-- dump date   	20140620_055513
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
718274000001	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
718274000002	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
718274000003	putative catalytic residues [active]
718274000004	putative nucleotide binding site [chemical binding]; other site
718274000005	putative aspartate binding site [chemical binding]; other site
718274000006	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
718274000007	dimer interface [polypeptide binding]; other site
718274000008	putative threonine allosteric regulatory site; other site
718274000009	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
718274000010	putative threonine allosteric regulatory site; other site
718274000011	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
718274000012	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
718274000013	homoserine kinase; Provisional; Region: PRK01212
718274000014	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
718274000015	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
718274000016	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
718274000017	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274000018	catalytic residue [active]
718274000019	hypothetical protein; Validated; Region: PRK02101
718274000020	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
718274000021	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
718274000022	transaldolase-like protein; Provisional; Region: PTZ00411
718274000023	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
718274000024	active site
718274000025	dimer interface [polypeptide binding]; other site
718274000026	catalytic residue [active]
718274000027	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
718274000028	MPT binding site; other site
718274000029	trimer interface [polypeptide binding]; other site
718274000030	hypothetical protein; Provisional; Region: PRK10659
718274000031	hypothetical protein; Provisional; Region: PRK10236
718274000032	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
718274000033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
718274000034	Protein of unknown function (DUF2541); Region: DUF2541; pfam10807
718274000035	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
718274000036	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
718274000037	nucleotide binding site [chemical binding]; other site
718274000038	chaperone protein DnaJ; Provisional; Region: PRK10767
718274000039	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
718274000040	HSP70 interaction site [polypeptide binding]; other site
718274000041	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
718274000042	substrate binding site [polypeptide binding]; other site
718274000043	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
718274000044	Zn binding sites [ion binding]; other site
718274000045	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
718274000046	dimer interface [polypeptide binding]; other site
718274000047	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274000048	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274000049	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718274000050	dimerization interface [polypeptide binding]; other site
718274000051	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
718274000052	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
718274000053	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
718274000054	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
718274000055	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
718274000056	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
718274000057	active site
718274000058	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
718274000059	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
718274000060	aromatic chitin/cellulose binding site residues [chemical binding]; other site
718274000061	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
718274000062	Helix-turn-helix domain; Region: HTH_36; pfam13730
718274000063	fimbrial protein BcfA; Provisional; Region: PRK15187
718274000064	fimbrial chaperone protein BcfB; Provisional; Region: PRK15188
718274000065	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274000066	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274000067	outer membrane usher protein; Provisional; Region: PRK15193
718274000068	PapC N-terminal domain; Region: PapC_N; pfam13954
718274000069	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
718274000070	PapC C-terminal domain; Region: PapC_C; pfam13953
718274000071	fimbrial protein BcfD; Provisional; Region: PRK15189
718274000072	fimbrial protein BcfE; Provisional; Region: PRK15190
718274000073	fimbrial protein BcfF; Provisional; Region: PRK15191
718274000074	fimbrial chaperone BcfG; Provisional; Region: PRK15192
718274000075	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274000076	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274000077	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
718274000078	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
718274000079	catalytic residues [active]
718274000080	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
718274000081	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274000082	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274000083	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718274000084	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
718274000085	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
718274000086	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
718274000087	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
718274000088	active site
718274000089	metal binding site [ion binding]; metal-binding site
718274000090	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
718274000091	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
718274000092	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
718274000093	Sulfatase; Region: Sulfatase; pfam00884
718274000094	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
718274000095	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274000096	FeS/SAM binding site; other site
718274000097	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
718274000098	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274000099	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
718274000100	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
718274000101	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
718274000102	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274000103	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
718274000104	putative dimerization interface [polypeptide binding]; other site
718274000105	putative alpha-glucosidase; Provisional; Region: PRK10658
718274000106	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
718274000107	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
718274000108	putative active site [active]
718274000109	putative catalytic site [active]
718274000110	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
718274000111	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
718274000112	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
718274000113	Protein of unknown function (DUF2575); Region: DUF2575; pfam10837
718274000114	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
718274000115	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
718274000116	active site
718274000117	Riboflavin kinase; Region: Flavokinase; smart00904
718274000118	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
718274000119	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718274000120	active site
718274000121	HIGH motif; other site
718274000122	nucleotide binding site [chemical binding]; other site
718274000123	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
718274000124	active site
718274000125	KMSKS motif; other site
718274000126	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
718274000127	tRNA binding surface [nucleotide binding]; other site
718274000128	anticodon binding site; other site
718274000129	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
718274000130	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
718274000131	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
718274000132	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
718274000133	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
718274000134	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
718274000135	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
718274000136	active site
718274000137	tetramer interface [polypeptide binding]; other site
718274000138	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
718274000139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274000140	active site
718274000141	phosphorylation site [posttranslational modification]
718274000142	intermolecular recognition site; other site
718274000143	dimerization interface [polypeptide binding]; other site
718274000144	Transcriptional regulator; Region: CitT; pfam12431
718274000145	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
718274000146	PAS domain; Region: PAS; smart00091
718274000147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274000148	ATP binding site [chemical binding]; other site
718274000149	Mg2+ binding site [ion binding]; other site
718274000150	G-X-G motif; other site
718274000151	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
718274000152	oxaloacetate decarboxylase; Provisional; Region: PRK14040
718274000153	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
718274000154	active site
718274000155	catalytic residues [active]
718274000156	metal binding site [ion binding]; metal-binding site
718274000157	homodimer binding site [polypeptide binding]; other site
718274000158	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
718274000159	carboxyltransferase (CT) interaction site; other site
718274000160	biotinylation site [posttranslational modification]; other site
718274000161	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
718274000162	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
718274000163	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
718274000164	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
718274000165	putative active site [active]
718274000166	(T/H)XGH motif; other site
718274000167	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
718274000168	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
718274000169	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
718274000170	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
718274000171	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
718274000172	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
718274000173	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
718274000174	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
718274000175	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
718274000176	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
718274000177	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
718274000178	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
718274000179	catalytic site [active]
718274000180	subunit interface [polypeptide binding]; other site
718274000181	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
718274000182	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
718274000183	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
718274000184	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
718274000185	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
718274000186	ATP-grasp domain; Region: ATP-grasp_4; cl17255
718274000187	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
718274000188	IMP binding site; other site
718274000189	dimer interface [polypeptide binding]; other site
718274000190	interdomain contacts; other site
718274000191	partial ornithine binding site; other site
718274000192	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
718274000193	carnitine operon protein CaiE; Provisional; Region: PRK13627
718274000194	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
718274000195	putative trimer interface [polypeptide binding]; other site
718274000196	putative metal binding site [ion binding]; other site
718274000197	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
718274000198	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
718274000199	substrate binding site [chemical binding]; other site
718274000200	oxyanion hole (OAH) forming residues; other site
718274000201	trimer interface [polypeptide binding]; other site
718274000202	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
718274000203	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
718274000204	acyl-activating enzyme (AAE) consensus motif; other site
718274000205	putative AMP binding site [chemical binding]; other site
718274000206	putative active site [active]
718274000207	putative CoA binding site [chemical binding]; other site
718274000208	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
718274000209	CoA-transferase family III; Region: CoA_transf_3; pfam02515
718274000210	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
718274000211	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
718274000212	active site
718274000213	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
718274000214	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
718274000215	Ligand binding site [chemical binding]; other site
718274000216	Electron transfer flavoprotein domain; Region: ETF; pfam01012
718274000217	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
718274000218	Electron transfer flavoprotein domain; Region: ETF; smart00893
718274000219	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
718274000220	putative oxidoreductase FixC; Provisional; Region: PRK10157
718274000221	ferredoxin-like protein FixX; Provisional; Region: PRK15449
718274000222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274000223	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
718274000224	putative substrate translocation pore; other site
718274000225	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
718274000226	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
718274000227	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
718274000228	Sulfatase; Region: Sulfatase; cl17466
718274000229	Sulfatase; Region: Sulfatase; cl17466
718274000230	Sulfatase; Region: Sulfatase; cl17466
718274000231	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
718274000232	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
718274000233	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
718274000234	TrkA-N domain; Region: TrkA_N; pfam02254
718274000235	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
718274000236	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
718274000237	folate binding site [chemical binding]; other site
718274000238	NADP+ binding site [chemical binding]; other site
718274000239	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
718274000240	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
718274000241	active site
718274000242	metal binding site [ion binding]; metal-binding site
718274000243	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
718274000244	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
718274000245	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
718274000246	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
718274000247	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
718274000248	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
718274000249	SurA N-terminal domain; Region: SurA_N; pfam09312
718274000250	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
718274000251	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
718274000252	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
718274000253	OstA-like protein; Region: OstA; pfam03968
718274000254	Organic solvent tolerance protein; Region: OstA_C; pfam04453
718274000255	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
718274000256	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
718274000257	putative metal binding site [ion binding]; other site
718274000258	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
718274000259	HSP70 interaction site [polypeptide binding]; other site
718274000260	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
718274000261	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
718274000262	active site
718274000263	ATP-dependent helicase HepA; Validated; Region: PRK04914
718274000264	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718274000265	ATP binding site [chemical binding]; other site
718274000266	putative Mg++ binding site [ion binding]; other site
718274000267	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274000268	nucleotide binding region [chemical binding]; other site
718274000269	ATP-binding site [chemical binding]; other site
718274000270	DNA polymerase II; Reviewed; Region: PRK05762
718274000271	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
718274000272	active site
718274000273	catalytic site [active]
718274000274	substrate binding site [chemical binding]; other site
718274000275	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
718274000276	active site
718274000277	metal-binding site
718274000278	Uncharacterized conserved protein [Function unknown]; Region: COG1434
718274000279	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
718274000280	putative active site [active]
718274000281	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
718274000282	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
718274000283	intersubunit interface [polypeptide binding]; other site
718274000284	active site
718274000285	Zn2+ binding site [ion binding]; other site
718274000286	L-arabinose isomerase; Provisional; Region: PRK02929
718274000287	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
718274000288	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
718274000289	trimer interface [polypeptide binding]; other site
718274000290	putative substrate binding site [chemical binding]; other site
718274000291	putative metal binding site [ion binding]; other site
718274000292	ribulokinase; Provisional; Region: PRK04123
718274000293	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
718274000294	N- and C-terminal domain interface [polypeptide binding]; other site
718274000295	active site
718274000296	MgATP binding site [chemical binding]; other site
718274000297	catalytic site [active]
718274000298	metal binding site [ion binding]; metal-binding site
718274000299	carbohydrate binding site [chemical binding]; other site
718274000300	homodimer interface [polypeptide binding]; other site
718274000301	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
718274000302	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718274000303	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274000304	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274000305	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
718274000306	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
718274000307	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
718274000308	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
718274000309	Walker A/P-loop; other site
718274000310	ATP binding site [chemical binding]; other site
718274000311	Q-loop/lid; other site
718274000312	ABC transporter signature motif; other site
718274000313	Walker B; other site
718274000314	D-loop; other site
718274000315	H-loop/switch region; other site
718274000316	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
718274000317	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274000318	dimer interface [polypeptide binding]; other site
718274000319	conserved gate region; other site
718274000320	putative PBP binding loops; other site
718274000321	ABC-ATPase subunit interface; other site
718274000322	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274000323	dimer interface [polypeptide binding]; other site
718274000324	conserved gate region; other site
718274000325	putative PBP binding loops; other site
718274000326	ABC-ATPase subunit interface; other site
718274000327	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
718274000328	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
718274000329	transcriptional regulator SgrR; Provisional; Region: PRK13626
718274000330	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
718274000331	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
718274000332	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
718274000333	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
718274000334	substrate binding site [chemical binding]; other site
718274000335	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
718274000336	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
718274000337	substrate binding site [chemical binding]; other site
718274000338	ligand binding site [chemical binding]; other site
718274000339	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
718274000340	tartrate dehydrogenase; Region: TTC; TIGR02089
718274000341	2-isopropylmalate synthase; Validated; Region: PRK00915
718274000342	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
718274000343	active site
718274000344	catalytic residues [active]
718274000345	metal binding site [ion binding]; metal-binding site
718274000346	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
718274000347	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
718274000348	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274000349	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
718274000350	putative substrate binding pocket [chemical binding]; other site
718274000351	putative dimerization interface [polypeptide binding]; other site
718274000352	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
718274000353	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
718274000354	dimer interface [polypeptide binding]; other site
718274000355	PYR/PP interface [polypeptide binding]; other site
718274000356	TPP binding site [chemical binding]; other site
718274000357	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
718274000358	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
718274000359	TPP-binding site [chemical binding]; other site
718274000360	dimer interface [polypeptide binding]; other site
718274000361	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
718274000362	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
718274000363	putative valine binding site [chemical binding]; other site
718274000364	dimer interface [polypeptide binding]; other site
718274000365	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
718274000366	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
718274000367	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274000368	DNA binding site [nucleotide binding]
718274000369	domain linker motif; other site
718274000370	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
718274000371	dimerization interface [polypeptide binding]; other site
718274000372	ligand binding site [chemical binding]; other site
718274000373	mraZ protein; Region: TIGR00242
718274000374	MraZ protein; Region: MraZ; pfam02381
718274000375	MraZ protein; Region: MraZ; pfam02381
718274000376	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
718274000377	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
718274000378	cell division protein FtsL; Provisional; Region: PRK10772
718274000379	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
718274000380	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
718274000381	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
718274000382	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
718274000383	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
718274000384	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718274000385	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718274000386	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
718274000387	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
718274000388	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718274000389	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718274000390	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
718274000391	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
718274000392	Mg++ binding site [ion binding]; other site
718274000393	putative catalytic motif [active]
718274000394	putative substrate binding site [chemical binding]; other site
718274000395	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
718274000396	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718274000397	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718274000398	cell division protein FtsW; Provisional; Region: PRK10774
718274000399	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
718274000400	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
718274000401	active site
718274000402	homodimer interface [polypeptide binding]; other site
718274000403	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
718274000404	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
718274000405	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718274000406	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718274000407	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
718274000408	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
718274000409	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
718274000410	cell division protein FtsQ; Provisional; Region: PRK10775
718274000411	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
718274000412	Cell division protein FtsQ; Region: FtsQ; pfam03799
718274000413	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
718274000414	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718274000415	Cell division protein FtsA; Region: FtsA; pfam14450
718274000416	cell division protein FtsZ; Validated; Region: PRK09330
718274000417	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
718274000418	nucleotide binding site [chemical binding]; other site
718274000419	SulA interaction site; other site
718274000420	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
718274000421	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
718274000422	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
718274000423	SecA regulator SecM; Provisional; Region: PRK02943
718274000424	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
718274000425	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
718274000426	SEC-C motif; Region: SEC-C; pfam02810
718274000427	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
718274000428	active site
718274000429	8-oxo-dGMP binding site [chemical binding]; other site
718274000430	nudix motif; other site
718274000431	metal binding site [ion binding]; metal-binding site
718274000432	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
718274000433	DNA gyrase inhibitor; Reviewed; Region: PRK00418
718274000434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
718274000435	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
718274000436	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
718274000437	CoA-binding site [chemical binding]; other site
718274000438	ATP-binding [chemical binding]; other site
718274000439	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
718274000440	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
718274000441	active site
718274000442	type IV pilin biogenesis protein; Provisional; Region: PRK10573
718274000443	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
718274000444	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
718274000445	hypothetical protein; Provisional; Region: PRK10436
718274000446	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
718274000447	Walker A motif; other site
718274000448	ATP binding site [chemical binding]; other site
718274000449	Walker B motif; other site
718274000450	putative major pilin subunit; Provisional; Region: PRK10574
718274000451	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
718274000452	Pilin (bacterial filament); Region: Pilin; pfam00114
718274000453	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
718274000454	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
718274000455	dimerization interface [polypeptide binding]; other site
718274000456	active site
718274000457	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
718274000458	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
718274000459	amidase catalytic site [active]
718274000460	Zn binding residues [ion binding]; other site
718274000461	substrate binding site [chemical binding]; other site
718274000462	regulatory protein AmpE; Provisional; Region: PRK10987
718274000463	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
718274000464	active site
718274000465	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
718274000466	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274000467	putative substrate translocation pore; other site
718274000468	aromatic amino acid transporter; Provisional; Region: PRK10238
718274000469	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
718274000470	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274000471	DNA-binding site [nucleotide binding]; DNA binding site
718274000472	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
718274000473	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
718274000474	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
718274000475	dimer interface [polypeptide binding]; other site
718274000476	TPP-binding site [chemical binding]; other site
718274000477	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
718274000478	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
718274000479	E3 interaction surface; other site
718274000480	lipoyl attachment site [posttranslational modification]; other site
718274000481	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
718274000482	E3 interaction surface; other site
718274000483	lipoyl attachment site [posttranslational modification]; other site
718274000484	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
718274000485	E3 interaction surface; other site
718274000486	lipoyl attachment site [posttranslational modification]; other site
718274000487	e3 binding domain; Region: E3_binding; pfam02817
718274000488	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
718274000489	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
718274000490	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
718274000491	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274000492	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
718274000493	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
718274000494	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
718274000495	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
718274000496	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
718274000497	substrate binding site [chemical binding]; other site
718274000498	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
718274000499	substrate binding site [chemical binding]; other site
718274000500	ligand binding site [chemical binding]; other site
718274000501	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
718274000502	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
718274000503	hypothetical protein; Provisional; Region: PRK05248
718274000504	2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460
718274000505	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
718274000506	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
718274000507	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
718274000508	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
718274000509	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
718274000510	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274000511	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
718274000512	spermidine synthase; Provisional; Region: PRK00811
718274000513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274000514	S-adenosylmethionine binding site [chemical binding]; other site
718274000515	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
718274000516	multicopper oxidase; Provisional; Region: PRK10965
718274000517	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
718274000518	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
718274000519	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
718274000520	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
718274000521	Trp docking motif [polypeptide binding]; other site
718274000522	putative active site [active]
718274000523	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
718274000524	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718274000525	active site
718274000526	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
718274000527	active site clefts [active]
718274000528	zinc binding site [ion binding]; other site
718274000529	dimer interface [polypeptide binding]; other site
718274000530	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
718274000531	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
718274000532	Walker A/P-loop; other site
718274000533	ATP binding site [chemical binding]; other site
718274000534	Q-loop/lid; other site
718274000535	ABC transporter signature motif; other site
718274000536	Walker B; other site
718274000537	D-loop; other site
718274000538	H-loop/switch region; other site
718274000539	inner membrane transport permease; Provisional; Region: PRK15066
718274000540	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
718274000541	putative fimbrial protein StiH; Provisional; Region: PRK15297
718274000542	fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298
718274000543	PapC N-terminal domain; Region: PapC_N; pfam13954
718274000544	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
718274000545	PapC C-terminal domain; Region: PapC_C; pfam13953
718274000546	fimbrial chaperone protein StiB; Provisional; Region: PRK15299
718274000547	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274000548	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274000549	fimbrial protein StiA; Provisional; Region: PRK15300
718274000550	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
718274000551	active pocket/dimerization site; other site
718274000552	active site
718274000553	phosphorylation site [posttranslational modification]
718274000554	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
718274000555	putative active site [active]
718274000556	putative metal binding site [ion binding]; other site
718274000557	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
718274000558	tetramerization interface [polypeptide binding]; other site
718274000559	active site
718274000560	Pantoate-beta-alanine ligase; Region: PanC; cd00560
718274000561	pantoate--beta-alanine ligase; Region: panC; TIGR00018
718274000562	active site
718274000563	ATP-binding site [chemical binding]; other site
718274000564	pantoate-binding site; other site
718274000565	HXXH motif; other site
718274000566	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
718274000567	oligomerization interface [polypeptide binding]; other site
718274000568	active site
718274000569	metal binding site [ion binding]; metal-binding site
718274000570	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
718274000571	catalytic center binding site [active]
718274000572	ATP binding site [chemical binding]; other site
718274000573	poly(A) polymerase; Region: pcnB; TIGR01942
718274000574	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
718274000575	active site
718274000576	NTP binding site [chemical binding]; other site
718274000577	metal binding triad [ion binding]; metal-binding site
718274000578	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
718274000579	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
718274000580	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
718274000581	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
718274000582	active site
718274000583	nucleotide binding site [chemical binding]; other site
718274000584	HIGH motif; other site
718274000585	KMSKS motif; other site
718274000586	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
718274000587	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
718274000588	2'-5' RNA ligase; Provisional; Region: PRK15124
718274000589	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
718274000590	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
718274000591	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
718274000592	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718274000593	ATP binding site [chemical binding]; other site
718274000594	putative Mg++ binding site [ion binding]; other site
718274000595	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274000596	nucleotide binding region [chemical binding]; other site
718274000597	ATP-binding site [chemical binding]; other site
718274000598	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
718274000599	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
718274000600	Transglycosylase; Region: Transgly; pfam00912
718274000601	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
718274000602	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
718274000603	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
718274000604	N-terminal plug; other site
718274000605	ligand-binding site [chemical binding]; other site
718274000606	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
718274000607	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
718274000608	Walker A/P-loop; other site
718274000609	ATP binding site [chemical binding]; other site
718274000610	Q-loop/lid; other site
718274000611	ABC transporter signature motif; other site
718274000612	Walker B; other site
718274000613	D-loop; other site
718274000614	H-loop/switch region; other site
718274000615	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
718274000616	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
718274000617	siderophore binding site; other site
718274000618	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
718274000619	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718274000620	ABC-ATPase subunit  interface; other site
718274000621	dimer interface [polypeptide binding]; other site
718274000622	putative PBP binding regions; other site
718274000623	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718274000624	ABC-ATPase subunit  interface; other site
718274000625	dimer interface [polypeptide binding]; other site
718274000626	putative PBP binding regions; other site
718274000627	putative fimbrial subunit StfA; Provisional; Region: PRK15283
718274000628	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
718274000629	PapC N-terminal domain; Region: PapC_N; pfam13954
718274000630	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
718274000631	PapC C-terminal domain; Region: PapC_C; pfam13953
718274000632	putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285
718274000633	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274000634	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274000635	putative minor fimbrial subunit StfE; Provisional; Region: PRK15286
718274000636	putative minor fimbrial subunit StfF; Provisional; Region: PRK15287
718274000637	putative minor fimbrial subunit StfG; Provisional; Region: PRK15288
718274000638	Protein of unknown function (DUF2544); Region: DUF2544; pfam11245
718274000639	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
718274000640	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
718274000641	inhibitor-cofactor binding pocket; inhibition site
718274000642	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274000643	catalytic residue [active]
718274000644	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
718274000645	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
718274000646	Cl- selectivity filter; other site
718274000647	Cl- binding residues [ion binding]; other site
718274000648	pore gating glutamate residue; other site
718274000649	dimer interface [polypeptide binding]; other site
718274000650	H+/Cl- coupling transport residue; other site
718274000651	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
718274000652	hypothetical protein; Provisional; Region: PRK10578
718274000653	UPF0126 domain; Region: UPF0126; pfam03458
718274000654	UPF0126 domain; Region: UPF0126; pfam03458
718274000655	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
718274000656	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
718274000657	cobalamin binding residues [chemical binding]; other site
718274000658	putative BtuC binding residues; other site
718274000659	dimer interface [polypeptide binding]; other site
718274000660	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
718274000661	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
718274000662	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
718274000663	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718274000664	Zn2+ binding site [ion binding]; other site
718274000665	Mg2+ binding site [ion binding]; other site
718274000666	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
718274000667	serine endoprotease; Provisional; Region: PRK10942
718274000668	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
718274000669	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
718274000670	protein binding site [polypeptide binding]; other site
718274000671	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
718274000672	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
718274000673	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
718274000674	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
718274000675	hypothetical protein; Provisional; Region: PRK13677
718274000676	shikimate transporter; Provisional; Region: PRK09952
718274000677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274000678	putative substrate translocation pore; other site
718274000679	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
718274000680	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
718274000681	trimer interface [polypeptide binding]; other site
718274000682	active site
718274000683	substrate binding site [chemical binding]; other site
718274000684	CoA binding site [chemical binding]; other site
718274000685	PII uridylyl-transferase; Provisional; Region: PRK05007
718274000686	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
718274000687	metal binding triad; other site
718274000688	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
718274000689	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718274000690	Zn2+ binding site [ion binding]; other site
718274000691	Mg2+ binding site [ion binding]; other site
718274000692	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
718274000693	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
718274000694	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
718274000695	active site
718274000696	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
718274000697	rRNA interaction site [nucleotide binding]; other site
718274000698	S8 interaction site; other site
718274000699	putative laminin-1 binding site; other site
718274000700	elongation factor Ts; Provisional; Region: tsf; PRK09377
718274000701	UBA/TS-N domain; Region: UBA; pfam00627
718274000702	Elongation factor TS; Region: EF_TS; pfam00889
718274000703	Elongation factor TS; Region: EF_TS; pfam00889
718274000704	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
718274000705	putative nucleotide binding site [chemical binding]; other site
718274000706	uridine monophosphate binding site [chemical binding]; other site
718274000707	homohexameric interface [polypeptide binding]; other site
718274000708	ribosome recycling factor; Reviewed; Region: frr; PRK00083
718274000709	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
718274000710	hinge region; other site
718274000711	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
718274000712	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
718274000713	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
718274000714	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
718274000715	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
718274000716	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
718274000717	catalytic residue [active]
718274000718	putative FPP diphosphate  binding site; other site
718274000719	putative FPP binding hydrophobic cleft; other site
718274000720	dimer interface [polypeptide binding]; other site
718274000721	putative IPP diphosphate binding site; other site
718274000722	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
718274000723	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
718274000724	zinc metallopeptidase RseP; Provisional; Region: PRK10779
718274000725	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
718274000726	active site
718274000727	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
718274000728	protein binding site [polypeptide binding]; other site
718274000729	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
718274000730	protein binding site [polypeptide binding]; other site
718274000731	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
718274000732	putative substrate binding region [chemical binding]; other site
718274000733	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
718274000734	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
718274000735	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
718274000736	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
718274000737	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
718274000738	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
718274000739	Surface antigen; Region: Bac_surface_Ag; pfam01103
718274000740	periplasmic chaperone; Provisional; Region: PRK10780
718274000741	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
718274000742	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
718274000743	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
718274000744	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
718274000745	trimer interface [polypeptide binding]; other site
718274000746	active site
718274000747	UDP-GlcNAc binding site [chemical binding]; other site
718274000748	lipid binding site [chemical binding]; lipid-binding site
718274000749	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
718274000750	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
718274000751	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
718274000752	active site
718274000753	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
718274000754	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
718274000755	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
718274000756	RNA/DNA hybrid binding site [nucleotide binding]; other site
718274000757	active site
718274000758	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
718274000759	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
718274000760	putative active site [active]
718274000761	putative PHP Thumb interface [polypeptide binding]; other site
718274000762	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
718274000763	generic binding surface II; other site
718274000764	generic binding surface I; other site
718274000765	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
718274000766	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
718274000767	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
718274000768	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
718274000769	putative sugar binding site [chemical binding]; other site
718274000770	catalytic residues [active]
718274000771	PKD domain; Region: PKD; pfam00801
718274000772	lysine decarboxylase LdcC; Provisional; Region: PRK15399
718274000773	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
718274000774	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
718274000775	homodimer interface [polypeptide binding]; other site
718274000776	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274000777	catalytic residue [active]
718274000778	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
718274000779	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
718274000780	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
718274000781	putative metal binding site [ion binding]; other site
718274000782	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
718274000783	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
718274000784	Ligand Binding Site [chemical binding]; other site
718274000785	TilS substrate binding domain; Region: TilS; pfam09179
718274000786	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
718274000787	Rho-binding antiterminator; Provisional; Region: PRK11625
718274000788	hypothetical protein; Provisional; Region: PRK04964
718274000789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
718274000790	hypothetical protein; Provisional; Region: PRK09256
718274000791	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
718274000792	potential frameshift: common BLAST hit: gi|194446048|ref|YP_002039481.1| lipoprotein involved with copper homeostasis and adhesion
718274000793	NlpE N-terminal domain; Region: NlpE; pfam04170
718274000794	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
718274000795	prolyl-tRNA synthetase; Provisional; Region: PRK09194
718274000796	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
718274000797	dimer interface [polypeptide binding]; other site
718274000798	motif 1; other site
718274000799	active site
718274000800	motif 2; other site
718274000801	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
718274000802	putative deacylase active site [active]
718274000803	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
718274000804	active site
718274000805	motif 3; other site
718274000806	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
718274000807	anticodon binding site; other site
718274000808	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
718274000809	homodimer interaction site [polypeptide binding]; other site
718274000810	cofactor binding site; other site
718274000811	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
718274000812	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
718274000813	lipoprotein, YaeC family; Region: TIGR00363
718274000814	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274000815	dimer interface [polypeptide binding]; other site
718274000816	conserved gate region; other site
718274000817	ABC-ATPase subunit interface; other site
718274000818	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
718274000819	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
718274000820	Walker A/P-loop; other site
718274000821	ATP binding site [chemical binding]; other site
718274000822	Q-loop/lid; other site
718274000823	ABC transporter signature motif; other site
718274000824	Walker B; other site
718274000825	D-loop; other site
718274000826	H-loop/switch region; other site
718274000827	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
718274000828	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
718274000829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274000830	active site
718274000831	motif I; other site
718274000832	motif II; other site
718274000833	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718274000834	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718274000835	active site
718274000836	catalytic tetrad [active]
718274000837	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274000838	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274000839	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
718274000840	putative effector binding pocket; other site
718274000841	dimerization interface [polypeptide binding]; other site
718274000842	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
718274000843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274000844	putative substrate translocation pore; other site
718274000845	hypothetical protein; Provisional; Region: PRK05421
718274000846	putative catalytic site [active]
718274000847	putative metal binding site [ion binding]; other site
718274000848	putative phosphate binding site [ion binding]; other site
718274000849	putative catalytic site [active]
718274000850	putative phosphate binding site [ion binding]; other site
718274000851	putative metal binding site [ion binding]; other site
718274000852	Methyltransferase domain; Region: Methyltransf_23; pfam13489
718274000853	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274000854	S-adenosylmethionine binding site [chemical binding]; other site
718274000855	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
718274000856	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718274000857	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718274000858	catalytic residue [active]
718274000859	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
718274000860	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718274000861	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
718274000862	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718274000863	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
718274000864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274000865	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
718274000866	RNA/DNA hybrid binding site [nucleotide binding]; other site
718274000867	active site
718274000868	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
718274000869	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
718274000870	active site
718274000871	catalytic site [active]
718274000872	substrate binding site [chemical binding]; other site
718274000873	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
718274000874	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
718274000875	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
718274000876	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
718274000877	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
718274000878	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
718274000879	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
718274000880	ImpE protein; Region: ImpE; pfam07024
718274000881	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
718274000882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274000883	Walker A motif; other site
718274000884	ATP binding site [chemical binding]; other site
718274000885	Walker B motif; other site
718274000886	arginine finger; other site
718274000887	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274000888	Walker A motif; other site
718274000889	ATP binding site [chemical binding]; other site
718274000890	Walker B motif; other site
718274000891	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
718274000892	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
718274000893	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
718274000894	Protein of unknown function (DUF877); Region: DUF877; pfam05943
718274000895	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
718274000896	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
718274000897	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
718274000898	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
718274000899	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
718274000900	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
718274000901	hypothetical protein; Provisional; Region: PRK08126
718274000902	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
718274000903	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
718274000904	ligand binding site [chemical binding]; other site
718274000905	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
718274000906	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
718274000907	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
718274000908	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
718274000909	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893
718274000910	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
718274000911	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
718274000912	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
718274000913	Uncharacterized conserved protein [Function unknown]; Region: COG5435
718274000914	PAAR motif; Region: PAAR_motif; pfam05488
718274000915	RHS Repeat; Region: RHS_repeat; pfam05593
718274000916	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
718274000917	RHS Repeat; Region: RHS_repeat; pfam05593
718274000918	RHS Repeat; Region: RHS_repeat; pfam05593
718274000919	RHS protein; Region: RHS; pfam03527
718274000920	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
718274000921	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
718274000922	RHS protein; Region: RHS; pfam03527
718274000923	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
718274000924	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446
718274000925	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446
718274000926	Transposase; Region: HTH_Tnp_1; cl17663
718274000927	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
718274000928	Integrase core domain; Region: rve_3; pfam13683
718274000929	Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221
718274000930	pili assembly chaperone protein SafB; Provisional; Region: PRK15224
718274000931	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274000932	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274000933	pilin outer membrane usher protein SafC; Provisional; Region: PRK15223
718274000934	PapC N-terminal domain; Region: PapC_N; pfam13954
718274000935	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
718274000936	PapC C-terminal domain; Region: PapC_C; pfam13953
718274000937	putative pilin structural protein SafD; Provisional; Region: PRK15222
718274000938	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
718274000939	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
718274000940	putative active site [active]
718274000941	putative metal binding site [ion binding]; other site
718274000942	PerC transcriptional activator; Region: PerC; pfam06069
718274000943	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274000944	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274000945	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718274000946	dimerization interface [polypeptide binding]; other site
718274000947	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
718274000948	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
718274000949	dimer interface [polypeptide binding]; other site
718274000950	C-N hydrolase family amidase; Provisional; Region: PRK10438
718274000951	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
718274000952	putative active site [active]
718274000953	catalytic triad [active]
718274000954	dimer interface [polypeptide binding]; other site
718274000955	multimer interface [polypeptide binding]; other site
718274000956	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
718274000957	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
718274000958	active site
718274000959	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
718274000960	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
718274000961	dimer interface [polypeptide binding]; other site
718274000962	active site
718274000963	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
718274000964	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
718274000965	putative active site [active]
718274000966	putative dimer interface [polypeptide binding]; other site
718274000967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
718274000968	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
718274000969	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
718274000970	active site
718274000971	DNA polymerase IV; Validated; Region: PRK02406
718274000972	DNA binding site [nucleotide binding]
718274000973	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
718274000974	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
718274000975	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
718274000976	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
718274000977	metal binding site [ion binding]; metal-binding site
718274000978	dimer interface [polypeptide binding]; other site
718274000979	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718274000980	active site
718274000981	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
718274000982	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
718274000983	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
718274000984	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
718274000985	trimer interface [polypeptide binding]; other site
718274000986	eyelet of channel; other site
718274000987	gamma-glutamyl kinase; Provisional; Region: PRK05429
718274000988	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
718274000989	nucleotide binding site [chemical binding]; other site
718274000990	homotetrameric interface [polypeptide binding]; other site
718274000991	putative phosphate binding site [ion binding]; other site
718274000992	putative allosteric binding site; other site
718274000993	PUA domain; Region: PUA; pfam01472
718274000994	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
718274000995	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
718274000996	putative catalytic cysteine [active]
718274000997	prophage region Salmonella seroconverting phage
718274000998	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
718274000999	P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192
718274001000	Int/Topo IB signature motif; other site
718274001001	Helix-turn-helix domain; Region: HTH_17; pfam12728
718274001002	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
718274001003	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
718274001004	Protein of unknown function (DUF551); Region: DUF551; pfam04448
718274001005	Protein of unknown function (DUF2737); Region: DUF2737; pfam10930
718274001006	Protein of unknown function (DUF2856); Region: DUF2856; pfam11043
718274001007	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
718274001008	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
718274001009	Lambda Phage CIII; Region: Lambda_CIII; pfam02061
718274001010	hypothetical protein; Region: PHA01516
718274001011	Antirestriction protein Ral; Region: Ral; pfam11058
718274001012	Superinfection exclusion protein B; Region: SieB; pfam14163
718274001013	P63C domain; Region: P63C; pfam10546
718274001014	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274001015	non-specific DNA binding site [nucleotide binding]; other site
718274001016	Predicted transcriptional regulator [Transcription]; Region: COG2932
718274001017	salt bridge; other site
718274001018	sequence-specific DNA binding site [nucleotide binding]; other site
718274001019	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
718274001020	Catalytic site [active]
718274001021	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
718274001022	Bacteriophage CII protein; Region: Phage_CII; pfam05269
718274001023	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
718274001024	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
718274001025	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
718274001026	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
718274001027	Walker A motif; other site
718274001028	ATP binding site [chemical binding]; other site
718274001029	Walker B motif; other site
718274001030	DNA binding loops [nucleotide binding]
718274001031	NinB protein; Region: NinB; pfam05772
718274001032	NINE Protein; Region: NinE; pfam05322
718274001033	Protein of unknown function (DUF2591); Region: DUF2591; cl11584
718274001034	NinF protein; Region: NinF; pfam05810
718274001035	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
718274001036	Phage NinH protein; Region: Phage_NinH; pfam06322
718274001037	Antitermination protein; Region: Antiterm; pfam03589
718274001038	Antitermination protein; Region: Antiterm; pfam03589
718274001039	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
718274001040	catalytic residues [active]
718274001041	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
718274001042	KilA-N domain; Region: KilA-N; pfam04383
718274001043	hypothetical protein; Region: PHA00780
718274001044	hypothetical protein; Region: PHA00527
718274001045	Terminase-like family; Region: Terminase_6; pfam03237
718274001046	Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565
718274001047	Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306
718274001048	coat protein; Region: PHA01511
718274001049	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
718274001050	P22 tail accessory factor; Region: P22_Tail-4; pfam11650
718274001051	Phage stabilisation protein; Region: Phage_stabilise; pfam11134
718274001052	Protein of unknown function (DUF2824); Region: DUF2824; pfam11039
718274001053	Mnt; Region: mnt; PHA01513
718274001054	Arc-like DNA binding domain; Region: Arc; pfam03869
718274001055	Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423
718274001056	Head binding; Region: Head_binding; pfam09008
718274001057	Salmonella phage P22 tail-spike; Region: PhageP22-tail; pfam09251
718274001058	O-antigen conversion protein C; Region: PHA01514
718274001059	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
718274001060	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
718274001061	Ligand binding site; other site
718274001062	Putative Catalytic site; other site
718274001063	DXD motif; other site
718274001064	Predicted membrane protein [Function unknown]; Region: COG2246
718274001065	HTH-like domain; Region: HTH_21; pfam13276
718274001066	Integrase core domain; Region: rve; pfam00665
718274001067	Integrase core domain; Region: rve_2; pfam13333
718274001068	potential frameshift: common BLAST hit: gi|197247887|ref|YP_002145307.1| glycerol dehydratase reactivation factor large subunit
718274001069	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
718274001070	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
718274001071	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
718274001072	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
718274001073	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274001074	putative substrate translocation pore; other site
718274001075	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
718274001076	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
718274001077	substrate binding site [chemical binding]; other site
718274001078	ligand binding site [chemical binding]; other site
718274001079	3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066
718274001080	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
718274001081	hypothetical protein; Provisional; Region: PRK14812
718274001082	substrate binding site [chemical binding]; other site
718274001083	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
718274001084	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
718274001085	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
718274001086	transcriptional activator TtdR; Provisional; Region: PRK09801
718274001087	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274001088	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
718274001089	putative effector binding pocket; other site
718274001090	putative dimerization interface [polypeptide binding]; other site
718274001091	fimbrial assembly chaperone StbE; Provisional; Region: PRK15246
718274001092	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274001093	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274001094	putative fimbrial usher protein StbD; Provisional; Region: PRK15247
718274001095	fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248
718274001096	PapC N-terminal domain; Region: PapC_N; pfam13954
718274001097	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
718274001098	PapC C-terminal domain; Region: PapC_C; pfam13953
718274001099	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274001100	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
718274001101	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274001102	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274001103	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274001104	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274001105	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
718274001106	DNA binding site [nucleotide binding]
718274001107	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
718274001108	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
718274001109	DNA binding residues [nucleotide binding]
718274001110	dimerization interface [polypeptide binding]; other site
718274001111	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
718274001112	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
718274001113	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
718274001114	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
718274001115	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718274001116	HlyD family secretion protein; Region: HlyD_3; pfam13437
718274001117	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
718274001118	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718274001119	metal-binding site [ion binding]
718274001120	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718274001121	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274001122	motif II; other site
718274001123	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
718274001124	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
718274001125	DNA binding residues [nucleotide binding]
718274001126	dimer interface [polypeptide binding]; other site
718274001127	copper binding site [ion binding]; other site
718274001128	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718274001129	metal-binding site [ion binding]
718274001130	putative sialic acid transporter; Region: 2A0112; TIGR00891
718274001131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274001132	putative substrate translocation pore; other site
718274001133	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
718274001134	DNA methylase; Region: N6_N4_Mtase; cl17433
718274001135	DNA methylase; Region: N6_N4_Mtase; pfam01555
718274001136	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
718274001137	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
718274001138	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
718274001139	VRR-NUC domain; Region: VRR_NUC; pfam08774
718274001140	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
718274001141	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
718274001142	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
718274001143	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
718274001144	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718274001145	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
718274001146	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
718274001147	N-terminal plug; other site
718274001148	ligand-binding site [chemical binding]; other site
718274001149	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
718274001150	hypothetical protein; Provisional; Region: PRK09929
718274001151	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
718274001152	Propionate catabolism activator; Region: PrpR_N; pfam06506
718274001153	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274001154	Walker A motif; other site
718274001155	ATP binding site [chemical binding]; other site
718274001156	Walker B motif; other site
718274001157	arginine finger; other site
718274001158	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
718274001159	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
718274001160	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
718274001161	tetramer interface [polypeptide binding]; other site
718274001162	active site
718274001163	Mg2+/Mn2+ binding site [ion binding]; other site
718274001164	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
718274001165	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
718274001166	dimer interface [polypeptide binding]; other site
718274001167	active site
718274001168	citrylCoA binding site [chemical binding]; other site
718274001169	oxalacetate/citrate binding site [chemical binding]; other site
718274001170	coenzyme A binding site [chemical binding]; other site
718274001171	catalytic triad [active]
718274001172	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
718274001173	2-methylcitrate dehydratase; Region: prpD; TIGR02330
718274001174	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
718274001175	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
718274001176	acyl-activating enzyme (AAE) consensus motif; other site
718274001177	AMP binding site [chemical binding]; other site
718274001178	active site
718274001179	CoA binding site [chemical binding]; other site
718274001180	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
718274001181	dimer interface [polypeptide binding]; other site
718274001182	active site
718274001183	Schiff base residues; other site
718274001184	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
718274001185	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
718274001186	Autotransporter beta-domain; Region: Autotransporter; pfam03797
718274001187	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
718274001188	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
718274001189	ligand binding site [chemical binding]; other site
718274001190	flexible hinge region; other site
718274001191	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
718274001192	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
718274001193	microcin B17 transporter; Reviewed; Region: PRK11098
718274001194	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
718274001195	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
718274001196	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
718274001197	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
718274001198	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
718274001199	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
718274001200	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
718274001201	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
718274001202	drug efflux system protein MdtG; Provisional; Region: PRK09874
718274001203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274001204	putative substrate translocation pore; other site
718274001205	anti-RssB factor; Provisional; Region: PRK10244
718274001206	hypothetical protein; Provisional; Region: PRK11505
718274001207	psiF repeat; Region: PsiF_repeat; pfam07769
718274001208	psiF repeat; Region: PsiF_repeat; pfam07769
718274001209	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
718274001210	MASE2 domain; Region: MASE2; pfam05230
718274001211	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718274001212	metal binding site [ion binding]; metal-binding site
718274001213	active site
718274001214	I-site; other site
718274001215	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
718274001216	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
718274001217	hypothetical protein; Validated; Region: PRK00124
718274001218	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
718274001219	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
718274001220	ADP binding site [chemical binding]; other site
718274001221	magnesium binding site [ion binding]; other site
718274001222	putative shikimate binding site; other site
718274001223	hypothetical protein; Provisional; Region: PRK10380
718274001224	hypothetical protein; Provisional; Region: PRK10481
718274001225	hypothetical protein; Provisional; Region: PRK10579
718274001226	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
718274001227	fructokinase; Reviewed; Region: PRK09557
718274001228	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718274001229	nucleotide binding site [chemical binding]; other site
718274001230	MFS transport protein AraJ; Provisional; Region: PRK10091
718274001231	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274001232	putative substrate translocation pore; other site
718274001233	exonuclease subunit SbcC; Provisional; Region: PRK10246
718274001234	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274001235	Walker A/P-loop; other site
718274001236	ATP binding site [chemical binding]; other site
718274001237	Q-loop/lid; other site
718274001238	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274001239	ABC transporter signature motif; other site
718274001240	Walker B; other site
718274001241	D-loop; other site
718274001242	H-loop/switch region; other site
718274001243	exonuclease subunit SbcD; Provisional; Region: PRK10966
718274001244	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
718274001245	active site
718274001246	metal binding site [ion binding]; metal-binding site
718274001247	DNA binding site [nucleotide binding]
718274001248	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
718274001249	transcriptional regulator PhoB; Provisional; Region: PRK10161
718274001250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274001251	active site
718274001252	phosphorylation site [posttranslational modification]
718274001253	intermolecular recognition site; other site
718274001254	dimerization interface [polypeptide binding]; other site
718274001255	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274001256	DNA binding site [nucleotide binding]
718274001257	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
718274001258	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
718274001259	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
718274001260	putative active site [active]
718274001261	heme pocket [chemical binding]; other site
718274001262	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274001263	dimer interface [polypeptide binding]; other site
718274001264	phosphorylation site [posttranslational modification]
718274001265	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274001266	ATP binding site [chemical binding]; other site
718274001267	Mg2+ binding site [ion binding]; other site
718274001268	G-X-G motif; other site
718274001269	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
718274001270	putative proline-specific permease; Provisional; Region: proY; PRK10580
718274001271	maltodextrin glucosidase; Provisional; Region: PRK10785
718274001272	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
718274001273	homodimer interface [polypeptide binding]; other site
718274001274	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
718274001275	active site
718274001276	homodimer interface [polypeptide binding]; other site
718274001277	catalytic site [active]
718274001278	peroxidase; Provisional; Region: PRK15000
718274001279	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
718274001280	dimer interface [polypeptide binding]; other site
718274001281	decamer (pentamer of dimers) interface [polypeptide binding]; other site
718274001282	catalytic triad [active]
718274001283	peroxidatic and resolving cysteines [active]
718274001284	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
718274001285	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
718274001286	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
718274001287	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
718274001288	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
718274001289	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
718274001290	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
718274001291	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
718274001292	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
718274001293	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
718274001294	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
718274001295	Protein export membrane protein; Region: SecD_SecF; pfam02355
718274001296	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
718274001297	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
718274001298	Predicted transcriptional regulator [Transcription]; Region: COG2378
718274001299	HTH domain; Region: HTH_11; pfam08279
718274001300	WYL domain; Region: WYL; pfam13280
718274001301	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
718274001302	active site
718274001303	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
718274001304	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
718274001305	hypothetical protein; Provisional; Region: PRK11530
718274001306	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
718274001307	ATP cone domain; Region: ATP-cone; pfam03477
718274001308	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
718274001309	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
718274001310	catalytic motif [active]
718274001311	Zn binding site [ion binding]; other site
718274001312	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
718274001313	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
718274001314	homopentamer interface [polypeptide binding]; other site
718274001315	active site
718274001316	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
718274001317	putative RNA binding site [nucleotide binding]; other site
718274001318	thiamine monophosphate kinase; Provisional; Region: PRK05731
718274001319	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
718274001320	ATP binding site [chemical binding]; other site
718274001321	dimerization interface [polypeptide binding]; other site
718274001322	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
718274001323	tetramer interfaces [polypeptide binding]; other site
718274001324	binuclear metal-binding site [ion binding]; other site
718274001325	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718274001326	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718274001327	active site
718274001328	catalytic tetrad [active]
718274001329	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
718274001330	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
718274001331	TPP-binding site; other site
718274001332	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
718274001333	PYR/PP interface [polypeptide binding]; other site
718274001334	dimer interface [polypeptide binding]; other site
718274001335	TPP binding site [chemical binding]; other site
718274001336	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
718274001337	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
718274001338	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
718274001339	substrate binding pocket [chemical binding]; other site
718274001340	chain length determination region; other site
718274001341	substrate-Mg2+ binding site; other site
718274001342	catalytic residues [active]
718274001343	aspartate-rich region 1; other site
718274001344	active site lid residues [active]
718274001345	aspartate-rich region 2; other site
718274001346	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
718274001347	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
718274001348	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
718274001349	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
718274001350	Ligand Binding Site [chemical binding]; other site
718274001351	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
718274001352	active site residue [active]
718274001353	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
718274001354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274001355	dimer interface [polypeptide binding]; other site
718274001356	conserved gate region; other site
718274001357	ABC-ATPase subunit interface; other site
718274001358	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
718274001359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274001360	dimer interface [polypeptide binding]; other site
718274001361	conserved gate region; other site
718274001362	putative PBP binding loops; other site
718274001363	ABC-ATPase subunit interface; other site
718274001364	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
718274001365	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274001366	Walker A/P-loop; other site
718274001367	ATP binding site [chemical binding]; other site
718274001368	Q-loop/lid; other site
718274001369	ABC transporter signature motif; other site
718274001370	Walker B; other site
718274001371	D-loop; other site
718274001372	H-loop/switch region; other site
718274001373	TOBE domain; Region: TOBE_2; pfam08402
718274001374	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
718274001375	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
718274001376	transcriptional regulator protein; Region: phnR; TIGR03337
718274001377	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274001378	DNA-binding site [nucleotide binding]; DNA binding site
718274001379	UTRA domain; Region: UTRA; pfam07702
718274001380	2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326
718274001381	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718274001382	catalytic residue [active]
718274001383	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
718274001384	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274001385	motif II; other site
718274001386	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
718274001387	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
718274001388	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
718274001389	conserved cys residue [active]
718274001390	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
718274001391	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
718274001392	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
718274001393	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
718274001394	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
718274001395	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274001396	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718274001397	putative substrate translocation pore; other site
718274001398	Sel1-like repeats; Region: SEL1; smart00671
718274001399	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
718274001400	Sel1 repeat; Region: Sel1; pfam08238
718274001401	Sel1-like repeats; Region: SEL1; smart00671
718274001402	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
718274001403	Sel1-like repeats; Region: SEL1; smart00671
718274001404	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
718274001405	Sel1-like repeats; Region: SEL1; smart00671
718274001406	Sel1-like repeats; Region: SEL1; smart00671
718274001407	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
718274001408	UbiA prenyltransferase family; Region: UbiA; pfam01040
718274001409	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
718274001410	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
718274001411	Subunit I/III interface [polypeptide binding]; other site
718274001412	Subunit III/IV interface [polypeptide binding]; other site
718274001413	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
718274001414	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
718274001415	D-pathway; other site
718274001416	Putative ubiquinol binding site [chemical binding]; other site
718274001417	Low-spin heme (heme b) binding site [chemical binding]; other site
718274001418	Putative water exit pathway; other site
718274001419	Binuclear center (heme o3/CuB) [ion binding]; other site
718274001420	K-pathway; other site
718274001421	Putative proton exit pathway; other site
718274001422	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
718274001423	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
718274001424	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
718274001425	muropeptide transporter; Reviewed; Region: ampG; PRK11902
718274001426	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274001427	putative substrate translocation pore; other site
718274001428	hypothetical protein; Provisional; Region: PRK11627
718274001429	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
718274001430	transcriptional regulator BolA; Provisional; Region: PRK11628
718274001431	trigger factor; Provisional; Region: tig; PRK01490
718274001432	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
718274001433	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
718274001434	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
718274001435	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
718274001436	oligomer interface [polypeptide binding]; other site
718274001437	active site residues [active]
718274001438	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
718274001439	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
718274001440	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274001441	Walker A motif; other site
718274001442	ATP binding site [chemical binding]; other site
718274001443	Walker B motif; other site
718274001444	Iron permease FTR1 family; Region: FTR1; cl00475
718274001445	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
718274001446	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
718274001447	Found in ATP-dependent protease La (LON); Region: LON; smart00464
718274001448	Found in ATP-dependent protease La (LON); Region: LON; smart00464
718274001449	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274001450	Walker A motif; other site
718274001451	ATP binding site [chemical binding]; other site
718274001452	Walker B motif; other site
718274001453	arginine finger; other site
718274001454	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
718274001455	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
718274001456	IHF dimer interface [polypeptide binding]; other site
718274001457	IHF - DNA interface [nucleotide binding]; other site
718274001458	periplasmic folding chaperone; Provisional; Region: PRK10788
718274001459	SurA N-terminal domain; Region: SurA_N_3; cl07813
718274001460	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
718274001461	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
718274001462	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
718274001463	active site
718274001464	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
718274001465	Ligand Binding Site [chemical binding]; other site
718274001466	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
718274001467	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
718274001468	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
718274001469	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
718274001470	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274001471	active site
718274001472	motif I; other site
718274001473	motif II; other site
718274001474	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
718274001475	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
718274001476	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718274001477	catalytic residue [active]
718274001478	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
718274001479	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718274001480	putative DNA binding site [nucleotide binding]; other site
718274001481	putative Zn2+ binding site [ion binding]; other site
718274001482	AsnC family; Region: AsnC_trans_reg; pfam01037
718274001483	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
718274001484	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718274001485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274001486	Walker A/P-loop; other site
718274001487	ATP binding site [chemical binding]; other site
718274001488	Q-loop/lid; other site
718274001489	ABC transporter signature motif; other site
718274001490	Walker B; other site
718274001491	D-loop; other site
718274001492	H-loop/switch region; other site
718274001493	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
718274001494	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718274001495	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274001496	Walker A/P-loop; other site
718274001497	ATP binding site [chemical binding]; other site
718274001498	Q-loop/lid; other site
718274001499	ABC transporter signature motif; other site
718274001500	Walker B; other site
718274001501	D-loop; other site
718274001502	H-loop/switch region; other site
718274001503	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
