycolate hydrolase; Provisional; Region: PRK03606 909946001597 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 909946001598 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 909946001599 Bacterial transcriptional regulator; Region: IclR; pfam01614 909946001600 glyoxylate carboligase; Provisional; Region: PRK11269 909946001601 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 909946001602 PYR/PP interface [polypeptide binding]; other site 909946001603 dimer interface [polypeptide binding]; other site 909946001604 TPP binding site [chemical binding]; other site 909946001605 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 909946001606 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 909946001607 TPP-binding site [chemical binding]; other site 909946001608 hydroxypyruvate isomerase; Provisional; Region: PRK09997 909946001609 tartronate semialdehyde reductase; Provisional; Region: PRK15059 909946001610 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 909946001611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946001612 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909946001613 putative substrate translocation pore; other site 909946001614 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 909946001615 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 909946001616 Na binding site [ion binding]; other site 909946001617 putative substrate binding site [chemical binding]; other site 909946001618 allantoinase; Provisional; Region: PRK08044 909946001619 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 909946001620 active site 909946001621 putative uracil/xanthine transporter; Provisional; Region: PRK11412 909946001622 glycerate kinase II; Provisional; Region: PRK09932 909946001623 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 909946001624 Mif2/CENP-C like; Region: Mif2; pfam11699 909946001625 Cupin domain; Region: Cupin_2; pfam07883 909946001626 allantoate amidohydrolase; Region: AllC; TIGR03176 909946001627 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 909946001628 active site 909946001629 metal binding site [ion binding]; metal-binding site 909946001630 dimer interface [polypeptide binding]; other site 909946001631 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 909946001632 membrane protein FdrA; Validated; Region: PRK06091 909946001633 CoA binding domain; Region: CoA_binding; pfam02629 909946001634 CoA-ligase; Region: Ligase_CoA; pfam00549 909946001635 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 909946001636 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 909946001637 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 909946001638 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 909946001639 putative substrate binding site [chemical binding]; other site 909946001640 nucleotide binding site [chemical binding]; other site 909946001641 nucleotide binding site [chemical binding]; other site 909946001642 homodimer interface [polypeptide binding]; other site 909946001643 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 909946001644 ATP-grasp domain; Region: ATP-grasp; pfam02222 909946001645 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 909946001646 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 909946001647 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 909946001648 putative active site [active] 909946001649 putative metal binding site [ion binding]; other site 909946001650 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 909946001651 substrate binding site [chemical binding]; other site 909946001652 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 909946001653 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 909946001654 active site 909946001655 HIGH motif; other site 909946001656 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 909946001657 KMSKS motif; other site 909946001658 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 909946001659 tRNA binding surface [nucleotide binding]; other site 909946001660 anticodon binding site; other site 909946001661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 909946001662 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 909946001663 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 909946001664 ribosome-associated protein; Provisional; Region: PRK11507 909946001665 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 909946001666 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 909946001667 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 909946001668 homodimer interface [polypeptide binding]; other site 909946001669 NADP binding site [chemical binding]; other site 909946001670 substrate binding site [chemical binding]; other site 909946001671 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 909946001672 fimbrial protein FimI; Provisional; Region: PRK15200 909946001673 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 909946001674 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946001675 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946001676 outer membrane usher protein FimD; Provisional; Region: PRK15198 909946001677 PapC N-terminal domain; Region: PapC_N; pfam13954 909946001678 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 909946001679 PapC C-terminal domain; Region: PapC_C; pfam13953 909946001680 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 909946001681 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 909946001682 transcriptional regulator FimZ; Provisional; Region: PRK09935 909946001683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946001684 active site 909946001685 phosphorylation site [posttranslational modification] 909946001686 intermolecular recognition site; other site 909946001687 dimerization interface [polypeptide binding]; other site 909946001688 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946001689 DNA binding residues [nucleotide binding] 909946001690 dimerization interface [polypeptide binding]; other site 909946001691 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 909946001692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946001693 DNA binding residues [nucleotide binding] 909946001694 dimerization interface [polypeptide binding]; other site 909946001695 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 909946001696 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 909946001697 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 909946001698 Ligand binding site; other site 909946001699 Putative Catalytic site; other site 909946001700 DXD motif; other site 909946001701 Predicted membrane protein [Function unknown]; Region: COG2246 909946001702 GtrA-like protein; Region: GtrA; pfam04138 909946001703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946001704 ATP binding site [chemical binding]; other site 909946001705 Mg2+ binding site [ion binding]; other site 909946001706 G-X-G motif; other site 909946001707 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 909946001708 Cupin; Region: Cupin_6; pfam12852 909946001709 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 909946001710 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946001711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946001712 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 909946001713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909946001714 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 909946001715 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 909946001716 Predicted membrane protein [Function unknown]; Region: COG3059 909946001717 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 909946001718 phenylalanine transporter; Provisional; Region: PRK10249 909946001719 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 909946001720 Mechanosensitive ion channel; Region: MS_channel; pfam00924 909946001721 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 909946001722 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 909946001723 active site 909946001724 oxyanion hole [active] 909946001725 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 909946001726 catalytic triad [active] 909946001727 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 909946001728 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 909946001729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946001730 ATP binding site [chemical binding]; other site 909946001731 Walker B motif; other site 909946001732 arginine finger; other site 909946001733 Transcriptional antiterminator [Transcription]; Region: COG3933 909946001734 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 909946001735 active pocket/dimerization site; other site 909946001736 active site 909946001737 phosphorylation site [posttranslational modification] 909946001738 PRD domain; Region: PRD; pfam00874 909946001739 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 909946001740 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 909946001741 putative active site [active] 909946001742 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 909946001743 dimer interface [polypeptide binding]; other site 909946001744 active site 909946001745 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 909946001746 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 909946001747 dimer interface [polypeptide binding]; other site 909946001748 active site 909946001749 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 909946001750 dimer interface [polypeptide binding]; other site 909946001751 active site 909946001752 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 909946001753 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 909946001754 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 909946001755 active site 909946001756 phosphorylation site [posttranslational modification] 909946001757 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 909946001758 active pocket/dimerization site; other site 909946001759 active site 909946001760 phosphorylation site [posttranslational modification] 909946001761 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 909946001762 dimer interface [polypeptide binding]; other site 909946001763 FMN binding site [chemical binding]; other site 909946001764 hypothetical protein; Provisional; Region: PRK10250 909946001765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909946001766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946001767 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 909946001768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946001769 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 909946001770 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 909946001771 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 909946001772 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 909946001773 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 909946001774 outer membrane receptor FepA; Provisional; Region: PRK13524 909946001775 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 909946001776 N-terminal plug; other site 909946001777 ligand-binding site [chemical binding]; other site 909946001778 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 909946001779 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 909946001780 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 909946001781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 909946001782 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 909946001783 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 909946001784 acyl-activating enzyme (AAE) consensus motif; other site 909946001785 AMP binding site [chemical binding]; other site 909946001786 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 909946001787 LPS O-antigen length regulator; Provisional; Region: PRK10381 909946001788 Chain length determinant protein; Region: Wzz; pfam02706 909946001789 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 909946001790 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 909946001791 Walker A/P-loop; other site 909946001792 ATP binding site [chemical binding]; other site 909946001793 Q-loop/lid; other site 909946001794 ABC transporter signature motif; other site 909946001795 Walker B; other site 909946001796 D-loop; other site 909946001797 H-loop/switch region; other site 909946001798 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 909946001799 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909946001800 ABC-ATPase subunit interface; other site 909946001801 dimer interface [polypeptide binding]; other site 909946001802 putative PBP binding regions; other site 909946001803 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 909946001804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909946001805 ABC-ATPase subunit interface; other site 909946001806 dimer interface [polypeptide binding]; other site 909946001807 putative PBP binding regions; other site 909946001808 enterobactin exporter EntS; Provisional; Region: PRK10489 909946001809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946001810 putative substrate translocation pore; other site 909946001811 ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592 909946001812 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 909946001813 siderophore binding site; other site 909946001814 isochorismate synthase EntC; Provisional; Region: PRK15016 909946001815 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 909946001816 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 909946001817 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 909946001818 acyl-activating enzyme (AAE) consensus motif; other site 909946001819 active site 909946001820 AMP binding site [chemical binding]; other site 909946001821 substrate binding site [chemical binding]; other site 909946001822 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 909946001823 hydrophobic substrate binding pocket; other site 909946001824 Isochorismatase family; Region: Isochorismatase; pfam00857 909946001825 active site 909946001826 conserved cis-peptide bond; other site 909946001827 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 909946001828 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 909946001829 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 909946001830 putative NAD(P) binding site [chemical binding]; other site 909946001831 active site 909946001832 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 909946001833 CoenzymeA binding site [chemical binding]; other site 909946001834 subunit interaction site [polypeptide binding]; other site 909946001835 PHB binding site; other site 909946001836 carbon starvation protein A; Provisional; Region: PRK15015 909946001837 Carbon starvation protein CstA; Region: CstA; pfam02554 909946001838 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 909946001839 Uncharacterized small protein [Function unknown]; Region: COG2879 909946001840 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 909946001841 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 909946001842 putative active site [active] 909946001843 metal binding site [ion binding]; metal-binding site 909946001844 methionine aminotransferase; Validated; Region: PRK09082 909946001845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909946001846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946001847 homodimer interface [polypeptide binding]; other site 909946001848 catalytic residue [active] 909946001849 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 909946001850 ParB-like nuclease domain; Region: ParBc; pfam02195 909946001851 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 909946001852 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 909946001853 Active Sites [active] 909946001854 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 909946001855 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 909946001856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946001857 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 909946001858 dimerization interface [polypeptide binding]; other site 909946001859 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 909946001860 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 909946001861 dimerization domain [polypeptide binding]; other site 909946001862 dimer interface [polypeptide binding]; other site 909946001863 catalytic residues [active] 909946001864 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 909946001865 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 909946001866 dimer interface [polypeptide binding]; other site 909946001867 decamer (pentamer of dimers) interface [polypeptide binding]; other site 909946001868 catalytic triad [active] 909946001869 peroxidatic and resolving cysteines [active] 909946001870 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 909946001871 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 909946001872 catalytic residue [active] 909946001873 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 909946001874 catalytic residues [active] 909946001875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909946001876 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909946001877 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 909946001878 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 909946001879 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 909946001880 putative [4Fe-4S] binding site [ion binding]; other site 909946001881 putative molybdopterin cofactor binding site [chemical binding]; other site 909946001882 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 909946001883 molybdopterin cofactor binding site; other site 909946001884 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 909946001885 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 909946001886 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 909946001887 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 909946001888 Ligand Binding Site [chemical binding]; other site 909946001889 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 909946001890 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 909946001891 NAD binding site [chemical binding]; other site 909946001892 catalytic Zn binding site [ion binding]; other site 909946001893 structural Zn binding site [ion binding]; other site 909946001894 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 909946001895 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 909946001896 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 909946001897 B1 nucleotide binding pocket [chemical binding]; other site 909946001898 B2 nucleotide binding pocket [chemical binding]; other site 909946001899 CAS motifs; other site 909946001900 active site 909946001901 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 909946001902 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 909946001903 transmembrane helices; other site 909946001904 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 909946001905 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 909946001906 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 909946001907 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 909946001908 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 909946001909 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 909946001910 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 909946001911 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 909946001912 putative active site [active] 909946001913 (T/H)XGH motif; other site 909946001914 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 909946001915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 909946001916 putative active site [active] 909946001917 heme pocket [chemical binding]; other site 909946001918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946001919 ATP binding site [chemical binding]; other site 909946001920 Mg2+ binding site [ion binding]; other site 909946001921 G-X-G motif; other site 909946001922 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 909946001923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946001924 active site 909946001925 phosphorylation site [posttranslational modification] 909946001926 intermolecular recognition site; other site 909946001927 dimerization interface [polypeptide binding]; other site 909946001928 Transcriptional regulator; Region: CitT; pfam12431 909946001929 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 909946001930 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 909946001931 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 909946001932 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 909946001933 DNA-binding site [nucleotide binding]; DNA binding site 909946001934 RNA-binding motif; other site 909946001935 chromosome condensation membrane protein; Provisional; Region: PRK14196 909946001936 Predicted amidohydrolase [General function prediction only]; Region: COG0388 909946001937 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 909946001938 putative active site [active] 909946001939 catalytic triad [active] 909946001940 putative dimer interface [polypeptide binding]; other site 909946001941 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 909946001942 lipoyl synthase; Provisional; Region: PRK05481 909946001943 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946001944 FeS/SAM binding site; other site 909946001945 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 909946001946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946001947 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 909946001948 substrate binding pocket [chemical binding]; other site 909946001949 dimerization interface [polypeptide binding]; other site 909946001950 lipoate-protein ligase B; Provisional; Region: PRK14342 909946001951 hypothetical protein; Provisional; Region: PRK04998 909946001952 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 909946001953 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 909946001954 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 909946001955 rare lipoprotein A; Provisional; Region: PRK10672 909946001956 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 909946001957 Sporulation related domain; Region: SPOR; pfam05036 909946001958 cell wall shape-determining protein; Provisional; Region: PRK10794 909946001959 penicillin-binding protein 2; Provisional; Region: PRK10795 909946001960 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 909946001961 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 909946001962 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 909946001963 ribosome-associated protein; Provisional; Region: PRK11538 909946001964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 909946001965 catalytic core [active] 909946001966 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 909946001967 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909946001968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946001969 homodimer interface [polypeptide binding]; other site 909946001970 catalytic residue [active] 909946001971 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 909946001972 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 909946001973 active site 909946001974 (T/H)XGH motif; other site 909946001975 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 909946001976 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 909946001977 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 909946001978 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 909946001979 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 909946001980 HIGH motif; other site 909946001981 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 909946001982 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 909946001983 active site 909946001984 KMSKS motif; other site 909946001985 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 909946001986 tRNA binding surface [nucleotide binding]; other site 909946001987 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 909946001988 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 909946001989 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 909946001990 Propionate catabolism activator; Region: PrpR_N; pfam06506 909946001991 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 909946001992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946001993 Walker A motif; other site 909946001994 ATP binding site [chemical binding]; other site 909946001995 Walker B motif; other site 909946001996 arginine finger; other site 909946001997 hypothetical protein; Provisional; Region: PRK11032 909946001998 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 909946001999 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 909946002000 Sel1-like repeats; Region: SEL1; smart00671 909946002001 Sel1-like repeats; Region: SEL1; smart00671 909946002002 Sel1-like repeats; Region: SEL1; smart00671 909946002003 Sel1-like repeats; Region: SEL1; smart00671 909946002004 Sel1-like repeats; Region: SEL1; smart00671 909946002005 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 909946002006 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 909946002007 HSP70 interaction site [polypeptide binding]; other site 909946002008 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 909946002009 DnaJ domain; Region: DnaJ; pfam00226 909946002010 HSP70 interaction site [polypeptide binding]; other site 909946002011 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 909946002012 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 909946002013 nucleotide binding site [chemical binding]; other site 909946002014 putative NEF/HSP70 interaction site [polypeptide binding]; other site 909946002015 SBD interface [polypeptide binding]; other site 909946002016 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 909946002017 active site 909946002018 tetramer interface [polypeptide binding]; other site 909946002019 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 909946002020 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 909946002021 Walker A/P-loop; other site 909946002022 ATP binding site [chemical binding]; other site 909946002023 Q-loop/lid; other site 909946002024 ABC transporter signature motif; other site 909946002025 Walker B; other site 909946002026 D-loop; other site 909946002027 H-loop/switch region; other site 909946002028 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 909946002029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946002030 dimer interface [polypeptide binding]; other site 909946002031 conserved gate region; other site 909946002032 putative PBP binding loops; other site 909946002033 ABC-ATPase subunit interface; other site 909946002034 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 909946002035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946002036 dimer interface [polypeptide binding]; other site 909946002037 conserved gate region; other site 909946002038 putative PBP binding loops; other site 909946002039 ABC-ATPase subunit interface; other site 909946002040 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 909946002041 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946002042 substrate binding pocket [chemical binding]; other site 909946002043 membrane-bound complex binding site; other site 909946002044 hinge residues; other site 909946002045 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 909946002046 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 909946002047 putative active site [active] 909946002048 catalytic triad [active] 909946002049 putative dimer interface [polypeptide binding]; other site 909946002050 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 909946002051 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 909946002052 Transporter associated domain; Region: CorC_HlyC; smart01091 909946002053 metal-binding heat shock protein; Provisional; Region: PRK00016 909946002054 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 909946002055 PhoH-like protein; Region: PhoH; pfam02562 909946002056 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 909946002057 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 909946002058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946002059 FeS/SAM binding site; other site 909946002060 TRAM domain; Region: TRAM; pfam01938 909946002061 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 909946002062 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 909946002063 asparagine synthetase B; Provisional; Region: asnB; PRK09431 909946002064 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 909946002065 active site 909946002066 dimer interface [polypeptide binding]; other site 909946002067 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 909946002068 Ligand Binding Site [chemical binding]; other site 909946002069 Molecular Tunnel; other site 909946002070 UMP phosphatase; Provisional; Region: PRK10444 909946002071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946002072 active site 909946002073 motif I; other site 909946002074 motif II; other site 909946002075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946002076 MarR family; Region: MarR; pfam01047 909946002077 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 909946002078 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 909946002079 nucleotide binding site [chemical binding]; other site 909946002080 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 909946002081 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 909946002082 active site 909946002083 dimer interface [polypeptide binding]; other site 909946002084 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 909946002085 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 909946002086 active site 909946002087 trimer interface [polypeptide binding]; other site 909946002088 allosteric site; other site 909946002089 active site lid [active] 909946002090 hexamer (dimer of trimers) interface [polypeptide binding]; other site 909946002091 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 909946002092 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 909946002093 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 909946002094 active site turn [active] 909946002095 phosphorylation site [posttranslational modification] 909946002096 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 909946002097 HPr interaction site; other site 909946002098 glycerol kinase (GK) interaction site [polypeptide binding]; other site 909946002099 active site 909946002100 phosphorylation site [posttranslational modification] 909946002101 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 909946002102 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 909946002103 active site 909946002104 HIGH motif; other site 909946002105 nucleotide binding site [chemical binding]; other site 909946002106 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 909946002107 KMSKS motif; other site 909946002108 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 909946002109 outer membrane porin, OprD family; Region: OprD; pfam03573 909946002110 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 909946002111 YbfN-like lipoprotein; Region: YbfN; pfam13982 909946002112 citrate-proton symporter; Provisional; Region: PRK15075 909946002113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946002114 putative substrate translocation pore; other site 909946002115 tricarballylate utilization protein B; Provisional; Region: PRK15033 909946002116 tricarballylate dehydrogenase; Validated; Region: PRK08274 909946002117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909946002118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946002119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946002120 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 909946002121 putative dimerization interface [polypeptide binding]; other site 909946002122 ferric uptake regulator; Provisional; Region: fur; PRK09462 909946002123 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 909946002124 metal binding site 2 [ion binding]; metal-binding site 909946002125 putative DNA binding helix; other site 909946002126 metal binding site 1 [ion binding]; metal-binding site 909946002127 dimer interface [polypeptide binding]; other site 909946002128 structural Zn2+ binding site [ion binding]; other site 909946002129 flavodoxin FldA; Validated; Region: PRK09267 909946002130 LexA regulated protein; Provisional; Region: PRK11675 909946002131 acyl-CoA esterase; Provisional; Region: PRK10673 909946002132 PGAP1-like protein; Region: PGAP1; pfam07819 909946002133 replication initiation regulator SeqA; Provisional; Region: PRK11187 909946002134 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 909946002135 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 909946002136 active site 909946002137 substrate binding site [chemical binding]; other site 909946002138 metal binding site [ion binding]; metal-binding site 909946002139 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 909946002140 putrescine transporter; Provisional; Region: potE; PRK10655 909946002141 ornithine decarboxylase; Provisional; Region: PRK13578 909946002142 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 909946002143 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 909946002144 homodimer interface [polypeptide binding]; other site 909946002145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946002146 catalytic residue [active] 909946002147 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 909946002148 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 909946002149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946002150 active site 909946002151 phosphorylation site [posttranslational modification] 909946002152 intermolecular recognition site; other site 909946002153 dimerization interface [polypeptide binding]; other site 909946002154 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946002155 DNA binding site [nucleotide binding] 909946002156 sensor protein KdpD; Provisional; Region: PRK10490 909946002157 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 909946002158 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 909946002159 Ligand Binding Site [chemical binding]; other site 909946002160 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 909946002161 GAF domain; Region: GAF_3; pfam13492 909946002162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946002163 dimer interface [polypeptide binding]; other site 909946002164 phosphorylation site [posttranslational modification] 909946002165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946002166 ATP binding site [chemical binding]; other site 909946002167 Mg2+ binding site [ion binding]; other site 909946002168 G-X-G motif; other site 909946002169 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 909946002170 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 909946002171 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 909946002172 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 909946002173 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 909946002174 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 909946002175 DNA photolyase; Region: DNA_photolyase; pfam00875 909946002176 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 909946002177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946002178 putative substrate translocation pore; other site 909946002179 POT family; Region: PTR2; pfam00854 909946002180 Uncharacterized conserved protein [Function unknown]; Region: COG0327 909946002181 metal-binding protein; Provisional; Region: PRK10799 909946002182 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 909946002183 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 909946002184 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 909946002185 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 909946002186 putative active site [active] 909946002187 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 909946002188 active site 909946002189 DNA binding site [nucleotide binding] 909946002190 Int/Topo IB signature motif; other site 909946002191 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 909946002192 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 909946002193 active site 909946002194 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 909946002195 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 909946002196 putative ADP-binding pocket [chemical binding]; other site 909946002197 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 909946002198 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 909946002199 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 909946002200 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 909946002201 Walker A/P-loop; other site 909946002202 ATP binding site [chemical binding]; other site 909946002203 Q-loop/lid; other site 909946002204 ABC transporter signature motif; other site 909946002205 Walker B; other site 909946002206 D-loop; other site 909946002207 H-loop/switch region; other site 909946002208 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 909946002209 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 909946002210 active site 909946002211 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 909946002212 active site 909946002213 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 909946002214 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 909946002215 endonuclease VIII; Provisional; Region: PRK10445 909946002216 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 909946002217 DNA binding site [nucleotide binding] 909946002218 catalytic residue [active] 909946002219 putative catalytic residues [active] 909946002220 H2TH interface [polypeptide binding]; other site 909946002221 intercalation triad [nucleotide binding]; other site 909946002222 substrate specificity determining residue; other site 909946002223 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 909946002224 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 909946002225 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 909946002226 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 909946002227 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 909946002228 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 909946002229 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 909946002230 dimer interface [polypeptide binding]; other site 909946002231 active site 909946002232 citrylCoA binding site [chemical binding]; other site 909946002233 NADH binding [chemical binding]; other site 909946002234 cationic pore residues; other site 909946002235 oxalacetate/citrate binding site [chemical binding]; other site 909946002236 coenzyme A binding site [chemical binding]; other site 909946002237 catalytic triad [active] 909946002238 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 909946002239 Iron-sulfur protein interface; other site 909946002240 proximal quinone binding site [chemical binding]; other site 909946002241 SdhD (CybS) interface [polypeptide binding]; other site 909946002242 proximal heme binding site [chemical binding]; other site 909946002243 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 909946002244 SdhC subunit interface [polypeptide binding]; other site 909946002245 proximal heme binding site [chemical binding]; other site 909946002246 cardiolipin binding site; other site 909946002247 Iron-sulfur protein interface; other site 909946002248 proximal quinone binding site [chemical binding]; other site 909946002249 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 909946002250 L-aspartate oxidase; Provisional; Region: PRK06175 909946002251 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 909946002252 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 909946002253 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 909946002254 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 909946002255 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 909946002256 TPP-binding site [chemical binding]; other site 909946002257 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 909946002258 dimer interface [polypeptide binding]; other site 909946002259 PYR/PP interface [polypeptide binding]; other site 909946002260 TPP binding site [chemical binding]; other site 909946002261 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 909946002262 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 909946002263 E3 interaction surface; other site 909946002264 lipoyl attachment site [posttranslational modification]; other site 909946002265 e3 binding domain; Region: E3_binding; pfam02817 909946002266 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 909946002267 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 909946002268 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 909946002269 CoA-ligase; Region: Ligase_CoA; pfam00549 909946002270 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 909946002271 CoA binding domain; Region: CoA_binding; smart00881 909946002272 CoA-ligase; Region: Ligase_CoA; pfam00549 909946002273 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 909946002274 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 909946002275 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 909946002276 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 909946002277 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 909946002278 hypothetical protein; Provisional; Region: PRK10588 909946002279 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 909946002280 active site 909946002281 colicin uptake protein TolQ; Provisional; Region: PRK10801 909946002282 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 909946002283 colicin uptake protein TolR; Provisional; Region: PRK11024 909946002284 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 909946002285 TolA C-terminal; Region: TolA; pfam06519 909946002286 translocation protein TolB; Provisional; Region: tolB; PRK03629 909946002287 TolB amino-terminal domain; Region: TolB_N; pfam04052 909946002288 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 909946002289 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 909946002290 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 909946002291 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 909946002292 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 909946002293 ligand binding site [chemical binding]; other site 909946002294 tol-pal system protein YbgF; Provisional; Region: PRK10803 909946002295 Tetratricopeptide repeat; Region: TPR_6; pfam13174 909946002296 Tetratricopeptide repeat; Region: TPR_6; pfam13174 909946002297 quinolinate synthetase; Provisional; Region: PRK09375 909946002298 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 909946002299 zinc transporter ZitB; Provisional; Region: PRK03557 909946002300 YbgS-like protein; Region: YbgS; pfam13985 909946002301 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 909946002302 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 909946002303 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 909946002304 fumarate hydratase; Provisional; Region: PRK06246 909946002305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946002306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946002307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 909946002308 dimerization interface [polypeptide binding]; other site 909946002309 cell density-dependent motility repressor; Provisional; Region: PRK10082 909946002310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946002311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 909946002312 dimerization interface [polypeptide binding]; other site 909946002313 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 909946002314 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 909946002315 transmembrane helices; other site 909946002316 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 909946002317 oxaloacetate decarboxylase; Provisional; Region: PRK14040 909946002318 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 909946002319 active site 909946002320 catalytic residues [active] 909946002321 metal binding site [ion binding]; metal-binding site 909946002322 homodimer binding site [polypeptide binding]; other site 909946002323 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 909946002324 carboxyltransferase (CT) interaction site; other site 909946002325 biotinylation site [posttranslational modification]; other site 909946002326 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 909946002327 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 909946002328 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 909946002329 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909946002330 dimer interface [polypeptide binding]; other site 909946002331 putative PBP binding regions; other site 909946002332 ABC-ATPase subunit interface; other site 909946002333 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 909946002334 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 909946002335 Walker A/P-loop; other site 909946002336 ATP binding site [chemical binding]; other site 909946002337 Q-loop/lid; other site 909946002338 ABC transporter signature motif; other site 909946002339 Walker B; other site 909946002340 D-loop; other site 909946002341 H-loop/switch region; other site 909946002342 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 909946002343 catalytic core [active] 909946002344 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 909946002345 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 909946002346 active site 909946002347 catalytic residues [active] 909946002348 galactokinase; Provisional; Region: PRK05101 909946002349 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 909946002350 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 909946002351 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 909946002352 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 909946002353 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 909946002354 dimer interface [polypeptide binding]; other site 909946002355 active site 909946002356 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 909946002357 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 909946002358 NAD binding site [chemical binding]; other site 909946002359 homodimer interface [polypeptide binding]; other site 909946002360 active site 909946002361 substrate binding site [chemical binding]; other site 909946002362 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 909946002363 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 909946002364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946002365 Walker A/P-loop; other site 909946002366 ATP binding site [chemical binding]; other site 909946002367 Q-loop/lid; other site 909946002368 ABC transporter signature motif; other site 909946002369 Walker B; other site 909946002370 D-loop; other site 909946002371 H-loop/switch region; other site 909946002372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946002373 Walker A/P-loop; other site 909946002374 ATP binding site [chemical binding]; other site 909946002375 Q-loop/lid; other site 909946002376 ABC transporter signature motif; other site 909946002377 Walker B; other site 909946002378 D-loop; other site 909946002379 H-loop/switch region; other site 909946002380 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 909946002381 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 909946002382 molybdenum-pterin binding domain; Region: Mop; TIGR00638 909946002383 TOBE domain; Region: TOBE; pfam03459 909946002384 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 909946002385 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 909946002386 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946002387 substrate binding pocket [chemical binding]; other site 909946002388 membrane-bound complex binding site; other site 909946002389 hinge residues; other site 909946002390 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 909946002391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946002392 dimer interface [polypeptide binding]; other site 909946002393 conserved gate region; other site 909946002394 putative PBP binding loops; other site 909946002395 ABC-ATPase subunit interface; other site 909946002396 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 909946002397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946002398 Walker A/P-loop; other site 909946002399 ATP binding site [chemical binding]; other site 909946002400 Q-loop/lid; other site 909946002401 ABC transporter signature motif; other site 909946002402 Walker B; other site 909946002403 D-loop; other site 909946002404 H-loop/switch region; other site 909946002405 molybdenum-pterin binding domain; Region: Mop; TIGR00638 909946002406 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 909946002407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946002408 active site 909946002409 motif I; other site 909946002410 motif II; other site 909946002411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946002412 6-phosphogluconolactonase; Provisional; Region: PRK11028 909946002413 acyl-CoA thioesterase; Provisional; Region: PRK10531 909946002414 putative pectinesterase; Region: PLN02432; cl01911 909946002415 imidazolonepropionase; Validated; Region: PRK09356 909946002416 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 909946002417 active site 909946002418 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 909946002419 putative active site [active] 909946002420 putative metal binding site [ion binding]; other site 909946002421 histidine utilization repressor; Provisional; Region: PRK14999 909946002422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946002423 DNA-binding site [nucleotide binding]; DNA binding site 909946002424 UTRA domain; Region: UTRA; pfam07702 909946002425 urocanate hydratase; Provisional; Region: PRK05414 909946002426 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 909946002427 active sites [active] 909946002428 tetramer interface [polypeptide binding]; other site 909946002429 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 909946002430 substrate binding site [chemical binding]; other site 909946002431 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 909946002432 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 909946002433 inhibitor-cofactor binding pocket; inhibition site 909946002434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946002435 catalytic residue [active] 909946002436 biotin synthase; Provisional; Region: PRK15108 909946002437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946002438 FeS/SAM binding site; other site 909946002439 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 909946002440 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 909946002441 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 909946002442 substrate-cofactor binding pocket; other site 909946002443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946002444 catalytic residue [active] 909946002445 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 909946002446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946002447 S-adenosylmethionine binding site [chemical binding]; other site 909946002448 AAA domain; Region: AAA_26; pfam13500 909946002449 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 909946002450 excinuclease ABC subunit B; Provisional; Region: PRK05298 909946002451 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909946002452 ATP binding site [chemical binding]; other site 909946002453 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946002454 nucleotide binding region [chemical binding]; other site 909946002455 ATP-binding site [chemical binding]; other site 909946002456 Ultra-violet resistance protein B; Region: UvrB; pfam12344 909946002457 UvrB/uvrC motif; Region: UVR; pfam02151 909946002458 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 909946002459 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 909946002460 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 909946002461 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 909946002462 Leucine-rich repeats; other site 909946002463 Substrate binding site [chemical binding]; other site 909946002464 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 909946002465 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 909946002466 putative substrate binding pocket [chemical binding]; other site 909946002467 dimer interface [polypeptide binding]; other site 909946002468 phosphate binding site [ion binding]; other site 909946002469 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 909946002470 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946002471 FeS/SAM binding site; other site 909946002472 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 909946002473 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 909946002474 MPT binding site; other site 909946002475 trimer interface [polypeptide binding]; other site 909946002476 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 909946002477 trimer interface [polypeptide binding]; other site 909946002478 dimer interface [polypeptide binding]; other site 909946002479 putative active site [active] 909946002480 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 909946002481 MoaE interaction surface [polypeptide binding]; other site 909946002482 MoeB interaction surface [polypeptide binding]; other site 909946002483 thiocarboxylated glycine; other site 909946002484 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 909946002485 MoaE homodimer interface [polypeptide binding]; other site 909946002486 MoaD interaction [polypeptide binding]; other site 909946002487 active site residues [active] 909946002488 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 909946002489 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 909946002490 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 909946002491 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 909946002492 Predicted integral membrane protein [Function unknown]; Region: COG0392 909946002493 cardiolipin synthase 2; Provisional; Region: PRK11263 909946002494 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 909946002495 putative active site [active] 909946002496 catalytic site [active] 909946002497 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 909946002498 putative active site [active] 909946002499 catalytic site [active] 909946002500 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 909946002501 putative catalytic site [active] 909946002502 putative metal binding site [ion binding]; other site 909946002503 putative phosphate binding site [ion binding]; other site 909946002504 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 909946002505 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 909946002506 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 909946002507 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 909946002508 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 909946002509 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 909946002510 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 909946002511 Walker A/P-loop; other site 909946002512 ATP binding site [chemical binding]; other site 909946002513 Q-loop/lid; other site 909946002514 ABC transporter signature motif; other site 909946002515 Walker B; other site 909946002516 D-loop; other site 909946002517 H-loop/switch region; other site 909946002518 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 909946002519 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 909946002520 Walker A/P-loop; other site 909946002521 ATP binding site [chemical binding]; other site 909946002522 Q-loop/lid; other site 909946002523 ABC transporter signature motif; other site 909946002524 Walker B; other site 909946002525 D-loop; other site 909946002526 H-loop/switch region; other site 909946002527 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 909946002528 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 909946002529 HlyD family secretion protein; Region: HlyD_3; pfam13437 909946002530 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 909946002531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946002532 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 909946002533 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 909946002534 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 909946002535 ATP binding site [chemical binding]; other site 909946002536 Mg++ binding site [ion binding]; other site 909946002537 motif III; other site 909946002538 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946002539 nucleotide binding region [chemical binding]; other site 909946002540 ATP-binding site [chemical binding]; other site 909946002541 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 909946002542 DEAD_2; Region: DEAD_2; pfam06733 909946002543 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 909946002544 glycosyl transferase family protein; Provisional; Region: PRK08136 909946002545 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 909946002546 hypothetical protein; Provisional; Region: PRK10259 909946002547 hypothetical protein; Provisional; Region: PRK11019 909946002548 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 909946002549 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 909946002550 putative mechanosensitive channel protein; Provisional; Region: PRK11465 909946002551 Mechanosensitive ion channel; Region: MS_channel; pfam00924 909946002552 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 909946002553 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 909946002554 Walker A/P-loop; other site 909946002555 ATP binding site [chemical binding]; other site 909946002556 Q-loop/lid; other site 909946002557 ABC transporter signature motif; other site 909946002558 Walker B; other site 909946002559 D-loop; other site 909946002560 H-loop/switch region; other site 909946002561 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 909946002562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946002563 dimer interface [polypeptide binding]; other site 909946002564 conserved gate region; other site 909946002565 putative PBP binding loops; other site 909946002566 ABC-ATPase subunit interface; other site 909946002567 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 909946002568 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946002569 substrate binding pocket [chemical binding]; other site 909946002570 membrane-bound complex binding site; other site 909946002571 hinge residues; other site 909946002572 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 909946002573 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 909946002574 dimerization interface [polypeptide binding]; other site 909946002575 DPS ferroxidase diiron center [ion binding]; other site 909946002576 ion pore; other site 909946002577 threonine and homoserine efflux system; Provisional; Region: PRK10532 909946002578 EamA-like transporter family; Region: EamA; pfam00892 909946002579 outer membrane protein X; Provisional; Region: ompX; PRK09408 909946002580 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 909946002581 Sulfatase; Region: Sulfatase; pfam00884 909946002582 manganese transport regulator MntR; Provisional; Region: PRK11050 909946002583 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 909946002584 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 909946002585 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 909946002586 transmembrane helices; other site 909946002587 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 909946002588 L,D-transpeptidase; Provisional; Region: PRK10260 909946002589 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 909946002590 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 909946002591 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909946002592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946002593 Walker A/P-loop; other site 909946002594 ATP binding site [chemical binding]; other site 909946002595 ABC transporter signature motif; other site 909946002596 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909946002597 Walker B; other site 909946002598 ABC transporter; Region: ABC_tran_2; pfam12848 909946002599 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909946002600 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 909946002601 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 909946002602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 909946002603 motif II; other site 909946002604 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946002605 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 909946002606 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 909946002607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946002608 active site 909946002609 motif I; other site 909946002610 motif II; other site 909946002611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946002612 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 909946002613 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 909946002614 dimer interface [polypeptide binding]; other site 909946002615 active site 909946002616 glycine loop; other site 909946002617 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 909946002618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946002619 FeS/SAM binding site; other site 909946002620 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 909946002621 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 909946002622 ATP binding site [chemical binding]; other site 909946002623 substrate interface [chemical binding]; other site 909946002624 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 909946002625 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 909946002626 dimer interface [polypeptide binding]; other site 909946002627 putative functional site; other site 909946002628 putative MPT binding site; other site 909946002629 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 909946002630 catalytic nucleophile [active] 909946002631 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 909946002632 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909946002633 Walker A/P-loop; other site 909946002634 ATP binding site [chemical binding]; other site 909946002635 Q-loop/lid; other site 909946002636 ABC transporter signature motif; other site 909946002637 Walker B; other site 909946002638 D-loop; other site 909946002639 H-loop/switch region; other site 909946002640 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 909946002641 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909946002642 Walker A/P-loop; other site 909946002643 ATP binding site [chemical binding]; other site 909946002644 Q-loop/lid; other site 909946002645 ABC transporter signature motif; other site 909946002646 Walker B; other site 909946002647 D-loop; other site 909946002648 H-loop/switch region; other site 909946002649 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 909946002650 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 909946002651 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 909946002652 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 909946002653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946002654 dimer interface [polypeptide binding]; other site 909946002655 conserved gate region; other site 909946002656 putative PBP binding loops; other site 909946002657 ABC-ATPase subunit interface; other site 909946002658 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 909946002659 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 909946002660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946002661 dimer interface [polypeptide binding]; other site 909946002662 conserved gate region; other site 909946002663 putative PBP binding loops; other site 909946002664 ABC-ATPase subunit interface; other site 909946002665 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 909946002666 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 909946002667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946002668 FeS/SAM binding site; other site 909946002669 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 909946002670 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 909946002671 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 909946002672 Ligand binding site [chemical binding]; other site 909946002673 Electron transfer flavoprotein domain; Region: ETF; pfam01012 909946002674 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 909946002675 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 909946002676 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 909946002677 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 909946002678 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 909946002679 active site 909946002680 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 909946002681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909946002682 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 909946002683 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 909946002684 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946002685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946002686 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 909946002687 putative dimerization interface [polypeptide binding]; other site 909946002688 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 909946002689 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 909946002690 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 909946002691 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 909946002692 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 909946002693 putative C-terminal domain interface [polypeptide binding]; other site 909946002694 putative GSH binding site (G-site) [chemical binding]; other site 909946002695 putative dimer interface [polypeptide binding]; other site 909946002696 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 909946002697 putative N-terminal domain interface [polypeptide binding]; other site 909946002698 putative dimer interface [polypeptide binding]; other site 909946002699 putative substrate binding pocket (H-site) [chemical binding]; other site 909946002700 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 909946002701 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 909946002702 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 909946002703 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 909946002704 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 909946002705 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946002706 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 909946002707 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 909946002708 active site 909946002709 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 909946002710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946002711 putative substrate translocation pore; other site 909946002712 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 909946002713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946002714 active site 909946002715 motif I; other site 909946002716 motif II; other site 909946002717 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946002718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946002719 putative substrate translocation pore; other site 909946002720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909946002721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 909946002722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946002723 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 909946002724 putative transporter; Provisional; Region: PRK04972 909946002725 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 909946002726 TrkA-C domain; Region: TrkA_C; pfam02080 909946002727 TrkA-C domain; Region: TrkA_C; pfam02080 909946002728 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 909946002729 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 909946002730 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 909946002731 GSH binding site [chemical binding]; other site 909946002732 catalytic residues [active] 909946002733 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 909946002734 RimK-like ATP-grasp domain; Region: RimK; pfam08443 909946002735 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 909946002736 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 909946002737 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 909946002738 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 909946002739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946002740 Walker A/P-loop; other site 909946002741 ATP binding site [chemical binding]; other site 909946002742 Q-loop/lid; other site 909946002743 ABC transporter signature motif; other site 909946002744 Walker B; other site 909946002745 D-loop; other site 909946002746 H-loop/switch region; other site 909946002747 TOBE domain; Region: TOBE_2; pfam08402 909946002748 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 909946002749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946002750 dimer interface [polypeptide binding]; other site 909946002751 conserved gate region; other site 909946002752 putative PBP binding loops; other site 909946002753 ABC-ATPase subunit interface; other site 909946002754 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 909946002755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946002756 dimer interface [polypeptide binding]; other site 909946002757 conserved gate region; other site 909946002758 putative PBP binding loops; other site 909946002759 ABC-ATPase subunit interface; other site 909946002760 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 909946002761 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 909946002762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946002763 S-adenosylmethionine binding site [chemical binding]; other site 909946002764 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 909946002765 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 909946002766 active site 909946002767 P-loop; other site 909946002768 phosphorylation site [posttranslational modification] 909946002769 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 909946002770 Sulfatase; Region: Sulfatase; cl17466 909946002771 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 909946002772 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946002773 substrate binding pocket [chemical binding]; other site 909946002774 membrane-bound complex binding site; other site 909946002775 hinge residues; other site 909946002776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946002777 dimer interface [polypeptide binding]; other site 909946002778 conserved gate region; other site 909946002779 putative PBP binding loops; other site 909946002780 ABC-ATPase subunit interface; other site 909946002781 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 909946002782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946002783 dimer interface [polypeptide binding]; other site 909946002784 conserved gate region; other site 909946002785 putative PBP binding loops; other site 909946002786 ABC-ATPase subunit interface; other site 909946002787 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 909946002788 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946002789 substrate binding pocket [chemical binding]; other site 909946002790 membrane-bound complex binding site; other site 909946002791 hinge residues; other site 909946002792 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 909946002793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946002794 Walker A/P-loop; other site 909946002795 ATP binding site [chemical binding]; other site 909946002796 Q-loop/lid; other site 909946002797 ABC transporter signature motif; other site 909946002798 Walker B; other site 909946002799 D-loop; other site 909946002800 H-loop/switch region; other site 909946002801 putative lipoprotein; Provisional; Region: PRK10533 909946002802 hypothetical protein; Provisional; Region: PRK02877 909946002803 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 909946002804 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 909946002805 amidase catalytic site [active] 909946002806 Zn binding residues [ion binding]; other site 909946002807 substrate binding site [chemical binding]; other site 909946002808 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 909946002809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 909946002810 NAD(P) binding site [chemical binding]; other site 909946002811 active site 909946002812 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 909946002813 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 909946002814 putative NAD(P) binding site [chemical binding]; other site 909946002815 putative active site [active] 909946002816 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 909946002817 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 909946002818 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 909946002819 tetramer interface [polypeptide binding]; other site 909946002820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946002821 catalytic residue [active] 909946002822 pyruvate dehydrogenase; Provisional; Region: PRK09124 909946002823 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 909946002824 PYR/PP interface [polypeptide binding]; other site 909946002825 dimer interface [polypeptide binding]; other site 909946002826 tetramer interface [polypeptide binding]; other site 909946002827 TPP binding site [chemical binding]; other site 909946002828 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 909946002829 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 909946002830 TPP-binding site [chemical binding]; other site 909946002831 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 909946002832 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 909946002833 FAD binding pocket [chemical binding]; other site 909946002834 FAD binding motif [chemical binding]; other site 909946002835 phosphate binding motif [ion binding]; other site 909946002836 beta-alpha-beta structure motif; other site 909946002837 NAD binding pocket [chemical binding]; other site 909946002838 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 909946002839 catalytic loop [active] 909946002840 iron binding site [ion binding]; other site 909946002841 hybrid cluster protein; Provisional; Region: PRK05290 909946002842 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 909946002843 ACS interaction site; other site 909946002844 CODH interaction site; other site 909946002845 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 909946002846 hybrid metal cluster; other site 909946002847 Predicted membrane protein [Function unknown]; Region: COG2431 909946002848 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 909946002849 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 909946002850 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 909946002851 putative active site [active] 909946002852 putative metal-binding site [ion binding]; other site 909946002853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 909946002854 macrolide transporter subunit MacA; Provisional; Region: PRK11578 909946002855 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 909946002856 HlyD family secretion protein; Region: HlyD_3; pfam13437 909946002857 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 909946002858 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 909946002859 Walker A/P-loop; other site 909946002860 ATP binding site [chemical binding]; other site 909946002861 Q-loop/lid; other site 909946002862 ABC transporter signature motif; other site 909946002863 Walker B; other site 909946002864 D-loop; other site 909946002865 H-loop/switch region; other site 909946002866 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 909946002867 FtsX-like permease family; Region: FtsX; pfam02687 909946002868 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 909946002869 DNA-binding site [nucleotide binding]; DNA binding site 909946002870 RNA-binding motif; other site 909946002871 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 909946002872 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 909946002873 Clp amino terminal domain; Region: Clp_N; pfam02861 909946002874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946002875 Walker A motif; other site 909946002876 ATP binding site [chemical binding]; other site 909946002877 Walker B motif; other site 909946002878 arginine finger; other site 909946002879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946002880 Walker A motif; other site 909946002881 ATP binding site [chemical binding]; other site 909946002882 Walker B motif; other site 909946002883 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 909946002884 Transposase IS200 like; Region: Y1_Tnp; pfam01797 909946002885 Integrase core domain; Region: rve; pfam00665 909946002886 Integrase core domain; Region: rve_3; pfam13683 909946002887 Helix-turn-helix domain; Region: HTH_28; pfam13518 909946002888 Isochorismatase family; Region: Isochorismatase; pfam00857 909946002889 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 909946002890 catalytic triad [active] 909946002891 dimer interface [polypeptide binding]; other site 909946002892 conserved cis-peptide bond; other site 909946002893 Pirin-related protein [General function prediction only]; Region: COG1741 909946002894 Pirin; Region: Pirin; pfam02678 909946002895 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 909946002896 LysR family transcriptional regulator; Provisional; Region: PRK14997 909946002897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946002898 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 909946002899 putative effector binding pocket; other site 909946002900 putative dimerization interface [polypeptide binding]; other site 909946002901 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 909946002902 rRNA binding site [nucleotide binding]; other site 909946002903 predicted 30S ribosome binding site; other site 909946002904 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 909946002905 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 909946002906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909946002907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946002908 Walker A/P-loop; other site 909946002909 ATP binding site [chemical binding]; other site 909946002910 Q-loop/lid; other site 909946002911 ABC transporter signature motif; other site 909946002912 Walker B; other site 909946002913 D-loop; other site 909946002914 H-loop/switch region; other site 909946002915 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 909946002916 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909946002917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946002918 Walker A/P-loop; other site 909946002919 ATP binding site [chemical binding]; other site 909946002920 Q-loop/lid; other site 909946002921 ABC transporter signature motif; other site 909946002922 Walker B; other site 909946002923 D-loop; other site 909946002924 H-loop/switch region; other site 909946002925 thioredoxin reductase; Provisional; Region: PRK10262 909946002926 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909946002927 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909946002928 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 909946002929 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909946002930 putative DNA binding site [nucleotide binding]; other site 909946002931 putative Zn2+ binding site [ion binding]; other site 909946002932 AsnC family; Region: AsnC_trans_reg; pfam01037 909946002933 DNA translocase FtsK; Provisional; Region: PRK10263 909946002934 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 909946002935 DNA translocase FtsK; Provisional; Region: PRK10263 909946002936 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 909946002937 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 909946002938 periplasmic chaperone LolA; Region: lolA; TIGR00547 909946002939 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 909946002940 recombination factor protein RarA; Reviewed; Region: PRK13342 909946002941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946002942 Walker A motif; other site 909946002943 ATP binding site [chemical binding]; other site 909946002944 Walker B motif; other site 909946002945 arginine finger; other site 909946002946 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 909946002947 seryl-tRNA synthetase; Provisional; Region: PRK05431 909946002948 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 909946002949 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 909946002950 dimer interface [polypeptide binding]; other site 909946002951 active site 909946002952 motif 1; other site 909946002953 motif 2; other site 909946002954 motif 3; other site 909946002955 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 909946002956 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 909946002957 putative [Fe4-S4] binding site [ion binding]; other site 909946002958 putative molybdopterin cofactor binding site [chemical binding]; other site 909946002959 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 909946002960 putative molybdopterin cofactor binding site; other site 909946002961 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 909946002962 4Fe-4S binding domain; Region: Fer4; pfam00037 909946002963 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 909946002964 putative MFS family transporter protein; Provisional; Region: PRK03633 909946002965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946002966 putative substrate translocation pore; other site 909946002967 inner membrane transporter YjeM; Provisional; Region: PRK15238 909946002968 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 909946002969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946002970 FeS/SAM binding site; other site 909946002971 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 909946002972 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 909946002973 Pyruvate formate lyase 1; Region: PFL1; cd01678 909946002974 coenzyme A binding site [chemical binding]; other site 909946002975 active site 909946002976 catalytic residues [active] 909946002977 glycine loop; other site 909946002978 formate transporter; Provisional; Region: PRK10805 909946002979 uncharacterized domain; Region: TIGR00702 909946002980 YcaO-like family; Region: YcaO; pfam02624 909946002981 Predicted membrane protein [Function unknown]; Region: COG2323 909946002982 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 909946002983 homodimer interface [polypeptide binding]; other site 909946002984 substrate-cofactor binding pocket; other site 909946002985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946002986 catalytic residue [active] 909946002987 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 909946002988 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 909946002989 hinge; other site 909946002990 active site 909946002991 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 909946002992 cytidylate kinase; Provisional; Region: cmk; PRK00023 909946002993 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 909946002994 CMP-binding site; other site 909946002995 The sites determining sugar specificity; other site 909946002996 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 909946002997 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 909946002998 RNA binding site [nucleotide binding]; other site 909946002999 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 909946003000 RNA binding site [nucleotide binding]; other site 909946003001 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 909946003002 RNA binding site [nucleotide binding]; other site 909946003003 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 909946003004 RNA binding site [nucleotide binding]; other site 909946003005 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 909946003006 RNA binding site [nucleotide binding]; other site 909946003007 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 909946003008 IHF dimer interface [polypeptide binding]; other site 909946003009 IHF - DNA interface [nucleotide binding]; other site 909946003010 ComEC family competence protein; Provisional; Region: PRK11539 909946003011 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 909946003012 Competence protein; Region: Competence; pfam03772 909946003013 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 909946003014 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 909946003015 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909946003016 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 909946003017 Walker A/P-loop; other site 909946003018 ATP binding site [chemical binding]; other site 909946003019 Q-loop/lid; other site 909946003020 ABC transporter signature motif; other site 909946003021 Walker B; other site 909946003022 D-loop; other site 909946003023 H-loop/switch region; other site 909946003024 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 909946003025 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 909946003026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 909946003027 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 909946003028 hypothetical protein; Provisional; Region: PRK11827 909946003029 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 909946003030 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 909946003031 Ligand binding site; other site 909946003032 oligomer interface; other site 909946003033 hypothetical protein; Provisional; Region: PRK10593 909946003034 Uncharacterized conserved protein [Function unknown]; Region: COG1434 909946003035 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 909946003036 putative active site [active] 909946003037 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 909946003038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946003039 S-adenosylmethionine binding site [chemical binding]; other site 909946003040 condesin subunit F; Provisional; Region: PRK05260 909946003041 condesin subunit E; Provisional; Region: PRK05256 909946003042 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 909946003043 P-loop containing region of AAA domain; Region: AAA_29; cl17516 909946003044 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 909946003045 murein L,D-transpeptidase; Provisional; Region: PRK10594 909946003046 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 909946003047 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 909946003048 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 909946003049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 909946003050 Peptidase M15; Region: Peptidase_M15_3; cl01194 909946003051 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 909946003052 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 909946003053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909946003054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946003055 homodimer interface [polypeptide binding]; other site 909946003056 catalytic residue [active] 909946003057 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 909946003058 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 909946003059 trimer interface [polypeptide binding]; other site 909946003060 eyelet of channel; other site 909946003061 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 909946003062 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 909946003063 putative dimer interface [polypeptide binding]; other site 909946003064 putative anticodon binding site; other site 909946003065 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 909946003066 homodimer interface [polypeptide binding]; other site 909946003067 motif 1; other site 909946003068 motif 2; other site 909946003069 active site 909946003070 motif 3; other site 909946003071 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 909946003072 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909946003073 putative DNA binding site [nucleotide binding]; other site 909946003074 putative Zn2+ binding site [ion binding]; other site 909946003075 AsnC family; Region: AsnC_trans_reg; pfam01037 909946003076 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 909946003077 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 909946003078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909946003079 catalytic residue [active] 909946003080 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 909946003081 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 909946003082 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 909946003083 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 909946003084 active site 909946003085 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 909946003086 RecT family; Region: RecT; pfam03837 909946003087 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 909946003088 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 909946003089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946003090 non-specific DNA binding site [nucleotide binding]; other site 909946003091 salt bridge; other site 909946003092 sequence-specific DNA binding site [nucleotide binding]; other site 909946003093 Bacteriophage CII protein; Region: Phage_CII; pfam05269 909946003094 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 909946003095 primosomal protein DnaI; Provisional; Region: PRK02854 909946003096 putative replication protein; Provisional; Region: PRK12377 909946003097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946003098 Walker A motif; other site 909946003099 ATP binding site [chemical binding]; other site 909946003100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 909946003101 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 909946003102 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 909946003103 DinI-like family; Region: DinI; pfam06183 909946003104 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 909946003105 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 909946003106 Antitermination protein; Region: Antiterm; pfam03589 909946003107 Antitermination protein; Region: Antiterm; pfam03589 909946003108 PipA protein; Region: PipA; pfam07108 909946003109 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 909946003110 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 909946003111 catalytic residues [active] 909946003112 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 909946003113 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 909946003114 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 909946003115 Domain of unknown function (DUF1859); Region: DUF1859; pfam08948 909946003116 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 909946003117 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 909946003118 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 909946003119 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 909946003120 oligomer interface [polypeptide binding]; other site 909946003121 active site residues [active] 909946003122 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 909946003123 Uncharacterized conserved protein [Function unknown]; Region: COG5471 909946003124 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 909946003125 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 909946003126 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 909946003127 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 909946003128 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 909946003129 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 909946003130 Phage-related minor tail protein [Function unknown]; Region: COG5281 909946003131 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 909946003132 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 909946003133 Phage-related protein [Function unknown]; Region: COG4718 909946003134 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 909946003135 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 909946003136 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 909946003137 E-class dimer interface [polypeptide binding]; other site 909946003138 P-class dimer interface [polypeptide binding]; other site 909946003139 active site 909946003140 Cu2+ binding site [ion binding]; other site 909946003141 Zn2+ binding site [ion binding]; other site 909946003142 Phage-related protein [Function unknown]; Region: gp18; COG4672 909946003143 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 909946003144 MPN+ (JAMM) motif; other site 909946003145 Zinc-binding site [ion binding]; other site 909946003146 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 909946003147 NlpC/P60 family; Region: NLPC_P60; cl17555 909946003148 Phage-related protein, tail component [Function unknown]; Region: COG4723 909946003149 Phage-related protein, tail component [Function unknown]; Region: COG4733 909946003150 Putative phage tail protein; Region: Phage-tail_3; pfam13550 909946003151 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 909946003152 Interdomain contacts; other site 909946003153 Cytokine receptor motif; other site 909946003154 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 909946003155 Fibronectin type III protein; Region: DUF3672; pfam12421 909946003156 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 909946003157 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 909946003158 Phage Tail Collar Domain; Region: Collar; pfam07484 909946003159 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 909946003160 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 909946003161 hypothetical protein; Provisional; Region: PRK09951 909946003162 DinI-like family; Region: DinI; cl11630 909946003163 aminopeptidase N; Provisional; Region: pepN; PRK14015 909946003164 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 909946003165 active site 909946003166 Zn binding site [ion binding]; other site 909946003167 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 909946003168 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 909946003169 quinone interaction residues [chemical binding]; other site 909946003170 active site 909946003171 catalytic residues [active] 909946003172 FMN binding site [chemical binding]; other site 909946003173 substrate binding site [chemical binding]; other site 909946003174 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 909946003175 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 909946003176 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 909946003177 MOSC domain; Region: MOSC; pfam03473 909946003178 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 909946003179 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 909946003180 catalytic loop [active] 909946003181 iron binding site [ion binding]; other site 909946003182 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 909946003183 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 909946003184 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 909946003185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946003186 S-adenosylmethionine binding site [chemical binding]; other site 909946003187 ABC transporter ATPase component; Reviewed; Region: PRK11147 909946003188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946003189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946003190 Walker A/P-loop; other site 909946003191 Walker A/P-loop; other site 909946003192 ATP binding site [chemical binding]; other site 909946003193 ATP binding site [chemical binding]; other site 909946003194 Q-loop/lid; other site 909946003195 Q-loop/lid; other site 909946003196 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909946003197 ABC transporter signature motif; other site 909946003198 Walker B; other site 909946003199 D-loop; other site 909946003200 ABC transporter; Region: ABC_tran_2; pfam12848 909946003201 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909946003202 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 909946003203 Paraquat-inducible protein A; Region: PqiA; pfam04403 909946003204 Paraquat-inducible protein A; Region: PqiA; pfam04403 909946003205 paraquat-inducible protein B; Provisional; Region: PRK10807 909946003206 mce related protein; Region: MCE; pfam02470 909946003207 mce related protein; Region: MCE; pfam02470 909946003208 mce related protein; Region: MCE; pfam02470 909946003209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 909946003210 Protein of unknown function (DUF330); Region: DUF330; pfam03886 909946003211 ribosome modulation factor; Provisional; Region: PRK14563 909946003212 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 909946003213 active site 1 [active] 909946003214 dimer interface [polypeptide binding]; other site 909946003215 active site 2 [active] 909946003216 