718274001504	Nitrogen regulatory protein P-II; Region: P-II; smart00938
718274001505	ammonium transporter; Provisional; Region: PRK10666
718274001506	acyl-CoA thioesterase II; Provisional; Region: PRK10526
718274001507	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
718274001508	active site
718274001509	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
718274001510	catalytic triad [active]
718274001511	dimer interface [polypeptide binding]; other site
718274001512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
718274001513	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
718274001514	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
718274001515	DNA binding site [nucleotide binding]
718274001516	active site
718274001517	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
718274001518	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
718274001519	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274001520	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
718274001521	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
718274001522	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
718274001523	maltose O-acetyltransferase; Provisional; Region: PRK10092
718274001524	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
718274001525	active site
718274001526	substrate binding site [chemical binding]; other site
718274001527	trimer interface [polypeptide binding]; other site
718274001528	CoA binding site [chemical binding]; other site
718274001529	gene expression modulator; Provisional; Region: PRK10945
718274001530	Hha toxicity attenuator; Provisional; Region: PRK10667
718274001531	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
718274001532	Protein export membrane protein; Region: SecD_SecF; cl14618
718274001533	Protein export membrane protein; Region: SecD_SecF; cl14618
718274001534	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
718274001535	HlyD family secretion protein; Region: HlyD_3; pfam13437
718274001536	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
718274001537	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274001538	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
718274001539	hypothetical protein; Provisional; Region: PRK11281
718274001540	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
718274001541	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
718274001542	Mechanosensitive ion channel; Region: MS_channel; pfam00924
718274001543	Uncharacterized conserved protein [Function unknown]; Region: COG5464
718274001544	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
718274001545	hypothetical protein; Provisional; Region: PRK11038
718274001546	primosomal replication protein N''; Provisional; Region: PRK10093
718274001547	hypothetical protein; Provisional; Region: PRK10527
718274001548	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718274001549	active site
718274001550	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
718274001551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274001552	Walker A motif; other site
718274001553	ATP binding site [chemical binding]; other site
718274001554	Walker B motif; other site
718274001555	DNA polymerase III subunit delta'; Validated; Region: PRK08485
718274001556	arginine finger; other site
718274001557	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
718274001558	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
718274001559	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
718274001560	hypothetical protein; Validated; Region: PRK00153
718274001561	recombination protein RecR; Reviewed; Region: recR; PRK00076
718274001562	RecR protein; Region: RecR; pfam02132
718274001563	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
718274001564	putative active site [active]
718274001565	putative metal-binding site [ion binding]; other site
718274001566	tetramer interface [polypeptide binding]; other site
718274001567	heat shock protein 90; Provisional; Region: PRK05218
718274001568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274001569	ATP binding site [chemical binding]; other site
718274001570	Mg2+ binding site [ion binding]; other site
718274001571	G-X-G motif; other site
718274001572	adenylate kinase; Reviewed; Region: adk; PRK00279
718274001573	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
718274001574	AMP-binding site [chemical binding]; other site
718274001575	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
718274001576	ferrochelatase; Reviewed; Region: hemH; PRK00035
718274001577	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
718274001578	C-terminal domain interface [polypeptide binding]; other site
718274001579	active site
718274001580	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
718274001581	active site
718274001582	N-terminal domain interface [polypeptide binding]; other site
718274001583	acetyl esterase; Provisional; Region: PRK10162
718274001584	inosine/guanosine kinase; Provisional; Region: PRK15074
718274001585	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718274001586	putative cation:proton antiport protein; Provisional; Region: PRK10669
718274001587	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
718274001588	TrkA-N domain; Region: TrkA_N; pfam02254
718274001589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274001590	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718274001591	putative substrate translocation pore; other site
718274001592	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
718274001593	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
718274001594	active site
718274001595	metal binding site [ion binding]; metal-binding site
718274001596	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
718274001597	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
718274001598	putative deacylase active site [active]
718274001599	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
718274001600	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
718274001601	copper exporting ATPase; Provisional; Region: copA; PRK10671
718274001602	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718274001603	metal-binding site [ion binding]
718274001604	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718274001605	metal-binding site [ion binding]
718274001606	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718274001607	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274001608	motif II; other site
718274001609	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
718274001610	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
718274001611	DNA binding residues [nucleotide binding]
718274001612	dimer interface [polypeptide binding]; other site
718274001613	copper binding site [ion binding]; other site
718274001614	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
718274001615	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
718274001616	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
718274001617	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
718274001618	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
718274001619	Walker A/P-loop; other site
718274001620	ATP binding site [chemical binding]; other site
718274001621	Q-loop/lid; other site
718274001622	ABC transporter signature motif; other site
718274001623	Walker B; other site
718274001624	D-loop; other site
718274001625	H-loop/switch region; other site
718274001626	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
718274001627	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
718274001628	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
718274001629	oxidoreductase; Provisional; Region: PRK08017
718274001630	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
718274001631	NADP binding site [chemical binding]; other site
718274001632	active site
718274001633	steroid binding site; other site
718274001634	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
718274001635	active site
718274001636	catalytic triad [active]
718274001637	oxyanion hole [active]
718274001638	switch loop; other site
718274001639	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
718274001640	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718274001641	Walker A/P-loop; other site
718274001642	ATP binding site [chemical binding]; other site
718274001643	Q-loop/lid; other site
718274001644	ABC transporter signature motif; other site
718274001645	Walker B; other site
718274001646	D-loop; other site
718274001647	H-loop/switch region; other site
718274001648	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
718274001649	FtsX-like permease family; Region: FtsX; pfam02687
718274001650	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
718274001651	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
718274001652	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
718274001653	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
718274001654	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
718274001655	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
718274001656	Walker A/P-loop; other site
718274001657	ATP binding site [chemical binding]; other site
718274001658	Q-loop/lid; other site
718274001659	ABC transporter signature motif; other site
718274001660	Walker B; other site
718274001661	D-loop; other site
718274001662	H-loop/switch region; other site
718274001663	NIL domain; Region: NIL; pfam09383
718274001664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274001665	dimer interface [polypeptide binding]; other site
718274001666	conserved gate region; other site
718274001667	ABC-ATPase subunit interface; other site
718274001668	Predicted ATPase [General function prediction only]; Region: COG2603
718274001669	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
718274001670	active site residue [active]
718274001671	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
718274001672	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274001673	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718274001674	dimerization interface [polypeptide binding]; other site
718274001675	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
718274001676	ureidoglycolate hydrolase; Provisional; Region: PRK03606
718274001677	DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163
718274001678	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
718274001679	Bacterial transcriptional regulator; Region: IclR; pfam01614
718274001680	glyoxylate carboligase; Provisional; Region: PRK11269
718274001681	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
718274001682	PYR/PP interface [polypeptide binding]; other site
718274001683	dimer interface [polypeptide binding]; other site
718274001684	TPP binding site [chemical binding]; other site
718274001685	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
718274001686	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
718274001687	TPP-binding site [chemical binding]; other site
718274001688	hydroxypyruvate isomerase; Provisional; Region: PRK09997
718274001689	tartronate semialdehyde reductase; Provisional; Region: PRK15059
718274001690	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
718274001691	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274001692	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718274001693	putative substrate translocation pore; other site
718274001694	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
718274001695	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
718274001696	Na binding site [ion binding]; other site
718274001697	putative substrate binding site [chemical binding]; other site
718274001698	allantoinase; Provisional; Region: PRK08044
718274001699	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
718274001700	active site
718274001701	putative uracil/xanthine transporter; Provisional; Region: PRK11412
718274001702	glycerate kinase II; Provisional; Region: PRK09932
718274001703	Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257
718274001704	Mif2/CENP-C like; Region: Mif2; pfam11699
718274001705	Cupin domain; Region: Cupin_2; pfam07883
718274001706	allantoate amidohydrolase; Region: AllC; TIGR03176
718274001707	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
718274001708	active site
718274001709	metal binding site [ion binding]; metal-binding site
718274001710	dimer interface [polypeptide binding]; other site
718274001711	ureidoglycolate dehydrogenase; Provisional; Region: PRK15025
718274001712	membrane protein FdrA; Validated; Region: PRK06091
718274001713	CoA binding domain; Region: CoA_binding; pfam02629
718274001714	CoA-ligase; Region: Ligase_CoA; pfam00549
718274001715	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
718274001716	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
718274001717	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
718274001718	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
718274001719	putative substrate binding site [chemical binding]; other site
718274001720	nucleotide binding site [chemical binding]; other site
718274001721	nucleotide binding site [chemical binding]; other site
718274001722	homodimer interface [polypeptide binding]; other site
718274001723	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
718274001724	ATP-grasp domain; Region: ATP-grasp; pfam02222
718274001725	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
718274001726	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
718274001727	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
718274001728	putative active site [active]
718274001729	putative metal binding site [ion binding]; other site
718274001730	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
718274001731	substrate binding site [chemical binding]; other site
718274001732	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
718274001733	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
718274001734	active site
718274001735	HIGH motif; other site
718274001736	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
718274001737	KMSKS motif; other site
718274001738	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
718274001739	tRNA binding surface [nucleotide binding]; other site
718274001740	anticodon binding site; other site
718274001741	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
718274001742	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
718274001743	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
718274001744	ribosome-associated protein; Provisional; Region: PRK11507
718274001745	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
718274001746	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
718274001747	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
718274001748	homodimer interface [polypeptide binding]; other site
718274001749	NADP binding site [chemical binding]; other site
718274001750	substrate binding site [chemical binding]; other site
718274001751	type-1 fimbrial protein subunit A; Provisional; Region: PRK15194
718274001752	fimbrial protein FimI; Provisional; Region: PRK15200
718274001753	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
718274001754	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274001755	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274001756	outer membrane usher protein FimD; Provisional; Region: PRK15198
718274001757	PapC N-terminal domain; Region: PapC_N; pfam13954
718274001758	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
718274001759	PapC C-terminal domain; Region: PapC_C; pfam13953
718274001760	fimbrial-like adhesin; Provisional; Region: fimH; PRK15199
718274001761	fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934
718274001762	transcriptional regulator FimZ; Provisional; Region: PRK09935
718274001763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274001764	active site
718274001765	phosphorylation site [posttranslational modification]
718274001766	intermolecular recognition site; other site
718274001767	dimerization interface [polypeptide binding]; other site
718274001768	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274001769	DNA binding residues [nucleotide binding]
718274001770	dimerization interface [polypeptide binding]; other site
718274001771	fimbriae regulatory protein FimW; Provisional; Region: PRK15201
718274001772	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274001773	DNA binding residues [nucleotide binding]
718274001774	dimerization interface [polypeptide binding]; other site
718274001775	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
718274001776	Transposase; Region: HTH_Tnp_1; pfam01527
718274001777	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
718274001778	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
718274001779	Ligand binding site; other site
718274001780	Putative Catalytic site; other site
718274001781	DXD motif; other site
718274001782	Predicted membrane protein [Function unknown]; Region: COG2246
718274001783	GtrA-like protein; Region: GtrA; pfam04138
718274001784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274001785	ATP binding site [chemical binding]; other site
718274001786	Mg2+ binding site [ion binding]; other site
718274001787	G-X-G motif; other site
718274001788	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
718274001789	Cupin; Region: Cupin_6; pfam12852
718274001790	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718274001791	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274001792	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274001793	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
718274001794	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274001795	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
718274001796	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
718274001797	Predicted membrane protein [Function unknown]; Region: COG3059
718274001798	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
718274001799	phenylalanine transporter; Provisional; Region: PRK10249
718274001800	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
718274001801	Mechanosensitive ion channel; Region: MS_channel; pfam00924
718274001802	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
718274001803	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
718274001804	active site
718274001805	oxyanion hole [active]
718274001806	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
718274001807	catalytic triad [active]
718274001808	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
718274001809	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
718274001810	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274001811	ATP binding site [chemical binding]; other site
718274001812	Walker B motif; other site
718274001813	arginine finger; other site
718274001814	Transcriptional antiterminator [Transcription]; Region: COG3933
718274001815	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
718274001816	active pocket/dimerization site; other site
718274001817	active site
718274001818	phosphorylation site [posttranslational modification]
718274001819	PRD domain; Region: PRD; pfam00874
718274001820	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
718274001821	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
718274001822	putative active site [active]
718274001823	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
718274001824	dimer interface [polypeptide binding]; other site
718274001825	active site
718274001826	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
718274001827	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
718274001828	dimer interface [polypeptide binding]; other site
718274001829	active site
718274001830	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
718274001831	dimer interface [polypeptide binding]; other site
718274001832	active site
718274001833	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
718274001834	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
718274001835	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
718274001836	active site
718274001837	phosphorylation site [posttranslational modification]
718274001838	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
718274001839	active pocket/dimerization site; other site
718274001840	active site
718274001841	phosphorylation site [posttranslational modification]
718274001842	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
718274001843	dimer interface [polypeptide binding]; other site
718274001844	FMN binding site [chemical binding]; other site
718274001845	hypothetical protein; Provisional; Region: PRK10250
718274001846	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
718274001847	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274001848	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
718274001849	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274001850	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
718274001851	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
718274001852	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
718274001853	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
718274001854	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
718274001855	outer membrane receptor FepA; Provisional; Region: PRK13524
718274001856	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
718274001857	N-terminal plug; other site
718274001858	ligand-binding site [chemical binding]; other site
718274001859	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
718274001860	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
718274001861	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
718274001862	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
718274001863	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
718274001864	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
718274001865	acyl-activating enzyme (AAE) consensus motif; other site
718274001866	AMP binding site [chemical binding]; other site
718274001867	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
718274001868	LPS O-antigen length regulator; Provisional; Region: PRK10381
718274001869	Chain length determinant protein; Region: Wzz; pfam02706
718274001870	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
718274001871	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
718274001872	Walker A/P-loop; other site
718274001873	ATP binding site [chemical binding]; other site
718274001874	Q-loop/lid; other site
718274001875	ABC transporter signature motif; other site
718274001876	Walker B; other site
718274001877	D-loop; other site
718274001878	H-loop/switch region; other site
718274001879	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
718274001880	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718274001881	ABC-ATPase subunit  interface; other site
718274001882	dimer interface [polypeptide binding]; other site
718274001883	putative PBP binding regions; other site
718274001884	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
718274001885	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718274001886	ABC-ATPase subunit  interface; other site
718274001887	dimer interface [polypeptide binding]; other site
718274001888	putative PBP binding regions; other site
718274001889	enterobactin exporter EntS; Provisional; Region: PRK10489
718274001890	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274001891	putative substrate translocation pore; other site
718274001892	ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592
718274001893	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
718274001894	siderophore binding site; other site
718274001895	isochorismate synthase EntC; Provisional; Region: PRK15016
718274001896	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
718274001897	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
718274001898	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
718274001899	acyl-activating enzyme (AAE) consensus motif; other site
718274001900	active site
718274001901	AMP binding site [chemical binding]; other site
718274001902	substrate binding site [chemical binding]; other site
718274001903	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
718274001904	hydrophobic substrate binding pocket; other site
718274001905	Isochorismatase family; Region: Isochorismatase; pfam00857
718274001906	active site
718274001907	conserved cis-peptide bond; other site
718274001908	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
718274001909	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
718274001910	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
718274001911	putative NAD(P) binding site [chemical binding]; other site
718274001912	active site
718274001913	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
718274001914	CoenzymeA binding site [chemical binding]; other site
718274001915	subunit interaction site [polypeptide binding]; other site
718274001916	PHB binding site; other site
718274001917	carbon starvation protein A; Provisional; Region: PRK15015
718274001918	Carbon starvation protein CstA; Region: CstA; pfam02554
718274001919	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
718274001920	Uncharacterized small protein [Function unknown]; Region: COG2879
718274001921	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
718274001922	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
718274001923	putative active site [active]
718274001924	metal binding site [ion binding]; metal-binding site
718274001925	methionine aminotransferase; Validated; Region: PRK09082
718274001926	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718274001927	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274001928	homodimer interface [polypeptide binding]; other site
718274001929	catalytic residue [active]
718274001930	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
718274001931	ParB-like nuclease domain; Region: ParBc; pfam02195
718274001932	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
718274001933	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
718274001934	Active Sites [active]
718274001935	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
718274001936	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
718274001937	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274001938	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718274001939	dimerization interface [polypeptide binding]; other site
718274001940	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
718274001941	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
718274001942	dimerization domain [polypeptide binding]; other site
718274001943	dimer interface [polypeptide binding]; other site
718274001944	catalytic residues [active]
718274001945	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
718274001946	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
718274001947	dimer interface [polypeptide binding]; other site
718274001948	decamer (pentamer of dimers) interface [polypeptide binding]; other site
718274001949	catalytic triad [active]
718274001950	peroxidatic and resolving cysteines [active]
718274001951	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
718274001952	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
718274001953	catalytic residue [active]
718274001954	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
718274001955	catalytic residues [active]
718274001956	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718274001957	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274001958	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
718274001959	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
718274001960	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
718274001961	putative [4Fe-4S] binding site [ion binding]; other site
718274001962	putative molybdopterin cofactor binding site [chemical binding]; other site
718274001963	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
718274001964	molybdopterin cofactor binding site; other site
718274001965	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
718274001966	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
718274001967	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
718274001968	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
718274001969	Ligand Binding Site [chemical binding]; other site
718274001970	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
718274001971	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
718274001972	NAD binding site [chemical binding]; other site
718274001973	catalytic Zn binding site [ion binding]; other site
718274001974	structural Zn binding site [ion binding]; other site
718274001975	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
718274001976	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
718274001977	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
718274001978	B1 nucleotide binding pocket [chemical binding]; other site
718274001979	B2 nucleotide binding pocket [chemical binding]; other site
718274001980	CAS motifs; other site
718274001981	active site
718274001982	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
718274001983	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
718274001984	transmembrane helices; other site
718274001985	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
718274001986	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
718274001987	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
718274001988	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
718274001989	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
718274001990	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
718274001991	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
718274001992	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
718274001993	putative active site [active]
718274001994	(T/H)XGH motif; other site
718274001995	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
718274001996	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
718274001997	putative active site [active]
718274001998	heme pocket [chemical binding]; other site
718274001999	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274002000	ATP binding site [chemical binding]; other site
718274002001	Mg2+ binding site [ion binding]; other site
718274002002	G-X-G motif; other site
718274002003	two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046
718274002004	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274002005	active site
718274002006	phosphorylation site [posttranslational modification]
718274002007	intermolecular recognition site; other site
718274002008	dimerization interface [polypeptide binding]; other site
718274002009	Transcriptional regulator; Region: CitT; pfam12431
718274002010	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
718274002011	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
718274002012	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
718274002013	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
718274002014	DNA-binding site [nucleotide binding]; DNA binding site
718274002015	RNA-binding motif; other site
718274002016	chromosome condensation membrane protein; Provisional; Region: PRK14196
718274002017	Predicted amidohydrolase [General function prediction only]; Region: COG0388
718274002018	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
718274002019	putative active site [active]
718274002020	catalytic triad [active]
718274002021	putative dimer interface [polypeptide binding]; other site
718274002022	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
718274002023	lipoyl synthase; Provisional; Region: PRK05481
718274002024	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274002025	FeS/SAM binding site; other site
718274002026	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
718274002027	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274002028	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
718274002029	substrate binding pocket [chemical binding]; other site
718274002030	dimerization interface [polypeptide binding]; other site
718274002031	lipoate-protein ligase B; Provisional; Region: PRK14342
718274002032	hypothetical protein; Provisional; Region: PRK04998
718274002033	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
718274002034	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
718274002035	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
718274002036	rare lipoprotein A; Provisional; Region: PRK10672
718274002037	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
718274002038	Sporulation related domain; Region: SPOR; pfam05036
718274002039	cell wall shape-determining protein; Provisional; Region: PRK10794
718274002040	penicillin-binding protein 2; Provisional; Region: PRK10795
718274002041	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
718274002042	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
718274002043	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
718274002044	ribosome-associated protein; Provisional; Region: PRK11538
718274002045	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718274002046	catalytic core [active]
718274002047	threonine-phosphate decarboxylase; Provisional; Region: PRK08056
718274002048	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718274002049	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274002050	homodimer interface [polypeptide binding]; other site
718274002051	catalytic residue [active]
718274002052	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
718274002053	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
718274002054	active site
718274002055	(T/H)XGH motif; other site
718274002056	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
718274002057	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
718274002058	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
718274002059	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
718274002060	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
718274002061	HIGH motif; other site
718274002062	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
718274002063	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718274002064	active site
718274002065	KMSKS motif; other site
718274002066	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
718274002067	tRNA binding surface [nucleotide binding]; other site
718274002068	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
718274002069	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
718274002070	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
718274002071	Propionate catabolism activator; Region: PrpR_N; pfam06506
718274002072	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
718274002073	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274002074	Walker A motif; other site
718274002075	ATP binding site [chemical binding]; other site
718274002076	Walker B motif; other site
718274002077	arginine finger; other site
718274002078	hypothetical protein; Provisional; Region: PRK11032
718274002079	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
718274002080	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
718274002081	Sel1-like repeats; Region: SEL1; smart00671
718274002082	Sel1-like repeats; Region: SEL1; smart00671
718274002083	Sel1-like repeats; Region: SEL1; smart00671
718274002084	Sel1-like repeats; Region: SEL1; smart00671
718274002085	Sel1-like repeats; Region: SEL1; smart00671
718274002086	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
718274002087	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
718274002088	HSP70 interaction site [polypeptide binding]; other site
718274002089	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
718274002090	DnaJ domain; Region: DnaJ; pfam00226
718274002091	HSP70 interaction site [polypeptide binding]; other site
718274002092	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
718274002093	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
718274002094	nucleotide binding site [chemical binding]; other site
718274002095	putative NEF/HSP70 interaction site [polypeptide binding]; other site
718274002096	SBD interface [polypeptide binding]; other site
718274002097	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
718274002098	active site
718274002099	tetramer interface [polypeptide binding]; other site
718274002100	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
718274002101	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
718274002102	Walker A/P-loop; other site
718274002103	ATP binding site [chemical binding]; other site
718274002104	Q-loop/lid; other site
718274002105	ABC transporter signature motif; other site
718274002106	Walker B; other site
718274002107	D-loop; other site
718274002108	H-loop/switch region; other site
718274002109	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718274002110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274002111	dimer interface [polypeptide binding]; other site
718274002112	conserved gate region; other site
718274002113	putative PBP binding loops; other site
718274002114	ABC-ATPase subunit interface; other site
718274002115	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718274002116	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274002117	dimer interface [polypeptide binding]; other site
718274002118	conserved gate region; other site
718274002119	putative PBP binding loops; other site
718274002120	ABC-ATPase subunit interface; other site
718274002121	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
718274002122	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274002123	substrate binding pocket [chemical binding]; other site
718274002124	membrane-bound complex binding site; other site
718274002125	hinge residues; other site
718274002126	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
718274002127	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
718274002128	putative active site [active]
718274002129	catalytic triad [active]
718274002130	putative dimer interface [polypeptide binding]; other site
718274002131	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
718274002132	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
718274002133	Transporter associated domain; Region: CorC_HlyC; smart01091
718274002134	metal-binding heat shock protein; Provisional; Region: PRK00016
718274002135	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
718274002136	PhoH-like protein; Region: PhoH; pfam02562
718274002137	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
718274002138	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
718274002139	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274002140	FeS/SAM binding site; other site
718274002141	TRAM domain; Region: TRAM; pfam01938
718274002142	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
718274002143	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
718274002144	asparagine synthetase B; Provisional; Region: asnB; PRK09431
718274002145	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
718274002146	active site
718274002147	dimer interface [polypeptide binding]; other site
718274002148	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
718274002149	Ligand Binding Site [chemical binding]; other site
718274002150	Molecular Tunnel; other site
718274002151	UMP phosphatase; Provisional; Region: PRK10444
718274002152	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274002153	active site
718274002154	motif I; other site
718274002155	motif II; other site
718274002156	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274002157	MarR family; Region: MarR; pfam01047
718274002158	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
718274002159	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718274002160	nucleotide binding site [chemical binding]; other site
718274002161	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
718274002162	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
718274002163	active site
718274002164	dimer interface [polypeptide binding]; other site
718274002165	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
718274002166	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
718274002167	active site
718274002168	trimer interface [polypeptide binding]; other site
718274002169	allosteric site; other site
718274002170	active site lid [active]
718274002171	hexamer (dimer of trimers) interface [polypeptide binding]; other site
718274002172	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
718274002173	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
718274002174	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
718274002175	active site turn [active]
718274002176	phosphorylation site [posttranslational modification]
718274002177	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
718274002178	HPr interaction site; other site
718274002179	glycerol kinase (GK) interaction site [polypeptide binding]; other site
718274002180	active site
718274002181	phosphorylation site [posttranslational modification]
718274002182	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
718274002183	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
718274002184	active site
718274002185	HIGH motif; other site
718274002186	nucleotide binding site [chemical binding]; other site
718274002187	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
718274002188	KMSKS motif; other site
718274002189	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
718274002190	outer membrane porin, OprD family; Region: OprD; pfam03573
718274002191	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
718274002192	YbfN-like lipoprotein; Region: YbfN; pfam13982
718274002193	citrate-proton symporter; Provisional; Region: PRK15075
718274002194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274002195	putative substrate translocation pore; other site
718274002196	tricarballylate utilization protein B; Provisional; Region: PRK15033
718274002197	tricarballylate dehydrogenase; Validated; Region: PRK08274
718274002198	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718274002199	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274002200	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274002201	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
718274002202	putative dimerization interface [polypeptide binding]; other site
718274002203	ferric uptake regulator; Provisional; Region: fur; PRK09462
718274002204	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
718274002205	metal binding site 2 [ion binding]; metal-binding site
718274002206	putative DNA binding helix; other site
718274002207	metal binding site 1 [ion binding]; metal-binding site
718274002208	dimer interface [polypeptide binding]; other site
718274002209	structural Zn2+ binding site [ion binding]; other site
718274002210	flavodoxin FldA; Validated; Region: PRK09267
718274002211	LexA regulated protein; Provisional; Region: PRK11675
718274002212	acyl-CoA esterase; Provisional; Region: PRK10673
718274002213	PGAP1-like protein; Region: PGAP1; pfam07819
718274002214	replication initiation regulator SeqA; Provisional; Region: PRK11187
718274002215	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
718274002216	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
718274002217	active site
718274002218	substrate binding site [chemical binding]; other site
718274002219	metal binding site [ion binding]; metal-binding site
718274002220	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
718274002221	putrescine transporter; Provisional; Region: potE; PRK10655
718274002222	ornithine decarboxylase; Provisional; Region: PRK13578
718274002223	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
718274002224	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
718274002225	homodimer interface [polypeptide binding]; other site
718274002226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274002227	catalytic residue [active]
718274002228	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
718274002229	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
718274002230	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274002231	active site
718274002232	phosphorylation site [posttranslational modification]
718274002233	intermolecular recognition site; other site
718274002234	dimerization interface [polypeptide binding]; other site
718274002235	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274002236	DNA binding site [nucleotide binding]
718274002237	sensor protein KdpD; Provisional; Region: PRK10490
718274002238	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
718274002239	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
718274002240	Ligand Binding Site [chemical binding]; other site
718274002241	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
718274002242	GAF domain; Region: GAF_3; pfam13492
718274002243	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274002244	dimer interface [polypeptide binding]; other site
718274002245	phosphorylation site [posttranslational modification]
718274002246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274002247	ATP binding site [chemical binding]; other site
718274002248	Mg2+ binding site [ion binding]; other site
718274002249	G-X-G motif; other site
718274002250	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
718274002251	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
718274002252	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718274002253	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
718274002254	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
718274002255	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
718274002256	DNA photolyase; Region: DNA_photolyase; pfam00875
718274002257	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
718274002258	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274002259	putative substrate translocation pore; other site
718274002260	POT family; Region: PTR2; pfam00854
718274002261	Uncharacterized conserved protein [Function unknown]; Region: COG0327
718274002262	metal-binding protein; Provisional; Region: PRK10799
718274002263	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
718274002264	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
718274002265	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
718274002266	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
718274002267	putative active site [active]
718274002268	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274002269	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274002270	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274002271	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
718274002272	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718274002273	active site
718274002274	DNA binding site [nucleotide binding]
718274002275	Int/Topo IB signature motif; other site
718274002276	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
718274002277	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
718274002278	UDP-galactopyranose mutase; Region: GLF; pfam03275
718274002279	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
718274002280	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718274002281	active site
718274002282	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
718274002283	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718274002284	putative ADP-binding pocket [chemical binding]; other site
718274002285	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
718274002286	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
718274002287	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
718274002288	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
718274002289	Walker A/P-loop; other site
718274002290	ATP binding site [chemical binding]; other site
718274002291	Q-loop/lid; other site
718274002292	ABC transporter signature motif; other site
718274002293	Walker B; other site
718274002294	D-loop; other site
718274002295	H-loop/switch region; other site
718274002296	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
718274002297	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718274002298	active site
718274002299	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718274002300	active site
718274002301	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
718274002302	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
718274002303	endonuclease VIII; Provisional; Region: PRK10445
718274002304	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
718274002305	DNA binding site [nucleotide binding]
718274002306	catalytic residue [active]
718274002307	putative catalytic residues [active]
718274002308	H2TH interface [polypeptide binding]; other site
718274002309	intercalation triad [nucleotide binding]; other site
718274002310	substrate specificity determining residue; other site
718274002311	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
718274002312	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
718274002313	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
718274002314	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
718274002315	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
718274002316	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
718274002317	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
718274002318	dimer interface [polypeptide binding]; other site
718274002319	active site
718274002320	citrylCoA binding site [chemical binding]; other site
718274002321	NADH binding [chemical binding]; other site
718274002322	cationic pore residues; other site
718274002323	oxalacetate/citrate binding site [chemical binding]; other site
718274002324	coenzyme A binding site [chemical binding]; other site
718274002325	catalytic triad [active]
718274002326	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
718274002327	Iron-sulfur protein interface; other site
718274002328	proximal quinone binding site [chemical binding]; other site
718274002329	SdhD (CybS) interface [polypeptide binding]; other site
718274002330	proximal heme binding site [chemical binding]; other site
718274002331	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
718274002332	SdhC subunit interface [polypeptide binding]; other site
718274002333	proximal heme binding site [chemical binding]; other site
718274002334	cardiolipin binding site; other site
718274002335	Iron-sulfur protein interface; other site
718274002336	proximal quinone binding site [chemical binding]; other site
718274002337	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
718274002338	L-aspartate oxidase; Provisional; Region: PRK06175
718274002339	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
718274002340	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
718274002341	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
718274002342	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
718274002343	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
718274002344	TPP-binding site [chemical binding]; other site
718274002345	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
718274002346	dimer interface [polypeptide binding]; other site
718274002347	PYR/PP interface [polypeptide binding]; other site
718274002348	TPP binding site [chemical binding]; other site
718274002349	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
718274002350	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
718274002351	E3 interaction surface; other site
718274002352	lipoyl attachment site [posttranslational modification]; other site
718274002353	e3 binding domain; Region: E3_binding; pfam02817
718274002354	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
718274002355	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
718274002356	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
718274002357	CoA-ligase; Region: Ligase_CoA; pfam00549
718274002358	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
718274002359	CoA binding domain; Region: CoA_binding; smart00881
718274002360	CoA-ligase; Region: Ligase_CoA; pfam00549
718274002361	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
718274002362	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
718274002363	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
718274002364	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
718274002365	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
718274002366	hypothetical protein; Provisional; Region: PRK10588
718274002367	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
718274002368	active site
718274002369	colicin uptake protein TolQ; Provisional; Region: PRK10801
718274002370	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
718274002371	colicin uptake protein TolR; Provisional; Region: PRK11024
718274002372	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
718274002373	TolA C-terminal; Region: TolA; pfam06519
718274002374	translocation protein TolB; Provisional; Region: tolB; PRK03629
718274002375	TolB amino-terminal domain; Region: TolB_N; pfam04052
718274002376	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
718274002377	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
718274002378	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
718274002379	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
718274002380	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
718274002381	ligand binding site [chemical binding]; other site
718274002382	tol-pal system protein YbgF; Provisional; Region: PRK10803
718274002383	Tetratricopeptide repeat; Region: TPR_6; pfam13174
718274002384	Tetratricopeptide repeat; Region: TPR_6; pfam13174
718274002385	quinolinate synthetase; Provisional; Region: PRK09375
718274002386	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
718274002387	zinc transporter ZitB; Provisional; Region: PRK03557
718274002388	YbgS-like protein; Region: YbgS; pfam13985
718274002389	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
718274002390	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
718274002391	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
718274002392	fumarate hydratase; Provisional; Region: PRK06246
718274002393	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274002394	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274002395	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718274002396	dimerization interface [polypeptide binding]; other site
718274002397	cell density-dependent motility repressor; Provisional; Region: PRK10082
718274002398	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274002399	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718274002400	dimerization interface [polypeptide binding]; other site
718274002401	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
718274002402	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
718274002403	transmembrane helices; other site
718274002404	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
718274002405	oxaloacetate decarboxylase; Provisional; Region: PRK14040
718274002406	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
718274002407	active site
718274002408	catalytic residues [active]
718274002409	metal binding site [ion binding]; metal-binding site
718274002410	homodimer binding site [polypeptide binding]; other site
718274002411	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
718274002412	carboxyltransferase (CT) interaction site; other site
718274002413	biotinylation site [posttranslational modification]; other site
718274002414	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
718274002415	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
718274002416	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
718274002417	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718274002418	dimer interface [polypeptide binding]; other site
718274002419	putative PBP binding regions; other site
718274002420	ABC-ATPase subunit  interface; other site
718274002421	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
718274002422	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
718274002423	Walker A/P-loop; other site
718274002424	ATP binding site [chemical binding]; other site
718274002425	Q-loop/lid; other site
718274002426	ABC transporter signature motif; other site
718274002427	Walker B; other site
718274002428	D-loop; other site
718274002429	H-loop/switch region; other site
718274002430	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718274002431	catalytic core [active]
718274002432	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718274002433	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
718274002434	active site
718274002435	catalytic residues [active]
718274002436	galactokinase; Provisional; Region: PRK05101
718274002437	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
718274002438	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
718274002439	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
718274002440	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
718274002441	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
718274002442	dimer interface [polypeptide binding]; other site
718274002443	active site
718274002444	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
718274002445	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
718274002446	NAD binding site [chemical binding]; other site
718274002447	homodimer interface [polypeptide binding]; other site
718274002448	active site
718274002449	substrate binding site [chemical binding]; other site
718274002450	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714
718274002451	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
718274002452	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274002453	Walker A/P-loop; other site
718274002454	ATP binding site [chemical binding]; other site
718274002455	Q-loop/lid; other site
718274002456	ABC transporter signature motif; other site
718274002457	Walker B; other site
718274002458	D-loop; other site
718274002459	H-loop/switch region; other site
718274002460	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274002461	Walker A/P-loop; other site
718274002462	ATP binding site [chemical binding]; other site
718274002463	Q-loop/lid; other site
718274002464	ABC transporter signature motif; other site
718274002465	Walker B; other site
718274002466	D-loop; other site
718274002467	H-loop/switch region; other site
718274002468	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
718274002469	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
718274002470	molybdenum-pterin binding domain; Region: Mop; TIGR00638
718274002471	TOBE domain; Region: TOBE; pfam03459
718274002472	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
718274002473	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
718274002474	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274002475	substrate binding pocket [chemical binding]; other site
718274002476	membrane-bound complex binding site; other site
718274002477	hinge residues; other site
718274002478	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
718274002479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274002480	dimer interface [polypeptide binding]; other site
718274002481	conserved gate region; other site
718274002482	putative PBP binding loops; other site
718274002483	ABC-ATPase subunit interface; other site
718274002484	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
718274002485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274002486	Walker A/P-loop; other site
718274002487	ATP binding site [chemical binding]; other site
718274002488	Q-loop/lid; other site
718274002489	ABC transporter signature motif; other site
718274002490	Walker B; other site
718274002491	D-loop; other site
718274002492	H-loop/switch region; other site
718274002493	molybdenum-pterin binding domain; Region: Mop; TIGR00638
718274002494	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
718274002495	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274002496	active site
718274002497	motif I; other site
718274002498	motif II; other site
718274002499	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274002500	6-phosphogluconolactonase; Provisional; Region: PRK11028
718274002501	acyl-CoA thioesterase; Provisional; Region: PRK10531
718274002502	putative pectinesterase; Region: PLN02432; cl01911
718274002503	imidazolonepropionase; Validated; Region: PRK09356
718274002504	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
718274002505	active site
718274002506	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
718274002507	putative active site [active]
718274002508	putative metal binding site [ion binding]; other site
718274002509	histidine utilization repressor; Provisional; Region: PRK14999
718274002510	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274002511	DNA-binding site [nucleotide binding]; DNA binding site
718274002512	UTRA domain; Region: UTRA; pfam07702
718274002513	potential frameshift: common BLAST hit: gi|224582603|ref|YP_002636401.1| urocanate hydratase
718274002514	urocanate hydratase; Provisional; Region: PRK05414
718274002515	urocanate hydratase; Provisional; Region: PRK05414
718274002516	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
718274002517	active sites [active]
718274002518	tetramer interface [polypeptide binding]; other site
718274002519	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
718274002520	substrate binding site [chemical binding]; other site
718274002521	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
718274002522	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
718274002523	inhibitor-cofactor binding pocket; inhibition site
718274002524	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274002525	catalytic residue [active]
718274002526	biotin synthase; Provisional; Region: PRK15108
718274002527	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274002528	FeS/SAM binding site; other site
718274002529	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
718274002530	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
718274002531	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
718274002532	substrate-cofactor binding pocket; other site
718274002533	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274002534	catalytic residue [active]
718274002535	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
718274002536	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274002537	S-adenosylmethionine binding site [chemical binding]; other site
718274002538	AAA domain; Region: AAA_26; pfam13500
718274002539	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
718274002540	excinuclease ABC subunit B; Provisional; Region: PRK05298
718274002541	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718274002542	ATP binding site [chemical binding]; other site
718274002543	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274002544	nucleotide binding region [chemical binding]; other site
718274002545	ATP-binding site [chemical binding]; other site
718274002546	Ultra-violet resistance protein B; Region: UvrB; pfam12344
718274002547	UvrB/uvrC motif; Region: UVR; pfam02151
718274002548	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
718274002549	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
718274002550	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
718274002551	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
718274002552	Leucine-rich repeats; other site
718274002553	Substrate binding site [chemical binding]; other site
718274002554	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
718274002555	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
718274002556	putative substrate binding pocket [chemical binding]; other site
718274002557	dimer interface [polypeptide binding]; other site
718274002558	phosphate binding site [ion binding]; other site
718274002559	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
718274002560	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274002561	FeS/SAM binding site; other site
718274002562	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
718274002563	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
718274002564	MPT binding site; other site
718274002565	trimer interface [polypeptide binding]; other site
718274002566	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
718274002567	trimer interface [polypeptide binding]; other site
718274002568	dimer interface [polypeptide binding]; other site
718274002569	putative active site [active]
718274002570	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
718274002571	MoaE interaction surface [polypeptide binding]; other site
718274002572	MoeB interaction surface [polypeptide binding]; other site
718274002573	thiocarboxylated glycine; other site
718274002574	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
718274002575	MoaE homodimer interface [polypeptide binding]; other site
718274002576	MoaD interaction [polypeptide binding]; other site
718274002577	active site residues [active]
718274002578	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
718274002579	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
718274002580	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
718274002581	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
718274002582	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
718274002583	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274002584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274002585	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274002586	Predicted integral membrane protein [Function unknown]; Region: COG0392
718274002587	cardiolipin synthase 2; Provisional; Region: PRK11263
718274002588	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
718274002589	putative active site [active]
718274002590	catalytic site [active]
718274002591	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
718274002592	putative active site [active]
718274002593	catalytic site [active]
718274002594	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
718274002595	putative catalytic site [active]
718274002596	putative metal binding site [ion binding]; other site
718274002597	putative phosphate binding site [ion binding]; other site
718274002598	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
718274002599	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
718274002600	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
718274002601	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
718274002602	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
718274002603	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
718274002604	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
718274002605	Walker A/P-loop; other site
718274002606	ATP binding site [chemical binding]; other site
718274002607	Q-loop/lid; other site
718274002608	ABC transporter signature motif; other site
718274002609	Walker B; other site
718274002610	D-loop; other site
718274002611	H-loop/switch region; other site
718274002612	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
718274002613	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
718274002614	Walker A/P-loop; other site
718274002615	ATP binding site [chemical binding]; other site
718274002616	Q-loop/lid; other site
718274002617	ABC transporter signature motif; other site
718274002618	Walker B; other site
718274002619	D-loop; other site
718274002620	H-loop/switch region; other site
718274002621	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
718274002622	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
718274002623	HlyD family secretion protein; Region: HlyD_3; pfam13437
718274002624	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
718274002625	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274002626	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
718274002627	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
718274002628	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
718274002629	ATP binding site [chemical binding]; other site
718274002630	Mg++ binding site [ion binding]; other site
718274002631	motif III; other site
718274002632	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274002633	nucleotide binding region [chemical binding]; other site
718274002634	ATP-binding site [chemical binding]; other site
718274002635	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
718274002636	DEAD_2; Region: DEAD_2; pfam06733
718274002637	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
718274002638	glycosyl transferase family protein; Provisional; Region: PRK08136
718274002639	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
718274002640	hypothetical protein; Provisional; Region: PRK10259
718274002641	hypothetical protein; Provisional; Region: PRK11019
718274002642	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
718274002643	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
718274002644	putative mechanosensitive channel protein; Provisional; Region: PRK11465
718274002645	Mechanosensitive ion channel; Region: MS_channel; pfam00924
718274002646	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
718274002647	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
718274002648	Walker A/P-loop; other site
718274002649	ATP binding site [chemical binding]; other site
718274002650	Q-loop/lid; other site
718274002651	ABC transporter signature motif; other site
718274002652	Walker B; other site
718274002653	D-loop; other site
718274002654	H-loop/switch region; other site
718274002655	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718274002656	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274002657	dimer interface [polypeptide binding]; other site
718274002658	conserved gate region; other site
718274002659	putative PBP binding loops; other site
718274002660	ABC-ATPase subunit interface; other site
718274002661	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
718274002662	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274002663	substrate binding pocket [chemical binding]; other site
718274002664	membrane-bound complex binding site; other site
718274002665	hinge residues; other site
718274002666	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
718274002667	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
718274002668	dimerization interface [polypeptide binding]; other site
718274002669	DPS ferroxidase diiron center [ion binding]; other site
718274002670	ion pore; other site
718274002671	threonine and homoserine efflux system; Provisional; Region: PRK10532
718274002672	EamA-like transporter family; Region: EamA; pfam00892
718274002673	outer membrane protein X; Provisional; Region: ompX; PRK09408
718274002674	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
718274002675	Sulfatase; Region: Sulfatase; pfam00884
718274002676	manganese transport regulator MntR; Provisional; Region: PRK11050
718274002677	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
718274002678	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
718274002679	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
718274002680	transmembrane helices; other site
718274002681	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
718274002682	L,D-transpeptidase; Provisional; Region: PRK10260
718274002683	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
718274002684	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
718274002685	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718274002686	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274002687	Walker A/P-loop; other site
718274002688	ATP binding site [chemical binding]; other site
718274002689	ABC transporter signature motif; other site
718274002690	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718274002691	Walker B; other site
718274002692	ABC transporter; Region: ABC_tran_2; pfam12848
718274002693	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718274002694	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
718274002695	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274002696	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
718274002697	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
718274002698	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274002699	active site
718274002700	motif I; other site
718274002701	motif II; other site
718274002702	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274002703	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
718274002704	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
718274002705	dimer interface [polypeptide binding]; other site
718274002706	active site
718274002707	glycine loop; other site
718274002708	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
718274002709	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274002710	FeS/SAM binding site; other site
718274002711	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
718274002712	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
718274002713	ATP binding site [chemical binding]; other site
718274002714	substrate interface [chemical binding]; other site
718274002715	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
718274002716	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
718274002717	dimer interface [polypeptide binding]; other site
718274002718	putative functional site; other site
718274002719	putative MPT binding site; other site
718274002720	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
718274002721	catalytic nucleophile [active]
718274002722	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
718274002723	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718274002724	Walker A/P-loop; other site
718274002725	ATP binding site [chemical binding]; other site
718274002726	Q-loop/lid; other site
718274002727	ABC transporter signature motif; other site
718274002728	Walker B; other site
718274002729	D-loop; other site
718274002730	H-loop/switch region; other site
718274002731	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718274002732	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718274002733	Walker A/P-loop; other site
718274002734	ATP binding site [chemical binding]; other site
718274002735	Q-loop/lid; other site
718274002736	ABC transporter signature motif; other site
718274002737	Walker B; other site
718274002738	D-loop; other site
718274002739	H-loop/switch region; other site
718274002740	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
718274002741	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
718274002742	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
718274002743	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
718274002744	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274002745	dimer interface [polypeptide binding]; other site
718274002746	conserved gate region; other site
718274002747	putative PBP binding loops; other site
718274002748	ABC-ATPase subunit interface; other site
718274002749	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
718274002750	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
718274002751	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274002752	dimer interface [polypeptide binding]; other site
718274002753	conserved gate region; other site
718274002754	putative PBP binding loops; other site
718274002755	ABC-ATPase subunit interface; other site
718274002756	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
718274002757	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
718274002758	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274002759	FeS/SAM binding site; other site
718274002760	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
718274002761	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
718274002762	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
718274002763	Ligand binding site [chemical binding]; other site
718274002764	Electron transfer flavoprotein domain; Region: ETF; pfam01012
718274002765	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
718274002766	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
718274002767	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
718274002768	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
718274002769	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
718274002770	active site
718274002771	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
718274002772	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718274002773	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
718274002774	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
718274002775	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274002776	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274002777	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
718274002778	putative dimerization interface [polypeptide binding]; other site
718274002779	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
718274002780	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274002781	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274002782	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274002783	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
718274002784	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
718274002785	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
718274002786	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
718274002787	putative C-terminal domain interface [polypeptide binding]; other site
718274002788	putative GSH binding site (G-site) [chemical binding]; other site
718274002789	putative dimer interface [polypeptide binding]; other site
718274002790	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
718274002791	putative N-terminal domain interface [polypeptide binding]; other site
718274002792	putative dimer interface [polypeptide binding]; other site
718274002793	putative substrate binding pocket (H-site) [chemical binding]; other site
718274002794	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
718274002795	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
718274002796	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
718274002797	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
718274002798	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
718274002799	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274002800	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
718274002801	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
718274002802	active site
718274002803	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
718274002804	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274002805	putative substrate translocation pore; other site
718274002806	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
718274002807	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274002808	active site
718274002809	motif I; other site
718274002810	motif II; other site
718274002811	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274002812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274002813	putative substrate translocation pore; other site
718274002814	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718274002815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
718274002816	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274002817	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
718274002818	putative transporter; Provisional; Region: PRK04972
718274002819	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
718274002820	TrkA-C domain; Region: TrkA_C; pfam02080
718274002821	TrkA-C domain; Region: TrkA_C; pfam02080
718274002822	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
718274002823	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
718274002824	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
718274002825	GSH binding site [chemical binding]; other site
718274002826	catalytic residues [active]
718274002827	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
718274002828	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
718274002829	dimer interface [polypeptide binding]; other site
718274002830	FMN binding site [chemical binding]; other site
718274002831	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
718274002832	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274002833	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274002834	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274002835	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
718274002836	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
718274002837	RimK-like ATP-grasp domain; Region: RimK; pfam08443
718274002838	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
718274002839	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
718274002840	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
718274002841	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
718274002842	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274002843	Walker A/P-loop; other site
718274002844	ATP binding site [chemical binding]; other site
718274002845	Q-loop/lid; other site
718274002846	ABC transporter signature motif; other site
718274002847	Walker B; other site
718274002848	D-loop; other site
718274002849	H-loop/switch region; other site
718274002850	TOBE domain; Region: TOBE_2; pfam08402
718274002851	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
718274002852	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274002853	dimer interface [polypeptide binding]; other site
718274002854	conserved gate region; other site
718274002855	putative PBP binding loops; other site
718274002856	ABC-ATPase subunit interface; other site
718274002857	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
718274002858	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274002859	dimer interface [polypeptide binding]; other site
718274002860	conserved gate region; other site
718274002861	putative PBP binding loops; other site
718274002862	ABC-ATPase subunit interface; other site
718274002863	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
718274002864	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
718274002865	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274002866	S-adenosylmethionine binding site [chemical binding]; other site
718274002867	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
718274002868	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
718274002869	active site
718274002870	P-loop; other site
718274002871	phosphorylation site [posttranslational modification]
718274002872	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
718274002873	Sulfatase; Region: Sulfatase; cl17466
718274002874	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
718274002875	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274002876	substrate binding pocket [chemical binding]; other site
718274002877	membrane-bound complex binding site; other site
718274002878	hinge residues; other site
718274002879	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274002880	dimer interface [polypeptide binding]; other site
718274002881	conserved gate region; other site
718274002882	putative PBP binding loops; other site
718274002883	ABC-ATPase subunit interface; other site
718274002884	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718274002885	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274002886	dimer interface [polypeptide binding]; other site
718274002887	conserved gate region; other site
718274002888	putative PBP binding loops; other site
718274002889	ABC-ATPase subunit interface; other site
718274002890	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
718274002891	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274002892	substrate binding pocket [chemical binding]; other site
718274002893	membrane-bound complex binding site; other site
718274002894	hinge residues; other site
718274002895	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
718274002896	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274002897	Walker A/P-loop; other site
718274002898	ATP binding site [chemical binding]; other site
718274002899	Q-loop/lid; other site
718274002900	ABC transporter signature motif; other site
718274002901	Walker B; other site
718274002902	D-loop; other site
718274002903	H-loop/switch region; other site
718274002904	putative lipoprotein; Provisional; Region: PRK10533
718274002905	hypothetical protein; Provisional; Region: PRK02877
718274002906	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
718274002907	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
718274002908	amidase catalytic site [active]
718274002909	Zn binding residues [ion binding]; other site
718274002910	substrate binding site [chemical binding]; other site
718274002911	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
718274002912	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718274002913	NAD(P) binding site [chemical binding]; other site
718274002914	active site
718274002915	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
718274002916	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
718274002917	putative NAD(P) binding site [chemical binding]; other site
718274002918	putative active site [active]
718274002919	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
718274002920	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
718274002921	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
718274002922	tetramer interface [polypeptide binding]; other site
718274002923	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274002924	catalytic residue [active]
718274002925	pyruvate dehydrogenase; Provisional; Region: PRK09124
718274002926	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
718274002927	PYR/PP interface [polypeptide binding]; other site
718274002928	dimer interface [polypeptide binding]; other site
718274002929	tetramer interface [polypeptide binding]; other site
718274002930	TPP binding site [chemical binding]; other site
718274002931	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
718274002932	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
718274002933	TPP-binding site [chemical binding]; other site
718274002934	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
718274002935	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
718274002936	FAD binding pocket [chemical binding]; other site
718274002937	FAD binding motif [chemical binding]; other site
718274002938	phosphate binding motif [ion binding]; other site
718274002939	beta-alpha-beta structure motif; other site
718274002940	NAD binding pocket [chemical binding]; other site
718274002941	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
718274002942	catalytic loop [active]
718274002943	iron binding site [ion binding]; other site
718274002944	hybrid cluster protein; Provisional; Region: PRK05290
718274002945	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718274002946	ACS interaction site; other site
718274002947	CODH interaction site; other site
718274002948	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
718274002949	hybrid metal cluster; other site
718274002950	Predicted membrane protein [Function unknown]; Region: COG2431
718274002951	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
718274002952	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
718274002953	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
718274002954	putative active site [active]
718274002955	putative metal-binding site [ion binding]; other site
718274002956	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
718274002957	macrolide transporter subunit MacA; Provisional; Region: PRK11578
718274002958	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718274002959	HlyD family secretion protein; Region: HlyD_3; pfam13437
718274002960	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
718274002961	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718274002962	Walker A/P-loop; other site
718274002963	ATP binding site [chemical binding]; other site
718274002964	Q-loop/lid; other site
718274002965	ABC transporter signature motif; other site
718274002966	Walker B; other site
718274002967	D-loop; other site
718274002968	H-loop/switch region; other site
718274002969	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718274002970	FtsX-like permease family; Region: FtsX; pfam02687
718274002971	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
718274002972	DNA-binding site [nucleotide binding]; DNA binding site
718274002973	RNA-binding motif; other site
718274002974	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
718274002975	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
718274002976	Clp amino terminal domain; Region: Clp_N; pfam02861
718274002977	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274002978	Walker A motif; other site
718274002979	ATP binding site [chemical binding]; other site
718274002980	Walker B motif; other site
718274002981	arginine finger; other site
718274002982	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274002983	Walker A motif; other site
718274002984	ATP binding site [chemical binding]; other site
718274002985	Walker B motif; other site
718274002986	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
718274002987	Transposase IS200 like; Region: Y1_Tnp; pfam01797
718274002988	Integrase core domain; Region: rve; pfam00665
718274002989	Integrase core domain; Region: rve_3; pfam13683
718274002990	Helix-turn-helix domain; Region: HTH_28; pfam13518
718274002991	Isochorismatase family; Region: Isochorismatase; pfam00857
718274002992	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
718274002993	catalytic triad [active]
718274002994	dimer interface [polypeptide binding]; other site
718274002995	conserved cis-peptide bond; other site
718274002996	Pirin-related protein [General function prediction only]; Region: COG1741
718274002997	Pirin; Region: Pirin; pfam02678
718274002998	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
718274002999	LysR family transcriptional regulator; Provisional; Region: PRK14997
718274003000	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274003001	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
718274003002	putative effector binding pocket; other site
718274003003	putative dimerization interface [polypeptide binding]; other site
718274003004	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
718274003005	rRNA binding site [nucleotide binding]; other site
718274003006	predicted 30S ribosome binding site; other site
718274003007	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
718274003008	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
718274003009	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718274003010	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274003011	Walker A/P-loop; other site
718274003012	ATP binding site [chemical binding]; other site
718274003013	Q-loop/lid; other site
718274003014	ABC transporter signature motif; other site
718274003015	Walker B; other site
718274003016	D-loop; other site
718274003017	H-loop/switch region; other site
718274003018	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
718274003019	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718274003020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274003021	Walker A/P-loop; other site
718274003022	ATP binding site [chemical binding]; other site
718274003023	Q-loop/lid; other site
718274003024	ABC transporter signature motif; other site
718274003025	Walker B; other site
718274003026	D-loop; other site
718274003027	H-loop/switch region; other site
718274003028	thioredoxin reductase; Provisional; Region: PRK10262
718274003029	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718274003030	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274003031	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
718274003032	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718274003033	putative DNA binding site [nucleotide binding]; other site
718274003034	putative Zn2+ binding site [ion binding]; other site
718274003035	AsnC family; Region: AsnC_trans_reg; pfam01037
718274003036	DNA translocase FtsK; Provisional; Region: PRK10263
718274003037	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
718274003038	DNA translocase FtsK; Provisional; Region: PRK10263
718274003039	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
718274003040	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
718274003041	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
718274003042	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
718274003043	recombination factor protein RarA; Reviewed; Region: PRK13342
718274003044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274003045	Walker A motif; other site