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 909946003217 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 909946003218 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 909946003219 outer membrane protein A; Reviewed; Region: PRK10808 909946003220 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 909946003221 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 909946003222 ligand binding site [chemical binding]; other site 909946003223 cell division inhibitor SulA; Region: sula; TIGR00623 909946003224 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 909946003225 TfoX C-terminal domain; Region: TfoX_C; pfam04994 909946003226 TIGR01666 family membrane protein; Region: YCCS 909946003227 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 909946003228 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 909946003229 Predicted membrane protein [Function unknown]; Region: COG3304 909946003230 Domain of unknown function (DUF307); Region: DUF307; pfam03733 909946003231 Domain of unknown function (DUF307); Region: DUF307; pfam03733 909946003232 DNA helicase IV; Provisional; Region: helD; PRK11054 909946003233 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 909946003234 Part of AAA domain; Region: AAA_19; pfam13245 909946003235 Family description; Region: UvrD_C_2; pfam13538 909946003236 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 909946003237 active site 909946003238 dimer interfaces [polypeptide binding]; other site 909946003239 catalytic residues [active] 909946003240 hypothetical protein; Provisional; Region: PRK03641 909946003241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 909946003242 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 909946003243 heat shock protein HspQ; Provisional; Region: PRK14129 909946003244 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 909946003245 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 909946003246 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 909946003247 putative RNA binding site [nucleotide binding]; other site 909946003248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946003249 S-adenosylmethionine binding site [chemical binding]; other site 909946003250 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 909946003251 substrate binding site [chemical binding]; other site 909946003252 Cupin domain; Region: Cupin_2; cl17218 909946003253 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 909946003254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946003255 acylphosphatase; Provisional; Region: PRK14426 909946003256 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 909946003257 sulfur transfer protein TusE; Provisional; Region: PRK11508 909946003258 YccA-like proteins; Region: YccA_like; cd10433 909946003259 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 909946003260 PipA protein; Region: PipA; pfam07108 909946003261 secreted effector protein PipB; Provisional; Region: PRK15197 909946003262 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 909946003263 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 909946003264 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 909946003265 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 909946003266 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 909946003267 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 909946003268 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 909946003269 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 909946003270 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 909946003271 HAMP domain; Region: HAMP; pfam00672 909946003272 dimerization interface [polypeptide binding]; other site 909946003273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946003274 dimer interface [polypeptide binding]; other site 909946003275 phosphorylation site [posttranslational modification] 909946003276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946003277 ATP binding site [chemical binding]; other site 909946003278 Mg2+ binding site [ion binding]; other site 909946003279 G-X-G motif; other site 909946003280 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 909946003281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946003282 active site 909946003283 phosphorylation site [posttranslational modification] 909946003284 intermolecular recognition site; other site 909946003285 dimerization interface [polypeptide binding]; other site 909946003286 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946003287 DNA binding site [nucleotide binding] 909946003288 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 909946003289 active site 909946003290 homotetramer interface [polypeptide binding]; other site 909946003291 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 909946003292 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 909946003293 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 909946003294 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 909946003295 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 909946003296 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 909946003297 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 909946003298 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 909946003299 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 909946003300 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 909946003301 NAD binding site [chemical binding]; other site 909946003302 catalytic residues [active] 909946003303 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 909946003304 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 909946003305 putative active site [active] 909946003306 putative metal binding site [ion binding]; other site 909946003307 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 909946003308 putative substrate binding pocket [chemical binding]; other site 909946003309 trimer interface [polypeptide binding]; other site 909946003310 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 909946003311 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 909946003312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946003313 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 909946003314 putative substrate translocation pore; other site 909946003315 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 909946003316 Cupin domain; Region: Cupin_2; pfam07883 909946003317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946003318 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 909946003319 anti-adapter protein IraM; Provisional; Region: PRK09919 909946003320 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 909946003321 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 909946003322 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 909946003323 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 909946003324 HSP70 interaction site [polypeptide binding]; other site 909946003325 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 909946003326 substrate binding site [polypeptide binding]; other site 909946003327 dimer interface [polypeptide binding]; other site 909946003328 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 909946003329 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 909946003330 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 909946003331 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 909946003332 DsbD alpha interface [polypeptide binding]; other site 909946003333 catalytic residues [active] 909946003334 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 909946003335 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 909946003336 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 909946003337 catalytic residues [active] 909946003338 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 909946003339 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 909946003340 catalytic residues [active] 909946003341 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 909946003342 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 909946003343 catalytic core [active] 909946003344 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 909946003345 hypothetical protein; Provisional; Region: PRK10174 909946003346 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 909946003347 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 909946003348 General stress protein [General function prediction only]; Region: GsiB; COG3729 909946003349 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 909946003350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946003351 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 909946003352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 909946003353 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 909946003354 Predicted transcriptional regulator [Transcription]; Region: COG3905 909946003355 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 909946003356 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 909946003357 Glutamate binding site [chemical binding]; other site 909946003358 NAD binding site [chemical binding]; other site 909946003359 catalytic residues [active] 909946003360 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 909946003361 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 909946003362 Na binding site [ion binding]; other site 909946003363 hypothetical protein; Provisional; Region: PRK10536 909946003364 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 909946003365 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 909946003366 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 909946003367 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 909946003368 putative active site [active] 909946003369 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 909946003370 Na binding site [ion binding]; other site 909946003371 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 909946003372 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 909946003373 putative active site cavity [active] 909946003374 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 909946003375 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 909946003376 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 909946003377 putative sialic acid transporter; Provisional; Region: PRK12307 909946003378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946003379 putative substrate translocation pore; other site 909946003380 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 909946003381 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909946003382 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909946003383 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 909946003384 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 909946003385 putative ligand binding site [chemical binding]; other site 909946003386 NAD binding site [chemical binding]; other site 909946003387 dimerization interface [polypeptide binding]; other site 909946003388 catalytic site [active] 909946003389 putative hydrolase; Validated; Region: PRK09248 909946003390 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 909946003391 active site 909946003392 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 909946003393 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 909946003394 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 909946003395 curli assembly protein CsgF; Provisional; Region: PRK10050 909946003396 curli assembly protein CsgE; Provisional; Region: PRK10386 909946003397 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 909946003398 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946003399 DNA binding residues [nucleotide binding] 909946003400 dimerization interface [polypeptide binding]; other site 909946003401 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 909946003402 Curlin associated repeat; Region: Curlin_rpt; pfam07012 909946003403 Curlin associated repeat; Region: Curlin_rpt; pfam07012 909946003404 major curlin subunit; Provisional; Region: csgA; PRK10051 909946003405 Curlin associated repeat; Region: Curlin_rpt; pfam07012 909946003406 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 909946003407 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 909946003408 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 909946003409 putative ADP-ribose binding site [chemical binding]; other site 909946003410 putative active site [active] 909946003411 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 909946003412 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 909946003413 putative active site [active] 909946003414 catalytic site [active] 909946003415 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 909946003416 putative active site [active] 909946003417 catalytic site [active] 909946003418 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 909946003419 Acyltransferase family; Region: Acyl_transf_3; pfam01757 909946003420 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 909946003421 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 909946003422 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 909946003423 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 909946003424 Ligand binding site; other site 909946003425 DXD motif; other site 909946003426 lipoprotein; Provisional; Region: PRK10175 909946003427 secY/secA suppressor protein; Provisional; Region: PRK11467 909946003428 drug efflux system protein MdtG; Provisional; Region: PRK09874 909946003429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946003430 putative substrate translocation pore; other site 909946003431 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 909946003432 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 909946003433 putative acyl-acceptor binding pocket; other site 909946003434 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 909946003435 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 909946003436 active site residue [active] 909946003437 hypothetical protein; Provisional; Region: PRK03757 909946003438 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 909946003439 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 909946003440 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 909946003441 hydroxyglutarate oxidase; Provisional; Region: PRK11728 909946003442 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 909946003443 DNA damage-inducible protein I; Provisional; Region: PRK10597 909946003444 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 909946003445 active site 909946003446 substrate binding pocket [chemical binding]; other site 909946003447 dimer interface [polypeptide binding]; other site 909946003448 lipoprotein; Provisional; Region: PRK10598 909946003449 glutaredoxin 2; Provisional; Region: PRK10387 909946003450 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 909946003451 C-terminal domain interface [polypeptide binding]; other site 909946003452 GSH binding site (G-site) [chemical binding]; other site 909946003453 catalytic residues [active] 909946003454 putative dimer interface [polypeptide binding]; other site 909946003455 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 909946003456 N-terminal domain interface [polypeptide binding]; other site 909946003457 multidrug resistance protein MdtH; Provisional; Region: PRK11646 909946003458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946003459 putative substrate translocation pore; other site 909946003460 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 909946003461 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 909946003462 hypothetical protein; Provisional; Region: PRK11239 909946003463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 909946003464 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 909946003465 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909946003466 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909946003467 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 909946003468 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 909946003469 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 909946003470 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 909946003471 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 909946003472 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 909946003473 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 909946003474 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 909946003475 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 909946003476 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 909946003477 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 909946003478 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 909946003479 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 909946003480 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 909946003481 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 909946003482 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 909946003483 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 909946003484 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 909946003485 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 909946003486 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 909946003487 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 909946003488 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 909946003489 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 909946003490 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 909946003491 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 909946003492 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 909946003493 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 909946003494 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 909946003495 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 909946003496 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 909946003497 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 909946003498 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 909946003499 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 909946003500 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 909946003501 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 909946003502 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 909946003503 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 909946003504 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 909946003505 homodimer interface [polypeptide binding]; other site 909946003506 oligonucleotide binding site [chemical binding]; other site 909946003507 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 909946003508 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 909946003509 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909946003510 RNA binding surface [nucleotide binding]; other site 909946003511 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 909946003512 active site 909946003513 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 909946003514 Maf-like protein; Region: Maf; pfam02545 909946003515 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 909946003516 active site 909946003517 dimer interface [polypeptide binding]; other site 909946003518 hypothetical protein; Provisional; Region: PRK11193 909946003519 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 909946003520 putative phosphate acyltransferase; Provisional; Region: PRK05331 909946003521 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 909946003522 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 909946003523 dimer interface [polypeptide binding]; other site 909946003524 active site 909946003525 CoA binding pocket [chemical binding]; other site 909946003526 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 909946003527 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 909946003528 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 909946003529 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 909946003530 NAD(P) binding site [chemical binding]; other site 909946003531 homotetramer interface [polypeptide binding]; other site 909946003532 homodimer interface [polypeptide binding]; other site 909946003533 active site 909946003534 acyl carrier protein; Provisional; Region: acpP; PRK00982 909946003535 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 909946003536 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 909946003537 dimer interface [polypeptide binding]; other site 909946003538 active site 909946003539 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 909946003540 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 909946003541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946003542 catalytic residue [active] 909946003543 conserved hypothetical protein, YceG family; Region: TIGR00247 909946003544 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 909946003545 dimerization interface [polypeptide binding]; other site 909946003546 thymidylate kinase; Validated; Region: tmk; PRK00698 909946003547 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 909946003548 TMP-binding site; other site 909946003549 ATP-binding site [chemical binding]; other site 909946003550 DNA polymerase III subunit delta'; Validated; Region: PRK07993 909946003551 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 909946003552 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 909946003553 active site 909946003554 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 909946003555 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 909946003556 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 909946003557 active site turn [active] 909946003558 phosphorylation site [posttranslational modification] 909946003559 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 909946003560 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 909946003561 N-terminal plug; other site 909946003562 ligand-binding site [chemical binding]; other site 909946003563 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 909946003564 nucleotide binding site/active site [active] 909946003565 HIT family signature motif; other site 909946003566 catalytic residue [active] 909946003567 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 909946003568 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 909946003569 putative dimer interface [polypeptide binding]; other site 909946003570 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 909946003571 thiamine kinase; Region: ycfN_thiK; TIGR02721 909946003572 thiamine kinase; Provisional; Region: thiK; PRK10271 909946003573 substrate binding site [chemical binding]; other site 909946003574 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 909946003575 beta-hexosaminidase; Provisional; Region: PRK05337 909946003576 hypothetical protein; Provisional; Region: PRK04940 909946003577 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 909946003578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909946003579 hypothetical protein; Provisional; Region: PRK11280 909946003580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909946003581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946003582 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 909946003583 L,D-transpeptidase; Provisional; Region: PRK10190 909946003584 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 909946003585 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 909946003586 transcription-repair coupling factor; Provisional; Region: PRK10689 909946003587 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 909946003588 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909946003589 ATP binding site [chemical binding]; other site 909946003590 putative Mg++ binding site [ion binding]; other site 909946003591 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946003592 nucleotide binding region [chemical binding]; other site 909946003593 ATP-binding site [chemical binding]; other site 909946003594 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 909946003595 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 909946003596 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 909946003597 FtsX-like permease family; Region: FtsX; pfam02687 909946003598 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 909946003599 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 909946003600 Walker A/P-loop; other site 909946003601 ATP binding site [chemical binding]; other site 909946003602 Q-loop/lid; other site 909946003603 ABC transporter signature motif; other site 909946003604 Walker B; other site 909946003605 D-loop; other site 909946003606 H-loop/switch region; other site 909946003607 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 909946003608 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 909946003609 FtsX-like permease family; Region: FtsX; pfam02687 909946003610 fructokinase; Reviewed; Region: PRK09557 909946003611 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 909946003612 nucleotide binding site [chemical binding]; other site 909946003613 NAD-dependent deacetylase; Provisional; Region: PRK00481 909946003614 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 909946003615 NAD+ binding site [chemical binding]; other site 909946003616 substrate binding site [chemical binding]; other site 909946003617 Zn binding site [ion binding]; other site 909946003618 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 909946003619 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 909946003620 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 909946003621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946003622 dimer interface [polypeptide binding]; other site 909946003623 conserved gate region; other site 909946003624 putative PBP binding loops; other site 909946003625 ABC-ATPase subunit interface; other site 909946003626 Sif protein; Region: Sif; pfam06767 909946003627 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 909946003628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946003629 dimer interface [polypeptide binding]; other site 909946003630 conserved gate region; other site 909946003631 putative PBP binding loops; other site 909946003632 ABC-ATPase subunit interface; other site 909946003633 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 909946003634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946003635 Walker A/P-loop; other site 909946003636 ATP binding site [chemical binding]; other site 909946003637 Q-loop/lid; other site 909946003638 ABC transporter signature motif; other site 909946003639 Walker B; other site 909946003640 D-loop; other site 909946003641 H-loop/switch region; other site 909946003642 TOBE domain; Region: TOBE_2; pfam08402 909946003643 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 909946003644 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 909946003645 metal binding site [ion binding]; metal-binding site 909946003646 dimer interface [polypeptide binding]; other site 909946003647 Transposase IS200 like; Region: Y1_Tnp; pfam01797 909946003648 Uncharacterized conserved protein [Function unknown]; Region: COG2850 909946003649 Cupin-like domain; Region: Cupin_8; pfam13621 909946003650 sensor protein PhoQ; Provisional; Region: PRK10815 909946003651 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 909946003652 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 909946003653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946003654 ATP binding site [chemical binding]; other site 909946003655 Mg2+ binding site [ion binding]; other site 909946003656 G-X-G motif; other site 909946003657 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 909946003658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946003659 active site 909946003660 phosphorylation site [posttranslational modification] 909946003661 intermolecular recognition site; other site 909946003662 dimerization interface [polypeptide binding]; other site 909946003663 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946003664 DNA binding site [nucleotide binding] 909946003665 adenylosuccinate lyase; Provisional; Region: PRK09285 909946003666 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 909946003667 tetramer interface [polypeptide binding]; other site 909946003668 active site 909946003669 putative lysogenization regulator; Reviewed; Region: PRK00218 909946003670 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 909946003671 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 909946003672 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 909946003673 nudix motif; other site 909946003674 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 909946003675 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 909946003676 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 909946003677 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 909946003678 probable active site [active] 909946003679 isocitrate dehydrogenase; Validated; Region: PRK07362 909946003680 isocitrate dehydrogenase; Reviewed; Region: PRK07006 909946003681 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 909946003682 DinI-like family; Region: DinI; pfam06183 909946003683 Ricin-type beta-trefoil; Region: RICIN; smart00458 909946003684 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 909946003685 putative sugar binding sites [chemical binding]; other site 909946003686 Q-X-W motif; other site 909946003687 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 909946003688 DNA-binding site [nucleotide binding]; DNA binding site 909946003689 RNA-binding motif; other site 909946003690 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 909946003691 lysozyme inhibitor; Provisional; Region: PRK13791 909946003692 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 909946003693 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 909946003694 putative dimer interface [polypeptide binding]; other site 909946003695 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 909946003696 BNR repeat-like domain; Region: BNR_2; pfam13088 909946003697 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 909946003698 TRL-like protein family; Region: TRL; pfam13146 909946003699 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 909946003700 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 909946003701 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 909946003702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946003703 dimer interface [polypeptide binding]; other site 909946003704 conserved gate region; other site 909946003705 ABC-ATPase subunit interface; other site 909946003706 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 909946003707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946003708 dimer interface [polypeptide binding]; other site 909946003709 conserved gate region; other site 909946003710 putative PBP binding loops; other site 909946003711 ABC-ATPase subunit interface; other site 909946003712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909946003713 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 909946003714 Walker A/P-loop; other site 909946003715 ATP binding site [chemical binding]; other site 909946003716 Q-loop/lid; other site 909946003717 ABC transporter signature motif; other site 909946003718 Walker B; other site 909946003719 D-loop; other site 909946003720 H-loop/switch region; other site 909946003721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946003722 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 909946003723 Walker A/P-loop; other site 909946003724 ATP binding site [chemical binding]; other site 909946003725 Q-loop/lid; other site 909946003726 ABC transporter signature motif; other site 909946003727 Walker B; other site 909946003728 D-loop; other site 909946003729 H-loop/switch region; other site 909946003730 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 909946003731 Mechanosensitive ion channel; Region: MS_channel; pfam00924 909946003732 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 909946003733 dimerization interface [polypeptide binding]; other site 909946003734 zinc/cadmium-binding protein; Provisional; Region: PRK10306 909946003735 aminoglycoside resistance protein; Provisional; Region: PRK13746 909946003736 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 909946003737 active site 909946003738 NTP binding site [chemical binding]; other site 909946003739 metal binding triad [ion binding]; metal-binding site 909946003740 antibiotic binding site [chemical binding]; other site 909946003741 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 909946003742 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946003743 DNA binding residues [nucleotide binding] 909946003744 transcriptional regulator MirA; Provisional; Region: PRK15043 909946003745 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 909946003746 DNA binding residues [nucleotide binding] 909946003747 dimer interface [polypeptide binding]; other site 909946003748 Pleckstrin homology-like domain; Region: PH-like; cl17171 909946003749 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 909946003750 chorismate mutase; Provisional; Region: PRK08055 909946003751 leucine export protein LeuE; Provisional; Region: PRK10958 909946003752 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 909946003753 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 909946003754 hypothetical protein; Provisional; Region: PRK10457 909946003755 hypothetical protein; Provisional; Region: PRK14760 909946003756 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 909946003757 murein hydrolase B; Provisional; Region: PRK10760; cl17906 909946003758 Domain of unknown function (DUF333); Region: DUF333; pfam03891 909946003759 Uncharacterized conserved protein [Function unknown]; Region: COG3189 909946003760 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 909946003761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946003762 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 909946003763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946003764 Predicted membrane protein [Function unknown]; Region: COG2707 909946003765 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 909946003766 putative deacylase active site [active] 909946003767 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 909946003768 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 909946003769 metal binding site [ion binding]; metal-binding site 909946003770 active site 909946003771 I-site; other site 909946003772 hypothetical protein; Provisional; Region: PRK05325 909946003773 PrkA family serine protein kinase; Provisional; Region: PRK15455 909946003774 AAA ATPase domain; Region: AAA_16; pfam13191 909946003775 Walker A motif; other site 909946003776 ATP binding site [chemical binding]; other site 909946003777 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 909946003778 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 909946003779 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 909946003780 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946003781 FeS/SAM binding site; other site 909946003782 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 909946003783 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909946003784 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909946003785 active site 909946003786 catalytic tetrad [active] 909946003787 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 909946003788 active site 909946003789 phosphate binding residues; other site 909946003790 catalytic residues [active] 909946003791 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 909946003792 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 909946003793 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 909946003794 methionine sulfoxide reductase B; Provisional; Region: PRK00222 909946003795 SelR domain; Region: SelR; pfam01641 909946003796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 909946003797 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 909946003798 Isochorismatase family; Region: Isochorismatase; pfam00857 909946003799 catalytic triad [active] 909946003800 metal binding site [ion binding]; metal-binding site 909946003801 conserved cis-peptide bond; other site 909946003802 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 909946003803 active site 909946003804 homodimer interface [polypeptide binding]; other site 909946003805 protease 4; Provisional; Region: PRK10949 909946003806 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 909946003807 tandem repeat interface [polypeptide binding]; other site 909946003808 oligomer interface [polypeptide binding]; other site 909946003809 active site residues [active] 909946003810 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 909946003811 tandem repeat interface [polypeptide binding]; other site 909946003812 oligomer interface [polypeptide binding]; other site 909946003813 active site residues [active] 909946003814 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 909946003815 putative FMN binding site [chemical binding]; other site 909946003816 selenophosphate synthetase; Provisional; Region: PRK00943 909946003817 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 909946003818 dimerization interface [polypeptide binding]; other site 909946003819 putative ATP binding site [chemical binding]; other site 909946003820 DNA topoisomerase III; Provisional; Region: PRK07726 909946003821 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 909946003822 active site 909946003823 putative interdomain interaction site [polypeptide binding]; other site 909946003824 putative metal-binding site [ion binding]; other site 909946003825 putative nucleotide binding site [chemical binding]; other site 909946003826 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 909946003827 domain I; other site 909946003828 DNA binding groove [nucleotide binding] 909946003829 phosphate binding site [ion binding]; other site 909946003830 domain II; other site 909946003831 domain III; other site 909946003832 nucleotide binding site [chemical binding]; other site 909946003833 catalytic site [active] 909946003834 domain IV; other site 909946003835 glutamate dehydrogenase; Provisional; Region: PRK09414 909946003836 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 909946003837 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 909946003838 NAD(P) binding site [chemical binding]; other site 909946003839 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 909946003840 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 909946003841 active site 909946003842 8-oxo-dGMP binding site [chemical binding]; other site 909946003843 nudix motif; other site 909946003844 metal binding site [ion binding]; metal-binding site 909946003845 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 909946003846 putative catalytic site [active] 909946003847 putative phosphate binding site [ion binding]; other site 909946003848 active site 909946003849 metal binding site A [ion binding]; metal-binding site 909946003850 DNA binding site [nucleotide binding] 909946003851 putative AP binding site [nucleotide binding]; other site 909946003852 putative metal binding site B [ion binding]; other site 909946003853 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 909946003854 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 909946003855 inhibitor-cofactor binding pocket; inhibition site 909946003856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946003857 catalytic residue [active] 909946003858 arginine succinyltransferase; Provisional; Region: PRK10456 909946003859 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 909946003860 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 909946003861 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 909946003862 NAD(P) binding site [chemical binding]; other site 909946003863 catalytic residues [active] 909946003864 succinylarginine dihydrolase; Provisional; Region: PRK13281 909946003865 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 909946003866 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 909946003867 putative active site [active] 909946003868 Zn binding site [ion binding]; other site 909946003869 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 909946003870 dimer interface [polypeptide binding]; other site 909946003871 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 909946003872 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 909946003873 GIY-YIG motif/motif A; other site 909946003874 active site 909946003875 catalytic site [active] 909946003876 putative DNA binding site [nucleotide binding]; other site 909946003877 metal binding site [ion binding]; metal-binding site 909946003878 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 909946003879 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 909946003880 homodimer interface [polypeptide binding]; other site 909946003881 NAD binding pocket [chemical binding]; other site 909946003882 ATP binding pocket [chemical binding]; other site 909946003883 Mg binding site [ion binding]; other site 909946003884 active-site loop [active] 909946003885 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 909946003886 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 909946003887 active site 909946003888 P-loop; other site 909946003889 phosphorylation site [posttranslational modification] 909946003890 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 909946003891 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 909946003892 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 909946003893 methionine cluster; other site 909946003894 active site 909946003895 phosphorylation site [posttranslational modification] 909946003896 metal binding site [ion binding]; metal-binding site 909946003897 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 909946003898 Cupin domain; Region: Cupin_2; pfam07883 909946003899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946003900 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 909946003901 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 909946003902 NAD binding site [chemical binding]; other site 909946003903 sugar binding site [chemical binding]; other site 909946003904 divalent metal binding site [ion binding]; other site 909946003905 tetramer (dimer of dimers) interface [polypeptide binding]; other site 909946003906 dimer interface [polypeptide binding]; other site 909946003907 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 909946003908 putative active site [active] 909946003909 YdjC motif; other site 909946003910 Mg binding site [ion binding]; other site 909946003911 putative homodimer interface [polypeptide binding]; other site 909946003912 hydroperoxidase II; Provisional; Region: katE; PRK11249 909946003913 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 909946003914 tetramer interface [polypeptide binding]; other site 909946003915 heme binding pocket [chemical binding]; other site 909946003916 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 909946003917 domain interactions; other site 909946003918 cell division modulator; Provisional; Region: PRK10113 909946003919 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 909946003920 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 909946003921 inner membrane protein; Provisional; Region: PRK11648 909946003922 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 909946003923 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 909946003924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946003925 motif II; other site 909946003926 YniB-like protein; Region: YniB; pfam14002 909946003927 Phosphotransferase enzyme family; Region: APH; pfam01636 909946003928 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 909946003929 active site 909946003930 ATP binding site [chemical binding]; other site 909946003931 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 909946003932 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 909946003933 6-phosphofructokinase 2; Provisional; Region: PRK10294 909946003934 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 909946003935 putative substrate binding site [chemical binding]; other site 909946003936 putative ATP binding site [chemical binding]; other site 909946003937 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 909946003938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 909946003939 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 909946003940 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 909946003941 active site 909946003942 substrate binding site [chemical binding]; other site 909946003943 Mg2+ binding site [ion binding]; other site 909946003944 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 909946003945 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 909946003946 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 909946003947 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 909946003948 active site 909946003949 dimer interface [polypeptide binding]; other site 909946003950 motif 1; other site 909946003951 motif 2; other site 909946003952 motif 3; other site 909946003953 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 909946003954 anticodon binding site; other site 909946003955 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 909946003956 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 909946003957 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 909946003958 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 909946003959 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 909946003960 23S rRNA binding site [nucleotide binding]; other site 909946003961 L21 binding site [polypeptide binding]; other site 909946003962 L13 binding site [polypeptide binding]; other site 909946003963 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 909946003964 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 909946003965 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 909946003966 dimer interface [polypeptide binding]; other site 909946003967 motif 1; other site 909946003968 active site 909946003969 motif 2; other site 909946003970 motif 3; other site 909946003971 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 909946003972 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 909946003973 putative tRNA-binding site [nucleotide binding]; other site 909946003974 B3/4 domain; Region: B3_4; pfam03483 909946003975 tRNA synthetase B5 domain; Region: B5; smart00874 909946003976 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 909946003977 dimer interface [polypeptide binding]; other site 909946003978 motif 1; other site 909946003979 motif 3; other site 909946003980 motif 2; other site 909946003981 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 909946003982 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 909946003983 IHF dimer interface [polypeptide binding]; other site 909946003984 IHF - DNA interface [nucleotide binding]; other site 909946003985 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 909946003986 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909946003987 ABC-ATPase subunit interface; other site 909946003988 dimer interface [polypeptide binding]; other site 909946003989 putative PBP binding regions; other site 909946003990 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 909946003991 catalytic residues [active] 909946003992 dimer interface [polypeptide binding]; other site 909946003993 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 909946003994 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 909946003995 Walker A/P-loop; other site 909946003996 ATP binding site [chemical binding]; other site 909946003997 Q-loop/lid; other site 909946003998 ABC transporter signature motif; other site 909946003999 Walker B; other site 909946004000 D-loop; other site 909946004001 H-loop/switch region; other site 909946004002 NlpC/P60 family; Region: NLPC_P60; pfam00877 909946004003 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 909946004004 Uncharacterized conserved protein [Function unknown]; Region: COG0397 909946004005 hypothetical protein; Validated; Region: PRK00029 909946004006 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 909946004007 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 909946004008 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 909946004009 PEP synthetase regulatory protein; Provisional; Region: PRK05339 909946004010 phosphoenolpyruvate synthase; Validated; Region: PRK06464 909946004011 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 909946004012 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 909946004013 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 909946004014 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 909946004015 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 909946004016 acyl-activating enzyme (AAE) consensus motif; other site 909946004017 putative AMP binding site [chemical binding]; other site 909946004018 putative active site [active] 909946004019 putative CoA binding site [chemical binding]; other site 909946004020 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 909946004021 oxidoreductase; Provisional; Region: PRK10015 909946004022 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 909946004023 Electron transfer flavoprotein domain; Region: ETF; smart00893 909946004024 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 909946004025 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 909946004026 Ligand binding site [chemical binding]; other site 909946004027 Electron transfer flavoprotein domain; Region: ETF; pfam01012 909946004028 Cupin domain; Region: Cupin_2; pfam07883 909946004029 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 909946004030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946004031 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 909946004032 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 909946004033 active site 909946004034 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 909946004035 Coenzyme A transferase; Region: CoA_trans; smart00882 909946004036 Coenzyme A transferase; Region: CoA_trans; cl17247 909946004037 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 909946004038 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 909946004039 active site 909946004040 catalytic residue [active] 909946004041 dimer interface [polypeptide binding]; other site 909946004042 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 909946004043 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 909946004044 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 909946004045 shikimate binding site; other site 909946004046 NAD(P) binding site [chemical binding]; other site 909946004047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946004048 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909946004049 putative substrate translocation pore; other site 909946004050 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 909946004051 putative inner membrane protein; Provisional; Region: PRK10983 909946004052 Domain of unknown function DUF20; Region: UPF0118; pfam01594 909946004053 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 909946004054 FAD binding domain; Region: FAD_binding_4; pfam01565 909946004055 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 909946004056 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 909946004057 CoenzymeA binding site [chemical binding]; other site 909946004058 subunit interaction site [polypeptide binding]; other site 909946004059 PHB binding site; other site 909946004060 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 909946004061 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 909946004062 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 909946004063 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 909946004064 putative ABC transporter; Region: ycf24; CHL00085 909946004065 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 909946004066 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 909946004067 Walker A/P-loop; other site 909946004068 ATP binding site [chemical binding]; other site 909946004069 Q-loop/lid; other site 909946004070 ABC transporter signature motif; other site 909946004071 Walker B; other site 909946004072 D-loop; other site 909946004073 H-loop/switch region; other site 909946004074 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 909946004075 FeS assembly protein SufD; Region: sufD; TIGR01981 909946004076 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 909946004077 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 909946004078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909946004079 catalytic residue [active] 909946004080 cysteine desufuration protein SufE; Provisional; Region: PRK09296 909946004081 L,D-transpeptidase; Provisional; Region: PRK10190 909946004082 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 909946004083 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 909946004084 murein lipoprotein; Provisional; Region: PRK15396 909946004085 murein lipoprotein; Provisional; Region: PRK15396 909946004086 pyruvate kinase; Provisional; Region: PRK09206 909946004087 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 909946004088 domain interfaces; other site 909946004089 active site 909946004090 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 909946004091 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 909946004092 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 909946004093 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909946004094 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 909946004095 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909946004096 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 909946004097 substrate binding site [chemical binding]; other site 909946004098 dimer interface [polypeptide binding]; other site 909946004099 ATP binding site [chemical binding]; other site 909946004100 tetrathionate reductase subunit A; Provisional; Region: PRK14991 909946004101 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 909946004102 putative [Fe4-S4] binding site [ion binding]; other site 909946004103 putative molybdopterin cofactor binding site [chemical binding]; other site 909946004104 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 909946004105 putative molybdopterin cofactor binding site; other site 909946004106 tetrathionate reductase subunit C; Provisional; Region: PRK14992 909946004107 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 909946004108 tetrathionate reductase subunit B; Provisional; Region: PRK14993 909946004109 4Fe-4S binding domain; Region: Fer4; pfam00037 909946004110 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 909946004111 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 909946004112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 909946004113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946004114 dimer interface [polypeptide binding]; other site 909946004115 phosphorylation site [posttranslational modification] 909946004116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946004117 ATP binding site [chemical binding]; other site 909946004118 Mg2+ binding site [ion binding]; other site 909946004119 G-X-G motif; other site 909946004120 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 909946004121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946004122 active site 909946004123 phosphorylation site [posttranslational modification] 909946004124 intermolecular recognition site; other site 909946004125 dimerization interface [polypeptide binding]; other site 909946004126 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946004127 DNA binding residues [nucleotide binding] 909946004128 dimerization interface [polypeptide binding]; other site 909946004129 hypothetical protein; Provisional; Region: PRK10292 909946004130 Uncharacterized conserved protein [Function unknown]; Region: COG1683 909946004131 Uncharacterized conserved protein [Function unknown]; Region: COG3272 909946004132 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 909946004133 transcriptional regulator MirA; Provisional; Region: PRK15043 909946004134 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 909946004135 DNA binding residues [nucleotide binding] 909946004136 two component system sensor kinase SsrB; Provisional; Region: PRK15369 909946004137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946004138 active site 909946004139 phosphorylation site [posttranslational modification] 909946004140 intermolecular recognition site; other site 909946004141 dimerization interface [polypeptide binding]; other site 909946004142 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946004143 DNA binding residues [nucleotide binding] 909946004144 dimerization interface [polypeptide binding]; other site 909946004145 two component system sensor kinase SsrA; Provisional; Region: PRK15347 909946004146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946004147 dimerization interface [polypeptide binding]; other site 909946004148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946004149 dimer interface [polypeptide binding]; other site 909946004150 phosphorylation site [posttranslational modification] 909946004151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946004152 ATP binding site [chemical binding]; other site 909946004153 Mg2+ binding site [ion binding]; other site 909946004154 G-X-G motif; other site 909946004155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946004156 active site 909946004157 phosphorylation site [posttranslational modification] 909946004158 intermolecular recognition site; other site 909946004159 dimerization interface [polypeptide binding]; other site 909946004160 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 909946004161 outer membrane secretin SsaC; Provisional; Region: PRK15346 909946004162 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 909946004163 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 909946004164 type III secretion system protein SsaD; Provisional; Region: PRK15367 909946004165 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 909946004166 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 909946004167 type III secretion system chaperone SseA; Provisional; Region: PRK15365 909946004168 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 909946004169 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 909946004170 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 909946004171 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 909946004172 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 909946004173 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 909946004174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 909946004175 TPR motif; other site 909946004176 binding surface 909946004177 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 909946004178 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 909946004179 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 909946004180 type III secretion system protein SsaH; Provisional; Region: PRK15356 909946004181 type III secretion system protein SsaI; Provisional; Region: PRK15355 909946004182 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 909946004183 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 909946004184 type III secretion system protein SsaK; Provisional; Region: PRK15354 909946004185 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 909946004186 type III secretion system protein SsaL; Provisional; Region: PRK15345 909946004187 HrpJ-like domain; Region: HrpJ; pfam07201 909946004188 TyeA; Region: TyeA; cl07611 909946004189 type III secretion system protein SsaM; Provisional; Region: PRK15353 909946004190 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 909946004191 FHIPEP family; Region: FHIPEP; pfam00771 909946004192 type III secretion system ATPase SsaN; Validated; Region: PRK07594 909946004193 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 909946004194 Walker A motif; other site 909946004195 ATP binding site [chemical binding]; other site 909946004196 Walker B motif; other site 909946004197 type III secretion system protein SsaO; Provisional; Region: PRK15352 909946004198 type III secretion system protein SsaP; Provisional; Region: PRK15351 909946004199 type III secretion system protein SsaQ; Validated; Region: PRK08035 909946004200 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 909946004201 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 909946004202 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 909946004203 type III secretion system protein SsaS; Provisional; Region: PRK15350 909946004204 type III secretion system protein SsaT; Provisional; Region: PRK15349 909946004205 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 909946004206 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 909946004207 multidrug efflux protein; Reviewed; Region: PRK01766 909946004208 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 909946004209 cation binding site [ion binding]; other site 909946004210 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 909946004211 Lumazine binding domain; Region: Lum_binding; pfam00677 909946004212 Lumazine binding domain; Region: Lum_binding; pfam00677 909946004213 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 909946004214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946004215 S-adenosylmethionine binding site [chemical binding]; other site 909946004216 putative transporter; Provisional; Region: PRK11043 909946004217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946004218 putative substrate translocation pore; other site 909946004219 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 909946004220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946004221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 909946004222 dimerization interface [polypeptide binding]; other site 909946004223 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 909946004224 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946004225 DNA binding site [nucleotide binding] 909946004226 domain linker motif; other site 909946004227 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 909946004228 dimerization interface [polypeptide binding]; other site 909946004229 ligand binding site [chemical binding]; other site 909946004230 superoxide dismutase; Provisional; Region: PRK10543 909946004231 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 909946004232 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 909946004233 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 909946004234 NlpC/P60 family; Region: NLPC_P60; pfam00877 909946004235 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 909946004236 putative GSH binding site [chemical binding]; other site 909946004237 catalytic residues [active] 909946004238 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 909946004239 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 909946004240 dimer interface [polypeptide binding]; other site 909946004241 catalytic site [active] 909946004242 putative active site [active] 909946004243 putative substrate binding site [chemical binding]; other site 909946004244 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 909946004245 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 909946004246 dimer interface [polypeptide binding]; other site 909946004247 active site 909946004248 metal binding site [ion binding]; metal-binding site 909946004249 glutathione binding site [chemical binding]; other site 909946004250 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 909946004251 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 909946004252 FMN binding site [chemical binding]; other site 909946004253 active site 909946004254 substrate binding site [chemical binding]; other site 909946004255 catalytic residue [active] 909946004256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909946004257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946004258 Predicted Fe-S protein [General function prediction only]; Region: COG3313 909946004259 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909946004260 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909946004261 active site 909946004262 catalytic tetrad [active] 909946004263 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 909946004264 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 909946004265 E-class dimer interface [polypeptide binding]; other site 909946004266 P-class dimer interface [polypeptide binding]; other site 909946004267 active site 909946004268 Cu2+ binding site [ion binding]; other site 909946004269 Zn2+ binding site [ion binding]; other site 909946004270 Fusaric acid resistance protein family; Region: FUSC; pfam04632 909946004271 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 909946004272 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 909946004273 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 909946004274 HlyD family secretion protein; Region: HlyD_3; pfam13437 909946004275 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 909946004276 transcriptional regulator SlyA; Provisional; Region: PRK03573 909946004277 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 909946004278 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 909946004279 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 909946004280 lysozyme inhibitor; Provisional; Region: PRK11372 909946004281 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 909946004282 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 909946004283 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 909946004284 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 909946004285 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 909946004286 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 909946004287 active site 909946004288 HIGH motif; other site 909946004289 dimer interface [polypeptide binding]; other site 909946004290 KMSKS motif; other site 909946004291 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909946004292 RNA binding surface [nucleotide binding]; other site 909946004293 pyridoxamine kinase; Validated; Region: PRK05756 909946004294 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 909946004295 dimer interface [polypeptide binding]; other site 909946004296 pyridoxal binding site [chemical binding]; other site 909946004297 ATP binding site [chemical binding]; other site 909946004298 glutathionine S-transferase; Provisional; Region: PRK10542 909946004299 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 909946004300 C-terminal domain interface [polypeptide binding]; other site 909946004301 GSH binding site (G-site) [chemical binding]; other site 909946004302 dimer interface [polypeptide binding]; other site 909946004303 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 909946004304 dimer interface [polypeptide binding]; other site 909946004305 N-terminal domain interface [polypeptide binding]; other site 909946004306 substrate binding pocket (H-site) [chemical binding]; other site 909946004307 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 909946004308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946004309 putative substrate translocation pore; other site 909946004310 POT family; Region: PTR2; pfam00854 909946004311 endonuclease III; Provisional; Region: PRK10702 909946004312 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 909946004313 minor groove reading motif; other site 909946004314 helix-hairpin-helix signature motif; other site 909946004315 substrate binding pocket [chemical binding]; other site 909946004316 active site 909946004317 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 909946004318 electron transport complex RsxE subunit; Provisional; Region: PRK12405 909946004319 electron transport complex protein RnfG; Validated; Region: PRK01908 909946004320 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 909946004321 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 909946004322 SLBB domain; Region: SLBB; pfam10531 909946004323 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 909946004324 electron transport complex protein RnfB; Provisional; Region: PRK05113 909946004325 Putative Fe-S cluster; Region: FeS; cl17515 909946004326 4Fe-4S binding domain; Region: Fer4; pfam00037 909946004327 electron transport complex protein RsxA; Provisional; Region: PRK05151 909946004328 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 909946004329 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 909946004330 putative oxidoreductase; Provisional; Region: PRK11579 909946004331 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909946004332 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909946004333 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 909946004334 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 909946004335 active site 909946004336 purine riboside binding site [chemical binding]; other site 909946004337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 909946004338 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 909946004339 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 909946004340 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 909946004341 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 909946004342 fumarate hydratase; Provisional; Region: PRK15389 909946004343 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 909946004344 Fumarase C-terminus; Region: Fumerase_C; pfam05683 909946004345 fumarate hydratase; Reviewed; Region: fumC; PRK00485 909946004346 Class II fumarases; Region: Fumarase_classII; cd01362 909946004347 active site 909946004348 tetramer interface [polypeptide binding]; other site 909946004349 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 909946004350 sensor protein RstB; Provisional; Region: PRK10604 909946004351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946004352 dimerization interface [polypeptide binding]; other site 909946004353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946004354 dimer interface [polypeptide binding]; other site 909946004355 phosphorylation site [posttranslational modification] 909946004356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946004357 ATP binding site [chemical binding]; other site 909946004358 Mg2+ binding site [ion binding]; other site 909946004359 G-X-G motif; other site 909946004360 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 909946004361 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 909946004362 active site 909946004363 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 909946004364 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 909946004365 trimer interface [polypeptide binding]; other site 909946004366 eyelet of channel; other site 909946004367 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 909946004368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946004369 active site 909946004370 phosphorylation site [posttranslational modification] 909946004371 intermolecular recognition site; other site 909946004372 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946004373 DNA binding site [nucleotide binding] 909946004374 GlpM protein; Region: GlpM; pfam06942 909946004375 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 909946004376 Spore germination protein; Region: Spore_permease; cl17796 909946004377 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 909946004378 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 909946004379 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 909946004380 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 909946004381 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 909946004382 ligand binding site [chemical binding]; other site 909946004383 homodimer interface [polypeptide binding]; other site 909946004384 NAD(P) binding site [chemical binding]; other site 909946004385 trimer interface B [polypeptide binding]; other site 909946004386 trimer interface A [polypeptide binding]; other site 909946004387 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 909946004388 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 909946004389 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 909946004390 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 909946004391 Domain of unknown function DUF20; Region: UPF0118; pfam01594 909946004392 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 909946004393 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 909946004394 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 909946004395 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 909946004396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946004397 putative substrate translocation pore; other site 909946004398 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 909946004399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946004400 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 909946004401 dimerization interface [polypeptide binding]; other site 909946004402 substrate binding pocket [chemical binding]; other site 909946004403 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 909946004404 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 909946004405 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 909946004406 putative dithiobiotin synthetase; Provisional; Region: PRK12374 909946004407 AAA domain; Region: AAA_26; pfam13500 909946004408 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 909946004409 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 909946004410 Cl- selectivity filter; other site 909946004411 Cl- binding residues [ion binding]; other site 909946004412 pore gating glutamate residue; other site 909946004413 dimer interface [polypeptide binding]; other site 909946004414 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 909946004415 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 909946004416 Walker A/P-loop; other site 909946004417 ATP binding site [chemical binding]; other site 909946004418 Q-loop/lid; other site 909946004419 ABC transporter signature motif; other site 909946004420 Walker B; other site 909946004421 D-loop; other site 909946004422 H-loop/switch region; other site 909946004423 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 909946004424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946004425 dimer interface [polypeptide binding]; other site 909946004426 conserved gate region; other site 909946004427 ABC-ATPase subunit interface; other site 909946004428 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 909946004429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946004430 dimer interface [polypeptide binding]; other site 909946004431 conserved gate region; other site 909946004432 putative PBP binding loops; other site 909946004433 ABC-ATPase subunit interface; other site 909946004434 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 909946004435 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 909946004436 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 909946004437 4Fe-4S binding domain; Region: Fer4; pfam00037 909946004438 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 909946004439 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 909946004440 putative [Fe4-S4] binding site [ion binding]; other site 909946004441 putative molybdopterin cofactor binding site [chemical binding]; other site 909946004442 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 909946004443 putative molybdopterin cofactor binding site; other site 909946004444 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 909946004445 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 909946004446 putative [Fe4-S4] binding site [ion binding]; other site 909946004447 putative molybdopterin cofactor binding site [chemical binding]; other site 909946004448 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 909946004449 putative molybdopterin cofactor binding site; other site 909946004450 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 909946004451 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 909946004452 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 909946004453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946004454 Coenzyme A binding pocket [chemical binding]; other site 909946004455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 909946004456 hypothetical protein; Provisional; Region: PRK13659 909946004457 hypothetical protein; Provisional; Region: PRK02237 909946004458 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 909946004459 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 909946004460 putative active site pocket [active] 909946004461 putative metal binding site [ion binding]; other site 909946004462 putative oxidoreductase; Provisional; Region: PRK10083 909946004463 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 909946004464 putative NAD(P) binding site [chemical binding]; other site 909946004465 catalytic Zn binding site [ion binding]; other site 909946004466 structural Zn binding site [ion binding]; other site 909946004467 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 909946004468 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 909946004469 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 909946004470 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 909946004471 Transcriptional regulators [Transcription]; Region: GntR; COG1802 909946004472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946004473 DNA-binding site [nucleotide binding]; DNA binding site 909946004474 FCD domain; Region: FCD; pfam07729 909946004475 malonic semialdehyde reductase; Provisional; Region: PRK10538 909946004476 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 909946004477 putative NAD(P) binding site [chemical binding]; other site 909946004478 homodimer interface [polypeptide binding]; other site 909946004479 homotetramer interface [polypeptide binding]; other site 909946004480 active site 909946004481 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 909946004482 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 909946004483 active site 909946004484 Zn binding site [ion binding]; other site 909946004485 General stress protein [General function prediction only]; Region: GsiB; COG3729 909946004486 hypothetical protein; Validated; Region: PRK03657 909946004487 hypothetical protein; Provisional; Region: PRK10053 909946004488 putative transporter; Provisional; Region: PRK10054 909946004489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946004490 putative substrate translocation pore; other site 909946004491 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 909946004492 EamA-like transporter family; Region: EamA; pfam00892 909946004493 MarB protein; Region: MarB; pfam13999 909946004494 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 909946004495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946004496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946004497 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 909946004498 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 909946004499 inner membrane protein; Provisional; Region: PRK10995 909946004500 putative arabinose transporter; Provisional; Region: PRK03545 909946004501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946004502 putative substrate translocation pore; other site 909946004503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946004504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946004505 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 909946004506 putative dimerization interface [polypeptide binding]; other site 909946004507 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 909946004508 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 909946004509 NAD(P) binding site [chemical binding]; other site 909946004510 catalytic residues [active] 909946004511 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 909946004512 glutaminase; Provisional; Region: PRK00971 909946004513 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 909946004514 Predicted membrane protein [Function unknown]; Region: COG3781 909946004515 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 909946004516 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 909946004517 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 909946004518 trimer interface [polypeptide binding]; other site 909946004519 eyelet of channel; other site 909946004520 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 909946004521 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 909946004522 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 909946004523 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 909946004524 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 909946004525 Rubredoxin [Energy production and conversion]; Region: COG1773 909946004526 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 909946004527 iron binding site [ion binding]; other site 909946004528 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 909946004529 HupF/HypC family; Region: HupF_HypC; cl00394 909946004530 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 909946004531 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 909946004532 putative substrate-binding site; other site 909946004533 nickel binding site [ion binding]; other site 909946004534 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 909946004535 hydrogenase 1 large subunit; Provisional; Region: PRK10170 909946004536 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 909946004537 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 909946004538 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 909946004539 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 909946004540 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 909946004541 active site 909946004542 Transcriptional regulators [Transcription]; Region: FadR; COG2186 909946004543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946004544 DNA-binding site [nucleotide binding]; DNA binding site 909946004545 FCD domain; Region: FCD; pfam07729 909946004546 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 909946004547 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 909946004548 putative NAD(P) binding site [chemical binding]; other site 909946004549 catalytic Zn binding site [ion binding]; other site 909946004550 structural Zn binding site [ion binding]; other site 909946004551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946004552 D-galactonate transporter; Region: 2A0114; TIGR00893 909946004553 putative substrate translocation pore; other site 909946004554 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 909946004555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946004556 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909946004557 putative substrate translocation pore; other site 909946004558 hypothetical protein; Provisional; Region: PRK06184 909946004559 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 909946004560 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 909946004561 Transcriptional regulators [Transcription]; Region: MarR; COG1846 909946004562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909946004563 putative DNA binding site [nucleotide binding]; other site 909946004564 putative Zn2+ binding site [ion binding]; other site 909946004565 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 909946004566 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 909946004567 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 909946004568 homotrimer interaction site [polypeptide binding]; other site 909946004569 putative active site [active] 909946004570 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 909946004571 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 909946004572 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 909946004573 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909946004574 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946004575 DNA binding site [nucleotide binding] 909946004576 domain linker motif; other site 909946004577 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 909946004578 dimerization interface (closed form) [polypeptide binding]; other site 909946004579 ligand binding site [chemical binding]; other site 909946004580 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 909946004581 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 909946004582 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909946004583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946004584 homodimer interface [polypeptide binding]; other site 909946004585 catalytic residue [active] 909946004586 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 909946004587 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 909946004588 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 909946004589 active site 909946004590 catalytic site [active] 909946004591 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 909946004592 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 909946004593 active site 909946004594 catalytic site [active] 909946004595 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 909946004596 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 909946004597 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 909946004598 catalytic site [active] 909946004599 active site 909946004600 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 909946004601 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 909946004602 acid-resistance protein; Provisional; Region: hdeB; PRK11566 909946004603 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 909946004604 biofilm-dependent modulation protein; Provisional; Region: PRK11436 909946004605 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 909946004606 malate dehydrogenase; Provisional; Region: PRK13529 909946004607 Malic enzyme, N-terminal domain; Region: malic; pfam00390 909946004608 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 909946004609 NAD(P) binding site [chemical binding]; other site 909946004610 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 909946004611 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 909946004612 NAD binding site [chemical binding]; other site 909946004613 substrate binding site [chemical binding]; other site 909946004614 catalytic Zn binding site [ion binding]; other site 909946004615 tetramer interface [polypeptide binding]; other site 909946004616 structural Zn binding site [ion binding]; other site 909946004617 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 909946004618 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 909946004619 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 909946004620 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 909946004621 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 909946004622 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 909946004623 [4Fe-4S] binding site [ion binding]; other site 909946004624 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 909946004625 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 909946004626 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 909946004627 molybdopterin cofactor binding site; other site 909946004628 aromatic amino acid exporter; Provisional; Region: PRK11689 909946004629 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 909946004630 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 909946004631 trimer interface [polypeptide binding]; other site 909946004632 eyelet of channel; other site 909946004633 Uncharacterized conserved protein [Function unknown]; Region: COG3791 909946004634 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 909946004635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946004636 putative substrate translocation pore; other site 909946004637 TetR family transcriptional regulator; Provisional; Region: PRK14996 909946004638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946004639 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 909946004640 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 909946004641 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 909946004642 [4Fe-4S] binding site [ion binding]; other site 909946004643 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 909946004644 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 909946004645 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 909946004646 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 909946004647 molybdopterin cofactor binding site; other site 909946004648 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 909946004649 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 909946004650 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 909946004651 hypothetical protein; Provisional; Region: PRK10281 909946004652 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 909946004653 L-asparagine permease; Provisional; Region: PRK15049 909946004654 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 909946004655 Uncharacterized conserved protein [Function unknown]; Region: COG3391 909946004656 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 909946004657 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 909946004658 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 909946004659 N-terminal plug; other site 909946004660 ligand-binding site [chemical binding]; other site 909946004661 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 909946004662 DNA-binding site [nucleotide binding]; DNA binding site 909946004663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 909946004664 FCD domain; Region: FCD; pfam07729 909946004665 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 909946004666 Prostaglandin dehydrogenases; Region: PGDH; cd05288 909946004667 NAD(P) binding site [chemical binding]; other site 909946004668 substrate binding site [chemical binding]; other site 909946004669 dimer interface [polypeptide binding]; other site 909946004670 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 909946004671 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 909946004672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 909946004673 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 909946004674 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 909946004675 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 909946004676 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 909946004677 1-pyrroline dehydrogenase; Region: ABALDH; TIGR03374 909946004678 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 909946004679 tetrameric interface [polypeptide binding]; other site 909946004680 NAD binding site [chemical binding]; other site 909946004681 catalytic residues [active] 909946004682 substrate binding site [chemical binding]; other site 909946004683 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 909946004684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946004685 DNA-binding site [nucleotide binding]; DNA binding site 909946004686 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909946004687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946004688 homodimer interface [polypeptide binding]; other site 909946004689 catalytic residue [active] 909946004690 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 909946004691 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 909946004692 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 909946004693 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 909946004694 Peptidase family U32; Region: Peptidase_U32; pfam01136 909946004695 Collagenase; Region: DUF3656; pfam12392 909946004696 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 909946004697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946004698 non-specific DNA binding site [nucleotide binding]; other site 909946004699 salt bridge; other site 909946004700 sequence-specific DNA binding site [nucleotide binding]; other site 909946004701 Cupin domain; Region: Cupin_2; pfam07883 909946004702 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 909946004703 benzoate transporter; Region: benE; TIGR00843 909946004704 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 909946004705 tellurite resistance protein TehB; Provisional; Region: PRK11207 909946004706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946004707 S-adenosylmethionine binding site [chemical binding]; other site 909946004708 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 909946004709 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 909946004710 gating phenylalanine in ion channel; other site 909946004711 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 909946004712 putative trimer interface [polypeptide binding]; other site 909946004713 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 909946004714 putative trimer interface [polypeptide binding]; other site 909946004715 putative CoA binding site [chemical binding]; other site 909946004716 putative CoA binding site [chemical binding]; other site 909946004717 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 909946004718 putative trimer interface [polypeptide binding]; other site 909946004719 putative CoA binding site [chemical binding]; other site 909946004720 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 909946004721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946004722 Coenzyme A binding pocket [chemical binding]; other site 909946004723 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 909946004724 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 909946004725 oligomer interface [polypeptide binding]; other site 909946004726 active site 909946004727 metal binding site [ion binding]; metal-binding site 909946004728 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 909946004729 active site 909946004730 P-loop; other site 909946004731 phosphorylation site [posttranslational modification] 909946004732 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 909946004733 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 909946004734 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 909946004735 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909946004736 active site 909946004737 phosphorylation site [posttranslational modification] 909946004738 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 909946004739 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 909946004740 substrate binding site [chemical binding]; other site 909946004741 hexamer interface [polypeptide binding]; other site 909946004742 metal binding site [ion binding]; metal-binding site 909946004743 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909946004744 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 909946004745 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946004746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 909946004747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946004748 Coenzyme A binding pocket [chemical binding]; other site 909946004749 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 909946004750 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 909946004751 teramer interface [polypeptide binding]; other site 909946004752 active site 909946004753 FMN binding site [chemical binding]; other site 909946004754 catalytic residues [active] 909946004755 Uncharacterized conserved protein [Function unknown]; Region: COG2353 909946004756 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 909946004757 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 909946004758 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 909946004759 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 909946004760 substrate binding pocket [chemical binding]; other site 909946004761 catalytic triad [active] 909946004762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 909946004763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 909946004764 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 909946004765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946004766 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 909946004767 dimerization interface [polypeptide binding]; other site 909946004768 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 909946004769 dimer interface [polypeptide binding]; other site 909946004770 ligand binding site [chemical binding]; other site 909946004771 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 909946004772 HAMP domain; Region: HAMP; pfam00672 909946004773 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 909946004774 dimer interface [polypeptide binding]; other site 909946004775 putative CheW interface [polypeptide binding]; other site 909946004776 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 909946004777 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 909946004778 substrate binding site [chemical binding]; other site 909946004779 catalytic Zn binding site [ion binding]; other site 909946004780 NAD binding