718274003046	ATP binding site [chemical binding]; other site
718274003047	Walker B motif; other site
718274003048	arginine finger; other site
718274003049	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
718274003050	seryl-tRNA synthetase; Provisional; Region: PRK05431
718274003051	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
718274003052	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
718274003053	dimer interface [polypeptide binding]; other site
718274003054	active site
718274003055	motif 1; other site
718274003056	motif 2; other site
718274003057	motif 3; other site
718274003058	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
718274003059	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
718274003060	putative [Fe4-S4] binding site [ion binding]; other site
718274003061	putative molybdopterin cofactor binding site [chemical binding]; other site
718274003062	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
718274003063	putative molybdopterin cofactor binding site; other site
718274003064	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
718274003065	4Fe-4S binding domain; Region: Fer4; pfam00037
718274003066	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
718274003067	putative MFS family transporter protein; Provisional; Region: PRK03633
718274003068	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274003069	putative substrate translocation pore; other site
718274003070	inner membrane transporter YjeM; Provisional; Region: PRK15238
718274003071	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
718274003072	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274003073	FeS/SAM binding site; other site
718274003074	pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380
718274003075	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
718274003076	Pyruvate formate lyase 1; Region: PFL1; cd01678
718274003077	coenzyme A binding site [chemical binding]; other site
718274003078	active site
718274003079	catalytic residues [active]
718274003080	glycine loop; other site
718274003081	formate transporter; Provisional; Region: PRK10805
718274003082	uncharacterized domain; Region: TIGR00702
718274003083	YcaO-like family; Region: YcaO; pfam02624
718274003084	Predicted membrane protein [Function unknown]; Region: COG2323
718274003085	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
718274003086	homodimer interface [polypeptide binding]; other site
718274003087	substrate-cofactor binding pocket; other site
718274003088	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274003089	catalytic residue [active]
718274003090	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
718274003091	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
718274003092	hinge; other site
718274003093	active site
718274003094	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
718274003095	cytidylate kinase; Provisional; Region: cmk; PRK00023
718274003096	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
718274003097	CMP-binding site; other site
718274003098	The sites determining sugar specificity; other site
718274003099	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
718274003100	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
718274003101	RNA binding site [nucleotide binding]; other site
718274003102	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
718274003103	RNA binding site [nucleotide binding]; other site
718274003104	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
718274003105	RNA binding site [nucleotide binding]; other site
718274003106	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
718274003107	RNA binding site [nucleotide binding]; other site
718274003108	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
718274003109	RNA binding site [nucleotide binding]; other site
718274003110	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
718274003111	IHF dimer interface [polypeptide binding]; other site
718274003112	IHF - DNA interface [nucleotide binding]; other site
718274003113	ComEC family competence protein; Provisional; Region: PRK11539
718274003114	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
718274003115	Competence protein; Region: Competence; pfam03772
718274003116	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
718274003117	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
718274003118	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718274003119	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
718274003120	Walker A/P-loop; other site
718274003121	ATP binding site [chemical binding]; other site
718274003122	Q-loop/lid; other site
718274003123	ABC transporter signature motif; other site
718274003124	Walker B; other site
718274003125	D-loop; other site
718274003126	H-loop/switch region; other site
718274003127	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
718274003128	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
718274003129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
718274003130	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
718274003131	hypothetical protein; Provisional; Region: PRK11827
718274003132	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
718274003133	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
718274003134	Ligand binding site; other site
718274003135	oligomer interface; other site
718274003136	hypothetical protein; Provisional; Region: PRK10593
718274003137	Uncharacterized conserved protein [Function unknown]; Region: COG1434
718274003138	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
718274003139	putative active site [active]
718274003140	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
718274003141	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274003142	S-adenosylmethionine binding site [chemical binding]; other site
718274003143	condesin subunit F; Provisional; Region: PRK05260
718274003144	condesin subunit E; Provisional; Region: PRK05256
718274003145	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
718274003146	P-loop containing region of AAA domain; Region: AAA_29; cl17516
718274003147	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
718274003148	murein L,D-transpeptidase; Provisional; Region: PRK10594
718274003149	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
718274003150	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
718274003151	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
718274003152	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
718274003153	Peptidase M15; Region: Peptidase_M15_3; cl01194
718274003154	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
718274003155	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
718274003156	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718274003157	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274003158	homodimer interface [polypeptide binding]; other site
718274003159	catalytic residue [active]
718274003160	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
718274003161	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
718274003162	trimer interface [polypeptide binding]; other site
718274003163	eyelet of channel; other site
718274003164	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
718274003165	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
718274003166	putative dimer interface [polypeptide binding]; other site
718274003167	putative anticodon binding site; other site
718274003168	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
718274003169	homodimer interface [polypeptide binding]; other site
718274003170	motif 1; other site
718274003171	motif 2; other site
718274003172	active site
718274003173	motif 3; other site
718274003174	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
718274003175	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718274003176	putative DNA binding site [nucleotide binding]; other site
718274003177	putative Zn2+ binding site [ion binding]; other site
718274003178	AsnC family; Region: AsnC_trans_reg; pfam01037
718274003179	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
718274003180	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
718274003181	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718274003182	catalytic residue [active]
718274003183	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
718274003184	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
718274003185	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
718274003186	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
718274003187	active site
718274003188	prophage region Salmonella phage Gifsy-2
718274003189	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
718274003190	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
718274003191	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
718274003192	Int/Topo IB signature motif; other site
718274003193	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
718274003194	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
718274003195	RecT family; Region: RecT; pfam03837
718274003196	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
718274003197	exonuclease VIII; Reviewed; Region: PRK09709
718274003198	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
718274003199	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274003200	non-specific DNA binding site [nucleotide binding]; other site
718274003201	salt bridge; other site
718274003202	sequence-specific DNA binding site [nucleotide binding]; other site
718274003203	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
718274003204	DNA binding residues [nucleotide binding]
718274003205	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
718274003206	primosomal protein DnaI; Provisional; Region: PRK02854
718274003207	putative replication protein; Provisional; Region: PRK12377
718274003208	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274003209	Walker A motif; other site
718274003210	ATP binding site [chemical binding]; other site
718274003211	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
718274003212	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
718274003213	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
718274003214	DinI-like family; Region: DinI; pfam06183
718274003215	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
718274003216	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
718274003217	Antitermination protein; Region: Antiterm; pfam03589
718274003218	Antitermination protein; Region: Antiterm; pfam03589
718274003219	PipA protein; Region: PipA; pfam07108
718274003220	phage holin, lambda family; Region: holin_lambda; TIGR01594
718274003221	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
718274003222	catalytic residues [active]
718274003223	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
718274003224	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
718274003225	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
718274003226	Domain of unknown function (DUF1859); Region: DUF1859; pfam08948
718274003227	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
718274003228	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
718274003229	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
718274003230	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
718274003231	oligomer interface [polypeptide binding]; other site
718274003232	active site residues [active]
718274003233	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
718274003234	Uncharacterized conserved protein [Function unknown]; Region: COG5471
718274003235	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856
718274003236	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
718274003237	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
718274003238	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718274003239	phage minor tail protein G; Region: phage_lambda_G; TIGR01674
718274003240	Minor tail protein T; Region: Phage_tail_T; cl05636
718274003241	Phage-related minor tail protein [Function unknown]; Region: COG5281
718274003242	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
718274003243	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
718274003244	Phage-related protein [Function unknown]; Region: COG4718
718274003245	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
718274003246	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
718274003247	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
718274003248	E-class dimer interface [polypeptide binding]; other site
718274003249	P-class dimer interface [polypeptide binding]; other site
718274003250	active site
718274003251	Cu2+ binding site [ion binding]; other site
718274003252	Zn2+ binding site [ion binding]; other site
718274003253	Phage-related protein [Function unknown]; Region: gp18; COG4672
718274003254	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
718274003255	MPN+ (JAMM) motif; other site
718274003256	Zinc-binding site [ion binding]; other site
718274003257	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718274003258	NlpC/P60 family; Region: NLPC_P60; cl17555
718274003259	Phage-related protein, tail component [Function unknown]; Region: COG4723
718274003260	Phage-related protein, tail component [Function unknown]; Region: COG4733
718274003261	Putative phage tail protein; Region: Phage-tail_3; pfam13550
718274003262	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718274003263	Interdomain contacts; other site
718274003264	Cytokine receptor motif; other site
718274003265	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
718274003266	Fibronectin type III protein; Region: DUF3672; pfam12421
718274003267	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
718274003268	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
718274003269	Phage Tail Collar Domain; Region: Collar; pfam07484
718274003270	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
718274003271	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
718274003272	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
718274003273	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
718274003274	hypothetical protein; Provisional; Region: PRK09951
718274003275	DinI-like family; Region: DinI; cl11630
718274003276	aminopeptidase N; Provisional; Region: pepN; PRK14015
718274003277	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
718274003278	active site
718274003279	Zn binding site [ion binding]; other site
718274003280	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
718274003281	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
718274003282	quinone interaction residues [chemical binding]; other site
718274003283	active site
718274003284	catalytic residues [active]
718274003285	FMN binding site [chemical binding]; other site
718274003286	substrate binding site [chemical binding]; other site
718274003287	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
718274003288	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
718274003289	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
718274003290	MOSC domain; Region: MOSC; pfam03473
718274003291	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
718274003292	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
718274003293	catalytic loop [active]
718274003294	iron binding site [ion binding]; other site
718274003295	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
718274003296	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
718274003297	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
718274003298	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274003299	S-adenosylmethionine binding site [chemical binding]; other site
718274003300	ABC transporter ATPase component; Reviewed; Region: PRK11147
718274003301	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274003302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274003303	Walker A/P-loop; other site
718274003304	Walker A/P-loop; other site
718274003305	ATP binding site [chemical binding]; other site
718274003306	ATP binding site [chemical binding]; other site
718274003307	Q-loop/lid; other site
718274003308	Q-loop/lid; other site
718274003309	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718274003310	ABC transporter signature motif; other site
718274003311	Walker B; other site
718274003312	D-loop; other site
718274003313	ABC transporter; Region: ABC_tran_2; pfam12848
718274003314	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718274003315	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
718274003316	Paraquat-inducible protein A; Region: PqiA; pfam04403
718274003317	Paraquat-inducible protein A; Region: PqiA; pfam04403
718274003318	paraquat-inducible protein B; Provisional; Region: PRK10807
718274003319	mce related protein; Region: MCE; pfam02470
718274003320	mce related protein; Region: MCE; pfam02470
718274003321	mce related protein; Region: MCE; pfam02470
718274003322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
718274003323	Protein of unknown function (DUF330); Region: DUF330; pfam03886
718274003324	ribosome modulation factor; Provisional; Region: PRK14563
718274003325	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
718274003326	active site 1 [active]
718274003327	dimer interface [polypeptide binding]; other site
718274003328	active site 2 [active]
718274003329	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
718274003330	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
718274003331	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
718274003332	outer membrane protein A; Reviewed; Region: PRK10808
718274003333	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
718274003334	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
718274003335	ligand binding site [chemical binding]; other site
718274003336	cell division inhibitor SulA; Region: sula; TIGR00623
718274003337	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
718274003338	TfoX C-terminal domain; Region: TfoX_C; pfam04994
718274003339	TIGR01666 family membrane protein; Region: YCCS
718274003340	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
718274003341	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
718274003342	Predicted membrane protein [Function unknown]; Region: COG3304
718274003343	Domain of unknown function (DUF307); Region: DUF307; pfam03733
718274003344	Domain of unknown function (DUF307); Region: DUF307; pfam03733
718274003345	DNA helicase IV; Provisional; Region: helD; PRK11054
718274003346	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
718274003347	Part of AAA domain; Region: AAA_19; pfam13245
718274003348	Family description; Region: UvrD_C_2; pfam13538
718274003349	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
718274003350	active site
718274003351	dimer interfaces [polypeptide binding]; other site
718274003352	catalytic residues [active]
718274003353	hypothetical protein; Provisional; Region: PRK03641
718274003354	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110
718274003355	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
718274003356	heat shock protein HspQ; Provisional; Region: PRK14129
718274003357	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
718274003358	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
718274003359	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
718274003360	putative RNA binding site [nucleotide binding]; other site
718274003361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274003362	S-adenosylmethionine binding site [chemical binding]; other site
718274003363	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
718274003364	substrate binding site [chemical binding]; other site
718274003365	Cupin domain; Region: Cupin_2; cl17218
718274003366	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718274003367	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274003368	acylphosphatase; Provisional; Region: PRK14426
718274003369	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
718274003370	sulfur transfer protein TusE; Provisional; Region: PRK11508
718274003371	YccA-like proteins; Region: YccA_like; cd10433
718274003372	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
718274003373	PipA protein; Region: PipA; pfam07108
718274003374	secreted effector protein PipB; Provisional; Region: PRK15197
718274003375	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
718274003376	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
718274003377	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
718274003378	type III secretion chaperone protein SigE; Provisional; Region: PRK15202
718274003379	inositol phosphate phosphatase SopB; Provisional; Region: PRK15378
718274003380	Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925
718274003381	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
718274003382	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
718274003383	HAMP domain; Region: HAMP; pfam00672
718274003384	dimerization interface [polypeptide binding]; other site
718274003385	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274003386	dimer interface [polypeptide binding]; other site
718274003387	phosphorylation site [posttranslational modification]
718274003388	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274003389	ATP binding site [chemical binding]; other site
718274003390	Mg2+ binding site [ion binding]; other site
718274003391	G-X-G motif; other site
718274003392	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
718274003393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274003394	active site
718274003395	phosphorylation site [posttranslational modification]
718274003396	intermolecular recognition site; other site
718274003397	dimerization interface [polypeptide binding]; other site
718274003398	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274003399	DNA binding site [nucleotide binding]
718274003400	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
718274003401	active site
718274003402	homotetramer interface [polypeptide binding]; other site
718274003403	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
718274003404	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
718274003405	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
718274003406	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
718274003407	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
718274003408	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203
718274003409	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
718274003410	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
718274003411	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
718274003412	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
718274003413	NAD binding site [chemical binding]; other site
718274003414	catalytic residues [active]
718274003415	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
718274003416	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
718274003417	putative active site [active]
718274003418	putative metal binding site [ion binding]; other site
718274003419	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
718274003420	putative substrate binding pocket [chemical binding]; other site
718274003421	trimer interface [polypeptide binding]; other site
718274003422	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
718274003423	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
718274003424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274003425	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
718274003426	putative substrate translocation pore; other site
718274003427	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
718274003428	Cupin domain; Region: Cupin_2; pfam07883
718274003429	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274003430	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
718274003431	anti-adapter protein IraM; Provisional; Region: PRK09919
718274003432	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
718274003433	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
718274003434	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
718274003435	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
718274003436	HSP70 interaction site [polypeptide binding]; other site
718274003437	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
718274003438	substrate binding site [polypeptide binding]; other site
718274003439	dimer interface [polypeptide binding]; other site
718274003440	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
718274003441	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
718274003442	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
718274003443	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
718274003444	DsbD alpha interface [polypeptide binding]; other site
718274003445	catalytic residues [active]
718274003446	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
718274003447	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
718274003448	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
718274003449	catalytic residues [active]
718274003450	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
718274003451	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
718274003452	catalytic residues [active]
718274003453	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
718274003454	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
718274003455	catalytic core [active]
718274003456	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
718274003457	hypothetical protein; Provisional; Region: PRK10174
718274003458	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
718274003459	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
718274003460	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
718274003461	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274003462	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
718274003463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
718274003464	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
718274003465	Predicted transcriptional regulator [Transcription]; Region: COG3905
718274003466	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
718274003467	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
718274003468	Glutamate binding site [chemical binding]; other site
718274003469	NAD binding site [chemical binding]; other site
718274003470	catalytic residues [active]
718274003471	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
718274003472	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
718274003473	Na binding site [ion binding]; other site
718274003474	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
718274003475	hypothetical protein; Provisional; Region: PRK10536
718274003476	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
718274003477	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
718274003478	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
718274003479	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
718274003480	putative active site [active]
718274003481	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
718274003482	Na binding site [ion binding]; other site
718274003483	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
718274003484	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
718274003485	putative active site cavity [active]
718274003486	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
718274003487	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
718274003488	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
718274003489	putative sialic acid transporter; Provisional; Region: PRK12307
718274003490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274003491	putative substrate translocation pore; other site
718274003492	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
718274003493	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
718274003494	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
718274003495	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
718274003496	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
718274003497	putative ligand binding site [chemical binding]; other site
718274003498	NAD binding site [chemical binding]; other site
718274003499	dimerization interface [polypeptide binding]; other site
718274003500	catalytic site [active]
718274003501	putative hydrolase; Validated; Region: PRK09248
718274003502	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
718274003503	active site
718274003504	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
718274003505	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
718274003506	curli production assembly/transport protein CsgG; Provisional; Region: PRK15184
718274003507	curli assembly protein CsgF; Provisional; Region: PRK10050
718274003508	curli assembly protein CsgE; Provisional; Region: PRK10386
718274003509	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
718274003510	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274003511	DNA binding residues [nucleotide binding]
718274003512	dimerization interface [polypeptide binding]; other site
718274003513	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
718274003514	Curlin associated repeat; Region: Curlin_rpt; pfam07012
718274003515	Curlin associated repeat; Region: Curlin_rpt; pfam07012
718274003516	major curlin subunit; Provisional; Region: csgA; PRK10051
718274003517	Curlin associated repeat; Region: Curlin_rpt; pfam07012
718274003518	curli assembly protein CsgC; Provisional; Region: csgC; PRK10102
718274003519	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
718274003520	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
718274003521	putative ADP-ribose binding site [chemical binding]; other site
718274003522	putative active site [active]
718274003523	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
718274003524	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
718274003525	putative active site [active]
718274003526	catalytic site [active]
718274003527	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
718274003528	putative active site [active]
718274003529	catalytic site [active]
718274003530	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
718274003531	Acyltransferase family; Region: Acyl_transf_3; pfam01757
718274003532	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
718274003533	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349
718274003534	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
718274003535	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
718274003536	Ligand binding site; other site
718274003537	DXD motif; other site
718274003538	lipoprotein; Provisional; Region: PRK10175
718274003539	secY/secA suppressor protein; Provisional; Region: PRK11467
718274003540	drug efflux system protein MdtG; Provisional; Region: PRK09874
718274003541	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274003542	putative substrate translocation pore; other site
718274003543	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
718274003544	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
718274003545	putative acyl-acceptor binding pocket; other site
718274003546	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
718274003547	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
718274003548	active site residue [active]
718274003549	hypothetical protein; Provisional; Region: PRK03757
718274003550	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
718274003551	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
718274003552	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
718274003553	hydroxyglutarate oxidase; Provisional; Region: PRK11728
718274003554	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
718274003555	DNA damage-inducible protein I; Provisional; Region: PRK10597
718274003556	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
718274003557	active site
718274003558	substrate binding pocket [chemical binding]; other site
718274003559	dimer interface [polypeptide binding]; other site
718274003560	lipoprotein; Provisional; Region: PRK10598
718274003561	glutaredoxin 2; Provisional; Region: PRK10387
718274003562	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
718274003563	C-terminal domain interface [polypeptide binding]; other site
718274003564	GSH binding site (G-site) [chemical binding]; other site
718274003565	catalytic residues [active]
718274003566	putative dimer interface [polypeptide binding]; other site
718274003567	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
718274003568	N-terminal domain interface [polypeptide binding]; other site
718274003569	multidrug resistance protein MdtH; Provisional; Region: PRK11646
718274003570	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274003571	putative substrate translocation pore; other site
718274003572	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
718274003573	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
718274003574	hypothetical protein; Provisional; Region: PRK11239
718274003575	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
718274003576	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
718274003577	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
718274003578	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
718274003579	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
718274003580	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
718274003581	flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459
718274003582	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
718274003583	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
718274003584	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
718274003585	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
718274003586	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
718274003587	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
718274003588	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
718274003589	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
718274003590	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
718274003591	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
718274003592	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
718274003593	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
718274003594	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
718274003595	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
718274003596	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
718274003597	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
718274003598	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
718274003599	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
718274003600	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
718274003601	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
718274003602	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
718274003603	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
718274003604	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
718274003605	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
718274003606	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
718274003607	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
718274003608	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
718274003609	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
718274003610	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
718274003611	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
718274003612	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
718274003613	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
718274003614	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
718274003615	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
718274003616	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
718274003617	homodimer interface [polypeptide binding]; other site
718274003618	oligonucleotide binding site [chemical binding]; other site
718274003619	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
718274003620	Protein of unknown function (DUF2655); Region: DUF2655; pfam10848
718274003621	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
718274003622	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718274003623	RNA binding surface [nucleotide binding]; other site
718274003624	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
718274003625	active site
718274003626	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
718274003627	Maf-like protein; Region: Maf; pfam02545
718274003628	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
718274003629	active site
718274003630	dimer interface [polypeptide binding]; other site
718274003631	hypothetical protein; Provisional; Region: PRK11193
718274003632	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
718274003633	putative phosphate acyltransferase; Provisional; Region: PRK05331
718274003634	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
718274003635	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
718274003636	dimer interface [polypeptide binding]; other site
718274003637	active site
718274003638	CoA binding pocket [chemical binding]; other site
718274003639	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
718274003640	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
718274003641	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
718274003642	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
718274003643	NAD(P) binding site [chemical binding]; other site
718274003644	homotetramer interface [polypeptide binding]; other site
718274003645	homodimer interface [polypeptide binding]; other site
718274003646	active site
718274003647	acyl carrier protein; Provisional; Region: acpP; PRK00982
718274003648	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
718274003649	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
718274003650	dimer interface [polypeptide binding]; other site
718274003651	active site
718274003652	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
718274003653	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
718274003654	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274003655	catalytic residue [active]
718274003656	conserved hypothetical protein, YceG family; Region: TIGR00247
718274003657	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
718274003658	dimerization interface [polypeptide binding]; other site
718274003659	thymidylate kinase; Validated; Region: tmk; PRK00698
718274003660	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
718274003661	TMP-binding site; other site
718274003662	ATP-binding site [chemical binding]; other site
718274003663	DNA polymerase III subunit delta'; Validated; Region: PRK07993
718274003664	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
718274003665	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
718274003666	active site
718274003667	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
718274003668	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
718274003669	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
718274003670	active site turn [active]
718274003671	phosphorylation site [posttranslational modification]
718274003672	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
718274003673	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
718274003674	N-terminal plug; other site
718274003675	ligand-binding site [chemical binding]; other site
718274003676	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
718274003677	nucleotide binding site/active site [active]
718274003678	HIT family signature motif; other site
718274003679	catalytic residue [active]
718274003680	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
718274003681	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
718274003682	putative dimer interface [polypeptide binding]; other site
718274003683	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
718274003684	thiamine kinase; Region: ycfN_thiK; TIGR02721
718274003685	thiamine kinase; Provisional; Region: thiK; PRK10271
718274003686	substrate binding site [chemical binding]; other site
718274003687	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
718274003688	beta-hexosaminidase; Provisional; Region: PRK05337
718274003689	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
718274003690	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
718274003691	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274003692	hypothetical protein; Provisional; Region: PRK11280
718274003693	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
718274003694	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274003695	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
718274003696	L,D-transpeptidase; Provisional; Region: PRK10190
718274003697	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718274003698	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
718274003699	transcription-repair coupling factor; Provisional; Region: PRK10689
718274003700	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
718274003701	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718274003702	ATP binding site [chemical binding]; other site
718274003703	putative Mg++ binding site [ion binding]; other site
718274003704	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274003705	nucleotide binding region [chemical binding]; other site
718274003706	ATP-binding site [chemical binding]; other site
718274003707	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
718274003708	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
718274003709	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718274003710	FtsX-like permease family; Region: FtsX; pfam02687
718274003711	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
718274003712	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718274003713	Walker A/P-loop; other site
718274003714	ATP binding site [chemical binding]; other site
718274003715	Q-loop/lid; other site
718274003716	ABC transporter signature motif; other site
718274003717	Walker B; other site
718274003718	D-loop; other site
718274003719	H-loop/switch region; other site
718274003720	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
718274003721	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718274003722	FtsX-like permease family; Region: FtsX; pfam02687
718274003723	fructokinase; Reviewed; Region: PRK09557
718274003724	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718274003725	nucleotide binding site [chemical binding]; other site
718274003726	NAD-dependent deacetylase; Provisional; Region: PRK00481
718274003727	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
718274003728	NAD+ binding site [chemical binding]; other site
718274003729	substrate binding site [chemical binding]; other site
718274003730	Zn binding site [ion binding]; other site
718274003731	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
718274003732	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
718274003733	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
718274003734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274003735	dimer interface [polypeptide binding]; other site
718274003736	conserved gate region; other site
718274003737	putative PBP binding loops; other site
718274003738	ABC-ATPase subunit interface; other site
718274003739	Sif protein; Region: Sif; pfam06767
718274003740	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718274003741	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274003742	dimer interface [polypeptide binding]; other site
718274003743	conserved gate region; other site
718274003744	putative PBP binding loops; other site
718274003745	ABC-ATPase subunit interface; other site
718274003746	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
718274003747	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274003748	Walker A/P-loop; other site
718274003749	ATP binding site [chemical binding]; other site
718274003750	Q-loop/lid; other site
718274003751	ABC transporter signature motif; other site
718274003752	Walker B; other site
718274003753	D-loop; other site
718274003754	H-loop/switch region; other site
718274003755	TOBE domain; Region: TOBE_2; pfam08402
718274003756	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
718274003757	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
718274003758	metal binding site [ion binding]; metal-binding site
718274003759	dimer interface [polypeptide binding]; other site
718274003760	Uncharacterized conserved protein [Function unknown]; Region: COG2850
718274003761	Cupin-like domain; Region: Cupin_8; pfam13621
718274003762	sensor protein PhoQ; Provisional; Region: PRK10815
718274003763	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
718274003764	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
718274003765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274003766	ATP binding site [chemical binding]; other site
718274003767	Mg2+ binding site [ion binding]; other site
718274003768	G-X-G motif; other site
718274003769	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
718274003770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274003771	active site
718274003772	phosphorylation site [posttranslational modification]
718274003773	intermolecular recognition site; other site
718274003774	dimerization interface [polypeptide binding]; other site
718274003775	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274003776	DNA binding site [nucleotide binding]
718274003777	adenylosuccinate lyase; Provisional; Region: PRK09285
718274003778	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
718274003779	tetramer interface [polypeptide binding]; other site
718274003780	active site
718274003781	putative lysogenization regulator; Reviewed; Region: PRK00218
718274003782	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
718274003783	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
718274003784	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
718274003785	nudix motif; other site
718274003786	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
718274003787	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
718274003788	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
718274003789	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
718274003790	probable active site [active]
718274003791	isocitrate dehydrogenase; Validated; Region: PRK07362
718274003792	isocitrate dehydrogenase; Reviewed; Region: PRK07006
718274003793	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
718274003794	DinI-like family; Region: DinI; pfam06183
718274003795	Ricin-type beta-trefoil; Region: RICIN; smart00458
718274003796	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
718274003797	putative sugar binding sites [chemical binding]; other site
718274003798	Q-X-W motif; other site
718274003799	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
718274003800	DNA-binding site [nucleotide binding]; DNA binding site
718274003801	RNA-binding motif; other site
718274003802	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
718274003803	lysozyme inhibitor; Provisional; Region: PRK13791
718274003804	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
718274003805	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
718274003806	putative dimer interface [polypeptide binding]; other site
718274003807	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
718274003808	BNR repeat-like domain; Region: BNR_2; pfam13088
718274003809	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
718274003810	TRL-like protein family; Region: TRL; pfam13146
718274003811	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
718274003812	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
718274003813	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
718274003814	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274003815	dimer interface [polypeptide binding]; other site
718274003816	conserved gate region; other site
718274003817	ABC-ATPase subunit interface; other site
718274003818	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
718274003819	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274003820	dimer interface [polypeptide binding]; other site
718274003821	conserved gate region; other site
718274003822	putative PBP binding loops; other site
718274003823	ABC-ATPase subunit interface; other site
718274003824	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718274003825	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
718274003826	Walker A/P-loop; other site
718274003827	ATP binding site [chemical binding]; other site
718274003828	Q-loop/lid; other site
718274003829	ABC transporter signature motif; other site
718274003830	Walker B; other site
718274003831	D-loop; other site
718274003832	H-loop/switch region; other site
718274003833	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274003834	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
718274003835	Walker A/P-loop; other site
718274003836	ATP binding site [chemical binding]; other site
718274003837	Q-loop/lid; other site
718274003838	ABC transporter signature motif; other site
718274003839	Walker B; other site
718274003840	D-loop; other site
718274003841	H-loop/switch region; other site
718274003842	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
718274003843	Mechanosensitive ion channel; Region: MS_channel; pfam00924
718274003844	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
718274003845	dimerization interface [polypeptide binding]; other site
718274003846	zinc/cadmium-binding protein; Provisional; Region: PRK10306
718274003847	aminoglycoside resistance protein; Provisional; Region: PRK13746
718274003848	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
718274003849	active site
718274003850	NTP binding site [chemical binding]; other site
718274003851	metal binding triad [ion binding]; metal-binding site
718274003852	antibiotic binding site [chemical binding]; other site
718274003853	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
718274003854	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274003855	DNA binding residues [nucleotide binding]
718274003856	transcriptional regulator MirA; Provisional; Region: PRK15043
718274003857	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
718274003858	DNA binding residues [nucleotide binding]
718274003859	dimer interface [polypeptide binding]; other site
718274003860	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
718274003861	chorismate mutase; Provisional; Region: PRK08055
718274003862	leucine export protein LeuE; Provisional; Region: PRK10958
718274003863	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
718274003864	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
718274003865	hypothetical protein; Provisional; Region: PRK10457
718274003866	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
718274003867	murein hydrolase B; Provisional; Region: PRK10760; cl17906
718274003868	Domain of unknown function (DUF333); Region: DUF333; pfam03891
718274003869	Uncharacterized conserved protein [Function unknown]; Region: COG3189
718274003870	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
718274003871	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274003872	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718274003873	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274003874	Predicted membrane protein [Function unknown]; Region: COG2707
718274003875	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
718274003876	putative deacylase active site [active]
718274003877	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718274003878	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718274003879	metal binding site [ion binding]; metal-binding site
718274003880	active site
718274003881	I-site; other site
718274003882	hypothetical protein; Provisional; Region: PRK05325
718274003883	PrkA family serine protein kinase; Provisional; Region: PRK15455
718274003884	AAA ATPase domain; Region: AAA_16; pfam13191
718274003885	Walker A motif; other site
718274003886	ATP binding site [chemical binding]; other site
718274003887	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
718274003888	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
718274003889	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
718274003890	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274003891	FeS/SAM binding site; other site
718274003892	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
718274003893	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718274003894	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718274003895	active site
718274003896	catalytic tetrad [active]
718274003897	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
718274003898	active site
718274003899	phosphate binding residues; other site
718274003900	catalytic residues [active]
718274003901	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
718274003902	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
718274003903	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
718274003904	methionine sulfoxide reductase B; Provisional; Region: PRK00222
718274003905	SelR domain; Region: SelR; pfam01641
718274003906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
718274003907	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
718274003908	Isochorismatase family; Region: Isochorismatase; pfam00857
718274003909	catalytic triad [active]
718274003910	metal binding site [ion binding]; metal-binding site
718274003911	conserved cis-peptide bond; other site
718274003912	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
718274003913	active site
718274003914	homodimer interface [polypeptide binding]; other site
718274003915	protease 4; Provisional; Region: PRK10949
718274003916	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
718274003917	tandem repeat interface [polypeptide binding]; other site
718274003918	oligomer interface [polypeptide binding]; other site
718274003919	active site residues [active]
718274003920	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
718274003921	tandem repeat interface [polypeptide binding]; other site
718274003922	oligomer interface [polypeptide binding]; other site
718274003923	active site residues [active]
718274003924	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
718274003925	putative FMN binding site [chemical binding]; other site
718274003926	selenophosphate synthetase; Provisional; Region: PRK00943
718274003927	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
718274003928	dimerization interface [polypeptide binding]; other site
718274003929	putative ATP binding site [chemical binding]; other site
718274003930	DNA topoisomerase III; Provisional; Region: PRK07726
718274003931	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
718274003932	active site
718274003933	putative interdomain interaction site [polypeptide binding]; other site
718274003934	putative metal-binding site [ion binding]; other site
718274003935	putative nucleotide binding site [chemical binding]; other site
718274003936	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
718274003937	domain I; other site
718274003938	DNA binding groove [nucleotide binding]
718274003939	phosphate binding site [ion binding]; other site
718274003940	domain II; other site
718274003941	domain III; other site
718274003942	nucleotide binding site [chemical binding]; other site
718274003943	catalytic site [active]
718274003944	domain IV; other site
718274003945	glutamate dehydrogenase; Provisional; Region: PRK09414
718274003946	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
718274003947	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
718274003948	NAD(P) binding site [chemical binding]; other site
718274003949	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
718274003950	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
718274003951	active site
718274003952	8-oxo-dGMP binding site [chemical binding]; other site
718274003953	nudix motif; other site
718274003954	metal binding site [ion binding]; metal-binding site
718274003955	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
718274003956	putative catalytic site [active]
718274003957	putative phosphate binding site [ion binding]; other site
718274003958	active site
718274003959	metal binding site A [ion binding]; metal-binding site
718274003960	DNA binding site [nucleotide binding]
718274003961	putative AP binding site [nucleotide binding]; other site
718274003962	putative metal binding site B [ion binding]; other site
718274003963	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
718274003964	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
718274003965	inhibitor-cofactor binding pocket; inhibition site
718274003966	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274003967	catalytic residue [active]
718274003968	arginine succinyltransferase; Provisional; Region: PRK10456
718274003969	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
718274003970	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
718274003971	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
718274003972	NAD(P) binding site [chemical binding]; other site
718274003973	catalytic residues [active]
718274003974	succinylarginine dihydrolase; Provisional; Region: PRK13281
718274003975	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
718274003976	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
718274003977	putative active site [active]
718274003978	Zn binding site [ion binding]; other site
718274003979	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
718274003980	dimer interface [polypeptide binding]; other site
718274003981	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
718274003982	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
718274003983	GIY-YIG motif/motif A; other site
718274003984	active site
718274003985	catalytic site [active]
718274003986	putative DNA binding site [nucleotide binding]; other site
718274003987	metal binding site [ion binding]; metal-binding site
718274003988	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
718274003989	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
718274003990	homodimer interface [polypeptide binding]; other site
718274003991	NAD binding pocket [chemical binding]; other site
718274003992	ATP binding pocket [chemical binding]; other site
718274003993	Mg binding site [ion binding]; other site
718274003994	active-site loop [active]
718274003995	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
718274003996	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
718274003997	active site
718274003998	P-loop; other site
718274003999	phosphorylation site [posttranslational modification]
718274004000	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
718274004001	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
718274004002	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
718274004003	methionine cluster; other site
718274004004	active site
718274004005	phosphorylation site [posttranslational modification]
718274004006	metal binding site [ion binding]; metal-binding site
718274004007	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
718274004008	Cupin domain; Region: Cupin_2; pfam07883
718274004009	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274004010	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
718274004011	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
718274004012	NAD binding site [chemical binding]; other site
718274004013	sugar binding site [chemical binding]; other site
718274004014	divalent metal binding site [ion binding]; other site
718274004015	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718274004016	dimer interface [polypeptide binding]; other site
718274004017	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
718274004018	putative active site [active]
718274004019	YdjC motif; other site
718274004020	Mg binding site [ion binding]; other site
718274004021	putative homodimer interface [polypeptide binding]; other site
718274004022	hydroperoxidase II; Provisional; Region: katE; PRK11249
718274004023	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
718274004024	tetramer interface [polypeptide binding]; other site
718274004025	heme binding pocket [chemical binding]; other site
718274004026	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
718274004027	domain interactions; other site
718274004028	cell division modulator; Provisional; Region: PRK10113
718274004029	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
718274004030	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
718274004031	inner membrane protein; Provisional; Region: PRK11648
718274004032	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
718274004033	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
718274004034	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274004035	motif II; other site
718274004036	YniB-like protein; Region: YniB; pfam14002
718274004037	Phosphotransferase enzyme family; Region: APH; pfam01636
718274004038	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
718274004039	active site
718274004040	ATP binding site [chemical binding]; other site
718274004041	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
718274004042	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
718274004043	6-phosphofructokinase 2; Provisional; Region: PRK10294
718274004044	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
718274004045	putative substrate binding site [chemical binding]; other site
718274004046	putative ATP binding site [chemical binding]; other site
718274004047	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
718274004048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528
718274004049	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
718274004050	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
718274004051	active site
718274004052	substrate binding site [chemical binding]; other site
718274004053	Mg2+ binding site [ion binding]; other site
718274004054	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
718274004055	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
718274004056	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
718274004057	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
718274004058	active site
718274004059	dimer interface [polypeptide binding]; other site
718274004060	motif 1; other site
718274004061	motif 2; other site
718274004062	motif 3; other site
718274004063	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
718274004064	anticodon binding site; other site
718274004065	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
718274004066	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
718274004067	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
718274004068	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
718274004069	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
718274004070	23S rRNA binding site [nucleotide binding]; other site
718274004071	L21 binding site [polypeptide binding]; other site
718274004072	L13 binding site [polypeptide binding]; other site
718274004073	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
718274004074	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
718274004075	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
718274004076	dimer interface [polypeptide binding]; other site
718274004077	motif 1; other site
718274004078	active site
718274004079	motif 2; other site
718274004080	motif 3; other site
718274004081	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
718274004082	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
718274004083	putative tRNA-binding site [nucleotide binding]; other site
718274004084	B3/4 domain; Region: B3_4; pfam03483
718274004085	tRNA synthetase B5 domain; Region: B5; smart00874
718274004086	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
718274004087	dimer interface [polypeptide binding]; other site
718274004088	motif 1; other site
718274004089	motif 3; other site
718274004090	motif 2; other site
718274004091	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
718274004092	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
718274004093	IHF dimer interface [polypeptide binding]; other site
718274004094	IHF - DNA interface [nucleotide binding]; other site
718274004095	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
718274004096	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718274004097	ABC-ATPase subunit  interface; other site
718274004098	dimer interface [polypeptide binding]; other site
718274004099	putative PBP binding regions; other site
718274004100	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
718274004101	catalytic residues [active]
718274004102	dimer interface [polypeptide binding]; other site
718274004103	ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138
718274004104	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
718274004105	Walker A/P-loop; other site
718274004106	ATP binding site [chemical binding]; other site
718274004107	Q-loop/lid; other site
718274004108	ABC transporter signature motif; other site
718274004109	Walker B; other site
718274004110	D-loop; other site
718274004111	H-loop/switch region; other site
718274004112	NlpC/P60 family; Region: NLPC_P60; pfam00877
718274004113	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
718274004114	Uncharacterized conserved protein [Function unknown]; Region: COG0397
718274004115	hypothetical protein; Validated; Region: PRK00029
718274004116	hypothetical protein; Provisional; Region: PRK10183
718274004117	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
718274004118	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
718274004119	PEP synthetase regulatory protein; Provisional; Region: PRK05339
718274004120	phosphoenolpyruvate synthase; Validated; Region: PRK06464
718274004121	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
718274004122	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
718274004123	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
718274004124	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
718274004125	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
718274004126	acyl-activating enzyme (AAE) consensus motif; other site
718274004127	putative AMP binding site [chemical binding]; other site
718274004128	putative active site [active]
718274004129	putative CoA binding site [chemical binding]; other site
718274004130	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
718274004131	oxidoreductase; Provisional; Region: PRK10015
718274004132	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
718274004133	Electron transfer flavoprotein domain; Region: ETF; smart00893
718274004134	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
718274004135	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
718274004136	Ligand binding site [chemical binding]; other site
718274004137	Electron transfer flavoprotein domain; Region: ETF; pfam01012
718274004138	Cupin domain; Region: Cupin_2; pfam07883
718274004139	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718274004140	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274004141	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
718274004142	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
718274004143	active site
718274004144	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
718274004145	Coenzyme A transferase; Region: CoA_trans; smart00882
718274004146	Coenzyme A transferase; Region: CoA_trans; cl17247
718274004147	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
718274004148	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
718274004149	active site
718274004150	catalytic residue [active]
718274004151	dimer interface [polypeptide binding]; other site
718274004152	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
718274004153	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
718274004154	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
718274004155	shikimate binding site; other site
718274004156	NAD(P) binding site [chemical binding]; other site
718274004157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274004158	putative transporter; Provisional; Region: PRK03699
718274004159	putative substrate translocation pore; other site
718274004160	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274004161	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718274004162	putative substrate translocation pore; other site
718274004163	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
718274004164	putative inner membrane protein; Provisional; Region: PRK10983
718274004165	Domain of unknown function DUF20; Region: UPF0118; pfam01594
718274004166	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
718274004167	FAD binding domain; Region: FAD_binding_4; pfam01565
718274004168	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
718274004169	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
718274004170	CoenzymeA binding site [chemical binding]; other site
718274004171	subunit interaction site [polypeptide binding]; other site
718274004172	PHB binding site; other site
718274004173	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
718274004174	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
718274004175	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
718274004176	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
718274004177	putative ABC transporter; Region: ycf24; CHL00085
718274004178	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
718274004179	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
718274004180	Walker A/P-loop; other site
718274004181	ATP binding site [chemical binding]; other site
718274004182	Q-loop/lid; other site
718274004183	ABC transporter signature motif; other site
718274004184	Walker B; other site
718274004185	D-loop; other site
718274004186	H-loop/switch region; other site
718274004187	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
718274004188	FeS assembly protein SufD; Region: sufD; TIGR01981
718274004189	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
718274004190	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
718274004191	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718274004192	catalytic residue [active]
718274004193	cysteine desufuration protein SufE; Provisional; Region: PRK09296
718274004194	L,D-transpeptidase; Provisional; Region: PRK10190
718274004195	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718274004196	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
718274004197	murein lipoprotein; Provisional; Region: PRK15396
718274004198	murein lipoprotein; Provisional; Region: PRK15396
718274004199	pyruvate kinase; Provisional; Region: PRK09206
718274004200	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
718274004201	domain interfaces; other site
718274004202	active site
718274004203	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
718274004204	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
718274004205	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
718274004206	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
718274004207	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
718274004208	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718274004209	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
718274004210	substrate binding site [chemical binding]; other site
718274004211	dimer interface [polypeptide binding]; other site
718274004212	ATP binding site [chemical binding]; other site
718274004213	tetrathionate reductase subunit A; Provisional; Region: PRK14991
718274004214	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
718274004215	putative [Fe4-S4] binding site [ion binding]; other site
718274004216	putative molybdopterin cofactor binding site [chemical binding]; other site
718274004217	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
718274004218	putative molybdopterin cofactor binding site; other site
718274004219	tetrathionate reductase subunit C; Provisional; Region: PRK14992
718274004220	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
718274004221	tetrathionate reductase subunit B; Provisional; Region: PRK14993
718274004222	4Fe-4S binding domain; Region: Fer4; pfam00037
718274004223	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
718274004224	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
718274004225	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718274004226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274004227	dimer interface [polypeptide binding]; other site
718274004228	phosphorylation site [posttranslational modification]
718274004229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274004230	ATP binding site [chemical binding]; other site
718274004231	Mg2+ binding site [ion binding]; other site
718274004232	G-X-G motif; other site
718274004233	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
718274004234	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274004235	active site
718274004236	phosphorylation site [posttranslational modification]
718274004237	intermolecular recognition site; other site
718274004238	dimerization interface [polypeptide binding]; other site
718274004239	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274004240	DNA binding residues [nucleotide binding]
718274004241	dimerization interface [polypeptide binding]; other site
718274004242	hypothetical protein; Provisional; Region: PRK10292
718274004243	Uncharacterized conserved protein [Function unknown]; Region: COG1683
718274004244	Uncharacterized conserved protein [Function unknown]; Region: COG3272
718274004245	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
718274004246	transcriptional regulator MirA; Provisional; Region: PRK15043
718274004247	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
718274004248	DNA binding residues [nucleotide binding]
718274004249	two component system sensor kinase SsrB; Provisional; Region: PRK15369
718274004250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274004251	active site
718274004252	phosphorylation site [posttranslational modification]
718274004253	intermolecular recognition site; other site
718274004254	dimerization interface [polypeptide binding]; other site
718274004255	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274004256	DNA binding residues [nucleotide binding]
718274004257	dimerization interface [polypeptide binding]; other site
718274004258	two component system sensor kinase SsrA; Provisional; Region: PRK15347
718274004259	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274004260	dimerization interface [polypeptide binding]; other site
718274004261	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274004262	dimer interface [polypeptide binding]; other site
718274004263	phosphorylation site [posttranslational modification]
718274004264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274004265	ATP binding site [chemical binding]; other site
718274004266	Mg2+ binding site [ion binding]; other site
718274004267	G-X-G motif; other site
718274004268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274004269	active site
718274004270	phosphorylation site [posttranslational modification]
718274004271	intermolecular recognition site; other site
718274004272	dimerization interface [polypeptide binding]; other site
718274004273	pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368
718274004274	outer membrane secretin SsaC; Provisional; Region: PRK15346
718274004275	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
718274004276	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
718274004277	type III secretion system protein SsaD; Provisional; Region: PRK15367
718274004278	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
718274004279	type III secretion system chaperone SsaE; Provisional; Region: PRK15366
718274004280	type III secretion system chaperone SseA; Provisional; Region: PRK15365
718274004281	pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364
718274004282	pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363
718274004283	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
718274004284	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
718274004285	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
718274004286	type III secretion system chaperone protein SscB; Provisional; Region: PRK15359
718274004287	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718274004288	TPR motif; other site
718274004289	binding surface
718274004290	pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358
718274004291	pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357
718274004292	type III secretion system needle protein SsaG; Provisional; Region: PRK15344
718274004293	type III secretion system protein SsaH; Provisional; Region: PRK15356
718274004294	type III secretion system protein SsaI; Provisional; Region: PRK15355
718274004295	type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348
718274004296	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
718274004297	type III secretion system protein SsaK; Provisional; Region: PRK15354
718274004298	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
718274004299	type III secretion system protein SsaL; Provisional; Region: PRK15345
718274004300	HrpJ-like domain; Region: HrpJ; pfam07201
718274004301	TyeA; Region: TyeA; cl07611
718274004302	type III secretion system protein SsaM; Provisional; Region: PRK15353
718274004303	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
718274004304	FHIPEP family; Region: FHIPEP; pfam00771
718274004305	type III secretion system ATPase SsaN; Validated; Region: PRK07594
718274004306	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718274004307	Walker A motif; other site
718274004308	ATP binding site [chemical binding]; other site
718274004309	Walker B motif; other site
718274004310	type III secretion system protein SsaO; Provisional; Region: PRK15352
718274004311	type III secretion system protein SsaP; Provisional; Region: PRK15351
718274004312	type III secretion system protein SsaQ; Validated; Region: PRK08035
718274004313	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
718274004314	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
718274004315	Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790
718274004316	type III secretion system protein SsaS; Provisional; Region: PRK15350
718274004317	type III secretion system protein SsaT; Provisional; Region: PRK15349
718274004318	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
718274004319	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
718274004320	multidrug efflux protein; Reviewed; Region: PRK01766
718274004321	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
718274004322	cation binding site [ion binding]; other site
718274004323	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
718274004324	Lumazine binding domain; Region: Lum_binding; pfam00677
718274004325	Lumazine binding domain; Region: Lum_binding; pfam00677
718274004326	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
718274004327	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274004328	S-adenosylmethionine binding site [chemical binding]; other site
718274004329	putative transporter; Provisional; Region: PRK11043
718274004330	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274004331	putative substrate translocation pore; other site
718274004332	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
718274004333	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274004334	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718274004335	dimerization interface [polypeptide binding]; other site
718274004336	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
718274004337	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274004338	DNA binding site [nucleotide binding]
718274004339	domain linker motif; other site
718274004340	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
718274004341	dimerization interface [polypeptide binding]; other site
718274004342	ligand binding site [chemical binding]; other site
718274004343	superoxide dismutase; Provisional; Region: PRK10543
718274004344	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
718274004345	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
718274004346	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718274004347	NlpC/P60 family; Region: NLPC_P60; pfam00877
718274004348	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
718274004349	putative GSH binding site [chemical binding]; other site
718274004350	catalytic residues [active]
718274004351	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
718274004352	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
718274004353	dimer interface [polypeptide binding]; other site
718274004354	catalytic site [active]
718274004355	putative active site [active]
718274004356	putative substrate binding site [chemical binding]; other site
718274004357	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
718274004358	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
718274004359	dimer interface [polypeptide binding]; other site
718274004360	active site
718274004361	metal binding site [ion binding]; metal-binding site
718274004362	glutathione binding site [chemical binding]; other site
718274004363	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
718274004364	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
718274004365	FMN binding site [chemical binding]; other site
718274004366	active site
718274004367	substrate binding site [chemical binding]; other site
718274004368	catalytic residue [active]
718274004369	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
718274004370	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274004371	Predicted Fe-S protein [General function prediction only]; Region: COG3313
718274004372	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718274004373	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718274004374	active site
718274004375	catalytic tetrad [active]
718274004376	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
718274004377	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
718274004378	E-class dimer interface [polypeptide binding]; other site
718274004379	P-class dimer interface [polypeptide binding]; other site
718274004380	active site
718274004381	Cu2+ binding site [ion binding]; other site
718274004382	Zn2+ binding site [ion binding]; other site
718274004383	Fusaric acid resistance protein family; Region: FUSC; pfam04632
718274004384	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
718274004385	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
718274004386	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718274004387	HlyD family secretion protein; Region: HlyD_3; pfam13437
718274004388	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
718274004389	transcriptional regulator SlyA; Provisional; Region: PRK03573
718274004390	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
718274004391	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
718274004392	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
718274004393	lysozyme inhibitor; Provisional; Region: PRK11372
718274004394	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
718274004395	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
718274004396	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
718274004397	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
718274004398	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
718274004399	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
718274004400	active site
718274004401	HIGH motif; other site
718274004402	dimer interface [polypeptide binding]; other site
718274004403	KMSKS motif; other site
718274004404	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718274004405	RNA binding surface [nucleotide binding]; other site
718274004406	pyridoxamine kinase; Validated; Region: PRK05756
718274004407	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
718274004408	dimer interface [polypeptide binding]; other site
718274004409	pyridoxal binding site [chemical binding]; other site
718274004410	ATP binding site [chemical binding]; other site
718274004411	glutathionine S-transferase; Provisional; Region: PRK10542
718274004412	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
718274004413	C-terminal domain interface [polypeptide binding]; other site
718274004414	GSH binding site (G-site) [chemical binding]; other site
718274004415	dimer interface [polypeptide binding]; other site
718274004416	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
718274004417	dimer interface [polypeptide binding]; other site
718274004418	N-terminal domain interface [polypeptide binding]; other site
718274004419	substrate binding pocket (H-site) [chemical binding]; other site
718274004420	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
718274004421	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274004422	putative substrate translocation pore; other site
718274004423	POT family; Region: PTR2; pfam00854
718274004424	endonuclease III; Provisional; Region: PRK10702
718274004425	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
718274004426	minor groove reading motif; other site
718274004427	helix-hairpin-helix signature motif; other site
718274004428	substrate binding pocket [chemical binding]; other site
718274004429	active site
718274004430	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
718274004431	electron transport complex RsxE subunit; Provisional; Region: PRK12405
718274004432	electron transport complex protein RnfG; Validated; Region: PRK01908
718274004433	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
718274004434	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
718274004435	SLBB domain; Region: SLBB; pfam10531
718274004436	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718274004437	electron transport complex protein RnfB; Provisional; Region: PRK05113
718274004438	Putative Fe-S cluster; Region: FeS; cl17515
718274004439	4Fe-4S binding domain; Region: Fer4; pfam00037
718274004440	electron transport complex protein RsxA; Provisional; Region: PRK05151
718274004441	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
718274004442	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
718274004443	putative oxidoreductase; Provisional; Region: PRK11579
718274004444	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
718274004445	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
718274004446	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
718274004447	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
718274004448	active site
718274004449	purine riboside binding site [chemical binding]; other site
718274004450	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
718274004451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
718274004452	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
718274004453	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
718274004454	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
718274004455	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
718274004456	fumarate hydratase; Provisional; Region: PRK15389
718274004457	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
718274004458	Fumarase C-terminus; Region: Fumerase_C; pfam05683
718274004459	fumarate hydratase; Reviewed; Region: fumC; PRK00485
718274004460	Class II fumarases; Region: Fumarase_classII; cd01362
718274004461	active site
718274004462	tetramer interface [polypeptide binding]; other site
718274004463	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
718274004464	sensor protein RstB; Provisional; Region: PRK10604
718274004465	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274004466	dimerization interface [polypeptide binding]; other site
718274004467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274004468	dimer interface [polypeptide binding]; other site
718274004469	phosphorylation site [posttranslational modification]
718274004470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274004471	ATP binding site [chemical binding]; other site
718274004472	Mg2+ binding site [ion binding]; other site
718274004473	G-X-G motif; other site
718274004474	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
718274004475	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
718274004476	active site
718274004477	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
718274004478	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
718274004479	trimer interface [polypeptide binding]; other site
718274004480	eyelet of channel; other site
718274004481	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
718274004482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274004483	active site
718274004484	phosphorylation site [posttranslational modification]
718274004485	intermolecular recognition site; other site
718274004486	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274004487	DNA binding site [nucleotide binding]
718274004488	GlpM protein; Region: GlpM; pfam06942
718274004489	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
718274004490	Spore germination protein; Region: Spore_permease; cl17796
718274004491	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
718274004492	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
718274004493	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
718274004494	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
718274004495	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
718274004496	ligand binding site [chemical binding]; other site
718274004497	homodimer interface [polypeptide binding]; other site
718274004498	NAD(P) binding site [chemical binding]; other site
718274004499	trimer interface B [polypeptide binding]; other site
718274004500	trimer interface A [polypeptide binding]; other site
718274004501	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
718274004502	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
718274004503	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
718274004504	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
718274004505	Domain of unknown function DUF20; Region: UPF0118; pfam01594
718274004506	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
718274004507	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
718274004508	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
718274004509	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
718274004510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274004511	putative substrate translocation pore; other site
718274004512	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
718274004513	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274004514	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
718274004515	dimerization interface [polypeptide binding]; other site
718274004516	substrate binding pocket [chemical binding]; other site
718274004517	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
718274004518	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
718274004519	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718274004520	putative dithiobiotin synthetase; Provisional; Region: PRK12374
718274004521	AAA domain; Region: AAA_26; pfam13500
718274004522	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
718274004523	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
718274004524	Cl- selectivity filter; other site
718274004525	Cl- binding residues [ion binding]; other site
718274004526	pore gating glutamate residue; other site
718274004527	dimer interface [polypeptide binding]; other site
718274004528	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
718274004529	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
718274004530	Walker A/P-loop; other site
718274004531	ATP binding site [chemical binding]; other site
718274004532	Q-loop/lid; other site
718274004533	ABC transporter signature motif; other site
718274004534	Walker B; other site
718274004535	D-loop; other site
718274004536	H-loop/switch region; other site
718274004537	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
718274004538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274004539	dimer interface [polypeptide binding]; other site
718274004540	conserved gate region; other site
718274004541	ABC-ATPase subunit interface; other site
718274004542	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
718274004543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274004544	dimer interface [polypeptide binding]; other site