site [chemical binding]; other site 909946004781 structural Zn binding site [ion binding]; other site 909946004782 dimer interface [polypeptide binding]; other site 909946004783 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 909946004784 putative metal binding site [ion binding]; other site 909946004785 putative homodimer interface [polypeptide binding]; other site 909946004786 putative homotetramer interface [polypeptide binding]; other site 909946004787 putative homodimer-homodimer interface [polypeptide binding]; other site 909946004788 putative allosteric switch controlling residues; other site 909946004789 Sif protein; Region: Sif; cl11505 909946004790 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 909946004791 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 909946004792 active site 909946004793 catalytic triad [active] 909946004794 oxyanion hole [active] 909946004795 Predicted membrane protein [Function unknown]; Region: COG3326 909946004796 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946004797 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 909946004798 substrate binding pocket [chemical binding]; other site 909946004799 membrane-bound complex binding site; other site 909946004800 hinge residues; other site 909946004801 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 909946004802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946004803 dimer interface [polypeptide binding]; other site 909946004804 conserved gate region; other site 909946004805 putative PBP binding loops; other site 909946004806 ABC-ATPase subunit interface; other site 909946004807 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 909946004808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946004809 Walker A/P-loop; other site 909946004810 ATP binding site [chemical binding]; other site 909946004811 Q-loop/lid; other site 909946004812 ABC transporter signature motif; other site 909946004813 Walker B; other site 909946004814 D-loop; other site 909946004815 H-loop/switch region; other site 909946004816 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 909946004817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946004818 dimer interface [polypeptide binding]; other site 909946004819 conserved gate region; other site 909946004820 putative PBP binding loops; other site 909946004821 ABC-ATPase subunit interface; other site 909946004822 Predicted membrane protein [Function unknown]; Region: COG5305 909946004823 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 909946004824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946004825 S-adenosylmethionine binding site [chemical binding]; other site 909946004826 cytochrome b561; Provisional; Region: PRK11513 909946004827 Uncharacterized conserved protein [Function unknown]; Region: COG1434 909946004828 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 909946004829 putative active site [active] 909946004830 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 909946004831 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909946004832 ATP binding site [chemical binding]; other site 909946004833 putative Mg++ binding site [ion binding]; other site 909946004834 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946004835 nucleotide binding region [chemical binding]; other site 909946004836 ATP-binding site [chemical binding]; other site 909946004837 Helicase associated domain (HA2); Region: HA2; pfam04408 909946004838 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 909946004839 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 909946004840 azoreductase; Reviewed; Region: PRK00170 909946004841 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 909946004842 Uncharacterized conserved protein [Function unknown]; Region: COG3791 909946004843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 909946004844 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 909946004845 hypothetical protein; Provisional; Region: PRK10695 909946004846 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 909946004847 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 909946004848 putative ligand binding site [chemical binding]; other site 909946004849 putative NAD binding site [chemical binding]; other site 909946004850 catalytic site [active] 909946004851 heat-inducible protein; Provisional; Region: PRK10449 909946004852 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 909946004853 Domain of unknown function (DUF333); Region: DUF333; pfam03891 909946004854 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 909946004855 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 909946004856 dimer interface [polypeptide binding]; other site 909946004857 PYR/PP interface [polypeptide binding]; other site 909946004858 TPP binding site [chemical binding]; other site 909946004859 substrate binding site [chemical binding]; other site 909946004860 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 909946004861 Domain of unknown function; Region: EKR; smart00890 909946004862 4Fe-4S binding domain; Region: Fer4_6; pfam12837 909946004863 4Fe-4S binding domain; Region: Fer4; pfam00037 909946004864 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 909946004865 TPP-binding site [chemical binding]; other site 909946004866 dimer interface [polypeptide binding]; other site 909946004867 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 909946004868 Ligand Binding Site [chemical binding]; other site 909946004869 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 909946004870 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 909946004871 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 909946004872 Ligand Binding Site [chemical binding]; other site 909946004873 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 909946004874 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 909946004875 ATP binding site [chemical binding]; other site 909946004876 Mg++ binding site [ion binding]; other site 909946004877 motif III; other site 909946004878 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946004879 nucleotide binding region [chemical binding]; other site 909946004880 ATP-binding site [chemical binding]; other site 909946004881 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 909946004882 putative RNA binding site [nucleotide binding]; other site 909946004883 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 909946004884 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 909946004885 Cl binding site [ion binding]; other site 909946004886 oligomer interface [polypeptide binding]; other site 909946004887 HAMP domain; Region: HAMP; pfam00672 909946004888 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 909946004889 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 909946004890 dimer interface [polypeptide binding]; other site 909946004891 putative CheW interface [polypeptide binding]; other site 909946004892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 909946004893 Smr domain; Region: Smr; pfam01713 909946004894 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 909946004895 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 909946004896 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 909946004897 DNA binding site [nucleotide binding] 909946004898 active site 909946004899 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 909946004900 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 909946004901 ligand binding site [chemical binding]; other site 909946004902 flexible hinge region; other site 909946004903 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 909946004904 putative switch regulator; other site 909946004905 non-specific DNA interactions [nucleotide binding]; other site 909946004906 DNA binding site [nucleotide binding] 909946004907 sequence specific DNA binding site [nucleotide binding]; other site 909946004908 putative cAMP binding site [chemical binding]; other site 909946004909 universal stress protein UspE; Provisional; Region: PRK11175 909946004910 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 909946004911 Ligand Binding Site [chemical binding]; other site 909946004912 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 909946004913 Ligand Binding Site [chemical binding]; other site 909946004914 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 909946004915 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 909946004916 Mechanosensitive ion channel; Region: MS_channel; pfam00924 909946004917 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 909946004918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946004919 non-specific DNA binding site [nucleotide binding]; other site 909946004920 salt bridge; other site 909946004921 sequence-specific DNA binding site [nucleotide binding]; other site 909946004922 Cupin domain; Region: Cupin_2; pfam07883 909946004923 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 909946004924 B3/4 domain; Region: B3_4; pfam03483 909946004925 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077 909946004926 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 909946004927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946004928 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 909946004929 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 909946004930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909946004931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946004932 oxidoreductase; Provisional; Region: PRK12742 909946004933 classical (c) SDRs; Region: SDR_c; cd05233 909946004934 NAD(P) binding site [chemical binding]; other site 909946004935 active site 909946004936 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909946004937 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909946004938 active site 909946004939 catalytic tetrad [active] 909946004940 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946004941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946004942 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 909946004943 putative effector binding pocket; other site 909946004944 putative dimerization interface [polypeptide binding]; other site 909946004945 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 909946004946 NmrA-like family; Region: NmrA; pfam05368 909946004947 NAD(P) binding site [chemical binding]; other site 909946004948 active site lysine 909946004949 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 909946004950 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 909946004951 peptide binding site [polypeptide binding]; other site 909946004952 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 909946004953 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 909946004954 putative active site [active] 909946004955 Zn binding site [ion binding]; other site 909946004956 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 909946004957 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 909946004958 active site 909946004959 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 909946004960 dimer interface [polypeptide binding]; other site 909946004961 catalytic triad [active] 909946004962 peroxidatic and resolving cysteines [active] 909946004963 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 909946004964 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 909946004965 putative aromatic amino acid binding site; other site 909946004966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946004967 Walker A motif; other site 909946004968 ATP binding site [chemical binding]; other site 909946004969 Walker B motif; other site 909946004970 arginine finger; other site 909946004971 hypothetical protein; Provisional; Region: PRK05415 909946004972 TIGR01620 family protein; Region: hyp_HI0043 909946004973 Predicted ATPase [General function prediction only]; Region: COG3106 909946004974 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 909946004975 active site residue [active] 909946004976 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 909946004977 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 909946004978 phage shock protein C; Region: phageshock_pspC; TIGR02978 909946004979 phage shock protein B; Provisional; Region: pspB; PRK09458 909946004980 phage shock protein PspA; Provisional; Region: PRK10698 909946004981 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 909946004982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946004983 Walker A motif; other site 909946004984 ATP binding site [chemical binding]; other site 909946004985 Walker B motif; other site 909946004986 arginine finger; other site 909946004987 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 909946004988 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 909946004989 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 909946004990 peptide binding site [polypeptide binding]; other site 909946004991 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 909946004992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946004993 dimer interface [polypeptide binding]; other site 909946004994 conserved gate region; other site 909946004995 putative PBP binding loops; other site 909946004996 ABC-ATPase subunit interface; other site 909946004997 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 909946004998 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 909946004999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946005000 dimer interface [polypeptide binding]; other site 909946005001 conserved gate region; other site 909946005002 putative PBP binding loops; other site 909946005003 ABC-ATPase subunit interface; other site 909946005004 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 909946005005 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909946005006 Walker A/P-loop; other site 909946005007 ATP binding site [chemical binding]; other site 909946005008 Q-loop/lid; other site 909946005009 ABC transporter signature motif; other site 909946005010 Walker B; other site 909946005011 D-loop; other site 909946005012 H-loop/switch region; other site 909946005013 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 909946005014 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 909946005015 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909946005016 Walker A/P-loop; other site 909946005017 ATP binding site [chemical binding]; other site 909946005018 Q-loop/lid; other site 909946005019 ABC transporter signature motif; other site 909946005020 Walker B; other site 909946005021 D-loop; other site 909946005022 H-loop/switch region; other site 909946005023 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 909946005024 Protein kinase domain; Region: Pkinase; pfam00069 909946005025 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 909946005026 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 909946005027 NAD binding site [chemical binding]; other site 909946005028 homotetramer interface [polypeptide binding]; other site 909946005029 homodimer interface [polypeptide binding]; other site 909946005030 substrate binding site [chemical binding]; other site 909946005031 active site 909946005032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 909946005033 Uncharacterized conserved protein [Function unknown]; Region: COG2128 909946005034 exoribonuclease II; Provisional; Region: PRK05054 909946005035 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 909946005036 RNB domain; Region: RNB; pfam00773 909946005037 S1 RNA binding domain; Region: S1; pfam00575 909946005038 RNase II stability modulator; Provisional; Region: PRK10060 909946005039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 909946005040 putative active site [active] 909946005041 heme pocket [chemical binding]; other site 909946005042 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 909946005043 metal binding site [ion binding]; metal-binding site 909946005044 active site 909946005045 I-site; other site 909946005046 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946005047 hypothetical protein; Provisional; Region: PRK13658 909946005048 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909946005049 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 909946005050 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946005051 lipoprotein; Provisional; Region: PRK10540 909946005052 translation initiation factor Sui1; Validated; Region: PRK06824 909946005053 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 909946005054 putative rRNA binding site [nucleotide binding]; other site 909946005055 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 909946005056 active site 909946005057 dimer interface [polypeptide binding]; other site 909946005058 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 909946005059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 909946005060 binding surface 909946005061 TPR motif; other site 909946005062 Predicted membrane protein [Function unknown]; Region: COG3771 909946005063 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 909946005064 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 909946005065 active site 909946005066 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 909946005067 dimerization interface [polypeptide binding]; other site 909946005068 active site 909946005069 aconitate hydratase; Validated; Region: PRK09277 909946005070 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 909946005071 substrate binding site [chemical binding]; other site 909946005072 ligand binding site [chemical binding]; other site 909946005073 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 909946005074 substrate binding site [chemical binding]; other site 909946005075 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 909946005076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946005077 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 909946005078 substrate binding site [chemical binding]; other site 909946005079 putative dimerization interface [polypeptide binding]; other site 909946005080 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 909946005081 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 909946005082 active site 909946005083 interdomain interaction site; other site 909946005084 putative metal-binding site [ion binding]; other site 909946005085 nucleotide binding site [chemical binding]; other site 909946005086 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 909946005087 domain I; other site 909946005088 DNA binding groove [nucleotide binding] 909946005089 phosphate binding site [ion binding]; other site 909946005090 domain II; other site 909946005091 domain III; other site 909946005092 nucleotide binding site [chemical binding]; other site 909946005093 catalytic site [active] 909946005094 domain IV; other site 909946005095 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 909946005096 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 909946005097 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 909946005098 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 909946005099 hypothetical protein; Provisional; Region: PRK11037 909946005100 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 909946005101 putative inner membrane peptidase; Provisional; Region: PRK11778 909946005102 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 909946005103 tandem repeat interface [polypeptide binding]; other site 909946005104 oligomer interface [polypeptide binding]; other site 909946005105 active site residues [active] 909946005106 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 909946005107 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 909946005108 NADP binding site [chemical binding]; other site 909946005109 homodimer interface [polypeptide binding]; other site 909946005110 active site 909946005111 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 909946005112 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 909946005113 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 909946005114 homodimer interface [polypeptide binding]; other site 909946005115 Walker A motif; other site 909946005116 ATP binding site [chemical binding]; other site 909946005117 hydroxycobalamin binding site [chemical binding]; other site 909946005118 Walker B motif; other site 909946005119 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 909946005120 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909946005121 RNA binding surface [nucleotide binding]; other site 909946005122 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 909946005123 probable active site [active] 909946005124 hypothetical protein; Provisional; Region: PRK11630 909946005125 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 909946005126 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 909946005127 active site 909946005128 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 909946005129 anthranilate synthase component I; Provisional; Region: PRK13564 909946005130 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 909946005131 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 909946005132 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 909946005133 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 909946005134 glutamine binding [chemical binding]; other site 909946005135 catalytic triad [active] 909946005136 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 909946005137 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 909946005138 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 909946005139 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 909946005140 active site 909946005141 ribulose/triose binding site [chemical binding]; other site 909946005142 phosphate binding site [ion binding]; other site 909946005143 substrate (anthranilate) binding pocket [chemical binding]; other site 909946005144 product (indole) binding pocket [chemical binding]; other site 909946005145 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 909946005146 active site 909946005147 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 909946005148 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 909946005149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946005150 catalytic residue [active] 909946005151 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 909946005152 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 909946005153 substrate binding site [chemical binding]; other site 909946005154 active site 909946005155 catalytic residues [active] 909946005156 heterodimer interface [polypeptide binding]; other site 909946005157 General stress protein [General function prediction only]; Region: GsiB; COG3729 909946005158 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 909946005159 dimerization interface [polypeptide binding]; other site 909946005160 metal binding site [ion binding]; metal-binding site 909946005161 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 909946005162 dinuclear metal binding motif [ion binding]; other site 909946005163 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 909946005164 dimanganese center [ion binding]; other site 909946005165 outer membrane protein W; Provisional; Region: PRK10959 909946005166 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 909946005167 hypothetical protein; Provisional; Region: PRK02868 909946005168 intracellular septation protein A; Reviewed; Region: PRK00259 909946005169 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 909946005170 transport protein TonB; Provisional; Region: PRK10819 909946005171 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 909946005172 YciI-like protein; Reviewed; Region: PRK11370 909946005173 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 909946005174 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 909946005175 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 909946005176 putative active site [active] 909946005177 catalytic site [active] 909946005178 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 909946005179 putative active site [active] 909946005180 catalytic site [active] 909946005181 dsDNA-mimic protein; Reviewed; Region: PRK05094 909946005182 Ion transport protein; Region: Ion_trans; pfam00520 909946005183 Ion channel; Region: Ion_trans_2; pfam07885 909946005184 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 909946005185 Double zinc ribbon; Region: DZR; pfam12773 909946005186 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 909946005187 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909946005188 Walker A/P-loop; other site 909946005189 ATP binding site [chemical binding]; other site 909946005190 Q-loop/lid; other site 909946005191 ABC transporter signature motif; other site 909946005192 Walker B; other site 909946005193 D-loop; other site 909946005194 H-loop/switch region; other site 909946005195 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 909946005196 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 909946005197 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909946005198 Walker A/P-loop; other site 909946005199 ATP binding site [chemical binding]; other site 909946005200 Q-loop/lid; other site 909946005201 ABC transporter signature motif; other site 909946005202 Walker B; other site 909946005203 D-loop; other site 909946005204 H-loop/switch region; other site 909946005205 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 909946005206 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 909946005207 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 909946005208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946005209 dimer interface [polypeptide binding]; other site 909946005210 conserved gate region; other site 909946005211 ABC-ATPase subunit interface; other site 909946005212 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 909946005213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946005214 dimer interface [polypeptide binding]; other site 909946005215 conserved gate region; other site 909946005216 putative PBP binding loops; other site 909946005217 ABC-ATPase subunit interface; other site 909946005218 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 909946005219 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 909946005220 peptide binding site [polypeptide binding]; other site 909946005221 hypothetical protein; Provisional; Region: PRK11111 909946005222 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 909946005223 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 909946005224 putative catalytic cysteine [active] 909946005225 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 909946005226 putative active site [active] 909946005227 metal binding site [ion binding]; metal-binding site 909946005228 thymidine kinase; Provisional; Region: PRK04296 909946005229 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 909946005230 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 909946005231 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 909946005232 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 909946005233 active site 909946005234 tetramer interface; other site 909946005235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946005236 active site 909946005237 response regulator of RpoS; Provisional; Region: PRK10693 909946005238 phosphorylation site [posttranslational modification] 909946005239 intermolecular recognition site; other site 909946005240 dimerization interface [polypeptide binding]; other site 909946005241 hypothetical protein; Provisional; Region: PRK10279 909946005242 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 909946005243 active site 909946005244 nucleophile elbow; other site 909946005245 SEC-C motif; Region: SEC-C; pfam02810 909946005246 hypothetical protein; Provisional; Region: PRK04233 909946005247 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 909946005248 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 909946005249 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 909946005250 putative active site [active] 909946005251 putative substrate binding site [chemical binding]; other site 909946005252 putative cosubstrate binding site; other site 909946005253 catalytic site [active] 909946005254 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 909946005255 Sel1-like repeats; Region: SEL1; smart00671 909946005256 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 909946005257 Sel1-like repeats; Region: SEL1; smart00671 909946005258 Sel1-like repeats; Region: SEL1; smart00671 909946005259 Sel1-like repeats; Region: SEL1; smart00671 909946005260 Sel1-like repeats; Region: SEL1; smart00671 909946005261 Sel1-like repeats; Region: SEL1; smart00671 909946005262 Sel1-like repeats; Region: SEL1; smart00671 909946005263 Sel1-like repeats; Region: SEL1; smart00671 909946005264 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 909946005265 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 909946005266 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 909946005267 4Fe-4S binding domain; Region: Fer4; cl02805 909946005268 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 909946005269 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 909946005270 [4Fe-4S] binding site [ion binding]; other site 909946005271 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 909946005272 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 909946005273 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 909946005274 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 909946005275 molybdopterin cofactor binding site; other site 909946005276 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 909946005277 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 909946005278 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 909946005279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946005280 dimerization interface [polypeptide binding]; other site 909946005281 Histidine kinase; Region: HisKA_3; pfam07730 909946005282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946005283 ATP binding site [chemical binding]; other site 909946005284 Mg2+ binding site [ion binding]; other site 909946005285 G-X-G motif; other site 909946005286 transcriptional regulator NarL; Provisional; Region: PRK10651 909946005287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946005288 active site 909946005289 phosphorylation site [posttranslational modification] 909946005290 intermolecular recognition site; other site 909946005291 dimerization interface [polypeptide binding]; other site 909946005292 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946005293 DNA binding residues [nucleotide binding] 909946005294 dimerization interface [polypeptide binding]; other site 909946005295 putative invasin; Provisional; Region: PRK10177 909946005296 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 909946005297 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 909946005298 cation transport regulator; Reviewed; Region: chaB; PRK09582 909946005299 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 909946005300 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 909946005301 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 909946005302 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 909946005303 hypothetical protein; Provisional; Region: PRK10941 909946005304 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 909946005305 hypothetical protein; Provisional; Region: PRK10278 909946005306 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 909946005307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946005308 peptide chain release factor 1; Validated; Region: prfA; PRK00591 909946005309 This domain is found in peptide chain release factors; Region: PCRF; smart00937 909946005310 RF-1 domain; Region: RF-1; pfam00472 909946005311 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 909946005312 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 909946005313 tRNA; other site 909946005314 putative tRNA binding site [nucleotide binding]; other site 909946005315 putative NADP binding site [chemical binding]; other site 909946005316 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 909946005317 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 909946005318 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 909946005319 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 909946005320 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 909946005321 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 909946005322 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 909946005323 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909946005324 active site 909946005325 putative transporter; Provisional; Region: PRK11660 909946005326 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 909946005327 Sulfate transporter family; Region: Sulfate_transp; pfam00916 909946005328 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 909946005329 hypothetical protein; Provisional; Region: PRK10692 909946005330 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 909946005331 putative active site [active] 909946005332 catalytic residue [active] 909946005333 GTP-binding protein YchF; Reviewed; Region: PRK09601 909946005334 YchF GTPase; Region: YchF; cd01900 909946005335 G1 box; other site 909946005336 GTP/Mg2+ binding site [chemical binding]; other site 909946005337 Switch I region; other site 909946005338 G2 box; other site 909946005339 Switch II region; other site 909946005340 G3 box; other site 909946005341 G4 box; other site 909946005342 G5 box; other site 909946005343 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 909946005344 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 909946005345 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 909946005346 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 909946005347 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 909946005348 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 909946005349 hydrogenase 1 large subunit; Provisional; Region: PRK10170 909946005350 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 909946005351 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 909946005352 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 909946005353 putative substrate-binding site; other site 909946005354 nickel binding site [ion binding]; other site 909946005355 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 909946005356 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 909946005357 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 909946005358 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 909946005359 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 909946005360 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 909946005361 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 909946005362 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 909946005363 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 909946005364 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 909946005365 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 909946005366 NAD(P) binding site [chemical binding]; other site 909946005367 trehalase; Provisional; Region: treA; PRK13271 909946005368 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 909946005369 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 909946005370 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 909946005371 Flagellar regulator YcgR; Region: YcgR; pfam07317 909946005372 PilZ domain; Region: PilZ; pfam07238 909946005373 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 909946005374 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 909946005375 N-acetyl-D-glucosamine binding site [chemical binding]; other site 909946005376 catalytic residue [active] 909946005377 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 909946005378 dimer interface [polypeptide binding]; other site 909946005379 catalytic triad [active] 909946005380 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 909946005381 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 909946005382 TrkA-C domain; Region: TrkA_C; pfam02080 909946005383 Transporter associated domain; Region: CorC_HlyC; smart01091 909946005384 alanine racemase; Reviewed; Region: dadX; PRK03646 909946005385 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 909946005386 active site 909946005387 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 909946005388 substrate binding site [chemical binding]; other site 909946005389 catalytic residues [active] 909946005390 dimer interface [polypeptide binding]; other site 909946005391 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 909946005392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 909946005393 SpoVR family protein; Provisional; Region: PRK11767 909946005394 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 909946005395 fatty acid metabolism regulator; Provisional; Region: PRK04984 909946005396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946005397 DNA-binding site [nucleotide binding]; DNA binding site 909946005398 FadR C-terminal domain; Region: FadR_C; pfam07840 909946005399 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 909946005400 transmembrane helices; other site 909946005401 disulfide bond formation protein B; Provisional; Region: PRK01749 909946005402 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 909946005403 GnsA/GnsB family; Region: GnsAB; pfam08178 909946005404 hypothetical protein; Provisional; Region: PRK05170 909946005405 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 909946005406 hypothetical protein; Provisional; Region: PRK10691 909946005407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 909946005408 septum formation inhibitor; Reviewed; Region: minC; PRK03511 909946005409 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 909946005410 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 909946005411 cell division inhibitor MinD; Provisional; Region: PRK10818 909946005412 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 909946005413 Switch I; other site 909946005414 Switch II; other site 909946005415 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 909946005416 ribonuclease D; Provisional; Region: PRK10829 909946005417 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 909946005418 catalytic site [active] 909946005419 putative active site [active] 909946005420 putative substrate binding site [chemical binding]; other site 909946005421 HRDC domain; Region: HRDC; cl02578 909946005422 Transposase IS200 like; Region: Y1_Tnp; pfam01797 909946005423 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 909946005424 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 909946005425 acyl-activating enzyme (AAE) consensus motif; other site 909946005426 putative AMP binding site [chemical binding]; other site 909946005427 putative active site [active] 909946005428 putative CoA binding site [chemical binding]; other site 909946005429 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 909946005430 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 909946005431 Glycoprotease family; Region: Peptidase_M22; pfam00814 909946005432 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 909946005433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 909946005434 DEAD_2; Region: DEAD_2; pfam06733 909946005435 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 909946005436 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 909946005437 homotrimer interaction site [polypeptide binding]; other site 909946005438 putative active site [active] 909946005439 hypothetical protein; Provisional; Region: PRK05114 909946005440 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 909946005441 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 909946005442 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 909946005443 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 909946005444 putative active site [active] 909946005445 putative CoA binding site [chemical binding]; other site 909946005446 nudix motif; other site 909946005447 metal binding site [ion binding]; metal-binding site 909946005448 L-serine deaminase; Provisional; Region: PRK15023 909946005449 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 909946005450 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 909946005451 phage resistance protein; Provisional; Region: PRK10551 909946005452 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 909946005453 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946005454 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 909946005455 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 909946005456 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 909946005457 Transporter associated domain; Region: CorC_HlyC; smart01091 909946005458 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 909946005459 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 909946005460 active pocket/dimerization site; other site 909946005461 active site 909946005462 phosphorylation site [posttranslational modification] 909946005463 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 909946005464 active site 909946005465 phosphorylation site [posttranslational modification] 909946005466 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 909946005467 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 909946005468 hypothetical protein; Provisional; Region: PRK02913 909946005469 hypothetical protein; Provisional; Region: PRK11469 909946005470 Domain of unknown function DUF; Region: DUF204; pfam02659 909946005471 Domain of unknown function DUF; Region: DUF204; pfam02659 909946005472 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 909946005473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946005474 S-adenosylmethionine binding site [chemical binding]; other site 909946005475 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 909946005476 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 909946005477 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 909946005478 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 909946005479 DNA-binding site [nucleotide binding]; DNA binding site 909946005480 RNA-binding motif; other site 909946005481 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 909946005482 YebO-like protein; Region: YebO; pfam13974 909946005483 PhoPQ regulatory protein; Provisional; Region: PRK10299 909946005484 YobH-like protein; Region: YobH; pfam13996 909946005485 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 909946005486 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909946005487 dimerization interface [polypeptide binding]; other site 909946005488 putative Zn2+ binding site [ion binding]; other site 909946005489 putative DNA binding site [nucleotide binding]; other site 909946005490 Bacterial transcriptional regulator; Region: IclR; pfam01614 909946005491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946005492 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909946005493 putative substrate translocation pore; other site 909946005494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946005495 heat shock protein HtpX; Provisional; Region: PRK05457 909946005496 carboxy-terminal protease; Provisional; Region: PRK11186 909946005497 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 909946005498 protein binding site [polypeptide binding]; other site 909946005499 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 909946005500 Catalytic dyad [active] 909946005501 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 909946005502 ProP expression regulator; Provisional; Region: PRK04950 909946005503 ProQ/FINO family; Region: ProQ; pfam04352 909946005504 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 909946005505 GAF domain; Region: GAF_2; pfam13185 909946005506 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 909946005507 Paraquat-inducible protein A; Region: PqiA; pfam04403 909946005508 Paraquat-inducible protein A; Region: PqiA; pfam04403 909946005509 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 909946005510 mce related protein; Region: MCE; pfam02470 909946005511 mce related protein; Region: MCE; pfam02470 909946005512 mce related protein; Region: MCE; pfam02470 909946005513 mce related protein; Region: MCE; pfam02470 909946005514 mce related protein; Region: MCE; pfam02470 909946005515 mce related protein; Region: MCE; pfam02470 909946005516 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 909946005517 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 909946005518 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 909946005519 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 909946005520 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 909946005521 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 909946005522 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 909946005523 type III secretion protein SopE2; Provisional; Region: PRK15280 909946005524 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 909946005525 SopE GEF domain; Region: SopE_GEF; pfam07487 909946005526 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 909946005527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946005528 Coenzyme A binding pocket [chemical binding]; other site 909946005529 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 909946005530 DNA binding site [nucleotide binding] 909946005531 active site 909946005532 Int/Topo IB signature motif; other site 909946005533 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 909946005534 EamA-like transporter family; Region: EamA; pfam00892 909946005535 EamA-like transporter family; Region: EamA; pfam00892 909946005536 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 909946005537 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 909946005538 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 909946005539 ADP-ribose binding site [chemical binding]; other site 909946005540 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 909946005541 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 909946005542 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 909946005543 Predicted chitinase [General function prediction only]; Region: COG3179 909946005544 exonuclease VIII; Reviewed; Region: PRK09709 909946005545 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 909946005546 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 909946005547 dimer interface [polypeptide binding]; other site 909946005548 active site 909946005549 Int/Topo IB signature motif; other site 909946005550 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 909946005551 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 909946005552 hypothetical protein; Provisional; Region: PRK10301 909946005553 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 909946005554 Predicted amidohydrolase [General function prediction only]; Region: COG0388 909946005555 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 909946005556 exodeoxyribonuclease X; Provisional; Region: PRK07983 909946005557 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 909946005558 active site 909946005559 catalytic site [active] 909946005560 substrate binding site [chemical binding]; other site 909946005561 protease 2; Provisional; Region: PRK10115 909946005562 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 909946005563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 909946005564 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 909946005565 putative metal binding site [ion binding]; other site 909946005566 hypothetical protein; Provisional; Region: PRK13680 909946005567 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 909946005568 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 909946005569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 909946005570 ATP-grasp domain; Region: ATP-grasp; pfam02222 909946005571 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 909946005572 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 909946005573 active site 909946005574 intersubunit interface [polypeptide binding]; other site 909946005575 catalytic residue [active] 909946005576 phosphogluconate dehydratase; Validated; Region: PRK09054 909946005577 6-phosphogluconate dehydratase; Region: edd; TIGR01196 909946005578 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 909946005579 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 909946005580 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 909946005581 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 909946005582 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 909946005583 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 909946005584 putative active site [active] 909946005585 pyruvate kinase; Provisional; Region: PRK05826 909946005586 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 909946005587 domain interfaces; other site 909946005588 active site 909946005589 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 909946005590 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 909946005591 putative acyl-acceptor binding pocket; other site 909946005592 putative peptidase; Provisional; Region: PRK11649 909946005593 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 909946005594 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 909946005595 Peptidase family M23; Region: Peptidase_M23; pfam01551 909946005596 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 909946005597 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 909946005598 metal binding site [ion binding]; metal-binding site 909946005599 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 909946005600 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 909946005601 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 909946005602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909946005603 ABC-ATPase subunit interface; other site 909946005604 dimer interface [polypeptide binding]; other site 909946005605 putative PBP binding regions; other site 909946005606 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 909946005607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946005608 Walker A motif; other site 909946005609 ATP binding site [chemical binding]; other site 909946005610 Walker B motif; other site 909946005611 arginine finger; other site 909946005612 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 909946005613 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 909946005614 RuvA N terminal domain; Region: RuvA_N; pfam01330 909946005615 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 909946005616 hypothetical protein; Provisional; Region: PRK11470 909946005617 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 909946005618 active site 909946005619 putative DNA-binding cleft [nucleotide binding]; other site 909946005620 dimer interface [polypeptide binding]; other site 909946005621 hypothetical protein; Validated; Region: PRK00110 909946005622 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 909946005623 nudix motif; other site 909946005624 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 909946005625 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 909946005626 dimer interface [polypeptide binding]; other site 909946005627 anticodon binding site; other site 909946005628 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 909946005629 homodimer interface [polypeptide binding]; other site 909946005630 motif 1; other site 909946005631 active site 909946005632 motif 2; other site 909946005633 GAD domain; Region: GAD; pfam02938 909946005634 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 909946005635 active site 909946005636 motif 3; other site 909946005637 Isochorismatase family; Region: Isochorismatase; pfam00857 909946005638 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 909946005639 catalytic triad [active] 909946005640 conserved cis-peptide bond; other site 909946005641 hypothetical protein; Provisional; Region: PRK10302 909946005642 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 909946005643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946005644 S-adenosylmethionine binding site [chemical binding]; other site 909946005645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946005646 S-adenosylmethionine binding site [chemical binding]; other site 909946005647 copper homeostasis protein CutC; Provisional; Region: PRK11572 909946005648 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 909946005649 putative metal binding site [ion binding]; other site 909946005650 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 909946005651 arginyl-tRNA synthetase; Region: argS; TIGR00456 909946005652 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 909946005653 active site 909946005654 HIGH motif; other site 909946005655 KMSK motif region; other site 909946005656 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 909946005657 tRNA binding surface [nucleotide binding]; other site 909946005658 anticodon binding site; other site 909946005659 penicillin-binding protein 2; Provisional; Region: PRK10795 909946005660 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 909946005661 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 909946005662 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 909946005663 Flagellar protein FlhE; Region: FlhE; pfam06366 909946005664 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 909946005665 FHIPEP family; Region: FHIPEP; pfam00771 909946005666 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 909946005667 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 909946005668 chemotaxis regulator CheZ; Provisional; Region: PRK11166 909946005669 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 909946005670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946005671 active site 909946005672 phosphorylation site [posttranslational modification] 909946005673 intermolecular recognition site; other site 909946005674 dimerization interface [polypeptide binding]; other site 909946005675 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 909946005676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946005677 active site 909946005678 phosphorylation site [posttranslational modification] 909946005679 intermolecular recognition site; other site 909946005680 dimerization interface [polypeptide binding]; other site 909946005681 CheB methylesterase; Region: CheB_methylest; pfam01339 909946005682 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 909946005683 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 909946005684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946005685 S-adenosylmethionine binding site [chemical binding]; other site 909946005686 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 909946005687 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 909946005688 dimer interface [polypeptide binding]; other site 909946005689 ligand binding site [chemical binding]; other site 909946005690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946005691 dimerization interface [polypeptide binding]; other site 909946005692 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 909946005693 dimer interface [polypeptide binding]; other site 909946005694 putative CheW interface [polypeptide binding]; other site 909946005695 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 909946005696 putative CheA interaction surface; other site 909946005697 chemotaxis protein CheA; Provisional; Region: PRK10547 909946005698 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 909946005699 putative binding surface; other site 909946005700 active site 909946005701 CheY binding; Region: CheY-binding; pfam09078 909946005702 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 909946005703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946005704 ATP binding site [chemical binding]; other site 909946005705 Mg2+ binding site [ion binding]; other site 909946005706 G-X-G motif; other site 909946005707 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 909946005708 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 909946005709 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 909946005710 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 909946005711 ligand binding site [chemical binding]; other site 909946005712 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 909946005713 flagellar motor protein MotA; Validated; Region: PRK09110 909946005714 transcriptional activator FlhC; Provisional; Region: PRK12722 909946005715 transcriptional activator FlhD; Provisional; Region: PRK02909 909946005716 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 909946005717 Ligand Binding Site [chemical binding]; other site 909946005718 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 909946005719 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 909946005720 active site 909946005721 homotetramer interface [polypeptide binding]; other site 909946005722 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 909946005723 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 909946005724 DJ-1 family protein; Region: not_thiJ; TIGR01383 909946005725 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 909946005726 conserved cys residue [active] 909946005727 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 909946005728 Ferritin-like domain; Region: Ferritin; pfam00210 909946005729 ferroxidase diiron center [ion binding]; other site 909946005730 hypothetical protein; Provisional; Region: PRK09273 909946005731 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 909946005732 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 909946005733 YecR-like lipoprotein; Region: YecR; pfam13992 909946005734 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 909946005735 Ferritin-like domain; Region: Ferritin; pfam00210 909946005736 ferroxidase diiron center [ion binding]; other site 909946005737 probable metal-binding protein; Region: matur_matur; TIGR03853 909946005738 tyrosine transporter TyrP; Provisional; Region: PRK15132 909946005739 aromatic amino acid transport protein; Region: araaP; TIGR00837 909946005740 hypothetical protein; Provisional; Region: PRK10396 909946005741 yecA family protein; Region: ygfB_yecA; TIGR02292 909946005742 SEC-C motif; Region: SEC-C; pfam02810 909946005743 glucose-6-phosphate 1-dehydrogenase; Region: PLN02640 909946005744 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 909946005745 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 909946005746 NlpC/P60 family; Region: NLPC_P60; cl17555 909946005747 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 909946005748 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 909946005749 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 909946005750 GIY-YIG motif/motif A; other site 909946005751 active site 909946005752 catalytic site [active] 909946005753 putative DNA binding site [nucleotide binding]; other site 909946005754 metal binding site [ion binding]; metal-binding site 909946005755 UvrB/uvrC motif; Region: UVR; pfam02151 909946005756 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 909946005757 Helix-hairpin-helix motif; Region: HHH; pfam00633 909946005758 response regulator; Provisional; Region: PRK09483 909946005759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946005760 active site 909946005761 phosphorylation site [posttranslational modification] 909946005762 intermolecular recognition site; other site 909946005763 dimerization interface [polypeptide binding]; other site 909946005764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946005765 DNA binding residues [nucleotide binding] 909946005766 dimerization interface [polypeptide binding]; other site 909946005767 hypothetical protein; Provisional; Region: PRK10613 909946005768 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 909946005769 Autoinducer binding domain; Region: Autoind_bind; pfam03472 909946005770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946005771 DNA binding residues [nucleotide binding] 909946005772 dimerization interface [polypeptide binding]; other site 909946005773 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 909946005774 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 909946005775 Walker A/P-loop; other site 909946005776 ATP binding site [chemical binding]; other site 909946005777 Q-loop/lid; other site 909946005778 ABC transporter signature motif; other site 909946005779 Walker B; other site 909946005780 D-loop; other site 909946005781 H-loop/switch region; other site 909946005782 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 909946005783 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 909946005784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946005785 dimer interface [polypeptide binding]; other site 909946005786 conserved gate region; other site 909946005787 putative PBP binding loops; other site 909946005788 ABC-ATPase subunit interface; other site 909946005789 D-cysteine desulfhydrase; Validated; Region: PRK03910 909946005790 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 909946005791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946005792 catalytic residue [active] 909946005793 cystine transporter subunit; Provisional; Region: PRK11260 909946005794 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946005795 substrate binding pocket [chemical binding]; other site 909946005796 membrane-bound complex binding site; other site 909946005797 hinge residues; other site 909946005798 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 909946005799 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 909946005800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 909946005801 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 909946005802 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 909946005803 DNA binding residues [nucleotide binding] 909946005804 Transposase IS200 like; Region: Y1_Tnp; pfam01797 909946005805 flagellin; Validated; Region: PRK08026 909946005806 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 909946005807 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 909946005808 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 909946005809 flagellar capping protein; Reviewed; Region: fliD; PRK08032 909946005810 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 909946005811 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 909946005812 flagellar protein FliS; Validated; Region: fliS; PRK05685 909946005813 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 909946005814 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 909946005815 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 909946005816 active site 909946005817 Na/Ca binding site [ion binding]; other site 909946005818 catalytic site [active] 909946005819 lipoprotein; Provisional; Region: PRK10397 909946005820 putative inner membrane protein; Provisional; Region: PRK11099 909946005821 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 909946005822 CPxP motif; other site 909946005823 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 909946005824 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 909946005825 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 909946005826 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 909946005827 flagellar motor switch protein FliG; Region: fliG; TIGR00207 909946005828 FliG C-terminal domain; Region: FliG_C; pfam01706 909946005829 flagellar assembly protein H; Validated; Region: fliH; PRK05687 909946005830 Flagellar assembly protein FliH; Region: FliH; pfam02108 909946005831 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 909946005832 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 909946005833 Walker A motif/ATP binding site; other site 909946005834 Walker B motif; other site 909946005835 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 909946005836 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 909946005837 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 909946005838 flagellar hook-length control protein; Provisional; Region: PRK10118 909946005839 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 909946005840 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 909946005841 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 909946005842 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 909946005843 flagellar motor switch protein; Validated; Region: fliN; PRK05698 909946005844 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 909946005845 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 909946005846 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 909946005847 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 909946005848 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 909946005849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946005850 DNA binding residues [nucleotide binding] 909946005851 dimerization interface [polypeptide binding]; other site 909946005852 hypothetical protein; Provisional; Region: PRK10708 909946005853 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 909946005854 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 909946005855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946005856 active site 909946005857 motif I; other site 909946005858 motif II; other site 909946005859 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 909946005860 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 909946005861 metal binding site [ion binding]; metal-binding site 909946005862 active site 909946005863 I-site; other site 909946005864 Uncharacterized small protein [Function unknown]; Region: COG5475 909946005865 hypothetical protein; Provisional; Region: PRK10062 909946005866 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 909946005867 EamA-like transporter family; Region: EamA; pfam00892 909946005868 EamA-like transporter family; Region: EamA; pfam00892 909946005869 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 909946005870 additional DNA contacts [nucleotide binding]; other site 909946005871 mismatch recognition site; other site 909946005872 active site 909946005873 zinc binding site [ion binding]; other site 909946005874 DNA intercalation site [nucleotide binding]; other site 909946005875 DNA cytosine methylase; Provisional; Region: PRK10458 909946005876 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 909946005877 cofactor binding site; other site 909946005878 DNA binding site [nucleotide binding] 909946005879 substrate interaction site [chemical binding]; other site 909946005880 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 909946005881 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 909946005882 Zn2+ binding site [ion binding]; other site 909946005883 Mg2+ binding site [ion binding]; other site 909946005884 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 909946005885 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 909946005886 trimer interface [polypeptide binding]; other site 909946005887 eyelet of channel; other site 909946005888 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 909946005889 DNA-binding site [nucleotide binding]; DNA binding site 909946005890 RNA-binding motif; other site 909946005891 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 909946005892 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 909946005893 active site 909946005894 DNA binding site [nucleotide binding] 909946005895 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 909946005896 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 909946005897 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 909946005898 Catalytic site [active] 909946005899 type III secretion system protein; Provisional; Region: PRK15383 909946005900 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 909946005901 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 909946005902 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 909946005903 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 909946005904 Phage protein GP46; Region: GP46; pfam07409 909946005905 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 909946005906 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 909946005907 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 909946005908 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 909946005909 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 909946005910 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 909946005911 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 909946005912 Phage tail tube protein; Region: Tail_tube; pfam10618 909946005913 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 909946005914 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 909946005915 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 909946005916 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 909946005917 oligomerization interface [polypeptide binding]; other site 909946005918 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 909946005919 Phage capsid family; Region: Phage_capsid; pfam05065 909946005920 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 909946005921 Phage-related protein [Function unknown]; Region: COG4695 909946005922 Phage portal protein; Region: Phage_portal; pfam04860 909946005923 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 909946005924 Phage terminase, small subunit; Region: Terminase_4; pfam05119 909946005925 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 909946005926 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 909946005927 active site 909946005928 KilA-N domain; Region: KilA-N; pfam04383 909946005929 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 909946005930 Predicted chitinase [General function prediction only]; Region: COG3179 909946005931 catalytic residue [active] 909946005932 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 909946005933 Protein of unknown function (DUF968); Region: DUF968; pfam06147 909946005934 KilA-N domain; Region: KilA-N; pfam04383 909946005935 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 909946005936 Helix-turn-helix domain; Region: HTH_36; pfam13730 909946005937 Ash protein family; Region: Phage_ASH; pfam10554 909946005938 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 909946005939 Predicted transcriptional regulator [Transcription]; Region: COG2932 909946005940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946005941 non-specific DNA binding site [nucleotide binding]; other site 909946005942 salt bridge; other site 909946005943 sequence-specific DNA binding site [nucleotide binding]; other site 909946005944 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 909946005945 Catalytic site [active] 909946005946 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 909946005947 HD domain; Region: HD_3; cl17350 909946005948 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 909946005949 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 909946005950 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 909946005951 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 909946005952 dimer interface [polypeptide binding]; other site 909946005953 active site 909946005954 Int/Topo IB signature motif; other site 909946005955 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 909946005956 putative protease; Region: PHA00666 909946005957 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 909946005958 Integrase; Region: Integrase_1; pfam12835 909946005959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 909946005960 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 909946005961 Sel1-like repeats; Region: SEL1; smart00671 909946005962 Sel1-like repeats; Region: SEL1; smart00671 909946005963 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 909946005964 AMP nucleosidase; Provisional; Region: PRK08292 909946005965 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 909946005966 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 909946005967 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 909946005968 MATE family multidrug exporter; Provisional; Region: PRK10189 909946005969 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 909946005970 L,D-transpeptidase; Provisional; Region: PRK10190 909946005971 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 909946005972 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 909946005973 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 909946005974 putative dimer interface [polypeptide binding]; other site 909946005975 active site pocket [active] 909946005976 putative cataytic base [active] 909946005977 cobalamin synthase; Reviewed; Region: cobS; PRK00235 909946005978 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 909946005979 homotrimer interface [polypeptide binding]; other site 909946005980 Walker A motif; other site 909946005981 GTP binding site [chemical binding]; other site 909946005982 Walker B motif; other site 909946005983 cobyric acid synthase; Provisional; Region: PRK00784 909946005984 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 909946005985 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 909946005986 catalytic triad [active] 909946005987 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 909946005988 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 909946005989 Walker A/P-loop; other site 909946005990 ATP binding site [chemical binding]; other site 909946005991 Q-loop/lid; other site 909946005992 ABC transporter signature motif; other site 909946005993 Walker B; other site 909946005994 D-loop; other site 909946005995 H-loop/switch region; other site 909946005996 cobalt transport protein CbiQ; Provisional; Region: PRK15485 909946005997 cobalt transport protein CbiN; Provisional; Region: PRK02898 909946005998 cobalt transport protein CbiM; Validated; Region: PRK08319 909946005999 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 909946006000 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 909946006001 active site 909946006002 SAM binding site [chemical binding]; other site 909946006003 homodimer interface [polypeptide binding]; other site 909946006004 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 909946006005 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 909946006006 active site 909946006007 C-terminal domain interface [polypeptide binding]; other site 909946006008 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 909946006009 active site 909946006010 N-terminal domain interface [polypeptide binding]; other site 909946006011 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 909946006012 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 909946006013 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 909946006014 active site 909946006015 SAM binding site [chemical binding]; other site 909946006016 homodimer interface [polypeptide binding]; other site 909946006017 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 909946006018 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 909946006019 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 909946006020 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 909946006021 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 909946006022 active site 909946006023 SAM binding site [chemical binding]; other site 909946006024 homodimer interface [polypeptide binding]; other site 909946006025 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 909946006026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946006027 S-adenosylmethionine binding site [chemical binding]; other site 909946006028 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 909946006029 active site 909946006030 putative homodimer interface [polypeptide binding]; other site 909946006031 SAM binding site [chemical binding]; other site 909946006032 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 909946006033 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 909946006034 Precorrin-8X methylmutase; Region: CbiC; pfam02570 909946006035 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 909946006036 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 909946006037 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 909946006038 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 909946006039 catalytic triad [active] 909946006040 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 909946006041 Sensory domain found in PocR; Region: PocR; pfam10114 909946006042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946006043 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 909946006044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946006045 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 909946006046 amphipathic channel; other site 909946006047 Asn-Pro-Ala signature motifs; other site 909946006048 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 909946006049 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 909946006050 Hexamer interface [polypeptide binding]; other site 909946006051 Putative hexagonal pore residue; other site 909946006052 propanediol utilization protein PduB; Provisional; Region: PRK15415 909946006053 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 909946006054 putative hexamer interface [polypeptide binding]; other site 909946006055 putative hexagonal pore; other site 909946006056 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 909946006057 putative hexamer interface [polypeptide binding]; other site 909946006058 putative hexagonal pore; other site 909946006059 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 909946006060 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 909946006061 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 909946006062 alpha-beta subunit interface [polypeptide binding]; other site 909946006063 alpha-gamma subunit interface [polypeptide binding]; other site 909946006064 active site 909946006065 substrate and K+ binding site; other site 909946006066 K+ binding site [ion binding]; other site 909946006067 cobalamin binding site [chemical binding]; other site 909946006068 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 909946006069 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 909946006070 Cell division protein FtsA; Region: FtsA; cl17206 909946006071 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 909946006072 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 909946006073 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 909946006074 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 909946006075 Hexamer interface [polypeptide binding]; other site 909946006076 Putative hexagonal pore residue; other site 909946006077 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 909946006078 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 909946006079 putative hexamer interface [polypeptide binding]; other site 909946006080 putative hexagonal pore; other site 909946006081 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 909946006082 Propanediol utilisation protein PduL; Region: PduL; pfam06130 909946006083 Propanediol utilisation protein PduL; Region: PduL; pfam06130 909946006084 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 909946006085 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 909946006086 Hexamer/Pentamer interface [polypeptide binding]; other site 909946006087 central pore; other site 909946006088 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 909946006089 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 909946006090 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 909946006091 putative catalytic cysteine [active] 909946006092 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 909946006093 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 909946006094 putative active site [active] 909946006095 metal binding site [ion binding]; metal-binding site 909946006096 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 909946006097 SLBB domain; Region: SLBB; pfam10531 909946006098 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 909946006099 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 909946006100 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 909946006101 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 909946006102 putative hexamer interface [polypeptide binding]; other site 909946006103 putative hexagonal pore; other site 909946006104 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 909946006105 putative hexamer interface [polypeptide binding]; other site 909946006106 putative hexagonal pore; other site 909946006107 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 909946006108 putative hexamer interface [polypeptide binding]; other site 909946006109 putative hexagonal pore; other site 909946006110 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 909946006111 G3 box; other site 909946006112 Switch II region; other site 909946006113 GTP/Mg2+ binding site [chemical binding]; other site 909946006114 G4 box; other site 909946006115 G5 box; other site 909946006116 propionate kinase; Reviewed; Region: PRK12397 909946006117 propionate/acetate kinase; Provisional; Region: PRK12379 909946006118 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 909946006119 hypothetical protein; Provisional; Region: PRK05423 909946006120 Predicted membrane protein [Function unknown]; Region: COG1289 909946006121 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 909946006122 DNA gyrase inhibitor; Provisional; Region: PRK10016 909946006123 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 909946006124 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 909946006125 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 909946006126 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 909946006127 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 909946006128 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 909946006129 4Fe-4S binding domain; Region: Fer4; cl02805 909946006130 thiosulfate reductase PhsA; Provisional; Region: PRK15488 909946006131 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 909946006132 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 909946006133 putative [Fe4-S4] binding site [ion binding]; other site 909946006134 putative molybdopterin cofactor binding site [chemical binding]; other site 909946006135 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 909946006136 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 909946006137 putative molybdopterin cofactor binding site; other site 909946006138 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 909946006139 SopA-like central domain; Region: SopA; pfam13981 909946006140 SopA-like catalytic domain; Region: SopA_C; pfam13979 909946006141 exonuclease I; Provisional; Region: sbcB; PRK11779 909946006142 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 909946006143 active site 909946006144 catalytic site [active] 909946006145 substrate binding site [chemical binding]; other site 909946006146 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 909946006147 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 909946006148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946006149 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 909946006150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 909946006151 dimerization interface [polypeptide binding]; other site 909946006152 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 909946006153 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 909946006154 putative NAD(P) binding site [chemical binding]; other site 909946006155 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 909946006156 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 909946006157 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 909946006158 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 909946006159 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 909946006160 NAD binding site [chemical binding]; other site 909946006161 dimerization interface [polypeptide binding]; other site 909946006162 product binding site; other site 909946006163 substrate binding site [chemical binding]; other site 909946006164 zinc binding site [ion binding]; other site 909946006165 catalytic residues [active] 909946006166 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 909946006167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909946006168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946006169 homodimer interface [polypeptide binding]; other site 909946006170 catalytic residue [active] 909946006171 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 909946006172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946006173 active site 909946006174 motif I; other site 909946006175 motif II; other site 909946006176 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 909946006177 putative active site pocket [active] 909946006178 4-fold oligomerization interface [polypeptide binding]; other site 909946006179 metal binding residues [ion binding]; metal-binding site 909946006180 3-fold/trimer interface [polypeptide binding]; other site 909946006181 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 909946006182 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 909946006183 putative active site [active] 909946006184 oxyanion strand; other site 909946006185 catalytic triad [active] 909946006186 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 909946006187 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 909946006188 catalytic residues [active] 909946006189 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 909946006190 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 909946006191 substrate binding site [chemical binding]; other site 909946006192 glutamase interaction surface [polypeptide binding]; other site 909946006193 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 909946006194 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 909946006195 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 909946006196 metal binding site [ion binding]; metal-binding site 909946006197 chain length determinant protein WzzB; Provisional; Region: PRK15471 909946006198 Chain length determinant protein; Region: Wzz; pfam02706 909946006199 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 909946006200 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 909946006201 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 909946006202 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 909946006203 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 909946006204 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 909946006205 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 909946006206 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 909946006207 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 909946006208 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 909946006209 Bacterial sugar transferase; Region: Bac_transf; pfam02397 909946006210 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 909946006211 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 909946006212 active site 909946006213 substrate binding site [chemical binding]; other site 909946006214 metal binding site [ion binding]; metal-binding site 909946006215 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 909946006216 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 909946006217 Substrate binding site; other site 909946006218 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 909946006219 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 909946006220 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 909946006221 active site 909946006222 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 909946006223 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 909946006224 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 909946006225 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 909946006226 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 909946006227 active site 909946006228 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 909946006229 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 909946006230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 909946006231 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 909946006232 NAD(P) binding site [chemical binding]; other site 909946006233 active site 909946006234 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 909946006235 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 909946006236 inhibitor-cofactor binding pocket; inhibition site 909946006237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946006238 catalytic residue [active] 909946006239 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 909946006240 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 909946006241 NAD binding site [chemical binding]; other site 909946006242 homotetramer interface [polypeptide binding]; other site 909946006243 homodimer interface [polypeptide binding]; other site 909946006244 substrate binding site [chemical binding]; other site 909946006245 active site 909946006246 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 909946006247 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 909946006248 substrate binding site; other site 909946006249 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 909946006250 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 909946006251 catalytic loop [active] 909946006252 iron binding site [ion binding]; other site 909946006253 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 909946006254 FAD binding pocket [chemical binding]; other site 909946006255 FAD binding motif [chemical binding]; other site 909946006256 phosphate binding motif [ion binding]; other site 909946006257 beta-alpha-beta structure motif; other site 909946006258 NAD binding pocket [chemical binding]; other site 909946006259 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 909946006260 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 909946006261 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 909946006262 substrate binding site; other site 909946006263 tetramer interface; other site 909946006264 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 909946006265 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 909946006266 NADP binding site [chemical binding]; other site 909946006267 active site 909946006268 putative substrate binding site [chemical binding]; other site 909946006269 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 909946006270 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 909946006271 NAD binding site [chemical binding]; other site 909946006272 substrate binding site [chemical binding]; other site 909946006273 homodimer interface [polypeptide binding]; other site 909946006274 active site 909946006275 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 909946006276 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 909946006277 active site 909946006278 tetramer interface; other site 909946006279 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 909946006280 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 909946006281 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 909946006282 putative ADP-binding pocket [chemical binding]; other site 909946006283 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 909946006284 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 909946006285 colanic acid exporter; Provisional; Region: PRK10459 909946006286 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 909946006287 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 909946006288 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 909946006289 phosphomannomutase CpsG; Provisional; Region: PRK15414 909946006290 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 909946006291 active site 909946006292 substrate binding site [chemical binding]; other site 909946006293 metal binding site [ion binding]; metal-binding site 909946006294 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 909946006295 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 909946006296 Substrate binding site; other site 909946006297 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 909946006298 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 909946006299 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 909946006300 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 909946006301 active site 909946006302 GDP-Mannose binding site [chemical binding]; other site 909946006303 dimer interface [polypeptide binding]; other site 909946006304 modified nudix motif 909946006305 metal binding site [ion binding]; metal-binding site 909946006306 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 909946006307 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 909946006308 NADP binding site [chemical binding]; other site 909946006309 active site 909946006310 putative substrate binding site [chemical binding]; other site 909946006311 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 909946006312 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 909946006313 NADP-binding site; other site 909946006314 homotetramer interface [polypeptide binding]; other site 909946006315 substrate binding site [chemical binding]; other site 909946006316 homodimer interface [polypeptide binding]; other site 909946006317 active site 909946006318 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 909946006319 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 909946006320 putative trimer interface [polypeptide binding]; other site 909946006321 putative active site [active] 909946006322 putative substrate binding site [chemical binding]; other site 909946006323 putative CoA binding site [chemical binding]; other site 909946006324 putative glycosyl transferase; Provisional; Region: PRK10063 909946006325 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 909946006326 metal-binding site 909946006327 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 909946006328 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 909946006329 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 909946006330 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 909946006331 putative acyl transferase; Provisional; Region: PRK10191 909946006332 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 909946006333 trimer interface [polypeptide binding]; other site 909946006334 active site 909946006335 substrate binding site [chemical binding]; other site 909946006336 CoA binding site [chemical binding]; other site 909946006337 putative glycosyl transferase; Provisional; Region: PRK10018 909946006338 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 909946006339 active site 909946006340 tyrosine kinase; Provisional; Region: PRK11519 909946006341 Chain length determinant protein; Region: Wzz; pfam02706 909946006342 Chain length determinant protein; Region: Wzz; cl15801 909946006343 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 909946006344 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 909946006345 Low molecular weight phosphatase family; Region: LMWPc; cd00115 909946006346 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 909946006347 active site 909946006348 polysaccharide export protein Wza; Provisional; Region: PRK15078 909946006349 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 909946006350 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 909946006351 FOG: CBS domain [General function prediction only]; Region: COG0517 909946006352 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 909946006353 Transporter associated domain; Region: CorC_HlyC; smart01091 909946006354 putative assembly protein; Provisional; Region: PRK10833 909946006355 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 909946006356 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 909946006357 trimer interface [polypeptide binding]; other site 909946006358 active site 909946006359 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 909946006360 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 909946006361 ATP-binding site [chemical binding]; other site 909946006362 Sugar specificity; other site 909946006363 Pyrimidine base specificity; other site 909946006364 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 909946006365 PAS domain S-box; Region: sensory_box; TIGR00229 909946006366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 909946006367 putative active site [active] 909946006368 heme pocket [chemical binding]; other site 909946006369 PAS domain S-box; Region: sensory_box; TIGR00229 909946006370 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 909946006371 putative active site [active] 909946006372 heme pocket [chemical binding]; other site 909946006373 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 909946006374 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 909946006375 metal binding site [ion binding]; metal-binding site 909946006376 active site 909946006377 I-site; other site 909946006378 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946006379 