718274004545	conserved gate region; other site
718274004546	putative PBP binding loops; other site
718274004547	ABC-ATPase subunit interface; other site
718274004548	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
718274004549	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
718274004550	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
718274004551	4Fe-4S binding domain; Region: Fer4; pfam00037
718274004552	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
718274004553	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
718274004554	putative [Fe4-S4] binding site [ion binding]; other site
718274004555	putative molybdopterin cofactor binding site [chemical binding]; other site
718274004556	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
718274004557	putative molybdopterin cofactor binding site; other site
718274004558	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
718274004559	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
718274004560	putative [Fe4-S4] binding site [ion binding]; other site
718274004561	putative molybdopterin cofactor binding site [chemical binding]; other site
718274004562	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
718274004563	putative molybdopterin cofactor binding site; other site
718274004564	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
718274004565	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
718274004566	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
718274004567	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274004568	Coenzyme A binding pocket [chemical binding]; other site
718274004569	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
718274004570	hypothetical protein; Provisional; Region: PRK13659
718274004571	hypothetical protein; Provisional; Region: PRK02237
718274004572	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
718274004573	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
718274004574	putative active site pocket [active]
718274004575	putative metal binding site [ion binding]; other site
718274004576	putative oxidoreductase; Provisional; Region: PRK10083
718274004577	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
718274004578	putative NAD(P) binding site [chemical binding]; other site
718274004579	catalytic Zn binding site [ion binding]; other site
718274004580	structural Zn binding site [ion binding]; other site
718274004581	potential frameshift: common BLAST hit: gi|197249018|ref|YP_002146536.1| inner membrane metabolite transport protein YdfJ
718274004582	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274004583	putative substrate translocation pore; other site
718274004584	metabolite-proton symporter; Region: 2A0106; TIGR00883
718274004585	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
718274004586	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
718274004587	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
718274004588	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
718274004589	Transcriptional regulators [Transcription]; Region: GntR; COG1802
718274004590	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274004591	DNA-binding site [nucleotide binding]; DNA binding site
718274004592	FCD domain; Region: FCD; pfam07729
718274004593	malonic semialdehyde reductase; Provisional; Region: PRK10538
718274004594	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
718274004595	putative NAD(P) binding site [chemical binding]; other site
718274004596	homodimer interface [polypeptide binding]; other site
718274004597	homotetramer interface [polypeptide binding]; other site
718274004598	active site
718274004599	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
718274004600	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
718274004601	active site
718274004602	Zn binding site [ion binding]; other site
718274004603	General stress protein [General function prediction only]; Region: GsiB; COG3729
718274004604	hypothetical protein; Validated; Region: PRK03657
718274004605	hypothetical protein; Provisional; Region: PRK10053
718274004606	putative transporter; Provisional; Region: PRK10054
718274004607	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274004608	putative substrate translocation pore; other site
718274004609	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
718274004610	EamA-like transporter family; Region: EamA; pfam00892
718274004611	MarB protein; Region: MarB; pfam13999
718274004612	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
718274004613	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274004614	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274004615	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
718274004616	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
718274004617	inner membrane protein; Provisional; Region: PRK10995
718274004618	putative arabinose transporter; Provisional; Region: PRK03545
718274004619	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274004620	putative substrate translocation pore; other site
718274004621	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274004622	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274004623	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
718274004624	putative dimerization interface [polypeptide binding]; other site
718274004625	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
718274004626	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
718274004627	NAD(P) binding site [chemical binding]; other site
718274004628	catalytic residues [active]
718274004629	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
718274004630	glutaminase; Provisional; Region: PRK00971
718274004631	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
718274004632	Predicted membrane protein [Function unknown]; Region: COG3781
718274004633	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
718274004634	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
718274004635	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
718274004636	trimer interface [polypeptide binding]; other site
718274004637	eyelet of channel; other site
718274004638	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
718274004639	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
718274004640	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
718274004641	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
718274004642	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
718274004643	Rubredoxin [Energy production and conversion]; Region: COG1773
718274004644	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
718274004645	iron binding site [ion binding]; other site
718274004646	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
718274004647	HupF/HypC family; Region: HupF_HypC; cl00394
718274004648	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
718274004649	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
718274004650	putative substrate-binding site; other site
718274004651	nickel binding site [ion binding]; other site
718274004652	Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969
718274004653	hydrogenase 1 large subunit; Provisional; Region: PRK10170
718274004654	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
718274004655	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
718274004656	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
718274004657	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
718274004658	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
718274004659	active site
718274004660	Transcriptional regulators [Transcription]; Region: FadR; COG2186
718274004661	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274004662	DNA-binding site [nucleotide binding]; DNA binding site
718274004663	FCD domain; Region: FCD; pfam07729
718274004664	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
718274004665	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
718274004666	putative NAD(P) binding site [chemical binding]; other site
718274004667	catalytic Zn binding site [ion binding]; other site
718274004668	structural Zn binding site [ion binding]; other site
718274004669	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274004670	D-galactonate transporter; Region: 2A0114; TIGR00893
718274004671	putative substrate translocation pore; other site
718274004672	PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287
718274004673	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274004674	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718274004675	putative substrate translocation pore; other site
718274004676	hypothetical protein; Provisional; Region: PRK06184
718274004677	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
718274004678	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
718274004679	Transcriptional regulators [Transcription]; Region: MarR; COG1846
718274004680	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718274004681	putative DNA binding site [nucleotide binding]; other site
718274004682	putative Zn2+ binding site [ion binding]; other site
718274004683	S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809
718274004684	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
718274004685	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
718274004686	homotrimer interaction site [polypeptide binding]; other site
718274004687	putative active site [active]
718274004688	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
718274004689	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
718274004690	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
718274004691	Winged helix-turn helix; Region: HTH_29; pfam13551
718274004692	Helix-turn-helix domain; Region: HTH_28; pfam13518
718274004693	Homeodomain-like domain; Region: HTH_32; pfam13565
718274004694	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718274004695	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274004696	DNA binding site [nucleotide binding]
718274004697	domain linker motif; other site
718274004698	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
718274004699	dimerization interface (closed form) [polypeptide binding]; other site
718274004700	ligand binding site [chemical binding]; other site
718274004701	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
718274004702	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
718274004703	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718274004704	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274004705	homodimer interface [polypeptide binding]; other site
718274004706	catalytic residue [active]
718274004707	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
718274004708	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
718274004709	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
718274004710	active site
718274004711	catalytic site [active]
718274004712	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
718274004713	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
718274004714	active site
718274004715	catalytic site [active]
718274004716	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
718274004717	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
718274004718	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
718274004719	catalytic site [active]
718274004720	active site
718274004721	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
718274004722	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
718274004723	acid-resistance protein; Provisional; Region: hdeB; PRK11566
718274004724	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
718274004725	biofilm-dependent modulation protein; Provisional; Region: PRK11436
718274004726	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
718274004727	malate dehydrogenase; Provisional; Region: PRK13529
718274004728	Malic enzyme, N-terminal domain; Region: malic; pfam00390
718274004729	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
718274004730	NAD(P) binding site [chemical binding]; other site
718274004731	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
718274004732	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
718274004733	NAD binding site [chemical binding]; other site
718274004734	substrate binding site [chemical binding]; other site
718274004735	catalytic Zn binding site [ion binding]; other site
718274004736	tetramer interface [polypeptide binding]; other site
718274004737	structural Zn binding site [ion binding]; other site
718274004738	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
718274004739	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
718274004740	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
718274004741	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
718274004742	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
718274004743	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
718274004744	[4Fe-4S] binding site [ion binding]; other site
718274004745	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
718274004746	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
718274004747	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
718274004748	molybdopterin cofactor binding site; other site
718274004749	aromatic amino acid exporter; Provisional; Region: PRK11689
718274004750	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
718274004751	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
718274004752	trimer interface [polypeptide binding]; other site
718274004753	eyelet of channel; other site
718274004754	Uncharacterized conserved protein [Function unknown]; Region: COG3791
718274004755	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
718274004756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274004757	putative substrate translocation pore; other site
718274004758	TetR family transcriptional regulator; Provisional; Region: PRK14996
718274004759	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274004760	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
718274004761	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
718274004762	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
718274004763	[4Fe-4S] binding site [ion binding]; other site
718274004764	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
718274004765	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
718274004766	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
718274004767	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
718274004768	molybdopterin cofactor binding site; other site
718274004769	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
718274004770	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
718274004771	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
718274004772	hypothetical protein; Provisional; Region: PRK10281
718274004773	N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047
718274004774	L-asparagine permease; Provisional; Region: PRK15049
718274004775	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
718274004776	Uncharacterized conserved protein [Function unknown]; Region: COG3391
718274004777	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
718274004778	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
718274004779	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
718274004780	N-terminal plug; other site
718274004781	ligand-binding site [chemical binding]; other site
718274004782	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
718274004783	DNA-binding site [nucleotide binding]; DNA binding site
718274004784	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
718274004785	FCD domain; Region: FCD; pfam07729
718274004786	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
718274004787	Prostaglandin dehydrogenases; Region: PGDH; cd05288
718274004788	NAD(P) binding site [chemical binding]; other site
718274004789	substrate binding site [chemical binding]; other site
718274004790	dimer interface [polypeptide binding]; other site
718274004791	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
718274004792	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
718274004793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
718274004794	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
718274004795	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457
718274004796	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458
718274004797	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
718274004798	1-pyrroline dehydrogenase; Region: ABALDH; TIGR03374
718274004799	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
718274004800	tetrameric interface [polypeptide binding]; other site
718274004801	NAD binding site [chemical binding]; other site
718274004802	catalytic residues [active]
718274004803	substrate binding site [chemical binding]; other site
718274004804	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
718274004805	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274004806	DNA-binding site [nucleotide binding]; DNA binding site
718274004807	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718274004808	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274004809	homodimer interface [polypeptide binding]; other site
718274004810	catalytic residue [active]
718274004811	D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173
718274004812	secreted effector protein SifB; Provisional; Region: sifB; PRK09499
718274004813	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
718274004814	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
718274004815	Peptidase family U32; Region: Peptidase_U32; pfam01136
718274004816	Collagenase; Region: DUF3656; pfam12392
718274004817	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718274004818	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274004819	non-specific DNA binding site [nucleotide binding]; other site
718274004820	salt bridge; other site
718274004821	sequence-specific DNA binding site [nucleotide binding]; other site
718274004822	Cupin domain; Region: Cupin_2; pfam07883
718274004823	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
718274004824	benzoate transporter; Region: benE; TIGR00843
718274004825	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
718274004826	tellurite resistance protein TehB; Provisional; Region: PRK11207
718274004827	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274004828	S-adenosylmethionine binding site [chemical binding]; other site
718274004829	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
718274004830	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
718274004831	gating phenylalanine in ion channel; other site
718274004832	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
718274004833	putative trimer interface [polypeptide binding]; other site
718274004834	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
718274004835	putative trimer interface [polypeptide binding]; other site
718274004836	putative CoA binding site [chemical binding]; other site
718274004837	putative CoA binding site [chemical binding]; other site
718274004838	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
718274004839	putative trimer interface [polypeptide binding]; other site
718274004840	putative CoA binding site [chemical binding]; other site
718274004841	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
718274004842	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274004843	Coenzyme A binding pocket [chemical binding]; other site
718274004844	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
718274004845	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
718274004846	oligomer interface [polypeptide binding]; other site
718274004847	active site
718274004848	metal binding site [ion binding]; metal-binding site
718274004849	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
718274004850	active site
718274004851	P-loop; other site
718274004852	phosphorylation site [posttranslational modification]
718274004853	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
718274004854	PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827
718274004855	membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259
718274004856	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718274004857	active site
718274004858	phosphorylation site [posttranslational modification]
718274004859	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
718274004860	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
718274004861	substrate binding site [chemical binding]; other site
718274004862	hexamer interface [polypeptide binding]; other site
718274004863	metal binding site [ion binding]; metal-binding site
718274004864	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
718274004865	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
718274004866	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274004867	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
718274004868	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274004869	Coenzyme A binding pocket [chemical binding]; other site
718274004870	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
718274004871	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
718274004872	teramer interface [polypeptide binding]; other site
718274004873	active site
718274004874	FMN binding site [chemical binding]; other site
718274004875	catalytic residues [active]
718274004876	Uncharacterized conserved protein [Function unknown]; Region: COG2353
718274004877	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
718274004878	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
718274004879	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
718274004880	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
718274004881	substrate binding pocket [chemical binding]; other site
718274004882	catalytic triad [active]
718274004883	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
718274004884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
718274004885	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
718274004886	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274004887	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718274004888	dimerization interface [polypeptide binding]; other site
718274004889	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
718274004890	dimer interface [polypeptide binding]; other site
718274004891	ligand binding site [chemical binding]; other site
718274004892	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
718274004893	HAMP domain; Region: HAMP; pfam00672
718274004894	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718274004895	dimer interface [polypeptide binding]; other site
718274004896	putative CheW interface [polypeptide binding]; other site
718274004897	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
718274004898	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
718274004899	substrate binding site [chemical binding]; other site
718274004900	catalytic Zn binding site [ion binding]; other site
718274004901	NAD binding site [chemical binding]; other site
718274004902	structural Zn binding site [ion binding]; other site
718274004903	dimer interface [polypeptide binding]; other site
718274004904	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
718274004905	putative metal binding site [ion binding]; other site
718274004906	putative homodimer interface [polypeptide binding]; other site
718274004907	putative homotetramer interface [polypeptide binding]; other site
718274004908	putative homodimer-homodimer interface [polypeptide binding]; other site
718274004909	putative allosteric switch controlling residues; other site
718274004910	Sif protein; Region: Sif; cl11505
718274004911	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
718274004912	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
718274004913	active site
718274004914	catalytic triad [active]
718274004915	oxyanion hole [active]
718274004916	Predicted membrane protein [Function unknown]; Region: COG3326
718274004917	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274004918	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
718274004919	substrate binding pocket [chemical binding]; other site
718274004920	membrane-bound complex binding site; other site
718274004921	hinge residues; other site
718274004922	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718274004923	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274004924	dimer interface [polypeptide binding]; other site
718274004925	conserved gate region; other site
718274004926	putative PBP binding loops; other site
718274004927	ABC-ATPase subunit interface; other site
718274004928	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
718274004929	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274004930	Walker A/P-loop; other site
718274004931	ATP binding site [chemical binding]; other site
718274004932	Q-loop/lid; other site
718274004933	ABC transporter signature motif; other site
718274004934	Walker B; other site
718274004935	D-loop; other site
718274004936	H-loop/switch region; other site
718274004937	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718274004938	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274004939	dimer interface [polypeptide binding]; other site
718274004940	conserved gate region; other site
718274004941	putative PBP binding loops; other site
718274004942	ABC-ATPase subunit interface; other site
718274004943	Predicted membrane protein [Function unknown]; Region: COG5305
718274004944	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
718274004945	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274004946	S-adenosylmethionine binding site [chemical binding]; other site
718274004947	cytochrome b561; Provisional; Region: PRK11513
718274004948	Uncharacterized conserved protein [Function unknown]; Region: COG1434
718274004949	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
718274004950	putative active site [active]
718274004951	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
718274004952	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718274004953	ATP binding site [chemical binding]; other site
718274004954	putative Mg++ binding site [ion binding]; other site
718274004955	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274004956	nucleotide binding region [chemical binding]; other site
718274004957	ATP-binding site [chemical binding]; other site
718274004958	Helicase associated domain (HA2); Region: HA2; pfam04408
718274004959	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
718274004960	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
718274004961	azoreductase; Reviewed; Region: PRK00170
718274004962	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
718274004963	Uncharacterized conserved protein [Function unknown]; Region: COG3791
718274004964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
718274004965	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
718274004966	hypothetical protein; Provisional; Region: PRK10695
718274004967	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
718274004968	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
718274004969	putative ligand binding site [chemical binding]; other site
718274004970	putative NAD binding site [chemical binding]; other site
718274004971	catalytic site [active]
718274004972	heat-inducible protein; Provisional; Region: PRK10449
718274004973	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
718274004974	Domain of unknown function (DUF333); Region: DUF333; pfam03891
718274004975	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
718274004976	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
718274004977	dimer interface [polypeptide binding]; other site
718274004978	PYR/PP interface [polypeptide binding]; other site
718274004979	TPP binding site [chemical binding]; other site
718274004980	substrate binding site [chemical binding]; other site
718274004981	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
718274004982	Domain of unknown function; Region: EKR; smart00890
718274004983	4Fe-4S binding domain; Region: Fer4_6; pfam12837
718274004984	4Fe-4S binding domain; Region: Fer4; pfam00037
718274004985	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
718274004986	TPP-binding site [chemical binding]; other site
718274004987	dimer interface [polypeptide binding]; other site
718274004988	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
718274004989	Ligand Binding Site [chemical binding]; other site
718274004990	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
718274004991	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718274004992	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
718274004993	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
718274004994	Ligand Binding Site [chemical binding]; other site
718274004995	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
718274004996	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
718274004997	ATP binding site [chemical binding]; other site
718274004998	Mg++ binding site [ion binding]; other site
718274004999	motif III; other site
718274005000	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274005001	nucleotide binding region [chemical binding]; other site
718274005002	ATP-binding site [chemical binding]; other site
718274005003	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
718274005004	putative RNA binding site [nucleotide binding]; other site
718274005005	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
718274005006	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
718274005007	Cl binding site [ion binding]; other site
718274005008	oligomer interface [polypeptide binding]; other site
718274005009	HAMP domain; Region: HAMP; pfam00672
718274005010	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718274005011	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718274005012	dimer interface [polypeptide binding]; other site
718274005013	putative CheW interface [polypeptide binding]; other site
718274005014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
718274005015	Smr domain; Region: Smr; pfam01713
718274005016	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
718274005017	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
718274005018	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
718274005019	DNA binding site [nucleotide binding]
718274005020	active site
718274005021	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
718274005022	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
718274005023	ligand binding site [chemical binding]; other site
718274005024	flexible hinge region; other site
718274005025	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
718274005026	putative switch regulator; other site
718274005027	non-specific DNA interactions [nucleotide binding]; other site
718274005028	DNA binding site [nucleotide binding]
718274005029	sequence specific DNA binding site [nucleotide binding]; other site
718274005030	putative cAMP binding site [chemical binding]; other site
718274005031	universal stress protein UspE; Provisional; Region: PRK11175
718274005032	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
718274005033	Ligand Binding Site [chemical binding]; other site
718274005034	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
718274005035	Ligand Binding Site [chemical binding]; other site
718274005036	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
718274005037	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
718274005038	Mechanosensitive ion channel; Region: MS_channel; pfam00924
718274005039	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
718274005040	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274005041	non-specific DNA binding site [nucleotide binding]; other site
718274005042	salt bridge; other site
718274005043	sequence-specific DNA binding site [nucleotide binding]; other site
718274005044	Cupin domain; Region: Cupin_2; pfam07883
718274005045	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
718274005046	B3/4 domain; Region: B3_4; pfam03483
718274005047	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077
718274005048	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
718274005049	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
718274005050	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274005051	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
718274005052	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
718274005053	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
718274005054	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274005055	oxidoreductase; Provisional; Region: PRK12742
718274005056	classical (c) SDRs; Region: SDR_c; cd05233
718274005057	NAD(P) binding site [chemical binding]; other site
718274005058	active site
718274005059	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718274005060	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718274005061	active site
718274005062	catalytic tetrad [active]
718274005063	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274005064	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274005065	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
718274005066	putative effector binding pocket; other site
718274005067	putative dimerization interface [polypeptide binding]; other site
718274005068	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
718274005069	NmrA-like family; Region: NmrA; pfam05368
718274005070	NAD(P) binding site [chemical binding]; other site
718274005071	active site lysine
718274005072	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
718274005073	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
718274005074	peptide binding site [polypeptide binding]; other site
718274005075	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
718274005076	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
718274005077	putative active site [active]
718274005078	Zn binding site [ion binding]; other site
718274005079	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
718274005080	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
718274005081	active site
718274005082	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
718274005083	dimer interface [polypeptide binding]; other site
718274005084	catalytic triad [active]
718274005085	peroxidatic and resolving cysteines [active]
718274005086	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
718274005087	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
718274005088	putative aromatic amino acid binding site; other site
718274005089	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274005090	Walker A motif; other site
718274005091	ATP binding site [chemical binding]; other site
718274005092	Walker B motif; other site
718274005093	arginine finger; other site
718274005094	hypothetical protein; Provisional; Region: PRK05415
718274005095	TIGR01620 family protein; Region: hyp_HI0043
718274005096	Predicted ATPase [General function prediction only]; Region: COG3106
718274005097	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
718274005098	active site residue [active]
718274005099	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
718274005100	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
718274005101	phage shock protein C; Region: phageshock_pspC; TIGR02978
718274005102	phage shock protein B; Provisional; Region: pspB; PRK09458
718274005103	phage shock protein PspA; Provisional; Region: PRK10698
718274005104	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
718274005105	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274005106	Walker A motif; other site
718274005107	ATP binding site [chemical binding]; other site
718274005108	Walker B motif; other site
718274005109	arginine finger; other site
718274005110	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
718274005111	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
718274005112	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
718274005113	peptide binding site [polypeptide binding]; other site
718274005114	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
718274005115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274005116	dimer interface [polypeptide binding]; other site
718274005117	conserved gate region; other site
718274005118	putative PBP binding loops; other site
718274005119	ABC-ATPase subunit interface; other site
718274005120	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
718274005121	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
718274005122	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274005123	dimer interface [polypeptide binding]; other site
718274005124	conserved gate region; other site
718274005125	putative PBP binding loops; other site
718274005126	ABC-ATPase subunit interface; other site
718274005127	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
718274005128	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718274005129	Walker A/P-loop; other site
718274005130	ATP binding site [chemical binding]; other site
718274005131	Q-loop/lid; other site
718274005132	ABC transporter signature motif; other site
718274005133	Walker B; other site
718274005134	D-loop; other site
718274005135	H-loop/switch region; other site
718274005136	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718274005137	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
718274005138	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718274005139	Walker A/P-loop; other site
718274005140	ATP binding site [chemical binding]; other site
718274005141	Q-loop/lid; other site
718274005142	ABC transporter signature motif; other site
718274005143	Walker B; other site
718274005144	D-loop; other site
718274005145	H-loop/switch region; other site
718274005146	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
718274005147	Protein kinase domain; Region: Pkinase; pfam00069
718274005148	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
718274005149	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
718274005150	NAD binding site [chemical binding]; other site
718274005151	homotetramer interface [polypeptide binding]; other site
718274005152	homodimer interface [polypeptide binding]; other site
718274005153	substrate binding site [chemical binding]; other site
718274005154	active site
718274005155	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950
718274005156	exoribonuclease II; Provisional; Region: PRK05054
718274005157	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
718274005158	RNB domain; Region: RNB; pfam00773
718274005159	S1 RNA binding domain; Region: S1; pfam00575
718274005160	RNase II stability modulator; Provisional; Region: PRK10060
718274005161	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
718274005162	putative active site [active]
718274005163	heme pocket [chemical binding]; other site
718274005164	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718274005165	metal binding site [ion binding]; metal-binding site
718274005166	active site
718274005167	I-site; other site
718274005168	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274005169	hypothetical protein; Provisional; Region: PRK13658
718274005170	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
718274005171	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
718274005172	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274005173	lipoprotein; Provisional; Region: PRK10540
718274005174	translation initiation factor Sui1; Validated; Region: PRK06824
718274005175	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
718274005176	putative rRNA binding site [nucleotide binding]; other site
718274005177	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
718274005178	active site
718274005179	dimer interface [polypeptide binding]; other site
718274005180	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
718274005181	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718274005182	binding surface
718274005183	TPR motif; other site
718274005184	Predicted membrane protein [Function unknown]; Region: COG3771
718274005185	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
718274005186	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
718274005187	active site
718274005188	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
718274005189	dimerization interface [polypeptide binding]; other site
718274005190	active site
718274005191	aconitate hydratase; Validated; Region: PRK09277
718274005192	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
718274005193	substrate binding site [chemical binding]; other site
718274005194	ligand binding site [chemical binding]; other site
718274005195	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
718274005196	substrate binding site [chemical binding]; other site
718274005197	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
718274005198	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274005199	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
718274005200	substrate binding site [chemical binding]; other site
718274005201	putative dimerization interface [polypeptide binding]; other site
718274005202	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
718274005203	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
718274005204	active site
718274005205	interdomain interaction site; other site
718274005206	putative metal-binding site [ion binding]; other site
718274005207	nucleotide binding site [chemical binding]; other site
718274005208	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
718274005209	domain I; other site
718274005210	DNA binding groove [nucleotide binding]
718274005211	phosphate binding site [ion binding]; other site
718274005212	domain II; other site
718274005213	domain III; other site
718274005214	nucleotide binding site [chemical binding]; other site
718274005215	catalytic site [active]
718274005216	domain IV; other site
718274005217	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
718274005218	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
718274005219	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
718274005220	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
718274005221	hypothetical protein; Provisional; Region: PRK11037
718274005222	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
718274005223	putative inner membrane peptidase; Provisional; Region: PRK11778
718274005224	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
718274005225	tandem repeat interface [polypeptide binding]; other site
718274005226	oligomer interface [polypeptide binding]; other site
718274005227	active site residues [active]
718274005228	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
718274005229	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
718274005230	NADP binding site [chemical binding]; other site
718274005231	homodimer interface [polypeptide binding]; other site
718274005232	active site
718274005233	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
718274005234	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
718274005235	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
718274005236	homodimer interface [polypeptide binding]; other site
718274005237	Walker A motif; other site
718274005238	ATP binding site [chemical binding]; other site
718274005239	hydroxycobalamin binding site [chemical binding]; other site
718274005240	Walker B motif; other site
718274005241	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
718274005242	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718274005243	RNA binding surface [nucleotide binding]; other site
718274005244	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
718274005245	probable active site [active]
718274005246	hypothetical protein; Provisional; Region: PRK11630
718274005247	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
718274005248	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
718274005249	active site
718274005250	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
718274005251	anthranilate synthase component I; Provisional; Region: PRK13564
718274005252	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
718274005253	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
718274005254	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
718274005255	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
718274005256	glutamine binding [chemical binding]; other site
718274005257	catalytic triad [active]
718274005258	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
718274005259	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
718274005260	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
718274005261	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
718274005262	active site
718274005263	ribulose/triose binding site [chemical binding]; other site
718274005264	phosphate binding site [ion binding]; other site
718274005265	substrate (anthranilate) binding pocket [chemical binding]; other site
718274005266	product (indole) binding pocket [chemical binding]; other site
718274005267	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
718274005268	active site
718274005269	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
718274005270	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
718274005271	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274005272	catalytic residue [active]
718274005273	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
718274005274	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
718274005275	substrate binding site [chemical binding]; other site
718274005276	active site
718274005277	catalytic residues [active]
718274005278	heterodimer interface [polypeptide binding]; other site
718274005279	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
718274005280	dimerization interface [polypeptide binding]; other site
718274005281	metal binding site [ion binding]; metal-binding site
718274005282	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
718274005283	dinuclear metal binding motif [ion binding]; other site
718274005284	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
718274005285	dimanganese center [ion binding]; other site
718274005286	outer membrane protein W; Provisional; Region: PRK10959
718274005287	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
718274005288	hypothetical protein; Provisional; Region: PRK02868
718274005289	intracellular septation protein A; Reviewed; Region: PRK00259
718274005290	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
718274005291	transport protein TonB; Provisional; Region: PRK10819
718274005292	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
718274005293	YciI-like protein; Reviewed; Region: PRK11370
718274005294	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
718274005295	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
718274005296	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
718274005297	putative active site [active]
718274005298	catalytic site [active]
718274005299	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
718274005300	putative active site [active]
718274005301	catalytic site [active]
718274005302	dsDNA-mimic protein; Reviewed; Region: PRK05094
718274005303	Ion transport protein; Region: Ion_trans; pfam00520
718274005304	Ion channel; Region: Ion_trans_2; pfam07885
718274005305	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
718274005306	Double zinc ribbon; Region: DZR; pfam12773
718274005307	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
718274005308	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718274005309	Walker A/P-loop; other site
718274005310	ATP binding site [chemical binding]; other site
718274005311	Q-loop/lid; other site
718274005312	ABC transporter signature motif; other site
718274005313	Walker B; other site
718274005314	D-loop; other site
718274005315	H-loop/switch region; other site
718274005316	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
718274005317	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
718274005318	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718274005319	Walker A/P-loop; other site
718274005320	ATP binding site [chemical binding]; other site
718274005321	Q-loop/lid; other site
718274005322	ABC transporter signature motif; other site
718274005323	Walker B; other site
718274005324	D-loop; other site
718274005325	H-loop/switch region; other site
718274005326	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718274005327	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
718274005328	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
718274005329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274005330	dimer interface [polypeptide binding]; other site
718274005331	conserved gate region; other site
718274005332	ABC-ATPase subunit interface; other site
718274005333	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
718274005334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274005335	dimer interface [polypeptide binding]; other site
718274005336	conserved gate region; other site
718274005337	putative PBP binding loops; other site
718274005338	ABC-ATPase subunit interface; other site
718274005339	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
718274005340	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
718274005341	peptide binding site [polypeptide binding]; other site
718274005342	hypothetical protein; Provisional; Region: PRK11111
718274005343	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
718274005344	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
718274005345	putative catalytic cysteine [active]
718274005346	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
718274005347	putative active site [active]
718274005348	metal binding site [ion binding]; metal-binding site
718274005349	thymidine kinase; Provisional; Region: PRK04296
718274005350	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
718274005351	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
718274005352	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
718274005353	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
718274005354	active site
718274005355	tetramer interface; other site
718274005356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274005357	active site
718274005358	response regulator of RpoS; Provisional; Region: PRK10693
718274005359	phosphorylation site [posttranslational modification]
718274005360	intermolecular recognition site; other site
718274005361	dimerization interface [polypeptide binding]; other site
718274005362	hypothetical protein; Provisional; Region: PRK10279
718274005363	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
718274005364	active site
718274005365	nucleophile elbow; other site
718274005366	hypothetical protein; Provisional; Region: PRK01617
718274005367	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
718274005368	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
718274005369	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
718274005370	putative active site [active]
718274005371	putative substrate binding site [chemical binding]; other site
718274005372	putative cosubstrate binding site; other site
718274005373	catalytic site [active]
718274005374	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
718274005375	Sel1-like repeats; Region: SEL1; smart00671
718274005376	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
718274005377	Sel1-like repeats; Region: SEL1; smart00671
718274005378	Sel1-like repeats; Region: SEL1; smart00671
718274005379	Sel1-like repeats; Region: SEL1; smart00671
718274005380	Sel1-like repeats; Region: SEL1; smart00671
718274005381	Sel1-like repeats; Region: SEL1; smart00671
718274005382	Sel1-like repeats; Region: SEL1; smart00671
718274005383	Sel1-like repeats; Region: SEL1; smart00671
718274005384	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
718274005385	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
718274005386	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
718274005387	4Fe-4S binding domain; Region: Fer4; cl02805
718274005388	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
718274005389	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
718274005390	[4Fe-4S] binding site [ion binding]; other site
718274005391	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
718274005392	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
718274005393	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
718274005394	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
718274005395	molybdopterin cofactor binding site; other site
718274005396	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
718274005397	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
718274005398	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
718274005399	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274005400	dimerization interface [polypeptide binding]; other site
718274005401	Histidine kinase; Region: HisKA_3; pfam07730
718274005402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274005403	ATP binding site [chemical binding]; other site
718274005404	Mg2+ binding site [ion binding]; other site
718274005405	G-X-G motif; other site
718274005406	transcriptional regulator NarL; Provisional; Region: PRK10651
718274005407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274005408	active site
718274005409	phosphorylation site [posttranslational modification]
718274005410	intermolecular recognition site; other site
718274005411	dimerization interface [polypeptide binding]; other site
718274005412	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274005413	DNA binding residues [nucleotide binding]
718274005414	dimerization interface [polypeptide binding]; other site
718274005415	putative invasin; Provisional; Region: PRK10177
718274005416	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
718274005417	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
718274005418	cation transport regulator; Reviewed; Region: chaB; PRK09582
718274005419	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
718274005420	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
718274005421	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
718274005422	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
718274005423	hypothetical protein; Provisional; Region: PRK10941
718274005424	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
718274005425	hypothetical protein; Provisional; Region: PRK10278
718274005426	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
718274005427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274005428	peptide chain release factor 1; Validated; Region: prfA; PRK00591
718274005429	This domain is found in peptide chain release factors; Region: PCRF; smart00937
718274005430	RF-1 domain; Region: RF-1; pfam00472
718274005431	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
718274005432	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
718274005433	tRNA; other site
718274005434	putative tRNA binding site [nucleotide binding]; other site
718274005435	putative NADP binding site [chemical binding]; other site
718274005436	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
718274005437	Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017
718274005438	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
718274005439	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
718274005440	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
718274005441	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
718274005442	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
718274005443	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718274005444	active site
718274005445	putative transporter; Provisional; Region: PRK11660
718274005446	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
718274005447	Sulfate transporter family; Region: Sulfate_transp; pfam00916
718274005448	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
718274005449	hypothetical protein; Provisional; Region: PRK10692
718274005450	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
718274005451	putative active site [active]
718274005452	catalytic residue [active]
718274005453	GTP-binding protein YchF; Reviewed; Region: PRK09601
718274005454	YchF GTPase; Region: YchF; cd01900
718274005455	G1 box; other site
718274005456	GTP/Mg2+ binding site [chemical binding]; other site
718274005457	Switch I region; other site
718274005458	G2 box; other site
718274005459	Switch II region; other site
718274005460	G3 box; other site
718274005461	G4 box; other site
718274005462	G5 box; other site
718274005463	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
718274005464	Protein of unknown function (DUF2743); Region: DUF2743; pfam10899
718274005465	Protein of unknown function (DUF4427); Region: DUF4427; pfam14468
718274005466	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
718274005467	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
718274005468	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
718274005469	hydrogenase 1 large subunit; Provisional; Region: PRK10170
718274005470	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
718274005471	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
718274005472	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
718274005473	putative substrate-binding site; other site
718274005474	nickel binding site [ion binding]; other site
718274005475	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
718274005476	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
718274005477	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
718274005478	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
718274005479	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
718274005480	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
718274005481	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
718274005482	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
718274005483	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
718274005484	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
718274005485	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
718274005486	NAD(P) binding site [chemical binding]; other site
718274005487	trehalase; Provisional; Region: treA; PRK13271
718274005488	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
718274005489	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
718274005490	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
718274005491	Flagellar regulator YcgR; Region: YcgR; pfam07317
718274005492	PilZ domain; Region: PilZ; pfam07238
718274005493	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
718274005494	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718274005495	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718274005496	catalytic residue [active]
718274005497	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
718274005498	dimer interface [polypeptide binding]; other site
718274005499	catalytic triad [active]
718274005500	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
718274005501	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
718274005502	TrkA-C domain; Region: TrkA_C; pfam02080
718274005503	Transporter associated domain; Region: CorC_HlyC; smart01091
718274005504	alanine racemase; Reviewed; Region: dadX; PRK03646
718274005505	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
718274005506	active site
718274005507	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718274005508	substrate binding site [chemical binding]; other site
718274005509	catalytic residues [active]
718274005510	dimer interface [polypeptide binding]; other site
718274005511	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
718274005512	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
718274005513	SpoVR family protein; Provisional; Region: PRK11767
718274005514	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
718274005515	fatty acid metabolism regulator; Provisional; Region: PRK04984
718274005516	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274005517	DNA-binding site [nucleotide binding]; DNA binding site
718274005518	FadR C-terminal domain; Region: FadR_C; pfam07840
718274005519	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
718274005520	transmembrane helices; other site
718274005521	disulfide bond formation protein B; Provisional; Region: PRK01749
718274005522	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
718274005523	GnsA/GnsB family; Region: GnsAB; pfam08178
718274005524	hypothetical protein; Provisional; Region: PRK05170
718274005525	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
718274005526	hypothetical protein; Provisional; Region: PRK10691
718274005527	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
718274005528	septum formation inhibitor; Reviewed; Region: minC; PRK03511
718274005529	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
718274005530	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
718274005531	cell division inhibitor MinD; Provisional; Region: PRK10818
718274005532	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
718274005533	Switch I; other site
718274005534	Switch II; other site
718274005535	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
718274005536	ribonuclease D; Provisional; Region: PRK10829
718274005537	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
718274005538	catalytic site [active]
718274005539	putative active site [active]
718274005540	putative substrate binding site [chemical binding]; other site
718274005541	HRDC domain; Region: HRDC; cl02578
718274005542	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
718274005543	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
718274005544	acyl-activating enzyme (AAE) consensus motif; other site
718274005545	putative AMP binding site [chemical binding]; other site
718274005546	putative active site [active]
718274005547	putative CoA binding site [chemical binding]; other site
718274005548	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
718274005549	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
718274005550	Glycoprotease family; Region: Peptidase_M22; pfam00814
718274005551	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
718274005552	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
718274005553	DEAD_2; Region: DEAD_2; pfam06733
718274005554	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
718274005555	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
718274005556	homotrimer interaction site [polypeptide binding]; other site
718274005557	putative active site [active]
718274005558	hypothetical protein; Provisional; Region: PRK05114
718274005559	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
718274005560	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
718274005561	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
718274005562	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
718274005563	putative active site [active]
718274005564	putative CoA binding site [chemical binding]; other site
718274005565	nudix motif; other site
718274005566	metal binding site [ion binding]; metal-binding site
718274005567	L-serine deaminase; Provisional; Region: PRK15023
718274005568	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
718274005569	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
718274005570	phage resistance protein; Provisional; Region: PRK10551
718274005571	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
718274005572	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274005573	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
718274005574	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
718274005575	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
718274005576	Transporter associated domain; Region: CorC_HlyC; smart01091
718274005577	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
718274005578	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
718274005579	active pocket/dimerization site; other site
718274005580	active site
718274005581	phosphorylation site [posttranslational modification]
718274005582	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
718274005583	active site
718274005584	phosphorylation site [posttranslational modification]
718274005585	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
718274005586	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
718274005587	hypothetical protein; Provisional; Region: PRK02913
718274005588	hypothetical protein; Provisional; Region: PRK11469
718274005589	Domain of unknown function DUF; Region: DUF204; pfam02659
718274005590	Domain of unknown function DUF; Region: DUF204; pfam02659
718274005591	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
718274005592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274005593	S-adenosylmethionine binding site [chemical binding]; other site
718274005594	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
718274005595	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
718274005596	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
718274005597	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
718274005598	DNA-binding site [nucleotide binding]; DNA binding site
718274005599	RNA-binding motif; other site
718274005600	Protein of unknown function (DUF2627); Region: DUF2527; pfam10736
718274005601	YebO-like protein; Region: YebO; pfam13974
718274005602	PhoPQ regulatory protein; Provisional; Region: PRK10299
718274005603	YobH-like protein; Region: YobH; pfam13996
718274005604	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
718274005605	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718274005606	dimerization interface [polypeptide binding]; other site
718274005607	putative Zn2+ binding site [ion binding]; other site
718274005608	putative DNA binding site [nucleotide binding]; other site
718274005609	Bacterial transcriptional regulator; Region: IclR; pfam01614
718274005610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274005611	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718274005612	putative substrate translocation pore; other site
718274005613	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274005614	heat shock protein HtpX; Provisional; Region: PRK05457
718274005615	carboxy-terminal protease; Provisional; Region: PRK11186
718274005616	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
718274005617	protein binding site [polypeptide binding]; other site
718274005618	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
718274005619	Catalytic dyad [active]
718274005620	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
718274005621	ProP expression regulator; Provisional; Region: PRK04950
718274005622	ProQ/FINO family; Region: ProQ; pfam04352
718274005623	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
718274005624	GAF domain; Region: GAF_2; pfam13185
718274005625	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
718274005626	Paraquat-inducible protein A; Region: PqiA; pfam04403
718274005627	Paraquat-inducible protein A; Region: PqiA; pfam04403
718274005628	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
718274005629	mce related protein; Region: MCE; pfam02470
718274005630	mce related protein; Region: MCE; pfam02470
718274005631	mce related protein; Region: MCE; pfam02470
718274005632	mce related protein; Region: MCE; pfam02470
718274005633	mce related protein; Region: MCE; pfam02470
718274005634	mce related protein; Region: MCE; pfam02470
718274005635	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
718274005636	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
718274005637	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
718274005638	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
718274005639	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
718274005640	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
718274005641	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
718274005642	type III secretion protein SopE2; Provisional; Region: PRK15280
718274005643	Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364
718274005644	SopE GEF domain; Region: SopE_GEF; pfam07487
718274005645	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
718274005646	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274005647	Coenzyme A binding pocket [chemical binding]; other site
718274005648	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
718274005649	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
718274005650	MULE transposase domain; Region: MULE; pfam10551
718274005651	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718274005652	DNA binding site [nucleotide binding]
718274005653	active site
718274005654	Int/Topo IB signature motif; other site
718274005655	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
718274005656	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
718274005657	EamA-like transporter family; Region: EamA; pfam00892
718274005658	EamA-like transporter family; Region: EamA; pfam00892
718274005659	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
718274005660	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274005661	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274005662	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274005663	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
718274005664	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
718274005665	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
718274005666	exonuclease VIII; Reviewed; Region: PRK09709
718274005667	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
718274005668	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
718274005669	dimer interface [polypeptide binding]; other site
718274005670	active site
718274005671	Int/Topo IB signature motif; other site
718274005672	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
718274005673	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
718274005674	hypothetical protein; Provisional; Region: PRK10301
718274005675	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
718274005676	Predicted amidohydrolase [General function prediction only]; Region: COG0388
718274005677	Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795
718274005678	exodeoxyribonuclease X; Provisional; Region: PRK07983
718274005679	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
718274005680	active site
718274005681	catalytic site [active]
718274005682	substrate binding site [chemical binding]; other site
718274005683	protease 2; Provisional; Region: PRK10115
718274005684	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
718274005685	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
718274005686	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
718274005687	putative metal binding site [ion binding]; other site
718274005688	hypothetical protein; Provisional; Region: PRK13680
718274005689	DNA damage-inducible protein YebG; Provisional; Region: PRK10061
718274005690	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
718274005691	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718274005692	ATP-grasp domain; Region: ATP-grasp; pfam02222
718274005693	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
718274005694	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
718274005695	active site
718274005696	intersubunit interface [polypeptide binding]; other site
718274005697	catalytic residue [active]
718274005698	phosphogluconate dehydratase; Validated; Region: PRK09054
718274005699	6-phosphogluconate dehydratase; Region: edd; TIGR01196
718274005700	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
718274005701	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
718274005702	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
718274005703	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
718274005704	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
718274005705	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
718274005706	putative active site [active]
718274005707	pyruvate kinase; Provisional; Region: PRK05826
718274005708	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
718274005709	domain interfaces; other site
718274005710	active site
718274005711	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
718274005712	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
718274005713	putative acyl-acceptor binding pocket; other site
718274005714	putative peptidase; Provisional; Region: PRK11649
718274005715	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
718274005716	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718274005717	Peptidase family M23; Region: Peptidase_M23; pfam01551
718274005718	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
718274005719	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
718274005720	metal binding site [ion binding]; metal-binding site
718274005721	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
718274005722	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
718274005723	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
718274005724	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718274005725	ABC-ATPase subunit  interface; other site
718274005726	dimer interface [polypeptide binding]; other site
718274005727	putative PBP binding regions; other site
718274005728	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
718274005729	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274005730	Walker A motif; other site
718274005731	ATP binding site [chemical binding]; other site
718274005732	Walker B motif; other site
718274005733	arginine finger; other site
718274005734	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
718274005735	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
718274005736	RuvA N terminal domain; Region: RuvA_N; pfam01330
718274005737	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
718274005738	hypothetical protein; Provisional; Region: PRK11470
718274005739	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
718274005740	active site
718274005741	putative DNA-binding cleft [nucleotide binding]; other site
718274005742	dimer interface [polypeptide binding]; other site
718274005743	hypothetical protein; Validated; Region: PRK00110
718274005744	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
718274005745	nudix motif; other site
718274005746	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
718274005747	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
718274005748	dimer interface [polypeptide binding]; other site
718274005749	anticodon binding site; other site
718274005750	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
718274005751	homodimer interface [polypeptide binding]; other site
718274005752	motif 1; other site
718274005753	active site
718274005754	motif 2; other site
718274005755	GAD domain; Region: GAD; pfam02938
718274005756	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
718274005757	active site
718274005758	motif 3; other site
718274005759	Isochorismatase family; Region: Isochorismatase; pfam00857
718274005760	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
718274005761	catalytic triad [active]
718274005762	conserved cis-peptide bond; other site
718274005763	hypothetical protein; Provisional; Region: PRK10302
718274005764	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
718274005765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274005766	S-adenosylmethionine binding site [chemical binding]; other site
718274005767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274005768	S-adenosylmethionine binding site [chemical binding]; other site
718274005769	copper homeostasis protein CutC; Provisional; Region: PRK11572
718274005770	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
718274005771	putative metal binding site [ion binding]; other site
718274005772	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
718274005773	arginyl-tRNA synthetase; Region: argS; TIGR00456
718274005774	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
718274005775	active site
718274005776	HIGH motif; other site
718274005777	KMSK motif region; other site
718274005778	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
718274005779	tRNA binding surface [nucleotide binding]; other site
718274005780	anticodon binding site; other site
718274005781	penicillin-binding protein 2; Provisional; Region: PRK10795
718274005782	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
718274005783	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
718274005784	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
718274005785	Flagellar protein FlhE; Region: FlhE; pfam06366
718274005786	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
718274005787	FHIPEP family; Region: FHIPEP; pfam00771
718274005788	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
718274005789	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
718274005790	chemotaxis regulator CheZ; Provisional; Region: PRK11166
718274005791	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
718274005792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274005793	active site
718274005794	phosphorylation site [posttranslational modification]
718274005795	intermolecular recognition site; other site
718274005796	dimerization interface [polypeptide binding]; other site
718274005797	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
718274005798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274005799	active site
718274005800	phosphorylation site [posttranslational modification]
718274005801	intermolecular recognition site; other site
718274005802	dimerization interface [polypeptide binding]; other site
718274005803	CheB methylesterase; Region: CheB_methylest; pfam01339
718274005804	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
718274005805	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
718274005806	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274005807	S-adenosylmethionine binding site [chemical binding]; other site
718274005808	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
718274005809	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
718274005810	dimer interface [polypeptide binding]; other site
718274005811	ligand binding site [chemical binding]; other site
718274005812	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274005813	dimerization interface [polypeptide binding]; other site
718274005814	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718274005815	dimer interface [polypeptide binding]; other site
718274005816	putative CheW interface [polypeptide binding]; other site
718274005817	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
718274005818	putative CheA interaction surface; other site
718274005819	chemotaxis protein CheA; Provisional; Region: PRK10547
718274005820	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
718274005821	putative binding surface; other site
718274005822	active site
718274005823	CheY binding; Region: CheY-binding; pfam09078
718274005824	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
718274005825	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274005826	ATP binding site [chemical binding]; other site
718274005827	Mg2+ binding site [ion binding]; other site
718274005828	G-X-G motif; other site
718274005829	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
718274005830	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
718274005831	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
718274005832	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
718274005833	ligand binding site [chemical binding]; other site
718274005834	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
718274005835	flagellar motor protein MotA; Validated; Region: PRK09110
718274005836	transcriptional activator FlhC; Provisional; Region: PRK12722
718274005837	transcriptional activator FlhD; Provisional; Region: PRK02909
718274005838	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
718274005839	Ligand Binding Site [chemical binding]; other site
718274005840	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
718274005841	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
718274005842	active site
718274005843	homotetramer interface [polypeptide binding]; other site
718274005844	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
718274005845	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
718274005846	DJ-1 family protein; Region: not_thiJ; TIGR01383
718274005847	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
718274005848	conserved cys residue [active]
718274005849	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
718274005850	Ferritin-like domain; Region: Ferritin; pfam00210
718274005851	ferroxidase diiron center [ion binding]; other site
718274005852	hypothetical protein; Provisional; Region: PRK09273
718274005853	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
718274005854	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
718274005855	YecR-like lipoprotein; Region: YecR; pfam13992
718274005856	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
718274005857	Ferritin-like domain; Region: Ferritin; pfam00210
718274005858	ferroxidase diiron center [ion binding]; other site
718274005859	probable metal-binding protein; Region: matur_matur; TIGR03853
718274005860	tyrosine transporter TyrP; Provisional; Region: PRK15132
718274005861	aromatic amino acid transport protein; Region: araaP; TIGR00837
718274005862	hypothetical protein; Provisional; Region: PRK10396
718274005863	yecA family protein; Region: ygfB_yecA; TIGR02292
718274005864	SEC-C motif; Region: SEC-C; pfam02810
718274005865	glucose-6-phosphate 1-dehydrogenase; Region: PLN02640
718274005866	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
718274005867	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
718274005868	NlpC/P60 family; Region: NLPC_P60; cl17555
718274005869	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
718274005870	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
718274005871	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
718274005872	GIY-YIG motif/motif A; other site
718274005873	active site
718274005874	catalytic site [active]
718274005875	putative DNA binding site [nucleotide binding]; other site
718274005876	metal binding site [ion binding]; metal-binding site
718274005877	UvrB/uvrC motif; Region: UVR; pfam02151
718274005878	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
718274005879	Helix-hairpin-helix motif; Region: HHH; pfam00633
718274005880	response regulator; Provisional; Region: PRK09483
718274005881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274005882	active site
718274005883	phosphorylation site [posttranslational modification]
718274005884	intermolecular recognition site; other site
718274005885	dimerization interface [polypeptide binding]; other site
718274005886	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274005887	DNA binding residues [nucleotide binding]
718274005888	dimerization interface [polypeptide binding]; other site
718274005889	hypothetical protein; Provisional; Region: PRK10613
718274005890	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
718274005891	Autoinducer binding domain; Region: Autoind_bind; pfam03472
718274005892	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274005893	DNA binding residues [nucleotide binding]
718274005894	dimerization interface [polypeptide binding]; other site
718274005895	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
718274005896	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
718274005897	Walker A/P-loop; other site
718274005898	ATP binding site [chemical binding]; other site
718274005899	Q-loop/lid; other site
718274005900	ABC transporter signature motif; other site
718274005901	Walker B; other site
718274005902	D-loop; other site
718274005903	H-loop/switch region; other site
718274005904	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
718274005905	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718274005906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274005907	dimer interface [polypeptide binding]; other site
718274005908	conserved gate region; other site
718274005909	putative PBP binding loops; other site
718274005910	ABC-ATPase subunit interface; other site
718274005911	D-cysteine desulfhydrase; Validated; Region: PRK03910
718274005912	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
718274005913	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274005914	catalytic residue [active]
718274005915	cystine transporter subunit; Provisional; Region: PRK11260
718274005916	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274005917	substrate binding pocket [chemical binding]; other site
718274005918	membrane-bound complex binding site; other site
718274005919	hinge residues; other site
718274005920	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
718274005921	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
718274005922	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718274005923	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
718274005924	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718274005925	DNA binding residues [nucleotide binding]
718274005926	Transposase IS200 like; Region: Y1_Tnp; pfam01797
718274005927	flagellin; Validated; Region: PRK08026
718274005928	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
718274005929	Flagellin D3 domain; Region: Flagellin_D3; pfam08884
718274005930	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
718274005931	flagellar capping protein; Reviewed; Region: fliD; PRK08032
718274005932	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
718274005933	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
718274005934	flagellar protein FliS; Validated; Region: fliS; PRK05685
718274005935	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
718274005936	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
718274005937	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
718274005938	active site
718274005939	Na/Ca binding site [ion binding]; other site
718274005940	catalytic site [active]
718274005941	lipoprotein; Provisional; Region: PRK10397
718274005942	putative inner membrane protein; Provisional; Region: PRK11099
718274005943	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
718274005944	CPxP  motif; other site
718274005945	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
718274005946	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
718274005947	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
718274005948	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
718274005949	flagellar motor switch protein FliG; Region: fliG; TIGR00207
718274005950	FliG C-terminal domain; Region: FliG_C; pfam01706
718274005951	flagellar assembly protein H; Validated; Region: fliH; PRK05687
718274005952	Flagellar assembly protein FliH; Region: FliH; pfam02108
718274005953	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
718274005954	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
718274005955	Walker A motif/ATP binding site; other site
718274005956	Walker B motif; other site
718274005957	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
718274005958	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
718274005959	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
718274005960	flagellar hook-length control protein; Provisional; Region: PRK10118
718274005961	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
718274005962	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
718274005963	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
718274005964	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
718274005965	flagellar motor switch protein; Validated; Region: fliN; PRK05698
718274005966	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
718274005967	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
718274005968	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
718274005969	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
718274005970	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
718274005971	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274005972	DNA binding residues [nucleotide binding]
718274005973	dimerization interface [polypeptide binding]; other site
718274005974	hypothetical protein; Provisional; Region: PRK10708
718274005975	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
718274005976	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
718274005977	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274005978	active site
718274005979	motif I; other site
718274005980	motif II; other site
718274005981	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
718274005982	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718274005983	metal binding site [ion binding]; metal-binding site
718274005984	active site
718274005985	I-site; other site
718274005986	Uncharacterized small protein [Function unknown]; Region: COG5475
718274005987	hypothetical protein; Provisional; Region: PRK10062
718274005988	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
718274005989	EamA-like transporter family; Region: EamA; pfam00892
718274005990	EamA-like transporter family; Region: EamA; pfam00892
718274005991	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
718274005992	additional DNA contacts [nucleotide binding]; other site
718274005993	mismatch recognition site; other site
718274005994	active site
718274005995	zinc binding site [ion binding]; other site
718274005996	DNA intercalation site [nucleotide binding]; other site
718274005997	DNA cytosine methylase; Provisional; Region: PRK10458
718274005998	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
718274005999	cofactor binding site; other site
718274006000	DNA binding site [nucleotide binding]
718274006001	substrate interaction site [chemical binding]; other site
718274006002	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
718274006003	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718274006004	Zn2+ binding site [ion binding]; other site
718274006005	Mg2+ binding site [ion binding]; other site
718274006006	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
718274006007	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
718274006008	trimer interface [polypeptide binding]; other site
718274006009	eyelet of channel; other site
718274006010	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
718274006011	DNA-binding site [nucleotide binding]; DNA binding site
718274006012	RNA-binding motif; other site
718274006013	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
718274006014	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
718274006015	active site
718274006016	DNA binding site [nucleotide binding]
718274006017	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
718274006018	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
718274006019	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
718274006020	Catalytic site [active]
718274006021	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
718274006022	potential frameshift: common BLAST hit: gi|205353129|ref|YP_002226930.1| phage integrase
718274006023	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
718274006024	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718274006025	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
718274006026	putative protease; Region: PHA00666
718274006027	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
718274006028	Integrase; Region: Integrase_1; pfam12835
718274006029	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
718274006030	DDE superfamily endonuclease; Region: DDE_3; pfam13358
718274006031	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
718274006032	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
718274006033	Sel1 repeat; Region: Sel1; pfam08238
718274006034	Sel1-like repeats; Region: SEL1; smart00671
718274006035	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
718274006036	AMP nucleosidase; Provisional; Region: PRK08292
718274006037	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
718274006038	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
718274006039	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
718274006040	MATE family multidrug exporter; Provisional; Region: PRK10189
718274006041	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
718274006042	L,D-transpeptidase; Provisional; Region: PRK10190
718274006043	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
718274006044	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