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 909946006380 AlkA N-terminal domain; Region: AlkA_N; pfam06029 909946006381 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 909946006382 minor groove reading motif; other site 909946006383 helix-hairpin-helix signature motif; other site 909946006384 substrate binding pocket [chemical binding]; other site 909946006385 active site 909946006386 putative chaperone; Provisional; Region: PRK11678 909946006387 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 909946006388 nucleotide binding site [chemical binding]; other site 909946006389 putative NEF/HSP70 interaction site [polypeptide binding]; other site 909946006390 SBD interface [polypeptide binding]; other site 909946006391 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 909946006392 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 909946006393 HlyD family secretion protein; Region: HlyD_3; pfam13437 909946006394 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 909946006395 Protein export membrane protein; Region: SecD_SecF; cl14618 909946006396 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 909946006397 putative transporter; Provisional; Region: PRK10504 909946006398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946006399 putative substrate translocation pore; other site 909946006400 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 909946006401 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946006402 dimerization interface [polypeptide binding]; other site 909946006403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946006404 dimer interface [polypeptide binding]; other site 909946006405 phosphorylation site [posttranslational modification] 909946006406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946006407 ATP binding site [chemical binding]; other site 909946006408 Mg2+ binding site [ion binding]; other site 909946006409 G-X-G motif; other site 909946006410 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 909946006411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946006412 active site 909946006413 phosphorylation site [posttranslational modification] 909946006414 intermolecular recognition site; other site 909946006415 dimerization interface [polypeptide binding]; other site 909946006416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946006417 DNA binding site [nucleotide binding] 909946006418 PcfJ-like protein; Region: PcfJ; pfam14284 909946006419 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 909946006420 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 909946006421 putative protease; Provisional; Region: PRK15452 909946006422 Peptidase family U32; Region: Peptidase_U32; pfam01136 909946006423 type III secretion system protein; Provisional; Region: PRK15383 909946006424 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 909946006425 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 909946006426 lipid kinase; Reviewed; Region: PRK13054 909946006427 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 909946006428 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 909946006429 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 909946006430 putative active site; other site 909946006431 catalytic residue [active] 909946006432 nucleoside transporter; Region: 2A0110; TIGR00889 909946006433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946006434 putative substrate translocation pore; other site 909946006435 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 909946006436 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909946006437 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 909946006438 substrate binding site [chemical binding]; other site 909946006439 ATP binding site [chemical binding]; other site 909946006440 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 909946006441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946006442 DNA-binding site [nucleotide binding]; DNA binding site 909946006443 UTRA domain; Region: UTRA; pfam07702 909946006444 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 909946006445 dimer interface [polypeptide binding]; other site 909946006446 substrate binding site [chemical binding]; other site 909946006447 ATP binding site [chemical binding]; other site 909946006448 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 909946006449 substrate binding site [chemical binding]; other site 909946006450 multimerization interface [polypeptide binding]; other site 909946006451 ATP binding site [chemical binding]; other site 909946006452 Predicted integral membrane protein [Function unknown]; Region: COG5455 909946006453 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 909946006454 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 909946006455 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 909946006456 PapC N-terminal domain; Region: PapC_N; pfam13954 909946006457 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 909946006458 PapC C-terminal domain; Region: PapC_C; pfam13953 909946006459 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 909946006460 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946006461 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946006462 fimbrial chaperone protein; Provisional; Region: PRK15220 909946006463 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 909946006464 antiporter inner membrane protein; Provisional; Region: PRK11670 909946006465 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 909946006466 Walker A motif; other site 909946006467 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 909946006468 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 909946006469 active site 909946006470 HIGH motif; other site 909946006471 KMSKS motif; other site 909946006472 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 909946006473 tRNA binding surface [nucleotide binding]; other site 909946006474 anticodon binding site; other site 909946006475 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 909946006476 dimer interface [polypeptide binding]; other site 909946006477 putative tRNA-binding site [nucleotide binding]; other site 909946006478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 909946006479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 909946006480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 909946006481 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 909946006482 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 909946006483 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 909946006484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946006485 active site 909946006486 phosphorylation site [posttranslational modification] 909946006487 intermolecular recognition site; other site 909946006488 dimerization interface [polypeptide binding]; other site 909946006489 LytTr DNA-binding domain; Region: LytTR; pfam04397 909946006490 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 909946006491 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 909946006492 GAF domain; Region: GAF; pfam01590 909946006493 Histidine kinase; Region: His_kinase; pfam06580 909946006494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946006495 ATP binding site [chemical binding]; other site 909946006496 Mg2+ binding site [ion binding]; other site 909946006497 G-X-G motif; other site 909946006498 transcriptional regulator MirA; Provisional; Region: PRK15043 909946006499 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 909946006500 DNA binding residues [nucleotide binding] 909946006501 hypothetical protein; Provisional; Region: PRK13681 909946006502 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 909946006503 putative PBP binding loops; other site 909946006504 ABC-ATPase subunit interface; other site 909946006505 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 909946006506 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 909946006507 Walker A/P-loop; other site 909946006508 ATP binding site [chemical binding]; other site 909946006509 Q-loop/lid; other site 909946006510 ABC transporter signature motif; other site 909946006511 Walker B; other site 909946006512 D-loop; other site 909946006513 H-loop/switch region; other site 909946006514 CBS domain; Region: CBS; pfam00571 909946006515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946006516 dimer interface [polypeptide binding]; other site 909946006517 conserved gate region; other site 909946006518 ABC-ATPase subunit interface; other site 909946006519 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 909946006520 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 909946006521 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 909946006522 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 909946006523 D-lactate dehydrogenase; Provisional; Region: PRK11183 909946006524 FAD binding domain; Region: FAD_binding_4; pfam01565 909946006525 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 909946006526 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 909946006527 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 909946006528 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 909946006529 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 909946006530 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 909946006531 oxidoreductase; Provisional; Region: PRK12743 909946006532 classical (c) SDRs; Region: SDR_c; cd05233 909946006533 NAD(P) binding site [chemical binding]; other site 909946006534 active site 909946006535 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 909946006536 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 909946006537 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 909946006538 FMN binding site [chemical binding]; other site 909946006539 active site 909946006540 catalytic residues [active] 909946006541 substrate binding site [chemical binding]; other site 909946006542 salicylate hydroxylase; Provisional; Region: PRK08163 909946006543 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 909946006544 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 909946006545 maleylacetoacetate isomerase; Region: maiA; TIGR01262 909946006546 C-terminal domain interface [polypeptide binding]; other site 909946006547 GSH binding site (G-site) [chemical binding]; other site 909946006548 putative dimer interface [polypeptide binding]; other site 909946006549 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 909946006550 dimer interface [polypeptide binding]; other site 909946006551 N-terminal domain interface [polypeptide binding]; other site 909946006552 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 909946006553 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 909946006554 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 909946006555 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 909946006556 Cupin domain; Region: Cupin_2; pfam07883 909946006557 Cupin domain; Region: Cupin_2; pfam07883 909946006558 benzoate transport; Region: 2A0115; TIGR00895 909946006559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946006560 putative substrate translocation pore; other site 909946006561 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 909946006562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946006563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 909946006564 dimerization interface [polypeptide binding]; other site 909946006565 hypothetical protein; Provisional; Region: PRK01821 909946006566 hypothetical protein; Provisional; Region: PRK10711 909946006567 cytidine deaminase; Provisional; Region: PRK09027 909946006568 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 909946006569 active site 909946006570 catalytic motif [active] 909946006571 Zn binding site [ion binding]; other site 909946006572 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 909946006573 active site 909946006574 catalytic motif [active] 909946006575 Zn binding site [ion binding]; other site 909946006576 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 909946006577 putative active site [active] 909946006578 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 909946006579 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 909946006580 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909946006581 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909946006582 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 909946006583 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 909946006584 homodimer interface [polypeptide binding]; other site 909946006585 active site 909946006586 FMN binding site [chemical binding]; other site 909946006587 substrate binding site [chemical binding]; other site 909946006588 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 909946006589 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 909946006590 TM-ABC transporter signature motif; other site 909946006591 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 909946006592 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 909946006593 Walker A/P-loop; other site 909946006594 ATP binding site [chemical binding]; other site 909946006595 Q-loop/lid; other site 909946006596 ABC transporter signature motif; other site 909946006597 Walker B; other site 909946006598 D-loop; other site 909946006599 H-loop/switch region; other site 909946006600 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 909946006601 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 909946006602 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 909946006603 ligand binding site [chemical binding]; other site 909946006604 calcium binding site [ion binding]; other site 909946006605 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 909946006606 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946006607 DNA binding site [nucleotide binding] 909946006608 domain linker motif; other site 909946006609 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 909946006610 dimerization interface (closed form) [polypeptide binding]; other site 909946006611 ligand binding site [chemical binding]; other site 909946006612 Predicted membrane protein [Function unknown]; Region: COG2311 909946006613 hypothetical protein; Provisional; Region: PRK10835 909946006614 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 909946006615 GTP cyclohydrolase I; Provisional; Region: PLN03044 909946006616 active site 909946006617 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 909946006618 S-formylglutathione hydrolase; Region: PLN02442 909946006619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 909946006620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946006621 non-specific DNA binding site [nucleotide binding]; other site 909946006622 salt bridge; other site 909946006623 sequence-specific DNA binding site [nucleotide binding]; other site 909946006624 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 909946006625 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 909946006626 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 909946006627 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 909946006628 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 909946006629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946006630 motif II; other site 909946006631 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 909946006632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946006633 putative substrate translocation pore; other site 909946006634 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 909946006635 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 909946006636 N-terminal plug; other site 909946006637 ligand-binding site [chemical binding]; other site 909946006638 lysine transporter; Provisional; Region: PRK10836 909946006639 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 909946006640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946006641 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 909946006642 putative dimerization interface [polypeptide binding]; other site 909946006643 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 909946006644 endonuclease IV; Provisional; Region: PRK01060 909946006645 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 909946006646 AP (apurinic/apyrimidinic) site pocket; other site 909946006647 DNA interaction; other site 909946006648 Metal-binding active site; metal-binding site 909946006649 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 909946006650 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 909946006651 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 909946006652 active site 909946006653 P-loop; other site 909946006654 phosphorylation site [posttranslational modification] 909946006655 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 909946006656 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 909946006657 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 909946006658 putative substrate binding site [chemical binding]; other site 909946006659 putative ATP binding site [chemical binding]; other site 909946006660 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 909946006661 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909946006662 active site 909946006663 phosphorylation site [posttranslational modification] 909946006664 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 909946006665 dimerization domain swap beta strand [polypeptide binding]; other site 909946006666 regulatory protein interface [polypeptide binding]; other site 909946006667 active site 909946006668 regulatory phosphorylation site [posttranslational modification]; other site 909946006669 sugar efflux transporter B; Provisional; Region: PRK15011 909946006670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946006671 putative substrate translocation pore; other site 909946006672 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 909946006673 Flagellin N-methylase; Region: FliB; cl00497 909946006674 elongation factor P; Provisional; Region: PRK04542 909946006675 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 909946006676 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 909946006677 RNA binding site [nucleotide binding]; other site 909946006678 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 909946006679 RNA binding site [nucleotide binding]; other site 909946006680 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 909946006681 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 909946006682 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 909946006683 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 909946006684 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 909946006685 active site 909946006686 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 909946006687 NlpC/P60 family; Region: NLPC_P60; pfam00877 909946006688 phage resistance protein; Provisional; Region: PRK10551 909946006689 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 909946006690 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946006691 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 909946006692 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 909946006693 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 909946006694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946006695 dimer interface [polypeptide binding]; other site 909946006696 conserved gate region; other site 909946006697 putative PBP binding loops; other site 909946006698 ABC-ATPase subunit interface; other site 909946006699 microcin C ABC transporter permease; Provisional; Region: PRK15021 909946006700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946006701 dimer interface [polypeptide binding]; other site 909946006702 conserved gate region; other site 909946006703 ABC-ATPase subunit interface; other site 909946006704 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 909946006705 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909946006706 Walker A/P-loop; other site 909946006707 ATP binding site [chemical binding]; other site 909946006708 Q-loop/lid; other site 909946006709 ABC transporter signature motif; other site 909946006710 Walker B; other site 909946006711 D-loop; other site 909946006712 H-loop/switch region; other site 909946006713 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 909946006714 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909946006715 Walker A/P-loop; other site 909946006716 ATP binding site [chemical binding]; other site 909946006717 Q-loop/lid; other site 909946006718 ABC transporter signature motif; other site 909946006719 Walker B; other site 909946006720 D-loop; other site 909946006721 H-loop/switch region; other site 909946006722 hypothetical protein; Provisional; Region: PRK11835 909946006723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946006724 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 909946006725 putative substrate translocation pore; other site 909946006726 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 909946006727 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909946006728 RNA binding surface [nucleotide binding]; other site 909946006729 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 909946006730 active site 909946006731 uracil binding [chemical binding]; other site 909946006732 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 909946006733 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909946006734 ATP binding site [chemical binding]; other site 909946006735 putative Mg++ binding site [ion binding]; other site 909946006736 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946006737 nucleotide binding region [chemical binding]; other site 909946006738 ATP-binding site [chemical binding]; other site 909946006739 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 909946006740 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 909946006741 5S rRNA interface [nucleotide binding]; other site 909946006742 CTC domain interface [polypeptide binding]; other site 909946006743 L16 interface [polypeptide binding]; other site 909946006744 Nucleoid-associated protein [General function prediction only]; Region: COG3081 909946006745 nucleoid-associated protein NdpA; Validated; Region: PRK00378 909946006746 hypothetical protein; Provisional; Region: PRK13689 909946006747 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 909946006748 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 909946006749 Sulfatase; Region: Sulfatase; cl17466 909946006750 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 909946006751 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 909946006752 Catalytic site [active] 909946006753 DinI-like family; Region: DinI; cl11630 909946006754 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 909946006755 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 909946006756 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 909946006757 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 909946006758 Phage head maturation protease [General function prediction only]; Region: COG3740 909946006759 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 909946006760 Phage-related protein [Function unknown]; Region: COG4695; cl01923 909946006761 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 909946006762 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 909946006763 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 909946006764 Protein of unknown function (DUF968); Region: DUF968; pfam06147 909946006765 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 909946006766 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 909946006767 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 909946006768 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 909946006769 Leucine-rich repeats; other site 909946006770 Substrate binding site [chemical binding]; other site 909946006771 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 909946006772 DinI-like family; Region: DinI; cl11630 909946006773 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 909946006774 transcriptional regulator NarP; Provisional; Region: PRK10403 909946006775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946006776 active site 909946006777 phosphorylation site [posttranslational modification] 909946006778 intermolecular recognition site; other site 909946006779 dimerization interface [polypeptide binding]; other site 909946006780 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946006781 DNA binding residues [nucleotide binding] 909946006782 dimerization interface [polypeptide binding]; other site 909946006783 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 909946006784 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 909946006785 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 909946006786 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 909946006787 catalytic residues [active] 909946006788 central insert; other site 909946006789 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 909946006790 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 909946006791 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 909946006792 heme exporter protein CcmC; Region: ccmC; TIGR01191 909946006793 heme exporter protein CcmB; Region: ccmB; TIGR01190 909946006794 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 909946006795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946006796 Walker A/P-loop; other site 909946006797 ATP binding site [chemical binding]; other site 909946006798 Q-loop/lid; other site 909946006799 ABC transporter signature motif; other site 909946006800 Walker B; other site 909946006801 D-loop; other site 909946006802 H-loop/switch region; other site 909946006803 cytochrome c-type protein NapC; Provisional; Region: PRK10617 909946006804 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 909946006805 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 909946006806 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 909946006807 4Fe-4S binding domain; Region: Fer4_5; pfam12801 909946006808 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 909946006809 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 909946006810 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 909946006811 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 909946006812 [4Fe-4S] binding site [ion binding]; other site 909946006813 molybdopterin cofactor binding site; other site 909946006814 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 909946006815 molybdopterin cofactor binding site; other site 909946006816 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 909946006817 ferredoxin-type protein; Provisional; Region: PRK10194 909946006818 4Fe-4S binding domain; Region: Fer4; cl02805 909946006819 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 909946006820 secondary substrate binding site; other site 909946006821 primary substrate binding site; other site 909946006822 inhibition loop; other site 909946006823 dimerization interface [polypeptide binding]; other site 909946006824 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 909946006825 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 909946006826 Walker A/P-loop; other site 909946006827 ATP binding site [chemical binding]; other site 909946006828 Q-loop/lid; other site 909946006829 ABC transporter signature motif; other site 909946006830 Walker B; other site 909946006831 D-loop; other site 909946006832 H-loop/switch region; other site 909946006833 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 909946006834 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 909946006835 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 909946006836 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946006837 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 909946006838 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 909946006839 DNA binding site [nucleotide binding] 909946006840 active site 909946006841 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 909946006842 ApbE family; Region: ApbE; pfam02424 909946006843 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 909946006844 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 909946006845 trimer interface [polypeptide binding]; other site 909946006846 eyelet of channel; other site 909946006847 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 909946006848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946006849 ATP binding site [chemical binding]; other site 909946006850 G-X-G motif; other site 909946006851 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 909946006852 putative binding surface; other site 909946006853 active site 909946006854 transcriptional regulator RcsB; Provisional; Region: PRK10840 909946006855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946006856 active site 909946006857 phosphorylation site [posttranslational modification] 909946006858 intermolecular recognition site; other site 909946006859 dimerization interface [polypeptide binding]; other site 909946006860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946006861 DNA binding residues [nucleotide binding] 909946006862 dimerization interface [polypeptide binding]; other site 909946006863 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 909946006864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946006865 dimer interface [polypeptide binding]; other site 909946006866 phosphorylation site [posttranslational modification] 909946006867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946006868 ATP binding site [chemical binding]; other site 909946006869 Mg2+ binding site [ion binding]; other site 909946006870 G-X-G motif; other site 909946006871 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 909946006872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946006873 active site 909946006874 phosphorylation site [posttranslational modification] 909946006875 intermolecular recognition site; other site 909946006876 dimerization interface [polypeptide binding]; other site 909946006877 DNA gyrase subunit A; Validated; Region: PRK05560 909946006878 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 909946006879 CAP-like domain; other site 909946006880 active site 909946006881 primary dimer interface [polypeptide binding]; other site 909946006882 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 909946006883 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 909946006884 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 909946006885 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 909946006886 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 909946006887 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 909946006888 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 909946006889 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 909946006890 active site pocket [active] 909946006891 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 909946006892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946006893 putative substrate translocation pore; other site 909946006894 Transcriptional regulators [Transcription]; Region: GntR; COG1802 909946006895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946006896 DNA-binding site [nucleotide binding]; DNA binding site 909946006897 FCD domain; Region: FCD; pfam07729 909946006898 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 909946006899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946006900 S-adenosylmethionine binding site [chemical binding]; other site 909946006901 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 909946006902 ATP cone domain; Region: ATP-cone; pfam03477 909946006903 Class I ribonucleotide reductase; Region: RNR_I; cd01679 909946006904 active site 909946006905 dimer interface [polypeptide binding]; other site 909946006906 catalytic residues [active] 909946006907 effector binding site; other site 909946006908 R2 peptide binding site; other site 909946006909 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 909946006910 dimer interface [polypeptide binding]; other site 909946006911 putative radical transfer pathway; other site 909946006912 diiron center [ion binding]; other site 909946006913 tyrosyl radical; other site 909946006914 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 909946006915 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 909946006916 catalytic loop [active] 909946006917 iron binding site [ion binding]; other site 909946006918 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909946006919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946006920 putative substrate translocation pore; other site 909946006921 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 909946006922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946006923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 909946006924 dimerization interface [polypeptide binding]; other site 909946006925 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 909946006926 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 909946006927 active site 909946006928 catalytic site [active] 909946006929 metal binding site [ion binding]; metal-binding site 909946006930 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 909946006931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946006932 putative substrate translocation pore; other site 909946006933 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 909946006934 hydroxyglutarate oxidase; Provisional; Region: PRK11728 909946006935 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 909946006936 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 909946006937 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 909946006938 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 909946006939 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 909946006940 Cysteine-rich domain; Region: CCG; pfam02754 909946006941 Cysteine-rich domain; Region: CCG; pfam02754 909946006942 deubiquitinase SseL; Provisional; Region: PRK14848 909946006943 hypothetical protein; Provisional; Region: PRK03673 909946006944 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 909946006945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946006946 D-galactonate transporter; Region: 2A0114; TIGR00893 909946006947 putative substrate translocation pore; other site 909946006948 L-rhamnonate dehydratase; Provisional; Region: PRK15440 909946006949 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 909946006950 putative active site pocket [active] 909946006951 putative metal binding site [ion binding]; other site 909946006952 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 909946006953 Transcriptional regulator [Transcription]; Region: IclR; COG1414 909946006954 Bacterial transcriptional regulator; Region: IclR; pfam01614 909946006955 hypothetical protein; Provisional; Region: PRK03673 909946006956 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 909946006957 putative MPT binding site; other site 909946006958 Competence-damaged protein; Region: CinA; cl00666 909946006959 YfaZ precursor; Region: YfaZ; pfam07437 909946006960 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 909946006961 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 909946006962 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 909946006963 catalytic core [active] 909946006964 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 909946006965 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 909946006966 inhibitor-cofactor binding pocket; inhibition site 909946006967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946006968 catalytic residue [active] 909946006969 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 909946006970 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 909946006971 Ligand binding site; other site 909946006972 Putative Catalytic site; other site 909946006973 DXD motif; other site 909946006974 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 909946006975 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 909946006976 active site 909946006977 substrate binding site [chemical binding]; other site 909946006978 cosubstrate binding site; other site 909946006979 catalytic site [active] 909946006980 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 909946006981 active site 909946006982 hexamer interface [polypeptide binding]; other site 909946006983 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 909946006984 NAD binding site [chemical binding]; other site 909946006985 substrate binding site [chemical binding]; other site 909946006986 active site 909946006987 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 909946006988 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 909946006989 putative active site [active] 909946006990 putative catalytic site [active] 909946006991 putative Zn binding site [ion binding]; other site 909946006992 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 909946006993 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 909946006994 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 909946006995 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 909946006996 signal transduction protein PmrD; Provisional; Region: PRK15450 909946006997 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 909946006998 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 909946006999 acyl-activating enzyme (AAE) consensus motif; other site 909946007000 putative AMP binding site [chemical binding]; other site 909946007001 putative active site [active] 909946007002 putative CoA binding site [chemical binding]; other site 909946007003 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 909946007004 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 909946007005 active site 909946007006 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 909946007007 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 909946007008 substrate binding site [chemical binding]; other site 909946007009 oxyanion hole (OAH) forming residues; other site 909946007010 trimer interface [polypeptide binding]; other site 909946007011 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 909946007012 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 909946007013 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 909946007014 dimer interface [polypeptide binding]; other site 909946007015 tetramer interface [polypeptide binding]; other site 909946007016 PYR/PP interface [polypeptide binding]; other site 909946007017 TPP binding site [chemical binding]; other site 909946007018 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 909946007019 TPP-binding site; other site 909946007020 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 909946007021 isochorismate synthases; Region: isochor_syn; TIGR00543 909946007022 hypothetical protein; Provisional; Region: PRK10404 909946007023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946007024 Coenzyme A binding pocket [chemical binding]; other site 909946007025 ribonuclease BN; Region: true_RNase_BN; TIGR02649 909946007026 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 909946007027 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 909946007028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946007029 active site 909946007030 phosphorylation site [posttranslational modification] 909946007031 intermolecular recognition site; other site 909946007032 dimerization interface [polypeptide binding]; other site 909946007033 von Willebrand factor; Region: vWF_A; pfam12450 909946007034 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 909946007035 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 909946007036 metal ion-dependent adhesion site (MIDAS); other site 909946007037 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 909946007038 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 909946007039 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 909946007040 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 909946007041 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 909946007042 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 909946007043 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 909946007044 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 909946007045 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 909946007046 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 909946007047 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 909946007048 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 909946007049 4Fe-4S binding domain; Region: Fer4; pfam00037 909946007050 4Fe-4S binding domain; Region: Fer4; pfam00037 909946007051 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 909946007052 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 909946007053 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 909946007054 catalytic loop [active] 909946007055 iron binding site [ion binding]; other site 909946007056 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 909946007057 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 909946007058 [4Fe-4S] binding site [ion binding]; other site 909946007059 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 909946007060 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 909946007061 SLBB domain; Region: SLBB; pfam10531 909946007062 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 909946007063 NADH dehydrogenase subunit E; Validated; Region: PRK07539 909946007064 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 909946007065 putative dimer interface [polypeptide binding]; other site 909946007066 [2Fe-2S] cluster binding site [ion binding]; other site 909946007067 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 909946007068 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 909946007069 NADH dehydrogenase subunit D; Validated; Region: PRK06075 909946007070 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 909946007071 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 909946007072 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 909946007073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946007074 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 909946007075 putative dimerization interface [polypeptide binding]; other site 909946007076 aminotransferase AlaT; Validated; Region: PRK09265 909946007077 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909946007078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946007079 homodimer interface [polypeptide binding]; other site 909946007080 catalytic residue [active] 909946007081 5'-nucleotidase; Provisional; Region: PRK03826 909946007082 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 909946007083 transmembrane helices; other site 909946007084 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 909946007085 TrkA-C domain; Region: TrkA_C; pfam02080 909946007086 TrkA-C domain; Region: TrkA_C; pfam02080 909946007087 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 909946007088 putative phosphatase; Provisional; Region: PRK11587 909946007089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946007090 motif II; other site 909946007091 hypothetical protein; Validated; Region: PRK05445 909946007092 hypothetical protein; Provisional; Region: PRK01816 909946007093 propionate/acetate kinase; Provisional; Region: PRK12379 909946007094 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 909946007095 phosphate acetyltransferase; Reviewed; Region: PRK05632 909946007096 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 909946007097 DRTGG domain; Region: DRTGG; pfam07085 909946007098 phosphate acetyltransferase; Region: pta; TIGR00651 909946007099 hypothetical protein; Provisional; Region: PRK11588 909946007100 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 909946007101 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 909946007102 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 909946007103 PYR/PP interface [polypeptide binding]; other site 909946007104 dimer interface [polypeptide binding]; other site 909946007105 TPP binding site [chemical binding]; other site 909946007106 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 909946007107 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 909946007108 TPP-binding site [chemical binding]; other site 909946007109 dimer interface [polypeptide binding]; other site 909946007110 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 909946007111 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 909946007112 active site 909946007113 P-loop; other site 909946007114 phosphorylation site [posttranslational modification] 909946007115 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909946007116 active site 909946007117 phosphorylation site [posttranslational modification] 909946007118 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909946007119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946007120 DNA binding site [nucleotide binding] 909946007121 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 909946007122 putative dimerization interface [polypeptide binding]; other site 909946007123 putative ligand binding site [chemical binding]; other site 909946007124 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 909946007125 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 909946007126 nudix motif; other site 909946007127 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 909946007128 active site 909946007129 metal binding site [ion binding]; metal-binding site 909946007130 homotetramer interface [polypeptide binding]; other site 909946007131 glutathione S-transferase; Provisional; Region: PRK15113 909946007132 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 909946007133 C-terminal domain interface [polypeptide binding]; other site 909946007134 GSH binding site (G-site) [chemical binding]; other site 909946007135 dimer interface [polypeptide binding]; other site 909946007136 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 909946007137 N-terminal domain interface [polypeptide binding]; other site 909946007138 putative dimer interface [polypeptide binding]; other site 909946007139 putative substrate binding pocket (H-site) [chemical binding]; other site 909946007140 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 909946007141 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 909946007142 C-terminal domain interface [polypeptide binding]; other site 909946007143 GSH binding site (G-site) [chemical binding]; other site 909946007144 dimer interface [polypeptide binding]; other site 909946007145 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 909946007146 N-terminal domain interface [polypeptide binding]; other site 909946007147 putative dimer interface [polypeptide binding]; other site 909946007148 active site 909946007149 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 909946007150 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 909946007151 putative NAD(P) binding site [chemical binding]; other site 909946007152 putative active site [active] 909946007153 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 909946007154 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 909946007155 Walker A/P-loop; other site 909946007156 ATP binding site [chemical binding]; other site 909946007157 Q-loop/lid; other site 909946007158 ABC transporter signature motif; other site 909946007159 Walker B; other site 909946007160 D-loop; other site 909946007161 H-loop/switch region; other site 909946007162 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 909946007163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946007164 dimer interface [polypeptide binding]; other site 909946007165 conserved gate region; other site 909946007166 putative PBP binding loops; other site 909946007167 ABC-ATPase subunit interface; other site 909946007168 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 909946007169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946007170 dimer interface [polypeptide binding]; other site 909946007171 conserved gate region; other site 909946007172 putative PBP binding loops; other site 909946007173 ABC-ATPase subunit interface; other site 909946007174 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 909946007175 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946007176 substrate binding pocket [chemical binding]; other site 909946007177 membrane-bound complex binding site; other site 909946007178 hinge residues; other site 909946007179 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 909946007180 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946007181 substrate binding pocket [chemical binding]; other site 909946007182 membrane-bound complex binding site; other site 909946007183 hinge residues; other site 909946007184 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 909946007185 Flavoprotein; Region: Flavoprotein; pfam02441 909946007186 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 909946007187 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 909946007188 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 909946007189 dimer interface [polypeptide binding]; other site 909946007190 active site 909946007191 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 909946007192 substrate binding site [chemical binding]; other site 909946007193 catalytic residue [active] 909946007194 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 909946007195 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 909946007196 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 909946007197 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 909946007198 catalytic residue [active] 909946007199 PAS fold; Region: PAS_4; pfam08448 909946007200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 909946007201 putative active site [active] 909946007202 heme pocket [chemical binding]; other site 909946007203 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 909946007204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946007205 Walker A motif; other site 909946007206 ATP binding site [chemical binding]; other site 909946007207 Walker B motif; other site 909946007208 arginine finger; other site 909946007209 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 909946007210 amidophosphoribosyltransferase; Provisional; Region: PRK09246 909946007211 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 909946007212 active site 909946007213 tetramer interface [polypeptide binding]; other site 909946007214 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909946007215 active site 909946007216 colicin V production protein; Provisional; Region: PRK10845 909946007217 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 909946007218 cell division protein DedD; Provisional; Region: PRK11633 909946007219 Sporulation related domain; Region: SPOR; pfam05036 909946007220 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 909946007221 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 909946007222 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 909946007223 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 909946007224 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 909946007225 hypothetical protein; Provisional; Region: PRK10847 909946007226 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 909946007227 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 909946007228 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 909946007229 dimerization interface 3.5A [polypeptide binding]; other site 909946007230 active site 909946007231 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 909946007232 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 909946007233 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 909946007234 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 909946007235 ligand binding site [chemical binding]; other site 909946007236 NAD binding site [chemical binding]; other site 909946007237 catalytic site [active] 909946007238 homodimer interface [polypeptide binding]; other site 909946007239 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 909946007240 putative transporter; Provisional; Region: PRK12382 909946007241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946007242 putative substrate translocation pore; other site 909946007243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946007244 non-specific DNA binding site [nucleotide binding]; other site 909946007245 salt bridge; other site 909946007246 sequence-specific DNA binding site [nucleotide binding]; other site 909946007247 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 909946007248 CAAX protease self-immunity; Region: Abi; pfam02517 909946007249 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 909946007250 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 909946007251 dimer interface [polypeptide binding]; other site 909946007252 active site 909946007253 Uncharacterized conserved protein [Function unknown]; Region: COG4121 909946007254 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 909946007255 YfcL protein; Region: YfcL; pfam08891 909946007256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 909946007257 hypothetical protein; Provisional; Region: PRK10621 909946007258 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 909946007259 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 909946007260 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 909946007261 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 909946007262 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 909946007263 Tetramer interface [polypeptide binding]; other site 909946007264 active site 909946007265 FMN-binding site [chemical binding]; other site 909946007266 HemK family putative methylases; Region: hemK_fam; TIGR00536 909946007267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946007268 S-adenosylmethionine binding site [chemical binding]; other site 909946007269 hypothetical protein; Provisional; Region: PRK04946 909946007270 Smr domain; Region: Smr; pfam01713 909946007271 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 909946007272 catalytic core [active] 909946007273 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 909946007274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 909946007275 substrate binding site [chemical binding]; other site 909946007276 oxyanion hole (OAH) forming residues; other site 909946007277 trimer interface [polypeptide binding]; other site 909946007278 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 909946007279 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 909946007280 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 909946007281 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 909946007282 dimer interface [polypeptide binding]; other site 909946007283 active site 909946007284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 909946007285 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 909946007286 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 909946007287 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 909946007288 outer membrane protease; Reviewed; Region: PRK10993 909946007289 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 909946007290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946007291 active site 909946007292 phosphorylation site [posttranslational modification] 909946007293 intermolecular recognition site; other site 909946007294 dimerization interface [polypeptide binding]; other site 909946007295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 909946007296 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 909946007297 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 909946007298 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 909946007299 dimerization interface [polypeptide binding]; other site 909946007300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946007301 dimer interface [polypeptide binding]; other site 909946007302 phosphorylation site [posttranslational modification] 909946007303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946007304 ATP binding site [chemical binding]; other site 909946007305 Mg2+ binding site [ion binding]; other site 909946007306 G-X-G motif; other site 909946007307 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 909946007308 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 909946007309 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 909946007310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946007311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946007312 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 909946007313 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 909946007314 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 909946007315 putative acyl-acceptor binding pocket; other site 909946007316 aminotransferase; Validated; Region: PRK08175 909946007317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909946007318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946007319 homodimer interface [polypeptide binding]; other site 909946007320 catalytic residue [active] 909946007321 glucokinase; Provisional; Region: glk; PRK00292 909946007322 glucokinase, proteobacterial type; Region: glk; TIGR00749 909946007323 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 909946007324 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 909946007325 Cl- selectivity filter; other site 909946007326 Cl- binding residues [ion binding]; other site 909946007327 pore gating glutamate residue; other site 909946007328 dimer interface [polypeptide binding]; other site 909946007329 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 909946007330 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 909946007331 dimer interface [polypeptide binding]; other site 909946007332 PYR/PP interface [polypeptide binding]; other site 909946007333 TPP binding site [chemical binding]; other site 909946007334 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 909946007335 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 909946007336 TPP-binding site [chemical binding]; other site 909946007337 dimer interface [polypeptide binding]; other site 909946007338 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909946007339 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909946007340 active site 909946007341 catalytic tetrad [active] 909946007342 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 909946007343 manganese transport protein MntH; Reviewed; Region: PRK00701 909946007344 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 909946007345 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 909946007346 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 909946007347 Nucleoside recognition; Region: Gate; pfam07670 909946007348 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 909946007349 MASE1; Region: MASE1; pfam05231 909946007350 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 909946007351 diguanylate cyclase; Region: GGDEF; smart00267 909946007352 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946007353 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 909946007354 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 909946007355 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 909946007356 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 909946007357 active site 909946007358 HIGH motif; other site 909946007359 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 909946007360 active site 909946007361 KMSKS motif; other site 909946007362 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 909946007363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946007364 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 909946007365 putative dimerization interface [polypeptide binding]; other site 909946007366 putative substrate binding pocket [chemical binding]; other site 909946007367 XapX domain; Region: XapX; TIGR03510 909946007368 nucleoside transporter; Region: 2A0110; TIGR00889 909946007369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946007370 putative substrate translocation pore; other site 909946007371 purine nucleoside phosphorylase; Provisional; Region: PRK08202 909946007372 hypothetical protein; Provisional; Region: PRK11528 909946007373 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946007374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946007375 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 909946007376 putative dimerization interface [polypeptide binding]; other site 909946007377 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 909946007378 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 909946007379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 909946007380 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 909946007381 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 909946007382 nucleotide binding pocket [chemical binding]; other site 909946007383 K-X-D-G motif; other site 909946007384 catalytic site [active] 909946007385 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 909946007386 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 909946007387 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 909946007388 Dimer interface [polypeptide binding]; other site 909946007389 BRCT sequence motif; other site 909946007390 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 909946007391 cell division protein ZipA; Provisional; Region: PRK03427 909946007392 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 909946007393 FtsZ protein binding site [polypeptide binding]; other site 909946007394 putative sulfate transport protein CysZ; Validated; Region: PRK04949 909946007395 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 909946007396 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 909946007397 dimer interface [polypeptide binding]; other site 909946007398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946007399 catalytic residue [active] 909946007400 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 909946007401 dimerization domain swap beta strand [polypeptide binding]; other site 909946007402 regulatory protein interface [polypeptide binding]; other site 909946007403 active site 909946007404 regulatory phosphorylation site [posttranslational modification]; other site 909946007405 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 909946007406 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 909946007407 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 909946007408 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 909946007409 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 909946007410 HPr interaction site; other site 909946007411 glycerol kinase (GK) interaction site [polypeptide binding]; other site 909946007412 active site 909946007413 phosphorylation site [posttranslational modification] 909946007414 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 909946007415 dimer interface [polypeptide binding]; other site 909946007416 pyridoxamine kinase; Validated; Region: PRK05756 909946007417 pyridoxal binding site [chemical binding]; other site 909946007418 ATP binding site [chemical binding]; other site 909946007419 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 909946007420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946007421 DNA-binding site [nucleotide binding]; DNA binding site 909946007422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909946007423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946007424 homodimer interface [polypeptide binding]; other site 909946007425 catalytic residue [active] 909946007426 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 909946007427 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 909946007428 catalytic triad [active] 909946007429 hypothetical protein; Provisional; Region: PRK10318 909946007430 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 909946007431 Transglycosylase; Region: Transgly; cl17702 909946007432 cysteine synthase B; Region: cysM; TIGR01138 909946007433 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 909946007434 dimer interface [polypeptide binding]; other site 909946007435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946007436 catalytic residue [active] 909946007437 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 909946007438 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 909946007439 Walker A/P-loop; other site 909946007440 ATP binding site [chemical binding]; other site 909946007441 Q-loop/lid; other site 909946007442 ABC transporter signature motif; other site 909946007443 Walker B; other site 909946007444 D-loop; other site 909946007445 H-loop/switch region; other site 909946007446 TOBE-like domain; Region: TOBE_3; pfam12857 909946007447 sulfate transport protein; Provisional; Region: cysT; CHL00187 909946007448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946007449 dimer interface [polypeptide binding]; other site 909946007450 conserved gate region; other site 909946007451 putative PBP binding loops; other site 909946007452 ABC-ATPase subunit interface; other site 909946007453 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 909946007454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946007455 dimer interface [polypeptide binding]; other site 909946007456 conserved gate region; other site 909946007457 putative PBP binding loops; other site 909946007458 ABC-ATPase subunit interface; other site 909946007459 thiosulfate transporter subunit; Provisional; Region: PRK10852 909946007460 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 909946007461 short chain dehydrogenase; Provisional; Region: PRK08226 909946007462 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 909946007463 NAD binding site [chemical binding]; other site 909946007464 homotetramer interface [polypeptide binding]; other site 909946007465 homodimer interface [polypeptide binding]; other site 909946007466 active site 909946007467 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 909946007468 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 909946007469 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 909946007470 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 909946007471 putative acetyltransferase; Provisional; Region: PRK03624 909946007472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946007473 Coenzyme A binding pocket [chemical binding]; other site 909946007474 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 909946007475 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 909946007476 active site 909946007477 metal binding site [ion binding]; metal-binding site 909946007478 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 909946007479 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 909946007480 transcriptional regulator EutR; Provisional; Region: PRK10130 909946007481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946007482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946007483 carboxysome structural protein EutK; Provisional; Region: PRK15466 909946007484 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 909946007485 Hexamer interface [polypeptide binding]; other site 909946007486 Hexagonal pore residue; other site 909946007487 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 909946007488 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 909946007489 putative hexamer interface [polypeptide binding]; other site 909946007490 putative hexagonal pore; other site 909946007491 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 909946007492 putative hexamer interface [polypeptide binding]; other site 909946007493 putative hexagonal pore; other site 909946007494 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 909946007495 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 909946007496 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 909946007497 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 909946007498 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 909946007499 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 909946007500 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 909946007501 active site 909946007502 metal binding site [ion binding]; metal-binding site 909946007503 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 909946007504 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 909946007505 nucleotide binding site [chemical binding]; other site 909946007506 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 909946007507 putative catalytic cysteine [active] 909946007508 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 909946007509 Hexamer/Pentamer interface [polypeptide binding]; other site 909946007510 central pore; other site 909946007511 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 909946007512 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 909946007513 Hexamer interface [polypeptide binding]; other site 909946007514 Putative hexagonal pore residue; other site 909946007515 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 909946007516 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 909946007517 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 909946007518 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 909946007519 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 909946007520 G1 box; other site 909946007521 GTP/Mg2+ binding site [chemical binding]; other site 909946007522 G2 box; other site 909946007523 Switch I region; other site 909946007524 G3 box; other site 909946007525 Switch II region; other site 909946007526 G4 box; other site 909946007527 G5 box; other site 909946007528 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 909946007529 putative hexamer interface [polypeptide binding]; other site 909946007530 putative hexagonal pore; other site 909946007531 Transposase IS200 like; Region: Y1_Tnp; pfam01797 909946007532 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 909946007533 Malic enzyme, N-terminal domain; Region: malic; pfam00390 909946007534 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 909946007535 putative NAD(P) binding site [chemical binding]; other site 909946007536 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 909946007537 transaldolase-like protein; Provisional; Region: PTZ00411 909946007538 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 909946007539 active site 909946007540 dimer interface [polypeptide binding]; other site 909946007541 catalytic residue [active] 909946007542 transketolase; Reviewed; Region: PRK12753 909946007543 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 909946007544 TPP-binding site [chemical binding]; other site 909946007545 dimer interface [polypeptide binding]; other site 909946007546 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 909946007547 PYR/PP interface [polypeptide binding]; other site 909946007548 dimer interface [polypeptide binding]; other site 909946007549 TPP binding site [chemical binding]; other site 909946007550 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 909946007551 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 909946007552 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 909946007553 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 909946007554 dimer interface [polypeptide binding]; other site 909946007555 ADP-ribose binding site [chemical binding]; other site 909946007556 active site 909946007557 nudix motif; other site 909946007558 metal binding site [ion binding]; metal-binding site 909946007559 putative periplasmic esterase; Provisional; Region: PRK03642 909946007560 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 909946007561 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 909946007562 4Fe-4S binding domain; Region: Fer4; pfam00037 909946007563 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 909946007564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909946007565 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 909946007566 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 909946007567 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946007568 dimerization interface [polypeptide binding]; other site 909946007569 Histidine kinase; Region: HisKA_3; pfam07730 909946007570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946007571 ATP binding site [chemical binding]; other site 909946007572 Mg2+ binding site [ion binding]; other site 909946007573 G-X-G motif; other site 909946007574 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 909946007575 Protein export membrane protein; Region: SecD_SecF; cl14618 909946007576 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 909946007577 ArsC family; Region: ArsC; pfam03960 909946007578 putative catalytic residues [active] 909946007579 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 909946007580 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 909946007581 metal binding site [ion binding]; metal-binding site 909946007582 dimer interface [polypeptide binding]; other site 909946007583 hypothetical protein; Provisional; Region: PRK13664 909946007584 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 909946007585 Helicase; Region: Helicase_RecD; pfam05127 909946007586 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 909946007587 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 909946007588 Predicted metalloprotease [General function prediction only]; Region: COG2321 909946007589 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 909946007590 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 909946007591 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 909946007592 ATP binding site [chemical binding]; other site 909946007593 active site 909946007594 substrate binding site [chemical binding]; other site 909946007595 lipoprotein; Provisional; Region: PRK11679 909946007596 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 909946007597 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 909946007598 dihydrodipicolinate synthase; Region: dapA; TIGR00674 909946007599 dimer interface [polypeptide binding]; other site 909946007600 active site 909946007601 catalytic residue [active] 909946007602 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 909946007603 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 909946007604 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 909946007605 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 909946007606 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 909946007607 catalytic triad [active] 909946007608 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 909946007609 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 909946007610 Domain of unknown function DUF20; Region: UPF0118; pfam01594 909946007611 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 909946007612 Peptidase family M48; Region: Peptidase_M48; cl12018 909946007613 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 909946007614 ArsC family; Region: ArsC; pfam03960 909946007615 catalytic residues [active] 909946007616 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 909946007617 DNA replication initiation factor; Provisional; Region: PRK08084 909946007618 uracil transporter; Provisional; Region: PRK10720 909946007619 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909946007620 active site 909946007621 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 909946007622 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 909946007623 dimerization interface [polypeptide binding]; other site 909946007624 putative ATP binding site [chemical binding]; other site 909946007625 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 909946007626 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 909946007627 active site 909946007628 substrate binding site [chemical binding]; other site 909946007629 cosubstrate binding site; other site 909946007630 catalytic site [active] 909946007631 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 909946007632 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 909946007633 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 909946007634 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 909946007635 putative active site [active] 909946007636 catalytic site [active] 909946007637 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 909946007638 domain interface [polypeptide binding]; other site 909946007639 active site 909946007640 catalytic site [active] 909946007641 exopolyphosphatase; Provisional; Region: PRK10854 909946007642 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 909946007643 nucleotide binding site [chemical binding]; other site 909946007644 MASE1; Region: MASE1; pfam05231 909946007645 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 909946007646 diguanylate cyclase; Region: GGDEF; smart00267 909946007647 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946007648 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 909946007649 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 909946007650 Integrase core domain; Region: rve; pfam00665 909946007651 GMP synthase; Reviewed; Region: guaA; PRK00074 909946007652 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 909946007653 AMP/PPi binding site [chemical binding]; other site 909946007654 candidate oxyanion hole; other site 909946007655 catalytic triad [active] 909946007656 potential glutamine specificity residues [chemical binding]; other site 909946007657 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 909946007658 ATP Binding subdomain [chemical binding]; other site 909946007659 Ligand Binding sites [chemical binding]; other site 909946007660 Dimerization subdomain; other site 909946007661 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 909946007662 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 909946007663 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 909946007664 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 909946007665 active site 909946007666 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 909946007667 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 909946007668 generic binding surface II; other site 909946007669 generic binding surface I; other site 909946007670 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 909946007671 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 909946007672 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 909946007673 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 909946007674 Autotransporter beta-domain; Region: Autotransporter; smart00869 909946007675 outer membrane protein RatA; Provisional; Region: PRK15315 909946007676 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 909946007677 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 909946007678 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 909946007679 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 909946007680 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 909946007681 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 909946007682 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 909946007683 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 909946007684 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 909946007685 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 909946007686 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 909946007687 intimin-like protein SinH; Provisional; Region: PRK15318 909946007688 intimin-like protein SinH; Provisional; Region: PRK15318 909946007689 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 909946007690 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 909946007691 GTP-binding protein Der; Reviewed; Region: PRK00093 909946007692 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 909946007693 G1 box; other site 909946007694 GTP/Mg2+ binding site [chemical binding]; other site 909946007695 Switch I region; other site 909946007696 G2 box; other site 909946007697 Switch II region; other site 909946007698 G3 box; other site 909946007699 G4 box; other site 909946007700 G5 box; other site 909946007701 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 909946007702 G1 box; other site 909946007703 GTP/Mg2+ binding site [chemical binding]; other site 909946007704 Switch I region; other site 909946007705 G2 box; other site 909946007706 G3 box; other site 909946007707 Switch II region; other site 909946007708 G4 box; other site 909946007709 G5 box; other site 909946007710 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 909946007711 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 909946007712 Trp docking motif [polypeptide binding]; other site 909946007713 active site 909946007714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 909946007715 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 909946007716 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 909946007717 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 909946007718 dimer interface [polypeptide binding]; other site 909946007719 motif 1; other site 909946007720 active site 909946007721 motif 2; other site 909946007722 motif 3; other site 909946007723 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 909946007724 anticodon binding site; other site 909946007725 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 909946007726 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 909946007727 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 909946007728 cytoskeletal protein RodZ; Provisional; Region: PRK10856 909946007729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946007730 non-specific DNA binding site [nucleotide binding]; other site 909946007731 salt bridge; other site 909946007732 sequence-specific DNA binding site [nucleotide binding]; other site 909946007733 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 909946007734 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 909946007735 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946007736 FeS/SAM binding site; other site 909946007737 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 909946007738 active site 909946007739 multimer interface [polypeptide binding]; other site 909946007740 4Fe-4S binding domain; Region: Fer4; pfam00037 909946007741 hydrogenase 4 subunit H; Validated; Region: PRK08222 909946007742 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 909946007743 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 909946007744 4Fe-4S binding domain; Region: Fer4; pfam00037 909946007745 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 909946007746 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 909946007747 putative [Fe4-S4] binding site [ion binding]; other site 909946007748 putative molybdopterin cofactor binding site [chemical binding]; other site 909946007749 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 909946007750 putative molybdopterin cofactor binding site; other site 909946007751 penicillin-binding protein 1C; Provisional; Region: PRK11240 909946007752 Transglycosylase; Region: Transgly; pfam00912 909946007753 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 909946007754 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 909946007755 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 909946007756 MG2 domain; Region: A2M_N; pfam01835 909946007757 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 909946007758 surface patch; other site 909946007759 thioester region; other site 909946007760 specificity defining residues; other site 909946007761 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 909946007762 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 909946007763 active site residue [active] 909946007764 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 909946007765 active site residue [active] 909946007766 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 909946007767 aminopeptidase B; Provisional; Region: PRK05015 909946007768 Peptidase; Region: DUF3663; pfam12404 909946007769 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 909946007770 interface (dimer of trimers) [polypeptide binding]; other site 909946007771 Substrate-binding/catalytic site; other site 909946007772 Zn-binding sites [ion binding]; other site 909946007773 hypothetical protein; Provisional; Region: PRK10721 909946007774 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 909946007775 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 909946007776 catalytic loop [active] 909946007777 iron binding site [ion binding]; other site 909946007778 chaperone protein HscA; Provisional; Region: hscA; PRK05183 909946007779 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 909946007780 nucleotide binding site [chemical binding]; other site 909946007781 putative NEF/HSP70 interaction site [polypeptide binding]; other site 909946007782 SBD interface [polypeptide binding]; other site 909946007783 co-chaperone HscB; Provisional; Region: hscB; PRK05014 909946007784 DnaJ domain; Region: DnaJ; pfam00226 909946007785 HSP70 interaction site [polypeptide binding]; other site 909946007786 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 909946007787 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 909946007788 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 909946007789 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 909946007790 trimerization site [polypeptide binding]; other site 909946007791 active site 909946007792 cysteine desulfurase; Provisional; Region: PRK14012 909946007793 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 909946007794 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909946007795 catalytic residue [active] 909946007796 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 909946007797 Rrf2 family protein; Region: rrf2_super; TIGR00738 909946007798 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 909946007799 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 909946007800 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 909946007801 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 909946007802 active site 909946007803 dimerization interface [polypeptide binding]; other site 909946007804 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 909946007805 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 909946007806 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 909946007807 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 909946007808 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 909946007809 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 909946007810 FAD binding pocket [chemical binding]; other site 909946007811 FAD binding motif [chemical binding]; other site 909946007812 phosphate binding motif [ion binding]; other site 909946007813 beta-alpha-beta structure motif; other site 909946007814 NAD binding pocket [chemical binding]; other site 909946007815 Iron coordination center [ion binding]; other site 909946007816 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 909946007817 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 909946007818 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 909946007819 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 909946007820 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 909946007821 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 909946007822 PRD domain; Region: PRD; pfam00874 909946007823 PRD domain; Region: PRD; pfam00874 909946007824 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 909946007825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946007826 putative substrate translocation pore; other site 909946007827 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 909946007828 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 909946007829 dimer interface [polypeptide binding]; other site 909946007830 active site 909946007831 glycine-pyridoxal phosphate binding site [chemical binding]; other site 909946007832 folate binding site [chemical binding]; other site 909946007833 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 909946007834 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 909946007835 heme-binding site [chemical binding]; other site 909946007836 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 909946007837 FAD binding pocket [chemical binding]; other site 909946007838 FAD binding motif [chemical binding]; other site 909946007839 phosphate binding motif [ion binding]; other site 909946007840 beta-alpha-beta structure motif; other site 909946007841 NAD binding pocket [chemical binding]; other site 909946007842 Heme binding pocket [chemical binding]; other site 909946007843 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 909946007844 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946007845 DNA binding site [nucleotide binding] 909946007846 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 909946007847 lysine decarboxylase CadA; Provisional; Region: PRK15400 909946007848 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 909946007849 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 909946007850 homodimer interface [polypeptide binding]; other site 909946007851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946007852 catalytic residue [active] 909946007853 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 909946007854 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 909946007855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946007856 putative substrate translocation pore; other site 909946007857 POT family; Region: PTR2; pfam00854 909946007858 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 909946007859 Nitrogen regulatory protein P-II; Region: P-II; smart00938 909946007860 response regulator GlrR; Provisional; Region: PRK15115 909946007861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946007862 active site 909946007863 phosphorylation site [posttranslational modification] 909946007864 intermolecular recognition site; other site 909946007865 dimerization interface [polypeptide binding]; other site 909946007866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946007867 Walker A motif; other site 909946007868 ATP binding site [chemical binding]; other site 909946007869 Walker B motif; other site 909946007870 arginine finger; other site 909946007871 hypothetical protein; Provisional; Region: PRK10722 909946007872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 909946007873 HAMP domain; Region: HAMP; pfam00672 909946007874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946007875 dimer interface [polypeptide binding]; other site 909946007876 phosphorylation site [posttranslational modification] 909946007877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946007878 ATP binding site [chemical binding]; other site 909946007879 Mg2+ binding site [ion binding]; other site 909946007880 G-X-G motif; other site 909946007881 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 909946007882 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 909946007883 dimerization interface [polypeptide binding]; other site 909946007884 ATP binding site [chemical binding]; other site 909946007885 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 909946007886 dimerization interface [polypeptide binding]; other site 909946007887 ATP binding site [chemical binding]; other site 909946007888 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 909946007889 putative active site [active] 909946007890 catalytic triad [active] 909946007891 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 909946007892 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946007893 substrate binding pocket [chemical binding]; other site 909946007894 membrane-bound complex binding site; other site 909946007895 hinge residues; other site 909946007896 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 909946007897 N-acetyl-D-glucosamine binding site [chemical binding]; other site 909946007898 catalytic residue [active] 909946007899 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 909946007900 nucleoside/Zn binding site; other site 909946007901 dimer interface [polypeptide binding]; other site 909946007902 catalytic motif [active] 909946007903 hypothetical protein; Provisional; Region: PRK11590 909946007904 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 909946007905 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 909946007906 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 909946007907 active site turn [active] 909946007908 phosphorylation site [posttranslational modification] 909946007909 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 909946007910 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 909946007911 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 909946007912 putative active site [active] 909946007913 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 909946007914 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 909946007915 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 909946007916 putative active site [active] 909946007917 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 909946007918 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 909946007919 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 909946007920 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 909946007921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946007922 putative substrate translocation pore; other site 909946007923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946007924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946007925 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 909946007926 dimerization interface [polypeptide binding]; other site 909946007927 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 909946007928 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 909946007929 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 909946007930 active site 909946007931 hydrophilic channel; other site 909946007932 dimerization interface [polypeptide binding]; other site 909946007933 catalytic residues [active] 909946007934 active site lid [active] 909946007935 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 909946007936 Recombination protein O N terminal; Region: RecO_N; pfam11967 909946007937 Recombination protein O C terminal; Region: RecO_C; pfam02565 909946007938 GTPase Era; Reviewed; Region: era; PRK00089 909946007939 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 909946007940 G1 box; other site 909946007941 GTP/Mg2+ binding site [chemical binding]; other site 909946007942 Switch I region; other site 909946007943 G2 box; other site 909946007944 Switch II region; other site 909946007945 G3 box; other site 909946007946 G4 box; other site 909946007947 G5 box; other site 909946007948 KH domain; Region: KH_2; pfam07650 909946007949 ribonuclease III; Reviewed; Region: rnc; PRK00102 909946007950 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 909946007951 dimerization interface [polypeptide binding]; other site 909946007952 active site 909946007953 metal binding site [ion binding]; metal-binding site 909946007954 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 909946007955 dsRNA binding site [nucleotide binding]; other site 909946007956 signal peptidase I; Provisional; Region: PRK10861 909946007957 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 909946007958 Catalytic site [active] 909946007959 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 909946007960 GTP-binding protein LepA; Provisional; Region: PRK05433 909946007961 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 909946007962 G1 box; other site 909946007963 putative GEF interaction site [polypeptide binding]; other site 909946007964 GTP/Mg2+ binding site [chemical binding]; other site 909946007965 Switch I region; other site 909946007966 G2 box; other site 909946007967 G3 box; other site 909946007968 Switch II region; other site 909946007969 G4 box; other site 909946007970 G5 box; other site 909946007971 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 909946007972 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 909946007973 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 909946007974 type III secretion protein GogB; Provisional; Region: PRK15386 909946007975 Integrase core domain; Region: rve_3; cl15866 909946007976 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 909946007977 Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900 909946007978 ADP-ribose binding site [chemical binding]; other site 909946007979 putative active site [active] 909946007980 dimer interface [polypeptide binding]; other site 909946007981 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 909946007982 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 909946007983 Phage Tail Collar Domain; Region: Collar; pfam07484 909946007984 Phage-related protein, tail component [Function unknown]; Region: COG4733 909946007985 Putative phage tail protein; Region: Phage-tail_3; pfam13550 909946007986 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 909946007987 Interdomain contacts; other site 909946007988 Cytokine receptor motif; other site 909946007989 