718274006045	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
718274006046	putative dimer interface [polypeptide binding]; other site
718274006047	active site pocket [active]
718274006048	putative cataytic base [active]
718274006049	cobalamin synthase; Reviewed; Region: cobS; PRK00235
718274006050	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
718274006051	homotrimer interface [polypeptide binding]; other site
718274006052	Walker A motif; other site
718274006053	GTP binding site [chemical binding]; other site
718274006054	Walker B motif; other site
718274006055	cobyric acid synthase; Provisional; Region: PRK00784
718274006056	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
718274006057	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
718274006058	catalytic triad [active]
718274006059	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
718274006060	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
718274006061	Walker A/P-loop; other site
718274006062	ATP binding site [chemical binding]; other site
718274006063	Q-loop/lid; other site
718274006064	ABC transporter signature motif; other site
718274006065	Walker B; other site
718274006066	D-loop; other site
718274006067	H-loop/switch region; other site
718274006068	cobalt transport protein CbiQ; Provisional; Region: PRK15485
718274006069	cobalt transport protein CbiN; Provisional; Region: PRK02898
718274006070	cobalt transport protein CbiM; Validated; Region: PRK08319
718274006071	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
718274006072	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
718274006073	active site
718274006074	SAM binding site [chemical binding]; other site
718274006075	homodimer interface [polypeptide binding]; other site
718274006076	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
718274006077	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
718274006078	active site
718274006079	C-terminal domain interface [polypeptide binding]; other site
718274006080	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
718274006081	active site
718274006082	N-terminal domain interface [polypeptide binding]; other site
718274006083	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
718274006084	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
718274006085	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
718274006086	active site
718274006087	SAM binding site [chemical binding]; other site
718274006088	homodimer interface [polypeptide binding]; other site
718274006089	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
718274006090	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
718274006091	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
718274006092	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
718274006093	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
718274006094	active site
718274006095	SAM binding site [chemical binding]; other site
718274006096	homodimer interface [polypeptide binding]; other site
718274006097	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
718274006098	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274006099	S-adenosylmethionine binding site [chemical binding]; other site
718274006100	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
718274006101	active site
718274006102	putative homodimer interface [polypeptide binding]; other site
718274006103	SAM binding site [chemical binding]; other site
718274006104	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
718274006105	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
718274006106	Precorrin-8X methylmutase; Region: CbiC; pfam02570
718274006107	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
718274006108	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
718274006109	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
718274006110	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
718274006111	catalytic triad [active]
718274006112	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
718274006113	Sensory domain found in PocR; Region: PocR; pfam10114
718274006114	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274006115	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718274006116	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274006117	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
718274006118	amphipathic channel; other site
718274006119	Asn-Pro-Ala signature motifs; other site
718274006120	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
718274006121	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
718274006122	Hexamer interface [polypeptide binding]; other site
718274006123	Putative hexagonal pore residue; other site
718274006124	propanediol utilization protein PduB; Provisional; Region: PRK15415
718274006125	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
718274006126	putative hexamer interface [polypeptide binding]; other site
718274006127	putative hexagonal pore; other site
718274006128	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
718274006129	putative hexamer interface [polypeptide binding]; other site
718274006130	putative hexagonal pore; other site
718274006131	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
718274006132	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
718274006133	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
718274006134	alpha-beta subunit interface [polypeptide binding]; other site
718274006135	alpha-gamma subunit interface [polypeptide binding]; other site
718274006136	active site
718274006137	substrate and K+ binding site; other site
718274006138	K+ binding site [ion binding]; other site
718274006139	cobalamin binding site [chemical binding]; other site
718274006140	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
718274006141	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
718274006142	Cell division protein FtsA; Region: FtsA; cl17206
718274006143	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
718274006144	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
718274006145	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
718274006146	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
718274006147	Hexamer interface [polypeptide binding]; other site
718274006148	Putative hexagonal pore residue; other site
718274006149	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
718274006150	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
718274006151	putative hexamer interface [polypeptide binding]; other site
718274006152	putative hexagonal pore; other site
718274006153	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
718274006154	Propanediol utilisation protein PduL; Region: PduL; pfam06130
718274006155	Propanediol utilisation protein PduL; Region: PduL; pfam06130
718274006156	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
718274006157	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
718274006158	Hexamer/Pentamer interface [polypeptide binding]; other site
718274006159	central pore; other site
718274006160	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
718274006161	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
718274006162	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
718274006163	putative catalytic cysteine [active]
718274006164	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
718274006165	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
718274006166	putative active site [active]
718274006167	metal binding site [ion binding]; metal-binding site
718274006168	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
718274006169	SLBB domain; Region: SLBB; pfam10531
718274006170	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
718274006171	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
718274006172	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
718274006173	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
718274006174	putative hexamer interface [polypeptide binding]; other site
718274006175	putative hexagonal pore; other site
718274006176	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
718274006177	putative hexamer interface [polypeptide binding]; other site
718274006178	putative hexagonal pore; other site
718274006179	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
718274006180	putative hexamer interface [polypeptide binding]; other site
718274006181	putative hexagonal pore; other site
718274006182	Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662
718274006183	G3 box; other site
718274006184	Switch II region; other site
718274006185	GTP/Mg2+ binding site [chemical binding]; other site
718274006186	G4 box; other site
718274006187	G5 box; other site
718274006188	propionate kinase; Reviewed; Region: PRK12397
718274006189	propionate/acetate kinase; Provisional; Region: PRK12379
718274006190	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
718274006191	hypothetical protein; Provisional; Region: PRK05423
718274006192	Predicted membrane protein [Function unknown]; Region: COG1289
718274006193	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
718274006194	DNA gyrase inhibitor; Provisional; Region: PRK10016
718274006195	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
718274006196	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
718274006197	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
718274006198	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
718274006199	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
718274006200	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
718274006201	4Fe-4S binding domain; Region: Fer4; cl02805
718274006202	thiosulfate reductase PhsA; Provisional; Region: PRK15488
718274006203	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
718274006204	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
718274006205	putative [Fe4-S4] binding site [ion binding]; other site
718274006206	putative molybdopterin cofactor binding site [chemical binding]; other site
718274006207	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
718274006208	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
718274006209	putative molybdopterin cofactor binding site; other site
718274006210	E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377
718274006211	SopA-like central domain; Region: SopA; pfam13981
718274006212	SopA-like catalytic domain; Region: SopA_C; pfam13979
718274006213	exonuclease I; Provisional; Region: sbcB; PRK11779
718274006214	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
718274006215	active site
718274006216	catalytic site [active]
718274006217	substrate binding site [chemical binding]; other site
718274006218	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
718274006219	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
718274006220	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274006221	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
718274006222	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718274006223	dimerization interface [polypeptide binding]; other site
718274006224	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
718274006225	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
718274006226	putative NAD(P) binding site [chemical binding]; other site
718274006227	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
718274006228	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
718274006229	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
718274006230	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
718274006231	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
718274006232	NAD binding site [chemical binding]; other site
718274006233	dimerization interface [polypeptide binding]; other site
718274006234	product binding site; other site
718274006235	substrate binding site [chemical binding]; other site
718274006236	zinc binding site [ion binding]; other site
718274006237	catalytic residues [active]
718274006238	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
718274006239	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718274006240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274006241	homodimer interface [polypeptide binding]; other site
718274006242	catalytic residue [active]
718274006243	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
718274006244	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274006245	active site
718274006246	motif I; other site
718274006247	motif II; other site
718274006248	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
718274006249	putative active site pocket [active]
718274006250	4-fold oligomerization interface [polypeptide binding]; other site
718274006251	metal binding residues [ion binding]; metal-binding site
718274006252	3-fold/trimer interface [polypeptide binding]; other site
718274006253	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
718274006254	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
718274006255	putative active site [active]
718274006256	oxyanion strand; other site
718274006257	catalytic triad [active]
718274006258	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
718274006259	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
718274006260	catalytic residues [active]
718274006261	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
718274006262	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
718274006263	substrate binding site [chemical binding]; other site
718274006264	glutamase interaction surface [polypeptide binding]; other site
718274006265	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
718274006266	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
718274006267	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
718274006268	metal binding site [ion binding]; metal-binding site
718274006269	chain length determinant protein WzzB; Provisional; Region: PRK15471
718274006270	Chain length determinant protein; Region: Wzz; pfam02706
718274006271	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
718274006272	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
718274006273	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
718274006274	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
718274006275	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
718274006276	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
718274006277	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
718274006278	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
718274006279	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
718274006280	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
718274006281	Bacterial sugar transferase; Region: Bac_transf; pfam02397
718274006282	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
718274006283	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
718274006284	active site
718274006285	substrate binding site [chemical binding]; other site
718274006286	metal binding site [ion binding]; metal-binding site
718274006287	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
718274006288	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
718274006289	Substrate binding site; other site
718274006290	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
718274006291	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
718274006292	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
718274006293	active site
718274006294	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718274006295	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718274006296	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
718274006297	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
718274006298	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
718274006299	active site
718274006300	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
718274006301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
718274006302	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
718274006303	NAD(P) binding site [chemical binding]; other site
718274006304	active site
718274006305	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
718274006306	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
718274006307	inhibitor-cofactor binding pocket; inhibition site
718274006308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274006309	catalytic residue [active]
718274006310	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
718274006311	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
718274006312	NAD binding site [chemical binding]; other site
718274006313	homotetramer interface [polypeptide binding]; other site
718274006314	homodimer interface [polypeptide binding]; other site
718274006315	substrate binding site [chemical binding]; other site
718274006316	active site
718274006317	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
718274006318	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
718274006319	substrate binding site; other site
718274006320	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
718274006321	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
718274006322	catalytic loop [active]
718274006323	iron binding site [ion binding]; other site
718274006324	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
718274006325	FAD binding pocket [chemical binding]; other site
718274006326	FAD binding motif [chemical binding]; other site
718274006327	phosphate binding motif [ion binding]; other site
718274006328	beta-alpha-beta structure motif; other site
718274006329	NAD binding pocket [chemical binding]; other site
718274006330	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
718274006331	glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480
718274006332	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
718274006333	substrate binding site; other site
718274006334	tetramer interface; other site
718274006335	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
718274006336	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
718274006337	NADP binding site [chemical binding]; other site
718274006338	active site
718274006339	putative substrate binding site [chemical binding]; other site
718274006340	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
718274006341	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
718274006342	NAD binding site [chemical binding]; other site
718274006343	substrate binding site [chemical binding]; other site
718274006344	homodimer interface [polypeptide binding]; other site
718274006345	active site
718274006346	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
718274006347	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
718274006348	active site
718274006349	tetramer interface; other site
718274006350	colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004
718274006351	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
718274006352	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
718274006353	putative ADP-binding pocket [chemical binding]; other site
718274006354	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
718274006355	colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006
718274006356	colanic acid exporter; Provisional; Region: PRK10459
718274006357	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
718274006358	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
718274006359	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
718274006360	phosphomannomutase CpsG; Provisional; Region: PRK15414
718274006361	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
718274006362	active site
718274006363	substrate binding site [chemical binding]; other site
718274006364	metal binding site [ion binding]; metal-binding site
718274006365	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
718274006366	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
718274006367	Substrate binding site; other site
718274006368	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
718274006369	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
718274006370	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
718274006371	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
718274006372	active site
718274006373	GDP-Mannose binding site [chemical binding]; other site
718274006374	dimer interface [polypeptide binding]; other site
718274006375	modified nudix motif
718274006376	metal binding site [ion binding]; metal-binding site
718274006377	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
718274006378	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
718274006379	NADP binding site [chemical binding]; other site
718274006380	active site
718274006381	putative substrate binding site [chemical binding]; other site
718274006382	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
718274006383	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
718274006384	NADP-binding site; other site
718274006385	homotetramer interface [polypeptide binding]; other site
718274006386	substrate binding site [chemical binding]; other site
718274006387	homodimer interface [polypeptide binding]; other site
718274006388	active site
718274006389	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
718274006390	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
718274006391	putative trimer interface [polypeptide binding]; other site
718274006392	putative active site [active]
718274006393	putative substrate binding site [chemical binding]; other site
718274006394	putative CoA binding site [chemical binding]; other site
718274006395	putative glycosyl transferase; Provisional; Region: PRK10063
718274006396	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
718274006397	metal-binding site
718274006398	putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075
718274006399	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
718274006400	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
718274006401	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
718274006402	putative acyl transferase; Provisional; Region: PRK10191
718274006403	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
718274006404	trimer interface [polypeptide binding]; other site
718274006405	active site
718274006406	substrate binding site [chemical binding]; other site
718274006407	CoA binding site [chemical binding]; other site
718274006408	putative glycosyl transferase; Provisional; Region: PRK10018
718274006409	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
718274006410	active site
718274006411	tyrosine kinase; Provisional; Region: PRK11519
718274006412	Chain length determinant protein; Region: Wzz; pfam02706
718274006413	Chain length determinant protein; Region: Wzz; cl15801
718274006414	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
718274006415	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
718274006416	Low molecular weight phosphatase family; Region: LMWPc; cd00115
718274006417	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
718274006418	active site
718274006419	polysaccharide export protein Wza; Provisional; Region: PRK15078
718274006420	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
718274006421	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
718274006422	FOG: CBS domain [General function prediction only]; Region: COG0517
718274006423	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
718274006424	Transporter associated domain; Region: CorC_HlyC; smart01091
718274006425	putative assembly protein; Provisional; Region: PRK10833
718274006426	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
718274006427	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
718274006428	trimer interface [polypeptide binding]; other site
718274006429	active site
718274006430	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
718274006431	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
718274006432	ATP-binding site [chemical binding]; other site
718274006433	Sugar specificity; other site
718274006434	Pyrimidine base specificity; other site
718274006435	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
718274006436	PAS domain S-box; Region: sensory_box; TIGR00229
718274006437	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
718274006438	putative active site [active]
718274006439	heme pocket [chemical binding]; other site
718274006440	PAS domain S-box; Region: sensory_box; TIGR00229
718274006441	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
718274006442	putative active site [active]
718274006443	heme pocket [chemical binding]; other site
718274006444	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718274006445	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718274006446	metal binding site [ion binding]; metal-binding site
718274006447	active site
718274006448	I-site; other site
718274006449	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274006450	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
718274006451	AlkA N-terminal domain; Region: AlkA_N; pfam06029
718274006452	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
718274006453	minor groove reading motif; other site
718274006454	helix-hairpin-helix signature motif; other site
718274006455	substrate binding pocket [chemical binding]; other site
718274006456	active site
718274006457	putative chaperone; Provisional; Region: PRK11678
718274006458	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
718274006459	nucleotide binding site [chemical binding]; other site
718274006460	putative NEF/HSP70 interaction site [polypeptide binding]; other site
718274006461	SBD interface [polypeptide binding]; other site
718274006462	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
718274006463	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718274006464	HlyD family secretion protein; Region: HlyD_3; pfam13437
718274006465	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
718274006466	Protein export membrane protein; Region: SecD_SecF; cl14618
718274006467	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
718274006468	putative transporter; Provisional; Region: PRK10504
718274006469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274006470	putative substrate translocation pore; other site
718274006471	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
718274006472	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274006473	dimerization interface [polypeptide binding]; other site
718274006474	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274006475	dimer interface [polypeptide binding]; other site
718274006476	phosphorylation site [posttranslational modification]
718274006477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274006478	ATP binding site [chemical binding]; other site
718274006479	Mg2+ binding site [ion binding]; other site
718274006480	G-X-G motif; other site
718274006481	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
718274006482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274006483	active site
718274006484	phosphorylation site [posttranslational modification]
718274006485	intermolecular recognition site; other site
718274006486	dimerization interface [polypeptide binding]; other site
718274006487	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274006488	DNA binding site [nucleotide binding]
718274006489	PcfJ-like protein; Region: PcfJ; pfam14284
718274006490	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
718274006491	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
718274006492	putative protease; Provisional; Region: PRK15452
718274006493	Peptidase family U32; Region: Peptidase_U32; pfam01136
718274006494	type III secretion system protein; Provisional; Region: PRK15384; cl14665
718274006495	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
718274006496	lipid kinase; Reviewed; Region: PRK13054
718274006497	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
718274006498	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
718274006499	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
718274006500	putative active site; other site
718274006501	catalytic residue [active]
718274006502	nucleoside transporter; Region: 2A0110; TIGR00889
718274006503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274006504	putative substrate translocation pore; other site
718274006505	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
718274006506	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718274006507	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
718274006508	substrate binding site [chemical binding]; other site
718274006509	ATP binding site [chemical binding]; other site
718274006510	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
718274006511	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274006512	DNA-binding site [nucleotide binding]; DNA binding site
718274006513	UTRA domain; Region: UTRA; pfam07702
718274006514	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
718274006515	dimer interface [polypeptide binding]; other site
718274006516	substrate binding site [chemical binding]; other site
718274006517	ATP binding site [chemical binding]; other site
718274006518	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
718274006519	substrate binding site [chemical binding]; other site
718274006520	multimerization interface [polypeptide binding]; other site
718274006521	ATP binding site [chemical binding]; other site
718274006522	Predicted integral membrane protein [Function unknown]; Region: COG5455
718274006523	putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216
718274006524	putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252
718274006525	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
718274006526	PapC N-terminal domain; Region: PapC_N; pfam13954
718274006527	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
718274006528	PapC C-terminal domain; Region: PapC_C; pfam13953
718274006529	fimbrial chaperone protein PegB; Provisional; Region: PRK15218
718274006530	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274006531	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274006532	fimbrial chaperone protein; Provisional; Region: PRK15220
718274006533	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
718274006534	antiporter inner membrane protein; Provisional; Region: PRK11670
718274006535	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
718274006536	Walker A motif; other site
718274006537	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
718274006538	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
718274006539	active site
718274006540	HIGH motif; other site
718274006541	KMSKS motif; other site
718274006542	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
718274006543	tRNA binding surface [nucleotide binding]; other site
718274006544	anticodon binding site; other site
718274006545	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
718274006546	dimer interface [polypeptide binding]; other site
718274006547	putative tRNA-binding site [nucleotide binding]; other site
718274006548	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
718274006549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
718274006550	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
718274006551	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
718274006552	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
718274006553	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
718274006554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274006555	active site
718274006556	phosphorylation site [posttranslational modification]
718274006557	intermolecular recognition site; other site
718274006558	dimerization interface [polypeptide binding]; other site
718274006559	LytTr DNA-binding domain; Region: LytTR; pfam04397
718274006560	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
718274006561	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
718274006562	GAF domain; Region: GAF; pfam01590
718274006563	Histidine kinase; Region: His_kinase; pfam06580
718274006564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274006565	ATP binding site [chemical binding]; other site
718274006566	Mg2+ binding site [ion binding]; other site
718274006567	G-X-G motif; other site
718274006568	transcriptional regulator MirA; Provisional; Region: PRK15043
718274006569	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
718274006570	DNA binding residues [nucleotide binding]
718274006571	hypothetical protein; Provisional; Region: PRK13681
718274006572	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
718274006573	putative PBP binding loops; other site
718274006574	ABC-ATPase subunit interface; other site
718274006575	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
718274006576	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
718274006577	Walker A/P-loop; other site
718274006578	ATP binding site [chemical binding]; other site
718274006579	Q-loop/lid; other site
718274006580	ABC transporter signature motif; other site
718274006581	Walker B; other site
718274006582	D-loop; other site
718274006583	H-loop/switch region; other site
718274006584	CBS domain; Region: CBS; pfam00571
718274006585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274006586	dimer interface [polypeptide binding]; other site
718274006587	conserved gate region; other site
718274006588	ABC-ATPase subunit interface; other site
718274006589	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
718274006590	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
718274006591	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
718274006592	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
718274006593	D-lactate dehydrogenase; Provisional; Region: PRK11183
718274006594	FAD binding domain; Region: FAD_binding_4; pfam01565
718274006595	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
718274006596	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
718274006597	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
718274006598	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
718274006599	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
718274006600	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
718274006601	oxidoreductase; Provisional; Region: PRK12743
718274006602	classical (c) SDRs; Region: SDR_c; cd05233
718274006603	NAD(P) binding site [chemical binding]; other site
718274006604	active site
718274006605	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
718274006606	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
718274006607	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
718274006608	FMN binding site [chemical binding]; other site
718274006609	active site
718274006610	catalytic residues [active]
718274006611	substrate binding site [chemical binding]; other site
718274006612	salicylate hydroxylase; Provisional; Region: PRK08163
718274006613	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
718274006614	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
718274006615	maleylacetoacetate isomerase; Region: maiA; TIGR01262
718274006616	C-terminal domain interface [polypeptide binding]; other site
718274006617	GSH binding site (G-site) [chemical binding]; other site
718274006618	putative dimer interface [polypeptide binding]; other site
718274006619	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
718274006620	dimer interface [polypeptide binding]; other site
718274006621	N-terminal domain interface [polypeptide binding]; other site
718274006622	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
718274006623	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
718274006624	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
718274006625	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
718274006626	Cupin domain; Region: Cupin_2; pfam07883
718274006627	Cupin domain; Region: Cupin_2; pfam07883
718274006628	benzoate transport; Region: 2A0115; TIGR00895
718274006629	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274006630	putative substrate translocation pore; other site
718274006631	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
718274006632	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274006633	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718274006634	dimerization interface [polypeptide binding]; other site
718274006635	hypothetical protein; Provisional; Region: PRK01821
718274006636	hypothetical protein; Provisional; Region: PRK10711
718274006637	cytidine deaminase; Provisional; Region: PRK09027
718274006638	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
718274006639	active site
718274006640	catalytic motif [active]
718274006641	Zn binding site [ion binding]; other site
718274006642	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
718274006643	active site
718274006644	catalytic motif [active]
718274006645	Zn binding site [ion binding]; other site
718274006646	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
718274006647	putative active site [active]
718274006648	Protein of unknown function (DUF2542); Region: DUF2542; pfam10808
718274006649	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
718274006650	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718274006651	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274006652	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
718274006653	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
718274006654	homodimer interface [polypeptide binding]; other site
718274006655	active site
718274006656	FMN binding site [chemical binding]; other site
718274006657	substrate binding site [chemical binding]; other site
718274006658	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718274006659	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
718274006660	TM-ABC transporter signature motif; other site
718274006661	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
718274006662	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
718274006663	Walker A/P-loop; other site
718274006664	ATP binding site [chemical binding]; other site
718274006665	Q-loop/lid; other site
718274006666	ABC transporter signature motif; other site
718274006667	Walker B; other site
718274006668	D-loop; other site
718274006669	H-loop/switch region; other site
718274006670	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
718274006671	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
718274006672	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
718274006673	ligand binding site [chemical binding]; other site
718274006674	calcium binding site [ion binding]; other site
718274006675	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
718274006676	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274006677	DNA binding site [nucleotide binding]
718274006678	domain linker motif; other site
718274006679	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
718274006680	dimerization interface (closed form) [polypeptide binding]; other site
718274006681	ligand binding site [chemical binding]; other site
718274006682	Predicted membrane protein [Function unknown]; Region: COG2311
718274006683	hypothetical protein; Provisional; Region: PRK10835
718274006684	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
718274006685	GTP cyclohydrolase I; Provisional; Region: PLN03044
718274006686	active site
718274006687	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
718274006688	S-formylglutathione hydrolase; Region: PLN02442
718274006689	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274006690	non-specific DNA binding site [nucleotide binding]; other site
718274006691	salt bridge; other site
718274006692	sequence-specific DNA binding site [nucleotide binding]; other site
718274006693	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
718274006694	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
718274006695	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
718274006696	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
718274006697	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
718274006698	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274006699	motif II; other site
718274006700	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
718274006701	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274006702	putative substrate translocation pore; other site
718274006703	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
718274006704	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
718274006705	N-terminal plug; other site
718274006706	ligand-binding site [chemical binding]; other site
718274006707	lysine transporter; Provisional; Region: PRK10836
718274006708	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
718274006709	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274006710	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
718274006711	putative dimerization interface [polypeptide binding]; other site
718274006712	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
718274006713	endonuclease IV; Provisional; Region: PRK01060
718274006714	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
718274006715	AP (apurinic/apyrimidinic) site pocket; other site
718274006716	DNA interaction; other site
718274006717	Metal-binding active site; metal-binding site
718274006718	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
718274006719	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
718274006720	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
718274006721	active site
718274006722	P-loop; other site
718274006723	phosphorylation site [posttranslational modification]
718274006724	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
718274006725	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
718274006726	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
718274006727	putative substrate binding site [chemical binding]; other site
718274006728	putative ATP binding site [chemical binding]; other site
718274006729	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
718274006730	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718274006731	active site
718274006732	phosphorylation site [posttranslational modification]
718274006733	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718274006734	dimerization domain swap beta strand [polypeptide binding]; other site
718274006735	regulatory protein interface [polypeptide binding]; other site
718274006736	active site
718274006737	regulatory phosphorylation site [posttranslational modification]; other site
718274006738	sugar efflux transporter B; Provisional; Region: PRK15011
718274006739	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274006740	putative substrate translocation pore; other site
718274006741	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
718274006742	Flagellin N-methylase; Region: FliB; cl00497
718274006743	elongation factor P; Provisional; Region: PRK04542
718274006744	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
718274006745	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
718274006746	RNA binding site [nucleotide binding]; other site
718274006747	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
718274006748	RNA binding site [nucleotide binding]; other site
718274006749	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
718274006750	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
718274006751	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
718274006752	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
718274006753	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
718274006754	active site
718274006755	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
718274006756	NlpC/P60 family; Region: NLPC_P60; pfam00877
718274006757	phage resistance protein; Provisional; Region: PRK10551
718274006758	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
718274006759	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274006760	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
718274006761	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
718274006762	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
718274006763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274006764	dimer interface [polypeptide binding]; other site
718274006765	conserved gate region; other site
718274006766	putative PBP binding loops; other site
718274006767	ABC-ATPase subunit interface; other site
718274006768	microcin C ABC transporter permease; Provisional; Region: PRK15021
718274006769	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274006770	dimer interface [polypeptide binding]; other site
718274006771	conserved gate region; other site
718274006772	ABC-ATPase subunit interface; other site
718274006773	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
718274006774	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718274006775	Walker A/P-loop; other site
718274006776	ATP binding site [chemical binding]; other site
718274006777	Q-loop/lid; other site
718274006778	ABC transporter signature motif; other site
718274006779	Walker B; other site
718274006780	D-loop; other site
718274006781	H-loop/switch region; other site
718274006782	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
718274006783	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718274006784	Walker A/P-loop; other site
718274006785	ATP binding site [chemical binding]; other site
718274006786	Q-loop/lid; other site
718274006787	ABC transporter signature motif; other site
718274006788	Walker B; other site
718274006789	D-loop; other site
718274006790	H-loop/switch region; other site
718274006791	hypothetical protein; Provisional; Region: PRK11835
718274006792	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274006793	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
718274006794	putative substrate translocation pore; other site
718274006795	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
718274006796	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718274006797	RNA binding surface [nucleotide binding]; other site
718274006798	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
718274006799	active site
718274006800	uracil binding [chemical binding]; other site
718274006801	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
718274006802	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718274006803	ATP binding site [chemical binding]; other site
718274006804	putative Mg++ binding site [ion binding]; other site
718274006805	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274006806	nucleotide binding region [chemical binding]; other site
718274006807	ATP-binding site [chemical binding]; other site
718274006808	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
718274006809	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
718274006810	5S rRNA interface [nucleotide binding]; other site
718274006811	CTC domain interface [polypeptide binding]; other site
718274006812	L16 interface [polypeptide binding]; other site
718274006813	Nucleoid-associated protein [General function prediction only]; Region: COG3081
718274006814	nucleoid-associated protein NdpA; Validated; Region: PRK00378
718274006815	hypothetical protein; Provisional; Region: PRK13689
718274006816	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
718274006817	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
718274006818	Sulfatase; Region: Sulfatase; cl17466
718274006819	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
718274006820	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
718274006821	Catalytic site [active]
718274006822	DinI-like family; Region: DinI; cl11630
718274006823	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
718274006824	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
718274006825	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
718274006826	Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903
718274006827	Phage head maturation protease [General function prediction only]; Region: COG3740
718274006828	Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938
718274006829	Phage-related protein [Function unknown]; Region: COG4695; cl01923
718274006830	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
718274006831	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
718274006832	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
718274006833	Protein of unknown function (DUF968); Region: DUF968; pfam06147
718274006834	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
718274006835	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
718274006836	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
718274006837	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
718274006838	Leucine-rich repeats; other site
718274006839	Substrate binding site [chemical binding]; other site
718274006840	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
718274006841	DinI-like family; Region: DinI; cl11630
718274006842	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
718274006843	transcriptional regulator NarP; Provisional; Region: PRK10403
718274006844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274006845	active site
718274006846	phosphorylation site [posttranslational modification]
718274006847	intermolecular recognition site; other site
718274006848	dimerization interface [polypeptide binding]; other site
718274006849	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274006850	DNA binding residues [nucleotide binding]
718274006851	dimerization interface [polypeptide binding]; other site
718274006852	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
718274006853	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
718274006854	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
718274006855	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
718274006856	catalytic residues [active]
718274006857	central insert; other site
718274006858	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
718274006859	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
718274006860	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
718274006861	heme exporter protein CcmC; Region: ccmC; TIGR01191
718274006862	heme exporter protein CcmB; Region: ccmB; TIGR01190
718274006863	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
718274006864	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274006865	Walker A/P-loop; other site
718274006866	ATP binding site [chemical binding]; other site
718274006867	Q-loop/lid; other site
718274006868	ABC transporter signature motif; other site
718274006869	Walker B; other site
718274006870	D-loop; other site
718274006871	H-loop/switch region; other site
718274006872	cytochrome c-type protein NapC; Provisional; Region: PRK10617
718274006873	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
718274006874	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
718274006875	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
718274006876	4Fe-4S binding domain; Region: Fer4_5; pfam12801
718274006877	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718274006878	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
718274006879	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
718274006880	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
718274006881	[4Fe-4S] binding site [ion binding]; other site
718274006882	molybdopterin cofactor binding site; other site
718274006883	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
718274006884	molybdopterin cofactor binding site; other site
718274006885	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
718274006886	ferredoxin-type protein; Provisional; Region: PRK10194
718274006887	4Fe-4S binding domain; Region: Fer4; cl02805
718274006888	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
718274006889	secondary substrate binding site; other site
718274006890	primary substrate binding site; other site
718274006891	inhibition loop; other site
718274006892	dimerization interface [polypeptide binding]; other site
718274006893	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
718274006894	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
718274006895	Walker A/P-loop; other site
718274006896	ATP binding site [chemical binding]; other site
718274006897	Q-loop/lid; other site
718274006898	ABC transporter signature motif; other site
718274006899	Walker B; other site
718274006900	D-loop; other site
718274006901	H-loop/switch region; other site
718274006902	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
718274006903	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
718274006904	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
718274006905	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274006906	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
718274006907	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
718274006908	DNA binding site [nucleotide binding]
718274006909	active site
718274006910	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
718274006911	ApbE family; Region: ApbE; pfam02424
718274006912	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
718274006913	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
718274006914	trimer interface [polypeptide binding]; other site
718274006915	eyelet of channel; other site
718274006916	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
718274006917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274006918	ATP binding site [chemical binding]; other site
718274006919	G-X-G motif; other site
718274006920	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
718274006921	putative binding surface; other site
718274006922	active site
718274006923	transcriptional regulator RcsB; Provisional; Region: PRK10840
718274006924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274006925	active site
718274006926	phosphorylation site [posttranslational modification]
718274006927	intermolecular recognition site; other site
718274006928	dimerization interface [polypeptide binding]; other site
718274006929	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274006930	DNA binding residues [nucleotide binding]
718274006931	dimerization interface [polypeptide binding]; other site
718274006932	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
718274006933	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274006934	dimer interface [polypeptide binding]; other site
718274006935	phosphorylation site [posttranslational modification]
718274006936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274006937	ATP binding site [chemical binding]; other site
718274006938	Mg2+ binding site [ion binding]; other site
718274006939	G-X-G motif; other site
718274006940	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
718274006941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274006942	active site
718274006943	phosphorylation site [posttranslational modification]
718274006944	intermolecular recognition site; other site
718274006945	dimerization interface [polypeptide binding]; other site
718274006946	DNA gyrase subunit A; Validated; Region: PRK05560
718274006947	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
718274006948	CAP-like domain; other site
718274006949	active site
718274006950	primary dimer interface [polypeptide binding]; other site
718274006951	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718274006952	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718274006953	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718274006954	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718274006955	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718274006956	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718274006957	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
718274006958	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
718274006959	active site pocket [active]
718274006960	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
718274006961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274006962	putative substrate translocation pore; other site
718274006963	Transcriptional regulators [Transcription]; Region: GntR; COG1802
718274006964	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274006965	DNA-binding site [nucleotide binding]; DNA binding site
718274006966	FCD domain; Region: FCD; pfam07729
718274006967	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
718274006968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274006969	S-adenosylmethionine binding site [chemical binding]; other site
718274006970	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
718274006971	ATP cone domain; Region: ATP-cone; pfam03477
718274006972	Class I ribonucleotide reductase; Region: RNR_I; cd01679
718274006973	active site
718274006974	dimer interface [polypeptide binding]; other site
718274006975	catalytic residues [active]
718274006976	effector binding site; other site
718274006977	R2 peptide binding site; other site
718274006978	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
718274006979	dimer interface [polypeptide binding]; other site
718274006980	putative radical transfer pathway; other site
718274006981	diiron center [ion binding]; other site
718274006982	tyrosyl radical; other site
718274006983	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
718274006984	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
718274006985	catalytic loop [active]
718274006986	iron binding site [ion binding]; other site
718274006987	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718274006988	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274006989	putative substrate translocation pore; other site
718274006990	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
718274006991	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274006992	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718274006993	dimerization interface [polypeptide binding]; other site
718274006994	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
718274006995	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
718274006996	active site
718274006997	catalytic site [active]
718274006998	metal binding site [ion binding]; metal-binding site
718274006999	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
718274007000	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274007001	putative substrate translocation pore; other site
718274007002	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
718274007003	hydroxyglutarate oxidase; Provisional; Region: PRK11728
718274007004	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
718274007005	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
718274007006	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
718274007007	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
718274007008	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718274007009	Cysteine-rich domain; Region: CCG; pfam02754
718274007010	Cysteine-rich domain; Region: CCG; pfam02754
718274007011	deubiquitinase SseL; Provisional; Region: PRK14848
718274007012	hypothetical protein; Provisional; Region: PRK03673
718274007013	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
718274007014	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274007015	D-galactonate transporter; Region: 2A0114; TIGR00893
718274007016	putative substrate translocation pore; other site
718274007017	L-rhamnonate dehydratase; Provisional; Region: PRK15440
718274007018	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
718274007019	putative active site pocket [active]
718274007020	putative metal binding site [ion binding]; other site
718274007021	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
718274007022	Transcriptional regulator [Transcription]; Region: IclR; COG1414
718274007023	Bacterial transcriptional regulator; Region: IclR; pfam01614
718274007024	hypothetical protein; Provisional; Region: PRK03673
718274007025	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
718274007026	putative MPT binding site; other site
718274007027	Competence-damaged protein; Region: CinA; cl00666
718274007028	YfaZ precursor; Region: YfaZ; pfam07437
718274007029	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
718274007030	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
718274007031	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
718274007032	catalytic core [active]
718274007033	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
718274007034	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
718274007035	inhibitor-cofactor binding pocket; inhibition site
718274007036	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274007037	catalytic residue [active]
718274007038	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
718274007039	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
718274007040	Ligand binding site; other site
718274007041	Putative Catalytic site; other site
718274007042	DXD motif; other site
718274007043	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
718274007044	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
718274007045	active site
718274007046	substrate binding site [chemical binding]; other site
718274007047	cosubstrate binding site; other site
718274007048	catalytic site [active]
718274007049	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
718274007050	active site
718274007051	hexamer interface [polypeptide binding]; other site
718274007052	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
718274007053	NAD binding site [chemical binding]; other site
718274007054	substrate binding site [chemical binding]; other site
718274007055	active site
718274007056	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
718274007057	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
718274007058	putative active site [active]
718274007059	putative catalytic site [active]
718274007060	putative Zn binding site [ion binding]; other site
718274007061	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
718274007062	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
718274007063	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
718274007064	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
718274007065	signal transduction protein PmrD; Provisional; Region: PRK15450
718274007066	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
718274007067	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
718274007068	acyl-activating enzyme (AAE) consensus motif; other site
718274007069	putative AMP binding site [chemical binding]; other site
718274007070	putative active site [active]
718274007071	putative CoA binding site [chemical binding]; other site
718274007072	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
718274007073	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
718274007074	active site
718274007075	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
718274007076	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
718274007077	substrate binding site [chemical binding]; other site
718274007078	oxyanion hole (OAH) forming residues; other site
718274007079	trimer interface [polypeptide binding]; other site
718274007080	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
718274007081	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
718274007082	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
718274007083	dimer interface [polypeptide binding]; other site
718274007084	tetramer interface [polypeptide binding]; other site
718274007085	PYR/PP interface [polypeptide binding]; other site
718274007086	TPP binding site [chemical binding]; other site
718274007087	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
718274007088	TPP-binding site; other site
718274007089	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
718274007090	isochorismate synthases; Region: isochor_syn; TIGR00543
718274007091	hypothetical protein; Provisional; Region: PRK10404
718274007092	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274007093	Coenzyme A binding pocket [chemical binding]; other site
718274007094	ribonuclease BN; Region: true_RNase_BN; TIGR02649
718274007095	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
718274007096	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
718274007097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274007098	active site
718274007099	phosphorylation site [posttranslational modification]
718274007100	intermolecular recognition site; other site
718274007101	dimerization interface [polypeptide binding]; other site
718274007102	von Willebrand factor; Region: vWF_A; pfam12450
718274007103	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
718274007104	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
718274007105	metal ion-dependent adhesion site (MIDAS); other site
718274007106	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
718274007107	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
718274007108	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
718274007109	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
718274007110	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
718274007111	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
718274007112	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
718274007113	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
718274007114	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
718274007115	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
718274007116	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
718274007117	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
718274007118	4Fe-4S binding domain; Region: Fer4; pfam00037
718274007119	4Fe-4S binding domain; Region: Fer4; pfam00037
718274007120	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
718274007121	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
718274007122	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
718274007123	catalytic loop [active]
718274007124	iron binding site [ion binding]; other site
718274007125	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
718274007126	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
718274007127	[4Fe-4S] binding site [ion binding]; other site
718274007128	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
718274007129	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
718274007130	SLBB domain; Region: SLBB; pfam10531
718274007131	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
718274007132	NADH dehydrogenase subunit E; Validated; Region: PRK07539
718274007133	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
718274007134	putative dimer interface [polypeptide binding]; other site
718274007135	[2Fe-2S] cluster binding site [ion binding]; other site
718274007136	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
718274007137	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
718274007138	NADH dehydrogenase subunit D; Validated; Region: PRK06075
718274007139	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
718274007140	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
718274007141	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
718274007142	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274007143	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
718274007144	putative dimerization interface [polypeptide binding]; other site
718274007145	aminotransferase AlaT; Validated; Region: PRK09265
718274007146	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718274007147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274007148	homodimer interface [polypeptide binding]; other site
718274007149	catalytic residue [active]
718274007150	5'-nucleotidase; Provisional; Region: PRK03826
718274007151	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
718274007152	transmembrane helices; other site
718274007153	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
718274007154	TrkA-C domain; Region: TrkA_C; pfam02080
718274007155	TrkA-C domain; Region: TrkA_C; pfam02080
718274007156	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
718274007157	putative phosphatase; Provisional; Region: PRK11587
718274007158	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274007159	motif II; other site
718274007160	hypothetical protein; Validated; Region: PRK05445
718274007161	hypothetical protein; Provisional; Region: PRK01816
718274007162	propionate/acetate kinase; Provisional; Region: PRK12379
718274007163	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
718274007164	phosphate acetyltransferase; Reviewed; Region: PRK05632
718274007165	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
718274007166	DRTGG domain; Region: DRTGG; pfam07085
718274007167	phosphate acetyltransferase; Region: pta; TIGR00651
718274007168	hypothetical protein; Provisional; Region: PRK11588
718274007169	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
718274007170	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
718274007171	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
718274007172	PYR/PP interface [polypeptide binding]; other site
718274007173	dimer interface [polypeptide binding]; other site
718274007174	TPP binding site [chemical binding]; other site
718274007175	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
718274007176	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
718274007177	TPP-binding site [chemical binding]; other site
718274007178	dimer interface [polypeptide binding]; other site
718274007179	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996
718274007180	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
718274007181	active site
718274007182	P-loop; other site
718274007183	phosphorylation site [posttranslational modification]
718274007184	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718274007185	active site
718274007186	phosphorylation site [posttranslational modification]
718274007187	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718274007188	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274007189	DNA binding site [nucleotide binding]
718274007190	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
718274007191	putative dimerization interface [polypeptide binding]; other site
718274007192	putative ligand binding site [chemical binding]; other site
718274007193	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
718274007194	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
718274007195	nudix motif; other site
718274007196	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
718274007197	active site
718274007198	metal binding site [ion binding]; metal-binding site
718274007199	homotetramer interface [polypeptide binding]; other site
718274007200	glutathione S-transferase; Provisional; Region: PRK15113
718274007201	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
718274007202	C-terminal domain interface [polypeptide binding]; other site
718274007203	GSH binding site (G-site) [chemical binding]; other site
718274007204	dimer interface [polypeptide binding]; other site
718274007205	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
718274007206	N-terminal domain interface [polypeptide binding]; other site
718274007207	putative dimer interface [polypeptide binding]; other site
718274007208	putative substrate binding pocket (H-site) [chemical binding]; other site
718274007209	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
718274007210	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
718274007211	C-terminal domain interface [polypeptide binding]; other site
718274007212	GSH binding site (G-site) [chemical binding]; other site
718274007213	dimer interface [polypeptide binding]; other site
718274007214	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
718274007215	N-terminal domain interface [polypeptide binding]; other site
718274007216	putative dimer interface [polypeptide binding]; other site
718274007217	active site
718274007218	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
718274007219	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
718274007220	putative NAD(P) binding site [chemical binding]; other site
718274007221	putative active site [active]
718274007222	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
718274007223	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
718274007224	Walker A/P-loop; other site
718274007225	ATP binding site [chemical binding]; other site
718274007226	Q-loop/lid; other site
718274007227	ABC transporter signature motif; other site
718274007228	Walker B; other site
718274007229	D-loop; other site
718274007230	H-loop/switch region; other site
718274007231	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718274007232	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274007233	dimer interface [polypeptide binding]; other site
718274007234	conserved gate region; other site
718274007235	putative PBP binding loops; other site
718274007236	ABC-ATPase subunit interface; other site
718274007237	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
718274007238	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274007239	dimer interface [polypeptide binding]; other site
718274007240	conserved gate region; other site
718274007241	putative PBP binding loops; other site
718274007242	ABC-ATPase subunit interface; other site
718274007243	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
718274007244	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274007245	substrate binding pocket [chemical binding]; other site
718274007246	membrane-bound complex binding site; other site
718274007247	hinge residues; other site
718274007248	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
718274007249	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274007250	substrate binding pocket [chemical binding]; other site
718274007251	membrane-bound complex binding site; other site
718274007252	hinge residues; other site
718274007253	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
718274007254	Flavoprotein; Region: Flavoprotein; pfam02441
718274007255	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
718274007256	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
718274007257	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
718274007258	dimer interface [polypeptide binding]; other site
718274007259	active site
718274007260	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718274007261	substrate binding site [chemical binding]; other site
718274007262	catalytic residue [active]
718274007263	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
718274007264	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
718274007265	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
718274007266	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718274007267	catalytic residue [active]
718274007268	PAS fold; Region: PAS_4; pfam08448
718274007269	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
718274007270	putative active site [active]
718274007271	heme pocket [chemical binding]; other site
718274007272	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
718274007273	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274007274	Walker A motif; other site
718274007275	ATP binding site [chemical binding]; other site
718274007276	Walker B motif; other site
718274007277	arginine finger; other site
718274007278	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
718274007279	amidophosphoribosyltransferase; Provisional; Region: PRK09246
718274007280	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
718274007281	active site
718274007282	tetramer interface [polypeptide binding]; other site
718274007283	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718274007284	active site
718274007285	colicin V production protein; Provisional; Region: PRK10845
718274007286	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
718274007287	cell division protein DedD; Provisional; Region: PRK11633
718274007288	Sporulation related domain; Region: SPOR; pfam05036
718274007289	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
718274007290	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718274007291	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718274007292	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
718274007293	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
718274007294	hypothetical protein; Provisional; Region: PRK10847
718274007295	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
718274007296	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
718274007297	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
718274007298	dimerization interface 3.5A [polypeptide binding]; other site
718274007299	active site
718274007300	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
718274007301	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
718274007302	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
718274007303	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
718274007304	ligand binding site [chemical binding]; other site
718274007305	NAD binding site [chemical binding]; other site
718274007306	catalytic site [active]
718274007307	homodimer interface [polypeptide binding]; other site
718274007308	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
718274007309	putative transporter; Provisional; Region: PRK12382
718274007310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274007311	putative substrate translocation pore; other site
718274007312	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274007313	non-specific DNA binding site [nucleotide binding]; other site
718274007314	salt bridge; other site
718274007315	sequence-specific DNA binding site [nucleotide binding]; other site
718274007316	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
718274007317	CAAX protease self-immunity; Region: Abi; pfam02517
718274007318	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
718274007319	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
718274007320	dimer interface [polypeptide binding]; other site
718274007321	active site
718274007322	Uncharacterized conserved protein [Function unknown]; Region: COG4121
718274007323	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
718274007324	YfcL protein; Region: YfcL; pfam08891
718274007325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
718274007326	hypothetical protein; Provisional; Region: PRK10621
718274007327	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
718274007328	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
718274007329	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
718274007330	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
718274007331	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
718274007332	Tetramer interface [polypeptide binding]; other site
718274007333	active site
718274007334	FMN-binding site [chemical binding]; other site
718274007335	HemK family putative methylases; Region: hemK_fam; TIGR00536
718274007336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274007337	S-adenosylmethionine binding site [chemical binding]; other site
718274007338	hypothetical protein; Provisional; Region: PRK04946
718274007339	Smr domain; Region: Smr; pfam01713
718274007340	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718274007341	catalytic core [active]
718274007342	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
718274007343	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
718274007344	substrate binding site [chemical binding]; other site
718274007345	oxyanion hole (OAH) forming residues; other site
718274007346	trimer interface [polypeptide binding]; other site
718274007347	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
718274007348	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
718274007349	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
718274007350	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
718274007351	dimer interface [polypeptide binding]; other site
718274007352	active site
718274007353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
718274007354	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
718274007355	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
718274007356	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
718274007357	outer membrane protease; Reviewed; Region: PRK10993
718274007358	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
718274007359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274007360	active site
718274007361	phosphorylation site [posttranslational modification]
718274007362	intermolecular recognition site; other site
718274007363	dimerization interface [polypeptide binding]; other site
718274007364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
718274007365	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
718274007366	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
718274007367	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
718274007368	dimerization interface [polypeptide binding]; other site
718274007369	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274007370	dimer interface [polypeptide binding]; other site
718274007371	phosphorylation site [posttranslational modification]
718274007372	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274007373	ATP binding site [chemical binding]; other site
718274007374	Mg2+ binding site [ion binding]; other site
718274007375	G-X-G motif; other site
718274007376	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
718274007377	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
718274007378	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
718274007379	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274007380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274007381	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
718274007382	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
718274007383	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
718274007384	putative acyl-acceptor binding pocket; other site
718274007385	aminotransferase; Validated; Region: PRK08175
718274007386	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718274007387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274007388	homodimer interface [polypeptide binding]; other site
718274007389	catalytic residue [active]
718274007390	glucokinase; Provisional; Region: glk; PRK00292
718274007391	glucokinase, proteobacterial type; Region: glk; TIGR00749
718274007392	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
718274007393	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
718274007394	Cl- selectivity filter; other site
718274007395	Cl- binding residues [ion binding]; other site
718274007396	pore gating glutamate residue; other site
718274007397	dimer interface [polypeptide binding]; other site
718274007398	indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393
718274007399	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
718274007400	dimer interface [polypeptide binding]; other site
718274007401	PYR/PP interface [polypeptide binding]; other site
718274007402	TPP binding site [chemical binding]; other site
718274007403	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
718274007404	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
718274007405	TPP-binding site [chemical binding]; other site
718274007406	dimer interface [polypeptide binding]; other site
718274007407	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718274007408	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718274007409	active site
718274007410	catalytic tetrad [active]
718274007411	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
718274007412	manganese transport protein MntH; Reviewed; Region: PRK00701
718274007413	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
718274007414	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
718274007415	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
718274007416	Nucleoside recognition; Region: Gate; pfam07670
718274007417	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
718274007418	MASE1; Region: MASE1; pfam05231
718274007419	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718274007420	diguanylate cyclase; Region: GGDEF; smart00267
718274007421	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274007422	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
718274007423	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
718274007424	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
718274007425	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
718274007426	active site
718274007427	HIGH motif; other site
718274007428	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
718274007429	active site
718274007430	KMSKS motif; other site
718274007431	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
718274007432	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274007433	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
718274007434	putative dimerization interface [polypeptide binding]; other site
718274007435	putative substrate binding pocket [chemical binding]; other site
718274007436	XapX domain; Region: XapX; TIGR03510
718274007437	nucleoside transporter; Region: 2A0110; TIGR00889
718274007438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274007439	putative substrate translocation pore; other site
718274007440	purine nucleoside phosphorylase; Provisional; Region: PRK08202
718274007441	hypothetical protein; Provisional; Region: PRK11528
718274007442	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274007443	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274007444	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
718274007445	putative dimerization interface [polypeptide binding]; other site
718274007446	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
718274007447	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
718274007448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
718274007449	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
718274007450	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
718274007451	nucleotide binding pocket [chemical binding]; other site
718274007452	K-X-D-G motif; other site
718274007453	catalytic site [active]
718274007454	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
718274007455	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
718274007456	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
718274007457	Dimer interface [polypeptide binding]; other site
718274007458	BRCT sequence motif; other site
718274007459	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
718274007460	cell division protein ZipA; Provisional; Region: PRK03427
718274007461	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
718274007462	FtsZ protein binding site [polypeptide binding]; other site
718274007463	putative sulfate transport protein CysZ; Validated; Region: PRK04949
718274007464	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
718274007465	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
718274007466	dimer interface [polypeptide binding]; other site
718274007467	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274007468	catalytic residue [active]
718274007469	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718274007470	dimerization domain swap beta strand [polypeptide binding]; other site
718274007471	regulatory protein interface [polypeptide binding]; other site
718274007472	active site
718274007473	regulatory phosphorylation site [posttranslational modification]; other site
718274007474	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
718274007475	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
718274007476	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
718274007477	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
718274007478	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
718274007479	HPr interaction site; other site
718274007480	glycerol kinase (GK) interaction site [polypeptide binding]; other site
718274007481	active site
718274007482	phosphorylation site [posttranslational modification]
718274007483	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
718274007484	dimer interface [polypeptide binding]; other site
718274007485	pyridoxamine kinase; Validated; Region: PRK05756
718274007486	pyridoxal binding site [chemical binding]; other site
718274007487	ATP binding site [chemical binding]; other site
718274007488	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
718274007489	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274007490	DNA-binding site [nucleotide binding]; DNA binding site
718274007491	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718274007492	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274007493	homodimer interface [polypeptide binding]; other site
718274007494	catalytic residue [active]
718274007495	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
718274007496	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
718274007497	catalytic triad [active]
718274007498	hypothetical protein; Provisional; Region: PRK10318
718274007499	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
718274007500	Transglycosylase; Region: Transgly; cl17702
718274007501	cysteine synthase B; Region: cysM; TIGR01138
718274007502	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
718274007503	dimer interface [polypeptide binding]; other site
718274007504	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274007505	catalytic residue [active]
718274007506	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
718274007507	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
718274007508	Walker A/P-loop; other site
718274007509	ATP binding site [chemical binding]; other site
718274007510	Q-loop/lid; other site
718274007511	ABC transporter signature motif; other site
718274007512	Walker B; other site
718274007513	D-loop; other site
718274007514	H-loop/switch region; other site
718274007515	TOBE-like domain; Region: TOBE_3; pfam12857
718274007516	sulfate transport protein; Provisional; Region: cysT; CHL00187
718274007517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274007518	dimer interface [polypeptide binding]; other site
718274007519	conserved gate region; other site
718274007520	putative PBP binding loops; other site
718274007521	ABC-ATPase subunit interface; other site
718274007522	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
718274007523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274007524	dimer interface [polypeptide binding]; other site
718274007525	conserved gate region; other site
718274007526	putative PBP binding loops; other site
718274007527	ABC-ATPase subunit interface; other site
718274007528	thiosulfate transporter subunit; Provisional; Region: PRK10852
718274007529	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
718274007530	short chain dehydrogenase; Provisional; Region: PRK08226
718274007531	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
718274007532	NAD binding site [chemical binding]; other site
718274007533	homotetramer interface [polypeptide binding]; other site
718274007534	homodimer interface [polypeptide binding]; other site
718274007535	active site
718274007536	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
718274007537	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
718274007538	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
718274007539	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
718274007540	putative acetyltransferase; Provisional; Region: PRK03624
718274007541	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274007542	Coenzyme A binding pocket [chemical binding]; other site
718274007543	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
718274007544	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
718274007545	active site
718274007546	metal binding site [ion binding]; metal-binding site
718274007547	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
718274007548	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
718274007549	transcriptional regulator EutR; Provisional; Region: PRK10130
718274007550	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274007551	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274007552	carboxysome structural protein EutK; Provisional; Region: PRK15466
718274007553	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
718274007554	Hexamer interface [polypeptide binding]; other site
718274007555	Hexagonal pore residue; other site
718274007556	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
718274007557	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
718274007558	putative hexamer interface [polypeptide binding]; other site
718274007559	putative hexagonal pore; other site
718274007560	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
718274007561	putative hexamer interface [polypeptide binding]; other site
718274007562	putative hexagonal pore; other site
718274007563	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
718274007564	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
718274007565	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
718274007566	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
718274007567	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
718274007568	ethanol dehydrogenase EutG; Provisional; Region: PRK15454
718274007569	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
718274007570	active site
718274007571	metal binding site [ion binding]; metal-binding site
718274007572	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
718274007573	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718274007574	nucleotide binding site [chemical binding]; other site
718274007575	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
718274007576	putative catalytic cysteine [active]
718274007577	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
718274007578	Hexamer/Pentamer interface [polypeptide binding]; other site
718274007579	central pore; other site
718274007580	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
718274007581	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
718274007582	Hexamer interface [polypeptide binding]; other site
718274007583	Putative hexagonal pore residue; other site
718274007584	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
718274007585	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
718274007586	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
718274007587	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766
718274007588	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
718274007589	G1 box; other site
718274007590	GTP/Mg2+ binding site [chemical binding]; other site
718274007591	G2 box; other site
718274007592	Switch I region; other site
718274007593	G3 box; other site
718274007594	Switch II region; other site
718274007595	G4 box; other site
718274007596	G5 box; other site
718274007597	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
718274007598	putative hexamer interface [polypeptide binding]; other site
718274007599	putative hexagonal pore; other site
718274007600	Transposase IS200 like; Region: Y1_Tnp; pfam01797
718274007601	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
718274007602	Malic enzyme, N-terminal domain; Region: malic; pfam00390
718274007603	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
718274007604	putative NAD(P) binding site [chemical binding]; other site
718274007605	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
718274007606	transaldolase-like protein; Provisional; Region: PTZ00411
718274007607	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
718274007608	active site
718274007609	dimer interface [polypeptide binding]; other site
718274007610	catalytic residue [active]
718274007611	transketolase; Reviewed; Region: PRK12753
718274007612	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
718274007613	TPP-binding site [chemical binding]; other site
718274007614	dimer interface [polypeptide binding]; other site
718274007615	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
718274007616	PYR/PP interface [polypeptide binding]; other site
718274007617	dimer interface [polypeptide binding]; other site
718274007618	TPP binding site [chemical binding]; other site
718274007619	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
718274007620	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
718274007621	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
718274007622	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
718274007623	dimer interface [polypeptide binding]; other site
718274007624	ADP-ribose binding site [chemical binding]; other site
718274007625	active site
718274007626	nudix motif; other site
718274007627	metal binding site [ion binding]; metal-binding site
718274007628	putative periplasmic esterase; Provisional; Region: PRK03642
718274007629	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
718274007630	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
718274007631	4Fe-4S binding domain; Region: Fer4; pfam00037
718274007632	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
718274007633	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274007634	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
718274007635	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
718274007636	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274007637	dimerization interface [polypeptide binding]; other site
718274007638	Histidine kinase; Region: HisKA_3; pfam07730
718274007639	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274007640	ATP binding site [chemical binding]; other site
718274007641	Mg2+ binding site [ion binding]; other site
718274007642	G-X-G motif; other site
718274007643	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
718274007644	Protein export membrane protein; Region: SecD_SecF; cl14618
718274007645	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
718274007646	ArsC family; Region: ArsC; pfam03960
718274007647	putative catalytic residues [active]
718274007648	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
718274007649	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
718274007650	metal binding site [ion binding]; metal-binding site
718274007651	dimer interface [polypeptide binding]; other site
718274007652	hypothetical protein; Provisional; Region: PRK13664
718274007653	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
718274007654	Helicase; Region: Helicase_RecD; pfam05127
718274007655	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
718274007656	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
718274007657	Predicted metalloprotease [General function prediction only]; Region: COG2321
718274007658	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
718274007659	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
718274007660	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
718274007661	ATP binding site [chemical binding]; other site
718274007662	active site
718274007663	substrate binding site [chemical binding]; other site
718274007664	lipoprotein; Provisional; Region: PRK11679
718274007665	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
718274007666	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
718274007667	dihydrodipicolinate synthase; Region: dapA; TIGR00674
718274007668	dimer interface [polypeptide binding]; other site
718274007669	active site
718274007670	catalytic residue [active]
718274007671	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
718274007672	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
718274007673	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
718274007674	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
718274007675	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
718274007676	catalytic triad [active]
718274007677	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
718274007678	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
718274007679	Domain of unknown function DUF20; Region: UPF0118; pfam01594
718274007680	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
718274007681	Peptidase family M48; Region: Peptidase_M48; cl12018
718274007682	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
718274007683	ArsC family; Region: ArsC; pfam03960
718274007684	catalytic residues [active]
718274007685	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
718274007686	DNA replication initiation factor; Provisional; Region: PRK08084
718274007687	uracil transporter; Provisional; Region: PRK10720
718274007688	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718274007689	active site
718274007690	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
718274007691	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
718274007692	dimerization interface [polypeptide binding]; other site
718274007693	putative ATP binding site [chemical binding]; other site
718274007694	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
718274007695	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
718274007696	active site
718274007697	substrate binding site [chemical binding]; other site
718274007698	cosubstrate binding site; other site
718274007699	catalytic site [active]
718274007700	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
718274007701	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
718274007702	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
718274007703	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
718274007704	putative active site [active]
718274007705	catalytic site [active]
718274007706	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
718274007707	domain interface [polypeptide binding]; other site
718274007708	active site
718274007709	catalytic site [active]
718274007710	exopolyphosphatase; Provisional; Region: PRK10854
718274007711	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718274007712	nucleotide binding site [chemical binding]; other site
718274007713	MASE1; Region: MASE1; pfam05231
718274007714	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718274007715	diguanylate cyclase; Region: GGDEF; smart00267
718274007716	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274007717	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
718274007718	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
718274007719	Integrase core domain; Region: rve; pfam00665
718274007720	GMP synthase; Reviewed; Region: guaA; PRK00074
718274007721	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
718274007722	AMP/PPi binding site [chemical binding]; other site
718274007723	candidate oxyanion hole; other site
718274007724	catalytic triad [active]
718274007725	potential glutamine specificity residues [chemical binding]; other site
718274007726	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
718274007727	ATP Binding subdomain [chemical binding]; other site
718274007728	Ligand Binding sites [chemical binding]; other site
718274007729	Dimerization subdomain; other site
718274007730	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
718274007731	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
718274007732	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
718274007733	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
718274007734	active site
718274007735	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
718274007736	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
718274007737	generic binding surface II; other site
718274007738	generic binding surface I; other site
718274007739	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
718274007740	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
718274007741	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
718274007742	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
718274007743	Autotransporter beta-domain; Region: Autotransporter; smart00869
718274007744	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
718274007745	outer membrane protein RatB; Provisional; Region: PRK15314
718274007746	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007747	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007748	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007749	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007750	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007751	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007752	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007753	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007754	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007755	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007756	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007757	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007758	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007759	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007760	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007761	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007762	outer membrane protein RatA; Provisional; Region: PRK15315
718274007763	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007764	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007765	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007766	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007767	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007768	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007769	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007770	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007771	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007772	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
718274007773	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
718274007774	intimin-like protein SinH; Provisional; Region: PRK15318
718274007775	intimin-like protein SinH; Provisional; Region: PRK15318
718274007776	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
718274007777	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
718274007778	GTP-binding protein Der; Reviewed; Region: PRK00093
718274007779	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
718274007780	G1 box; other site
718274007781	GTP/Mg2+ binding site [chemical binding]; other site
718274007782	Switch I region; other site
718274007783	G2 box; other site
718274007784	Switch II region; other site
718274007785	G3 box; other site
718274007786	G4 box; other site
718274007787	G5 box; other site
718274007788	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
718274007789	G1 box; other site
718274007790	GTP/Mg2+ binding site [chemical binding]; other site
718274007791	Switch I region; other site
718274007792	G2 box; other site
718274007793	G3 box; other site
718274007794	Switch II region; other site
718274007795	G4 box; other site
718274007796	G5 box; other site
718274007797	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
718274007798	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
718274007799	Trp docking motif [polypeptide binding]; other site
718274007800	active site
718274007801	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
718274007802	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
718274007803	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
718274007804	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
718274007805	dimer interface [polypeptide binding]; other site
718274007806	motif 1; other site
718274007807	active site
718274007808	motif 2; other site
718274007809	motif 3; other site
718274007810	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
718274007811	anticodon binding site; other site
718274007812	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
718274007813	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
718274007814	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
718274007815	cytoskeletal protein RodZ; Provisional; Region: PRK10856
718274007816	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274007817	non-specific DNA binding site [nucleotide binding]; other site
718274007818	salt bridge; other site
718274007819	sequence-specific DNA binding site [nucleotide binding]; other site
718274007820	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
718274007821	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
718274007822	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274007823	FeS/SAM binding site; other site
718274007824	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
718274007825	active site
718274007826	multimer interface [polypeptide binding]; other site
718274007827	4Fe-4S binding domain; Region: Fer4; pfam00037
718274007828	hydrogenase 4 subunit H; Validated; Region: PRK08222
718274007829	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
718274007830	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
718274007831	4Fe-4S binding domain; Region: Fer4; pfam00037
718274007832	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
718274007833	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
718274007834	putative [Fe4-S4] binding site [ion binding]; other site
718274007835	putative molybdopterin cofactor binding site [chemical binding]; other site
718274007836	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
718274007837	putative molybdopterin cofactor binding site; other site
718274007838	penicillin-binding protein 1C; Provisional; Region: PRK11240
718274007839	Transglycosylase; Region: Transgly; pfam00912
718274007840	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
718274007841	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
718274007842	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
718274007843	MG2 domain; Region: A2M_N; pfam01835
718274007844	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
718274007845	surface patch; other site
718274007846	thioester region; other site
718274007847	specificity defining residues; other site
718274007848	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
718274007849	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
718274007850	active site residue [active]
718274007851	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
718274007852	active site residue [active]
718274007853	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
718274007854	aminopeptidase B; Provisional; Region: PRK05015
718274007855	Peptidase; Region: DUF3663; pfam12404
718274007856	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
718274007857	interface (dimer of trimers) [polypeptide binding]; other site
718274007858	Substrate-binding/catalytic site; other site
718274007859	Zn-binding sites [ion binding]; other site
718274007860	hypothetical protein; Provisional; Region: PRK10721
718274007861	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
718274007862	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
718274007863	catalytic loop [active]
718274007864	iron binding site [ion binding]; other site
718274007865	chaperone protein HscA; Provisional; Region: hscA; PRK05183
718274007866	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
718274007867	nucleotide binding site [chemical binding]; other site
718274007868	putative NEF/HSP70 interaction site [polypeptide binding]; other site
718274007869	SBD interface [polypeptide binding]; other site
718274007870	co-chaperone HscB; Provisional; Region: hscB; PRK05014
718274007871	DnaJ domain; Region: DnaJ; pfam00226
718274007872	HSP70 interaction site [polypeptide binding]; other site
718274007873	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
718274007874	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
718274007875	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
718274007876	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
718274007877	trimerization site [polypeptide binding]; other site
718274007878	active site
718274007879	cysteine desulfurase; Provisional; Region: PRK14012
718274007880	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
718274007881	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718274007882	catalytic residue [active]
718274007883	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
718274007884	Rrf2 family protein; Region: rrf2_super; TIGR00738
718274007885	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
718274007886	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
718274007887	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
718274007888	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
718274007889	active site
718274007890	dimerization interface [polypeptide binding]; other site
718274007891	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
718274007892	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
718274007893	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
718274007894	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718274007895	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
718274007896	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
718274007897	FAD binding pocket [chemical binding]; other site
718274007898	FAD binding motif [chemical binding]; other site
718274007899	phosphate binding motif [ion binding]; other site
718274007900	beta-alpha-beta structure motif; other site
718274007901	NAD binding pocket [chemical binding]; other site
718274007902	Iron coordination center [ion binding]; other site
718274007903	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
718274007904	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
718274007905	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718274007906	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
718274007907	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
718274007908	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
718274007909	PRD domain; Region: PRD; pfam00874
718274007910	PRD domain; Region: PRD; pfam00874
718274007911	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
718274007912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274007913	putative substrate translocation pore; other site
718274007914	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
718274007915	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
718274007916	dimer interface [polypeptide binding]; other site
718274007917	active site
718274007918	glycine-pyridoxal phosphate binding site [chemical binding]; other site
718274007919	folate binding site [chemical binding]; other site
718274007920	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
718274007921	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
718274007922	heme-binding site [chemical binding]; other site
718274007923	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
718274007924	FAD binding pocket [chemical binding]; other site
718274007925	FAD binding motif [chemical binding]; other site
718274007926	phosphate binding motif [ion binding]; other site
718274007927	beta-alpha-beta structure motif; other site
718274007928	NAD binding pocket [chemical binding]; other site
718274007929	Heme binding  pocket [chemical binding]; other site
718274007930	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
718274007931	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274007932	DNA binding site [nucleotide binding]
718274007933	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
718274007934	lysine decarboxylase CadA; Provisional; Region: PRK15400
718274007935	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
718274007936	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
718274007937	homodimer interface [polypeptide binding]; other site
718274007938	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274007939	catalytic residue [active]
718274007940	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
718274007941	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
718274007942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274007943	putative substrate translocation pore; other site
718274007944	POT family; Region: PTR2; pfam00854
718274007945	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
718274007946	Nitrogen regulatory protein P-II; Region: P-II; smart00938
718274007947	response regulator GlrR; Provisional; Region: PRK15115
718274007948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274007949	active site
718274007950	phosphorylation site [posttranslational modification]
718274007951	intermolecular recognition site; other site
718274007952	dimerization interface [polypeptide binding]; other site
718274007953	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274007954	Walker A motif; other site
718274007955	ATP binding site [chemical binding]; other site
718274007956	Walker B motif; other site
718274007957	arginine finger; other site
718274007958	hypothetical protein; Provisional; Region: PRK10722
718274007959	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718274007960	HAMP domain; Region: HAMP; pfam00672
718274007961	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274007962	dimer interface [polypeptide binding]; other site
718274007963	phosphorylation site [posttranslational modification]
718274007964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274007965	ATP binding site [chemical binding]; other site
718274007966	Mg2+ binding site [ion binding]; other site
718274007967	G-X-G motif; other site
718274007968	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
718274007969	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
718274007970	dimerization interface [polypeptide binding]; other site
718274007971	ATP binding site [chemical binding]; other site
718274007972	Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193
718274007973	dimerization interface [polypeptide binding]; other site
718274007974	ATP binding site [chemical binding]; other site
718274007975	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
718274007976	putative active site [active]
718274007977	catalytic triad [active]
718274007978	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
718274007979	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274007980	substrate binding pocket [chemical binding]; other site
718274007981	membrane-bound complex binding site; other site
718274007982	hinge residues; other site
718274007983	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718274007984	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718274007985	catalytic residue [active]
718274007986	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
718274007987	nucleoside/Zn binding site; other site
718274007988	dimer interface [polypeptide binding]; other site
718274007989	catalytic motif [active]
718274007990	hypothetical protein; Provisional; Region: PRK11590
718274007991	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
718274007992	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
718274007993	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
718274007994	active site turn [active]
718274007995	phosphorylation site [posttranslational modification]
718274007996	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
718274007997	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
718274007998	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
718274007999	putative active site [active]
718274008000	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
718274008001	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
718274008002	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
718274008003	putative active site [active]
718274008004	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
718274008005	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
718274008006	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
718274008007	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
718274008008	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274008009	putative substrate translocation pore; other site
718274008010	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274008011	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274008012	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718274008013	dimerization interface [polypeptide binding]; other site
718274008014	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
718274008015	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
718274008016	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
718274008017	active site
718274008018	hydrophilic channel; other site
718274008019	dimerization interface [polypeptide binding]; other site
718274008020	catalytic residues [active]
718274008021	active site lid [active]
718274008022	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
718274008023	Recombination protein O N terminal; Region: RecO_N; pfam11967
718274008024	Recombination protein O C terminal; Region: RecO_C; pfam02565
718274008025	GTPase Era; Reviewed; Region: era; PRK00089
718274008026	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
718274008027	G1 box; other site
718274008028	GTP/Mg2+ binding site [chemical binding]; other site
718274008029	Switch I region; other site
718274008030	G2 box; other site
718274008031	Switch II region; other site
718274008032	G3 box; other site
718274008033	G4 box; other site
718274008034	G5 box; other site
718274008035	KH domain; Region: KH_2; pfam07650
718274008036	ribonuclease III; Reviewed; Region: rnc; PRK00102
718274008037	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
718274008038	dimerization interface [polypeptide binding]; other site
718274008039	active site
718274008040	metal binding site [ion binding]; metal-binding site
718274008041	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
718274008042	dsRNA binding site [nucleotide binding]; other site
718274008043	signal peptidase I; Provisional; Region: PRK10861
718274008044	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
718274008045	Catalytic site [active]
718274008046	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
718274008047	GTP-binding protein LepA; Provisional; Region: PRK05433
718274008048	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
718274008049	G1 box; other site
718274008050	putative GEF interaction site [polypeptide binding]; other site
718274008051	GTP/Mg2+ binding site [chemical binding]; other site
718274008052	Switch I region; other site
718274008053	G2 box; other site
718274008054	G3 box; other site
718274008055	Switch II region; other site
718274008056	G4 box; other site
718274008057	G5 box; other site
718274008058	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
718274008059	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
718274008060	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
718274008061	prophage region Salmonella phage Gifsy-1
718274008062	type III secretion protein GogB; Provisional; Region: PRK15386
718274008063	potential protein location (hypothetical protein) that overlaps protein (leucine-rich repeat-containing protein)
718274008064	Integrase core domain; Region: rve_3; cl15866
718274008065	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
718274008066	Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900
718274008067	ADP-ribose binding site [chemical binding]; other site
718274008068	putative active site [active]
718274008069	dimer interface [polypeptide binding]; other site
718274008070	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
718274008071	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
718274008072	Phage Tail Collar Domain; Region: Collar; pfam07484
718274008073	Phage-related protein, tail component [Function unknown]; Region: COG4733
718274008074	Putative phage tail protein; Region: Phage-tail_3; pfam13550
718274008075	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
718274008076	Interdomain contacts; other site
718274008077	Cytokine receptor motif; other site
718274008078	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
718274008079	Fibronectin type III protein; Region: DUF3672; pfam12421
718274008080	Phage-related protein, tail component [Function unknown]; Region: COG4723
718274008081	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
718274008082	MPN+ (JAMM) motif; other site
718274008083	Zinc-binding site [ion binding]; other site
718274008084	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
718274008085	NlpC/P60 family; Region: NLPC_P60; cl17555
718274008086	Phage-related protein [Function unknown]; Region: gp18; COG4672
718274008087	Phage-related protein [Function unknown]; Region: COG4718
718274008088	Phage-related minor tail protein [Function unknown]; Region: COG5281
718274008089	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
718274008090	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
718274008091	Minor tail protein T; Region: Phage_tail_T; pfam06223
718274008092	Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894
718274008093	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
718274008094	Phage tail protein; Region: Phage_tail_3; pfam08813
718274008095	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
718274008096	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
718274008097	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
718274008098	Probable transposase; Region: OrfB_IS605; pfam01385
718274008099	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
718274008100	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
718274008101	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094
718274008102	DNA packaging protein FI; Region: Packaging_FI; pfam14000
718274008103	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
718274008104	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
718274008105	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
718274008106	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
718274008107	tandem repeat interface [polypeptide binding]; other site
718274008108	oligomer interface [polypeptide binding]; other site
718274008109	active site residues [active]
718274008110	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
718274008111	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
718274008112	gpW; Region: gpW; pfam02831
718274008113	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
718274008114	Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471
718274008115	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
718274008116	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
718274008117	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
718274008118	catalytic residues [active]
718274008119	phage holin, lambda family; Region: holin_lambda; TIGR01594
718274008120	PipA protein; Region: PipA; pfam07108
718274008121	ORF6N domain; Region: ORF6N; pfam10543
718274008122	Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323
718274008123	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
718274008124	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
718274008125	DinI-like family; Region: DinI; pfam06183
718274008126	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
718274008127	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
718274008128	putative replication protein; Provisional; Region: PRK12377
718274008129	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274008130	Walker A motif; other site
718274008131	ATP binding site [chemical binding]; other site
718274008132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
718274008133	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
718274008134	primosomal protein DnaI; Provisional; Region: PRK02854
718274008135	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
718274008136	DNA binding residues [nucleotide binding]
718274008137	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274008138	non-specific DNA binding site [nucleotide binding]; other site
718274008139	salt bridge; other site
718274008140	sequence-specific DNA binding site [nucleotide binding]; other site
718274008141	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
718274008142	exonuclease VIII; Reviewed; Region: PRK09709
718274008143	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
718274008144	RecT family; Region: RecT; pfam03837
718274008145	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
718274008146	integrase; Provisional; Region: PRK09692
718274008147	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
718274008148	active site
718274008149	Int/Topo IB signature motif; other site
718274008150	SoxR reducing system protein RseC; Provisional; Region: PRK10862
718274008151	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
718274008152	anti-sigma E factor; Provisional; Region: rseB; PRK09455
718274008153	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
718274008154	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
718274008155	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
718274008156	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
718274008157	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718274008158	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718274008159	DNA binding residues [nucleotide binding]
718274008160	L-aspartate oxidase; Provisional; Region: PRK09077
718274008161	L-aspartate oxidase; Provisional; Region: PRK06175
718274008162	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
718274008163	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
718274008164	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274008165	S-adenosylmethionine binding site [chemical binding]; other site
718274008166	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
718274008167	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
718274008168	ATP binding site [chemical binding]; other site
718274008169	Mg++ binding site [ion binding]; other site
718274008170	motif III; other site
718274008171	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274008172	nucleotide binding region [chemical binding]; other site
718274008173	ATP-binding site [chemical binding]; other site
718274008174	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274008175	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274008176	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718274008177	dimerization interface [polypeptide binding]; other site
718274008178	cysteine/O-acetylserine exporter; Provisional; Region: PRK10323
718274008179	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
718274008180	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
718274008181	ligand binding site [chemical binding]; other site
718274008182	active site
718274008183	UGI interface [polypeptide binding]; other site
718274008184	catalytic site [active]
718274008185	putative methyltransferase; Provisional; Region: PRK10864
718274008186	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
718274008187	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
718274008188	thioredoxin 2; Provisional; Region: PRK10996
718274008189	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
718274008190	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
718274008191	catalytic residues [active]
718274008192	Uncharacterized conserved protein [Function unknown]; Region: COG3148
718274008193	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
718274008194	CoA binding domain; Region: CoA_binding_2; pfam13380
718274008195	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
718274008196	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
718274008197	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
718274008198	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274008199	Coenzyme A binding pocket [chemical binding]; other site
718274008200	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
718274008201	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
718274008202	domain interface [polypeptide binding]; other site
718274008203	putative active site [active]
718274008204	catalytic site [active]
718274008205	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
718274008206	domain interface [polypeptide binding]; other site
718274008207	putative active site [active]
718274008208	catalytic site [active]
718274008209	lipoprotein; Provisional; Region: PRK10759
718274008210	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
718274008211	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274008212	putative substrate translocation pore; other site
718274008213	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
718274008214	protein disaggregation chaperone; Provisional; Region: PRK10865
718274008215	Clp amino terminal domain; Region: Clp_N; pfam02861
718274008216	Clp amino terminal domain; Region: Clp_N; pfam02861
718274008217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274008218	Walker A motif; other site
718274008219	ATP binding site [chemical binding]; other site
718274008220	Walker B motif; other site
718274008221	arginine finger; other site
718274008222	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274008223	Walker A motif; other site
718274008224	ATP binding site [chemical binding]; other site
718274008225	Walker B motif; other site
718274008226	arginine finger; other site
718274008227	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
718274008228	hypothetical protein; Provisional; Region: PRK10723
718274008229	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
718274008230	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
718274008231	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718274008232	RNA binding surface [nucleotide binding]; other site
718274008233	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
718274008234	active site
718274008235	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
718274008236	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
718274008237	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
718274008238	30S subunit binding site; other site
718274008239	prophage region Salmonella T000240 prophage
718274008240	baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596
718274008241	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
718274008242	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
718274008243	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
718274008244	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
718274008245	Baseplate J-like protein; Region: Baseplate_J; cl01294
718274008246	Baseplate J-like protein; Region: Baseplate_J; pfam04865
718274008247	Protein of unknown function (DUF2590); Region: DUF2590; pfam10761
718274008248	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
718274008249	Protein of unknown function (DUF2765); Region: DUF2765; pfam10963
718274008250	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
718274008251	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
718274008252	Phage holin family 2; Region: Phage_holin_2; pfam04550
718274008253	Protein of unknown function (DUF2597); Region: DUF2597; pfam10772
718274008254	Protein of unknown function (DUF2586); Region: DUF2586; pfam10758
718274008255	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
718274008256	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
718274008257	terminase endonuclease subunit; Provisional; Region: M; PHA02537
718274008258	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
718274008259	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
718274008260	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
718274008261	terminase ATPase subunit; Provisional; Region: P; PHA02535
718274008262	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
718274008263	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
718274008264	Phage-related protein [Function unknown]; Region: COG4695; cl01923
718274008265	Phage portal protein; Region: Phage_portal; pfam04860
718274008266	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
718274008267	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
718274008268	active site
718274008269	metal binding site [ion binding]; metal-binding site
718274008270	interdomain interaction site; other site
718274008271	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
718274008272	Regulatory phage protein cox; Region: Phage_Cox; pfam10743
718274008273	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274008274	non-specific DNA binding site [nucleotide binding]; other site
718274008275	salt bridge; other site
718274008276	sequence-specific DNA binding site [nucleotide binding]; other site
718274008277	integrase; Provisional; Region: int; PHA02601
718274008278	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718274008279	active site
718274008280	DNA binding site [nucleotide binding]
718274008281	Int/Topo IB signature motif; other site
718274008282	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
718274008283	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
718274008284	Prephenate dehydratase; Region: PDT; pfam00800
718274008285	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
718274008286	putative L-Phe binding site [chemical binding]; other site
718274008287	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
718274008288	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
718274008289	Chorismate mutase type II; Region: CM_2; cl00693
718274008290	prephenate dehydrogenase; Validated; Region: PRK08507
718274008291	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
718274008292	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
718274008293	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
718274008294	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
718274008295	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718274008296	metal binding site [ion binding]; metal-binding site
718274008297	active site
718274008298	I-site; other site
718274008299	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
718274008300	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
718274008301	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
718274008302	RimM N-terminal domain; Region: RimM; pfam01782
718274008303	PRC-barrel domain; Region: PRC; pfam05239
718274008304	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
718274008305	signal recognition particle protein; Provisional; Region: PRK10867
718274008306	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
718274008307	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
718274008308	P loop; other site
718274008309	GTP binding site [chemical binding]; other site
718274008310	Signal peptide binding domain; Region: SRP_SPB; pfam02978
718274008311	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
718274008312	hypothetical protein; Provisional; Region: PRK11573
718274008313	Domain of unknown function DUF21; Region: DUF21; pfam01595
718274008314	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
718274008315	Transporter associated domain; Region: CorC_HlyC; smart01091
718274008316	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
718274008317	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
718274008318	dimer interface [polypeptide binding]; other site
718274008319	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
718274008320	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
718274008321	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
718274008322	recombination and repair protein; Provisional; Region: PRK10869
718274008323	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
718274008324	Walker A/P-loop; other site
718274008325	ATP binding site [chemical binding]; other site
718274008326	Q-loop/lid; other site
718274008327	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
718274008328	ABC transporter signature motif; other site
718274008329	Walker B; other site
718274008330	D-loop; other site
718274008331	H-loop/switch region; other site
718274008332	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
718274008333	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
718274008334	hypothetical protein; Validated; Region: PRK01777
718274008335	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
718274008336	putative coenzyme Q binding site [chemical binding]; other site
718274008337	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
718274008338	SmpB-tmRNA interface; other site
718274008339	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008340	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008341	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008342	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008343	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008344	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008345	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008346	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008347	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008348	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008349	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008350	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
718274008351	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008352	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008353	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
718274008354	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008355	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274008356	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
718274008357	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
718274008358	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
718274008359	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718274008360	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274008361	Walker A/P-loop; other site
718274008362	ATP binding site [chemical binding]; other site
718274008363	Q-loop/lid; other site
718274008364	ABC transporter signature motif; other site
718274008365	Walker B; other site
718274008366	D-loop; other site
718274008367	H-loop/switch region; other site
718274008368	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
718274008369	HlyD family secretion protein; Region: HlyD_3; pfam13437
718274008370	prophage region Salmonella phage Fels-2
718274008371	DNA-binding transcriptional regulator; Provisional; Region: PRK09678
718274008372	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
718274008373	tail protein; Provisional; Region: D; PHA02561
718274008374	Phage protein U [General function prediction only]; Region: COG3499
718274008375	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
718274008376	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
718274008377	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
718274008378	major tail tube protein; Provisional; Region: FII; PHA02600
718274008379	major tail sheath protein; Provisional; Region: FI; PHA02560
718274008380	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718274008381	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
718274008382	catalytic residues [active]
718274008383	catalytic nucleophile [active]
718274008384	Presynaptic Site I dimer interface [polypeptide binding]; other site
718274008385	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
718274008386	Synaptic Flat tetramer interface [polypeptide binding]; other site
718274008387	Synaptic Site I dimer interface [polypeptide binding]; other site
718274008388	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
718274008389	DNA-binding interface [nucleotide binding]; DNA binding site
718274008390	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
718274008391	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
718274008392	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
718274008393	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
718274008394	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
718274008395	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
718274008396	baseplate assembly protein; Provisional; Region: J; PHA02568
718274008397	baseplate wedge subunit; Provisional; Region: W; PHA02516
718274008398	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
718274008399	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
718274008400	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
718274008401	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
718274008402	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
718274008403	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
718274008404	catalytic residues [active]
718274008405	P2-like prophage tail protein X [General function prediction only]; Region: COG5004
718274008406	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
718274008407	terminase endonuclease subunit; Provisional; Region: M; PHA02537
718274008408	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
718274008409	capsid protein; Provisional; Region: N; PHA02538
718274008410	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929
718274008411	terminase ATPase subunit; Provisional; Region: P; PHA02535
718274008412	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
718274008413	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
718274008414	portal vertex protein; Provisional; Region: Q; PHA02536
718274008415	Phage portal protein; Region: Phage_portal; pfam04860
718274008416	AIPR protein; Region: AIPR; pfam10592
718274008417	DinI-like family; Region: DinI; pfam06183
718274008418	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
718274008419	DNA adenine methylase (dam); Region: dam; TIGR00571
718274008420	DksA-like zinc finger domain containing protein; Region: PHA00080
718274008421	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
718274008422	Protein of unknown function (DUF2724); Region: DUF2724; pfam10893
718274008423	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
718274008424	Predicted transcriptional regulator [Transcription]; Region: COG2932
718274008425	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
718274008426	integrase; Provisional; Region: int; PHA02601
718274008427	Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family.  They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797
718274008428	dimer interface [polypeptide binding]; other site
718274008429	active site
718274008430	catalytic residues [active]
718274008431	Int/Topo IB signature motif; other site
718274008432	SEC-C motif; Region: SEC-C; pfam02810
718274008433	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
718274008434	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
718274008435	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
718274008436	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
718274008437	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274008438	non-specific DNA binding site [nucleotide binding]; other site
718274008439	salt bridge; other site
718274008440	sequence-specific DNA binding site [nucleotide binding]; other site
718274008441	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
718274008442	Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730
718274008443	Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731
718274008444	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
718274008445	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
718274008446	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
718274008447	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
718274008448	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
718274008449	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
718274008450	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
718274008451	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
718274008452	active site
718274008453	dimer interface [polypeptide binding]; other site
718274008454	magnesium binding site [ion binding]; other site
718274008455	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
718274008456	tetramer interface [polypeptide binding]; other site
718274008457	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
718274008458	active site
718274008459	Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140
718274008460	Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560
718274008461	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
718274008462	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
718274008463	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
718274008464	active site turn [active]
718274008465	phosphorylation site [posttranslational modification]
718274008466	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
718274008467	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
718274008468	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
718274008469	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
718274008470	Integrase; Region: Integrase_1; pfam12835
718274008471	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718274008472	Integrase core domain; Region: rve; pfam00665
718274008473	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
718274008474	DNA-binding interface [nucleotide binding]; DNA binding site
718274008475	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
718274008476	Family description; Region: UvrD_C_2; pfam13538
718274008477	Transposase; Region: HTH_Tnp_1; cl17663
718274008478	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
718274008479	putative transposase OrfB; Reviewed; Region: PHA02517
718274008480	HTH-like domain; Region: HTH_21; pfam13276
718274008481	Integrase core domain; Region: rve; pfam00665
718274008482	Integrase core domain; Region: rve_2; pfam13333
718274008483	Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614
718274008484	flagellin; Validated; Region: PRK08026
718274008485	Flagellin D3 domain; Region: Flagellin_D3; pfam08884
718274008486	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
718274008487	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
718274008488	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718274008489	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
718274008490	catalytic residues [active]
718274008491	catalytic nucleophile [active]
718274008492	Presynaptic Site I dimer interface [polypeptide binding]; other site
718274008493	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
718274008494	Synaptic Flat tetramer interface [polypeptide binding]; other site
718274008495	Synaptic Site I dimer interface [polypeptide binding]; other site
718274008496	DNA binding site [nucleotide binding]
718274008497	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
718274008498	DNA-binding interface [nucleotide binding]; DNA binding site
718274008499	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
718274008500	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
718274008501	homodimer interface [polypeptide binding]; other site
718274008502	active site
718274008503	TDP-binding site; other site
718274008504	acceptor substrate-binding pocket; other site
718274008505	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718274008506	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274008507	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
718274008508	Walker A/P-loop; other site
718274008509	ATP binding site [chemical binding]; other site
718274008510	Q-loop/lid; other site
718274008511	ABC transporter signature motif; other site
718274008512	Walker B; other site
718274008513	D-loop; other site
718274008514	H-loop/switch region; other site
718274008515	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
718274008516	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
718274008517	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274008518	Walker A/P-loop; other site
718274008519	ATP binding site [chemical binding]; other site
718274008520	Q-loop/lid; other site
718274008521	ABC transporter signature motif; other site
718274008522	Walker B; other site
718274008523	D-loop; other site
718274008524	H-loop/switch region; other site
718274008525	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
718274008526	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
718274008527	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
718274008528	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
718274008529	outer membrane receptor FepA; Provisional; Region: PRK13528
718274008530	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
718274008531	N-terminal plug; other site
718274008532	ligand-binding site [chemical binding]; other site
718274008533	secreted effector protein PipB2; Provisional; Region: PRK15196
718274008534	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
718274008535	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
718274008536	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
718274008537	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
718274008538	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
718274008539	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
718274008540	antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312
718274008541	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
718274008542	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
718274008543	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
718274008544	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
718274008545	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
718274008546	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274008547	dimer interface [polypeptide binding]; other site
718274008548	phosphorylation site [posttranslational modification]
718274008549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274008550	ATP binding site [chemical binding]; other site
718274008551	Mg2+ binding site [ion binding]; other site
718274008552	G-X-G motif; other site
718274008553	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
718274008554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274008555	active site
718274008556	phosphorylation site [posttranslational modification]
718274008557	intermolecular recognition site; other site
718274008558	dimerization interface [polypeptide binding]; other site
718274008559	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274008560	DNA binding site [nucleotide binding]
718274008561	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
718274008562	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
718274008563	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
718274008564	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
718274008565	substrate binding pocket [chemical binding]; other site
718274008566	active site
718274008567	iron coordination sites [ion binding]; other site
718274008568	Predicted dehydrogenase [General function prediction only]; Region: COG0579
718274008569	hydroxyglutarate oxidase; Provisional; Region: PRK11728
718274008570	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
718274008571	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
718274008572	tetramerization interface [polypeptide binding]; other site
718274008573	NAD(P) binding site [chemical binding]; other site
718274008574	catalytic residues [active]
718274008575	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
718274008576	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
718274008577	inhibitor-cofactor binding pocket; inhibition site
718274008578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274008579	catalytic residue [active]
718274008580	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
718274008581	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
718274008582	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274008583	DNA-binding site [nucleotide binding]; DNA binding site
718274008584	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
718274008585	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
718274008586	bacterial OsmY and nodulation domain; Region: BON; smart00749
718274008587	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718274008588	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
718274008589	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718274008590	dimerization interface [polypeptide binding]; other site
718274008591	putative DNA binding site [nucleotide binding]; other site
718274008592	Transcriptional regulators [Transcription]; Region: MarR; COG1846
718274008593	putative Zn2+ binding site [ion binding]; other site
718274008594	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
718274008595	active site residue [active]
718274008596	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
718274008597	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
718274008598	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
718274008599	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
718274008600	hypothetical protein; Provisional; Region: PRK10556
718274008601	hypothetical protein; Provisional; Region: PRK10132
718274008602	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
718274008603	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274008604	DNA-binding site [nucleotide binding]; DNA binding site
718274008605	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718274008606	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274008607	homodimer interface [polypeptide binding]; other site
718274008608	catalytic residue [active]
718274008609	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
718274008610	Uncharacterized conserved protein [Function unknown]; Region: COG2128
718274008611	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
718274008612	catalytic residues [active]
718274008613	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
718274008614	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
718274008615	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
718274008616	Class I ribonucleotide reductase; Region: RNR_I; cd01679
718274008617	active site
718274008618	dimer interface [polypeptide binding]; other site
718274008619	catalytic residues [active]
718274008620	effector binding site; other site
718274008621	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
718274008622	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
718274008623	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
718274008624	dimer interface [polypeptide binding]; other site
718274008625	putative radical transfer pathway; other site
718274008626	diiron center [ion binding]; other site
718274008627	tyrosyl radical; other site
718274008628	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
718274008629	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
718274008630	Walker A/P-loop; other site
718274008631	ATP binding site [chemical binding]; other site
718274008632	Q-loop/lid; other site
718274008633	ABC transporter signature motif; other site
718274008634	Walker B; other site
718274008635	D-loop; other site
718274008636	H-loop/switch region; other site
718274008637	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
718274008638	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
718274008639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274008640	dimer interface [polypeptide binding]; other site
718274008641	conserved gate region; other site
718274008642	putative PBP binding loops; other site
718274008643	ABC-ATPase subunit interface; other site
718274008644	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
718274008645	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
718274008646	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
718274008647	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274008648	transcriptional repressor MprA; Provisional; Region: PRK10870
718274008649	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
718274008650	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
718274008651	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718274008652	HlyD family secretion protein; Region: HlyD_3; pfam13437
718274008653	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
718274008654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274008655	putative substrate translocation pore; other site
718274008656	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274008657	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
718274008658	S-ribosylhomocysteinase; Provisional; Region: PRK02260
718274008659	glutamate--cysteine ligase; Provisional; Region: PRK02107
718274008660	Predicted membrane protein [Function unknown]; Region: COG1238
718274008661	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
718274008662	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274008663	motif II; other site
718274008664	carbon storage regulator; Provisional; Region: PRK01712
718274008665	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
718274008666	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
718274008667	motif 1; other site
718274008668	active site
718274008669	motif 2; other site
718274008670	motif 3; other site
718274008671	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
718274008672	DHHA1 domain; Region: DHHA1; pfam02272
718274008673	recombination regulator RecX; Reviewed; Region: recX; PRK00117
718274008674	recombinase A; Provisional; Region: recA; PRK09354
718274008675	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
718274008676	hexamer interface [polypeptide binding]; other site
718274008677	Walker A motif; other site
718274008678	ATP binding site [chemical binding]; other site
718274008679	Walker B motif; other site
718274008680	hypothetical protein; Validated; Region: PRK03661
718274008681	Transglycosylase SLT domain; Region: SLT_2; pfam13406
718274008682	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718274008683	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718274008684	PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821
718274008685	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
718274008686	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
718274008687	Nucleoside recognition; Region: Gate; pfam07670
718274008688	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
718274008689	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
718274008690	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
718274008691	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
718274008692	putative NAD(P) binding site [chemical binding]; other site
718274008693	active site
718274008694	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
718274008695	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
718274008696	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
718274008697	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274008698	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
718274008699	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
718274008700	putative active site [active]
718274008701	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
718274008702	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
718274008703	GAF domain; Region: GAF; pfam01590
718274008704	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274008705	Walker A motif; other site
718274008706	ATP binding site [chemical binding]; other site
718274008707	Walker B motif; other site
718274008708	arginine finger; other site
718274008709	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
718274008710	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
718274008711	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
718274008712	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
718274008713	iron binding site [ion binding]; other site
718274008714	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
718274008715	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718274008716	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274008717	Acylphosphatase; Region: Acylphosphatase; pfam00708
718274008718	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
718274008719	HypF finger; Region: zf-HYPF; pfam07503
718274008720	HypF finger; Region: zf-HYPF; pfam07503
718274008721	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
718274008722	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
718274008723	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
718274008724	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
718274008725	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
718274008726	nickel binding site [ion binding]; other site
718274008727	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
718274008728	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
718274008729	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
718274008730	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
718274008731	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
718274008732	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
718274008733	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
718274008734	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
718274008735	NADH dehydrogenase; Region: NADHdh; cl00469
718274008736	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
718274008737	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
718274008738	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
718274008739	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
718274008740	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
718274008741	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
718274008742	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
718274008743	hydrogenase assembly chaperone; Provisional; Region: PRK10409
718274008744	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
718274008745	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
718274008746	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
718274008747	dimerization interface [polypeptide binding]; other site
718274008748	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
718274008749	ATP binding site [chemical binding]; other site
718274008750	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
718274008751	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
718274008752	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
718274008753	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274008754	Walker A motif; other site
718274008755	ATP binding site [chemical binding]; other site
718274008756	Walker B motif; other site
718274008757	arginine finger; other site
718274008758	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
718274008759	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
718274008760	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
718274008761	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
718274008762	metal binding site [ion binding]; metal-binding site
718274008763	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
718274008764	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
718274008765	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
718274008766	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718274008767	ABC-ATPase subunit  interface; other site
718274008768	dimer interface [polypeptide binding]; other site
718274008769	putative PBP binding regions; other site
718274008770	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
718274008771	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718274008772	ABC-ATPase subunit  interface; other site
718274008773	dimer interface [polypeptide binding]; other site
718274008774	putative PBP binding regions; other site
718274008775	effector protein YopJ; Provisional; Region: PRK15371
718274008776	transcriptional activator SprB; Provisional; Region: PRK15320
718274008777	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
718274008778	transcriptional regulator SirC; Provisional; Region: PRK15044
718274008779	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274008780	putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321
718274008781	invasion protein OrgB; Provisional; Region: PRK15322
718274008782	type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555
718274008783	invasion protein OrgA; Provisional; Region: PRK15323
718274008784	type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324
718274008785	type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325
718274008786	type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326
718274008787	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327
718274008788	Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480
718274008789	transcriptional regulator HilD; Provisional; Region: PRK15185
718274008790	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274008791	invasion protein regulator; Provisional; Region: PRK12370
718274008792	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274008793	DNA binding site [nucleotide binding]
718274008794	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718274008795	binding surface
718274008796	TPR motif; other site
718274008797	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
718274008798	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718274008799	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718274008800	catalytic residue [active]
718274008801	pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375
718274008802	SicP binding; Region: SicP-binding; pfam09119
718274008803	GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219
718274008804	switch II binding region; other site
718274008805	Rac1 P-loop interaction site [polypeptide binding]; other site
718274008806	GTP binding residues [chemical binding]; other site
718274008807	switch I binding region; other site
718274008808	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047
718274008809	active site
718274008810	chaperone protein SicP; Provisional; Region: PRK15329
718274008811	putative acyl carrier protein IacP; Validated; Region: PRK08172
718274008812	pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376
718274008813	cell invasion protein SipD; Provisional; Region: PRK15330
718274008814	pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373
718274008815	pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374
718274008816	chaperone protein SicA; Provisional; Region: PRK15331
718274008817	Tetratricopeptide repeat; Region: TPR_3; pfam07720
718274008818	Tetratricopeptide repeat; Region: TPR_3; pfam07720
718274008819	type III secretion system protein SpaS; Validated; Region: PRK08156
718274008820	type III secretion system protein SpaR; Provisional; Region: PRK15332
718274008821	type III secretion system protein SpaQ; Provisional; Region: PRK15333
718274008822	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
718274008823	type III secretion system protein SpaO; Validated; Region: PRK08158
718274008824	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
718274008825	antigen presentation protein SpaN; Provisional; Region: PRK15334
718274008826	Surface presentation of antigens protein; Region: SPAN; pfam02510
718274008827	Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090
718274008828	ATP synthase SpaL; Validated; Region: PRK08149
718274008829	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
718274008830	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
718274008831	Walker A motif; other site
718274008832	ATP binding site [chemical binding]; other site
718274008833	Walker B motif; other site
718274008834	type III secretion system chaperone SpaK; Provisional; Region: PRK15336
718274008835	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
718274008836	type III secretion system protein InvA; Provisional; Region: PRK15337
718274008837	type III secretion system regulator InvE; Provisional; Region: PRK15338
718274008838	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
718274008839	type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339
718274008840	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
718274008841	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
718274008842	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
718274008843	transcriptional regulator InvF; Provisional; Region: PRK15340
718274008844	InvH outer membrane lipoprotein; Region: InvH; pfam04741
718274008845	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
718274008846	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
718274008847	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
718274008848	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
718274008849	active site
718274008850	metal binding site [ion binding]; metal-binding site
718274008851	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
718274008852	MutS domain I; Region: MutS_I; pfam01624
718274008853	MutS domain II; Region: MutS_II; pfam05188
718274008854	MutS domain III; Region: MutS_III; pfam05192
718274008855	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
718274008856	Walker A/P-loop; other site
718274008857	ATP binding site [chemical binding]; other site
718274008858	Q-loop/lid; other site
718274008859	ABC transporter signature motif; other site
718274008860	Walker B; other site
718274008861	D-loop; other site
718274008862	H-loop/switch region; other site
718274008863	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
718274008864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274008865	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718274008866	putative substrate translocation pore; other site
718274008867	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274008868	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274008869	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
718274008870	putative effector binding pocket; other site
718274008871	dimerization interface [polypeptide binding]; other site
718274008872	GntP family permease; Region: GntP_permease; pfam02447
718274008873	fructuronate transporter; Provisional; Region: PRK10034; cl15264
718274008874	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
718274008875	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
718274008876	putative NAD(P) binding site [chemical binding]; other site
718274008877	active site
718274008878	putative substrate binding site [chemical binding]; other site
718274008879	hypothetical protein; Provisional; Region: PRK09989
718274008880	putative aldolase; Validated; Region: PRK08130
718274008881	intersubunit interface [polypeptide binding]; other site
718274008882	active site
718274008883	Zn2+ binding site [ion binding]; other site
718274008884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
718274008885	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
718274008886	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
718274008887	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
718274008888	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
718274008889	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274008890	MarR family; Region: MarR_2; cl17246
718274008891	Transcriptional regulators [Transcription]; Region: MarR; COG1846
718274008892	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
718274008893	Flavoprotein; Region: Flavoprotein; pfam02441
718274008894	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
718274008895	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
718274008896	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
718274008897	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718274008898	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
718274008899	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718274008900	DNA binding residues [nucleotide binding]
718274008901	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
718274008902	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718274008903	Peptidase family M23; Region: Peptidase_M23; pfam01551
718274008904	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
718274008905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274008906	S-adenosylmethionine binding site [chemical binding]; other site
718274008907	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
718274008908	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
718274008909	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
718274008910	Permutation of conserved domain; other site
718274008911	active site
718274008912	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
718274008913	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
718274008914	homotrimer interaction site [polypeptide binding]; other site
718274008915	zinc binding site [ion binding]; other site
718274008916	CDP-binding sites; other site
718274008917	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
718274008918	substrate binding site; other site
718274008919	dimer interface; other site
718274008920	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
718274008921	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
718274008922	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
718274008923	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
718274008924	ligand-binding site [chemical binding]; other site
718274008925	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
718274008926	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
718274008927	CysD dimerization site [polypeptide binding]; other site
718274008928	G1 box; other site
718274008929	putative GEF interaction site [polypeptide binding]; other site
718274008930	GTP/Mg2+ binding site [chemical binding]; other site
718274008931	Switch I region; other site
718274008932	G2 box; other site
718274008933	G3 box; other site
718274008934	Switch II region; other site
718274008935	G4 box; other site
718274008936	G5 box; other site
718274008937	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
718274008938	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
718274008939	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
718274008940	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
718274008941	Active Sites [active]
718274008942	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
718274008943	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
718274008944	metal binding site [ion binding]; metal-binding site
718274008945	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
718274008946	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
718274008947	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
718274008948	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
718274008949	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
718274008950	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646
718274008951	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
718274008952	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669
718274008953	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
718274008954	CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203
718274008955	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
718274008956	pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379
718274008957	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
718274008958	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
718274008959	Active Sites [active]
718274008960	sulfite reductase subunit beta; Provisional; Region: PRK13504
718274008961	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
718274008962	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
718274008963	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
718274008964	Flavodoxin; Region: Flavodoxin_1; pfam00258
718274008965	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
718274008966	FAD binding pocket [chemical binding]; other site
718274008967	FAD binding motif [chemical binding]; other site
718274008968	catalytic residues [active]
718274008969	NAD binding pocket [chemical binding]; other site
718274008970	phosphate binding motif [ion binding]; other site
718274008971	beta-alpha-beta structure motif; other site
718274008972	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
718274008973	active site
718274008974	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
718274008975	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
718274008976	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
718274008977	enolase; Provisional; Region: eno; PRK00077
718274008978	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
718274008979	dimer interface [polypeptide binding]; other site
718274008980	metal binding site [ion binding]; metal-binding site
718274008981	substrate binding pocket [chemical binding]; other site
718274008982	CTP synthetase; Validated; Region: pyrG; PRK05380
718274008983	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
718274008984	Catalytic site [active]
718274008985	active site
718274008986	UTP binding site [chemical binding]; other site
718274008987	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
718274008988	active site
718274008989	putative oxyanion hole; other site
718274008990	catalytic triad [active]
718274008991	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
718274008992	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
718274008993	homodimer interface [polypeptide binding]; other site
718274008994	metal binding site [ion binding]; metal-binding site
718274008995	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
718274008996	homodimer interface [polypeptide binding]; other site
718274008997	active site
718274008998	putative chemical substrate binding site [chemical binding]; other site
718274008999	metal binding site [ion binding]; metal-binding site
718274009000	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
718274009001	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
718274009002	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
718274009003	HD domain; Region: HD_4; pfam13328
718274009004	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
718274009005	synthetase active site [active]
718274009006	NTP binding site [chemical binding]; other site
718274009007	metal binding site [ion binding]; metal-binding site
718274009008	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
718274009009	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
718274009010	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
718274009011	TRAM domain; Region: TRAM; pfam01938
718274009012	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274009013	S-adenosylmethionine binding site [chemical binding]; other site
718274009014	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
718274009015	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
718274009016	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274009017	dimerization interface [polypeptide binding]; other site
718274009018	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274009019	dimer interface [polypeptide binding]; other site
718274009020	phosphorylation site [posttranslational modification]
718274009021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274009022	ATP binding site [chemical binding]; other site
718274009023	Mg2+ binding site [ion binding]; other site
718274009024	G-X-G motif; other site
718274009025	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
718274009026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274009027	active site
718274009028	phosphorylation site [posttranslational modification]
718274009029	intermolecular recognition site; other site
718274009030	dimerization interface [polypeptide binding]; other site
718274009031	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
718274009032	putative binding surface; other site
718274009033	active site
718274009034	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
718274009035	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
718274009036	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
718274009037	active site
718274009038	tetramer interface [polypeptide binding]; other site
718274009039	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
718274009040	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
718274009041	active site
718274009042	tetramer interface [polypeptide binding]; other site
718274009043	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274009044	D-galactonate transporter; Region: 2A0114; TIGR00893
718274009045	putative substrate translocation pore; other site
718274009046	flavodoxin; Provisional; Region: PRK08105
718274009047	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
718274009048	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
718274009049	probable active site [active]
718274009050	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
718274009051	SecY interacting protein Syd; Provisional; Region: PRK04968
718274009052	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
718274009053	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
718274009054	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
718274009055	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
718274009056	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
718274009057	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
718274009058	serine transporter; Region: stp; TIGR00814
718274009059	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
718274009060	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
718274009061	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
718274009062	flap endonuclease-like protein; Provisional; Region: PRK09482
718274009063	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
718274009064	active site
718274009065	metal binding site 1 [ion binding]; metal-binding site
718274009066	putative 5' ssDNA interaction site; other site
718274009067	metal binding site 3; metal-binding site
718274009068	metal binding site 2 [ion binding]; metal-binding site
718274009069	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
718274009070	putative DNA binding site [nucleotide binding]; other site
718274009071	putative metal binding site [ion binding]; other site