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 909946007990 Fibronectin type III protein; Region: DUF3672; pfam12421 909946007991 Phage-related protein, tail component [Function unknown]; Region: COG4723 909946007992 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 909946007993 MPN+ (JAMM) motif; other site 909946007994 Zinc-binding site [ion binding]; other site 909946007995 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 909946007996 NlpC/P60 family; Region: NLPC_P60; cl17555 909946007997 Phage-related protein [Function unknown]; Region: gp18; COG4672 909946007998 Phage-related protein [Function unknown]; Region: COG4718 909946007999 Phage-related minor tail protein [Function unknown]; Region: COG5281 909946008000 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 909946008001 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 909946008002 Minor tail protein T; Region: Phage_tail_T; pfam06223 909946008003 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 909946008004 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 909946008005 Phage tail protein; Region: Phage_tail_3; pfam08813 909946008006 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 909946008007 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 909946008008 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 909946008009 Probable transposase; Region: OrfB_IS605; pfam01385 909946008010 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 909946008011 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 909946008012 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 909946008013 DNA packaging protein FI; Region: Packaging_FI; pfam14000 909946008014 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 909946008015 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 909946008016 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 909946008017 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 909946008018 tandem repeat interface [polypeptide binding]; other site 909946008019 oligomer interface [polypeptide binding]; other site 909946008020 active site residues [active] 909946008021 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 909946008022 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 909946008023 gpW; Region: gpW; pfam02831 909946008024 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 909946008025 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 909946008026 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 909946008027 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 909946008028 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 909946008029 catalytic residues [active] 909946008030 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 909946008031 PipA protein; Region: PipA; pfam07108 909946008032 ORF6N domain; Region: ORF6N; pfam10543 909946008033 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 909946008034 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 909946008035 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 909946008036 DinI-like family; Region: DinI; pfam06183 909946008037 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 909946008038 Protein of unknown function (DUF550); Region: DUF550; pfam04447 909946008039 Protein of unknown function (DUF551); Region: DUF551; pfam04448 909946008040 Methyltransferase domain; Region: Methyltransf_25; pfam13649 909946008041 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 909946008042 Replication protein P; Region: Phage_lambda_P; pfam06992 909946008043 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 909946008044 Bacteriophage CII protein; Region: Phage_CII; pfam05269 909946008045 transcriptional repressor DicA; Reviewed; Region: PRK09706 909946008046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946008047 non-specific DNA binding site [nucleotide binding]; other site 909946008048 sequence-specific DNA binding site [nucleotide binding]; other site 909946008049 salt bridge; other site 909946008050 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 909946008051 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 909946008052 P-loop; other site 909946008053 Magnesium ion binding site [ion binding]; other site 909946008054 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 909946008055 Magnesium ion binding site [ion binding]; other site 909946008056 exonuclease VIII; Reviewed; Region: PRK09709 909946008057 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 909946008058 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 909946008059 RecT family; Region: RecT; pfam03837 909946008060 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 909946008061 integrase; Provisional; Region: PRK09692 909946008062 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 909946008063 active site 909946008064 Int/Topo IB signature motif; other site 909946008065 SoxR reducing system protein RseC; Provisional; Region: PRK10862 909946008066 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 909946008067 anti-sigma E factor; Provisional; Region: rseB; PRK09455 909946008068 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 909946008069 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 909946008070 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 909946008071 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 909946008072 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 909946008073 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 909946008074 DNA binding residues [nucleotide binding] 909946008075 L-aspartate oxidase; Provisional; Region: PRK09077 909946008076 L-aspartate oxidase; Provisional; Region: PRK06175 909946008077 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 909946008078 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 909946008079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946008080 S-adenosylmethionine binding site [chemical binding]; other site 909946008081 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 909946008082 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 909946008083 ATP binding site [chemical binding]; other site 909946008084 Mg++ binding site [ion binding]; other site 909946008085 motif III; other site 909946008086 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946008087 nucleotide binding region [chemical binding]; other site 909946008088 ATP-binding site [chemical binding]; other site 909946008089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946008090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946008091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 909946008092 dimerization interface [polypeptide binding]; other site 909946008093 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 909946008094 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 909946008095 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 909946008096 ligand binding site [chemical binding]; other site 909946008097 active site 909946008098 UGI interface [polypeptide binding]; other site 909946008099 catalytic site [active] 909946008100 putative methyltransferase; Provisional; Region: PRK10864 909946008101 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 909946008102 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 909946008103 thioredoxin 2; Provisional; Region: PRK10996 909946008104 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 909946008105 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 909946008106 catalytic residues [active] 909946008107 Uncharacterized conserved protein [Function unknown]; Region: COG3148 909946008108 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 909946008109 CoA binding domain; Region: CoA_binding_2; pfam13380 909946008110 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 909946008111 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 909946008112 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 909946008113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946008114 Coenzyme A binding pocket [chemical binding]; other site 909946008115 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 909946008116 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 909946008117 domain interface [polypeptide binding]; other site 909946008118 putative active site [active] 909946008119 catalytic site [active] 909946008120 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 909946008121 domain interface [polypeptide binding]; other site 909946008122 putative active site [active] 909946008123 catalytic site [active] 909946008124 lipoprotein; Provisional; Region: PRK10759 909946008125 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 909946008126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946008127 putative substrate translocation pore; other site 909946008128 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 909946008129 protein disaggregation chaperone; Provisional; Region: PRK10865 909946008130 Clp amino terminal domain; Region: Clp_N; pfam02861 909946008131 Clp amino terminal domain; Region: Clp_N; pfam02861 909946008132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946008133 Walker A motif; other site 909946008134 ATP binding site [chemical binding]; other site 909946008135 Walker B motif; other site 909946008136 arginine finger; other site 909946008137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946008138 Walker A motif; other site 909946008139 ATP binding site [chemical binding]; other site 909946008140 Walker B motif; other site 909946008141 arginine finger; other site 909946008142 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 909946008143 hypothetical protein; Provisional; Region: PRK10723 909946008144 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 909946008145 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 909946008146 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909946008147 RNA binding surface [nucleotide binding]; other site 909946008148 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 909946008149 active site 909946008150 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 909946008151 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 909946008152 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 909946008153 30S subunit binding site; other site 909946008154 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 909946008155 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 909946008156 Prephenate dehydratase; Region: PDT; pfam00800 909946008157 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 909946008158 putative L-Phe binding site [chemical binding]; other site 909946008159 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 909946008160 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 909946008161 Chorismate mutase type II; Region: CM_2; cl00693 909946008162 prephenate dehydrogenase; Validated; Region: PRK08507 909946008163 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 909946008164 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 909946008165 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 909946008166 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 909946008167 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 909946008168 metal binding site [ion binding]; metal-binding site 909946008169 active site 909946008170 I-site; other site 909946008171 integrase; Provisional; Region: int; PHA02601 909946008172 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 909946008173 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 909946008174 active site 909946008175 DNA binding site [nucleotide binding] 909946008176 Int/Topo IB signature motif; other site 909946008177 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 909946008178 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 909946008179 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 909946008180 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 909946008181 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 909946008182 DksA-like zinc finger domain containing protein; Region: PHA00080 909946008183 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 909946008184 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 909946008185 tail protein; Provisional; Region: D; PHA02561 909946008186 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 909946008187 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 909946008188 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 909946008189 RimM N-terminal domain; Region: RimM; pfam01782 909946008190 PRC-barrel domain; Region: PRC; pfam05239 909946008191 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 909946008192 signal recognition particle protein; Provisional; Region: PRK10867 909946008193 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 909946008194 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 909946008195 P loop; other site 909946008196 GTP binding site [chemical binding]; other site 909946008197 Signal peptide binding domain; Region: SRP_SPB; pfam02978 909946008198 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 909946008199 hypothetical protein; Provisional; Region: PRK11573 909946008200 Domain of unknown function DUF21; Region: DUF21; pfam01595 909946008201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 909946008202 Transporter associated domain; Region: CorC_HlyC; smart01091 909946008203 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 909946008204 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 909946008205 dimer interface [polypeptide binding]; other site 909946008206 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 909946008207 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 909946008208 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 909946008209 recombination and repair protein; Provisional; Region: PRK10869 909946008210 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 909946008211 Walker A/P-loop; other site 909946008212 ATP binding site [chemical binding]; other site 909946008213 Q-loop/lid; other site 909946008214 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 909946008215 ABC transporter signature motif; other site 909946008216 Walker B; other site 909946008217 D-loop; other site 909946008218 H-loop/switch region; other site 909946008219 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 909946008220 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 909946008221 hypothetical protein; Validated; Region: PRK01777 909946008222 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 909946008223 putative coenzyme Q binding site [chemical binding]; other site 909946008224 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 909946008225 SmpB-tmRNA interface; other site 909946008226 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008227 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008228 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008229 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008230 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008231 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008232 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008233 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008234 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008235 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008236 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008237 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 909946008238 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008239 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008240 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 909946008241 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008242 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946008243 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 909946008244 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 909946008245 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 909946008246 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909946008247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946008248 Walker A/P-loop; other site 909946008249 ATP binding site [chemical binding]; other site 909946008250 Q-loop/lid; other site 909946008251 ABC transporter signature motif; other site 909946008252 Walker B; other site 909946008253 D-loop; other site 909946008254 H-loop/switch region; other site 909946008255 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 909946008256 HlyD family secretion protein; Region: HlyD_3; pfam13437 909946008257 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 909946008258 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 909946008259 tail protein; Provisional; Region: D; PHA02561 909946008260 Phage protein U [General function prediction only]; Region: COG3499 909946008261 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 909946008262 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 909946008263 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 909946008264 major tail tube protein; Provisional; Region: FII; PHA02600 909946008265 major tail sheath protein; Provisional; Region: FI; PHA02560 909946008266 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 909946008267 type III secretion protein SopE; Provisional; Region: PRK15279 909946008268 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 909946008269 SopE GEF domain; Region: SopE_GEF; pfam07487 909946008270 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 909946008271 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 909946008272 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 909946008273 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 909946008274 baseplate assembly protein; Provisional; Region: J; PHA02568 909946008275 baseplate wedge subunit; Provisional; Region: W; PHA02516 909946008276 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 909946008277 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 909946008278 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 909946008279 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 909946008280 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 909946008281 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 909946008282 catalytic residues [active] 909946008283 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 909946008284 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 909946008285 terminase endonuclease subunit; Provisional; Region: M; PHA02537 909946008286 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 909946008287 capsid protein; Provisional; Region: N; PHA02538 909946008288 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 909946008289 terminase ATPase subunit; Provisional; Region: P; PHA02535 909946008290 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 909946008291 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 909946008292 portal vertex protein; Provisional; Region: Q; PHA02536 909946008293 Phage portal protein; Region: Phage_portal; pfam04860 909946008294 DNA protecting protein DprA; Region: dprA; TIGR00732 909946008295 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 909946008296 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 909946008297 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909946008298 active site 909946008299 DinI-like family; Region: DinI; pfam06183 909946008300 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 909946008301 DNA adenine methylase (dam); Region: dam; TIGR00571 909946008302 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 909946008303 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 909946008304 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 909946008305 Predicted transcriptional regulator [Transcription]; Region: COG2932 909946008306 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 909946008307 integrase; Provisional; Region: int; PHA02601 909946008308 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 909946008309 dimer interface [polypeptide binding]; other site 909946008310 active site 909946008311 catalytic residues [active] 909946008312 Int/Topo IB signature motif; other site 909946008313 GrpE; Region: GrpE; pfam01025 909946008314 integrase; Provisional; Region: PRK09692 909946008315 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 909946008316 active site 909946008317 Int/Topo IB signature motif; other site 909946008318 Predicted ATPase [General function prediction only]; Region: COG5293 909946008319 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 909946008320 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 909946008321 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 909946008322 Ash protein family; Region: Phage_ASH; pfam10554 909946008323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 909946008324 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 909946008325 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 909946008326 active site 909946008327 metal binding site [ion binding]; metal-binding site 909946008328 interdomain interaction site; other site 909946008329 D5 N terminal like; Region: D5_N; smart00885 909946008330 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 909946008331 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 909946008332 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 909946008333 active site 909946008334 Int/Topo IB signature motif; other site 909946008335 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 909946008336 SEC-C motif; Region: SEC-C; pfam02810 909946008337 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 909946008338 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 909946008339 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 909946008340 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 909946008341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946008342 non-specific DNA binding site [nucleotide binding]; other site 909946008343 salt bridge; other site 909946008344 sequence-specific DNA binding site [nucleotide binding]; other site 909946008345 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 909946008346 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 909946008347 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 909946008348 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 909946008349 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 909946008350 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 909946008351 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 909946008352 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909946008353 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909946008354 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 909946008355 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 909946008356 active site 909946008357 dimer interface [polypeptide binding]; other site 909946008358 magnesium binding site [ion binding]; other site 909946008359 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 909946008360 tetramer interface [polypeptide binding]; other site 909946008361 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 909946008362 active site 909946008363 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 909946008364 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 909946008365 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 909946008366 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 909946008367 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 909946008368 active site turn [active] 909946008369 phosphorylation site [posttranslational modification] 909946008370 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 909946008371 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 909946008372 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 909946008373 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 909946008374 Integrase; Region: Integrase_1; pfam12835 909946008375 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 909946008376 DNA-binding interface [nucleotide binding]; DNA binding site 909946008377 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 909946008378 Family description; Region: UvrD_C_2; pfam13538 909946008379 Transposase; Region: HTH_Tnp_1; cl17663 909946008380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 909946008381 putative transposase OrfB; Reviewed; Region: PHA02517 909946008382 HTH-like domain; Region: HTH_21; pfam13276 909946008383 Integrase core domain; Region: rve; pfam00665 909946008384 Integrase core domain; Region: rve_2; pfam13333 909946008385 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 909946008386 flagellin; Validated; Region: PRK08026 909946008387 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 909946008388 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 909946008389 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 909946008390 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 909946008391 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 909946008392 catalytic residues [active] 909946008393 catalytic nucleophile [active] 909946008394 Presynaptic Site I dimer interface [polypeptide binding]; other site 909946008395 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 909946008396 Synaptic Flat tetramer interface [polypeptide binding]; other site 909946008397 Synaptic Site I dimer interface [polypeptide binding]; other site 909946008398 DNA binding site [nucleotide binding] 909946008399 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 909946008400 DNA-binding interface [nucleotide binding]; DNA binding site 909946008401 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 909946008402 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 909946008403 homodimer interface [polypeptide binding]; other site 909946008404 active site 909946008405 TDP-binding site; other site 909946008406 acceptor substrate-binding pocket; other site 909946008407 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909946008408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946008409 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 909946008410 Walker A/P-loop; other site 909946008411 ATP binding site [chemical binding]; other site 909946008412 Q-loop/lid; other site 909946008413 ABC transporter signature motif; other site 909946008414 Walker B; other site 909946008415 D-loop; other site 909946008416 H-loop/switch region; other site 909946008417 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 909946008418 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909946008419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946008420 Walker A/P-loop; other site 909946008421 ATP binding site [chemical binding]; other site 909946008422 Q-loop/lid; other site 909946008423 ABC transporter signature motif; other site 909946008424 Walker B; other site 909946008425 D-loop; other site 909946008426 H-loop/switch region; other site 909946008427 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 909946008428 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 909946008429 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 909946008430 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 909946008431 outer membrane receptor FepA; Provisional; Region: PRK13528 909946008432 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 909946008433 N-terminal plug; other site 909946008434 ligand-binding site [chemical binding]; other site 909946008435 secreted effector protein PipB2; Provisional; Region: PRK15196 909946008436 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 909946008437 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 909946008438 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 909946008439 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 909946008440 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 909946008441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 909946008442 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 909946008443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 909946008444 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 909946008445 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 909946008446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 909946008447 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 909946008448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946008449 dimer interface [polypeptide binding]; other site 909946008450 phosphorylation site [posttranslational modification] 909946008451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946008452 ATP binding site [chemical binding]; other site 909946008453 Mg2+ binding site [ion binding]; other site 909946008454 G-X-G motif; other site 909946008455 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 909946008456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946008457 active site 909946008458 phosphorylation site [posttranslational modification] 909946008459 intermolecular recognition site; other site 909946008460 dimerization interface [polypeptide binding]; other site 909946008461 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946008462 DNA binding site [nucleotide binding] 909946008463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 909946008464 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 909946008465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 909946008466 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 909946008467 substrate binding pocket [chemical binding]; other site 909946008468 active site 909946008469 iron coordination sites [ion binding]; other site 909946008470 Predicted dehydrogenase [General function prediction only]; Region: COG0579 909946008471 hydroxyglutarate oxidase; Provisional; Region: PRK11728 909946008472 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 909946008473 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 909946008474 tetramerization interface [polypeptide binding]; other site 909946008475 NAD(P) binding site [chemical binding]; other site 909946008476 catalytic residues [active] 909946008477 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 909946008478 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 909946008479 inhibitor-cofactor binding pocket; inhibition site 909946008480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946008481 catalytic residue [active] 909946008482 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 909946008483 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 909946008484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946008485 DNA-binding site [nucleotide binding]; DNA binding site 909946008486 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 909946008487 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 909946008488 bacterial OsmY and nodulation domain; Region: BON; smart00749 909946008489 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 909946008490 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 909946008491 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909946008492 dimerization interface [polypeptide binding]; other site 909946008493 putative DNA binding site [nucleotide binding]; other site 909946008494 Transcriptional regulators [Transcription]; Region: MarR; COG1846 909946008495 putative Zn2+ binding site [ion binding]; other site 909946008496 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 909946008497 active site residue [active] 909946008498 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 909946008499 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 909946008500 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 909946008501 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 909946008502 hypothetical protein; Provisional; Region: PRK10556 909946008503 hypothetical protein; Provisional; Region: PRK10132 909946008504 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 909946008505 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946008506 DNA-binding site [nucleotide binding]; DNA binding site 909946008507 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909946008508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946008509 homodimer interface [polypeptide binding]; other site 909946008510 catalytic residue [active] 909946008511 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 909946008512 Uncharacterized conserved protein [Function unknown]; Region: COG2128 909946008513 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 909946008514 catalytic residues [active] 909946008515 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 909946008516 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 909946008517 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 909946008518 Class I ribonucleotide reductase; Region: RNR_I; cd01679 909946008519 active site 909946008520 dimer interface [polypeptide binding]; other site 909946008521 catalytic residues [active] 909946008522 effector binding site; other site 909946008523 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 909946008524 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 909946008525 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 909946008526 dimer interface [polypeptide binding]; other site 909946008527 putative radical transfer pathway; other site 909946008528 diiron center [ion binding]; other site 909946008529 tyrosyl radical; other site 909946008530 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 909946008531 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 909946008532 Walker A/P-loop; other site 909946008533 ATP binding site [chemical binding]; other site 909946008534 Q-loop/lid; other site 909946008535 ABC transporter signature motif; other site 909946008536 Walker B; other site 909946008537 D-loop; other site 909946008538 H-loop/switch region; other site 909946008539 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 909946008540 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 909946008541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946008542 dimer interface [polypeptide binding]; other site 909946008543 conserved gate region; other site 909946008544 putative PBP binding loops; other site 909946008545 ABC-ATPase subunit interface; other site 909946008546 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 909946008547 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 909946008548 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 909946008549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946008550 transcriptional repressor MprA; Provisional; Region: PRK10870 909946008551 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 909946008552 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 909946008553 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 909946008554 HlyD family secretion protein; Region: HlyD_3; pfam13437 909946008555 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 909946008556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946008557 putative substrate translocation pore; other site 909946008558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946008559 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 909946008560 S-ribosylhomocysteinase; Provisional; Region: PRK02260 909946008561 glutamate--cysteine ligase; Provisional; Region: PRK02107 909946008562 Predicted membrane protein [Function unknown]; Region: COG1238 909946008563 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 909946008564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946008565 motif II; other site 909946008566 carbon storage regulator; Provisional; Region: PRK01712 909946008567 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 909946008568 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 909946008569 motif 1; other site 909946008570 active site 909946008571 motif 2; other site 909946008572 motif 3; other site 909946008573 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 909946008574 DHHA1 domain; Region: DHHA1; pfam02272 909946008575 recombination regulator RecX; Reviewed; Region: recX; PRK00117 909946008576 recombinase A; Provisional; Region: recA; PRK09354 909946008577 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 909946008578 hexamer interface [polypeptide binding]; other site 909946008579 Walker A motif; other site 909946008580 ATP binding site [chemical binding]; other site 909946008581 Walker B motif; other site 909946008582 hypothetical protein; Validated; Region: PRK03661 909946008583 Transglycosylase SLT domain; Region: SLT_2; pfam13406 909946008584 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 909946008585 N-acetyl-D-glucosamine binding site [chemical binding]; other site 909946008586 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 909946008587 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 909946008588 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 909946008589 Nucleoside recognition; Region: Gate; pfam07670 909946008590 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 909946008591 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 909946008592 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 909946008593 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 909946008594 putative NAD(P) binding site [chemical binding]; other site 909946008595 active site 909946008596 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 909946008597 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 909946008598 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 909946008599 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946008600 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 909946008601 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 909946008602 putative active site [active] 909946008603 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 909946008604 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 909946008605 GAF domain; Region: GAF; pfam01590 909946008606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946008607 Walker A motif; other site 909946008608 ATP binding site [chemical binding]; other site 909946008609 Walker B motif; other site 909946008610 arginine finger; other site 909946008611 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 909946008612 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 909946008613 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 909946008614 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 909946008615 iron binding site [ion binding]; other site 909946008616 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 909946008617 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909946008618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909946008619 Acylphosphatase; Region: Acylphosphatase; pfam00708 909946008620 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 909946008621 HypF finger; Region: zf-HYPF; pfam07503 909946008622 HypF finger; Region: zf-HYPF; pfam07503 909946008623 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 909946008624 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 909946008625 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 909946008626 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 909946008627 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 909946008628 nickel binding site [ion binding]; other site 909946008629 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 909946008630 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 909946008631 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 909946008632 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 909946008633 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 909946008634 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 909946008635 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 909946008636 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 909946008637 NADH dehydrogenase; Region: NADHdh; cl00469 909946008638 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 909946008639 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 909946008640 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 909946008641 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 909946008642 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 909946008643 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 909946008644 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 909946008645 hydrogenase assembly chaperone; Provisional; Region: PRK10409 909946008646 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 909946008647 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 909946008648 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 909946008649 dimerization interface [polypeptide binding]; other site 909946008650 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 909946008651 ATP binding site [chemical binding]; other site 909946008652 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 909946008653 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 909946008654 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 909946008655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946008656 Walker A motif; other site 909946008657 ATP binding site [chemical binding]; other site 909946008658 Walker B motif; other site 909946008659 arginine finger; other site 909946008660 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 909946008661 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 909946008662 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 909946008663 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 909946008664 metal binding site [ion binding]; metal-binding site 909946008665 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 909946008666 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 909946008667 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 909946008668 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909946008669 ABC-ATPase subunit interface; other site 909946008670 dimer interface [polypeptide binding]; other site 909946008671 putative PBP binding regions; other site 909946008672 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 909946008673 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909946008674 ABC-ATPase subunit interface; other site 909946008675 dimer interface [polypeptide binding]; other site 909946008676 putative PBP binding regions; other site 909946008677 effector protein YopJ; Provisional; Region: PRK15371 909946008678 transcriptional activator SprB; Provisional; Region: PRK15320 909946008679 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 909946008680 transcriptional regulator SirC; Provisional; Region: PRK15044 909946008681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946008682 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 909946008683 invasion protein OrgB; Provisional; Region: PRK15322 909946008684 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 909946008685 invasion protein OrgA; Provisional; Region: PRK15323 909946008686 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 909946008687 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 909946008688 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 909946008689 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 909946008690 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 909946008691 transcriptional regulator HilD; Provisional; Region: PRK15185 909946008692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946008693 invasion protein regulator; Provisional; Region: PRK12370 909946008694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946008695 DNA binding site [nucleotide binding] 909946008696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 909946008697 binding surface 909946008698 TPR motif; other site 909946008699 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 909946008700 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 909946008701 N-acetyl-D-glucosamine binding site [chemical binding]; other site 909946008702 catalytic residue [active] 909946008703 pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375 909946008704 SicP binding; Region: SicP-binding; pfam09119 909946008705 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 909946008706 switch II binding region; other site 909946008707 Rac1 P-loop interaction site [polypeptide binding]; other site 909946008708 GTP binding residues [chemical binding]; other site 909946008709 switch I binding region; other site 909946008710 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 909946008711 active site 909946008712 chaperone protein SicP; Provisional; Region: PRK15329 909946008713 putative acyl carrier protein IacP; Validated; Region: PRK08172 909946008714 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 909946008715 cell invasion protein SipD; Provisional; Region: PRK15330 909946008716 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 909946008717 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 909946008718 chaperone protein SicA; Provisional; Region: PRK15331 909946008719 Tetratricopeptide repeat; Region: TPR_3; pfam07720 909946008720 Tetratricopeptide repeat; Region: TPR_3; pfam07720 909946008721 type III secretion system protein SpaS; Validated; Region: PRK08156 909946008722 type III secretion system protein SpaR; Provisional; Region: PRK15332 909946008723 type III secretion system protein SpaQ; Provisional; Region: PRK15333 909946008724 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 909946008725 type III secretion system protein SpaO; Validated; Region: PRK08158 909946008726 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 909946008727 antigen presentation protein SpaN; Provisional; Region: PRK15334 909946008728 Surface presentation of antigens protein; Region: SPAN; pfam02510 909946008729 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 909946008730 ATP synthase SpaL; Validated; Region: PRK08149 909946008731 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 909946008732 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 909946008733 Walker A motif; other site 909946008734 ATP binding site [chemical binding]; other site 909946008735 Walker B motif; other site 909946008736 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 909946008737 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 909946008738 type III secretion system protein InvA; Provisional; Region: PRK15337 909946008739 type III secretion system regulator InvE; Provisional; Region: PRK15338 909946008740 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 909946008741 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 909946008742 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 909946008743 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 909946008744 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 909946008745 transcriptional regulator InvF; Provisional; Region: PRK15340 909946008746 InvH outer membrane lipoprotein; Region: InvH; pfam04741 909946008747 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 909946008748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 909946008749 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 909946008750 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 909946008751 active site 909946008752 metal binding site [ion binding]; metal-binding site 909946008753 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 909946008754 MutS domain I; Region: MutS_I; pfam01624 909946008755 MutS domain II; Region: MutS_II; pfam05188 909946008756 MutS domain III; Region: MutS_III; pfam05192 909946008757 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 909946008758 Walker A/P-loop; other site 909946008759 ATP binding site [chemical binding]; other site 909946008760 Q-loop/lid; other site 909946008761 ABC transporter signature motif; other site 909946008762 Walker B; other site 909946008763 D-loop; other site 909946008764 H-loop/switch region; other site 909946008765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 909946008766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946008767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909946008768 putative substrate translocation pore; other site 909946008769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946008770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946008771 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 909946008772 putative effector binding pocket; other site 909946008773 dimerization interface [polypeptide binding]; other site 909946008774 GntP family permease; Region: GntP_permease; pfam02447 909946008775 fructuronate transporter; Provisional; Region: PRK10034; cl15264 909946008776 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 909946008777 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 909946008778 putative NAD(P) binding site [chemical binding]; other site 909946008779 active site 909946008780 putative substrate binding site [chemical binding]; other site 909946008781 hypothetical protein; Provisional; Region: PRK09989 909946008782 putative aldolase; Validated; Region: PRK08130 909946008783 intersubunit interface [polypeptide binding]; other site 909946008784 active site 909946008785 Zn2+ binding site [ion binding]; other site 909946008786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 909946008787 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 909946008788 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 909946008789 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909946008790 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 909946008791 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946008792 MarR family; Region: MarR_2; cl17246 909946008793 Transcriptional regulators [Transcription]; Region: MarR; COG1846 909946008794 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 909946008795 Flavoprotein; Region: Flavoprotein; pfam02441 909946008796 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 909946008797 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 909946008798 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 909946008799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 909946008800 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 909946008801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 909946008802 DNA binding residues [nucleotide binding] 909946008803 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 909946008804 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 909946008805 Peptidase family M23; Region: Peptidase_M23; pfam01551 909946008806 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 909946008807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946008808 S-adenosylmethionine binding site [chemical binding]; other site 909946008809 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 909946008810 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 909946008811 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 909946008812 Permutation of conserved domain; other site 909946008813 active site 909946008814 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 909946008815 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 909946008816 homotrimer interaction site [polypeptide binding]; other site 909946008817 zinc binding site [ion binding]; other site 909946008818 CDP-binding sites; other site 909946008819 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 909946008820 substrate binding site; other site 909946008821 dimer interface; other site 909946008822 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 909946008823 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 909946008824 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 909946008825 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 909946008826 ligand-binding site [chemical binding]; other site 909946008827 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 909946008828 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 909946008829 CysD dimerization site [polypeptide binding]; other site 909946008830 G1 box; other site 909946008831 putative GEF interaction site [polypeptide binding]; other site 909946008832 GTP/Mg2+ binding site [chemical binding]; other site 909946008833 Switch I region; other site 909946008834 G2 box; other site 909946008835 G3 box; other site 909946008836 Switch II region; other site 909946008837 G4 box; other site 909946008838 G5 box; other site 909946008839 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 909946008840 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 909946008841 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 909946008842 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 909946008843 Active Sites [active] 909946008844 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 909946008845 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 909946008846 metal binding site [ion binding]; metal-binding site 909946008847 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 909946008848 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 909946008849 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 909946008850 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 909946008851 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 909946008852 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 909946008853 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 909946008854 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 909946008855 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 909946008856 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 909946008857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 909946008858 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 909946008859 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 909946008860 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 909946008861 Active Sites [active] 909946008862 sulfite reductase subunit beta; Provisional; Region: PRK13504 909946008863 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 909946008864 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 909946008865 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 909946008866 Flavodoxin; Region: Flavodoxin_1; pfam00258 909946008867 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 909946008868 FAD binding pocket [chemical binding]; other site 909946008869 FAD binding motif [chemical binding]; other site 909946008870 catalytic residues [active] 909946008871 NAD binding pocket [chemical binding]; other site 909946008872 phosphate binding motif [ion binding]; other site 909946008873 beta-alpha-beta structure motif; other site 909946008874 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 909946008875 active site 909946008876 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 909946008877 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 909946008878 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 909946008879 enolase; Provisional; Region: eno; PRK00077 909946008880 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 909946008881 dimer interface [polypeptide binding]; other site 909946008882 metal binding site [ion binding]; metal-binding site 909946008883 substrate binding pocket [chemical binding]; other site 909946008884 CTP synthetase; Validated; Region: pyrG; PRK05380 909946008885 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 909946008886 Catalytic site [active] 909946008887 active site 909946008888 UTP binding site [chemical binding]; other site 909946008889 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 909946008890 active site 909946008891 putative oxyanion hole; other site 909946008892 catalytic triad [active] 909946008893 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 909946008894 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 909946008895 homodimer interface [polypeptide binding]; other site 909946008896 metal binding site [ion binding]; metal-binding site 909946008897 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 909946008898 homodimer interface [polypeptide binding]; other site 909946008899 active site 909946008900 putative chemical substrate binding site [chemical binding]; other site 909946008901 metal binding site [ion binding]; metal-binding site 909946008902 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 909946008903 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 909946008904 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 909946008905 HD domain; Region: HD_4; pfam13328 909946008906 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 909946008907 synthetase active site [active] 909946008908 NTP binding site [chemical binding]; other site 909946008909 metal binding site [ion binding]; metal-binding site 909946008910 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 909946008911 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 909946008912 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 909946008913 TRAM domain; Region: TRAM; pfam01938 909946008914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946008915 S-adenosylmethionine binding site [chemical binding]; other site 909946008916 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 909946008917 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 909946008918 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946008919 dimerization interface [polypeptide binding]; other site 909946008920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946008921 dimer interface [polypeptide binding]; other site 909946008922 phosphorylation site [posttranslational modification] 909946008923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946008924 ATP binding site [chemical binding]; other site 909946008925 Mg2+ binding site [ion binding]; other site 909946008926 G-X-G motif; other site 909946008927 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 909946008928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946008929 active site 909946008930 phosphorylation site [posttranslational modification] 909946008931 intermolecular recognition site; other site 909946008932 dimerization interface [polypeptide binding]; other site 909946008933 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 909946008934 putative binding surface; other site 909946008935 active site 909946008936 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 909946008937 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 909946008938 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 909946008939 active site 909946008940 tetramer interface [polypeptide binding]; other site 909946008941 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 909946008942 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 909946008943 active site 909946008944 tetramer interface [polypeptide binding]; other site 909946008945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946008946 D-galactonate transporter; Region: 2A0114; TIGR00893 909946008947 putative substrate translocation pore; other site 909946008948 flavodoxin; Provisional; Region: PRK08105 909946008949 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 909946008950 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 909946008951 probable active site [active] 909946008952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 909946008953 SecY interacting protein Syd; Provisional; Region: PRK04968 909946008954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 909946008955 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 909946008956 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 909946008957 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 909946008958 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 909946008959 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 909946008960 serine transporter; Region: stp; TIGR00814 909946008961 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 909946008962 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 909946008963 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 909946008964 flap endonuclease-like protein; Provisional; Region: PRK09482 909946008965 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 909946008966 active site 909946008967 metal binding site 1 [ion binding]; metal-binding site 909946008968 putative 5' ssDNA interaction site; other site 909946008969 metal binding site 3; metal-binding site 909946008970 metal binding site 2 [ion binding]; metal-binding site 909946008971 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 909946008972 putative DNA binding site [nucleotide binding]; other site 909946008973 putative metal binding site [ion binding]; other site 909946008974 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 909946008975 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 909946008976 dimer interface [polypeptide binding]; other site 909946008977 active site 909946008978 metal binding site [ion binding]; metal-binding site 909946008979 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 909946008980 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 909946008981 intersubunit interface [polypeptide binding]; other site 909946008982 active site 909946008983 Zn2+ binding site [ion binding]; other site 909946008984 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 909946008985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946008986 putative substrate translocation pore; other site 909946008987 L-fucose isomerase; Provisional; Region: fucI; PRK10991 909946008988 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 909946008989 hexamer (dimer of trimers) interface [polypeptide binding]; other site 909946008990 trimer interface [polypeptide binding]; other site 909946008991 substrate binding site [chemical binding]; other site 909946008992 Mn binding site [ion binding]; other site 909946008993 L-fuculokinase; Provisional; Region: PRK10331 909946008994 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 909946008995 nucleotide binding site [chemical binding]; other site 909946008996 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 909946008997 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 909946008998 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 909946008999 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946009000 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 909946009001 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 909946009002 hypothetical protein; Provisional; Region: PRK10873 909946009003 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 909946009004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946009005 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 909946009006 dimerization interface [polypeptide binding]; other site 909946009007 substrate binding pocket [chemical binding]; other site 909946009008 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 909946009009 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 909946009010 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 909946009011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909946009012 catalytic residue [active] 909946009013 CsdA-binding activator; Provisional; Region: PRK15019 909946009014 Predicted permeases [General function prediction only]; Region: RarD; COG2962 909946009015 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 909946009016 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 909946009017 putative ATP binding site [chemical binding]; other site 909946009018 putative substrate interface [chemical binding]; other site 909946009019 murein transglycosylase A; Provisional; Region: mltA; PRK11162 909946009020 murein hydrolase B; Provisional; Region: PRK10760; cl17906 909946009021 MltA specific insert domain; Region: MltA; pfam03562 909946009022 3D domain; Region: 3D; pfam06725 909946009023 AMIN domain; Region: AMIN; pfam11741 909946009024 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 909946009025 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 909946009026 active site 909946009027 metal binding site [ion binding]; metal-binding site 909946009028 N-acetylglutamate synthase; Validated; Region: PRK05279 909946009029 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 909946009030 putative feedback inhibition sensing region; other site 909946009031 putative nucleotide binding site [chemical binding]; other site 909946009032 putative substrate binding site [chemical binding]; other site 909946009033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946009034 Coenzyme A binding pocket [chemical binding]; other site 909946009035 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 909946009036 AAA domain; Region: AAA_30; pfam13604 909946009037 Family description; Region: UvrD_C_2; pfam13538 909946009038 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 909946009039 protease3; Provisional; Region: PRK15101 909946009040 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 909946009041 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 909946009042 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 909946009043 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 909946009044 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 909946009045 hypothetical protein; Provisional; Region: PRK10332 909946009046 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 909946009047 hypothetical protein; Provisional; Region: PRK11521 909946009048 hypothetical protein; Provisional; Region: PRK10557 909946009049 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 909946009050 hypothetical protein; Provisional; Region: PRK10506 909946009051 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 909946009052 thymidylate synthase; Reviewed; Region: thyA; PRK01827 909946009053 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 909946009054 dimerization interface [polypeptide binding]; other site 909946009055 active site 909946009056 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 909946009057 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 909946009058 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 909946009059 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 909946009060 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 909946009061 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 909946009062 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 909946009063 putative active site [active] 909946009064 Ap4A binding site [chemical binding]; other site 909946009065 nudix motif; other site 909946009066 putative metal binding site [ion binding]; other site 909946009067 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 909946009068 putative DNA-binding cleft [nucleotide binding]; other site 909946009069 putative DNA clevage site; other site 909946009070 molecular lever; other site 909946009071 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 909946009072 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 909946009073 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909946009074 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909946009075 active site 909946009076 catalytic tetrad [active] 909946009077 lysophospholipid transporter LplT; Provisional; Region: PRK11195 909946009078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946009079 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 909946009080 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 909946009081 putative acyl-acceptor binding pocket; other site 909946009082 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 909946009083 acyl-activating enzyme (AAE) consensus motif; other site 909946009084 putative AMP binding site [chemical binding]; other site 909946009085 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 909946009086 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946009087 DNA binding site [nucleotide binding] 909946009088 domain linker motif; other site 909946009089 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 909946009090 dimerization interface (closed form) [polypeptide binding]; other site 909946009091 ligand binding site [chemical binding]; other site 909946009092 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909946009093 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946009094 DNA binding site [nucleotide binding] 909946009095 domain linker motif; other site 909946009096 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 909946009097 dimerization interface (closed form) [polypeptide binding]; other site 909946009098 ligand binding site [chemical binding]; other site 909946009099 diaminopimelate decarboxylase; Provisional; Region: PRK11165 909946009100 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 909946009101 active site 909946009102 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 909946009103 substrate binding site [chemical binding]; other site 909946009104 catalytic residues [active] 909946009105 dimer interface [polypeptide binding]; other site 909946009106 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 909946009107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946009108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 909946009109 dimerization interface [polypeptide binding]; other site 909946009110 putative racemase; Provisional; Region: PRK10200 909946009111 aspartate racemase; Region: asp_race; TIGR00035 909946009112 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 909946009113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946009114 putative substrate translocation pore; other site 909946009115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946009116 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 909946009117 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 909946009118 NADP binding site [chemical binding]; other site 909946009119 homodimer interface [polypeptide binding]; other site 909946009120 active site 909946009121 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 909946009122 putative acyltransferase; Provisional; Region: PRK05790 909946009123 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 909946009124 dimer interface [polypeptide binding]; other site 909946009125 active site 909946009126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946009127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946009128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 909946009129 dimerization interface [polypeptide binding]; other site 909946009130 Predicted membrane protein [Function unknown]; Region: COG4125 909946009131 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 909946009132 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 909946009133 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 909946009134 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 909946009135 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 909946009136 putative metal binding site [ion binding]; other site 909946009137 putative homodimer interface [polypeptide binding]; other site 909946009138 putative homotetramer interface [polypeptide binding]; other site 909946009139 putative homodimer-homodimer interface [polypeptide binding]; other site 909946009140 putative allosteric switch controlling residues; other site 909946009141 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 909946009142 transcriptional activator SprB; Provisional; Region: PRK15320 909946009143 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 909946009144 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 909946009145 Fimbrial protein; Region: Fimbrial; pfam00419 909946009146 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 909946009147 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946009148 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946009149 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 909946009150 PapC N-terminal domain; Region: PapC_N; pfam13954 909946009151 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 909946009152 PapC C-terminal domain; Region: PapC_C; pfam13953 909946009153 fimbrial protein StdA; Provisional; Region: PRK15210 909946009154 hypothetical protein; Provisional; Region: PRK10316 909946009155 YfdX protein; Region: YfdX; pfam10938 909946009156 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 909946009157 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 909946009158 oligomeric interface; other site 909946009159 putative active site [active] 909946009160 homodimer interface [polypeptide binding]; other site 909946009161 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 909946009162 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 909946009163 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 909946009164 Peptidase family M23; Region: Peptidase_M23; pfam01551 909946009165 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 909946009166 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 909946009167 active site 909946009168 metal binding site [ion binding]; metal-binding site 909946009169 nudix motif; other site 909946009170 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 909946009171 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 909946009172 dimer interface [polypeptide binding]; other site 909946009173 putative anticodon binding site; other site 909946009174 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 909946009175 motif 1; other site 909946009176 active site 909946009177 motif 2; other site 909946009178 motif 3; other site 909946009179 peptide chain release factor 2; Validated; Region: prfB; PRK00578 909946009180 This domain is found in peptide chain release factors; Region: PCRF; smart00937 909946009181 RF-1 domain; Region: RF-1; pfam00472 909946009182 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 909946009183 DHH family; Region: DHH; pfam01368 909946009184 DHHA1 domain; Region: DHHA1; pfam02272 909946009185 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 909946009186 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 909946009187 dimerization domain [polypeptide binding]; other site 909946009188 dimer interface [polypeptide binding]; other site 909946009189 catalytic residues [active] 909946009190 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 909946009191 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 909946009192 active site 909946009193 Int/Topo IB signature motif; other site 909946009194 flavodoxin FldB; Provisional; Region: PRK12359 909946009195 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 909946009196 hypothetical protein; Provisional; Region: PRK10878 909946009197 putative global regulator; Reviewed; Region: PRK09559 909946009198 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 909946009199 hemolysin; Provisional; Region: PRK15087 909946009200 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 909946009201 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 909946009202 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 909946009203 beta-galactosidase; Region: BGL; TIGR03356 909946009204 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 909946009205 glycine dehydrogenase; Provisional; Region: PRK05367 909946009206 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 909946009207 tetramer interface [polypeptide binding]; other site 909946009208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946009209 catalytic residue [active] 909946009210 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 909946009211 tetramer interface [polypeptide binding]; other site 909946009212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946009213 catalytic residue [active] 909946009214 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 909946009215 lipoyl attachment site [posttranslational modification]; other site 909946009216 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 909946009217 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 909946009218 oxidoreductase; Provisional; Region: PRK08013 909946009219 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 909946009220 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 909946009221 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 909946009222 proline aminopeptidase P II; Provisional; Region: PRK10879 909946009223 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 909946009224 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 909946009225 active site 909946009226 hypothetical protein; Reviewed; Region: PRK01736 909946009227 Z-ring-associated protein; Provisional; Region: PRK10972 909946009228 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 909946009229 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 909946009230 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 909946009231 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 909946009232 ligand binding site [chemical binding]; other site 909946009233 NAD binding site [chemical binding]; other site 909946009234 tetramer interface [polypeptide binding]; other site 909946009235 catalytic site [active] 909946009236 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 909946009237 L-serine binding site [chemical binding]; other site 909946009238 ACT domain interface; other site 909946009239 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 909946009240 tetramer (dimer of dimers) interface [polypeptide binding]; other site 909946009241 active site 909946009242 dimer interface [polypeptide binding]; other site 909946009243 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 909946009244 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946009245 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 909946009246 putative dimerization interface [polypeptide binding]; other site 909946009247 Uncharacterized conserved protein [Function unknown]; Region: COG2968 909946009248 oxidative stress defense protein; Provisional; Region: PRK11087 909946009249 arginine exporter protein; Provisional; Region: PRK09304 909946009250 mechanosensitive channel MscS; Provisional; Region: PRK10334 909946009251 Mechanosensitive ion channel; Region: MS_channel; pfam00924 909946009252 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 909946009253 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 909946009254 active site 909946009255 intersubunit interface [polypeptide binding]; other site 909946009256 zinc binding site [ion binding]; other site 909946009257 Na+ binding site [ion binding]; other site 909946009258 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 909946009259 Phosphoglycerate kinase; Region: PGK; pfam00162 909946009260 substrate binding site [chemical binding]; other site 909946009261 hinge regions; other site 909946009262 ADP binding site [chemical binding]; other site 909946009263 catalytic site [active] 909946009264 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 909946009265 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 909946009266 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 909946009267 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 909946009268 trimer interface [polypeptide binding]; other site 909946009269 putative Zn binding site [ion binding]; other site 909946009270 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 909946009271 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 909946009272 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 909946009273 Walker A/P-loop; other site 909946009274 ATP binding site [chemical binding]; other site 909946009275 Q-loop/lid; other site 909946009276 ABC transporter signature motif; other site 909946009277 Walker B; other site 909946009278 D-loop; other site 909946009279 H-loop/switch region; other site 909946009280 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 909946009281 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 909946009282 Walker A/P-loop; other site 909946009283 ATP binding site [chemical binding]; other site 909946009284 Q-loop/lid; other site 909946009285 ABC transporter signature motif; other site 909946009286 Walker B; other site 909946009287 D-loop; other site 909946009288 H-loop/switch region; other site 909946009289 transketolase; Reviewed; Region: PRK12753 909946009290 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 909946009291 TPP-binding site [chemical binding]; other site 909946009292 dimer interface [polypeptide binding]; other site 909946009293 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 909946009294 PYR/PP interface [polypeptide binding]; other site 909946009295 dimer interface [polypeptide binding]; other site 909946009296 TPP binding site [chemical binding]; other site 909946009297 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 909946009298 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 909946009299 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 909946009300 agmatinase; Region: agmatinase; TIGR01230 909946009301 oligomer interface [polypeptide binding]; other site 909946009302 putative active site [active] 909946009303 Mn binding site [ion binding]; other site 909946009304 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 909946009305 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 909946009306 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 909946009307 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 909946009308 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 909946009309 putative NAD(P) binding site [chemical binding]; other site 909946009310 catalytic Zn binding site [ion binding]; other site 909946009311 structural Zn binding site [ion binding]; other site 909946009312 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 909946009313 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 909946009314 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 909946009315 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 909946009316 Transcriptional regulators [Transcription]; Region: FadR; COG2186 909946009317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946009318 DNA-binding site [nucleotide binding]; DNA binding site 909946009319 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 909946009320 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 909946009321 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 909946009322 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 909946009323 dimer interface [polypeptide binding]; other site 909946009324 active site 909946009325 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 909946009326 catalytic residues [active] 909946009327 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 909946009328 Virulence promoting factor; Region: YqgB; pfam11036 909946009329 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 909946009330 S-adenosylmethionine synthetase; Validated; Region: PRK05250 909946009331 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 909946009332 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 909946009333 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 909946009334 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 909946009335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946009336 putative substrate translocation pore; other site 909946009337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946009338 hypothetical protein; Provisional; Region: PRK04860 909946009339 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 909946009340 DNA-specific endonuclease I; Provisional; Region: PRK15137 909946009341 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 909946009342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 909946009343 RNA methyltransferase, RsmE family; Region: TIGR00046 909946009344 glutathione synthetase; Provisional; Region: PRK05246 909946009345 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 909946009346 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 909946009347 hypothetical protein; Validated; Region: PRK00228 909946009348 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 909946009349 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 909946009350 Transcriptional regulator [Transcription]; Region: IclR; COG1414 909946009351 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 909946009352 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 909946009353 Walker A motif; other site 909946009354 ATP binding site [chemical binding]; other site 909946009355 Walker B motif; other site 909946009356 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 909946009357 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 909946009358 catalytic residue [active] 909946009359 YGGT family; Region: YGGT; pfam02325 909946009360 YGGT family; Region: YGGT; pfam02325 909946009361 hypothetical protein; Validated; Region: PRK05090 909946009362 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 909946009363 active site 909946009364 dimerization interface [polypeptide binding]; other site 909946009365 HemN family oxidoreductase; Provisional; Region: PRK05660 909946009366 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946009367 FeS/SAM binding site; other site 909946009368 HemN C-terminal domain; Region: HemN_C; pfam06969 909946009369 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 909946009370 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 909946009371 homodimer interface [polypeptide binding]; other site 909946009372 active site 909946009373 hypothetical protein; Provisional; Region: PRK10626 909946009374 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 909946009375 hypothetical protein; Provisional; Region: PRK11702 909946009376 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 909946009377 adenine DNA glycosylase; Provisional; Region: PRK10880 909946009378 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 909946009379 minor groove reading motif; other site 909946009380 helix-hairpin-helix signature motif; other site 909946009381 substrate binding pocket [chemical binding]; other site 909946009382 active site 909946009383 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 909946009384 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 909946009385 DNA binding and oxoG recognition site [nucleotide binding] 909946009386 oxidative damage protection protein; Provisional; Region: PRK05408 909946009387 murein transglycosylase C; Provisional; Region: mltC; PRK11671 909946009388 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 909946009389 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 909946009390 N-acetyl-D-glucosamine binding site [chemical binding]; other site 909946009391 catalytic residue [active] 909946009392 nucleoside transporter; Region: 2A0110; TIGR00889 909946009393 ornithine decarboxylase; Provisional; Region: PRK13578 909946009394 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 909946009395 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 909946009396 homodimer interface [polypeptide binding]; other site 909946009397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946009398 catalytic residue [active] 909946009399 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 909946009400 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 909946009401 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 909946009402 dimer interface [polypeptide binding]; other site 909946009403 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 909946009404 metal binding site [ion binding]; metal-binding site 909946009405 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 909946009406 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 909946009407 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 909946009408 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 909946009409 putative active site [active] 909946009410 putative catalytic site [active] 909946009411 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 909946009412 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 909946009413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946009414 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 909946009415 putative dimerization interface [polypeptide binding]; other site 909946009416 putative substrate binding pocket [chemical binding]; other site 909946009417 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 909946009418 Sulfatase; Region: Sulfatase; pfam00884 909946009419 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 909946009420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946009421 FeS/SAM binding site; other site 909946009422 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 909946009423 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 909946009424 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946009425 DNA binding residues [nucleotide binding] 909946009426 dimerization interface [polypeptide binding]; other site 909946009427 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 909946009428 Amino acid permease; Region: AA_permease_2; pfam13520 909946009429 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 909946009430 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 909946009431 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 909946009432 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 909946009433 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 909946009434 NAD(P) binding site [chemical binding]; other site 909946009435 catalytic residues [active] 909946009436 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 909946009437 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 909946009438 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 909946009439 active site 909946009440 catalytic site [active] 909946009441 Zn binding site [ion binding]; other site 909946009442 tetramer interface [polypeptide binding]; other site 909946009443 Predicted amidohydrolase [General function prediction only]; Region: COG0388 909946009444 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 909946009445 putative active site [active] 909946009446 catalytic triad [active] 909946009447 putative dimer interface [polypeptide binding]; other site 909946009448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946009449 D-galactonate transporter; Region: 2A0114; TIGR00893 909946009450 putative substrate translocation pore; other site 909946009451 mannonate dehydratase; Provisional; Region: PRK03906 909946009452 mannonate dehydratase; Region: uxuA; TIGR00695 909946009453 D-mannonate oxidoreductase; Provisional; Region: PRK15037 909946009454 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 909946009455 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 909946009456 Glucuronate isomerase; Region: UxaC; pfam02614 909946009457 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 909946009458 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 909946009459 dimer interface [polypeptide binding]; other site 909946009460 putative CheW interface [polypeptide binding]; other site 909946009461 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 909946009462 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 909946009463 CHAP domain; Region: CHAP; pfam05257 909946009464 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 909946009465 putative S-transferase; Provisional; Region: PRK11752 909946009466 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 909946009467 C-terminal domain interface [polypeptide binding]; other site 909946009468 GSH binding site (G-site) [chemical binding]; other site 909946009469 dimer interface [polypeptide binding]; other site 909946009470 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 909946009471 dimer interface [polypeptide binding]; other site 909946009472 N-terminal domain interface [polypeptide binding]; other site 909946009473 active site 909946009474 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 909946009475 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 909946009476 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 909946009477 putative ligand binding residues [chemical binding]; other site 909946009478 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 909946009479 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 909946009480 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 909946009481 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 909946009482 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 909946009483 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 909946009484 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 909946009485 putative substrate-binding site; other site 909946009486 nickel binding site [ion binding]; other site 909946009487 hydrogenase 2 large subunit; Provisional; Region: PRK10467 909946009488 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 909946009489 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 909946009490 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 909946009491 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 909946009492 4Fe-4S binding domain; Region: Fer4_6; pfam12837 909946009493 hydrogenase 2 small subunit; Provisional; Region: PRK10468 909946009494 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 909946009495 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 909946009496 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 909946009497 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 909946009498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946009499 dimerization interface [polypeptide binding]; other site 909946009500 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 909946009501 dimer interface [polypeptide binding]; other site 909946009502 putative CheW interface [polypeptide binding]; other site 909946009503 hypothetical protein; Provisional; Region: PRK05208 909946009504 oxidoreductase; Provisional; Region: PRK07985 909946009505 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 909946009506 NAD binding site [chemical binding]; other site 909946009507 metal binding site [ion binding]; metal-binding site 909946009508 active site 909946009509 biopolymer transport protein ExbD; Provisional; Region: PRK11267 909946009510 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 909946009511 biopolymer transport protein ExbB; Provisional; Region: PRK10414 909946009512 cystathionine beta-lyase; Provisional; Region: PRK08114 909946009513 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 909946009514 homodimer interface [polypeptide binding]; other site 909946009515 substrate-cofactor binding pocket; other site 909946009516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946009517 catalytic residue [active] 909946009518 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 909946009519 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 909946009520 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 909946009521 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 909946009522 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946009523 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946009524 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 909946009525 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 909946009526 dimer interface [polypeptide binding]; other site 909946009527 active site 909946009528 metal binding site [ion binding]; metal-binding site 909946009529 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909946009530 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909946009531 active site 909946009532 catalytic tetrad [active] 909946009533 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 909946009534 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 909946009535 transmembrane helices; other site 909946009536 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 909946009537 nucleotide binding site/active site [active] 909946009538 catalytic residue [active] 909946009539 hypothetical protein; Provisional; Region: PRK01254 909946009540 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 909946009541 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 909946009542 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 909946009543 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 909946009544 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 909946009545 DctM-like transporters; Region: DctM; pfam06808 909946009546 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 909946009547 FtsI repressor; Provisional; Region: PRK10883 909946009548 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 909946009549 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 909946009550 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 909946009551 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 909946009552 putative acyl-acceptor binding pocket; other site 909946009553 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 909946009554 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 909946009555 CAP-like domain; other site 909946009556 active site 909946009557 primary dimer interface [polypeptide binding]; other site 909946009558 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 909946009559 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 909946009560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946009561 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 909946009562 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 909946009563 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 909946009564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946009565 active site 909946009566 phosphorylation site [posttranslational modification] 909946009567 intermolecular recognition site; other site 909946009568 dimerization interface [polypeptide binding]; other site 909946009569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946009570 DNA binding site [nucleotide binding] 909946009571 sensor protein QseC; Provisional; Region: PRK10337 909946009572 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 909946009573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946009574 dimer interface [polypeptide binding]; other site 909946009575 phosphorylation site [posttranslational modification] 909946009576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946009577 ATP binding site [chemical binding]; other site 909946009578 Mg2+ binding site [ion binding]; other site 909946009579 G-X-G motif; other site 909946009580 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 909946009581 Uncharacterized conserved protein [Function unknown]; Region: COG1359 909946009582 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 909946009583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946009584 ATP binding site [chemical binding]; other site 909946009585 Mg2+ binding site [ion binding]; other site 909946009586 G-X-G motif; other site 909946009587 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 909946009588 anchoring element; other site 909946009589 dimer interface [polypeptide binding]; other site 909946009590 ATP binding site [chemical binding]; other site 909946009591 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 909946009592 active site 909946009593 metal binding site [ion binding]; metal-binding site 909946009594 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 909946009595 esterase YqiA; Provisional; Region: PRK11071 909946009596 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 909946009597 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 909946009598 active site 909946009599 metal binding site [ion binding]; metal-binding site 909946009600 hexamer interface [polypeptide binding]; other site 909946009601 putative dehydrogenase; Provisional; Region: PRK11039 909946009602 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 909946009603 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 909946009604 dimer interface [polypeptide binding]; other site 909946009605 ADP-ribose binding site [chemical binding]; other site 909946009606 active site 909946009607 nudix motif; other site 909946009608 metal binding site [ion binding]; metal-binding site 909946009609 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 909946009610 hypothetical protein; Provisional; Region: PRK11653 909946009611 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 909946009612 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 909946009613 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 909946009614 putative active site [active] 909946009615 metal binding site [ion binding]; metal-binding site 909946009616 zinc transporter ZupT; Provisional; Region: PRK04201 909946009617 ZIP Zinc transporter; Region: Zip; pfam02535 909946009618 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 909946009619 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 909946009620 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 909946009621 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 909946009622 catalytic residues [active] 909946009623 hinge region; other site 909946009624 alpha helical domain; other site 909946009625 putative disulfide oxidoreductase; Provisional; Region: PRK04307 909946009626 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 909946009627 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 909946009628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 909946009629 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 909946009630 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 909946009631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 909946009632 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 909946009633 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 909946009634 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 909946009635 putative ribose interaction site [chemical binding]; other site 909946009636 putative ADP binding site [chemical binding]; other site 909946009637 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 909946009638 active site 909946009639 nucleotide binding site [chemical binding]; other site 909946009640 HIGH motif; other site 909946009641 KMSKS motif; other site 909946009642 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 909946009643 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 909946009644 metal binding triad; other site 909946009645 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 909946009646 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 909946009647 metal binding triad; other site 909946009648 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 909946009649 Uncharacterized conserved protein [Function unknown]; Region: COG3025 909946009650 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 909946009651 putative active site [active] 909946009652 putative metal binding residues [ion binding]; other site 909946009653 signature motif; other site 909946009654 putative triphosphate binding site [ion binding]; other site 909946009655 CHAD domain; Region: CHAD; pfam05235 909946009656 SH3 domain-containing protein; Provisional; Region: PRK10884 909946009657 Bacterial SH3 domain homologues; Region: SH3b; smart00287 909946009658 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 909946009659 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 909946009660 active site 909946009661 NTP binding site [chemical binding]; other site 909946009662 metal binding triad [ion binding]; metal-binding site 909946009663 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 909946009664 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 909946009665 Zn2+ binding site [ion binding]; other site 909946009666 Mg2+ binding site [ion binding]; other site 909946009667 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 909946009668 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 909946009669 homooctamer interface [polypeptide binding]; other site 909946009670 active site 909946009671 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 909946009672 UGMP family protein; Validated; Region: PRK09604 909946009673 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 909946009674 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 909946009675 DNA primase; Validated; Region: dnaG; PRK05667 909946009676 CHC2 zinc finger; Region: zf-CHC2; pfam01807 909946009677 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 909946009678 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 909946009679 active site 909946009680 metal binding site [ion binding]; metal-binding site 909946009681 interdomain interaction site; other site 909946009682 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 909946009683 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 909946009684 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 909946009685 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 909946009686 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 909946009687 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 909946009688 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 909946009689 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 909946009690 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 909946009691 DNA binding residues [nucleotide binding] 909946009692 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 909946009693 active site 909946009694 SUMO-1 interface [polypeptide binding]; other site 909946009695 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 909946009696 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 909946009697 FAD binding pocket [chemical binding]; other site 909946009698 FAD binding motif [chemical binding]; other site 909946009699 phosphate binding motif [ion binding]; other site 909946009700 NAD binding pocket [chemical binding]; other site 909946009701 Predicted transcriptional regulators [Transcription]; Region: COG1695 909946009702 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 909946009703 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 909946009704 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946009705 dimerization interface [polypeptide binding]; other site 909946009706 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 909946009707 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 909946009708 dimer interface [polypeptide binding]; other site 909946009709 putative CheW interface [polypeptide binding]; other site 909946009710 PAS fold; Region: PAS_3; pfam08447 909946009711 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 909946009712 putative active site [active] 909946009713 heme pocket [chemical binding]; other site 909946009714 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 909946009715 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 909946009716 dimer interface [polypeptide binding]; other site 909946009717 putative CheW interface [polypeptide binding]; other site 909946009718 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 909946009719 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 909946009720 inhibitor-cofactor binding pocket; inhibition site 909946009721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946009722 catalytic residue [active] 909946009723 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 909946009724 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 909946009725 active site 909946009726 FMN binding site [chemical binding]; other site 909946009727 2,4-decadienoyl-CoA binding site; other site 909946009728 catalytic residue [active] 909946009729 4Fe-4S cluster binding site [ion binding]; other site 909946009730 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 909946009731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909946009732 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 909946009733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946009734 S-adenosylmethionine binding site [chemical binding]; other site 909946009735 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 909946009736 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 909946009737 putative active site [active] 909946009738 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 909946009739 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909946009740 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 909946009741 serine/threonine transporter SstT; Provisional; Region: PRK13628 909946009742 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 909946009743 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 909946009744 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 909946009745 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 909946009746 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 909946009747 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 909946009748 Predicted membrane protein [Function unknown]; Region: COG5393 909946009749 YqjK-like protein; Region: YqjK; pfam13997 909946009750 Predicted membrane protein [Function unknown]; Region: COG2259 909946009751 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 909946009752 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 909946009753 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 909946009754 putative dimer interface [polypeptide binding]; other site 909946009755 N-terminal domain interface [polypeptide binding]; other site 909946009756 putative substrate binding pocket (H-site) [chemical binding]; other site 909946009757 Predicted membrane protein [Function unknown]; Region: COG3152 909946009758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946009759 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 909946009760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 909946009761 dimerization interface [polypeptide binding]; other site 909946009762 Pirin-related protein [General function prediction only]; Region: COG1741 909946009763 Pirin; Region: Pirin; pfam02678 909946009764 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 909946009765 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 909946009766 serine transporter; Region: stp; TIGR00814 909946009767 L-serine dehydratase TdcG; Provisional; Region: PRK15040 909946009768 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 909946009769 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 909946009770 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 909946009771 Pyruvate formate lyase 1; Region: PFL1; cd01678 909946009772 coenzyme A binding site [chemical binding]; other site 909946009773 active site 909946009774 catalytic residues [active] 909946009775 glycine loop; other site 909946009776 propionate/acetate kinase; Provisional; Region: PRK12379 909946009777 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 909946009778 threonine/serine transporter TdcC; Provisional; Region: PRK13629 909946009779 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 909946009780 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 909946009781 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 909946009782 tetramer interface [polypeptide binding]; other site 909946009783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946009784 catalytic residue [active] 909946009785 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 909946009786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946009787 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 909946009788 putative substrate binding pocket [chemical binding]; other site 909946009789 putative dimerization interface [polypeptide binding]; other site 909946009790 glycerate kinase I; Provisional; Region: PRK10342 909946009791 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 909946009792 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 909946009793 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 909946009794 galactarate dehydratase; Region: galactar-dH20; TIGR03248 909946009795 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 909946009796 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 909946009797 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909946009798 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 909946009799 substrate binding site [chemical binding]; other site 909946009800 ATP binding site [chemical binding]; other site 909946009801 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909946009802 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 909946009803 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946009804 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 909946009805 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 909946009806 intersubunit interface [polypeptide binding]; other site 909946009807 active site 909946009808 zinc binding site [ion binding]; other site 909946009809 Na+ binding site [ion binding]; other site 909946009810 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 909946009811 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 909946009812 putative substrate binding site [chemical binding]; other site 909946009813 putative ATP binding site [chemical binding]; other site 909946009814 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 909946009815 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 909946009816 active site 909946009817 P-loop; other site 909946009818 phosphorylation site [posttranslational modification] 909946009819 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 909946009820 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909946009821 active site 909946009822 phosphorylation site [posttranslational modification] 909946009823 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 909946009824 dimerization domain swap beta strand [polypeptide binding]; other site 909946009825 regulatory protein interface [polypeptide binding]; other site 909946009826 active site 909946009827 regulatory phosphorylation site [posttranslational modification]; other site 909946009828 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 909946009829 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909946009830 active site 909946009831 phosphorylation site [posttranslational modification] 909946009832 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 909946009833 active site 909946009834 P-loop; other site 909946009835 phosphorylation site [posttranslational modification] 909946009836 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 909946009837 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 909946009838 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 909946009839 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 909946009840 putative NAD(P) binding site [chemical binding]; other site 909946009841 catalytic Zn binding site [ion binding]; other site 909946009842 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909946009843 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 909946009844 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946009845 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 909946009846 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 909946009847 putative SAM binding site [chemical binding]; other site 909946009848 putative homodimer interface [polypeptide binding]; other site 909946009849 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 909946009850 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 909946009851 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 909946009852 putative ligand binding site [chemical binding]; other site 909946009853 TIGR00252 family protein; Region: TIGR00252 909946009854 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 909946009855 dimer interface [polypeptide binding]; other site 909946009856 active site 909946009857 outer membrane lipoprotein; Provisional; Region: PRK11023 909946009858 BON domain; Region: BON; pfam04972 909946009859 BON domain; Region: BON; pfam04972 909946009860 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 909946009861 NADH(P)-binding; Region: NAD_binding_10; pfam13460 909946009862 NAD binding site [chemical binding]; other site 909946009863 active site 909946009864 intracellular protease, PfpI family; Region: PfpI; TIGR01382 909946009865 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 909946009866 proposed catalytic triad [active] 909946009867 conserved cys residue [active] 909946009868 hypothetical protein; Provisional; Region: PRK03467 909946009869 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 909946009870 GIY-YIG motif/motif A; other site 909946009871 putative active site [active] 909946009872 putative metal binding site [ion binding]; other site 909946009873 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 909946009874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946009875 Coenzyme A binding pocket [chemical binding]; other site 909946009876 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 909946009877 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 909946009878 Peptidase family U32; Region: Peptidase_U32; pfam01136 909946009879 putative protease; Provisional; Region: PRK15447 909946009880 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 909946009881 hypothetical protein; Provisional; Region: PRK10508 909946009882 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 909946009883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 909946009884 tryptophan permease; Provisional; Region: PRK10483 909946009885 aromatic amino acid transport protein; Region: araaP; TIGR00837 909946009886 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 909946009887 DEAD-like helicases superfamily; Region: DEXDc; smart00487 909946009888 ATP binding site [chemical binding]; other site 909946009889 Mg++ binding site [ion binding]; other site 909946009890 motif III; other site 909946009891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946009892 nucleotide binding region [chemical binding]; other site 909946009893 ATP-binding site [chemical binding]; other site 909946009894 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 909946009895 putative RNA binding site [nucleotide binding]; other site 909946009896 lipoprotein NlpI; Provisional; Region: PRK11189 909946009897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 909946009898 binding surface 909946009899 TPR motif; other site 909946009900 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 909946009901 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 909946009902 RNase E interface [polypeptide binding]; other site 909946009903 trimer interface [polypeptide binding]; other site 909946009904 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 909946009905 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 909946009906 RNase E interface [polypeptide binding]; other site 909946009907 trimer interface [polypeptide binding]; other site 909946009908 active site 909946009909 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 909946009910 putative nucleic acid binding region [nucleotide binding]; other site 909946009911 G-X-X-G motif; other site 909946009912 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 909946009913 RNA binding site [nucleotide binding]; other site 909946009914 domain interface; other site 909946009915 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 909946009916 16S/18S rRNA binding site [nucleotide binding]; other site 909946009917 S13e-L30e interaction site [polypeptide binding]; other site 909946009918 25S rRNA binding site [nucleotide binding]; other site 909946009919 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 909946009920 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 909946009921 RNA binding site [nucleotide binding]; other site 909946009922 active site 909946009923 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 909946009924 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 909946009925 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 909946009926 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 909946009927 translation initiation factor IF-2; Region: IF-2; TIGR00487 909946009928 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 909946009929 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 909946009930 G1 box; other site 909946009931 putative GEF interaction site [polypeptide binding]; other site 909946009932 GTP/Mg2+ binding site [chemical binding]; other site 909946009933 Switch I region; other site 909946009934 G2 box; other site 909946009935 G3 box; other site 909946009936 Switch II region; other site 909946009937 G4 box; other site 909946009938 G5 box; other site 909946009939 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 909946009940 Translation-initiation factor 2; Region: IF-2; pfam11987 909946009941 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 909946009942 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 909946009943 NusA N-terminal domain; Region: NusA_N; pfam08529 909946009944 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 909946009945 RNA binding site [nucleotide binding]; other site 909946009946 homodimer interface [polypeptide binding]; other site 909946009947 NusA-like KH domain; Region: KH_5; pfam13184 909946009948 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 909946009949 G-X-X-G motif; other site 909946009950 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 909946009951 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 909946009952 ribosome maturation protein RimP; Reviewed; Region: PRK00092 909946009953 Sm and related proteins; Region: Sm_like; cl00259 909946009954 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 909946009955 putative oligomer interface [polypeptide binding]; other site 909946009956 putative RNA binding site [nucleotide binding]; other site 909946009957 argininosuccinate synthase; Validated; Region: PRK05370 909946009958 argininosuccinate synthase; Provisional; Region: PRK13820 909946009959 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 909946009960 Preprotein translocase SecG subunit; Region: SecG; pfam03840 909946009961 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 909946009962 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 909946009963 active site 909946009964 substrate binding site [chemical binding]; other site 909946009965 metal binding site [ion binding]; metal-binding site 909946009966 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 909946009967 dihydropteroate synthase; Region: DHPS; TIGR01496 909946009968 substrate binding pocket [chemical binding]; other site 909946009969 dimer interface [polypeptide binding]; other site 909946009970 inhibitor binding site; inhibition site 909946009971 Transposase IS200 like; Region: Y1_Tnp; pfam01797 909946009972 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 909946009973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946009974 Walker A motif; other site 909946009975 ATP binding site [chemical binding]; other site 909946009976 Walker B motif; other site 909946009977 arginine finger; other site 909946009978 Peptidase family M41; Region: Peptidase_M41; pfam01434 909946009979 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 909946009980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946009981 S-adenosylmethionine binding site [chemical binding]; other site 909946009982 RNA-binding protein YhbY; Provisional; Region: PRK10343 909946009983 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 909946009984 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 909946009985 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 909946009986 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 909946009987 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 909946009988 GTPase CgtA; Reviewed; Region: obgE; PRK12298 909946009989 GTP1/OBG; Region: GTP1_OBG; pfam01018 909946009990 Obg GTPase; Region: Obg; cd01898 909946009991 G1 box; other site 909946009992 GTP/Mg2+ binding site [chemical binding]; other site 909946009993 Switch I region; other site 909946009994 G2 box; other site 909946009995 G3 box; other site 909946009996 Switch II region; other site 909946009997 G4 box; other site 909946009998 G5 box; other site 909946009999 EamA-like transporter family; Region: EamA; pfam00892 909946010000 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 909946010001 EamA-like transporter family; Region: EamA; pfam00892 909946010002 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 909946010003 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 909946010004 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 909946010005 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 909946010006 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 909946010007 substrate binding pocket [chemical binding]; other site 909946010008 chain length determination region; other site 909946010009 substrate-Mg2+ binding site; other site 909946010010 catalytic residues [active] 909946010011 aspartate-rich region 1; other site 909946010012 active site lid residues [active] 909946010013 aspartate-rich region 2; other site 909946010014 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 909946010015 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 909946010016 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 909946010017 hinge; other site 909946010018 active site 909946010019 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 909946010020 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 909946010021 anti sigma factor interaction site; other site 909946010022 regulatory phosphorylation site [posttranslational modification]; other site 909946010023 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 909946010024 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 909946010025 mce related protein; Region: MCE; pfam02470 909946010026 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 909946010027 conserved hypothetical integral membrane protein; Region: TIGR00056 909946010028 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 909946010029 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 909946010030 Walker A/P-loop; other site 909946010031 ATP binding site [chemical binding]; other site 909946010032 Q-loop/lid; other site 909946010033 ABC transporter signature motif; other site 909946010034 Walker B; other site 909946010035 D-loop; other site 909946010036 H-loop/switch region; other site 909946010037 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 909946010038 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 909946010039 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 909946010040 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 909946010041 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 909946010042 putative active site [active] 909946010043 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 909946010044 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 909946010045 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 909946010046 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 909946010047 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 909946010048 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 909946010049 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 909946010050 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 909946010051 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 909946010052 Walker A/P-loop; other site 909946010053 ATP binding site [chemical binding]; other site 909946010054 Q-loop/lid; other site 909946010055 ABC transporter signature motif; other site 909946010056 Walker B; other site 909946010057 D-loop; other site 909946010058 H-loop/switch region; other site 909946010059 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 909946010060 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 909946010061 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 909946010062 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 909946010063 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 909946010064 30S subunit binding site; other site 909946010065 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909946010066 active site 909946010067 phosphorylation site [posttranslational modification] 909946010068 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 909946010069 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 909946010070 dimerization domain swap beta strand [polypeptide binding]; other site 909946010071 regulatory protein interface [polypeptide binding]; other site 909946010072 active site 909946010073 regulatory phosphorylation site [posttranslational modification]; other site 909946010074 hypothetical protein; Provisional; Region: PRK10345 909946010075 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 909946010076 Transglycosylase; Region: Transgly; cl17702 909946010077 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 909946010078 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 909946010079 conserved cys residue [active] 909946010080 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 909946010081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 909946010082 putative active site [active] 909946010083 heme pocket [chemical binding]; other site 909946010084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946010085 dimer interface [polypeptide binding]; other site 909946010086 phosphorylation site [posttranslational modification] 909946010087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946010088 ATP binding site [chemical binding]; other site 909946010089 Mg2+ binding site [ion binding]; other site 909946010090 G-X-G motif; other site 909946010091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946010092 active site 909946010093 phosphorylation site [posttranslational modification] 909946010094 intermolecular recognition site; other site 909946010095 dimerization interface [polypeptide binding]; other site 909946010096 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 909946010097 putative binding surface; other site 909946010098 active site 909946010099 radical SAM protein, TIGR01212 family; Region: TIGR01212 909946010100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946010101 FeS/SAM binding site; other site 909946010102 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 909946010103 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 909946010104 active site 909946010105 dimer interface [polypeptide binding]; other site 909946010106 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 909946010107 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 909946010108 active site 909946010109 FMN binding site [chemical binding]; other site 909946010110 substrate binding site [chemical binding]; other site 909946010111 3Fe-4S cluster binding site [ion binding]; other site 909946010112 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 909946010113 domain interface; other site 909946010114 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 909946010115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909946010116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909946010117 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 909946010118 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 909946010119 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 909946010120 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 909946010121 Na binding site [ion binding]; other site 909946010122 putative substrate binding site [chemical binding]; other site 909946010123 cytosine deaminase; Provisional; Region: PRK09230 909946010124 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 909946010125 active site 909946010126 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 909946010127 N-acetylmannosamine kinase; Provisional; Region: PRK05082 909946010128 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 909946010129 nucleotide binding site [chemical binding]; other site 909946010130 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 909946010131 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 909946010132 putative active site cavity [active] 909946010133 putative sialic acid transporter; Provisional; Region: PRK03893 909946010134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946010135 putative substrate translocation pore; other site 909946010136 N-acetylneuraminate lyase; Provisional; Region: PRK04147 909946010137 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 909946010138 inhibitor site; inhibition site 909946010139 active site 909946010140 dimer interface [polypeptide binding]; other site 909946010141 catalytic residue [active] 909946010142 transcriptional regulator NanR; Provisional; Region: PRK03837 909946010143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946010144 DNA-binding site [nucleotide binding]; DNA binding site 909946010145 FCD domain; Region: FCD; pfam07729 909946010146 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 909946010147 stringent starvation protein A; Provisional; Region: sspA; PRK09481 909946010148 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 909946010149 C-terminal domain interface [polypeptide binding]; other site 909946010150 putative GSH binding site (G-site) [chemical binding]; other site 909946010151 dimer interface [polypeptide binding]; other site 909946010152 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 909946010153 dimer interface [polypeptide binding]; other site 909946010154 N-terminal domain interface [polypeptide binding]; other site 909946010155 Family of unknown function (DUF695); Region: DUF695; pfam05117 909946010156 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 909946010157 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 909946010158 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 909946010159 23S rRNA interface [nucleotide binding]; other site 909946010160 L3 interface [polypeptide binding]; other site 909946010161 Predicted ATPase [General function prediction only]; Region: COG1485 909946010162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 909946010163 hypothetical protein; Provisional; Region: PRK11677 909946010164 serine endoprotease; Provisional; Region: PRK10139 909946010165 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 909946010166 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 909946010167 protein binding site [polypeptide binding]; other site 909946010168 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 909946010169 serine endoprotease; Provisional; Region: PRK10898 909946010170 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 909946010171 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 909946010172 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 909946010173 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 909946010174 oxaloacetate decarboxylase; Provisional; Region: PRK14040 909946010175 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 909946010176 active site 909946010177 catalytic residues [active] 909946010178 metal binding site [ion binding]; metal-binding site 909946010179 homodimer binding site [polypeptide binding]; other site 909946010180 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 909946010181 carboxyltransferase (CT) interaction site; other site 909946010182 biotinylation site [posttranslational modification]; other site 909946010183 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 909946010184 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 909946010185 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 909946010186 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 909946010187 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 909946010188 transmembrane helices; other site 909946010189 Transcriptional regulators [Transcription]; Region: GntR; COG1802 909946010190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946010191 DNA-binding site [nucleotide binding]; DNA binding site 909946010192 FCD domain; Region: FCD; pfam07729 909946010193 Transcriptional regulators [Transcription]; Region: GntR; COG1802 909946010194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946010195 DNA-binding site [nucleotide binding]; DNA binding site 909946010196 malate dehydrogenase; Provisional; Region: PRK05086 909946010197 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 909946010198 NAD binding site [chemical binding]; other site 909946010199 dimerization interface [polypeptide binding]; other site 909946010200 Substrate binding site [chemical binding]; other site 909946010201 arginine repressor; Provisional; Region: PRK05066 909946010202 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 909946010203 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 909946010204 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 909946010205 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 909946010206 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 909946010207 RNAase interaction site [polypeptide binding]; other site 909946010208 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 909946010209 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 909946010210 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 909946010211 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 909946010212 HlyD family secretion protein; Region: HlyD_3; pfam13437 909946010213 efflux system membrane protein; Provisional; Region: PRK11594 909946010214 transcriptional regulator; Provisional; Region: PRK10632 909946010215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946010216 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 909946010217 putative effector binding pocket; other site 909946010218 dimerization interface [polypeptide binding]; other site 909946010219 protease TldD; Provisional; Region: tldD; PRK10735 909946010220 hypothetical protein; Provisional; Region: PRK10899 909946010221 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 909946010222 ribonuclease G; Provisional; Region: PRK11712 909946010223 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 909946010224 homodimer interface [polypeptide binding]; other site 909946010225 oligonucleotide binding site [chemical binding]; other site 909946010226 Maf-like protein; Region: Maf; pfam02545 909946010227 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 909946010228 active site 909946010229 dimer interface [polypeptide binding]; other site 909946010230 rod shape-determining protein MreD; Provisional; Region: PRK11060 909946010231 rod shape-determining protein MreC; Region: mreC; TIGR00219 909946010232 rod shape-determining protein MreC; Region: MreC; pfam04085 909946010233 rod shape-determining protein MreB; Provisional; Region: PRK13927 909946010234 MreB and similar proteins; Region: MreB_like; cd10225 909946010235 nucleotide binding site [chemical binding]; other site 909946010236 Mg binding site [ion binding]; other site 909946010237 putative protofilament interaction site [polypeptide binding]; other site 909946010238 RodZ interaction site [polypeptide binding]; other site 909946010239 regulatory protein CsrD; Provisional; Region: PRK11059 909946010240 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 909946010241 metal binding site [ion binding]; metal-binding site 909946010242 active site 909946010243 I-site; other site 909946010244 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946010245 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 909946010246 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 909946010247 NADP binding site [chemical binding]; other site 909946010248 dimer interface [polypeptide binding]; other site 909946010249 TMAO/DMSO reductase; Reviewed; Region: PRK05363 909946010250 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 909946010251 Moco binding site; other site 909946010252 metal coordination site [ion binding]; other site 909946010253 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 909946010254 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 909946010255 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 909946010256 carboxyltransferase (CT) interaction site; other site 909946010257 biotinylation site [posttranslational modification]; other site 909946010258 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 909946010259 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 909946010260 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 909946010261 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 909946010262 hypothetical protein; Provisional; Region: PRK10633 909946010263 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 909946010264 Na binding site [ion binding]; other site 909946010265 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 909946010266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 909946010267 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 909946010268 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 909946010269 FMN binding site [chemical binding]; other site 909946010270 active site 909946010271 catalytic residues [active] 909946010272 substrate binding site [chemical binding]; other site 909946010273 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 909946010274 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 909946010275 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 909946010276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946010277 DNA methylase; Region: N6_N4_Mtase; pfam01555 909946010278 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 909946010279 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 909946010280 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 909946010281 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 909946010282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 909946010283 metal binding site [ion binding]; metal-binding site 909946010284 active site 909946010285 I-site; other site 909946010286 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946010287 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 909946010288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946010289 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 909946010290 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 909946010291 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 909946010292 HlyD family secretion protein; Region: HlyD_3; pfam13437 909946010293 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 909946010294 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 909946010295 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 909946010296 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 909946010297 trimer interface [polypeptide binding]; other site 909946010298 putative metal binding site [ion binding]; other site 909946010299 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 909946010300 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 909946010301 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 909946010302 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 909946010303 shikimate binding site; other site 909946010304 NAD(P) binding site [chemical binding]; other site 909946010305 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 909946010306 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 909946010307 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 909946010308 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 909946010309 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 909946010310 hypothetical protein; Validated; Region: PRK03430 909946010311 hypothetical protein; Provisional; Region: PRK10736 909946010312 DNA protecting protein DprA; Region: dprA; TIGR00732 909946010313 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 909946010314 active site 909946010315 catalytic residues [active] 909946010316 metal binding site [ion binding]; metal-binding site 909946010317 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 909946010318 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 909946010319 putative active site [active] 909946010320 substrate binding site [chemical binding]; other site 909946010321 putative cosubstrate binding site; other site 909946010322 catalytic site [active] 909946010323 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 909946010324 substrate binding site [chemical binding]; other site 909946010325 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 909946010326 putative RNA binding site [nucleotide binding]; other site 909946010327 16S rRNA methyltransferase B; Provisional; Region: PRK10901 909946010328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946010329 S-adenosylmethionine binding site [chemical binding]; other site 909946010330 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 909946010331 TrkA-N domain; Region: TrkA_N; pfam02254 909946010332 TrkA-C domain; Region: TrkA_C; pfam02080 909946010333 TrkA-N domain; Region: TrkA_N; pfam02254 909946010334 TrkA-C domain; Region: TrkA_C; pfam02080 909946010335 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 909946010336 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 909946010337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 909946010338 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 909946010339 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 909946010340 DNA binding residues [nucleotide binding] 909946010341 dimer interface [polypeptide binding]; other site 909946010342 metal binding site [ion binding]; metal-binding site 909946010343 hypothetical protein; Provisional; Region: PRK10203 909946010344 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 909946010345 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 909946010346 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 909946010347 alphaNTD homodimer interface [polypeptide binding]; other site 909946010348 alphaNTD - beta interaction site [polypeptide binding]; other site 909946010349 alphaNTD - beta' interaction site [polypeptide binding]; other site 909946010350 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 909946010351 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 909946010352 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 909946010353 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909946010354 RNA binding surface [nucleotide binding]; other site 909946010355 30S ribosomal protein S11; Validated; Region: PRK05309 909946010356 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 909946010357 30S ribosomal protein S13; Region: bact_S13; TIGR03631 909946010358 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 909946010359 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 909946010360 SecY translocase; Region: SecY; pfam00344 909946010361 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 909946010362 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 909946010363 23S rRNA binding site [nucleotide binding]; other site 909946010364 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 909946010365 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 909946010366 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 909946010367 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 909946010368 23S rRNA interface [nucleotide binding]; other site 909946010369 5S rRNA interface [nucleotide binding]; other site 909946010370 L27 interface [polypeptide binding]; other site 909946010371 L5 interface [polypeptide binding]; other site 909946010372 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 909946010373 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 909946010374 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 909946010375 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 909946010376 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 909946010377 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 909946010378 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 909946010379 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 909946010380 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 909946010381 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 909946010382 RNA binding site [nucleotide binding]; other site 909946010383 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 909946010384 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 909946010385 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 909946010386 23S rRNA interface [nucleotide binding]; other site 909946010387 putative translocon interaction site; other site 909946010388 signal recognition particle (SRP54) interaction site; other site 909946010389 L23 interface [polypeptide binding]; other site 909946010390 trigger factor interaction site; other site 909946010391 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 909946010392 23S rRNA interface [nucleotide binding]; other site 909946010393 5S rRNA interface [nucleotide binding]; other site 909946010394 putative antibiotic binding site [chemical binding]; other site 909946010395 L25 interface [polypeptide binding]; other site 909946010396 L27 interface [polypeptide binding]; other site 909946010397 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 909946010398 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 909946010399 G-X-X-G motif; other site 909946010400 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 909946010401 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 909946010402 protein-rRNA interface [nucleotide binding]; other site 909946010403 putative translocon binding site; other site 909946010404 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 909946010405 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 909946010406 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 909946010407 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 909946010408 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 909946010409 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 909946010410 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 909946010411 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 909946010412 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 909946010413 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 909946010414 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 909946010415 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 909946010416 heme binding site [chemical binding]; other site 909946010417 ferroxidase pore; other site 909946010418 ferroxidase diiron center [ion binding]; other site 909946010419 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 909946010420 elongation factor Tu; Reviewed; Region: PRK00049 909946010421 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 909946010422 G1 box; other site 909946010423 GEF interaction site [polypeptide binding]; other site 909946010424 GTP/Mg2+ binding site [chemical binding]; other site 909946010425 Switch I region; other site 909946010426 G2 box; other site 909946010427 G3 box; other site 909946010428 Switch II region; other site 909946010429 G4 box; other site 909946010430 G5 box; other site 909946010431 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 909946010432 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 909946010433 Antibiotic Binding Site [chemical binding]; other site 909946010434 elongation factor G; Reviewed; Region: PRK00007 909946010435 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 909946010436 G1 box; other site 909946010437 putative GEF interaction site [polypeptide binding]; other site 909946010438 GTP/Mg2+ binding site [chemical binding]; other site 909946010439 Switch I region; other site 909946010440 G2 box; other site 909946010441 G3 box; other site 909946010442 Switch II region; other site 909946010443 G4 box; other site 909946010444 G5 box; other site 909946010445 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 909946010446 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 909946010447 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 909946010448 30S ribosomal protein S7; Validated; Region: PRK05302 909946010449 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 909946010450 S17 interaction site [polypeptide binding]; other site 909946010451 S8 interaction site; other site 909946010452 16S rRNA interaction site [nucleotide binding]; other site 909946010453 streptomycin interaction site [chemical binding]; other site 909946010454 23S rRNA interaction site [nucleotide binding]; other site 909946010455 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 909946010456 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 909946010457 sulfur relay protein TusC; Validated; Region: PRK00211 909946010458 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 909946010459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 909946010460 YheO-like PAS domain; Region: PAS_6; pfam08348 909946010461 HTH domain; Region: HTH_22; pfam13309 909946010462 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 909946010463 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 909946010464 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 909946010465 phi X174 lysis protein; Provisional; Region: PRK02793 909946010466 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 909946010467 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 909946010468 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 909946010469 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 909946010470 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 909946010471 TrkA-N domain; Region: TrkA_N; pfam02254 909946010472 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 909946010473 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 909946010474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946010475 Walker A/P-loop; other site 909946010476 ATP binding site [chemical binding]; other site 909946010477 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909946010478 ABC transporter signature motif; other site 909946010479 Walker B; other site 909946010480 D-loop; other site 909946010481 ABC transporter; Region: ABC_tran_2; pfam12848 909946010482 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909946010483 putative monooxygenase; Provisional; Region: PRK11118 909946010484 putative hydrolase; Provisional; Region: PRK10985 909946010485 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 909946010486 hypothetical protein; Provisional; Region: PRK04966 909946010487 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 909946010488 active site 909946010489 hypothetical protein; Provisional; Region: PRK10738 909946010490 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 909946010491 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 909946010492 ligand binding site [chemical binding]; other site 909946010493 flexible hinge region; other site 909946010494 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 909946010495 putative switch regulator; other site 909946010496 non-specific DNA interactions [nucleotide binding]; other site 909946010497 DNA binding site [nucleotide binding] 909946010498 sequence specific DNA binding site [nucleotide binding]; other site 909946010499 putative cAMP binding site [chemical binding]; other site 909946010500 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 909946010501 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 909946010502 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 909946010503 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 909946010504 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 909946010505 inhibitor-cofactor binding pocket; inhibition site 909946010506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946010507 catalytic residue [active] 909946010508 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 909946010509 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 909946010510 glutamine binding [chemical binding]; other site 909946010511 catalytic triad [active] 909946010512 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 909946010513 cell filamentation protein Fic; Provisional; Region: PRK10347 909946010514 hypothetical protein; Provisional; Region: PRK10204 909946010515 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 909946010516 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 909946010517 substrate binding site [chemical binding]; other site 909946010518 putative transporter; Provisional; Region: PRK03699 909946010519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946010520 putative substrate translocation pore; other site 909946010521 nitrite reductase subunit NirD; Provisional; Region: PRK14989 909946010522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909946010523 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 909946010524 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 909946010525 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 909946010526 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 909946010527 nitrite transporter NirC; Provisional; Region: PRK11562 909946010528 siroheme synthase; Provisional; Region: cysG; PRK10637 909946010529 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 909946010530 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 909946010531 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 909946010532 active site 909946010533 SAM binding site [chemical binding]; other site 909946010534 homodimer interface [polypeptide binding]; other site 909946010535 Autotransporter beta-domain; Region: Autotransporter; pfam03797 909946010536 Transposase IS200 like; Region: Y1_Tnp; pfam01797 909946010537 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 909946010538 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 909946010539 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 909946010540 active site 909946010541 HIGH motif; other site 909946010542 dimer interface [polypeptide binding]; other site 909946010543 KMSKS motif; other site 909946010544 phosphoglycolate phosphatase; Provisional; Region: PRK13222 909946010545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946010546 motif II; other site 909946010547 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 909946010548 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 909946010549 substrate binding site [chemical binding]; other site 909946010550 hexamer interface [polypeptide binding]; other site 909946010551 metal binding site [ion binding]; metal-binding site 909946010552 DNA adenine methylase; Provisional; Region: PRK10904 909946010553 cell division protein DamX; Validated; Region: PRK10905 909946010554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 909946010555 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 909946010556 active site 909946010557 dimer interface [polypeptide binding]; other site 909946010558 metal binding site [ion binding]; metal-binding site 909946010559 shikimate kinase; Reviewed; Region: aroK; PRK00131 909946010560 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 909946010561 ADP binding site [chemical binding]; other site 909946010562 magnesium binding site [ion binding]; other site 909946010563 putative shikimate binding site; other site 909946010564 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 909946010565 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 909946010566 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 909946010567 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 909946010568 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 909946010569 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 909946010570 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 909946010571 Transglycosylase; Region: Transgly; pfam00912 909946010572 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 909946010573 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 909946010574 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 909946010575 ADP-ribose binding site [chemical binding]; other site 909946010576 dimer interface [polypeptide binding]; other site 909946010577 active site 909946010578 nudix motif; other site 909946010579 metal binding site [ion binding]; metal-binding site 909946010580 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 909946010581 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 909946010582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946010583 motif II; other site 909946010584 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909946010585 RNA binding surface [nucleotide binding]; other site 909946010586 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 909946010587 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 909946010588 dimerization interface [polypeptide binding]; other site 909946010589 domain crossover interface; other site 909946010590 redox-dependent activation switch; other site 909946010591 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 909946010592 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 909946010593 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 909946010594 active site 909946010595 substrate-binding site [chemical binding]; other site 909946010596 metal-binding site [ion binding] 909946010597 ATP binding site [chemical binding]; other site 909946010598 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 909946010599 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946010600 dimerization interface [polypeptide binding]; other site 909946010601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946010602 dimer interface [polypeptide binding]; other site 909946010603 phosphorylation site [posttranslational modification] 909946010604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946010605 ATP binding site [chemical binding]; other site 909946010606 G-X-G motif; other site 909946010607 osmolarity response regulator; Provisional; Region: ompR; PRK09468 909946010608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946010609 active site 909946010610 phosphorylation site [posttranslational modification] 909946010611 intermolecular recognition site; other site 909946010612 dimerization interface [polypeptide binding]; other site 909946010613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946010614 DNA binding site [nucleotide binding] 909946010615 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 909946010616 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 909946010617 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 909946010618 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 909946010619 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 909946010620 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 909946010621 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 909946010622 RNA binding site [nucleotide binding]; other site 909946010623 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 909946010624 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 909946010625 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 909946010626 G1 box; other site 909946010627 GTP/Mg2+ binding site [chemical binding]; other site 909946010628 Switch I region; other site 909946010629 G2 box; other site 909946010630 G3 box; other site 909946010631 Switch II region; other site 909946010632 G4 box; other site 909946010633 G5 box; other site 909946010634 Nucleoside recognition; Region: Gate; pfam07670 909946010635 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 909946010636 Nucleoside recognition; Region: Gate; pfam07670 909946010637 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 909946010638 hypothetical protein; Provisional; Region: PRK09956 909946010639 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 909946010640 carboxylesterase BioH; Provisional; Region: PRK10349 909946010641 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 909946010642 DNA utilization protein GntX; Provisional; Region: PRK11595 909946010643 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909946010644 active site 909946010645 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 909946010646 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 909946010647 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 909946010648 high-affinity gluconate transporter; Provisional; Region: PRK14984 909946010649 gluconate transporter; Region: gntP; TIGR00791 909946010650 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 909946010651 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 909946010652 maltodextrin phosphorylase; Provisional; Region: PRK14985 909946010653 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 909946010654 homodimer interface [polypeptide binding]; other site 909946010655 active site pocket [active] 909946010656 transcriptional regulator MalT; Provisional; Region: PRK04841 909946010657 AAA ATPase domain; Region: AAA_16; pfam13191 909946010658 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946010659 DNA binding residues [nucleotide binding] 909946010660 dimerization interface [polypeptide binding]; other site 909946010661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 909946010662 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 909946010663 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 909946010664 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 909946010665 putative active site [active] 909946010666 adenylation catalytic residue [active] 909946010667 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 909946010668 hypothetical protein; Reviewed; Region: PRK09588 909946010669 TROVE domain; Region: TROVE; pfam05731 909946010670 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 909946010671 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 909946010672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946010673 Walker A motif; other site 909946010674 ATP binding site [chemical binding]; other site 909946010675 Walker B motif; other site 909946010676 arginine finger; other site 909946010677 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 909946010678 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 909946010679 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946010680 intramembrane serine protease GlpG; Provisional; Region: PRK10907 909946010681 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 909946010682 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 909946010683 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 909946010684 active site residue [active] 909946010685 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 909946010686 hypothetical protein; Provisional; Region: PRK09781 909946010687 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 909946010688 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 909946010689 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 909946010690 dimer interface [polypeptide binding]; other site 909946010691 active site 909946010692 metal binding site [ion binding]; metal-binding site 909946010693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946010694 D-galactonate transporter; Region: 2A0114; TIGR00893 909946010695 putative substrate translocation pore; other site 909946010696 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 909946010697 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 909946010698 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 909946010699 inhibitor site; inhibition site 909946010700 active site 909946010701 dimer interface [polypeptide binding]; other site 909946010702 catalytic residue [active] 909946010703 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 909946010704 Transcriptional regulator [Transcription]; Region: IclR; COG1414 909946010705 Bacterial transcriptional regulator; Region: IclR; pfam01614 909946010706 glycogen phosphorylase; Provisional; Region: PRK14986 909946010707 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 909946010708 homodimer interface [polypeptide binding]; other site 909946010709 active site pocket [active] 909946010710 glycogen synthase; Provisional; Region: glgA; PRK00654 909946010711 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 909946010712 ADP-binding pocket [chemical binding]; other site 909946010713 homodimer interface [polypeptide binding]; other site 909946010714 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 909946010715 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 909946010716 ligand binding site; other site 909946010717 oligomer interface; other site 909946010718 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 909946010719 dimer interface [polypeptide binding]; other site 909946010720 N-terminal domain interface [polypeptide binding]; other site 909946010721 sulfate 1 binding site; other site 909946010722 glycogen debranching enzyme; Provisional; Region: PRK03705 909946010723 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 909946010724 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 909946010725 active site 909946010726 catalytic site [active] 909946010727 glycogen branching enzyme; Provisional; Region: PRK05402 909946010728 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 909946010729 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 909946010730 active site 909946010731 catalytic site [active] 909946010732 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 909946010733 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 909946010734 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 909946010735 low affinity gluconate transporter; Provisional; Region: PRK10472 909946010736 gluconate transporter; Region: gntP; TIGR00791 909946010737 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 909946010738 ATP-binding site [chemical binding]; other site 909946010739 Gluconate-6-phosphate binding site [chemical binding]; other site 909946010740 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 909946010741 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946010742 DNA binding site [nucleotide binding] 909946010743 domain linker motif; other site 909946010744 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 909946010745 putative ligand binding site [chemical binding]; other site 909946010746 putative dimerization interface [polypeptide binding]; other site 909946010747 Pirin-related protein [General function prediction only]; Region: COG1741 909946010748 Pirin; Region: Pirin; pfam02678 909946010749 putative oxidoreductase; Provisional; Region: PRK10206 909946010750 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909946010751 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909946010752 putative acetyltransferase YhhY; Provisional; Region: PRK10140 909946010753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946010754 Coenzyme A binding pocket [chemical binding]; other site 909946010755 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909946010756 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 909946010757 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909946010758 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 909946010759 substrate binding site [chemical binding]; other site 909946010760 dimer interface [polypeptide binding]; other site 909946010761 ATP binding site [chemical binding]; other site 909946010762 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 909946010763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 909946010764 Protein of unknown function, DUF606; Region: DUF606; pfam04657 909946010765 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 909946010766 active site 909946010767 substrate binding pocket [chemical binding]; other site 909946010768 homodimer interaction site [polypeptide binding]; other site 909946010769 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 909946010770 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 909946010771 hypothetical protein; Provisional; Region: PRK10350 909946010772 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 909946010773 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 909946010774 putative active site [active] 909946010775 catalytic site [active] 909946010776 putative metal binding site [ion binding]; other site 909946010777 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 909946010778 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 909946010779 Walker A/P-loop; other site 909946010780 ATP binding site [chemical binding]; other site 909946010781 Q-loop/lid; other site 909946010782 ABC transporter signature motif; other site 909946010783 Walker B; other site 909946010784 D-loop; other site 909946010785 H-loop/switch region; other site 909946010786 TOBE domain; Region: TOBE_2; pfam08402 909946010787 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 909946010788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946010789 dimer interface [polypeptide binding]; other site 909946010790 conserved gate region; other site 909946010791 ABC-ATPase subunit interface; other site 909946010792 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 909946010793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946010794 dimer interface [polypeptide binding]; other site 909946010795 conserved gate region; other site 909946010796 putative PBP binding loops; other site 909946010797 ABC-ATPase subunit interface; other site 909946010798 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 909946010799 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 909946010800 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 909946010801 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 909946010802 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 909946010803 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 909946010804 Walker A/P-loop; other site 909946010805 ATP binding site [chemical binding]; other site 909946010806 Q-loop/lid; other site 909946010807 ABC transporter signature motif; other site 909946010808 Walker B; other site 909946010809 D-loop; other site 909946010810 H-loop/switch region; other site 909946010811 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 909946010812 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 909946010813 Walker A/P-loop; other site 909946010814 ATP binding site [chemical binding]; other site 909946010815 Q-loop/lid; other site 909946010816 ABC transporter signature motif; other site 909946010817 Walker B; other site 909946010818 D-loop; other site 909946010819 H-loop/switch region; other site 909946010820 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 909946010821 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 909946010822 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 909946010823 TM-ABC transporter signature motif; other site 909946010824 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 909946010825 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 909946010826 TM-ABC transporter signature motif; other site 909946010827 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 909946010828 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 909946010829 dimerization interface [polypeptide binding]; other site 909946010830 ligand binding site [chemical binding]; other site 909946010831 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 909946010832 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 909946010833 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 909946010834 dimerization interface [polypeptide binding]; other site 909946010835 ligand binding site [chemical binding]; other site 909946010836 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 909946010837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 909946010838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 909946010839 DNA binding residues [nucleotide binding] 909946010840 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 909946010841 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 909946010842 cell division protein FtsE; Provisional; Region: PRK10908 909946010843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946010844 Walker A/P-loop; other site 909946010845 ATP binding site [chemical binding]; other site 909946010846 Q-loop/lid; other site 909946010847 ABC transporter signature motif; other site 909946010848 Walker B; other site 909946010849 D-loop; other site 909946010850 H-loop/switch region; other site 909946010851 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 909946010852 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 909946010853 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 909946010854 P loop; other site 909946010855 GTP binding site [chemical binding]; other site 909946010856 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 909946010857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946010858 S-adenosylmethionine binding site [chemical binding]; other site 909946010859 hypothetical protein; Provisional; Region: PRK10910 909946010860 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 909946010861 Predicted membrane protein [Function unknown]; Region: COG3714 909946010862 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 909946010863 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 909946010864 metal-binding site [ion binding] 909946010865 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 909946010866 Soluble P-type ATPase [General function prediction only]; Region: COG4087 909946010867 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 909946010868 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 909946010869 dimer interface [polypeptide binding]; other site 909946010870 ligand binding site [chemical binding]; other site 909946010871 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946010872 dimerization interface [polypeptide binding]; other site 909946010873 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 909946010874 dimer interface [polypeptide binding]; other site 909946010875 putative CheW interface [polypeptide binding]; other site 909946010876 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 909946010877 CPxP motif; other site 909946010878 hypothetical protein; Provisional; Region: PRK11212 909946010879 hypothetical protein; Provisional; Region: PRK11615 909946010880 major facilitator superfamily transporter; Provisional; Region: PRK05122 909946010881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946010882 putative substrate translocation pore; other site 909946010883 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 909946010884 Domain of unknown function DUF20; Region: UPF0118; pfam01594 909946010885 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 909946010886 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 909946010887 nickel responsive regulator; Provisional; Region: PRK02967 909946010888 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 909946010889 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 909946010890 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 909946010891 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 909946010892 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 909946010893 Walker A/P-loop; other site 909946010894 ATP binding site [chemical binding]; other site 909946010895 Q-loop/lid; other site 909946010896 ABC transporter signature motif; other site 909946010897 Walker B; other site 909946010898 D-loop; other site 909946010899 H-loop/switch region; other site 909946010900 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 909946010901 Walker A/P-loop; other site 909946010902 ATP binding site [chemical binding]; other site 909946010903 Q-loop/lid; other site 909946010904 ABC transporter signature motif; other site 909946010905 Walker B; other site 909946010906 D-loop; other site 909946010907 H-loop/switch region; other site 909946010908 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 909946010909 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 909946010910 HlyD family secretion protein; Region: HlyD; pfam00529 909946010911 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 909946010912 HlyD family secretion protein; Region: HlyD_3; pfam13437 909946010913 Predicted flavoproteins [General function prediction only]; Region: COG2081 909946010914 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909946010915 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 909946010916 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 909946010917 universal stress protein UspB; Provisional; Region: PRK04960 909946010918 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 909946010919 Ligand Binding Site [chemical binding]; other site 909946010920 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 909946010921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946010922 putative substrate translocation pore; other site 909946010923 POT family; Region: PTR2; pfam00854 909946010924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946010925 S-adenosylmethionine binding site [chemical binding]; other site 909946010926 oligopeptidase A; Provisional; Region: PRK10911 909946010927 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 909946010928 active site 909946010929 Zn binding site [ion binding]; other site 909946010930 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 909946010931 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 909946010932 active site 909946010933 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 909946010934 glutathione reductase; Validated; Region: PRK06116 909946010935 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909946010936 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909946010937 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 909946010938 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 909946010939 active site 909946010940 homodimer interface [polypeptide binding]; other site 909946010941 homotetramer interface [polypeptide binding]; other site 909946010942 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 909946010943 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 909946010944 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 909946010945 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909946010946 substrate binding site [chemical binding]; other site 909946010947 ATP binding site [chemical binding]; other site 909946010948 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 909946010949 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 909946010950 putative active site [active] 909946010951 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 909946010952 dimer interface [polypeptide binding]; other site 909946010953 active site 909946010954 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 909946010955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946010956 DNA-binding site [nucleotide binding]; DNA binding site 909946010957 UTRA domain; Region: UTRA; pfam07702 909946010958 trehalase; Provisional; Region: treF; PRK13270 909946010959 Trehalase; Region: Trehalase; pfam01204 909946010960 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 909946010961 catalytic residue [active] 909946010962 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 909946010963 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946010964 DNA binding residues [nucleotide binding] 909946010965 dimerization interface [polypeptide binding]; other site 909946010966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946010967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946010968 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 909946010969 putative effector binding pocket; other site 909946010970 putative dimerization interface [polypeptide binding]; other site 909946010971 inner membrane protein YhjD; Region: TIGR00766 909946010972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946010973 metabolite-proton symporter; Region: 2A0106; TIGR00883 909946010974 putative substrate translocation pore; other site 909946010975 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 909946010976 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 909946010977 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946010978 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909946010979 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 909946010980 substrate binding site [chemical binding]; other site 909946010981 ATP binding site [chemical binding]; other site 909946010982 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 909946010983 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 909946010984 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 909946010985 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 909946010986 putative diguanylate cyclase; Provisional; Region: PRK13561 909946010987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 909946010988 metal binding site [ion binding]; metal-binding site 909946010989 active site 909946010990 I-site; other site 909946010991 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946010992 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 909946010993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 909946010994 TPR motif; other site 909946010995 binding surface 909946010996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 909946010997 TPR motif; other site 909946010998 binding surface 909946010999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 909946011000 binding surface 909946011001 TPR motif; other site 909946011002 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 909946011003 endo-1,4-D-glucanase; Provisional; Region: PRK11097 909946011004 cellulose synthase regulator protein; Provisional; Region: PRK11114 909946011005 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 909946011006 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 909946011007 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 909946011008 DXD motif; other site 909946011009 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 909946011010 PilZ domain; Region: PilZ; pfam07238 909946011011 cell division protein; Provisional; Region: PRK10037 909946011012 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 909946011013 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 909946011014 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 909946011015 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 909946011016 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 909946011017 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 909946011018 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 909946011019 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 909946011020 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 909946011021 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 909946011022 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 909946011023 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909946011024 Walker A/P-loop; other site 909946011025 ATP binding site [chemical binding]; other site 909946011026 Q-loop/lid; other site 909946011027 ABC transporter signature motif; other site 909946011028 Walker B; other site 909946011029 D-loop; other site 909946011030 H-loop/switch region; other site 909946011031 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 909946011032 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 909946011033 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909946011034 Walker A/P-loop; other site 909946011035 ATP binding site [chemical binding]; other site 909946011036 Q-loop/lid; other site 909946011037 ABC transporter signature motif; other site 909946011038 Walker B; other site 909946011039 D-loop; other site 909946011040 H-loop/switch region; other site 909946011041 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 909946011042 dipeptide transporter; Provisional; Region: PRK10913 909946011043 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 909946011044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946011045 dimer interface [polypeptide binding]; other site 909946011046 conserved gate region; other site 909946011047 putative PBP binding loops; other site 909946011048 ABC-ATPase subunit interface; other site 909946011049 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 909946011050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946011051 dimer interface [polypeptide binding]; other site 909946011052 conserved gate region; other site 909946011053 putative PBP binding loops; other site 909946011054 ABC-ATPase subunit interface; other site 909946011055 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 909946011056 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 909946011057 peptide binding site [polypeptide binding]; other site 909946011058 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 909946011059 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 909946011060 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909946011061 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946011062 DNA binding site [nucleotide binding] 909946011063 domain linker motif; other site 909946011064 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 909946011065 putative dimerization interface [polypeptide binding]; other site 909946011066 putative ligand binding site [chemical binding]; other site 909946011067 phosphoethanolamine transferase; Provisional; Region: PRK11560 909946011068 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 909946011069 Sulfatase; Region: Sulfatase; pfam00884 909946011070 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 909946011071 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 909946011072 PapC N-terminal domain; Region: PapC_N; pfam13954 909946011073 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 909946011074 PapC C-terminal domain; Region: PapC_C; pfam13953 909946011075 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 909946011076 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946011077 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946011078 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 909946011079 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 909946011080 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 909946011081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946011082 Coenzyme A binding pocket [chemical binding]; other site 909946011083 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 909946011084 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 909946011085 molybdopterin cofactor binding site [chemical binding]; other site 909946011086 substrate binding site [chemical binding]; other site 909946011087 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 909946011088 molybdopterin cofactor binding site; other site 909946011089 putative outer membrane lipoprotein; Provisional; Region: PRK10510 909946011090 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 909946011091 ligand binding site [chemical binding]; other site 909946011092 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 909946011093 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 909946011094 dimerization interface [polypeptide binding]; other site 909946011095 ligand binding site [chemical binding]; other site 909946011096 NADP binding site [chemical binding]; other site 909946011097 catalytic site [active] 909946011098 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 909946011099 Predicted transcriptional regulator [Transcription]; Region: COG2944 909946011100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946011101 salt bridge; other site 909946011102 non-specific DNA binding site [nucleotide binding]; other site 909946011103 sequence-specific DNA binding site [nucleotide binding]; other site 909946011104 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 909946011105 DNA-binding site [nucleotide binding]; DNA binding site 909946011106 RNA-binding motif; other site 909946011107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 909946011108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 909946011109 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 909946011110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946011111 Coenzyme A binding pocket [chemical binding]; other site 909946011112 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 909946011113 DALR anticodon binding domain; Region: DALR_1; pfam05746 909946011114 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 909946011115 dimer interface [polypeptide binding]; other site 909946011116 motif 1; other site 909946011117 active site 909946011118 motif 2; other site 909946011119 motif 3; other site 909946011120 YsaB-like lipoprotein; Region: YsaB; pfam13983 909946011121 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 909946011122 Acyltransferase family; Region: Acyl_transf_3; pfam01757 909946011123 Predicted membrane protein [Function unknown]; Region: COG4682 909946011124 yiaA/B two helix domain; Region: YiaAB; cl01759 909946011125 yiaA/B two helix domain; Region: YiaAB; cl01759 909946011126 xylulokinase; Provisional; Region: PRK15027 909946011127 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 909946011128 N- and C-terminal domain interface [polypeptide binding]; other site 909946011129 active site 909946011130 MgATP binding site [chemical binding]; other site 909946011131 catalytic site [active] 909946011132 metal binding site [ion binding]; metal-binding site 909946011133 xylulose binding site [chemical binding]; other site 909946011134 homodimer interface [polypeptide binding]; other site 909946011135 xylose isomerase; Provisional; Region: PRK05474 909946011136 xylose isomerase; Region: xylose_isom_A; TIGR02630 909946011137 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 909946011138 putative dimerization interface [polypeptide binding]; other site 909946011139 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909946011140 putative ligand binding site [chemical binding]; other site 909946011141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946011142 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 909946011143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946011144 hypothetical protein; Provisional; Region: PRK10356 909946011145 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 909946011146 alpha-amylase; Reviewed; Region: malS; PRK09505 909946011147 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 909946011148 active site 909946011149 catalytic site [active] 909946011150 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 909946011151 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909946011152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946011153 homodimer interface [polypeptide binding]; other site 909946011154 catalytic residue [active] 909946011155 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 909946011156 Transcriptional regulator [Transcription]; Region: IclR; COG1414 909946011157 