718274009072	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
718274009073	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
718274009074	dimer interface [polypeptide binding]; other site
718274009075	active site
718274009076	metal binding site [ion binding]; metal-binding site
718274009077	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
718274009078	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
718274009079	intersubunit interface [polypeptide binding]; other site
718274009080	active site
718274009081	Zn2+ binding site [ion binding]; other site
718274009082	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
718274009083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274009084	putative substrate translocation pore; other site
718274009085	L-fucose isomerase; Provisional; Region: fucI; PRK10991
718274009086	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
718274009087	hexamer (dimer of trimers) interface [polypeptide binding]; other site
718274009088	trimer interface [polypeptide binding]; other site
718274009089	substrate binding site [chemical binding]; other site
718274009090	Mn binding site [ion binding]; other site
718274009091	L-fuculokinase; Provisional; Region: PRK10331
718274009092	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
718274009093	nucleotide binding site [chemical binding]; other site
718274009094	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
718274009095	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
718274009096	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
718274009097	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274009098	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
718274009099	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
718274009100	hypothetical protein; Provisional; Region: PRK10873
718274009101	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
718274009102	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274009103	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
718274009104	dimerization interface [polypeptide binding]; other site
718274009105	substrate binding pocket [chemical binding]; other site
718274009106	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
718274009107	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
718274009108	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
718274009109	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718274009110	catalytic residue [active]
718274009111	CsdA-binding activator; Provisional; Region: PRK15019
718274009112	Predicted permeases [General function prediction only]; Region: RarD; COG2962
718274009113	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
718274009114	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
718274009115	putative ATP binding site [chemical binding]; other site
718274009116	putative substrate interface [chemical binding]; other site
718274009117	murein transglycosylase A; Provisional; Region: mltA; PRK11162
718274009118	murein hydrolase B; Provisional; Region: PRK10760; cl17906
718274009119	MltA specific insert domain; Region: MltA; pfam03562
718274009120	3D domain; Region: 3D; pfam06725
718274009121	AMIN domain; Region: AMIN; pfam11741
718274009122	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
718274009123	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
718274009124	active site
718274009125	metal binding site [ion binding]; metal-binding site
718274009126	N-acetylglutamate synthase; Validated; Region: PRK05279
718274009127	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
718274009128	putative feedback inhibition sensing region; other site
718274009129	putative nucleotide binding site [chemical binding]; other site
718274009130	putative substrate binding site [chemical binding]; other site
718274009131	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274009132	Coenzyme A binding pocket [chemical binding]; other site
718274009133	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
718274009134	AAA domain; Region: AAA_30; pfam13604
718274009135	Family description; Region: UvrD_C_2; pfam13538
718274009136	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
718274009137	protease3; Provisional; Region: PRK15101
718274009138	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
718274009139	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
718274009140	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
718274009141	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
718274009142	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
718274009143	hypothetical protein; Provisional; Region: PRK10332
718274009144	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
718274009145	hypothetical protein; Provisional; Region: PRK11521
718274009146	hypothetical protein; Provisional; Region: PRK10557
718274009147	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
718274009148	hypothetical protein; Provisional; Region: PRK10506
718274009149	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
718274009150	thymidylate synthase; Reviewed; Region: thyA; PRK01827
718274009151	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
718274009152	dimerization interface [polypeptide binding]; other site
718274009153	active site
718274009154	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
718274009155	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
718274009156	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
718274009157	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
718274009158	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
718274009159	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
718274009160	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
718274009161	putative active site [active]
718274009162	Ap4A binding site [chemical binding]; other site
718274009163	nudix motif; other site
718274009164	putative metal binding site [ion binding]; other site
718274009165	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
718274009166	putative DNA-binding cleft [nucleotide binding]; other site
718274009167	putative DNA clevage site; other site
718274009168	molecular lever; other site
718274009169	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
718274009170	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
718274009171	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718274009172	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718274009173	active site
718274009174	catalytic tetrad [active]
718274009175	lysophospholipid transporter LplT; Provisional; Region: PRK11195
718274009176	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274009177	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
718274009178	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
718274009179	putative acyl-acceptor binding pocket; other site
718274009180	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
718274009181	acyl-activating enzyme (AAE) consensus motif; other site
718274009182	putative AMP binding site [chemical binding]; other site
718274009183	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
718274009184	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274009185	DNA binding site [nucleotide binding]
718274009186	domain linker motif; other site
718274009187	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
718274009188	dimerization interface (closed form) [polypeptide binding]; other site
718274009189	ligand binding site [chemical binding]; other site
718274009190	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718274009191	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274009192	DNA binding site [nucleotide binding]
718274009193	domain linker motif; other site
718274009194	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
718274009195	dimerization interface (closed form) [polypeptide binding]; other site
718274009196	ligand binding site [chemical binding]; other site
718274009197	diaminopimelate decarboxylase; Provisional; Region: PRK11165
718274009198	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
718274009199	active site
718274009200	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718274009201	substrate binding site [chemical binding]; other site
718274009202	catalytic residues [active]
718274009203	dimer interface [polypeptide binding]; other site
718274009204	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
718274009205	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274009206	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718274009207	dimerization interface [polypeptide binding]; other site
718274009208	putative racemase; Provisional; Region: PRK10200
718274009209	aspartate racemase; Region: asp_race; TIGR00035
718274009210	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
718274009211	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274009212	putative substrate translocation pore; other site
718274009213	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274009214	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
718274009215	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
718274009216	NADP binding site [chemical binding]; other site
718274009217	homodimer interface [polypeptide binding]; other site
718274009218	active site
718274009219	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
718274009220	putative acyltransferase; Provisional; Region: PRK05790
718274009221	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
718274009222	dimer interface [polypeptide binding]; other site
718274009223	active site
718274009224	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274009225	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274009226	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718274009227	dimerization interface [polypeptide binding]; other site
718274009228	Predicted membrane protein [Function unknown]; Region: COG4125
718274009229	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
718274009230	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
718274009231	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
718274009232	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
718274009233	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
718274009234	putative metal binding site [ion binding]; other site
718274009235	putative homodimer interface [polypeptide binding]; other site
718274009236	putative homotetramer interface [polypeptide binding]; other site
718274009237	putative homodimer-homodimer interface [polypeptide binding]; other site
718274009238	putative allosteric switch controlling residues; other site
718274009239	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
718274009240	transcriptional activator SprB; Provisional; Region: PRK15320
718274009241	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600
718274009242	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
718274009243	Fimbrial protein; Region: Fimbrial; pfam00419
718274009244	fimbrial chaperone protein StdC; Provisional; Region: PRK15254
718274009245	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274009246	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274009247	fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255
718274009248	PapC N-terminal domain; Region: PapC_N; pfam13954
718274009249	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
718274009250	PapC C-terminal domain; Region: PapC_C; pfam13953
718274009251	fimbrial protein StdA; Provisional; Region: PRK15210
718274009252	hypothetical protein; Provisional; Region: PRK10316
718274009253	YfdX protein; Region: YfdX; pfam10938
718274009254	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
718274009255	Transposase IS200 like; Region: Y1_Tnp; pfam01797
718274009256	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
718274009257	oligomeric interface; other site
718274009258	putative active site [active]
718274009259	homodimer interface [polypeptide binding]; other site
718274009260	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
718274009261	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
718274009262	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
718274009263	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718274009264	Peptidase family M23; Region: Peptidase_M23; pfam01551
718274009265	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
718274009266	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
718274009267	active site
718274009268	metal binding site [ion binding]; metal-binding site
718274009269	nudix motif; other site
718274009270	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
718274009271	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
718274009272	dimer interface [polypeptide binding]; other site
718274009273	putative anticodon binding site; other site
718274009274	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
718274009275	motif 1; other site
718274009276	active site
718274009277	motif 2; other site
718274009278	motif 3; other site
718274009279	This domain is found in peptide chain release factors; Region: PCRF; smart00937
718274009280	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
718274009281	RF-1 domain; Region: RF-1; pfam00472
718274009282	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
718274009283	DHH family; Region: DHH; pfam01368
718274009284	DHHA1 domain; Region: DHHA1; pfam02272
718274009285	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
718274009286	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
718274009287	dimerization domain [polypeptide binding]; other site
718274009288	dimer interface [polypeptide binding]; other site
718274009289	catalytic residues [active]
718274009290	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
718274009291	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
718274009292	active site
718274009293	Int/Topo IB signature motif; other site
718274009294	flavodoxin FldB; Provisional; Region: PRK12359
718274009295	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
718274009296	hypothetical protein; Provisional; Region: PRK10878
718274009297	putative global regulator; Reviewed; Region: PRK09559
718274009298	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
718274009299	hemolysin; Provisional; Region: PRK15087
718274009300	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
718274009301	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
718274009302	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
718274009303	beta-galactosidase; Region: BGL; TIGR03356
718274009304	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
718274009305	glycine dehydrogenase; Provisional; Region: PRK05367
718274009306	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
718274009307	tetramer interface [polypeptide binding]; other site
718274009308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274009309	catalytic residue [active]
718274009310	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
718274009311	tetramer interface [polypeptide binding]; other site
718274009312	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274009313	catalytic residue [active]
718274009314	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
718274009315	lipoyl attachment site [posttranslational modification]; other site
718274009316	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
718274009317	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
718274009318	oxidoreductase; Provisional; Region: PRK08013
718274009319	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
718274009320	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
718274009321	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
718274009322	proline aminopeptidase P II; Provisional; Region: PRK10879
718274009323	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
718274009324	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
718274009325	active site
718274009326	hypothetical protein; Reviewed; Region: PRK01736
718274009327	Z-ring-associated protein; Provisional; Region: PRK10972
718274009328	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
718274009329	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
718274009330	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
718274009331	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
718274009332	ligand binding site [chemical binding]; other site
718274009333	NAD binding site [chemical binding]; other site
718274009334	tetramer interface [polypeptide binding]; other site
718274009335	catalytic site [active]
718274009336	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
718274009337	L-serine binding site [chemical binding]; other site
718274009338	ACT domain interface; other site
718274009339	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
718274009340	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718274009341	active site
718274009342	dimer interface [polypeptide binding]; other site
718274009343	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
718274009344	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274009345	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
718274009346	putative dimerization interface [polypeptide binding]; other site
718274009347	Uncharacterized conserved protein [Function unknown]; Region: COG2968
718274009348	oxidative stress defense protein; Provisional; Region: PRK11087
718274009349	arginine exporter protein; Provisional; Region: PRK09304
718274009350	mechanosensitive channel MscS; Provisional; Region: PRK10334
718274009351	Mechanosensitive ion channel; Region: MS_channel; pfam00924
718274009352	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
718274009353	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
718274009354	active site
718274009355	intersubunit interface [polypeptide binding]; other site
718274009356	zinc binding site [ion binding]; other site
718274009357	Na+ binding site [ion binding]; other site
718274009358	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
718274009359	Phosphoglycerate kinase; Region: PGK; pfam00162
718274009360	substrate binding site [chemical binding]; other site
718274009361	hinge regions; other site
718274009362	ADP binding site [chemical binding]; other site
718274009363	catalytic site [active]
718274009364	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
718274009365	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
718274009366	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
718274009367	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
718274009368	trimer interface [polypeptide binding]; other site
718274009369	putative Zn binding site [ion binding]; other site
718274009370	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
718274009371	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
718274009372	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
718274009373	Walker A/P-loop; other site
718274009374	ATP binding site [chemical binding]; other site
718274009375	Q-loop/lid; other site
718274009376	ABC transporter signature motif; other site
718274009377	Walker B; other site
718274009378	D-loop; other site
718274009379	H-loop/switch region; other site
718274009380	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
718274009381	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
718274009382	Walker A/P-loop; other site
718274009383	ATP binding site [chemical binding]; other site
718274009384	Q-loop/lid; other site
718274009385	ABC transporter signature motif; other site
718274009386	Walker B; other site
718274009387	D-loop; other site
718274009388	H-loop/switch region; other site
718274009389	transketolase; Reviewed; Region: PRK12753
718274009390	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
718274009391	TPP-binding site [chemical binding]; other site
718274009392	dimer interface [polypeptide binding]; other site
718274009393	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
718274009394	PYR/PP interface [polypeptide binding]; other site
718274009395	dimer interface [polypeptide binding]; other site
718274009396	TPP binding site [chemical binding]; other site
718274009397	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
718274009398	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
718274009399	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
718274009400	agmatinase; Region: agmatinase; TIGR01230
718274009401	oligomer interface [polypeptide binding]; other site
718274009402	putative active site [active]
718274009403	Mn binding site [ion binding]; other site
718274009404	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
718274009405	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
718274009406	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
718274009407	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
718274009408	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
718274009409	putative NAD(P) binding site [chemical binding]; other site
718274009410	catalytic Zn binding site [ion binding]; other site
718274009411	structural Zn binding site [ion binding]; other site
718274009412	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
718274009413	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
718274009414	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
718274009415	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
718274009416	Transcriptional regulators [Transcription]; Region: FadR; COG2186
718274009417	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274009418	DNA-binding site [nucleotide binding]; DNA binding site
718274009419	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
718274009420	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
718274009421	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
718274009422	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
718274009423	dimer interface [polypeptide binding]; other site
718274009424	active site
718274009425	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718274009426	catalytic residues [active]
718274009427	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
718274009428	Virulence promoting factor; Region: YqgB; pfam11036
718274009429	Protein of unknown function (DUF2684); Region: DUF2684; pfam10885
718274009430	S-adenosylmethionine synthetase; Validated; Region: PRK05250
718274009431	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
718274009432	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
718274009433	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
718274009434	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
718274009435	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274009436	putative substrate translocation pore; other site
718274009437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274009438	hypothetical protein; Provisional; Region: PRK04860
718274009439	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
718274009440	DNA-specific endonuclease I; Provisional; Region: PRK15137
718274009441	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
718274009442	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
718274009443	RNA methyltransferase, RsmE family; Region: TIGR00046
718274009444	glutathione synthetase; Provisional; Region: PRK05246
718274009445	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
718274009446	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
718274009447	hypothetical protein; Validated; Region: PRK00228
718274009448	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
718274009449	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
718274009450	Transcriptional regulator [Transcription]; Region: IclR; COG1414
718274009451	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
718274009452	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
718274009453	Walker A motif; other site
718274009454	ATP binding site [chemical binding]; other site
718274009455	Walker B motif; other site
718274009456	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
718274009457	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718274009458	catalytic residue [active]
718274009459	YGGT family; Region: YGGT; pfam02325
718274009460	YGGT family; Region: YGGT; pfam02325
718274009461	hypothetical protein; Validated; Region: PRK05090
718274009462	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
718274009463	active site
718274009464	dimerization interface [polypeptide binding]; other site
718274009465	HemN family oxidoreductase; Provisional; Region: PRK05660
718274009466	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274009467	FeS/SAM binding site; other site
718274009468	HemN C-terminal domain; Region: HemN_C; pfam06969
718274009469	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
718274009470	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
718274009471	homodimer interface [polypeptide binding]; other site
718274009472	active site
718274009473	hypothetical protein; Provisional; Region: PRK10626
718274009474	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
718274009475	hypothetical protein; Provisional; Region: PRK11702
718274009476	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
718274009477	adenine DNA glycosylase; Provisional; Region: PRK10880
718274009478	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
718274009479	minor groove reading motif; other site
718274009480	helix-hairpin-helix signature motif; other site
718274009481	substrate binding pocket [chemical binding]; other site
718274009482	active site
718274009483	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
718274009484	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
718274009485	DNA binding and oxoG recognition site [nucleotide binding]
718274009486	oxidative damage protection protein; Provisional; Region: PRK05408
718274009487	murein transglycosylase C; Provisional; Region: mltC; PRK11671
718274009488	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
718274009489	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718274009490	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718274009491	catalytic residue [active]
718274009492	nucleoside transporter; Region: 2A0110; TIGR00889
718274009493	ornithine decarboxylase; Provisional; Region: PRK13578
718274009494	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
718274009495	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
718274009496	homodimer interface [polypeptide binding]; other site
718274009497	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274009498	catalytic residue [active]
718274009499	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
718274009500	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
718274009501	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
718274009502	dimer interface [polypeptide binding]; other site
718274009503	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
718274009504	metal binding site [ion binding]; metal-binding site
718274009505	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
718274009506	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
718274009507	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
718274009508	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
718274009509	putative active site [active]
718274009510	putative catalytic site [active]
718274009511	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
718274009512	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
718274009513	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274009514	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
718274009515	putative dimerization interface [polypeptide binding]; other site
718274009516	putative substrate binding pocket [chemical binding]; other site
718274009517	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
718274009518	Sulfatase; Region: Sulfatase; pfam00884
718274009519	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
718274009520	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274009521	FeS/SAM binding site; other site
718274009522	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
718274009523	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
718274009524	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274009525	DNA binding residues [nucleotide binding]
718274009526	dimerization interface [polypeptide binding]; other site
718274009527	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
718274009528	Amino acid permease; Region: AA_permease_2; pfam13520
718274009529	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
718274009530	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
718274009531	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
718274009532	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
718274009533	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
718274009534	NAD(P) binding site [chemical binding]; other site
718274009535	catalytic residues [active]
718274009536	DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128
718274009537	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
718274009538	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
718274009539	active site
718274009540	catalytic site [active]
718274009541	Zn binding site [ion binding]; other site
718274009542	tetramer interface [polypeptide binding]; other site
718274009543	Predicted amidohydrolase [General function prediction only]; Region: COG0388
718274009544	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
718274009545	putative active site [active]
718274009546	catalytic triad [active]
718274009547	putative dimer interface [polypeptide binding]; other site
718274009548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274009549	D-galactonate transporter; Region: 2A0114; TIGR00893
718274009550	putative substrate translocation pore; other site
718274009551	mannonate dehydratase; Provisional; Region: PRK03906
718274009552	mannonate dehydratase; Region: uxuA; TIGR00695
718274009553	D-mannonate oxidoreductase; Provisional; Region: PRK15037
718274009554	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
718274009555	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
718274009556	Glucuronate isomerase; Region: UxaC; pfam02614
718274009557	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
718274009558	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718274009559	dimer interface [polypeptide binding]; other site
718274009560	putative CheW interface [polypeptide binding]; other site
718274009561	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
718274009562	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
718274009563	CHAP domain; Region: CHAP; pfam05257
718274009564	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
718274009565	putative S-transferase; Provisional; Region: PRK11752
718274009566	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
718274009567	C-terminal domain interface [polypeptide binding]; other site
718274009568	GSH binding site (G-site) [chemical binding]; other site
718274009569	dimer interface [polypeptide binding]; other site
718274009570	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
718274009571	dimer interface [polypeptide binding]; other site
718274009572	N-terminal domain interface [polypeptide binding]; other site
718274009573	active site
718274009574	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
718274009575	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
718274009576	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
718274009577	putative ligand binding residues [chemical binding]; other site
718274009578	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
718274009579	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
718274009580	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
718274009581	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
718274009582	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
718274009583	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
718274009584	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
718274009585	putative substrate-binding site; other site
718274009586	nickel binding site [ion binding]; other site
718274009587	hydrogenase 2 large subunit; Provisional; Region: PRK10467
718274009588	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
718274009589	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
718274009590	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
718274009591	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
718274009592	4Fe-4S binding domain; Region: Fer4_6; pfam12837
718274009593	hydrogenase 2 small subunit; Provisional; Region: PRK10468
718274009594	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
718274009595	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
718274009596	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
718274009597	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
718274009598	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274009599	dimerization interface [polypeptide binding]; other site
718274009600	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718274009601	dimer interface [polypeptide binding]; other site
718274009602	putative CheW interface [polypeptide binding]; other site
718274009603	hypothetical protein; Provisional; Region: PRK05208
718274009604	oxidoreductase; Provisional; Region: PRK07985
718274009605	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
718274009606	NAD binding site [chemical binding]; other site
718274009607	metal binding site [ion binding]; metal-binding site
718274009608	active site
718274009609	biopolymer transport protein ExbD; Provisional; Region: PRK11267
718274009610	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
718274009611	biopolymer transport protein ExbB; Provisional; Region: PRK10414
718274009612	cystathionine beta-lyase; Provisional; Region: PRK08114
718274009613	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
718274009614	homodimer interface [polypeptide binding]; other site
718274009615	substrate-cofactor binding pocket; other site
718274009616	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274009617	catalytic residue [active]
718274009618	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
718274009619	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
718274009620	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
718274009621	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718274009622	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274009623	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274009624	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
718274009625	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
718274009626	dimer interface [polypeptide binding]; other site
718274009627	active site
718274009628	metal binding site [ion binding]; metal-binding site
718274009629	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
718274009630	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
718274009631	active site
718274009632	catalytic tetrad [active]
718274009633	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
718274009634	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
718274009635	transmembrane helices; other site
718274009636	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
718274009637	nucleotide binding site/active site [active]
718274009638	catalytic residue [active]
718274009639	hypothetical protein; Provisional; Region: PRK01254
718274009640	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
718274009641	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
718274009642	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
718274009643	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
718274009644	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
718274009645	DctM-like transporters; Region: DctM; pfam06808
718274009646	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
718274009647	FtsI repressor; Provisional; Region: PRK10883
718274009648	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
718274009649	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
718274009650	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
718274009651	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
718274009652	putative acyl-acceptor binding pocket; other site
718274009653	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
718274009654	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
718274009655	CAP-like domain; other site
718274009656	active site
718274009657	primary dimer interface [polypeptide binding]; other site
718274009658	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
718274009659	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718274009660	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274009661	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
718274009662	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
718274009663	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
718274009664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274009665	active site
718274009666	phosphorylation site [posttranslational modification]
718274009667	intermolecular recognition site; other site
718274009668	dimerization interface [polypeptide binding]; other site
718274009669	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274009670	DNA binding site [nucleotide binding]
718274009671	sensor protein QseC; Provisional; Region: PRK10337
718274009672	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
718274009673	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274009674	dimer interface [polypeptide binding]; other site
718274009675	phosphorylation site [posttranslational modification]
718274009676	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274009677	ATP binding site [chemical binding]; other site
718274009678	Mg2+ binding site [ion binding]; other site
718274009679	G-X-G motif; other site
718274009680	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
718274009681	Uncharacterized conserved protein [Function unknown]; Region: COG1359
718274009682	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
718274009683	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274009684	ATP binding site [chemical binding]; other site
718274009685	Mg2+ binding site [ion binding]; other site
718274009686	G-X-G motif; other site
718274009687	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
718274009688	anchoring element; other site
718274009689	dimer interface [polypeptide binding]; other site
718274009690	ATP binding site [chemical binding]; other site
718274009691	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
718274009692	active site
718274009693	metal binding site [ion binding]; metal-binding site
718274009694	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
718274009695	esterase YqiA; Provisional; Region: PRK11071
718274009696	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
718274009697	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
718274009698	active site
718274009699	metal binding site [ion binding]; metal-binding site
718274009700	hexamer interface [polypeptide binding]; other site
718274009701	putative dehydrogenase; Provisional; Region: PRK11039
718274009702	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
718274009703	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
718274009704	dimer interface [polypeptide binding]; other site
718274009705	ADP-ribose binding site [chemical binding]; other site
718274009706	active site
718274009707	nudix motif; other site
718274009708	metal binding site [ion binding]; metal-binding site
718274009709	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
718274009710	hypothetical protein; Provisional; Region: PRK11653
718274009711	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
718274009712	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
718274009713	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
718274009714	putative active site [active]
718274009715	metal binding site [ion binding]; metal-binding site
718274009716	zinc transporter ZupT; Provisional; Region: PRK04201
718274009717	ZIP Zinc transporter; Region: Zip; pfam02535
718274009718	Protein of unknown function (DUF4051); Region: DUF4051; pfam13260
718274009719	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
718274009720	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
718274009721	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
718274009722	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
718274009723	catalytic residues [active]
718274009724	hinge region; other site
718274009725	alpha helical domain; other site
718274009726	putative disulfide oxidoreductase; Provisional; Region: PRK04307
718274009727	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
718274009728	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
718274009729	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
718274009730	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
718274009731	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
718274009732	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
718274009733	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
718274009734	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
718274009735	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
718274009736	putative ribose interaction site [chemical binding]; other site
718274009737	putative ADP binding site [chemical binding]; other site
718274009738	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
718274009739	active site
718274009740	nucleotide binding site [chemical binding]; other site
718274009741	HIGH motif; other site
718274009742	KMSKS motif; other site
718274009743	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
718274009744	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
718274009745	metal binding triad; other site
718274009746	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
718274009747	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
718274009748	metal binding triad; other site
718274009749	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
718274009750	Uncharacterized conserved protein [Function unknown]; Region: COG3025
718274009751	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
718274009752	putative active site [active]
718274009753	putative metal binding residues [ion binding]; other site
718274009754	signature motif; other site
718274009755	putative triphosphate binding site [ion binding]; other site
718274009756	CHAD domain; Region: CHAD; pfam05235
718274009757	SH3 domain-containing protein; Provisional; Region: PRK10884
718274009758	Bacterial SH3 domain homologues; Region: SH3b; smart00287
718274009759	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
718274009760	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
718274009761	active site
718274009762	NTP binding site [chemical binding]; other site
718274009763	metal binding triad [ion binding]; metal-binding site
718274009764	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
718274009765	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718274009766	Zn2+ binding site [ion binding]; other site
718274009767	Mg2+ binding site [ion binding]; other site
718274009768	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
718274009769	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
718274009770	homooctamer interface [polypeptide binding]; other site
718274009771	active site
718274009772	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
718274009773	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
718274009774	UGMP family protein; Validated; Region: PRK09604
718274009775	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
718274009776	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
718274009777	DNA primase; Validated; Region: dnaG; PRK05667
718274009778	CHC2 zinc finger; Region: zf-CHC2; pfam01807
718274009779	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
718274009780	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
718274009781	active site
718274009782	metal binding site [ion binding]; metal-binding site
718274009783	interdomain interaction site; other site
718274009784	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
718274009785	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
718274009786	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
718274009787	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
718274009788	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
718274009789	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
718274009790	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718274009791	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
718274009792	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718274009793	DNA binding residues [nucleotide binding]
718274009794	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
718274009795	active site
718274009796	SUMO-1 interface [polypeptide binding]; other site
718274009797	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
718274009798	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
718274009799	FAD binding pocket [chemical binding]; other site
718274009800	FAD binding motif [chemical binding]; other site
718274009801	phosphate binding motif [ion binding]; other site
718274009802	NAD binding pocket [chemical binding]; other site
718274009803	Predicted transcriptional regulators [Transcription]; Region: COG1695
718274009804	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
718274009805	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
718274009806	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274009807	dimerization interface [polypeptide binding]; other site
718274009808	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718274009809	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718274009810	dimer interface [polypeptide binding]; other site
718274009811	putative CheW interface [polypeptide binding]; other site
718274009812	PAS fold; Region: PAS_3; pfam08447
718274009813	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
718274009814	putative active site [active]
718274009815	heme pocket [chemical binding]; other site
718274009816	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
718274009817	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718274009818	dimer interface [polypeptide binding]; other site
718274009819	putative CheW interface [polypeptide binding]; other site
718274009820	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
718274009821	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
718274009822	inhibitor-cofactor binding pocket; inhibition site
718274009823	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274009824	catalytic residue [active]
718274009825	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
718274009826	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
718274009827	active site
718274009828	FMN binding site [chemical binding]; other site
718274009829	2,4-decadienoyl-CoA binding site; other site
718274009830	catalytic residue [active]
718274009831	4Fe-4S cluster binding site [ion binding]; other site
718274009832	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
718274009833	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718274009834	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
718274009835	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274009836	S-adenosylmethionine binding site [chemical binding]; other site
718274009837	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
718274009838	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
718274009839	putative active site [active]
718274009840	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
718274009841	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
718274009842	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
718274009843	serine/threonine transporter SstT; Provisional; Region: PRK13628
718274009844	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
718274009845	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
718274009846	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
718274009847	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
718274009848	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
718274009849	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
718274009850	Predicted membrane protein [Function unknown]; Region: COG5393
718274009851	YqjK-like protein; Region: YqjK; pfam13997
718274009852	Predicted membrane protein [Function unknown]; Region: COG2259
718274009853	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
718274009854	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
718274009855	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
718274009856	putative dimer interface [polypeptide binding]; other site
718274009857	N-terminal domain interface [polypeptide binding]; other site
718274009858	putative substrate binding pocket (H-site) [chemical binding]; other site
718274009859	Predicted membrane protein [Function unknown]; Region: COG3152
718274009860	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274009861	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
718274009862	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
718274009863	dimerization interface [polypeptide binding]; other site
718274009864	Pirin-related protein [General function prediction only]; Region: COG1741
718274009865	Pirin; Region: Pirin; pfam02678
718274009866	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
718274009867	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
718274009868	serine transporter; Region: stp; TIGR00814
718274009869	L-serine dehydratase TdcG; Provisional; Region: PRK15040
718274009870	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
718274009871	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
718274009872	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
718274009873	Pyruvate formate lyase 1; Region: PFL1; cd01678
718274009874	coenzyme A binding site [chemical binding]; other site
718274009875	active site
718274009876	catalytic residues [active]
718274009877	glycine loop; other site
718274009878	propionate/acetate kinase; Provisional; Region: PRK12379
718274009879	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
718274009880	threonine/serine transporter TdcC; Provisional; Region: PRK13629
718274009881	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
718274009882	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
718274009883	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
718274009884	tetramer interface [polypeptide binding]; other site
718274009885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274009886	catalytic residue [active]
718274009887	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
718274009888	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274009889	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
718274009890	putative substrate binding pocket [chemical binding]; other site
718274009891	putative dimerization interface [polypeptide binding]; other site
718274009892	glycerate kinase I; Provisional; Region: PRK10342
718274009893	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
718274009894	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
718274009895	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
718274009896	galactarate dehydratase; Region: galactar-dH20; TIGR03248
718274009897	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
718274009898	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
718274009899	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718274009900	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
718274009901	substrate binding site [chemical binding]; other site
718274009902	ATP binding site [chemical binding]; other site
718274009903	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
718274009904	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
718274009905	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274009906	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
718274009907	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
718274009908	intersubunit interface [polypeptide binding]; other site
718274009909	active site
718274009910	zinc binding site [ion binding]; other site
718274009911	Na+ binding site [ion binding]; other site
718274009912	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
718274009913	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
718274009914	putative substrate binding site [chemical binding]; other site
718274009915	putative ATP binding site [chemical binding]; other site
718274009916	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
718274009917	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
718274009918	active site
718274009919	P-loop; other site
718274009920	phosphorylation site [posttranslational modification]
718274009921	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
718274009922	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718274009923	active site
718274009924	phosphorylation site [posttranslational modification]
718274009925	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718274009926	dimerization domain swap beta strand [polypeptide binding]; other site
718274009927	regulatory protein interface [polypeptide binding]; other site
718274009928	active site
718274009929	regulatory phosphorylation site [posttranslational modification]; other site
718274009930	D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052
718274009931	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718274009932	active site
718274009933	phosphorylation site [posttranslational modification]
718274009934	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
718274009935	active site
718274009936	P-loop; other site
718274009937	phosphorylation site [posttranslational modification]
718274009938	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
718274009939	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
718274009940	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
718274009941	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
718274009942	putative NAD(P) binding site [chemical binding]; other site
718274009943	catalytic Zn binding site [ion binding]; other site
718274009944	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
718274009945	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
718274009946	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274009947	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
718274009948	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
718274009949	putative SAM binding site [chemical binding]; other site
718274009950	putative homodimer interface [polypeptide binding]; other site
718274009951	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718274009952	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
718274009953	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
718274009954	putative ligand binding site [chemical binding]; other site
718274009955	TIGR00252 family protein; Region: TIGR00252
718274009956	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
718274009957	dimer interface [polypeptide binding]; other site
718274009958	active site
718274009959	outer membrane lipoprotein; Provisional; Region: PRK11023
718274009960	BON domain; Region: BON; pfam04972
718274009961	BON domain; Region: BON; pfam04972
718274009962	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
718274009963	NADH(P)-binding; Region: NAD_binding_10; pfam13460
718274009964	NAD binding site [chemical binding]; other site
718274009965	active site
718274009966	intracellular protease, PfpI family; Region: PfpI; TIGR01382
718274009967	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
718274009968	proposed catalytic triad [active]
718274009969	conserved cys residue [active]
718274009970	hypothetical protein; Provisional; Region: PRK03467
718274009971	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
718274009972	GIY-YIG motif/motif A; other site
718274009973	putative active site [active]
718274009974	putative metal binding site [ion binding]; other site
718274009975	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
718274009976	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274009977	Coenzyme A binding pocket [chemical binding]; other site
718274009978	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
718274009979	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
718274009980	Peptidase family U32; Region: Peptidase_U32; pfam01136
718274009981	putative protease; Provisional; Region: PRK15447
718274009982	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
718274009983	hypothetical protein; Provisional; Region: PRK10508
718274009984	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
718274009985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
718274009986	tryptophan permease; Provisional; Region: PRK10483
718274009987	aromatic amino acid transport protein; Region: araaP; TIGR00837
718274009988	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
718274009989	DEAD-like helicases superfamily; Region: DEXDc; smart00487
718274009990	ATP binding site [chemical binding]; other site
718274009991	Mg++ binding site [ion binding]; other site
718274009992	motif III; other site
718274009993	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274009994	nucleotide binding region [chemical binding]; other site
718274009995	ATP-binding site [chemical binding]; other site
718274009996	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
718274009997	putative RNA binding site [nucleotide binding]; other site
718274009998	lipoprotein NlpI; Provisional; Region: PRK11189
718274009999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718274010000	binding surface
718274010001	TPR motif; other site
718274010002	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
718274010003	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
718274010004	RNase E interface [polypeptide binding]; other site
718274010005	trimer interface [polypeptide binding]; other site
718274010006	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
718274010007	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
718274010008	RNase E interface [polypeptide binding]; other site
718274010009	trimer interface [polypeptide binding]; other site
718274010010	active site
718274010011	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
718274010012	putative nucleic acid binding region [nucleotide binding]; other site
718274010013	G-X-X-G motif; other site
718274010014	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
718274010015	RNA binding site [nucleotide binding]; other site
718274010016	domain interface; other site
718274010017	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
718274010018	16S/18S rRNA binding site [nucleotide binding]; other site
718274010019	S13e-L30e interaction site [polypeptide binding]; other site
718274010020	25S rRNA binding site [nucleotide binding]; other site
718274010021	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
718274010022	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
718274010023	RNA binding site [nucleotide binding]; other site
718274010024	active site
718274010025	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
718274010026	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
718274010027	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
718274010028	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
718274010029	translation initiation factor IF-2; Region: IF-2; TIGR00487
718274010030	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
718274010031	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
718274010032	G1 box; other site
718274010033	putative GEF interaction site [polypeptide binding]; other site
718274010034	GTP/Mg2+ binding site [chemical binding]; other site
718274010035	Switch I region; other site
718274010036	G2 box; other site
718274010037	G3 box; other site
718274010038	Switch II region; other site
718274010039	G4 box; other site
718274010040	G5 box; other site
718274010041	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
718274010042	Translation-initiation factor 2; Region: IF-2; pfam11987
718274010043	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
718274010044	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
718274010045	NusA N-terminal domain; Region: NusA_N; pfam08529
718274010046	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
718274010047	RNA binding site [nucleotide binding]; other site
718274010048	homodimer interface [polypeptide binding]; other site
718274010049	NusA-like KH domain; Region: KH_5; pfam13184
718274010050	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
718274010051	G-X-X-G motif; other site
718274010052	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
718274010053	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
718274010054	ribosome maturation protein RimP; Reviewed; Region: PRK00092
718274010055	hypothetical protein; Provisional; Region: PRK14641
718274010056	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
718274010057	putative oligomer interface [polypeptide binding]; other site
718274010058	putative RNA binding site [nucleotide binding]; other site
718274010059	argininosuccinate synthase; Validated; Region: PRK05370
718274010060	argininosuccinate synthase; Provisional; Region: PRK13820
718274010061	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
718274010062	Preprotein translocase SecG subunit; Region: SecG; pfam03840
718274010063	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
718274010064	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
718274010065	active site
718274010066	substrate binding site [chemical binding]; other site
718274010067	metal binding site [ion binding]; metal-binding site
718274010068	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
718274010069	dihydropteroate synthase; Region: DHPS; TIGR01496
718274010070	substrate binding pocket [chemical binding]; other site
718274010071	dimer interface [polypeptide binding]; other site
718274010072	inhibitor binding site; inhibition site
718274010073	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
718274010074	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274010075	Walker A motif; other site
718274010076	ATP binding site [chemical binding]; other site
718274010077	Walker B motif; other site
718274010078	arginine finger; other site
718274010079	Peptidase family M41; Region: Peptidase_M41; pfam01434
718274010080	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
718274010081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274010082	S-adenosylmethionine binding site [chemical binding]; other site
718274010083	RNA-binding protein YhbY; Provisional; Region: PRK10343
718274010084	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
718274010085	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
718274010086	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
718274010087	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
718274010088	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
718274010089	GTPase CgtA; Reviewed; Region: obgE; PRK12298
718274010090	GTP1/OBG; Region: GTP1_OBG; pfam01018
718274010091	Obg GTPase; Region: Obg; cd01898
718274010092	G1 box; other site
718274010093	GTP/Mg2+ binding site [chemical binding]; other site
718274010094	Switch I region; other site
718274010095	G2 box; other site
718274010096	G3 box; other site
718274010097	Switch II region; other site
718274010098	G4 box; other site
718274010099	G5 box; other site
718274010100	potential frameshift: common BLAST hit: gi|197247798|ref|YP_002148227.1| transporter
718274010101	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
718274010102	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
718274010103	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
718274010104	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
718274010105	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
718274010106	substrate binding pocket [chemical binding]; other site
718274010107	chain length determination region; other site
718274010108	substrate-Mg2+ binding site; other site
718274010109	catalytic residues [active]
718274010110	aspartate-rich region 1; other site
718274010111	active site lid residues [active]
718274010112	aspartate-rich region 2; other site
718274010113	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
718274010114	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
718274010115	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
718274010116	hinge; other site
718274010117	active site
718274010118	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
718274010119	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
718274010120	anti sigma factor interaction site; other site
718274010121	regulatory phosphorylation site [posttranslational modification]; other site
718274010122	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
718274010123	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
718274010124	mce related protein; Region: MCE; pfam02470
718274010125	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
718274010126	conserved hypothetical integral membrane protein; Region: TIGR00056
718274010127	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
718274010128	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
718274010129	Walker A/P-loop; other site
718274010130	ATP binding site [chemical binding]; other site
718274010131	Q-loop/lid; other site
718274010132	ABC transporter signature motif; other site
718274010133	Walker B; other site
718274010134	D-loop; other site
718274010135	H-loop/switch region; other site
718274010136	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
718274010137	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
718274010138	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
718274010139	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
718274010140	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
718274010141	putative active site [active]
718274010142	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
718274010143	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
718274010144	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
718274010145	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
718274010146	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
718274010147	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
718274010148	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
718274010149	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
718274010150	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
718274010151	Walker A/P-loop; other site
718274010152	ATP binding site [chemical binding]; other site
718274010153	Q-loop/lid; other site
718274010154	ABC transporter signature motif; other site
718274010155	Walker B; other site
718274010156	D-loop; other site
718274010157	H-loop/switch region; other site
718274010158	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
718274010159	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
718274010160	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
718274010161	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
718274010162	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
718274010163	30S subunit binding site; other site
718274010164	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718274010165	active site
718274010166	phosphorylation site [posttranslational modification]
718274010167	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
718274010168	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718274010169	dimerization domain swap beta strand [polypeptide binding]; other site
718274010170	regulatory protein interface [polypeptide binding]; other site
718274010171	active site
718274010172	regulatory phosphorylation site [posttranslational modification]; other site
718274010173	hypothetical protein; Provisional; Region: PRK10345
718274010174	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
718274010175	Transglycosylase; Region: Transgly; cl17702
718274010176	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
718274010177	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
718274010178	conserved cys residue [active]
718274010179	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
718274010180	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
718274010181	putative active site [active]
718274010182	heme pocket [chemical binding]; other site
718274010183	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274010184	dimer interface [polypeptide binding]; other site
718274010185	phosphorylation site [posttranslational modification]
718274010186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274010187	ATP binding site [chemical binding]; other site
718274010188	Mg2+ binding site [ion binding]; other site
718274010189	G-X-G motif; other site
718274010190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274010191	active site
718274010192	phosphorylation site [posttranslational modification]
718274010193	intermolecular recognition site; other site
718274010194	dimerization interface [polypeptide binding]; other site
718274010195	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
718274010196	putative binding surface; other site
718274010197	active site
718274010198	radical SAM protein, TIGR01212 family; Region: TIGR01212
718274010199	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274010200	FeS/SAM binding site; other site
718274010201	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
718274010202	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
718274010203	active site
718274010204	dimer interface [polypeptide binding]; other site
718274010205	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
718274010206	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
718274010207	active site
718274010208	FMN binding site [chemical binding]; other site
718274010209	substrate binding site [chemical binding]; other site
718274010210	3Fe-4S cluster binding site [ion binding]; other site
718274010211	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
718274010212	domain interface; other site
718274010213	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
718274010214	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718274010215	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274010216	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
718274010217	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
718274010218	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
718274010219	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
718274010220	Na binding site [ion binding]; other site
718274010221	putative substrate binding site [chemical binding]; other site
718274010222	cytosine deaminase; Provisional; Region: PRK09230
718274010223	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
718274010224	active site
718274010225	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
718274010226	N-acetylmannosamine kinase; Provisional; Region: PRK05082
718274010227	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718274010228	nucleotide binding site [chemical binding]; other site
718274010229	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
718274010230	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
718274010231	putative active site cavity [active]
718274010232	putative sialic acid transporter; Provisional; Region: PRK03893
718274010233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274010234	putative substrate translocation pore; other site
718274010235	N-acetylneuraminate lyase; Provisional; Region: PRK04147
718274010236	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
718274010237	inhibitor site; inhibition site
718274010238	active site
718274010239	dimer interface [polypeptide binding]; other site
718274010240	catalytic residue [active]
718274010241	transcriptional regulator NanR; Provisional; Region: PRK03837
718274010242	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274010243	DNA-binding site [nucleotide binding]; DNA binding site
718274010244	FCD domain; Region: FCD; pfam07729
718274010245	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
718274010246	stringent starvation protein A; Provisional; Region: sspA; PRK09481
718274010247	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
718274010248	C-terminal domain interface [polypeptide binding]; other site
718274010249	putative GSH binding site (G-site) [chemical binding]; other site
718274010250	dimer interface [polypeptide binding]; other site
718274010251	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
718274010252	dimer interface [polypeptide binding]; other site
718274010253	N-terminal domain interface [polypeptide binding]; other site
718274010254	Family of unknown function (DUF695); Region: DUF695; pfam05117
718274010255	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
718274010256	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
718274010257	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
718274010258	23S rRNA interface [nucleotide binding]; other site
718274010259	L3 interface [polypeptide binding]; other site
718274010260	Predicted ATPase [General function prediction only]; Region: COG1485
718274010261	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
718274010262	hypothetical protein; Provisional; Region: PRK11677
718274010263	serine endoprotease; Provisional; Region: PRK10139
718274010264	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
718274010265	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
718274010266	protein binding site [polypeptide binding]; other site
718274010267	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
718274010268	serine endoprotease; Provisional; Region: PRK10898
718274010269	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
718274010270	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
718274010271	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
718274010272	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
718274010273	oxaloacetate decarboxylase; Provisional; Region: PRK14040
718274010274	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
718274010275	active site
718274010276	catalytic residues [active]
718274010277	metal binding site [ion binding]; metal-binding site
718274010278	homodimer binding site [polypeptide binding]; other site
718274010279	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
718274010280	carboxyltransferase (CT) interaction site; other site
718274010281	biotinylation site [posttranslational modification]; other site
718274010282	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
718274010283	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
718274010284	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
718274010285	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
718274010286	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
718274010287	transmembrane helices; other site
718274010288	Transcriptional regulators [Transcription]; Region: GntR; COG1802
718274010289	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274010290	DNA-binding site [nucleotide binding]; DNA binding site
718274010291	FCD domain; Region: FCD; pfam07729
718274010292	Transcriptional regulators [Transcription]; Region: GntR; COG1802
718274010293	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274010294	DNA-binding site [nucleotide binding]; DNA binding site
718274010295	malate dehydrogenase; Provisional; Region: PRK05086
718274010296	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
718274010297	NAD binding site [chemical binding]; other site
718274010298	dimerization interface [polypeptide binding]; other site
718274010299	Substrate binding site [chemical binding]; other site
718274010300	arginine repressor; Provisional; Region: PRK05066
718274010301	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
718274010302	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
718274010303	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
718274010304	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
718274010305	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
718274010306	RNAase interaction site [polypeptide binding]; other site
718274010307	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
718274010308	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
718274010309	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
718274010310	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718274010311	HlyD family secretion protein; Region: HlyD_3; pfam13437
718274010312	efflux system membrane protein; Provisional; Region: PRK11594
718274010313	transcriptional regulator; Provisional; Region: PRK10632
718274010314	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274010315	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
718274010316	putative effector binding pocket; other site
718274010317	dimerization interface [polypeptide binding]; other site
718274010318	protease TldD; Provisional; Region: tldD; PRK10735
718274010319	hypothetical protein; Provisional; Region: PRK10899
718274010320	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
718274010321	ribonuclease G; Provisional; Region: PRK11712
718274010322	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
718274010323	homodimer interface [polypeptide binding]; other site
718274010324	oligonucleotide binding site [chemical binding]; other site
718274010325	Maf-like protein; Region: Maf; pfam02545
718274010326	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
718274010327	active site
718274010328	dimer interface [polypeptide binding]; other site
718274010329	rod shape-determining protein MreD; Provisional; Region: PRK11060
718274010330	rod shape-determining protein MreC; Region: mreC; TIGR00219
718274010331	rod shape-determining protein MreC; Region: MreC; pfam04085
718274010332	rod shape-determining protein MreB; Provisional; Region: PRK13927
718274010333	MreB and similar proteins; Region: MreB_like; cd10225
718274010334	nucleotide binding site [chemical binding]; other site
718274010335	Mg binding site [ion binding]; other site
718274010336	putative protofilament interaction site [polypeptide binding]; other site
718274010337	RodZ interaction site [polypeptide binding]; other site
718274010338	regulatory protein CsrD; Provisional; Region: PRK11059
718274010339	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718274010340	metal binding site [ion binding]; metal-binding site
718274010341	active site
718274010342	I-site; other site
718274010343	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274010344	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
718274010345	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
718274010346	NADP binding site [chemical binding]; other site
718274010347	dimer interface [polypeptide binding]; other site
718274010348	TMAO/DMSO reductase; Reviewed; Region: PRK05363
718274010349	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
718274010350	Moco binding site; other site
718274010351	metal coordination site [ion binding]; other site
718274010352	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
718274010353	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
718274010354	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
718274010355	carboxyltransferase (CT) interaction site; other site
718274010356	biotinylation site [posttranslational modification]; other site
718274010357	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
718274010358	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
718274010359	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
718274010360	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
718274010361	hypothetical protein; Provisional; Region: PRK10633
718274010362	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
718274010363	Na binding site [ion binding]; other site
718274010364	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
718274010365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
718274010366	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
718274010367	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
718274010368	FMN binding site [chemical binding]; other site
718274010369	active site
718274010370	catalytic residues [active]
718274010371	substrate binding site [chemical binding]; other site
718274010372	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
718274010373	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
718274010374	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
718274010375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274010376	DNA methylase; Region: N6_N4_Mtase; pfam01555
718274010377	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
718274010378	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
718274010379	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
718274010380	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
718274010381	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718274010382	metal binding site [ion binding]; metal-binding site
718274010383	active site
718274010384	I-site; other site
718274010385	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274010386	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
718274010387	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274010388	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
718274010389	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
718274010390	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718274010391	HlyD family secretion protein; Region: HlyD_3; pfam13437
718274010392	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
718274010393	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
718274010394	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
718274010395	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
718274010396	trimer interface [polypeptide binding]; other site
718274010397	putative metal binding site [ion binding]; other site
718274010398	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
718274010399	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
718274010400	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
718274010401	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
718274010402	shikimate binding site; other site
718274010403	NAD(P) binding site [chemical binding]; other site
718274010404	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
718274010405	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
718274010406	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
718274010407	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
718274010408	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
718274010409	hypothetical protein; Validated; Region: PRK03430
718274010410	hypothetical protein; Provisional; Region: PRK10736
718274010411	DNA protecting protein DprA; Region: dprA; TIGR00732
718274010412	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
718274010413	active site
718274010414	catalytic residues [active]
718274010415	metal binding site [ion binding]; metal-binding site
718274010416	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
718274010417	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
718274010418	putative active site [active]
718274010419	substrate binding site [chemical binding]; other site
718274010420	putative cosubstrate binding site; other site
718274010421	catalytic site [active]
718274010422	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
718274010423	substrate binding site [chemical binding]; other site
718274010424	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
718274010425	putative RNA binding site [nucleotide binding]; other site
718274010426	16S rRNA methyltransferase B; Provisional; Region: PRK10901
718274010427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274010428	S-adenosylmethionine binding site [chemical binding]; other site
718274010429	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
718274010430	TrkA-N domain; Region: TrkA_N; pfam02254
718274010431	TrkA-C domain; Region: TrkA_C; pfam02080
718274010432	TrkA-N domain; Region: TrkA_N; pfam02254
718274010433	TrkA-C domain; Region: TrkA_C; pfam02080
718274010434	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
718274010435	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
718274010436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
718274010437	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
718274010438	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
718274010439	DNA binding residues [nucleotide binding]
718274010440	dimer interface [polypeptide binding]; other site
718274010441	metal binding site [ion binding]; metal-binding site
718274010442	hypothetical protein; Provisional; Region: PRK10203
718274010443	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
718274010444	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
718274010445	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
718274010446	alphaNTD homodimer interface [polypeptide binding]; other site
718274010447	alphaNTD - beta interaction site [polypeptide binding]; other site
718274010448	alphaNTD - beta' interaction site [polypeptide binding]; other site
718274010449	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
718274010450	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
718274010451	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
718274010452	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718274010453	RNA binding surface [nucleotide binding]; other site
718274010454	30S ribosomal protein S11; Validated; Region: PRK05309
718274010455	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
718274010456	30S ribosomal protein S13; Region: bact_S13; TIGR03631
718274010457	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
718274010458	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
718274010459	SecY translocase; Region: SecY; pfam00344
718274010460	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
718274010461	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
718274010462	23S rRNA binding site [nucleotide binding]; other site
718274010463	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
718274010464	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
718274010465	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
718274010466	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
718274010467	23S rRNA interface [nucleotide binding]; other site
718274010468	5S rRNA interface [nucleotide binding]; other site
718274010469	L27 interface [polypeptide binding]; other site
718274010470	L5 interface [polypeptide binding]; other site
718274010471	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
718274010472	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
718274010473	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
718274010474	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
718274010475	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
718274010476	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
718274010477	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
718274010478	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
718274010479	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
718274010480	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
718274010481	RNA binding site [nucleotide binding]; other site
718274010482	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
718274010483	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
718274010484	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
718274010485	23S rRNA interface [nucleotide binding]; other site
718274010486	putative translocon interaction site; other site
718274010487	signal recognition particle (SRP54) interaction site; other site
718274010488	L23 interface [polypeptide binding]; other site
718274010489	trigger factor interaction site; other site
718274010490	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
718274010491	23S rRNA interface [nucleotide binding]; other site
718274010492	5S rRNA interface [nucleotide binding]; other site
718274010493	putative antibiotic binding site [chemical binding]; other site
718274010494	L25 interface [polypeptide binding]; other site
718274010495	L27 interface [polypeptide binding]; other site
718274010496	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
718274010497	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
718274010498	G-X-X-G motif; other site
718274010499	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
718274010500	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
718274010501	protein-rRNA interface [nucleotide binding]; other site
718274010502	putative translocon binding site; other site
718274010503	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
718274010504	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
718274010505	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
718274010506	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
718274010507	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
718274010508	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
718274010509	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
718274010510	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
718274010511	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
718274010512	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
718274010513	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
718274010514	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
718274010515	heme binding site [chemical binding]; other site
718274010516	ferroxidase pore; other site
718274010517	ferroxidase diiron center [ion binding]; other site
718274010518	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
718274010519	elongation factor Tu; Reviewed; Region: PRK00049
718274010520	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
718274010521	G1 box; other site
718274010522	GEF interaction site [polypeptide binding]; other site
718274010523	GTP/Mg2+ binding site [chemical binding]; other site
718274010524	Switch I region; other site
718274010525	G2 box; other site
718274010526	G3 box; other site
718274010527	Switch II region; other site
718274010528	G4 box; other site
718274010529	G5 box; other site
718274010530	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
718274010531	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
718274010532	Antibiotic Binding Site [chemical binding]; other site
718274010533	elongation factor G; Reviewed; Region: PRK00007
718274010534	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
718274010535	G1 box; other site
718274010536	putative GEF interaction site [polypeptide binding]; other site
718274010537	GTP/Mg2+ binding site [chemical binding]; other site
718274010538	Switch I region; other site
718274010539	G2 box; other site
718274010540	G3 box; other site
718274010541	Switch II region; other site
718274010542	G4 box; other site
718274010543	G5 box; other site
718274010544	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
718274010545	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
718274010546	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
718274010547	30S ribosomal protein S7; Validated; Region: PRK05302
718274010548	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
718274010549	S17 interaction site [polypeptide binding]; other site
718274010550	S8 interaction site; other site
718274010551	16S rRNA interaction site [nucleotide binding]; other site
718274010552	streptomycin interaction site [chemical binding]; other site
718274010553	23S rRNA interaction site [nucleotide binding]; other site
718274010554	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
718274010555	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
718274010556	sulfur relay protein TusC; Validated; Region: PRK00211
718274010557	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
718274010558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
718274010559	YheO-like PAS domain; Region: PAS_6; pfam08348
718274010560	HTH domain; Region: HTH_22; pfam13309
718274010561	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
718274010562	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
718274010563	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
718274010564	phi X174 lysis protein; Provisional; Region: PRK02793
718274010565	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