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 909946011158 Bacterial transcriptional regulator; Region: IclR; pfam01614 909946011159 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 909946011160 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 909946011161 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 909946011162 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 909946011163 DctM-like transporters; Region: DctM; pfam06808 909946011164 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 909946011165 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 909946011166 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 909946011167 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 909946011168 putative N- and C-terminal domain interface [polypeptide binding]; other site 909946011169 putative active site [active] 909946011170 MgATP binding site [chemical binding]; other site 909946011171 catalytic site [active] 909946011172 metal binding site [ion binding]; metal-binding site 909946011173 putative xylulose binding site [chemical binding]; other site 909946011174 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 909946011175 active site 909946011176 dimer interface [polypeptide binding]; other site 909946011177 magnesium binding site [ion binding]; other site 909946011178 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 909946011179 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 909946011180 AP (apurinic/apyrimidinic) site pocket; other site 909946011181 DNA interaction; other site 909946011182 Metal-binding active site; metal-binding site 909946011183 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 909946011184 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 909946011185 intersubunit interface [polypeptide binding]; other site 909946011186 active site 909946011187 Zn2+ binding site [ion binding]; other site 909946011188 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 909946011189 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 909946011190 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946011191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 909946011192 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 909946011193 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 909946011194 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 909946011195 NAD(P) binding site [chemical binding]; other site 909946011196 catalytic residues [active] 909946011197 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 909946011198 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 909946011199 nucleotide binding site [chemical binding]; other site 909946011200 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 909946011201 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 909946011202 G1 box; other site 909946011203 putative GEF interaction site [polypeptide binding]; other site 909946011204 GTP/Mg2+ binding site [chemical binding]; other site 909946011205 Switch I region; other site 909946011206 G2 box; other site 909946011207 G3 box; other site 909946011208 Switch II region; other site 909946011209 G4 box; other site 909946011210 G5 box; other site 909946011211 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 909946011212 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 909946011213 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 909946011214 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 909946011215 selenocysteine synthase; Provisional; Region: PRK04311 909946011216 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 909946011217 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 909946011218 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909946011219 catalytic residue [active] 909946011220 putative glutathione S-transferase; Provisional; Region: PRK10357 909946011221 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 909946011222 putative C-terminal domain interface [polypeptide binding]; other site 909946011223 putative GSH binding site (G-site) [chemical binding]; other site 909946011224 putative dimer interface [polypeptide binding]; other site 909946011225 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 909946011226 dimer interface [polypeptide binding]; other site 909946011227 N-terminal domain interface [polypeptide binding]; other site 909946011228 putative substrate binding pocket (H-site) [chemical binding]; other site 909946011229 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 909946011230 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 909946011231 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 909946011232 active site 909946011233 P-loop; other site 909946011234 phosphorylation site [posttranslational modification] 909946011235 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909946011236 active site 909946011237 phosphorylation site [posttranslational modification] 909946011238 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 909946011239 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 909946011240 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 909946011241 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 909946011242 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 909946011243 hypothetical protein; Provisional; Region: PRK11020 909946011244 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 909946011245 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 909946011246 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 909946011247 trimer interface [polypeptide binding]; other site 909946011248 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 909946011249 Haemagglutinin; Region: HIM; pfam05662 909946011250 Haemagglutinin; Region: HIM; pfam05662 909946011251 YadA-like C-terminal region; Region: YadA; pfam03895 909946011252 L-lactate permease; Provisional; Region: PRK10420 909946011253 glycolate transporter; Provisional; Region: PRK09695 909946011254 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 909946011255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946011256 DNA-binding site [nucleotide binding]; DNA binding site 909946011257 FCD domain; Region: FCD; pfam07729 909946011258 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 909946011259 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 909946011260 active site 909946011261 substrate binding site [chemical binding]; other site 909946011262 FMN binding site [chemical binding]; other site 909946011263 putative catalytic residues [active] 909946011264 putative rRNA methylase; Provisional; Region: PRK10358 909946011265 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909946011266 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946011267 DNA binding site [nucleotide binding] 909946011268 domain linker motif; other site 909946011269 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 909946011270 putative dimerization interface [polypeptide binding]; other site 909946011271 putative ligand binding site [chemical binding]; other site 909946011272 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 909946011273 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 909946011274 active site pocket [active] 909946011275 serine acetyltransferase; Provisional; Region: cysE; PRK11132 909946011276 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 909946011277 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 909946011278 trimer interface [polypeptide binding]; other site 909946011279 active site 909946011280 substrate binding site [chemical binding]; other site 909946011281 CoA binding site [chemical binding]; other site 909946011282 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 909946011283 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 909946011284 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 909946011285 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 909946011286 SecA binding site; other site 909946011287 Preprotein binding site; other site 909946011288 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 909946011289 GSH binding site [chemical binding]; other site 909946011290 catalytic residues [active] 909946011291 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 909946011292 active site residue [active] 909946011293 phosphoglyceromutase; Provisional; Region: PRK05434 909946011294 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 909946011295 AmiB activator; Provisional; Region: PRK11637 909946011296 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 909946011297 Peptidase family M23; Region: Peptidase_M23; pfam01551 909946011298 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 909946011299 NodB motif; other site 909946011300 putative active site [active] 909946011301 putative catalytic site [active] 909946011302 Zn binding site [ion binding]; other site 909946011303 putative glycosyl transferase; Provisional; Region: PRK10073 909946011304 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 909946011305 active site 909946011306 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 909946011307 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 909946011308 NAD(P) binding site [chemical binding]; other site 909946011309 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 909946011310 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 909946011311 substrate-cofactor binding pocket; other site 909946011312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946011313 catalytic residue [active] 909946011314 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 909946011315 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 909946011316 NADP binding site [chemical binding]; other site 909946011317 homopentamer interface [polypeptide binding]; other site 909946011318 substrate binding site [chemical binding]; other site 909946011319 active site 909946011320 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 909946011321 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 909946011322 putative active site [active] 909946011323 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 909946011324 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 909946011325 putative active site [active] 909946011326 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 909946011327 O-antigen ligase RfaL; Provisional; Region: PRK15487 909946011328 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 909946011329 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 909946011330 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 909946011331 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 909946011332 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 909946011333 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 909946011334 Ligand binding site; other site 909946011335 metal-binding site 909946011336 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 909946011337 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 909946011338 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 909946011339 Ligand binding site; other site 909946011340 metal-binding site 909946011341 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 909946011342 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 909946011343 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 909946011344 putative ADP-binding pocket [chemical binding]; other site 909946011345 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 909946011346 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 909946011347 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 909946011348 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 909946011349 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 909946011350 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 909946011351 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 909946011352 putative active site [active] 909946011353 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 909946011354 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 909946011355 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 909946011356 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 909946011357 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 909946011358 active site 909946011359 (T/H)XGH motif; other site 909946011360 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 909946011361 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 909946011362 DNA binding site [nucleotide binding] 909946011363 catalytic residue [active] 909946011364 H2TH interface [polypeptide binding]; other site 909946011365 putative catalytic residues [active] 909946011366 turnover-facilitating residue; other site 909946011367 intercalation triad [nucleotide binding]; other site 909946011368 8OG recognition residue [nucleotide binding]; other site 909946011369 putative reading head residues; other site 909946011370 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 909946011371 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 909946011372 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 909946011373 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 909946011374 hypothetical protein; Reviewed; Region: PRK00024 909946011375 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 909946011376 MPN+ (JAMM) motif; other site 909946011377 Zinc-binding site [ion binding]; other site 909946011378 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 909946011379 Flavoprotein; Region: Flavoprotein; pfam02441 909946011380 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 909946011381 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 909946011382 trimer interface [polypeptide binding]; other site 909946011383 active site 909946011384 division inhibitor protein; Provisional; Region: slmA; PRK09480 909946011385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946011386 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909946011387 active site 909946011388 ribonuclease PH; Reviewed; Region: rph; PRK00173 909946011389 Ribonuclease PH; Region: RNase_PH_bact; cd11362 909946011390 hexamer interface [polypeptide binding]; other site 909946011391 active site 909946011392 hypothetical protein; Provisional; Region: PRK11820 909946011393 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 909946011394 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 909946011395 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946011396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946011397 dimerization interface [polypeptide binding]; other site 909946011398 LysR substrate binding domain; Region: LysR_substrate; pfam03466 909946011399 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 909946011400 Predicted membrane protein [Function unknown]; Region: COG2860 909946011401 UPF0126 domain; Region: UPF0126; pfam03458 909946011402 UPF0126 domain; Region: UPF0126; pfam03458 909946011403 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 909946011404 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 909946011405 nucleotide binding pocket [chemical binding]; other site 909946011406 K-X-D-G motif; other site 909946011407 catalytic site [active] 909946011408 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 909946011409 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 909946011410 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 909946011411 catalytic site [active] 909946011412 G-X2-G-X-G-K; other site 909946011413 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 909946011414 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 909946011415 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 909946011416 Zn2+ binding site [ion binding]; other site 909946011417 Mg2+ binding site [ion binding]; other site 909946011418 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 909946011419 synthetase active site [active] 909946011420 NTP binding site [chemical binding]; other site 909946011421 metal binding site [ion binding]; metal-binding site 909946011422 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 909946011423 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 909946011424 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 909946011425 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 909946011426 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 909946011427 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 909946011428 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 909946011429 generic binding surface II; other site 909946011430 ssDNA binding site; other site 909946011431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909946011432 ATP binding site [chemical binding]; other site 909946011433 putative Mg++ binding site [ion binding]; other site 909946011434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946011435 nucleotide binding region [chemical binding]; other site 909946011436 ATP-binding site [chemical binding]; other site 909946011437 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 909946011438 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 909946011439 AsmA family; Region: AsmA; pfam05170 909946011440 putative alpha-glucosidase; Provisional; Region: PRK10658 909946011441 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 909946011442 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 909946011443 active site 909946011444 homotrimer interface [polypeptide binding]; other site 909946011445 catalytic site [active] 909946011446 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 909946011447 putative transporter; Provisional; Region: PRK11462 909946011448 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 909946011449 Virulence protein [General function prediction only]; Region: COG3943 909946011450 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 909946011451 autotransport protein MisL; Provisional; Region: PRK15313 909946011452 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 909946011453 Autotransporter beta-domain; Region: Autotransporter; pfam03797 909946011454 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 909946011455 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 909946011456 DNA binding site [nucleotide binding] 909946011457 Isochorismatase family; Region: Isochorismatase; pfam00857 909946011458 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 909946011459 catalytic triad [active] 909946011460 dimer interface [polypeptide binding]; other site 909946011461 conserved cis-peptide bond; other site 909946011462 magnesium-transporting ATPase; Provisional; Region: PRK15122 909946011463 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 909946011464 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 909946011465 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 909946011466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946011467 motif II; other site 909946011468 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 909946011469 magnesium transport protein MgtC; Provisional; Region: PRK15385 909946011470 MgtC family; Region: MgtC; pfam02308 909946011471 EamA-like transporter family; Region: EamA; pfam00892 909946011472 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 909946011473 EamA-like transporter family; Region: EamA; pfam00892 909946011474 hypothetical protein; Provisional; Region: PRK09956 909946011475 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 909946011476 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 909946011477 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 909946011478 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 909946011479 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 909946011480 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 909946011481 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 909946011482 active site 909946011483 phosphorylation site [posttranslational modification] 909946011484 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 909946011485 active pocket/dimerization site; other site 909946011486 active site 909946011487 phosphorylation site [posttranslational modification] 909946011488 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 909946011489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946011490 Walker A motif; other site 909946011491 ATP binding site [chemical binding]; other site 909946011492 Walker B motif; other site 909946011493 arginine finger; other site 909946011494 Transcriptional antiterminator [Transcription]; Region: COG3933 909946011495 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 909946011496 active site 909946011497 active pocket/dimerization site; other site 909946011498 phosphorylation site [posttranslational modification] 909946011499 PRD domain; Region: PRD; pfam00874 909946011500 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 909946011501 beta-galactosidase; Region: BGL; TIGR03356 909946011502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 909946011503 Predicted transcriptional regulator [Transcription]; Region: COG2944 909946011504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946011505 non-specific DNA binding site [nucleotide binding]; other site 909946011506 salt bridge; other site 909946011507 sequence-specific DNA binding site [nucleotide binding]; other site 909946011508 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 909946011509 dimerization domain swap beta strand [polypeptide binding]; other site 909946011510 regulatory protein interface [polypeptide binding]; other site 909946011511 active site 909946011512 regulatory phosphorylation site [posttranslational modification]; other site 909946011513 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 909946011514 intersubunit interface [polypeptide binding]; other site 909946011515 active site 909946011516 zinc binding site [ion binding]; other site 909946011517 Na+ binding site [ion binding]; other site 909946011518 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 909946011519 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 909946011520 putative N- and C-terminal domain interface [polypeptide binding]; other site 909946011521 putative active site [active] 909946011522 putative MgATP binding site [chemical binding]; other site 909946011523 catalytic site [active] 909946011524 metal binding site [ion binding]; metal-binding site 909946011525 putative carbohydrate binding site [chemical binding]; other site 909946011526 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 909946011527 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 909946011528 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 909946011529 active site 909946011530 P-loop; other site 909946011531 phosphorylation site [posttranslational modification] 909946011532 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909946011533 active site 909946011534 phosphorylation site [posttranslational modification] 909946011535 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 909946011536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946011537 DNA-binding site [nucleotide binding]; DNA binding site 909946011538 UTRA domain; Region: UTRA; pfam07702 909946011539 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 909946011540 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 909946011541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946011542 putative substrate translocation pore; other site 909946011543 regulatory protein UhpC; Provisional; Region: PRK11663 909946011544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946011545 putative substrate translocation pore; other site 909946011546 sensory histidine kinase UhpB; Provisional; Region: PRK11644 909946011547 MASE1; Region: MASE1; pfam05231 909946011548 Histidine kinase; Region: HisKA_3; pfam07730 909946011549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946011550 ATP binding site [chemical binding]; other site 909946011551 Mg2+ binding site [ion binding]; other site 909946011552 G-X-G motif; other site 909946011553 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 909946011554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946011555 active site 909946011556 phosphorylation site [posttranslational modification] 909946011557 intermolecular recognition site; other site 909946011558 dimerization interface [polypeptide binding]; other site 909946011559 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946011560 DNA binding residues [nucleotide binding] 909946011561 dimerization interface [polypeptide binding]; other site 909946011562 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 909946011563 active site 909946011564 catalytic residues [active] 909946011565 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 909946011566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946011567 putative substrate translocation pore; other site 909946011568 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909946011569 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 909946011570 substrate binding site [chemical binding]; other site 909946011571 dimer interface [polypeptide binding]; other site 909946011572 ATP binding site [chemical binding]; other site 909946011573 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 909946011574 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 909946011575 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946011576 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 909946011577 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 909946011578 putative valine binding site [chemical binding]; other site 909946011579 dimer interface [polypeptide binding]; other site 909946011580 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 909946011581 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 909946011582 PYR/PP interface [polypeptide binding]; other site 909946011583 dimer interface [polypeptide binding]; other site 909946011584 TPP binding site [chemical binding]; other site 909946011585 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 909946011586 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 909946011587 TPP-binding site [chemical binding]; other site 909946011588 dimer interface [polypeptide binding]; other site 909946011589 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 909946011590 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 909946011591 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 909946011592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946011593 putative substrate translocation pore; other site 909946011594 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 909946011595 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 909946011596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946011597 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 909946011598 dimerization interface [polypeptide binding]; other site 909946011599 substrate binding pocket [chemical binding]; other site 909946011600 permease DsdX; Provisional; Region: PRK09921 909946011601 gluconate transporter; Region: gntP; TIGR00791 909946011602 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 909946011603 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 909946011604 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909946011605 catalytic residue [active] 909946011606 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 909946011607 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 909946011608 Domain of unknown function (DUF202); Region: DUF202; pfam02656 909946011609 Predicted membrane protein [Function unknown]; Region: COG2149 909946011610 putative transporter; Validated; Region: PRK03818 909946011611 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 909946011612 TrkA-C domain; Region: TrkA_C; pfam02080 909946011613 TrkA-C domain; Region: TrkA_C; pfam02080 909946011614 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 909946011615 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 909946011616 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 909946011617 putative dimer interface [polypeptide binding]; other site 909946011618 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 909946011619 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 909946011620 putative dimer interface [polypeptide binding]; other site 909946011621 hypothetical protein; Provisional; Region: PRK11616 909946011622 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 909946011623 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 909946011624 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 909946011625 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 909946011626 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 909946011627 catalytic residues [active] 909946011628 central insert; other site 909946011629 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 909946011630 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 909946011631 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 909946011632 heme exporter protein CcmC; Region: ccmC; TIGR01191 909946011633 heme exporter protein CcmB; Region: ccmB; TIGR01190 909946011634 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 909946011635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946011636 Walker A/P-loop; other site 909946011637 ATP binding site [chemical binding]; other site 909946011638 Q-loop/lid; other site 909946011639 ABC transporter signature motif; other site 909946011640 Walker B; other site 909946011641 D-loop; other site 909946011642 H-loop/switch region; other site 909946011643 Haem-binding domain; Region: Haem_bd; pfam14376 909946011644 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 909946011645 chaperone protein TorD; Validated; Region: torD; PRK04976 909946011646 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 909946011647 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 909946011648 molybdopterin cofactor binding site [chemical binding]; other site 909946011649 substrate binding site [chemical binding]; other site 909946011650 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 909946011651 molybdopterin cofactor binding site; other site 909946011652 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 909946011653 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 909946011654 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 909946011655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946011656 active site 909946011657 phosphorylation site [posttranslational modification] 909946011658 intermolecular recognition site; other site 909946011659 dimerization interface [polypeptide binding]; other site 909946011660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946011661 DNA binding site [nucleotide binding] 909946011662 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 909946011663 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 909946011664 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 909946011665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946011666 dimer interface [polypeptide binding]; other site 909946011667 phosphorylation site [posttranslational modification] 909946011668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946011669 ATP binding site [chemical binding]; other site 909946011670 Mg2+ binding site [ion binding]; other site 909946011671 G-X-G motif; other site 909946011672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946011673 active site 909946011674 phosphorylation site [posttranslational modification] 909946011675 intermolecular recognition site; other site 909946011676 dimerization interface [polypeptide binding]; other site 909946011677 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 909946011678 putative binding surface; other site 909946011679 active site 909946011680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946011681 D-galactonate transporter; Region: 2A0114; TIGR00893 909946011682 putative substrate translocation pore; other site 909946011683 galactonate dehydratase; Provisional; Region: PRK14017 909946011684 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 909946011685 putative active site pocket [active] 909946011686 putative metal binding site [ion binding]; other site 909946011687 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 909946011688 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 909946011689 active site 909946011690 intersubunit interface [polypeptide binding]; other site 909946011691 catalytic residue [active] 909946011692 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 909946011693 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 909946011694 Transcriptional regulators [Transcription]; Region: FadR; COG2186 909946011695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946011696 DNA-binding site [nucleotide binding]; DNA binding site 909946011697 FCD domain; Region: FCD; pfam07729 909946011698 sugar phosphate phosphatase; Provisional; Region: PRK10513 909946011699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946011700 active site 909946011701 motif I; other site 909946011702 motif II; other site 909946011703 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946011704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946011705 D-galactonate transporter; Region: 2A0114; TIGR00893 909946011706 putative substrate translocation pore; other site 909946011707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946011708 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 909946011709 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 909946011710 active site pocket [active] 909946011711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946011712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946011713 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 909946011714 putative dimerization interface [polypeptide binding]; other site 909946011715 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 909946011716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946011717 Mg2+ binding site [ion binding]; other site 909946011718 G-X-G motif; other site 909946011719 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 909946011720 anchoring element; other site 909946011721 dimer interface [polypeptide binding]; other site 909946011722 ATP binding site [chemical binding]; other site 909946011723 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 909946011724 active site 909946011725 putative metal-binding site [ion binding]; other site 909946011726 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 909946011727 recF protein; Region: recf; TIGR00611 909946011728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946011729 Walker A/P-loop; other site 909946011730 ATP binding site [chemical binding]; other site 909946011731 Q-loop/lid; other site 909946011732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946011733 ABC transporter signature motif; other site 909946011734 Walker B; other site 909946011735 D-loop; other site 909946011736 H-loop/switch region; other site 909946011737 DNA polymerase III subunit beta; Validated; Region: PRK05643 909946011738 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 909946011739 putative DNA binding surface [nucleotide binding]; other site 909946011740 dimer interface [polypeptide binding]; other site 909946011741 beta-clamp/clamp loader binding surface; other site 909946011742 beta-clamp/translesion DNA polymerase binding surface; other site 909946011743 DnaA N-terminal domain; Region: DnaA_N; pfam11638 909946011744 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 909946011745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946011746 Walker A motif; other site 909946011747 ATP binding site [chemical binding]; other site 909946011748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 909946011749 Walker B motif; other site 909946011750 arginine finger; other site 909946011751 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 909946011752 DnaA box-binding interface [nucleotide binding]; other site 909946011753 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 909946011754 ribonuclease P; Reviewed; Region: rnpA; PRK01732 909946011755 hypothetical protein; Validated; Region: PRK00041 909946011756 membrane protein insertase; Provisional; Region: PRK01318 909946011757 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 909946011758 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 909946011759 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 909946011760 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 909946011761 trmE is a tRNA modification GTPase; Region: trmE; cd04164 909946011762 G1 box; other site 909946011763 GTP/Mg2+ binding site [chemical binding]; other site 909946011764 Switch I region; other site 909946011765 G2 box; other site 909946011766 Switch II region; other site 909946011767 G3 box; other site 909946011768 G4 box; other site 909946011769 G5 box; other site 909946011770 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 909946011771 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 909946011772 active site 909946011773 Int/Topo IB signature motif; other site 909946011774 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 909946011775 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 909946011776 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 909946011777 putative active site [active] 909946011778 putative NTP binding site [chemical binding]; other site 909946011779 putative nucleic acid binding site [nucleotide binding]; other site 909946011780 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 909946011781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946011782 putative substrate translocation pore; other site 909946011783 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 909946011784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946011785 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 909946011786 substrate binding pocket [chemical binding]; other site 909946011787 dimerization interface [polypeptide binding]; other site 909946011788 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 909946011789 Predicted flavoprotein [General function prediction only]; Region: COG0431 909946011790 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 909946011791 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 909946011792 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 909946011793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946011794 active site 909946011795 motif I; other site 909946011796 motif II; other site 909946011797 transcriptional regulator PhoU; Provisional; Region: PRK11115 909946011798 PhoU domain; Region: PhoU; pfam01895 909946011799 PhoU domain; Region: PhoU; pfam01895 909946011800 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 909946011801 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 909946011802 Walker A/P-loop; other site 909946011803 ATP binding site [chemical binding]; other site 909946011804 Q-loop/lid; other site 909946011805 ABC transporter signature motif; other site 909946011806 Walker B; other site 909946011807 D-loop; other site 909946011808 H-loop/switch region; other site 909946011809 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 909946011810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946011811 dimer interface [polypeptide binding]; other site 909946011812 conserved gate region; other site 909946011813 putative PBP binding loops; other site 909946011814 ABC-ATPase subunit interface; other site 909946011815 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 909946011816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946011817 dimer interface [polypeptide binding]; other site 909946011818 conserved gate region; other site 909946011819 putative PBP binding loops; other site 909946011820 ABC-ATPase subunit interface; other site 909946011821 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946011822 substrate binding pocket [chemical binding]; other site 909946011823 membrane-bound complex binding site; other site 909946011824 hinge residues; other site 909946011825 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 909946011826 active site 909946011827 P-loop; other site 909946011828 phosphorylation site [posttranslational modification] 909946011829 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 909946011830 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 909946011831 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 909946011832 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 909946011833 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 909946011834 shikimate binding site; other site 909946011835 NAD(P) binding site [chemical binding]; other site 909946011836 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 909946011837 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 909946011838 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 909946011839 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 909946011840 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 909946011841 glutaminase active site [active] 909946011842 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 909946011843 dimer interface [polypeptide binding]; other site 909946011844 active site 909946011845 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 909946011846 dimer interface [polypeptide binding]; other site 909946011847 active site 909946011848 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 909946011849 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 909946011850 Substrate binding site; other site 909946011851 Mg++ binding site; other site 909946011852 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 909946011853 active site 909946011854 substrate binding site [chemical binding]; other site 909946011855 CoA binding site [chemical binding]; other site 909946011856 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 909946011857 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 909946011858 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 909946011859 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 909946011860 gamma subunit interface [polypeptide binding]; other site 909946011861 epsilon subunit interface [polypeptide binding]; other site 909946011862 LBP interface [polypeptide binding]; other site 909946011863 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 909946011864 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 909946011865 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 909946011866 alpha subunit interaction interface [polypeptide binding]; other site 909946011867 Walker A motif; other site 909946011868 ATP binding site [chemical binding]; other site 909946011869 Walker B motif; other site 909946011870 inhibitor binding site; inhibition site 909946011871 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 909946011872 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 909946011873 core domain interface [polypeptide binding]; other site 909946011874 delta subunit interface [polypeptide binding]; other site 909946011875 epsilon subunit interface [polypeptide binding]; other site 909946011876 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 909946011877 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 909946011878 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 909946011879 beta subunit interaction interface [polypeptide binding]; other site 909946011880 Walker A motif; other site 909946011881 ATP binding site [chemical binding]; other site 909946011882 Walker B motif; other site 909946011883 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 909946011884 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 909946011885 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 909946011886 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 909946011887 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 909946011888 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 909946011889 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 909946011890 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 909946011891 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 909946011892 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 909946011893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946011894 S-adenosylmethionine binding site [chemical binding]; other site 909946011895 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 909946011896 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 909946011897 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 909946011898 FMN-binding protein MioC; Provisional; Region: PRK09004 909946011899 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 909946011900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909946011901 putative DNA binding site [nucleotide binding]; other site 909946011902 putative Zn2+ binding site [ion binding]; other site 909946011903 AsnC family; Region: AsnC_trans_reg; pfam01037 909946011904 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 909946011905 dimer interface [polypeptide binding]; other site 909946011906 active site 909946011907 hypothetical protein; Provisional; Region: yieM; PRK10997 909946011908 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 909946011909 metal ion-dependent adhesion site (MIDAS); other site 909946011910 regulatory ATPase RavA; Provisional; Region: PRK13531 909946011911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946011912 Walker A motif; other site 909946011913 ATP binding site [chemical binding]; other site 909946011914 Walker B motif; other site 909946011915 arginine finger; other site 909946011916 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 909946011917 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 909946011918 potassium uptake protein; Region: kup; TIGR00794 909946011919 D-ribose pyranase; Provisional; Region: PRK11797 909946011920 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 909946011921 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 909946011922 Walker A/P-loop; other site 909946011923 ATP binding site [chemical binding]; other site 909946011924 Q-loop/lid; other site 909946011925 ABC transporter signature motif; other site 909946011926 Walker B; other site 909946011927 D-loop; other site 909946011928 H-loop/switch region; other site 909946011929 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 909946011930 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 909946011931 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 909946011932 TM-ABC transporter signature motif; other site 909946011933 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 909946011934 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 909946011935 ligand binding site [chemical binding]; other site 909946011936 dimerization interface [polypeptide binding]; other site 909946011937 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909946011938 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 909946011939 substrate binding site [chemical binding]; other site 909946011940 dimer interface [polypeptide binding]; other site 909946011941 ATP binding site [chemical binding]; other site 909946011942 transcriptional repressor RbsR; Provisional; Region: PRK10423 909946011943 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946011944 DNA binding site [nucleotide binding] 909946011945 domain linker motif; other site 909946011946 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 909946011947 dimerization interface [polypeptide binding]; other site 909946011948 ligand binding site [chemical binding]; other site 909946011949 Transcriptional regulators [Transcription]; Region: FadR; COG2186 909946011950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946011951 DNA-binding site [nucleotide binding]; DNA binding site 909946011952 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 909946011953 transcriptional regulator HdfR; Provisional; Region: PRK03601 909946011954 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946011955 LysR substrate binding domain; Region: LysR_substrate; pfam03466 909946011956 dimerization interface [polypeptide binding]; other site 909946011957 hypothetical protein; Provisional; Region: PRK11027 909946011958 putative ATP-dependent protease; Provisional; Region: PRK09862 909946011959 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 909946011960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946011961 Walker A motif; other site 909946011962 ATP binding site [chemical binding]; other site 909946011963 Walker B motif; other site 909946011964 arginine finger; other site 909946011965 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 909946011966 ilvG operon leader peptide; Provisional; Region: PRK10424 909946011967 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 909946011968 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 909946011969 PYR/PP interface [polypeptide binding]; other site 909946011970 dimer interface [polypeptide binding]; other site 909946011971 TPP binding site [chemical binding]; other site 909946011972 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 909946011973 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 909946011974 TPP-binding site [chemical binding]; other site 909946011975 dimer interface [polypeptide binding]; other site 909946011976 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 909946011977 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 909946011978 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 909946011979 homodimer interface [polypeptide binding]; other site 909946011980 substrate-cofactor binding pocket; other site 909946011981 catalytic residue [active] 909946011982 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 909946011983 threonine dehydratase; Reviewed; Region: PRK09224 909946011984 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 909946011985 tetramer interface [polypeptide binding]; other site 909946011986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946011987 catalytic residue [active] 909946011988 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 909946011989 putative Ile/Val binding site [chemical binding]; other site 909946011990 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 909946011991 putative Ile/Val binding site [chemical binding]; other site 909946011992 Phage-related protein [Function unknown]; Region: COG4679 909946011993 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 909946011994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946011995 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 909946011996 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 909946011997 putative dimerization interface [polypeptide binding]; other site 909946011998 ketol-acid reductoisomerase; Validated; Region: PRK05225 909946011999 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 909946012000 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 909946012001 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 909946012002 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 909946012003 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 909946012004 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 909946012005 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 909946012006 Part of AAA domain; Region: AAA_19; pfam13245 909946012007 Family description; Region: UvrD_C_2; pfam13538 909946012008 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 909946012009 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 909946012010 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 909946012011 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 909946012012 ATP binding site [chemical binding]; other site 909946012013 Mg++ binding site [ion binding]; other site 909946012014 motif III; other site 909946012015 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946012016 nucleotide binding region [chemical binding]; other site 909946012017 ATP-binding site [chemical binding]; other site 909946012018 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 909946012019 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 909946012020 catalytic residues [active] 909946012021 transcription termination factor Rho; Provisional; Region: rho; PRK09376 909946012022 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 909946012023 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 909946012024 RNA binding site [nucleotide binding]; other site 909946012025 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 909946012026 multimer interface [polypeptide binding]; other site 909946012027 Walker A motif; other site 909946012028 ATP binding site [chemical binding]; other site 909946012029 Walker B motif; other site 909946012030 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 909946012031 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 909946012032 Mg++ binding site [ion binding]; other site 909946012033 putative catalytic motif [active] 909946012034 substrate binding site [chemical binding]; other site 909946012035 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 909946012036 Chain length determinant protein; Region: Wzz; pfam02706 909946012037 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 909946012038 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 909946012039 active site 909946012040 homodimer interface [polypeptide binding]; other site 909946012041 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 909946012042 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 909946012043 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 909946012044 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 909946012045 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 909946012046 NAD binding site [chemical binding]; other site 909946012047 substrate binding site [chemical binding]; other site 909946012048 homodimer interface [polypeptide binding]; other site 909946012049 active site 909946012050 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 909946012051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 909946012052 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 909946012053 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 909946012054 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 909946012055 inhibitor-cofactor binding pocket; inhibition site 909946012056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946012057 catalytic residue [active] 909946012058 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 909946012059 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 909946012060 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 909946012061 putative common antigen polymerase; Provisional; Region: PRK02975 909946012062 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 909946012063 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 909946012064 putative transport protein YifK; Provisional; Region: PRK10746 909946012065 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 909946012066 HemY protein N-terminus; Region: HemY_N; pfam07219 909946012067 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 909946012068 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 909946012069 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 909946012070 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 909946012071 active site 909946012072 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 909946012073 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 909946012074 domain interfaces; other site 909946012075 active site 909946012076 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 909946012077 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 909946012078 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 909946012079 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 909946012080 putative iron binding site [ion binding]; other site 909946012081 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 909946012082 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 909946012083 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 909946012084 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 909946012085 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 909946012086 hypothetical protein; Provisional; Region: PRK10963 909946012087 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 909946012088 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 909946012089 active site 909946012090 Int/Topo IB signature motif; other site 909946012091 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 909946012092 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946012093 motif II; other site 909946012094 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 909946012095 Part of AAA domain; Region: AAA_19; pfam13245 909946012096 Family description; Region: UvrD_C_2; pfam13538 909946012097 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 909946012098 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 909946012099 Cl binding site [ion binding]; other site 909946012100 oligomer interface [polypeptide binding]; other site 909946012101 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 909946012102 hypothetical protein; Provisional; Region: PRK11371 909946012103 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 909946012104 EamA-like transporter family; Region: EamA; cl17759 909946012105 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 909946012106 CoenzymeA binding site [chemical binding]; other site 909946012107 subunit interaction site [polypeptide binding]; other site 909946012108 PHB binding site; other site 909946012109 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 909946012110 dimerization interface [polypeptide binding]; other site 909946012111 substrate binding site [chemical binding]; other site 909946012112 active site 909946012113 calcium binding site [ion binding]; other site 909946012114 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 909946012115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909946012116 ATP binding site [chemical binding]; other site 909946012117 putative Mg++ binding site [ion binding]; other site 909946012118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909946012119 nucleotide binding region [chemical binding]; other site 909946012120 ATP-binding site [chemical binding]; other site 909946012121 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 909946012122 Helicase and RNase D C-terminal; Region: HRDC; smart00341 909946012123 threonine efflux system; Provisional; Region: PRK10229 909946012124 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 909946012125 lysophospholipase L2; Provisional; Region: PRK10749 909946012126 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 909946012127 putative hydrolase; Provisional; Region: PRK10976 909946012128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946012129 active site 909946012130 motif I; other site 909946012131 motif II; other site 909946012132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946012133 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 909946012134 EamA-like transporter family; Region: EamA; pfam00892 909946012135 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 909946012136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946012137 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 909946012138 putative dimerization interface [polypeptide binding]; other site 909946012139 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 909946012140 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 909946012141 THF binding site; other site 909946012142 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 909946012143 substrate binding site [chemical binding]; other site 909946012144 THF binding site; other site 909946012145 zinc-binding site [ion binding]; other site 909946012146 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 909946012147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946012148 FeS/SAM binding site; other site 909946012149 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 909946012150 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 909946012151 uridine phosphorylase; Provisional; Region: PRK11178 909946012152 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 909946012153 DNA recombination protein RmuC; Provisional; Region: PRK10361 909946012154 RmuC family; Region: RmuC; pfam02646 909946012155 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 909946012156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946012157 S-adenosylmethionine binding site [chemical binding]; other site 909946012158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 909946012159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 909946012160 SCP-2 sterol transfer family; Region: SCP2; pfam02036 909946012161 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 909946012162 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 909946012163 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 909946012164 sec-independent translocase; Provisional; Region: PRK01770 909946012165 sec-independent translocase; Provisional; Region: tatB; PRK00404 909946012166 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 909946012167 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 909946012168 active site 909946012169 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 909946012170 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 909946012171 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 909946012172 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 909946012173 FMN reductase; Validated; Region: fre; PRK08051 909946012174 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 909946012175 FAD binding pocket [chemical binding]; other site 909946012176 FAD binding motif [chemical binding]; other site 909946012177 phosphate binding motif [ion binding]; other site 909946012178 beta-alpha-beta structure motif; other site 909946012179 NAD binding pocket [chemical binding]; other site 909946012180 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 909946012181 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 909946012182 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 909946012183 dimer interface [polypeptide binding]; other site 909946012184 active site 909946012185 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 909946012186 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 909946012187 substrate binding site [chemical binding]; other site 909946012188 oxyanion hole (OAH) forming residues; other site 909946012189 trimer interface [polypeptide binding]; other site 909946012190 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 909946012191 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 909946012192 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 909946012193 proline dipeptidase; Provisional; Region: PRK13607 909946012194 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 909946012195 active site 909946012196 hypothetical protein; Provisional; Region: PRK11568 909946012197 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 909946012198 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 909946012199 potassium transporter; Provisional; Region: PRK10750 909946012200 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 909946012201 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 909946012202 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 909946012203 Walker A motif; other site 909946012204 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 909946012205 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 909946012206 GTP binding site; other site 909946012207 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 909946012208 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 909946012209 serine/threonine protein kinase; Provisional; Region: PRK11768 909946012210 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 909946012211 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 909946012212 catalytic residues [active] 909946012213 hinge region; other site 909946012214 alpha helical domain; other site 909946012215 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 909946012216 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 909946012217 putative acyl-acceptor binding pocket; other site 909946012218 DNA polymerase I; Provisional; Region: PRK05755 909946012219 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 909946012220 active site 909946012221 metal binding site 1 [ion binding]; metal-binding site 909946012222 putative 5' ssDNA interaction site; other site 909946012223 metal binding site 3; metal-binding site 909946012224 metal binding site 2 [ion binding]; metal-binding site 909946012225 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 909946012226 putative DNA binding site [nucleotide binding]; other site 909946012227 putative metal binding site [ion binding]; other site 909946012228 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 909946012229 active site 909946012230 catalytic site [active] 909946012231 substrate binding site [chemical binding]; other site 909946012232 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 909946012233 active site 909946012234 DNA binding site [nucleotide binding] 909946012235 catalytic site [active] 909946012236 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 909946012237 G1 box; other site 909946012238 GTP/Mg2+ binding site [chemical binding]; other site 909946012239 Switch I region; other site 909946012240 G2 box; other site 909946012241 G3 box; other site 909946012242 Switch II region; other site 909946012243 G4 box; other site 909946012244 G5 box; other site 909946012245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 909946012246 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 909946012247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946012248 FeS/SAM binding site; other site 909946012249 HemN C-terminal domain; Region: HemN_C; pfam06969 909946012250 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 909946012251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946012252 active site 909946012253 phosphorylation site [posttranslational modification] 909946012254 intermolecular recognition site; other site 909946012255 dimerization interface [polypeptide binding]; other site 909946012256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946012257 Walker A motif; other site 909946012258 ATP binding site [chemical binding]; other site 909946012259 Walker B motif; other site 909946012260 arginine finger; other site 909946012261 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 909946012262 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 909946012263 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 909946012264 putative active site [active] 909946012265 heme pocket [chemical binding]; other site 909946012266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946012267 dimer interface [polypeptide binding]; other site 909946012268 phosphorylation site [posttranslational modification] 909946012269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946012270 ATP binding site [chemical binding]; other site 909946012271 Mg2+ binding site [ion binding]; other site 909946012272 G-X-G motif; other site 909946012273 glutamine synthetase; Provisional; Region: glnA; PRK09469 909946012274 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 909946012275 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 909946012276 GTP-binding protein; Provisional; Region: PRK10218 909946012277 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 909946012278 G1 box; other site 909946012279 putative GEF interaction site [polypeptide binding]; other site 909946012280 GTP/Mg2+ binding site [chemical binding]; other site 909946012281 Switch I region; other site 909946012282 G2 box; other site 909946012283 G3 box; other site 909946012284 Switch II region; other site 909946012285 G4 box; other site 909946012286 G5 box; other site 909946012287 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 909946012288 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 909946012289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946012290 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 909946012291 active site 909946012292 motif I; other site 909946012293 motif II; other site 909946012294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946012295 coproporphyrinogen III oxidase; Validated; Region: PRK08208 909946012296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946012297 FeS/SAM binding site; other site 909946012298 HemN C-terminal domain; Region: HemN_C; pfam06969 909946012299 Sulfatase; Region: Sulfatase; cl17466 909946012300 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 909946012301 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 909946012302 Substrate binding site [chemical binding]; other site 909946012303 outer membrane porin L; Provisional; Region: ompL; PRK09980 909946012304 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 909946012305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946012306 putative substrate translocation pore; other site 909946012307 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 909946012308 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 909946012309 alpha-glucosidase; Provisional; Region: PRK10426 909946012310 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 909946012311 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 909946012312 putative active site [active] 909946012313 putative catalytic site [active] 909946012314 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 909946012315 active site 909946012316 catalytic residues [active] 909946012317 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 909946012318 dimerization interface [polypeptide binding]; other site 909946012319 putative active cleft [active] 909946012320 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 909946012321 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 909946012322 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 909946012323 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909946012324 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 909946012325 substrate binding site [chemical binding]; other site 909946012326 ATP binding site [chemical binding]; other site 909946012327 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909946012328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909946012329 putative DNA binding site [nucleotide binding]; other site 909946012330 putative Zn2+ binding site [ion binding]; other site 909946012331 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946012332 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 909946012333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946012334 motif II; other site 909946012335 hypothetical protein; Reviewed; Region: PRK01637 909946012336 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 909946012337 putative active site [active] 909946012338 dimerization interface [polypeptide binding]; other site 909946012339 putative tRNAtyr binding site [nucleotide binding]; other site 909946012340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946012341 Coenzyme A binding pocket [chemical binding]; other site 909946012342 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 909946012343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946012344 non-specific DNA binding site [nucleotide binding]; other site 909946012345 salt bridge; other site 909946012346 sequence-specific DNA binding site [nucleotide binding]; other site 909946012347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 909946012348 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 909946012349 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 909946012350 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 909946012351 Predicted transcriptional regulator [Transcription]; Region: COG2944 909946012352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946012353 non-specific DNA binding site [nucleotide binding]; other site 909946012354 salt bridge; other site 909946012355 sequence-specific DNA binding site [nucleotide binding]; other site 909946012356 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 909946012357 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 909946012358 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 909946012359 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 909946012360 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 909946012361 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 909946012362 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 909946012363 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 909946012364 [4Fe-4S] binding site [ion binding]; other site 909946012365 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 909946012366 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 909946012367 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 909946012368 molybdopterin cofactor binding site; other site 909946012369 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 909946012370 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 909946012371 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 909946012372 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 909946012373 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 909946012374 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 909946012375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946012376 non-specific DNA binding site [nucleotide binding]; other site 909946012377 salt bridge; other site 909946012378 sequence-specific DNA binding site [nucleotide binding]; other site 909946012379 Cupin domain; Region: Cupin_2; cl17218 909946012380 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 909946012381 lactaldehyde reductase; Region: lactal_redase; TIGR02638 909946012382 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 909946012383 dimer interface [polypeptide binding]; other site 909946012384 active site 909946012385 metal binding site [ion binding]; metal-binding site 909946012386 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 909946012387 intersubunit interface [polypeptide binding]; other site 909946012388 active site 909946012389 Zn2+ binding site [ion binding]; other site 909946012390 L-rhamnose isomerase; Provisional; Region: PRK01076 909946012391 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 909946012392 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 909946012393 N- and C-terminal domain interface [polypeptide binding]; other site 909946012394 active site 909946012395 putative catalytic site [active] 909946012396 metal binding site [ion binding]; metal-binding site 909946012397 ATP binding site [chemical binding]; other site 909946012398 rhamnulokinase; Provisional; Region: rhaB; PRK10640 909946012399 carbohydrate binding site [chemical binding]; other site 909946012400 transcriptional activator RhaS; Provisional; Region: PRK13503 909946012401 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 909946012402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946012403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946012404 transcriptional activator RhaR; Provisional; Region: PRK13502 909946012405 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 909946012406 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946012407 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 909946012408 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 909946012409 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 909946012410 DctM-like transporters; Region: DctM; pfam06808 909946012411 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 909946012412 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 909946012413 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 909946012414 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 909946012415 superoxide dismutase; Provisional; Region: PRK10925 909946012416 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 909946012417 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 909946012418 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 909946012419 MOSC domain; Region: MOSC; pfam03473 909946012420 3-alpha domain; Region: 3-alpha; pfam03475 909946012421 SnoaL-like domain; Region: SnoaL_2; pfam12680 909946012422 two-component sensor protein; Provisional; Region: cpxA; PRK09470 909946012423 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946012424 dimerization interface [polypeptide binding]; other site 909946012425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946012426 dimer interface [polypeptide binding]; other site 909946012427 phosphorylation site [posttranslational modification] 909946012428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946012429 ATP binding site [chemical binding]; other site 909946012430 Mg2+ binding site [ion binding]; other site 909946012431 G-X-G motif; other site 909946012432 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 909946012433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946012434 active site 909946012435 intermolecular recognition site; other site 909946012436 dimerization interface [polypeptide binding]; other site 909946012437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946012438 DNA binding site [nucleotide binding] 909946012439 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 909946012440 dimer interface [polypeptide binding]; other site 909946012441 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 909946012442 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 909946012443 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 909946012444 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 909946012445 active site 909946012446 ADP/pyrophosphate binding site [chemical binding]; other site 909946012447 dimerization interface [polypeptide binding]; other site 909946012448 allosteric effector site; other site 909946012449 fructose-1,6-bisphosphate binding site; other site 909946012450 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 909946012451 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946012452 substrate binding pocket [chemical binding]; other site 909946012453 membrane-bound complex binding site; other site 909946012454 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 909946012455 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 909946012456 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 909946012457 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909946012458 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 909946012459 putative substrate binding site [chemical binding]; other site 909946012460 putative ATP binding site [chemical binding]; other site 909946012461 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 909946012462 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 909946012463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946012464 DNA-binding site [nucleotide binding]; DNA binding site 909946012465 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 909946012466 UTRA domain; Region: UTRA; pfam07702 909946012467 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 909946012468 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 909946012469 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 909946012470 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 909946012471 putative N- and C-terminal domain interface [polypeptide binding]; other site 909946012472 putative active site [active] 909946012473 putative MgATP binding site [chemical binding]; other site 909946012474 catalytic site [active] 909946012475 metal binding site [ion binding]; metal-binding site 909946012476 putative carbohydrate binding site [chemical binding]; other site 909946012477 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 909946012478 transcriptional regulator LsrR; Provisional; Region: PRK15418 909946012479 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 909946012480 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 909946012481 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 909946012482 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 909946012483 Walker A/P-loop; other site 909946012484 ATP binding site [chemical binding]; other site 909946012485 Q-loop/lid; other site 909946012486 ABC transporter signature motif; other site 909946012487 Walker B; other site 909946012488 D-loop; other site 909946012489 H-loop/switch region; other site 909946012490 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 909946012491 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 909946012492 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 909946012493 TM-ABC transporter signature motif; other site 909946012494 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 909946012495 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 909946012496 TM-ABC transporter signature motif; other site 909946012497 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 909946012498 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 909946012499 ligand binding site [chemical binding]; other site 909946012500 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 909946012501 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 909946012502 putative active site; other site 909946012503 catalytic residue [active] 909946012504 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 909946012505 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 909946012506 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 909946012507 substrate binding site [chemical binding]; other site 909946012508 hexamer interface [polypeptide binding]; other site 909946012509 metal binding site [ion binding]; metal-binding site 909946012510 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 909946012511 triosephosphate isomerase; Provisional; Region: PRK14567 909946012512 substrate binding site [chemical binding]; other site 909946012513 dimer interface [polypeptide binding]; other site 909946012514 catalytic triad [active] 909946012515 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 909946012516 Predicted membrane protein [Function unknown]; Region: COG3152 909946012517 ferredoxin-NADP reductase; Provisional; Region: PRK10926 909946012518 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 909946012519 FAD binding pocket [chemical binding]; other site 909946012520 FAD binding motif [chemical binding]; other site 909946012521 phosphate binding motif [ion binding]; other site 909946012522 beta-alpha-beta structure motif; other site 909946012523 NAD binding pocket [chemical binding]; other site 909946012524 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 909946012525 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 909946012526 putative active site [active] 909946012527 glycerol kinase; Provisional; Region: glpK; PRK00047 909946012528 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 909946012529 N- and C-terminal domain interface [polypeptide binding]; other site 909946012530 active site 909946012531 MgATP binding site [chemical binding]; other site 909946012532 catalytic site [active] 909946012533 metal binding site [ion binding]; metal-binding site 909946012534 glycerol binding site [chemical binding]; other site 909946012535 homotetramer interface [polypeptide binding]; other site 909946012536 homodimer interface [polypeptide binding]; other site 909946012537 FBP binding site [chemical binding]; other site 909946012538 protein IIAGlc interface [polypeptide binding]; other site 909946012539 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 909946012540 amphipathic channel; other site 909946012541 Asn-Pro-Ala signature motifs; other site 909946012542 septal ring assembly protein ZapB; Provisional; Region: PRK15422 909946012543 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 909946012544 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 909946012545 UbiA prenyltransferase family; Region: UbiA; pfam01040 909946012546 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 909946012547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946012548 Walker A motif; other site 909946012549 ATP binding site [chemical binding]; other site 909946012550 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 909946012551 Walker B motif; other site 909946012552 arginine finger; other site 909946012553 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 909946012554 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 909946012555 active site 909946012556 HslU subunit interaction site [polypeptide binding]; other site 909946012557 essential cell division protein FtsN; Provisional; Region: PRK10927 909946012558 cell division protein FtsN; Provisional; Region: PRK12757 909946012559 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946012560 DNA binding site [nucleotide binding] 909946012561 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 909946012562 domain linker motif; other site 909946012563 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 909946012564 dimerization interface [polypeptide binding]; other site 909946012565 ligand binding site [chemical binding]; other site 909946012566 primosome assembly protein PriA; Validated; Region: PRK05580 909946012567 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909946012568 ATP binding site [chemical binding]; other site 909946012569 putative Mg++ binding site [ion binding]; other site 909946012570 helicase superfamily c-terminal domain; Region: HELICc; smart00490 909946012571 ATP-binding site [chemical binding]; other site 909946012572 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 909946012573 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 909946012574 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 909946012575 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 909946012576 dimerization interface [polypeptide binding]; other site 909946012577 DNA binding site [nucleotide binding] 909946012578 corepressor binding sites; other site 909946012579 cystathionine gamma-synthase; Provisional; Region: PRK08045 909946012580 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 909946012581 homodimer interface [polypeptide binding]; other site 909946012582 substrate-cofactor binding pocket; other site 909946012583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946012584 catalytic residue [active] 909946012585 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 909946012586 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 909946012587 putative catalytic residues [active] 909946012588 putative nucleotide binding site [chemical binding]; other site 909946012589 putative aspartate binding site [chemical binding]; other site 909946012590 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 909946012591 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 909946012592 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 909946012593 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 909946012594 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 909946012595 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 909946012596 active site 909946012597 metal binding site [ion binding]; metal-binding site 909946012598 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 909946012599 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 909946012600 FAD binding site [chemical binding]; other site 909946012601 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 909946012602 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 909946012603 heme binding site [chemical binding]; other site 909946012604 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 909946012605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 909946012606 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 909946012607 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 909946012608 dimer interface [polypeptide binding]; other site 909946012609 active site 909946012610 metal binding site [ion binding]; metal-binding site 909946012611 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 909946012612 active site 909946012613 intersubunit interactions; other site 909946012614 catalytic residue [active] 909946012615 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 909946012616 dimerization domain swap beta strand [polypeptide binding]; other site 909946012617 regulatory protein interface [polypeptide binding]; other site 909946012618 active site 909946012619 regulatory phosphorylation site [posttranslational modification]; other site 909946012620 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 909946012621 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 909946012622 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 909946012623 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 909946012624 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909946012625 active site 909946012626 phosphorylation site [posttranslational modification] 909946012627 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 909946012628 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 909946012629 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 909946012630 active site 909946012631 P-loop; other site 909946012632 phosphorylation site [posttranslational modification] 909946012633 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 909946012634 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 909946012635 dimer interface [polypeptide binding]; other site 909946012636 active site 909946012637 glycine loop; other site 909946012638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946012639 FeS/SAM binding site; other site 909946012640 pyruvate formate lyase II activase; Provisional; Region: PRK10076 909946012641 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 909946012642 active site 909946012643 P-loop; other site 909946012644 phosphorylation site [posttranslational modification] 909946012645 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 909946012646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946012647 hypothetical protein; Provisional; Region: PRK10649 909946012648 Sulfatase; Region: Sulfatase; pfam00884 909946012649 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 909946012650 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 909946012651 acetylornithine deacetylase; Provisional; Region: PRK05111 909946012652 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 909946012653 metal binding site [ion binding]; metal-binding site 909946012654 putative dimer interface [polypeptide binding]; other site 909946012655 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 909946012656 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 909946012657 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 909946012658 nucleotide binding site [chemical binding]; other site 909946012659 N-acetyl-L-glutamate binding site [chemical binding]; other site 909946012660 argininosuccinate lyase; Provisional; Region: PRK04833 909946012661 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 909946012662 active sites [active] 909946012663 tetramer interface [polypeptide binding]; other site 909946012664 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 909946012665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946012666 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 909946012667 dimerization interface [polypeptide binding]; other site 909946012668 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 909946012669 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909946012670 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 909946012671 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 909946012672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946012673 hypothetical protein; Provisional; Region: PRK11056 909946012674 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 909946012675 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 909946012676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946012677 S-adenosylmethionine binding site [chemical binding]; other site 909946012678 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 909946012679 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 909946012680 N-terminal plug; other site 909946012681 ligand-binding site [chemical binding]; other site 909946012682 glutamate racemase; Provisional; Region: PRK00865 909946012683 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 909946012684 FAD binding domain; Region: FAD_binding_4; pfam01565 909946012685 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 909946012686 Biotin operon repressor [Transcription]; Region: BirA; COG1654 909946012687 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 909946012688 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 909946012689 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 909946012690 pantothenate kinase; Provisional; Region: PRK05439 909946012691 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 909946012692 ATP-binding site [chemical binding]; other site 909946012693 CoA-binding site [chemical binding]; other site 909946012694 Mg2+-binding site [ion binding]; other site 909946012695 elongation factor Tu; Reviewed; Region: PRK00049 909946012696 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 909946012697 G1 box; other site 909946012698 GEF interaction site [polypeptide binding]; other site 909946012699 GTP/Mg2+ binding site [chemical binding]; other site 909946012700 Switch I region; other site 909946012701 G2 box; other site 909946012702 G3 box; other site 909946012703 Switch II region; other site 909946012704 G4 box; other site 909946012705 G5 box; other site 909946012706 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 909946012707 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 909946012708 Antibiotic Binding Site [chemical binding]; other site 909946012709 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 909946012710 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 909946012711 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 909946012712 putative homodimer interface [polypeptide binding]; other site 909946012713 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 909946012714 heterodimer interface [polypeptide binding]; other site 909946012715 homodimer interface [polypeptide binding]; other site 909946012716 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 909946012717 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 909946012718 23S rRNA interface [nucleotide binding]; other site 909946012719 L7/L12 interface [polypeptide binding]; other site 909946012720 putative thiostrepton binding site; other site 909946012721 L25 interface [polypeptide binding]; other site 909946012722 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 909946012723 mRNA/rRNA interface [nucleotide binding]; other site 909946012724 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 909946012725 23S rRNA interface [nucleotide binding]; other site 909946012726 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 909946012727 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 909946012728 core dimer interface [polypeptide binding]; other site 909946012729 peripheral dimer interface [polypeptide binding]; other site 909946012730 L10 interface [polypeptide binding]; other site 909946012731 L11 interface [polypeptide binding]; other site 909946012732 putative EF-Tu interaction site [polypeptide binding]; other site 909946012733 putative EF-G interaction site [polypeptide binding]; other site 909946012734 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 909946012735 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 909946012736 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 909946012737 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 909946012738 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 909946012739 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 909946012740 RPB3 interaction site [polypeptide binding]; other site 909946012741 RPB1 interaction site [polypeptide binding]; other site 909946012742 RPB11 interaction site [polypeptide binding]; other site 909946012743 RPB10 interaction site [polypeptide binding]; other site 909946012744 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 909946012745 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 909946012746 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 909946012747 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 909946012748 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 909946012749 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 909946012750 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 909946012751 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 909946012752 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 909946012753 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 909946012754 DNA binding site [nucleotide binding] 909946012755 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 909946012756 type III secretion system protein; Provisional; Region: PRK15384 909946012757 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 909946012758 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 909946012759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946012760 FeS/SAM binding site; other site 909946012761 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 909946012762 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 909946012763 ThiS interaction site; other site 909946012764 putative active site [active] 909946012765 tetramer interface [polypeptide binding]; other site 909946012766 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 909946012767 thiS-thiF/thiG interaction site; other site 909946012768 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 909946012769 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 909946012770 ATP binding site [chemical binding]; other site 909946012771 substrate interface [chemical binding]; other site 909946012772 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 909946012773 thiamine phosphate binding site [chemical binding]; other site 909946012774 active site 909946012775 pyrophosphate binding site [ion binding]; other site 909946012776 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 909946012777 ThiC-associated domain; Region: ThiC-associated; pfam13667 909946012778 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 909946012779 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 909946012780 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 909946012781 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 909946012782 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 909946012783 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 909946012784 putative NADH binding site [chemical binding]; other site 909946012785 putative active site [active] 909946012786 nudix motif; other site 909946012787 putative metal binding site [ion binding]; other site 909946012788 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 909946012789 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 909946012790 substrate binding site [chemical binding]; other site 909946012791 active site 909946012792 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 909946012793 Active_site [active] 909946012794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 909946012795 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 909946012796 IHF dimer interface [polypeptide binding]; other site 909946012797 IHF - DNA interface [nucleotide binding]; other site 909946012798 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 909946012799 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 909946012800 dimer interface [polypeptide binding]; other site 909946012801 sensor protein ZraS; Provisional; Region: PRK10364 909946012802 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946012803 dimer interface [polypeptide binding]; other site 909946012804 phosphorylation site [posttranslational modification] 909946012805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946012806 ATP binding site [chemical binding]; other site 909946012807 Mg2+ binding site [ion binding]; other site 909946012808 G-X-G motif; other site 909946012809 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 909946012810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946012811 active site 909946012812 phosphorylation site [posttranslational modification] 909946012813 intermolecular recognition site; other site 909946012814 dimerization interface [polypeptide binding]; other site 909946012815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946012816 Walker A motif; other site 909946012817 ATP binding site [chemical binding]; other site 909946012818 Walker B motif; other site 909946012819 arginine finger; other site 909946012820 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 909946012821 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 909946012822 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 909946012823 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 909946012824 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 909946012825 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 909946012826 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 909946012827 purine monophosphate binding site [chemical binding]; other site 909946012828 dimer interface [polypeptide binding]; other site 909946012829 putative catalytic residues [active] 909946012830 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 909946012831 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 909946012832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946012833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 909946012834 Coenzyme A binding pocket [chemical binding]; other site 909946012835 homoserine O-succinyltransferase; Provisional; Region: PRK05368 909946012836 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 909946012837 proposed active site lysine [active] 909946012838 conserved cys residue [active] 909946012839 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 909946012840 malate synthase A; Region: malate_syn_A; TIGR01344 909946012841 active site 909946012842 isocitrate lyase; Provisional; Region: PRK15063 909946012843 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 909946012844 tetramer interface [polypeptide binding]; other site 909946012845 active site 909946012846 Mg2+/Mn2+ binding site [ion binding]; other site 909946012847 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 909946012848 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 909946012849 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 909946012850 transcriptional repressor IclR; Provisional; Region: PRK11569 909946012851 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 909946012852 Bacterial transcriptional regulator; Region: IclR; pfam01614 909946012853 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 909946012854 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 909946012855 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 909946012856 substrate binding pocket [chemical binding]; other site 909946012857 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 909946012858 B12 binding site [chemical binding]; other site 909946012859 cobalt ligand [ion binding]; other site 909946012860 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 909946012861 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 909946012862 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 909946012863 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 909946012864 active site pocket [active] 909946012865 oxyanion hole [active] 909946012866 catalytic triad [active] 909946012867 active site nucleophile [active] 909946012868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 909946012869 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 909946012870 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909946012871 RNA binding surface [nucleotide binding]; other site 909946012872 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 909946012873 probable active site [active] 909946012874 hypothetical protein; Provisional; Region: PRK10515 909946012875 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 909946012876 Sodium Bile acid symporter family; Region: SBF; pfam01758 909946012877 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 909946012878 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 909946012879 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 909946012880 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 909946012881 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 909946012882 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 909946012883 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 909946012884 Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948 909946012885 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 909946012886 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 909946012887 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 909946012888 Ligand binding site; other site 909946012889 Putative Catalytic site; other site 909946012890 DXD motif; other site 909946012891 Predicted membrane protein [Function unknown]; Region: COG2246 909946012892 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 909946012893 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 909946012894 Phage protein D [General function prediction only]; Region: COG3500 909946012895 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 909946012896 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 909946012897 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 909946012898 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 909946012899 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 909946012900 Phage tail tube protein FII [General function prediction only]; Region: COG3498 909946012901 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 909946012902 Gp37 protein; Region: Gp37; pfam09646 909946012903 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 909946012904 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 909946012905 N-acetyl-D-glucosamine binding site [chemical binding]; other site 909946012906 catalytic residue [active] 909946012907 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 909946012908 Mor transcription activator family; Region: Mor; pfam08765 909946012909 aspartate kinase III; Validated; Region: PRK09084 909946012910 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 909946012911 nucleotide binding site [chemical binding]; other site 909946012912 substrate binding site [chemical binding]; other site 909946012913 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 909946012914 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 909946012915 dimer interface [polypeptide binding]; other site 909946012916 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 909946012917 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 909946012918 active site 909946012919 dimer interface [polypeptide binding]; other site 909946012920 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 909946012921 dimer interface [polypeptide binding]; other site 909946012922 active site 909946012923 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 909946012924 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 909946012925 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 909946012926 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 909946012927 Predicted membrane protein [Function unknown]; Region: COG3223 909946012928 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 909946012929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946012930 dimer interface [polypeptide binding]; other site 909946012931 conserved gate region; other site 909946012932 putative PBP binding loops; other site 909946012933 ABC-ATPase subunit interface; other site 909946012934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909946012935 dimer interface [polypeptide binding]; other site 909946012936 conserved gate region; other site 909946012937 putative PBP binding loops; other site 909946012938 ABC-ATPase subunit interface; other site 909946012939 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 909946012940 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 909946012941 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 909946012942 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 909946012943 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 909946012944 Walker A/P-loop; other site 909946012945 ATP binding site [chemical binding]; other site 909946012946 Q-loop/lid; other site 909946012947 ABC transporter signature motif; other site 909946012948 Walker B; other site 909946012949 D-loop; other site 909946012950 H-loop/switch region; other site 909946012951 TOBE domain; Region: TOBE_2; pfam08402 909946012952 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 909946012953 trimer interface; other site 909946012954 sugar binding site [chemical binding]; other site 909946012955 maltose regulon periplasmic protein; Provisional; Region: PRK10564 909946012956 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 909946012957 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 909946012958 UbiA prenyltransferase family; Region: UbiA; pfam01040 909946012959 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 909946012960 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 909946012961 putative acyl-acceptor binding pocket; other site 909946012962 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 909946012963 LexA repressor; Validated; Region: PRK00215 909946012964 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 909946012965 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 909946012966 Catalytic site [active] 909946012967 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 909946012968 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 909946012969 hypothetical protein; Provisional; Region: PRK10428 909946012970 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 909946012971 metal binding site 2 [ion binding]; metal-binding site 909946012972 putative DNA binding helix; other site 909946012973 metal binding site 1 [ion binding]; metal-binding site 909946012974 dimer interface [polypeptide binding]; other site 909946012975 structural Zn2+ binding site [ion binding]; other site 909946012976 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 909946012977 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 909946012978 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 909946012979 FMN binding site [chemical binding]; other site 909946012980 active site 909946012981 catalytic residues [active] 909946012982 substrate binding site [chemical binding]; other site 909946012983 phage shock protein G; Reviewed; Region: pspG; PRK09459 909946012984 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 909946012985 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 909946012986 NADP binding site [chemical binding]; other site 909946012987 dimer interface [polypeptide binding]; other site 909946012988 replicative DNA helicase; Provisional; Region: PRK08006 909946012989 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 909946012990 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 909946012991 Walker A motif; other site 909946012992 ATP binding site [chemical binding]; other site 909946012993 Walker B motif; other site 909946012994 DNA binding loops [nucleotide binding] 909946012995 alanine racemase; Reviewed; Region: alr; PRK00053 909946012996 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 909946012997 active site 909946012998 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 909946012999 substrate binding site [chemical binding]; other site 909946013000 catalytic residues [active] 909946013001 dimer interface [polypeptide binding]; other site 909946013002 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 909946013003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909946013004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946013005 homodimer interface [polypeptide binding]; other site 909946013006 catalytic residue [active] 909946013007 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 909946013008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946013009 active site 909946013010 motif I; other site 909946013011 motif II; other site 909946013012 Uncharacterized conserved protein [Function unknown]; Region: COG0432 909946013013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 909946013014 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 909946013015 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 909946013016 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 909946013017 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 909946013018 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 909946013019 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 909946013020 dimer interface [polypeptide binding]; other site 909946013021 ssDNA binding site [nucleotide binding]; other site 909946013022 tetramer (dimer of dimers) interface [polypeptide binding]; other site 909946013023 hypothetical protein; Validated; Region: PRK09039 909946013024 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 909946013025 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 909946013026 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 909946013027 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 909946013028 HlyD family secretion protein; Region: HlyD_3; pfam13437 909946013029 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 909946013030 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013031 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013032 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013033 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013034 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013035 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 909946013036 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 909946013037 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013038 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 909946013039 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 909946013040 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013041 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 909946013042 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013043 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 909946013044 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 909946013045 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013046 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 909946013047 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013048 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 909946013049 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 909946013050 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013051 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 909946013052 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 909946013053 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013054 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 909946013055 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013056 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013057 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 909946013058 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013059 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013060 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013061 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013062 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013063 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 909946013064 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013065 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 909946013066 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013067 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 909946013068 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013069 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 909946013070 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 909946013071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946013072 Walker A/P-loop; other site 909946013073 ATP binding site [chemical binding]; other site 909946013074 Q-loop/lid; other site 909946013075 ABC transporter signature motif; other site 909946013076 Walker B; other site 909946013077 D-loop; other site 909946013078 H-loop/switch region; other site 909946013079 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 909946013080 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 909946013081 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946013082 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 909946013083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946013084 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 909946013085 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 909946013086 DNA binding residues [nucleotide binding] 909946013087 dimer interface [polypeptide binding]; other site 909946013088 [2Fe-2S] cluster binding site [ion binding]; other site 909946013089 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 909946013090 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 909946013091 putative C-terminal domain interface [polypeptide binding]; other site 909946013092 putative GSH binding site (G-site) [chemical binding]; other site 909946013093 putative dimer interface [polypeptide binding]; other site 909946013094 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 909946013095 putative N-terminal domain interface [polypeptide binding]; other site 909946013096 putative dimer interface [polypeptide binding]; other site 909946013097 putative substrate binding pocket (H-site) [chemical binding]; other site 909946013098 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 909946013099 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 909946013100 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 909946013101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909946013102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946013103 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 909946013104 putative dimerization interface [polypeptide binding]; other site 909946013105 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 909946013106 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 909946013107 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 909946013108 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 909946013109 Na binding site [ion binding]; other site 909946013110 Predicted membrane protein [Function unknown]; Region: COG3162 909946013111 acetyl-CoA synthetase; Provisional; Region: PRK00174 909946013112 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 909946013113 active site 909946013114 CoA binding site [chemical binding]; other site 909946013115 acyl-activating enzyme (AAE) consensus motif; other site 909946013116 AMP binding site [chemical binding]; other site 909946013117 acetate binding site [chemical binding]; other site 909946013118 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 909946013119 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 909946013120 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 909946013121 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 909946013122 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 909946013123 heme lyase subunit NrfE; Provisional; Region: PRK10369 909946013124 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 909946013125 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 909946013126 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 909946013127 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 909946013128 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 909946013129 Sel1-like repeats; Region: SEL1; smart00671 909946013130 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 909946013131 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 909946013132 [4Fe-4S] binding site [ion binding]; other site 909946013133 molybdopterin cofactor binding site; other site 909946013134 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 909946013135 molybdopterin cofactor binding site; other site 909946013136 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 909946013137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946013138 Coenzyme A binding pocket [chemical binding]; other site 909946013139 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 909946013140 dimer interface [polypeptide binding]; other site 909946013141 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 909946013142 hypothetical protein; Provisional; Region: PRK10220 909946013143 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 909946013144 PhnA protein; Region: PhnA; pfam03831 909946013145 proline/glycine betaine transporter; Provisional; Region: PRK10642 909946013146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946013147 putative substrate translocation pore; other site 909946013148 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 909946013149 sensor protein BasS/PmrB; Provisional; Region: PRK10755 909946013150 HAMP domain; Region: HAMP; pfam00672 909946013151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946013152 dimer interface [polypeptide binding]; other site 909946013153 phosphorylation site [posttranslational modification] 909946013154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946013155 ATP binding site [chemical binding]; other site 909946013156 Mg2+ binding site [ion binding]; other site 909946013157 G-X-G motif; other site 909946013158 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 909946013159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946013160 active site 909946013161 phosphorylation site [posttranslational modification] 909946013162 intermolecular recognition site; other site 909946013163 dimerization interface [polypeptide binding]; other site 909946013164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946013165 DNA binding site [nucleotide binding] 909946013166 putative metal dependent hydrolase; Provisional; Region: PRK11598 909946013167 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 909946013168 Sulfatase; Region: Sulfatase; pfam00884 909946013169 arginine:agmatin antiporter; Provisional; Region: PRK10644 909946013170 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 909946013171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946013172 arginine decarboxylase; Provisional; Region: PRK15029 909946013173 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 909946013174 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 909946013175 homodimer interface [polypeptide binding]; other site 909946013176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909946013177 catalytic residue [active] 909946013178 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 909946013179 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 909946013180 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946013181 alpha-galactosidase; Provisional; Region: PRK15076 909946013182 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 909946013183 NAD binding site [chemical binding]; other site 909946013184 sugar binding site [chemical binding]; other site 909946013185 divalent metal binding site [ion binding]; other site 909946013186 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 909946013187 dimer interface [polypeptide binding]; other site 909946013188 melibiose:sodium symporter; Provisional; Region: PRK10429 909946013189 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 909946013190 fumarate hydratase; Provisional; Region: PRK15389 909946013191 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 909946013192 Fumarase C-terminus; Region: Fumerase_C; pfam05683 909946013193 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 909946013194 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 909946013195 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 909946013196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946013197 active site 909946013198 phosphorylation site [posttranslational modification] 909946013199 intermolecular recognition site; other site 909946013200 dimerization interface [polypeptide binding]; other site 909946013201 sensory histidine kinase DcuS; Provisional; Region: PRK11086 909946013202 PAS domain; Region: PAS; smart00091 909946013203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946013204 ATP binding site [chemical binding]; other site 909946013205 Mg2+ binding site [ion binding]; other site 909946013206 G-X-G motif; other site 909946013207 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 909946013208 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 909946013209 putative [Fe4-S4] binding site [ion binding]; other site 909946013210 putative molybdopterin cofactor binding site [chemical binding]; other site 909946013211 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 909946013212 putative molybdopterin cofactor binding site; other site 909946013213 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 909946013214 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 909946013215 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 909946013216 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 909946013217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 909946013218 SdiA-regulated; Region: SdiA-regulated; cd09971 909946013219 putative active site [active] 909946013220 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 909946013221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946013222 DNA binding residues [nucleotide binding] 909946013223 dimerization interface [polypeptide binding]; other site 909946013224 AraC family transcriptional regulator; Provisional; Region: PRK15186 909946013225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946013226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 909946013227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946013228 Coenzyme A binding pocket [chemical binding]; other site 909946013229 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 909946013230 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 909946013231 active site 909946013232 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 909946013233 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 909946013234 DNA binding residues [nucleotide binding] 909946013235 putative dimer interface [polypeptide binding]; other site 909946013236 putative transcriptional regulator; Provisional; Region: PRK11640 909946013237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909946013238 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 909946013239 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 909946013240 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 909946013241 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 909946013242 DsbD alpha interface [polypeptide binding]; other site 909946013243 catalytic residues [active] 909946013244 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 909946013245 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 909946013246 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 909946013247 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 909946013248 Aspartase; Region: Aspartase; cd01357 909946013249 active sites [active] 909946013250 tetramer interface [polypeptide binding]; other site 909946013251 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 909946013252 putative transporter; Provisional; Region: PRK11021 909946013253 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 909946013254 oligomerisation interface [polypeptide binding]; other site 909946013255 mobile loop; other site 909946013256 roof hairpin; other site 909946013257 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 909946013258 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 909946013259 ring oligomerisation interface [polypeptide binding]; other site 909946013260 ATP/Mg binding site [chemical binding]; other site 909946013261 stacking interactions; other site 909946013262 hinge regions; other site 909946013263 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 909946013264 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 909946013265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946013266 FeS/SAM binding site; other site 909946013267 elongation factor P; Validated; Region: PRK00529 909946013268 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 909946013269 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 909946013270 RNA binding site [nucleotide binding]; other site 909946013271 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 909946013272 RNA binding site [nucleotide binding]; other site 909946013273 Predicted small secreted protein [Function unknown]; Region: COG5510 909946013274 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 909946013275 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 909946013276 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946013277 DNA binding residues [nucleotide binding] 909946013278 dimerization interface [polypeptide binding]; other site 909946013279 multidrug efflux system protein; Provisional; Region: PRK11431 909946013280 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 909946013281 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 909946013282 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 909946013283 Iron-sulfur protein interface; other site 909946013284 proximal quinone binding site [chemical binding]; other site 909946013285 C-subunit interface; other site 909946013286 distal quinone binding site; other site 909946013287 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 909946013288 D-subunit interface [polypeptide binding]; other site 909946013289 Iron-sulfur protein interface; other site 909946013290 proximal quinone binding site [chemical binding]; other site 909946013291 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 909946013292 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 909946013293 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 909946013294 L-aspartate oxidase; Provisional; Region: PRK06175 909946013295 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 909946013296 poxB regulator PoxA; Provisional; Region: PRK09350 909946013297 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 909946013298 motif 1; other site 909946013299 dimer interface [polypeptide binding]; other site 909946013300 active site 909946013301 motif 2; other site 909946013302 motif 3; other site 909946013303 inner membrane transporter YjeM; Provisional; Region: PRK15238 909946013304 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 909946013305 putative mechanosensitive channel protein; Provisional; Region: PRK10929 909946013306 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 909946013307 Mechanosensitive ion channel; Region: MS_channel; pfam00924 909946013308 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 909946013309 GTPase RsgA; Reviewed; Region: PRK12288 909946013310 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 909946013311 RNA binding site [nucleotide binding]; other site 909946013312 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 909946013313 GTPase/Zn-binding domain interface [polypeptide binding]; other site 909946013314 GTP/Mg2+ binding site [chemical binding]; other site 909946013315 G4 box; other site 909946013316 G5 box; other site 909946013317 G1 box; other site 909946013318 Switch I region; other site 909946013319 G2 box; other site 909946013320 G3 box; other site 909946013321 Switch II region; other site 909946013322 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 909946013323 catalytic site [active] 909946013324 putative active site [active] 909946013325 putative substrate binding site [chemical binding]; other site 909946013326 dimer interface [polypeptide binding]; other site 909946013327 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 909946013328 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 909946013329 substrate binding pocket [chemical binding]; other site 909946013330 membrane-bound complex binding site; other site 909946013331 hinge residues; other site 909946013332 epoxyqueuosine reductase; Region: TIGR00276 909946013333 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 909946013334 putative carbohydrate kinase; Provisional; Region: PRK10565 909946013335 Uncharacterized conserved protein [Function unknown]; Region: COG0062 909946013336 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 909946013337 putative substrate binding site [chemical binding]; other site 909946013338 putative ATP binding site [chemical binding]; other site 909946013339 ADP-binding protein; Provisional; Region: PRK10646 909946013340 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 909946013341 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 909946013342 active site 909946013343 metal binding site [ion binding]; metal-binding site 909946013344 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 909946013345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946013346 ATP binding site [chemical binding]; other site 909946013347 Mg2+ binding site [ion binding]; other site 909946013348 G-X-G motif; other site 909946013349 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 909946013350 ATP binding site [chemical binding]; other site 909946013351 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 909946013352 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 909946013353 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 909946013354 bacterial Hfq-like; Region: Hfq; cd01716 909946013355 hexamer interface [polypeptide binding]; other site 909946013356 Sm1 motif; other site 909946013357 RNA binding site [nucleotide binding]; other site 909946013358 Sm2 motif; other site 909946013359 GTPase HflX; Provisional; Region: PRK11058 909946013360 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 909946013361 HflX GTPase family; Region: HflX; cd01878 909946013362 G1 box; other site 909946013363 GTP/Mg2+ binding site [chemical binding]; other site 909946013364 Switch I region; other site 909946013365 G2 box; other site 909946013366 G3 box; other site 909946013367 Switch II region; other site 909946013368 G4 box; other site 909946013369 G5 box; other site 909946013370 FtsH protease regulator HflK; Provisional; Region: PRK10930 909946013371 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 909946013372 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 909946013373 FtsH protease regulator HflC; Provisional; Region: PRK11029 909946013374 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 909946013375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 909946013376 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 909946013377 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 909946013378 GDP-binding site [chemical binding]; other site 909946013379 ACT binding site; other site 909946013380 IMP binding site; other site 909946013381 transcriptional repressor NsrR; Provisional; Region: PRK11014 909946013382 Predicted transcriptional regulator [Transcription]; Region: COG1959 909946013383 exoribonuclease R; Provisional; Region: PRK11642 909946013384 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 909946013385 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 909946013386 RNB domain; Region: RNB; pfam00773 909946013387 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 909946013388 RNA binding site [nucleotide binding]; other site 909946013389 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 909946013390 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 909946013391 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 909946013392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 909946013393 Ion channel; Region: Ion_trans_2; pfam07885 909946013394 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 909946013395 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 909946013396 Predicted membrane protein [Function unknown]; Region: COG3766 909946013397 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 909946013398 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 909946013399 Predicted integral membrane protein [Function unknown]; Region: COG5463 909946013400 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 909946013401 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 909946013402 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 909946013403 FAD binding site [chemical binding]; other site 909946013404 substrate binding site [chemical binding]; other site 909946013405 catalytic residues [active] 909946013406 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 909946013407 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 909946013408 esterase; Provisional; Region: PRK10566 909946013409 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 909946013410 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 909946013411 transcriptional repressor UlaR; Provisional; Region: PRK13509 909946013412 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 909946013413 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909946013414 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 909946013415 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 909946013416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 909946013417 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 909946013418 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 909946013419 active site 909946013420 P-loop; other site 909946013421 phosphorylation site [posttranslational modification] 909946013422 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909946013423 active site 909946013424 phosphorylation site [posttranslational modification] 909946013425 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 909946013426 active site 909946013427 dimer interface [polypeptide binding]; other site 909946013428 magnesium binding site [ion binding]; other site 909946013429 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 909946013430 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 909946013431 AP (apurinic/apyrimidinic) site pocket; other site 909946013432 DNA interaction; other site 909946013433 Metal-binding active site; metal-binding site 909946013434 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 909946013435 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 909946013436 intersubunit interface [polypeptide binding]; other site 909946013437 active site 909946013438 Zn2+ binding site [ion binding]; other site 909946013439 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 909946013440 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 909946013441 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 909946013442 dimer interface [polypeptide binding]; other site 909946013443 ssDNA binding site [nucleotide binding]; other site 909946013444 tetramer (dimer of dimers) interface [polypeptide binding]; other site 909946013445 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 909946013446 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 909946013447 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 909946013448 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 909946013449 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 909946013450 EamA-like transporter family; Region: EamA; pfam00892 909946013451 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 909946013452 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 909946013453 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 909946013454 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 909946013455 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 909946013456 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 909946013457 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 909946013458 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 909946013459 Hemerythrin-like domain; Region: Hr-like; cd12108 909946013460 Fe binding site [ion binding]; other site 909946013461 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 909946013462 EamA-like transporter family; Region: EamA; pfam00892 909946013463 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 909946013464 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 909946013465 NADP binding site [chemical binding]; other site 909946013466 Predicted transcriptional regulators [Transcription]; Region: COG1733 909946013467 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 909946013468 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 909946013469 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 909946013470 active site 909946013471 metal binding site [ion binding]; metal-binding site 909946013472 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 909946013473 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 909946013474 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 909946013475 active site 909946013476 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 909946013477 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 909946013478 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 909946013479 Domain of unknown function DUF21; Region: DUF21; pfam01595 909946013480 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 909946013481 Transporter associated domain; Region: CorC_HlyC; smart01091 909946013482 methionine sulfoxide reductase A; Provisional; Region: PRK00058 909946013483 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 909946013484 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 909946013485 Surface antigen; Region: Bac_surface_Ag; pfam01103 909946013486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 909946013487 Family of unknown function (DUF490); Region: DUF490; pfam04357 909946013488 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 909946013489 putative active site pocket [active] 909946013490 dimerization interface [polypeptide binding]; other site 909946013491 putative catalytic residue [active] 909946013492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946013493 D-galactonate transporter; Region: 2A0114; TIGR00893 909946013494 putative substrate translocation pore; other site 909946013495 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 909946013496 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 909946013497 active site 909946013498 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 909946013499 dimer interface [polypeptide binding]; other site 909946013500 substrate binding site [chemical binding]; other site 909946013501 metal binding sites [ion binding]; metal-binding site 909946013502 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 909946013503 AMP binding site [chemical binding]; other site 909946013504 metal binding site [ion binding]; metal-binding site 909946013505 active site 909946013506 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 909946013507 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 909946013508 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 909946013509 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 909946013510 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 909946013511 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 909946013512 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 909946013513 putative active site [active] 909946013514 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 909946013515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946013516 putative substrate translocation pore; other site 909946013517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946013518 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 909946013519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946013520 putative substrate translocation pore; other site 909946013521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946013522 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 909946013523 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 909946013524 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 909946013525 tetrameric interface [polypeptide binding]; other site 909946013526 NAD binding site [chemical binding]; other site 909946013527 catalytic residues [active] 909946013528 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 909946013529 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 909946013530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946013531 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 909946013532 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 909946013533 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909946013534 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909946013535 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 909946013536 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 909946013537 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 909946013538 major facilitator superfamily transporter; Provisional; Region: PRK05122 909946013539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946013540 putative substrate translocation pore; other site 909946013541 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909946013542 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 909946013543 substrate binding site [chemical binding]; other site 909946013544 ATP binding site [chemical binding]; other site 909946013545 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 909946013546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 909946013547 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 909946013548 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 909946013549 PYR/PP interface [polypeptide binding]; other site 909946013550 dimer interface [polypeptide binding]; other site 909946013551 TPP binding site [chemical binding]; other site 909946013552 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 909946013553 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 909946013554 TPP-binding site; other site 909946013555 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 909946013556 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909946013557 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909946013558 polyol permease family; Region: 2A0118; TIGR00897 909946013559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946013560 putative substrate translocation pore; other site 909946013561 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 909946013562 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 909946013563 DNA interaction; other site 909946013564 Metal-binding active site; metal-binding site 909946013565 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 909946013566 hypothetical protein; Provisional; Region: PRK05255 909946013567 peptidase PmbA; Provisional; Region: PRK11040 909946013568 cytochrome b562; Provisional; Region: PRK15058 909946013569 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 909946013570 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 909946013571 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 909946013572 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 909946013573 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 909946013574 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 909946013575 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 909946013576 active site 909946013577 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 909946013578 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 909946013579 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 909946013580 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 909946013581 HTH domain; Region: HTH_11; pfam08279 909946013582 Mga helix-turn-helix domain; Region: Mga; pfam05043 909946013583 PRD domain; Region: PRD; pfam00874 909946013584 PRD domain; Region: PRD; pfam00874 909946013585 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 909946013586 active site 909946013587 P-loop; other site 909946013588 phosphorylation site [posttranslational modification] 909946013589 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909946013590 active site 909946013591 phosphorylation site [posttranslational modification] 909946013592 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 909946013593 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 909946013594 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 909946013595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946013596 FeS/SAM binding site; other site 909946013597 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 909946013598 ATP cone domain; Region: ATP-cone; pfam03477 909946013599 Class III ribonucleotide reductase; Region: RNR_III; cd01675 909946013600 effector binding site; other site 909946013601 active site 909946013602 Zn binding site [ion binding]; other site 909946013603 glycine loop; other site 909946013604 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 909946013605 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 909946013606 Ca binding site [ion binding]; other site 909946013607 active site 909946013608 catalytic site [active] 909946013609 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 909946013610 trehalose repressor; Provisional; Region: treR; PRK09492 909946013611 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946013612 DNA binding site [nucleotide binding] 909946013613 domain linker motif; other site 909946013614 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 909946013615 dimerization interface [polypeptide binding]; other site 909946013616 ligand binding site [chemical binding]; other site 909946013617 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 909946013618 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 909946013619 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 909946013620 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 909946013621 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 909946013622 Soluble P-type ATPase [General function prediction only]; Region: COG4087 909946013623 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 909946013624 Transposase; Region: HTH_Tnp_1; cl17663 909946013625 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 909946013626 homotrimer interaction site [polypeptide binding]; other site 909946013627 putative active site [active] 909946013628 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 909946013629 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 909946013630 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 909946013631 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 909946013632 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 909946013633 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 909946013634 pyrBI operon leader peptide; Provisional; Region: PRK10224 909946013635 Arginine repressor [Transcription]; Region: ArgR; COG1438 909946013636 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 909946013637 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 909946013638 Predicted membrane protein [Function unknown]; Region: COG1288 909946013639 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 909946013640 ornithine carbamoyltransferase; Validated; Region: PRK02102 909946013641 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 909946013642 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 909946013643 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 909946013644 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 909946013645 putative substrate binding site [chemical binding]; other site 909946013646 nucleotide binding site [chemical binding]; other site 909946013647 nucleotide binding site [chemical binding]; other site 909946013648 homodimer interface [polypeptide binding]; other site 909946013649 arginine deiminase; Provisional; Region: PRK01388 909946013650 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 909946013651 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 909946013652 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 909946013653 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 909946013654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 909946013655 RNase E inhibitor protein; Provisional; Region: PRK11191 909946013656 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 909946013657 active site 909946013658 dinuclear metal binding site [ion binding]; other site 909946013659 dimerization interface [polypeptide binding]; other site 909946013660 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 909946013661 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 909946013662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946013663 Coenzyme A binding pocket [chemical binding]; other site 909946013664 Predicted membrane protein [Function unknown]; Region: COG4269 909946013665 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 909946013666 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 909946013667 HIGH motif; other site 909946013668 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 909946013669 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 909946013670 active site 909946013671 KMSKS motif; other site 909946013672 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 909946013673 tRNA binding surface [nucleotide binding]; other site 909946013674 anticodon binding site; other site 909946013675 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 909946013676 DNA polymerase III subunit chi; Validated; Region: PRK05728 909946013677 multifunctional aminopeptidase A; Provisional; Region: PRK00913 909946013678 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 909946013679 interface (dimer of trimers) [polypeptide binding]; other site 909946013680 Substrate-binding/catalytic site; other site 909946013681 Zn-binding sites [ion binding]; other site 909946013682 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 909946013683 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 909946013684 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 909946013685 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 909946013686 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 909946013687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909946013688 DNA binding site [nucleotide binding] 909946013689 domain linker motif; other site 909946013690 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 909946013691 putative dimerization interface [polypeptide binding]; other site 909946013692 putative ligand binding site [chemical binding]; other site 909946013693 gluconate transporter; Region: gntP; TIGR00791 909946013694 fructuronate transporter; Provisional; Region: PRK10034; cl15264 909946013695 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 909946013696 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 909946013697 NADP binding site [chemical binding]; other site 909946013698 homodimer interface [polypeptide binding]; other site 909946013699 active site 909946013700 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 909946013701 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 909946013702 putative NAD(P) binding site [chemical binding]; other site 909946013703 catalytic Zn binding site [ion binding]; other site 909946013704 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 909946013705 ATP-binding site [chemical binding]; other site 909946013706 Gluconate-6-phosphate binding site [chemical binding]; other site 909946013707 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 909946013708 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 909946013709 putative NAD(P) binding site [chemical binding]; other site 909946013710 putative substrate binding site [chemical binding]; other site 909946013711 catalytic Zn binding site [ion binding]; other site 909946013712 structural Zn binding site [ion binding]; other site 909946013713 dimer interface [polypeptide binding]; other site 909946013714 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 909946013715 Part of AAA domain; Region: AAA_19; pfam13245 909946013716 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 909946013717 AAA domain; Region: AAA_12; pfam13087 909946013718 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 909946013719 putative active site [active] 909946013720 catalytic site [active] 909946013721 Uncharacterized conserved protein [Function unknown]; Region: COG4127 909946013722 Restriction endonuclease; Region: Mrr_cat; pfam04471 909946013723 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 909946013724 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 909946013725 TIGR02687 family protein; Region: TIGR02687 909946013726 PglZ domain; Region: PglZ; pfam08665 909946013727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946013728 AAA domain; Region: AAA_21; pfam13304 909946013729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946013730 Walker A/P-loop; other site 909946013731 Walker A/P-loop; other site 909946013732 ATP binding site [chemical binding]; other site 909946013733 ATP binding site [chemical binding]; other site 909946013734 Q-loop/lid; other site 909946013735 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 909946013736 Methyltransferase domain; Region: Methyltransf_26; pfam13659 909946013737 TIGR02680 family protein; Region: TIGR02680 909946013738 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 909946013739 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 909946013740 hypothetical protein; Provisional; Region: PRK12378 909946013741 Methyltransferase domain; Region: Methyltransf_23; pfam13489 909946013742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946013743 S-adenosylmethionine binding site [chemical binding]; other site 909946013744 Methyltransferase domain; Region: Methyltransf_31; pfam13847 909946013745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946013746 S-adenosylmethionine binding site [chemical binding]; other site 909946013747 hypothetical protein; Provisional; Region: PRK13687 909946013748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332 909946013749 Protein of unknown function DUF91; Region: DUF91; cl00709 909946013750 Uncharacterized conserved protein [Function unknown]; Region: COG3439 909946013751 Dienelactone hydrolase family; Region: DLH; pfam01738 909946013752 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 909946013753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909946013754 DNA-binding site [nucleotide binding]; DNA binding site 909946013755 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 909946013756 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 909946013757 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 909946013758 active site 909946013759 HIGH motif; other site 909946013760 dimer interface [polypeptide binding]; other site 909946013761 KMSKS motif; other site 909946013762 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 909946013763 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 909946013764 aspartate racemase; Region: asp_race; TIGR00035 909946013765 cell density-dependent motility repressor; Provisional; Region: PRK10082 909946013766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946013767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 909946013768 dimerization interface [polypeptide binding]; other site 909946013769 isoaspartyl dipeptidase; Provisional; Region: PRK10657 909946013770 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 909946013771 active site 909946013772 hypothetical protein; Provisional; Region: PRK10519 909946013773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 909946013774 Nucleoside recognition; Region: Gate; pfam07670 909946013775 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 909946013776 Predicted membrane protein [Function unknown]; Region: COG2733 909946013777 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 909946013778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909946013779 putative substrate translocation pore; other site 909946013780 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 909946013781 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 909946013782 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 909946013783 NAD(P) binding site [chemical binding]; other site 909946013784 catalytic residues [active] 909946013785 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 909946013786 endoribonuclease SymE; Provisional; Region: PRK13605 909946013787 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 909946013788 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 909946013789 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 909946013790 HsdM N-terminal domain; Region: HsdM_N; pfam12161 909946013791 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 909946013792 Methyltransferase domain; Region: Methyltransf_26; pfam13659 909946013793 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 909946013794 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 909946013795 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 909946013796 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909946013797 ATP binding site [chemical binding]; other site 909946013798 putative Mg++ binding site [ion binding]; other site 909946013799 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 909946013800 Mrr N-terminal domain; Region: Mrr_N; pfam14338 909946013801 Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030 909946013802 Restriction endonuclease; Region: Mrr_cat; pfam04471 909946013803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 909946013804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 909946013805 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 909946013806 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 909946013807 P-loop, Walker A motif; other site 909946013808 Base recognition motif; other site 909946013809 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 909946013810 Uncharacterized small protein [Function unknown]; Region: COG2879 909946013811 carbon starvation protein A; Provisional; Region: PRK15015 909946013812 Carbon starvation protein CstA; Region: CstA; pfam02554 909946013813 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 909946013814 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 909946013815 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 909946013816 dimer interface [polypeptide binding]; other site 909946013817 ligand binding site [chemical binding]; other site 909946013818 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909946013819 dimerization interface [polypeptide binding]; other site 909946013820 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 909946013821 dimer interface [polypeptide binding]; other site 909946013822 putative CheW interface [polypeptide binding]; other site 909946013823 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 909946013824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946013825 Walker A motif; other site 909946013826 ATP binding site [chemical binding]; other site 909946013827 Walker B motif; other site 909946013828 arginine finger; other site 909946013829 Transcriptional antiterminator [Transcription]; Region: COG3933 909946013830 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 909946013831 active pocket/dimerization site; other site 909946013832 active site 909946013833 phosphorylation site [posttranslational modification] 909946013834 PRD domain; Region: PRD; pfam00874 909946013835 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 909946013836 active pocket/dimerization site; other site 909946013837 active site 909946013838 phosphorylation site [posttranslational modification] 909946013839 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 909946013840 active site 909946013841 phosphorylation site [posttranslational modification] 909946013842 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 909946013843 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 909946013844 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 909946013845 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 909946013846 dimer interface [polypeptide binding]; other site 909946013847 active site 909946013848 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 909946013849 dimer interface [polypeptide binding]; other site 909946013850 active site 909946013851 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 909946013852 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 909946013853 putative active site [active] 909946013854 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 909946013855 phosphoglycerol transferase I; Provisional; Region: PRK03776 909946013856 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 909946013857 hypothetical protein; Provisional; Region: PRK11667 909946013858 DNA replication protein DnaC; Validated; Region: PRK07952 909946013859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909946013860 Walker A motif; other site 909946013861 ATP binding site [chemical binding]; other site 909946013862 Walker B motif; other site 909946013863 primosomal protein DnaI; Provisional; Region: PRK02854 909946013864 hypothetical protein; Provisional; Region: PRK09917 909946013865 Uncharacterized conserved protein [Function unknown]; Region: COG2966 909946013866 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 909946013867 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 909946013868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946013869 DNA binding residues [nucleotide binding] 909946013870 dimerization interface [polypeptide binding]; other site 909946013871 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 909946013872 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946013873 DNA binding residues [nucleotide binding] 909946013874 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 909946013875 putative deacylase active site [active] 909946013876 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 909946013877 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 909946013878 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 909946013879 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 909946013880 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 909946013881 metal binding site [ion binding]; metal-binding site 909946013882 active site 909946013883 I-site; other site 909946013884 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 909946013885 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 909946013886 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 909946013887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909946013888 S-adenosylmethionine binding site [chemical binding]; other site 909946013889 DNA polymerase III subunit psi; Validated; Region: PRK06856 909946013890 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 909946013891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909946013892 Coenzyme A binding pocket [chemical binding]; other site 909946013893 dUMP phosphatase; Provisional; Region: PRK09449 909946013894 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946013895 motif II; other site 909946013896 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 909946013897 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 909946013898 G1 box; other site 909946013899 putative GEF interaction site [polypeptide binding]; other site 909946013900 GTP/Mg2+ binding site [chemical binding]; other site 909946013901 Switch I region; other site 909946013902 G2 box; other site 909946013903 G3 box; other site 909946013904 Switch II region; other site 909946013905 G4 box; other site 909946013906 G5 box; other site 909946013907 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 909946013908 periplasmic protein; Provisional; Region: PRK10568 909946013909 BON domain; Region: BON; pfam04972 909946013910 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 909946013911 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 909946013912 active site 909946013913 nucleophile elbow; other site 909946013914 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 909946013915 active site 909946013916 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 909946013917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909946013918 FeS/SAM binding site; other site 909946013919 hypothetical protein; Provisional; Region: PRK10977 909946013920 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 909946013921 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 909946013922 intersubunit interface [polypeptide binding]; other site 909946013923 active site 909946013924 catalytic residue [active] 909946013925 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 909946013926 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 909946013927 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 909946013928 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 909946013929 phosphopentomutase; Provisional; Region: PRK05362 909946013930 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 909946013931 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 909946013932 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 909946013933 hypothetical protein; Provisional; Region: PRK15301 909946013934 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 909946013935 PapC N-terminal domain; Region: PapC_N; pfam13954 909946013936 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 909946013937 PapC C-terminal domain; Region: PapC_C; pfam13953 909946013938 putative fimbrial chaperone protein; Provisional; Region: PRK09918 909946013939 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946013940 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946013941 hypothetical protein; Provisional; Region: PRK15302 909946013942 hypothetical protein; Provisional; Region: PRK15303 909946013943 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 909946013944 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 909946013945 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 909946013946 hypothetical protein; Provisional; Region: PRK11246 909946013947 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 909946013948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909946013949 motif II; other site 909946013950 DNA repair protein RadA; Region: sms; TIGR00416 909946013951 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 909946013952 Walker A motif/ATP binding site; other site 909946013953 ATP binding site [chemical binding]; other site 909946013954 Walker B motif; other site 909946013955 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 909946013956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909946013957 non-specific DNA binding site [nucleotide binding]; other site 909946013958 salt bridge; other site 909946013959 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 909946013960 sequence-specific DNA binding site [nucleotide binding]; other site 909946013961 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 909946013962 active site 909946013963 (T/H)XGH motif; other site 909946013964 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 909946013965 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 909946013966 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909946013967 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909946013968 ABC transporter; Region: ABC_tran_2; pfam12848 909946013969 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909946013970 lytic murein transglycosylase; Provisional; Region: PRK11619 909946013971 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 909946013972 N-acetyl-D-glucosamine binding site [chemical binding]; other site 909946013973 catalytic residue [active] 909946013974 Trp operon repressor; Provisional; Region: PRK01381 909946013975 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 909946013976 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 909946013977 catalytic core [active] 909946013978 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 909946013979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946013980 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 909946013981 hypothetical protein; Provisional; Region: PRK10756 909946013982 CreA protein; Region: CreA; pfam05981 909946013983 DNA-binding response regulator CreB; Provisional; Region: PRK11083 909946013984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946013985 active site 909946013986 phosphorylation site [posttranslational modification] 909946013987 intermolecular recognition site; other site 909946013988 dimerization interface [polypeptide binding]; other site 909946013989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946013990 DNA binding site [nucleotide binding] 909946013991 sensory histidine kinase CreC; Provisional; Region: PRK11100 909946013992 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 909946013993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909946013994 dimer interface [polypeptide binding]; other site 909946013995 phosphorylation site [posttranslational modification] 909946013996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909946013997 ATP binding site [chemical binding]; other site 909946013998 Mg2+ binding site [ion binding]; other site 909946013999 G-X-G motif; other site 909946014000 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 909946014001 putative major fimbrial protein SthE; Provisional; Region: PRK15292 909946014002 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 909946014003 putative fimbrial protein SthD; Provisional; Region: PRK15293 909946014004 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 909946014005 PapC N-terminal domain; Region: PapC_N; pfam13954 909946014006 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 909946014007 PapC C-terminal domain; Region: PapC_C; pfam13953 909946014008 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 909946014009 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946014010 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946014011 putative fimbrial protein SthA; Provisional; Region: PRK15296 909946014012 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 909946014013 Helix-turn-helix domain; Region: HTH_36; pfam13730 909946014014 two-component response regulator; Provisional; Region: PRK11173 909946014015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909946014016 active site 909946014017 phosphorylation site [posttranslational modification] 909946014018 intermolecular recognition site; other site 909946014019 dimerization interface [polypeptide binding]; other site 909946014020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909946014021 DNA binding site [nucleotide binding] 909946014022 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 909946014023 putative RNA methyltransferase; Provisional; Region: PRK10433 909946014024 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 909946014025 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 909946014026 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 909946014027 putative kissing complex interaction region; other site 909946014028 putative RNA binding sites [nucleotide binding]; other site 909946014029 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 909946014030 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 909946014031 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 909946014032 AAA domain; Region: AAA_30; pfam13604 909946014033 DNA helicase TraI; Region: TraI; pfam07057 909946014034 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 909946014035 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 909946014036 oligomeric interface; other site 909946014037 putative active site [active] 909946014038 homodimer interface [polypeptide binding]; other site 909946014039 conjugal transfer protein TraD; Provisional; Region: PRK13700 909946014040 F sex factor protein N terminal; Region: TraD_N; pfam12615 909946014041 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 909946014042 multimer interface [polypeptide binding]; other site 909946014043 Walker A motif; other site 909946014044 ATP binding site [chemical binding]; other site 909946014045 Walker B motif; other site 909946014046 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 909946014047 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 909946014048 Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624 909946014049 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 909946014050 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 909946014051 conjugal transfer protein TrbB; Provisional; Region: PRK13728 909946014052 conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727 909946014053 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 909946014054 F plasmid transfer operon protein; Region: TraF; pfam13728 909946014055 conjugal transfer protein TrbE; Provisional; Region: PRK13718 909946014056 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 909946014057 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 909946014058 active site 909946014059 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 909946014060 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 909946014061 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 909946014062 conjugal transfer protein TrbI; Provisional; Region: PRK13717 909946014063 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 909946014064 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 909946014065 Domain of unknown function DUF87; Region: DUF87; pfam01935 909946014066 conjugal transfer protein TraR; Provisional; Region: PRK13715 909946014067 conjugal transfer protein TraV; Provisional; Region: PRK13733 909946014068 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 909946014069 conjugal transfer protein TrbD; Provisional; Region: PRK13724 909946014070 NTPase; Region: NTPase_1; cl17478 909946014071 TraP protein; Region: TraP; pfam07296 909946014072 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 909946014073 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 909946014074 conjugal transfer protein TraK; Provisional; Region: PRK13736 909946014075 TraK protein; Region: TraK; pfam06586 909946014076 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 909946014077 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 909946014078 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 909946014079 conjugal transfer protein TraY; Provisional; Region: PRK13740 909946014080 conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719 909946014081 conjugal transfer protein TraM; Provisional; Region: PRK13713 909946014082 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 909946014083 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 909946014084 N-acetyl-D-glucosamine binding site [chemical binding]; other site 909946014085 catalytic residue [active] 909946014086 PsiA protein; Region: PsiA; pfam06952 909946014087 Plasmid SOS inhibition protein (PsiB); Region: PsiB; pfam06290 909946014088 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 909946014089 ParB-like nuclease domain; Region: ParBc; pfam02195 909946014090 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 909946014091 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 909946014092 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 909946014093 dimer interface [polypeptide binding]; other site 909946014094 ssDNA binding site [nucleotide binding]; other site 909946014095 tetramer (dimer of dimers) interface [polypeptide binding]; other site 909946014096 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 909946014097 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 909946014098 Antirestriction protein; Region: Antirestrict; pfam03230 909946014099 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 909946014100 putative methylase; Provisional; Region: PRK13699 909946014101 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 909946014102 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 909946014103 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 909946014104 Catalytic site [active] 909946014105 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 909946014106 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 909946014107 active site 909946014108 DNA binding site [nucleotide binding] 909946014109 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 909946014110 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 909946014111 ParB-like nuclease domain; Region: ParBc; pfam02195 909946014112 ParB family; Region: ParB; pfam08775 909946014113 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 909946014114 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 909946014115 P-loop; other site 909946014116 Magnesium ion binding site [ion binding]; other site 909946014117 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 909946014118 Magnesium ion binding site [ion binding]; other site 909946014119 Uncharacterized conserved protein [Function unknown]; Region: COG5464 909946014120 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 909946014121 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 909946014122 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 909946014123 catalytic site [active] 909946014124 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 909946014125 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 909946014126 active site clefts [active] 909946014127 zinc binding site [ion binding]; other site 909946014128 dimer interface [polypeptide binding]; other site 909946014129 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 909946014130 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 909946014131 catalytic residues [active] 909946014132 catalytic nucleophile [active] 909946014133 Presynaptic Site I dimer interface [polypeptide binding]; other site 909946014134 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 909946014135 Synaptic Flat tetramer interface [polypeptide binding]; other site 909946014136 Synaptic Site I dimer interface [polypeptide binding]; other site 909946014137 DNA binding site [nucleotide binding] 909946014138 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 909946014139 DNA-binding interface [nucleotide binding]; DNA binding site 909946014140 Integrase core domain; Region: rve; pfam00665 909946014141 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 909946014142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909946014143 Walker A/P-loop; other site 909946014144 Homeodomain-like domain; Region: HTH_23; pfam13384 909946014145 Winged helix-turn helix; Region: HTH_29; pfam13551 909946014146 Homeodomain-like domain; Region: HTH_32; pfam13565 909946014147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 909946014148 DDE superfamily endonuclease; Region: DDE_3; pfam13358 909946014149 transcriptional regulator SpvR; Provisional; Region: PRK15243 909946014150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909946014151 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 909946014152 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 909946014153 virulence protein SpvA; Provisional; Region: PRK15212 909946014154 virulence protein SpvB; Provisional; Region: PRK15244 909946014155 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 909946014156 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 909946014157 active site 909946014158 conformational flexibility of ligand binding pocket; other site 909946014159 ADP-ribosylating toxin turn-turn motif; other site 909946014160 Salmonella virulence-associated 28kDa protein; Region: VRP3; pfam03536 909946014161 virulence protein SpvD; Provisional; Region: PRK15250 909946014162 Transposase IS200 like; Region: Y1_Tnp; pfam01797 909946014163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 909946014164 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 909946014165 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 909946014166 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 909946014167 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 909946014168 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 909946014169 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 909946014170 active site 909946014171 catalytic residues [active] 909946014172 DNA binding site [nucleotide binding] 909946014173 Int/Topo IB signature motif; other site 909946014174 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 909946014175 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 909946014176 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 909946014177 fimbrial protein PefA; Provisional; Region: PRK15214 909946014178 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 909946014179 PapC N-terminal domain; Region: PapC_N; pfam13954 909946014180 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 909946014181 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 909946014182 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 909946014183 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 909946014184 FaeA-like protein; Region: FaeA; pfam04703 909946014185 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909946014186 DNA binding residues [nucleotide binding] 909946014187 dimerization interface [polypeptide binding]; other site 909946014188 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 909946014189 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 909946014190 catalytic residues [active] 909946014191 hinge region; other site 909946014192 alpha helical domain; other site 909946014193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 909946014194 SdiA-regulated; Region: SdiA-regulated; cd09971 909946014195 putative active site [active] 909946014196 resistance to complement killing; Provisional; Region: PRK15240 909946014197 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 909946014198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 909946014199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 909946014200 SdiA-regulated; Region: SdiA-regulated; cd09971 909946014201 replication protein; Provisional; Region: PRK13750 909946014202 RepA leader peptide Tap; Provisional; Region: PRK14745 909946014203 replication protein; Provisional; Region: PRK13702 909946014204 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 909946014205 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 909946014206 putative active site [active] 909946014207 catalytic site [active] 909946014208 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 909946014209 dihydropteroate synthase; Region: DHPS; TIGR01496 909946014210 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 909946014211 substrate binding pocket [chemical binding]; other site 909946014212 dimer interface [polypeptide binding]; other site 909946014213 inhibitor binding site; inhibition site 909946014214 Replication protein C (RepC); Region: RepC; pfam06504 909946014215 AAA domain; Region: AAA_25; pfam13481 909946014216 Hexameric Replicative Helicase RepA. RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125 909946014217 Walker A motif; other site 909946014218 NTP binding site [chemical binding]; other site 909946014219 hexamer interface [polypeptide binding]; other site 909946014220 Walker B motif; other site 909946014221 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 909946014222 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 909946014223 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 909946014224 Phosphotransferase enzyme family; Region: APH; pfam01636 909946014225 active site 909946014226 ATP binding site [chemical binding]; other site 909946014227 antibiotic binding site [chemical binding]; other site 909946014228 RelB antitoxin; Region: RelB; cl01171 909946014229 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 909946014230 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 909946014231 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 909946014232 active site 909946014233 catalytic site [active] 909946014234 substrate binding site [chemical binding]; other site 909946014235 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 909946014236 putative kissing complex interaction region; other site 909946014237 putative RNA binding sites [nucleotide binding]; other site 909946014238 Colicin Ia; Region: Colicin_Ia; pfam11504 909946014239 Colicin pore forming domain; Region: Colicin; pfam01024 909946014240 Phage integrase family; Region: Phage_integrase; pfam00589 909946014241 active site 909946014242 DNA binding site [nucleotide binding] 909946014243 Int/Topo IB signature motif; other site 909946014244 ParA-like protein; Provisional; Region: PHA02518 909946014245 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 909946014246 P-loop; other site 909946014247 Magnesium ion binding site [ion binding]; other site 909946014248 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 909946014249 Mg binding site [ion binding]; other site 909946014250 nucleotide binding site [chemical binding]; other site 909946014251 putative protofilament interface [polypeptide binding]; other site 909946014252 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 909946014253 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 909946014254 putative methylase; Provisional; Region: PRK13699 909946014255 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 909946014256 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 909946014257 Antirestriction protein; Region: Antirestrict; pfam03230 909946014258 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 909946014259 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 909946014260 dimer interface [polypeptide binding]; other site 909946014261 ssDNA binding site [nucleotide binding]; other site 909946014262 tetramer (dimer of dimers) interface [polypeptide binding]; other site 909946014263 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 909946014264 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 909946014265 PsiA protein; Region: PsiA; pfam06952 909946014266 Protein of unknown function (DUF1472); Region: DUF1472; pfam07339 909946014267 Antirestriction protein (ArdA); Region: ArdA; pfam07275 909946014268 hypothetical protein; Provisional; Region: PRK09956 909946014269 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 909946014270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 909946014271 non-specific DNA binding site [nucleotide binding]; other site 909946014272 salt bridge; other site 909946014273 sequence-specific DNA binding site [nucleotide binding]; other site 909946014274 Methyltransferase domain; Region: Methyltransf_27; pfam13708 909946014275 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 909946014276 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 909946014277 dimerization domain [polypeptide binding]; other site 909946014278 dimer interface [polypeptide binding]; other site 909946014279 catalytic residues [active] 909946014280 Hok/gef family; Region: HOK_GEF; pfam01848 909946014281 HEAT repeats; Region: HEAT_2; pfam13646 909946014282 indole-3-acetamide amidohydrolase; Region: PLN02722 909946014283 AAA-like domain; Region: AAA_10; pfam12846 909946014284 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 909946014285 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 909946014286 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 909946014287 PLD-like domain; Region: PLDc_2; pfam13091 909946014288 putative active site [active] 909946014289 catalytic site [active] 909946014290 plasmid transfer ATPase TraJ; Region: plasmid_TraJ; TIGR02525 909946014291 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 909946014292 Walker A motif; other site 909946014293 ATP binding site [chemical binding]; other site 909946014294 Walker B motif; other site 909946014295 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 909946014296 catalytic core [active] 909946014297 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 909946014298 Rci recombinase, C-terminal catalytic domain. Rci enzymes are found in IncI1 incompatibility group plasmids such as R64. These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796 909946014299 catalytic residues [active] 909946014300 Int/Topo IB signature motif; other site 909946014301 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 909946014302 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 909946014303 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 909946014304 N-acetyl-D-glucosamine binding site [chemical binding]; other site 909946014305 catalytic residue [active] 909946014306 PilS N terminal; Region: PilS; pfam08805 909946014307 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 909946014308 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 909946014309 Type II/IV secretion system protein; Region: T2SE; pfam00437 909946014310 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 909946014311 Walker A motif; other site 909946014312 ATP binding site [chemical binding]; other site 909946014313 Walker B motif; other site 909946014314 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 909946014315 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 909946014316 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 909946014317 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 909946014318 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 909946014319 PilM; Region: PilM; pfam07419 909946014320 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 909946014321 Plasmid conjugative transfer protein PilI; Region: PilI; pfam10623 909946014322 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 909946014323 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 909946014324 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 909946014325 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 909946014326 Ash protein family; Region: Phage_ASH; pfam10554