718274010566	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
718274010567	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
718274010568	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
718274010569	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
718274010570	TrkA-N domain; Region: TrkA_N; pfam02254
718274010571	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
718274010572	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
718274010573	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274010574	Walker A/P-loop; other site
718274010575	ATP binding site [chemical binding]; other site
718274010576	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718274010577	ABC transporter signature motif; other site
718274010578	Walker B; other site
718274010579	D-loop; other site
718274010580	ABC transporter; Region: ABC_tran_2; pfam12848
718274010581	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718274010582	putative monooxygenase; Provisional; Region: PRK11118
718274010583	putative hydrolase; Provisional; Region: PRK10985
718274010584	hypothetical protein; Provisional; Region: PRK04966
718274010585	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
718274010586	active site
718274010587	hypothetical protein; Provisional; Region: PRK10738
718274010588	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
718274010589	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
718274010590	ligand binding site [chemical binding]; other site
718274010591	flexible hinge region; other site
718274010592	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
718274010593	putative switch regulator; other site
718274010594	non-specific DNA interactions [nucleotide binding]; other site
718274010595	DNA binding site [nucleotide binding]
718274010596	sequence specific DNA binding site [nucleotide binding]; other site
718274010597	putative cAMP binding site [chemical binding]; other site
718274010598	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
718274010599	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
718274010600	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
718274010601	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
718274010602	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
718274010603	inhibitor-cofactor binding pocket; inhibition site
718274010604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274010605	catalytic residue [active]
718274010606	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
718274010607	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
718274010608	glutamine binding [chemical binding]; other site
718274010609	catalytic triad [active]
718274010610	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
718274010611	cell filamentation protein Fic; Provisional; Region: PRK10347
718274010612	hypothetical protein; Provisional; Region: PRK10204
718274010613	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
718274010614	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
718274010615	substrate binding site [chemical binding]; other site
718274010616	putative transporter; Provisional; Region: PRK03699
718274010617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274010618	putative substrate translocation pore; other site
718274010619	nitrite reductase subunit NirD; Provisional; Region: PRK14989
718274010620	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274010621	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
718274010622	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
718274010623	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
718274010624	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
718274010625	nitrite transporter NirC; Provisional; Region: PRK11562
718274010626	siroheme synthase; Provisional; Region: cysG; PRK10637
718274010627	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
718274010628	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
718274010629	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
718274010630	active site
718274010631	SAM binding site [chemical binding]; other site
718274010632	homodimer interface [polypeptide binding]; other site
718274010633	Autotransporter beta-domain; Region: Autotransporter; pfam03797
718274010634	Transposase IS200 like; Region: Y1_Tnp; pfam01797
718274010635	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
718274010636	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
718274010637	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
718274010638	active site
718274010639	HIGH motif; other site
718274010640	dimer interface [polypeptide binding]; other site
718274010641	KMSKS motif; other site
718274010642	phosphoglycolate phosphatase; Provisional; Region: PRK13222
718274010643	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274010644	motif II; other site
718274010645	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
718274010646	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
718274010647	substrate binding site [chemical binding]; other site
718274010648	hexamer interface [polypeptide binding]; other site
718274010649	metal binding site [ion binding]; metal-binding site
718274010650	DNA adenine methylase; Provisional; Region: PRK10904
718274010651	cell division protein DamX; Validated; Region: PRK10905
718274010652	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
718274010653	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
718274010654	active site
718274010655	dimer interface [polypeptide binding]; other site
718274010656	metal binding site [ion binding]; metal-binding site
718274010657	shikimate kinase; Reviewed; Region: aroK; PRK00131
718274010658	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
718274010659	ADP binding site [chemical binding]; other site
718274010660	magnesium binding site [ion binding]; other site
718274010661	putative shikimate binding site; other site
718274010662	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
718274010663	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
718274010664	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
718274010665	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
718274010666	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
718274010667	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
718274010668	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
718274010669	Transglycosylase; Region: Transgly; pfam00912
718274010670	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
718274010671	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
718274010672	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
718274010673	ADP-ribose binding site [chemical binding]; other site
718274010674	dimer interface [polypeptide binding]; other site
718274010675	active site
718274010676	nudix motif; other site
718274010677	metal binding site [ion binding]; metal-binding site
718274010678	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
718274010679	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
718274010680	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274010681	motif II; other site
718274010682	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718274010683	RNA binding surface [nucleotide binding]; other site
718274010684	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
718274010685	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
718274010686	dimerization interface [polypeptide binding]; other site
718274010687	domain crossover interface; other site
718274010688	redox-dependent activation switch; other site
718274010689	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
718274010690	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
718274010691	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
718274010692	active site
718274010693	substrate-binding site [chemical binding]; other site
718274010694	metal-binding site [ion binding]
718274010695	ATP binding site [chemical binding]; other site
718274010696	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
718274010697	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274010698	dimerization interface [polypeptide binding]; other site
718274010699	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274010700	dimer interface [polypeptide binding]; other site
718274010701	phosphorylation site [posttranslational modification]
718274010702	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274010703	ATP binding site [chemical binding]; other site
718274010704	G-X-G motif; other site
718274010705	osmolarity response regulator; Provisional; Region: ompR; PRK09468
718274010706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274010707	active site
718274010708	phosphorylation site [posttranslational modification]
718274010709	intermolecular recognition site; other site
718274010710	dimerization interface [polypeptide binding]; other site
718274010711	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274010712	DNA binding site [nucleotide binding]
718274010713	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
718274010714	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
718274010715	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
718274010716	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
718274010717	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
718274010718	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
718274010719	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
718274010720	RNA binding site [nucleotide binding]; other site
718274010721	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
718274010722	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
718274010723	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
718274010724	G1 box; other site
718274010725	GTP/Mg2+ binding site [chemical binding]; other site
718274010726	Switch I region; other site
718274010727	G2 box; other site
718274010728	G3 box; other site
718274010729	Switch II region; other site
718274010730	G4 box; other site
718274010731	G5 box; other site
718274010732	Nucleoside recognition; Region: Gate; pfam07670
718274010733	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
718274010734	Nucleoside recognition; Region: Gate; pfam07670
718274010735	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
718274010736	hypothetical protein; Provisional; Region: PRK09956
718274010737	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
718274010738	carboxylesterase BioH; Provisional; Region: PRK10349
718274010739	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
718274010740	DNA utilization protein GntX; Provisional; Region: PRK11595
718274010741	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718274010742	active site
718274010743	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
718274010744	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
718274010745	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
718274010746	high-affinity gluconate transporter; Provisional; Region: PRK14984
718274010747	gluconate transporter; Region: gntP; TIGR00791
718274010748	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
718274010749	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
718274010750	maltodextrin phosphorylase; Provisional; Region: PRK14985
718274010751	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
718274010752	homodimer interface [polypeptide binding]; other site
718274010753	active site pocket [active]
718274010754	transcriptional regulator MalT; Provisional; Region: PRK04841
718274010755	AAA ATPase domain; Region: AAA_16; pfam13191
718274010756	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274010757	DNA binding residues [nucleotide binding]
718274010758	dimerization interface [polypeptide binding]; other site
718274010759	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
718274010760	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
718274010761	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
718274010762	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
718274010763	putative active site [active]
718274010764	adenylation catalytic residue [active]
718274010765	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
718274010766	hypothetical protein; Reviewed; Region: PRK09588
718274010767	TROVE domain; Region: TROVE; pfam05731
718274010768	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
718274010769	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
718274010770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274010771	Walker A motif; other site
718274010772	ATP binding site [chemical binding]; other site
718274010773	Walker B motif; other site
718274010774	arginine finger; other site
718274010775	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
718274010776	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
718274010777	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274010778	intramembrane serine protease GlpG; Provisional; Region: PRK10907
718274010779	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
718274010780	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
718274010781	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
718274010782	active site residue [active]
718274010783	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
718274010784	hypothetical protein; Provisional; Region: PRK09781
718274010785	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
718274010786	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
718274010787	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
718274010788	dimer interface [polypeptide binding]; other site
718274010789	active site
718274010790	metal binding site [ion binding]; metal-binding site
718274010791	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274010792	D-galactonate transporter; Region: 2A0114; TIGR00893
718274010793	putative substrate translocation pore; other site
718274010794	Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129
718274010795	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
718274010796	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
718274010797	inhibitor site; inhibition site
718274010798	active site
718274010799	dimer interface [polypeptide binding]; other site
718274010800	catalytic residue [active]
718274010801	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
718274010802	Transcriptional regulator [Transcription]; Region: IclR; COG1414
718274010803	Bacterial transcriptional regulator; Region: IclR; pfam01614
718274010804	glycogen phosphorylase; Provisional; Region: PRK14986
718274010805	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
718274010806	homodimer interface [polypeptide binding]; other site
718274010807	active site pocket [active]
718274010808	glycogen synthase; Provisional; Region: glgA; PRK00654
718274010809	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
718274010810	ADP-binding pocket [chemical binding]; other site
718274010811	homodimer interface [polypeptide binding]; other site
718274010812	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
718274010813	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
718274010814	ligand binding site; other site
718274010815	oligomer interface; other site
718274010816	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
718274010817	dimer interface [polypeptide binding]; other site
718274010818	N-terminal domain interface [polypeptide binding]; other site
718274010819	sulfate 1 binding site; other site
718274010820	glycogen debranching enzyme; Provisional; Region: PRK03705
718274010821	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
718274010822	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
718274010823	active site
718274010824	catalytic site [active]
718274010825	glycogen branching enzyme; Provisional; Region: PRK05402
718274010826	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
718274010827	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
718274010828	active site
718274010829	catalytic site [active]
718274010830	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
718274010831	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
718274010832	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
718274010833	low affinity gluconate transporter; Provisional; Region: PRK10472
718274010834	gluconate transporter; Region: gntP; TIGR00791
718274010835	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
718274010836	ATP-binding site [chemical binding]; other site
718274010837	Gluconate-6-phosphate binding site [chemical binding]; other site
718274010838	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
718274010839	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274010840	DNA binding site [nucleotide binding]
718274010841	domain linker motif; other site
718274010842	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
718274010843	putative ligand binding site [chemical binding]; other site
718274010844	putative dimerization interface [polypeptide binding]; other site
718274010845	Pirin-related protein [General function prediction only]; Region: COG1741
718274010846	Pirin; Region: Pirin; pfam02678
718274010847	putative oxidoreductase; Provisional; Region: PRK10206
718274010848	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
718274010849	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
718274010850	putative acetyltransferase YhhY; Provisional; Region: PRK10140
718274010851	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274010852	Coenzyme A binding pocket [chemical binding]; other site
718274010853	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
718274010854	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
718274010855	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718274010856	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
718274010857	substrate binding site [chemical binding]; other site
718274010858	dimer interface [polypeptide binding]; other site
718274010859	ATP binding site [chemical binding]; other site
718274010860	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
718274010861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
718274010862	Protein of unknown function, DUF606; Region: DUF606; pfam04657
718274010863	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
718274010864	active site
718274010865	substrate binding pocket [chemical binding]; other site
718274010866	homodimer interaction site [polypeptide binding]; other site
718274010867	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
718274010868	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
718274010869	hypothetical protein; Provisional; Region: PRK10350
718274010870	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
718274010871	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
718274010872	putative active site [active]
718274010873	catalytic site [active]
718274010874	putative metal binding site [ion binding]; other site
718274010875	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
718274010876	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
718274010877	Walker A/P-loop; other site
718274010878	ATP binding site [chemical binding]; other site
718274010879	Q-loop/lid; other site
718274010880	ABC transporter signature motif; other site
718274010881	Walker B; other site
718274010882	D-loop; other site
718274010883	H-loop/switch region; other site
718274010884	TOBE domain; Region: TOBE_2; pfam08402
718274010885	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718274010886	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274010887	dimer interface [polypeptide binding]; other site
718274010888	conserved gate region; other site
718274010889	ABC-ATPase subunit interface; other site
718274010890	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
718274010891	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274010892	dimer interface [polypeptide binding]; other site
718274010893	conserved gate region; other site
718274010894	putative PBP binding loops; other site
718274010895	ABC-ATPase subunit interface; other site
718274010896	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
718274010897	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
718274010898	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
718274010899	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
718274010900	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
718274010901	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
718274010902	Walker A/P-loop; other site
718274010903	ATP binding site [chemical binding]; other site
718274010904	Q-loop/lid; other site
718274010905	ABC transporter signature motif; other site
718274010906	Walker B; other site
718274010907	D-loop; other site
718274010908	H-loop/switch region; other site
718274010909	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
718274010910	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
718274010911	Walker A/P-loop; other site
718274010912	ATP binding site [chemical binding]; other site
718274010913	Q-loop/lid; other site
718274010914	ABC transporter signature motif; other site
718274010915	Walker B; other site
718274010916	D-loop; other site
718274010917	H-loop/switch region; other site
718274010918	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
718274010919	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
718274010920	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
718274010921	TM-ABC transporter signature motif; other site
718274010922	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718274010923	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
718274010924	TM-ABC transporter signature motif; other site
718274010925	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
718274010926	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
718274010927	dimerization interface [polypeptide binding]; other site
718274010928	ligand binding site [chemical binding]; other site
718274010929	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
718274010930	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
718274010931	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
718274010932	dimerization interface [polypeptide binding]; other site
718274010933	ligand binding site [chemical binding]; other site
718274010934	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
718274010935	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
718274010936	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
718274010937	DNA binding residues [nucleotide binding]
718274010938	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
718274010939	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
718274010940	cell division protein FtsE; Provisional; Region: PRK10908
718274010941	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274010942	Walker A/P-loop; other site
718274010943	ATP binding site [chemical binding]; other site
718274010944	Q-loop/lid; other site
718274010945	ABC transporter signature motif; other site
718274010946	Walker B; other site
718274010947	D-loop; other site
718274010948	H-loop/switch region; other site
718274010949	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
718274010950	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
718274010951	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
718274010952	P loop; other site
718274010953	GTP binding site [chemical binding]; other site
718274010954	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
718274010955	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274010956	S-adenosylmethionine binding site [chemical binding]; other site
718274010957	hypothetical protein; Provisional; Region: PRK10910
718274010958	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
718274010959	Predicted membrane protein [Function unknown]; Region: COG3714
718274010960	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
718274010961	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718274010962	metal-binding site [ion binding]
718274010963	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718274010964	Soluble P-type ATPase [General function prediction only]; Region: COG4087
718274010965	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
718274010966	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
718274010967	dimer interface [polypeptide binding]; other site
718274010968	ligand binding site [chemical binding]; other site
718274010969	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274010970	dimerization interface [polypeptide binding]; other site
718274010971	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718274010972	dimer interface [polypeptide binding]; other site
718274010973	putative CheW interface [polypeptide binding]; other site
718274010974	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
718274010975	CPxP  motif; other site
718274010976	hypothetical protein; Provisional; Region: PRK11212
718274010977	hypothetical protein; Provisional; Region: PRK11615
718274010978	major facilitator superfamily transporter; Provisional; Region: PRK05122
718274010979	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274010980	putative substrate translocation pore; other site
718274010981	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
718274010982	Domain of unknown function DUF20; Region: UPF0118; pfam01594
718274010983	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
718274010984	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
718274010985	nickel responsive regulator; Provisional; Region: PRK02967
718274010986	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
718274010987	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
718274010988	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
718274010989	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
718274010990	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
718274010991	Walker A/P-loop; other site
718274010992	ATP binding site [chemical binding]; other site
718274010993	Q-loop/lid; other site
718274010994	ABC transporter signature motif; other site
718274010995	Walker B; other site
718274010996	D-loop; other site
718274010997	H-loop/switch region; other site
718274010998	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
718274010999	Walker A/P-loop; other site
718274011000	ATP binding site [chemical binding]; other site
718274011001	Q-loop/lid; other site
718274011002	ABC transporter signature motif; other site
718274011003	Walker B; other site
718274011004	D-loop; other site
718274011005	H-loop/switch region; other site
718274011006	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
718274011007	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
718274011008	HlyD family secretion protein; Region: HlyD; pfam00529
718274011009	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718274011010	HlyD family secretion protein; Region: HlyD_3; pfam13437
718274011011	Predicted flavoproteins [General function prediction only]; Region: COG2081
718274011012	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718274011013	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
718274011014	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
718274011015	universal stress protein UspB; Provisional; Region: PRK04960
718274011016	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
718274011017	Ligand Binding Site [chemical binding]; other site
718274011018	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
718274011019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274011020	putative substrate translocation pore; other site
718274011021	POT family; Region: PTR2; pfam00854
718274011022	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274011023	S-adenosylmethionine binding site [chemical binding]; other site
718274011024	oligopeptidase A; Provisional; Region: PRK10911
718274011025	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
718274011026	active site
718274011027	Zn binding site [ion binding]; other site
718274011028	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
718274011029	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
718274011030	active site
718274011031	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
718274011032	glutathione reductase; Validated; Region: PRK06116
718274011033	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718274011034	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274011035	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
718274011036	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
718274011037	active site
718274011038	homodimer interface [polypeptide binding]; other site
718274011039	homotetramer interface [polypeptide binding]; other site
718274011040	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
718274011041	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
718274011042	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274011043	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274011044	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274011045	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
718274011046	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
718274011047	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
718274011048	putative active site [active]
718274011049	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
718274011050	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274011051	DNA-binding site [nucleotide binding]; DNA binding site
718274011052	UTRA domain; Region: UTRA; pfam07702
718274011053	trehalase; Provisional; Region: treF; PRK13270
718274011054	Trehalase; Region: Trehalase; pfam01204
718274011055	Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772
718274011056	catalytic residue [active]
718274011057	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
718274011058	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274011059	DNA binding residues [nucleotide binding]
718274011060	dimerization interface [polypeptide binding]; other site
718274011061	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274011062	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274011063	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
718274011064	putative effector binding pocket; other site
718274011065	putative dimerization interface [polypeptide binding]; other site
718274011066	inner membrane protein YhjD; Region: TIGR00766
718274011067	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274011068	metabolite-proton symporter; Region: 2A0106; TIGR00883
718274011069	putative substrate translocation pore; other site
718274011070	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
718274011071	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
718274011072	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274011073	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718274011074	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
718274011075	substrate binding site [chemical binding]; other site
718274011076	ATP binding site [chemical binding]; other site
718274011077	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
718274011078	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
718274011079	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
718274011080	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
718274011081	putative diguanylate cyclase; Provisional; Region: PRK13561
718274011082	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718274011083	metal binding site [ion binding]; metal-binding site
718274011084	active site
718274011085	I-site; other site
718274011086	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274011087	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
718274011088	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
718274011089	TPR motif; other site
718274011090	binding surface
718274011091	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718274011092	TPR motif; other site
718274011093	binding surface
718274011094	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
718274011095	binding surface
718274011096	TPR motif; other site
718274011097	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
718274011098	endo-1,4-D-glucanase; Provisional; Region: PRK11097
718274011099	cellulose synthase regulator protein; Provisional; Region: PRK11114
718274011100	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
718274011101	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718274011102	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
718274011103	DXD motif; other site
718274011104	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718274011105	PilZ domain; Region: PilZ; pfam07238
718274011106	cell division protein; Provisional; Region: PRK10037
718274011107	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
718274011108	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
718274011109	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
718274011110	Protein of unknown function (DUF2636); Region: DUF2636; pfam11120
718274011111	cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368
718274011112	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
718274011113	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
718274011114	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
718274011115	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
718274011116	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
718274011117	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
718274011118	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718274011119	Walker A/P-loop; other site
718274011120	ATP binding site [chemical binding]; other site
718274011121	Q-loop/lid; other site
718274011122	ABC transporter signature motif; other site
718274011123	Walker B; other site
718274011124	D-loop; other site
718274011125	H-loop/switch region; other site
718274011126	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
718274011127	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
718274011128	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
718274011129	Walker A/P-loop; other site
718274011130	ATP binding site [chemical binding]; other site
718274011131	Q-loop/lid; other site
718274011132	ABC transporter signature motif; other site
718274011133	Walker B; other site
718274011134	D-loop; other site
718274011135	H-loop/switch region; other site
718274011136	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
718274011137	dipeptide transporter; Provisional; Region: PRK10913
718274011138	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
718274011139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274011140	dimer interface [polypeptide binding]; other site
718274011141	conserved gate region; other site
718274011142	putative PBP binding loops; other site
718274011143	ABC-ATPase subunit interface; other site
718274011144	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
718274011145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274011146	dimer interface [polypeptide binding]; other site
718274011147	conserved gate region; other site
718274011148	putative PBP binding loops; other site
718274011149	ABC-ATPase subunit interface; other site
718274011150	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
718274011151	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
718274011152	peptide binding site [polypeptide binding]; other site
718274011153	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
718274011154	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
718274011155	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
718274011156	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718274011157	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274011158	DNA binding site [nucleotide binding]
718274011159	domain linker motif; other site
718274011160	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287
718274011161	putative dimerization interface [polypeptide binding]; other site
718274011162	putative ligand binding site [chemical binding]; other site
718274011163	phosphoethanolamine transferase; Provisional; Region: PRK11560
718274011164	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
718274011165	Sulfatase; Region: Sulfatase; pfam00884
718274011166	long polar fimbrial protein LpfE; Provisional; Region: PRK15205
718274011167	long polar fimbrial protein LpfD; Provisional; Region: PRK15206
718274011168	long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207
718274011169	PapC N-terminal domain; Region: PapC_N; pfam13954
718274011170	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
718274011171	PapC C-terminal domain; Region: PapC_C; pfam13953
718274011172	long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208
718274011173	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274011174	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274011175	long polar fimbrial protein LpfA; Provisional; Region: PRK15209
718274011176	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
718274011177	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
718274011178	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274011179	Coenzyme A binding pocket [chemical binding]; other site
718274011180	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
718274011181	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
718274011182	molybdopterin cofactor binding site [chemical binding]; other site
718274011183	substrate binding site [chemical binding]; other site
718274011184	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
718274011185	molybdopterin cofactor binding site; other site
718274011186	putative outer membrane lipoprotein; Provisional; Region: PRK10510
718274011187	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
718274011188	ligand binding site [chemical binding]; other site
718274011189	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
718274011190	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
718274011191	dimerization interface [polypeptide binding]; other site
718274011192	ligand binding site [chemical binding]; other site
718274011193	NADP binding site [chemical binding]; other site
718274011194	catalytic site [active]
718274011195	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
718274011196	Predicted transcriptional regulator [Transcription]; Region: COG2944
718274011197	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274011198	salt bridge; other site
718274011199	non-specific DNA binding site [nucleotide binding]; other site
718274011200	sequence-specific DNA binding site [nucleotide binding]; other site
718274011201	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
718274011202	DNA-binding site [nucleotide binding]; DNA binding site
718274011203	RNA-binding motif; other site
718274011204	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
718274011205	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
718274011206	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
718274011207	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274011208	Coenzyme A binding pocket [chemical binding]; other site
718274011209	Integrase core domain; Region: rve; pfam00665
718274011210	Integrase core domain; Region: rve_2; pfam13333
718274011211	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
718274011212	DALR anticodon binding domain; Region: DALR_1; pfam05746
718274011213	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
718274011214	dimer interface [polypeptide binding]; other site
718274011215	motif 1; other site
718274011216	active site
718274011217	motif 2; other site
718274011218	motif 3; other site
718274011219	YsaB-like lipoprotein; Region: YsaB; pfam13983
718274011220	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
718274011221	Acyltransferase family; Region: Acyl_transf_3; pfam01757
718274011222	Predicted membrane protein [Function unknown]; Region: COG4682
718274011223	yiaA/B two helix domain; Region: YiaAB; cl01759
718274011224	yiaA/B two helix domain; Region: YiaAB; cl01759
718274011225	xylulokinase; Provisional; Region: PRK15027
718274011226	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
718274011227	N- and C-terminal domain interface [polypeptide binding]; other site
718274011228	active site
718274011229	MgATP binding site [chemical binding]; other site
718274011230	catalytic site [active]
718274011231	metal binding site [ion binding]; metal-binding site
718274011232	xylulose binding site [chemical binding]; other site
718274011233	homodimer interface [polypeptide binding]; other site
718274011234	xylose isomerase; Provisional; Region: PRK05474
718274011235	xylose isomerase; Region: xylose_isom_A; TIGR02630
718274011236	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
718274011237	putative dimerization interface [polypeptide binding]; other site
718274011238	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718274011239	putative ligand binding site [chemical binding]; other site
718274011240	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274011241	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718274011242	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274011243	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
718274011244	hypothetical protein; Provisional; Region: PRK10356
718274011245	alpha-amylase; Reviewed; Region: malS; PRK09505
718274011246	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
718274011247	active site
718274011248	catalytic site [active]
718274011249	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
718274011250	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718274011251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274011252	homodimer interface [polypeptide binding]; other site
718274011253	catalytic residue [active]
718274011254	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
718274011255	Transcriptional regulator [Transcription]; Region: IclR; COG1414
718274011256	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
718274011257	Bacterial transcriptional regulator; Region: IclR; pfam01614
718274011258	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
718274011259	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
718274011260	2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877
718274011261	L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060
718274011262	DctM-like transporters; Region: DctM; pfam06808
718274011263	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
718274011264	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
718274011265	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
718274011266	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
718274011267	putative N- and C-terminal domain interface [polypeptide binding]; other site
718274011268	putative active site [active]
718274011269	MgATP binding site [chemical binding]; other site
718274011270	catalytic site [active]
718274011271	metal binding site [ion binding]; metal-binding site
718274011272	putative xylulose binding site [chemical binding]; other site
718274011273	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
718274011274	active site
718274011275	dimer interface [polypeptide binding]; other site
718274011276	magnesium binding site [ion binding]; other site
718274011277	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
718274011278	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
718274011279	AP (apurinic/apyrimidinic) site pocket; other site
718274011280	DNA interaction; other site
718274011281	Metal-binding active site; metal-binding site
718274011282	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
718274011283	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
718274011284	intersubunit interface [polypeptide binding]; other site
718274011285	active site
718274011286	Zn2+ binding site [ion binding]; other site
718274011287	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718274011288	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
718274011289	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274011290	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
718274011291	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
718274011292	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
718274011293	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
718274011294	NAD(P) binding site [chemical binding]; other site
718274011295	catalytic residues [active]
718274011296	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
718274011297	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
718274011298	nucleotide binding site [chemical binding]; other site
718274011299	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
718274011300	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
718274011301	G1 box; other site
718274011302	putative GEF interaction site [polypeptide binding]; other site
718274011303	GTP/Mg2+ binding site [chemical binding]; other site
718274011304	Switch I region; other site
718274011305	G2 box; other site
718274011306	G3 box; other site
718274011307	Switch II region; other site
718274011308	G4 box; other site
718274011309	G5 box; other site
718274011310	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
718274011311	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
718274011312	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
718274011313	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
718274011314	selenocysteine synthase; Provisional; Region: PRK04311
718274011315	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
718274011316	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
718274011317	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718274011318	catalytic residue [active]
718274011319	putative glutathione S-transferase; Provisional; Region: PRK10357
718274011320	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
718274011321	putative C-terminal domain interface [polypeptide binding]; other site
718274011322	putative GSH binding site (G-site) [chemical binding]; other site
718274011323	putative dimer interface [polypeptide binding]; other site
718274011324	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
718274011325	dimer interface [polypeptide binding]; other site
718274011326	N-terminal domain interface [polypeptide binding]; other site
718274011327	putative substrate binding pocket (H-site) [chemical binding]; other site
718274011328	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
718274011329	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
718274011330	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
718274011331	active site
718274011332	P-loop; other site
718274011333	phosphorylation site [posttranslational modification]
718274011334	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718274011335	active site
718274011336	phosphorylation site [posttranslational modification]
718274011337	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
718274011338	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
718274011339	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
718274011340	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
718274011341	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
718274011342	hypothetical protein; Provisional; Region: PRK11020
718274011343	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
718274011344	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
718274011345	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
718274011346	trimer interface [polypeptide binding]; other site
718274011347	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
718274011348	Haemagglutinin; Region: HIM; pfam05662
718274011349	Haemagglutinin; Region: HIM; pfam05662
718274011350	YadA-like C-terminal region; Region: YadA; pfam03895
718274011351	L-lactate permease; Provisional; Region: PRK10420
718274011352	glycolate transporter; Provisional; Region: PRK09695
718274011353	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
718274011354	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274011355	DNA-binding site [nucleotide binding]; DNA binding site
718274011356	FCD domain; Region: FCD; pfam07729
718274011357	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
718274011358	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
718274011359	active site
718274011360	substrate binding site [chemical binding]; other site
718274011361	FMN binding site [chemical binding]; other site
718274011362	putative catalytic residues [active]
718274011363	putative rRNA methylase; Provisional; Region: PRK10358
718274011364	Transcriptional regulators [Transcription]; Region: PurR; COG1609
718274011365	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274011366	DNA binding site [nucleotide binding]
718274011367	domain linker motif; other site
718274011368	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
718274011369	putative dimerization interface [polypeptide binding]; other site
718274011370	putative ligand binding site [chemical binding]; other site
718274011371	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
718274011372	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
718274011373	active site pocket [active]
718274011374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274011375	D-galactonate transporter; Region: 2A0114; TIGR00893
718274011376	putative substrate translocation pore; other site
718274011377	serine acetyltransferase; Provisional; Region: cysE; PRK11132
718274011378	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
718274011379	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
718274011380	trimer interface [polypeptide binding]; other site
718274011381	active site
718274011382	substrate binding site [chemical binding]; other site
718274011383	CoA binding site [chemical binding]; other site
718274011384	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
718274011385	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
718274011386	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
718274011387	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
718274011388	SecA binding site; other site
718274011389	Preprotein binding site; other site
718274011390	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
718274011391	GSH binding site [chemical binding]; other site
718274011392	catalytic residues [active]
718274011393	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
718274011394	active site residue [active]
718274011395	phosphoglyceromutase; Provisional; Region: PRK05434
718274011396	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
718274011397	AmiB activator; Provisional; Region: PRK11637
718274011398	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
718274011399	Peptidase family M23; Region: Peptidase_M23; pfam01551
718274011400	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
718274011401	NodB motif; other site
718274011402	putative active site [active]
718274011403	putative catalytic site [active]
718274011404	Zn binding site [ion binding]; other site
718274011405	putative glycosyl transferase; Provisional; Region: PRK10073
718274011406	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
718274011407	active site
718274011408	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
718274011409	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
718274011410	NAD(P) binding site [chemical binding]; other site
718274011411	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
718274011412	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
718274011413	substrate-cofactor binding pocket; other site
718274011414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274011415	catalytic residue [active]
718274011416	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
718274011417	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
718274011418	NADP binding site [chemical binding]; other site
718274011419	homopentamer interface [polypeptide binding]; other site
718274011420	substrate binding site [chemical binding]; other site
718274011421	active site
718274011422	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
718274011423	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
718274011424	putative active site [active]
718274011425	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
718274011426	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
718274011427	putative active site [active]
718274011428	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
718274011429	O-antigen ligase RfaL; Provisional; Region: PRK15487
718274011430	lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484
718274011431	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
718274011432	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
718274011433	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176
718274011434	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
718274011435	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
718274011436	Ligand binding site; other site
718274011437	metal-binding site
718274011438	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
718274011439	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
718274011440	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
718274011441	Ligand binding site; other site
718274011442	metal-binding site
718274011443	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
718274011444	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
718274011445	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
718274011446	putative ADP-binding pocket [chemical binding]; other site
718274011447	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718274011448	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
718274011449	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
718274011450	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
718274011451	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
718274011452	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
718274011453	putative active site [active]
718274011454	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
718274011455	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
718274011456	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
718274011457	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
718274011458	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
718274011459	active site
718274011460	(T/H)XGH motif; other site
718274011461	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
718274011462	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
718274011463	DNA binding site [nucleotide binding]
718274011464	catalytic residue [active]
718274011465	H2TH interface [polypeptide binding]; other site
718274011466	putative catalytic residues [active]
718274011467	turnover-facilitating residue; other site
718274011468	intercalation triad [nucleotide binding]; other site
718274011469	8OG recognition residue [nucleotide binding]; other site
718274011470	putative reading head residues; other site
718274011471	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
718274011472	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
718274011473	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
718274011474	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
718274011475	hypothetical protein; Reviewed; Region: PRK00024
718274011476	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
718274011477	MPN+ (JAMM) motif; other site
718274011478	Zinc-binding site [ion binding]; other site
718274011479	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
718274011480	Flavoprotein; Region: Flavoprotein; pfam02441
718274011481	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
718274011482	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
718274011483	trimer interface [polypeptide binding]; other site
718274011484	active site
718274011485	division inhibitor protein; Provisional; Region: slmA; PRK09480
718274011486	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274011487	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
718274011488	active site
718274011489	ribonuclease PH; Reviewed; Region: rph; PRK00173
718274011490	Ribonuclease PH; Region: RNase_PH_bact; cd11362
718274011491	hexamer interface [polypeptide binding]; other site
718274011492	active site
718274011493	hypothetical protein; Provisional; Region: PRK11820
718274011494	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
718274011495	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
718274011496	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274011497	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274011498	dimerization interface [polypeptide binding]; other site
718274011499	LysR substrate binding domain; Region: LysR_substrate; pfam03466
718274011500	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
718274011501	Predicted membrane protein [Function unknown]; Region: COG2860
718274011502	UPF0126 domain; Region: UPF0126; pfam03458
718274011503	UPF0126 domain; Region: UPF0126; pfam03458
718274011504	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
718274011505	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
718274011506	nucleotide binding pocket [chemical binding]; other site
718274011507	K-X-D-G motif; other site
718274011508	catalytic site [active]
718274011509	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
718274011510	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
718274011511	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
718274011512	catalytic site [active]
718274011513	G-X2-G-X-G-K; other site
718274011514	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
718274011515	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
718274011516	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
718274011517	Zn2+ binding site [ion binding]; other site
718274011518	Mg2+ binding site [ion binding]; other site
718274011519	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
718274011520	synthetase active site [active]
718274011521	NTP binding site [chemical binding]; other site
718274011522	metal binding site [ion binding]; metal-binding site
718274011523	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
718274011524	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
718274011525	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
718274011526	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
718274011527	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
718274011528	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
718274011529	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
718274011530	generic binding surface II; other site
718274011531	ssDNA binding site; other site
718274011532	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718274011533	ATP binding site [chemical binding]; other site
718274011534	putative Mg++ binding site [ion binding]; other site
718274011535	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274011536	nucleotide binding region [chemical binding]; other site
718274011537	ATP-binding site [chemical binding]; other site
718274011538	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
718274011539	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
718274011540	AsmA family; Region: AsmA; pfam05170
718274011541	putative alpha-glucosidase; Provisional; Region: PRK10658
718274011542	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
718274011543	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
718274011544	active site
718274011545	homotrimer interface [polypeptide binding]; other site
718274011546	catalytic site [active]
718274011547	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
718274011548	putative transporter; Provisional; Region: PRK11462
718274011549	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
718274011550	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274011551	AAA domain; Region: AAA_23; pfam13476
718274011552	Walker A/P-loop; other site
718274011553	ATP binding site [chemical binding]; other site
718274011554	AAA domain; Region: AAA_21; pfam13304
718274011555	Methyltransferase domain; Region: Methyltransf_27; pfam13708
718274011556	Virulence protein [General function prediction only]; Region: COG3943
718274011557	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
718274011558	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
718274011559	Transposase; Region: HTH_Tnp_1; pfam01527
718274011560	autotransport protein MisL; Provisional; Region: PRK15313
718274011561	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
718274011562	Autotransporter beta-domain; Region: Autotransporter; pfam03797
718274011563	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
718274011564	DNA binding site [nucleotide binding]
718274011565	Isochorismatase family; Region: Isochorismatase; pfam00857
718274011566	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
718274011567	catalytic triad [active]
718274011568	dimer interface [polypeptide binding]; other site
718274011569	conserved cis-peptide bond; other site
718274011570	magnesium-transporting ATPase; Provisional; Region: PRK15122
718274011571	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
718274011572	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718274011573	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
718274011574	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274011575	motif II; other site
718274011576	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
718274011577	magnesium transport protein MgtC; Provisional; Region: PRK15385
718274011578	MgtC family; Region: MgtC; pfam02308
718274011579	EamA-like transporter family; Region: EamA; pfam00892
718274011580	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
718274011581	EamA-like transporter family; Region: EamA; pfam00892
718274011582	hypothetical protein; Provisional; Region: PRK09956
718274011583	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
718274011584	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
718274011585	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
718274011586	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
718274011587	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
718274011588	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
718274011589	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
718274011590	active site
718274011591	phosphorylation site [posttranslational modification]
718274011592	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
718274011593	active pocket/dimerization site; other site
718274011594	active site
718274011595	phosphorylation site [posttranslational modification]
718274011596	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
718274011597	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274011598	Walker A motif; other site
718274011599	ATP binding site [chemical binding]; other site
718274011600	Walker B motif; other site
718274011601	arginine finger; other site
718274011602	Transcriptional antiterminator [Transcription]; Region: COG3933
718274011603	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
718274011604	active site
718274011605	active pocket/dimerization site; other site
718274011606	phosphorylation site [posttranslational modification]
718274011607	PRD domain; Region: PRD; pfam00874
718274011608	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
718274011609	beta-galactosidase; Region: BGL; TIGR03356
718274011610	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
718274011611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274011612	putative substrate translocation pore; other site
718274011613	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737
718274011614	Predicted transcriptional regulator [Transcription]; Region: COG2944
718274011615	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274011616	non-specific DNA binding site [nucleotide binding]; other site
718274011617	salt bridge; other site
718274011618	sequence-specific DNA binding site [nucleotide binding]; other site
718274011619	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718274011620	dimerization domain swap beta strand [polypeptide binding]; other site
718274011621	regulatory protein interface [polypeptide binding]; other site
718274011622	active site
718274011623	regulatory phosphorylation site [posttranslational modification]; other site
718274011624	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
718274011625	intersubunit interface [polypeptide binding]; other site
718274011626	active site
718274011627	zinc binding site [ion binding]; other site
718274011628	Na+ binding site [ion binding]; other site
718274011629	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
718274011630	uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774
718274011631	putative N- and C-terminal domain interface [polypeptide binding]; other site
718274011632	putative active site [active]
718274011633	putative MgATP binding site [chemical binding]; other site
718274011634	catalytic site [active]
718274011635	metal binding site [ion binding]; metal-binding site
718274011636	putative carbohydrate binding site [chemical binding]; other site
718274011637	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
718274011638	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
718274011639	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
718274011640	active site
718274011641	P-loop; other site
718274011642	phosphorylation site [posttranslational modification]
718274011643	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718274011644	active site
718274011645	phosphorylation site [posttranslational modification]
718274011646	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
718274011647	UTRA domain; Region: UTRA; pfam07702
718274011648	Salmonella T000240 genomic island GI-DT12
718274011649	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274011650	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274011651	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274011652	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
718274011653	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
718274011654	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
718274011655	oligomeric interface; other site
718274011656	putative active site [active]
718274011657	homodimer interface [polypeptide binding]; other site
718274011658	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274011659	AAA domain; Region: AAA_21; pfam13304
718274011660	Walker A/P-loop; other site
718274011661	ATP binding site [chemical binding]; other site
718274011662	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
718274011663	putative active site [active]
718274011664	putative metal-binding site [ion binding]; other site
718274011665	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
718274011666	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
718274011667	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274011668	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274011669	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274011670	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
718274011671	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
718274011672	N-terminal plug; other site
718274011673	ligand-binding site [chemical binding]; other site
718274011674	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
718274011675	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718274011676	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
718274011677	IucA / IucC family; Region: IucA_IucC; pfam04183
718274011678	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
718274011679	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
718274011680	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
718274011681	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
718274011682	IucA / IucC family; Region: IucA_IucC; pfam04183
718274011683	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
718274011684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274011685	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718274011686	putative substrate translocation pore; other site
718274011687	chromosome condensation membrane protein; Provisional; Region: PRK14196
718274011688	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
718274011689	substrate binding pocket [chemical binding]; other site
718274011690	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
718274011691	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718274011692	ABC-ATPase subunit  interface; other site
718274011693	dimer interface [polypeptide binding]; other site
718274011694	putative PBP binding regions; other site
718274011695	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
718274011696	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
718274011697	ABC-ATPase subunit  interface; other site
718274011698	dimer interface [polypeptide binding]; other site
718274011699	putative PBP binding regions; other site
718274011700	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
718274011701	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
718274011702	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
718274011703	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
718274011704	metal binding site [ion binding]; metal-binding site
718274011705	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274011706	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274011707	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274011708	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
718274011709	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
718274011710	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
718274011711	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
718274011712	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
718274011713	active site
718274011714	catalytic residues [active]
718274011715	DNA binding site [nucleotide binding]
718274011716	Int/Topo IB signature motif; other site
718274011717	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
718274011718	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
718274011719	Predicted transcriptional regulator [Transcription]; Region: COG3905
718274011720	Transcriptional regulator [Transcription]; Region: IclR; COG1414
718274011721	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
718274011722	Bacterial transcriptional regulator; Region: IclR; pfam01614
718274011723	2-keto-3-deoxygluconate permease; Region: KdgT; cl14653
718274011724	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
718274011725	homotrimer interaction site [polypeptide binding]; other site
718274011726	putative active site [active]
718274011727	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
718274011728	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
718274011729	inhibitor site; inhibition site
718274011730	active site
718274011731	dimer interface [polypeptide binding]; other site
718274011732	catalytic residue [active]
718274011733	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
718274011734	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
718274011735	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
718274011736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274011737	dimer interface [polypeptide binding]; other site
718274011738	conserved gate region; other site
718274011739	putative PBP binding loops; other site
718274011740	ABC-ATPase subunit interface; other site
718274011741	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718274011742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274011743	dimer interface [polypeptide binding]; other site
718274011744	conserved gate region; other site
718274011745	putative PBP binding loops; other site
718274011746	ABC-ATPase subunit interface; other site
718274011747	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
718274011748	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
718274011749	active site
718274011750	metal binding site [ion binding]; metal-binding site
718274011751	hexamer interface [polypeptide binding]; other site
718274011752	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
718274011753	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
718274011754	Walker A/P-loop; other site
718274011755	ATP binding site [chemical binding]; other site
718274011756	Q-loop/lid; other site
718274011757	ABC transporter signature motif; other site
718274011758	Walker B; other site
718274011759	D-loop; other site
718274011760	H-loop/switch region; other site
718274011761	TOBE domain; Region: TOBE_2; pfam08402
718274011762	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
718274011763	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
718274011764	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
718274011765	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
718274011766	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
718274011767	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
718274011768	Integrase core domain; Region: rve; pfam00665
718274011769	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
718274011770	catalytic core [active]
718274011771	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
718274011772	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
718274011773	catalytic residues [active]
718274011774	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
718274011775	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
718274011776	Walker A/P-loop; other site
718274011777	ATP binding site [chemical binding]; other site
718274011778	Q-loop/lid; other site
718274011779	ABC transporter signature motif; other site
718274011780	Walker B; other site
718274011781	D-loop; other site
718274011782	H-loop/switch region; other site
718274011783	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718274011784	FtsX-like permease family; Region: FtsX; pfam02687
718274011785	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
718274011786	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
718274011787	FtsX-like permease family; Region: FtsX; pfam02687
718274011788	Predicted membrane protein [Function unknown]; Region: COG4393
718274011789	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
718274011790	Uncharacterized conserved protein [Function unknown]; Region: COG3350
718274011791	Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470
718274011792	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
718274011793	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
718274011794	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
718274011795	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
718274011796	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
718274011797	catalytic residues [active]
718274011798	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
718274011799	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274011800	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274011801	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274011802	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
718274011803	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
718274011804	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274011805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274011806	Major Facilitator Superfamily; Region: MFS_1; pfam07690
718274011807	putative substrate translocation pore; other site
718274011808	tetracycline repressor protein TetR; Provisional; Region: PRK13756
718274011809	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274011810	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
718274011811	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718274011812	dimerization interface [polypeptide binding]; other site
718274011813	putative DNA binding site [nucleotide binding]; other site
718274011814	putative Zn2+ binding site [ion binding]; other site
718274011815	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
718274011816	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
718274011817	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274011818	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274011819	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274011820	chloramphenicol acetyltransferase; Provisional; Region: PRK13757
718274011821	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
718274011822	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
718274011823	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
718274011824	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
718274011825	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
718274011826	multiple promoter invertase; Provisional; Region: mpi; PRK13413
718274011827	catalytic residues [active]
718274011828	catalytic nucleophile [active]
718274011829	Presynaptic Site I dimer interface [polypeptide binding]; other site
718274011830	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
718274011831	Synaptic Flat tetramer interface [polypeptide binding]; other site
718274011832	Synaptic Site I dimer interface [polypeptide binding]; other site
718274011833	DNA binding site [nucleotide binding]
718274011834	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
718274011835	DNA-binding interface [nucleotide binding]; DNA binding site
718274011836	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274011837	Domain of unknown function (DUF3330); Region: DUF3330; pfam11809
718274011838	integrase/recombinase; Provisional; Region: PRK15417
718274011839	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
718274011840	Int/Topo IB signature motif; other site
718274011841	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
718274011842	aminoglycoside resistance protein; Provisional; Region: PRK13746
718274011843	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
718274011844	active site
718274011845	NTP binding site [chemical binding]; other site
718274011846	metal binding triad [ion binding]; metal-binding site
718274011847	antibiotic binding site [chemical binding]; other site
718274011848	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
718274011849	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
718274011850	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
718274011851	dihydropteroate synthase; Region: DHPS; TIGR01496
718274011852	substrate binding pocket [chemical binding]; other site
718274011853	dimer interface [polypeptide binding]; other site
718274011854	inhibitor binding site; inhibition site
718274011855	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
718274011856	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274011857	Coenzyme A binding pocket [chemical binding]; other site
718274011858	transposase/IS protein; Provisional; Region: PRK09183
718274011859	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274011860	Walker A motif; other site
718274011861	ATP binding site [chemical binding]; other site
718274011862	Walker B motif; other site
718274011863	arginine finger; other site
718274011864	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
718274011865	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
718274011866	Integrase core domain; Region: rve; pfam00665
718274011867	Transposase; Region: HTH_Tnp_1; pfam01527
718274011868	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
718274011869	putative transposase OrfB; Reviewed; Region: PHA02517
718274011870	HTH-like domain; Region: HTH_21; pfam13276
718274011871	Integrase core domain; Region: rve; pfam00665
718274011872	Integrase core domain; Region: rve_2; pfam13333
718274011873	Bacterial TniB protein; Region: TniB; pfam05621
718274011874	Integrase core domain; Region: rve; pfam00665
718274011875	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
718274011876	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274011877	putative mercury resistance protein; Provisional; Region: PRK13747
718274011878	transcriptional regulator MerD; Provisional; Region: PRK13749
718274011879	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
718274011880	DNA binding residues [nucleotide binding]
718274011881	putative mercuric reductase; Provisional; Region: PRK13748
718274011882	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718274011883	metal-binding site [ion binding]
718274011884	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
718274011885	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274011886	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
718274011887	putative mercury transport protein MerC; Provisional; Region: PRK13755
718274011888	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
718274011889	metal-binding site [ion binding]
718274011890	putative mercuric transport protein; Provisional; Region: PRK13751
718274011891	putative transcriptional regulator MerR; Provisional; Region: PRK13752
718274011892	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
718274011893	DNA binding residues [nucleotide binding]
718274011894	dimer interface [polypeptide binding]; other site
718274011895	mercury binding site [ion binding]; other site
718274011896	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
718274011897	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274011898	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274011899	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274011900	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
718274011901	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274011902	DNA-binding site [nucleotide binding]; DNA binding site
718274011903	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
718274011904	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
718274011905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274011906	putative substrate translocation pore; other site
718274011907	regulatory protein UhpC; Provisional; Region: PRK11663
718274011908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274011909	putative substrate translocation pore; other site
718274011910	sensory histidine kinase UhpB; Provisional; Region: PRK11644
718274011911	MASE1; Region: MASE1; pfam05231
718274011912	Histidine kinase; Region: HisKA_3; pfam07730
718274011913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274011914	ATP binding site [chemical binding]; other site
718274011915	Mg2+ binding site [ion binding]; other site
718274011916	G-X-G motif; other site
718274011917	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
718274011918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274011919	active site
718274011920	phosphorylation site [posttranslational modification]
718274011921	intermolecular recognition site; other site
718274011922	dimerization interface [polypeptide binding]; other site
718274011923	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274011924	DNA binding residues [nucleotide binding]
718274011925	dimerization interface [polypeptide binding]; other site
718274011926	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
718274011927	active site
718274011928	catalytic residues [active]
718274011929	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
718274011930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274011931	putative substrate translocation pore; other site
718274011932	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718274011933	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
718274011934	substrate binding site [chemical binding]; other site
718274011935	dimer interface [polypeptide binding]; other site
718274011936	ATP binding site [chemical binding]; other site
718274011937	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
718274011938	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
718274011939	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274011940	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
718274011941	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
718274011942	putative valine binding site [chemical binding]; other site
718274011943	dimer interface [polypeptide binding]; other site
718274011944	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
718274011945	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
718274011946	PYR/PP interface [polypeptide binding]; other site
718274011947	dimer interface [polypeptide binding]; other site
718274011948	TPP binding site [chemical binding]; other site
718274011949	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
718274011950	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
718274011951	TPP-binding site [chemical binding]; other site
718274011952	dimer interface [polypeptide binding]; other site
718274011953	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
718274011954	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
718274011955	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
718274011956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274011957	putative substrate translocation pore; other site
718274011958	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
718274011959	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
718274011960	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274011961	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
718274011962	dimerization interface [polypeptide binding]; other site
718274011963	substrate binding pocket [chemical binding]; other site
718274011964	permease DsdX; Provisional; Region: PRK09921
718274011965	gluconate transporter; Region: gntP; TIGR00791
718274011966	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
718274011967	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
718274011968	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
718274011969	catalytic residue [active]
718274011970	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
718274011971	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
718274011972	Domain of unknown function (DUF202); Region: DUF202; pfam02656
718274011973	Predicted membrane protein [Function unknown]; Region: COG2149
718274011974	putative transporter; Validated; Region: PRK03818
718274011975	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
718274011976	TrkA-C domain; Region: TrkA_C; pfam02080
718274011977	TrkA-C domain; Region: TrkA_C; pfam02080
718274011978	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
718274011979	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
718274011980	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
718274011981	putative dimer interface [polypeptide binding]; other site
718274011982	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
718274011983	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
718274011984	putative dimer interface [polypeptide binding]; other site
718274011985	hypothetical protein; Provisional; Region: PRK11616
718274011986	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
718274011987	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
718274011988	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
718274011989	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
718274011990	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
718274011991	catalytic residues [active]
718274011992	central insert; other site
718274011993	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
718274011994	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
718274011995	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
718274011996	heme exporter protein CcmC; Region: ccmC; TIGR01191
718274011997	heme exporter protein CcmB; Region: ccmB; TIGR01190
718274011998	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
718274011999	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274012000	Walker A/P-loop; other site
718274012001	ATP binding site [chemical binding]; other site
718274012002	Q-loop/lid; other site
718274012003	ABC transporter signature motif; other site
718274012004	Walker B; other site
718274012005	D-loop; other site
718274012006	H-loop/switch region; other site
718274012007	Haem-binding domain; Region: Haem_bd; pfam14376
718274012008	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
718274012009	chaperone protein TorD; Validated; Region: torD; PRK04976
718274012010	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
718274012011	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
718274012012	molybdopterin cofactor binding site [chemical binding]; other site
718274012013	substrate binding site [chemical binding]; other site
718274012014	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
718274012015	molybdopterin cofactor binding site; other site
718274012016	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
718274012017	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
718274012018	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
718274012019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274012020	active site
718274012021	phosphorylation site [posttranslational modification]
718274012022	intermolecular recognition site; other site
718274012023	dimerization interface [polypeptide binding]; other site
718274012024	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274012025	DNA binding site [nucleotide binding]
718274012026	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
718274012027	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
718274012028	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
718274012029	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274012030	dimer interface [polypeptide binding]; other site
718274012031	phosphorylation site [posttranslational modification]
718274012032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274012033	ATP binding site [chemical binding]; other site
718274012034	Mg2+ binding site [ion binding]; other site
718274012035	G-X-G motif; other site
718274012036	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274012037	active site
718274012038	phosphorylation site [posttranslational modification]
718274012039	intermolecular recognition site; other site
718274012040	dimerization interface [polypeptide binding]; other site
718274012041	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
718274012042	putative binding surface; other site
718274012043	active site
718274012044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274012045	D-galactonate transporter; Region: 2A0114; TIGR00893
718274012046	putative substrate translocation pore; other site
718274012047	galactonate dehydratase; Provisional; Region: PRK14017
718274012048	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
718274012049	putative active site pocket [active]
718274012050	putative metal binding site [ion binding]; other site
718274012051	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
718274012052	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
718274012053	active site
718274012054	intersubunit interface [polypeptide binding]; other site
718274012055	catalytic residue [active]
718274012056	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
718274012057	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
718274012058	Transcriptional regulators [Transcription]; Region: FadR; COG2186
718274012059	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274012060	DNA-binding site [nucleotide binding]; DNA binding site
718274012061	FCD domain; Region: FCD; pfam07729
718274012062	sugar phosphate phosphatase; Provisional; Region: PRK10513
718274012063	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274012064	active site
718274012065	motif I; other site
718274012066	motif II; other site
718274012067	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274012068	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274012069	D-galactonate transporter; Region: 2A0114; TIGR00893
718274012070	putative substrate translocation pore; other site
718274012071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274012072	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
718274012073	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
718274012074	active site pocket [active]
718274012075	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274012076	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274012077	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
718274012078	putative dimerization interface [polypeptide binding]; other site
718274012079	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
718274012080	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274012081	Mg2+ binding site [ion binding]; other site
718274012082	G-X-G motif; other site
718274012083	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
718274012084	anchoring element; other site
718274012085	dimer interface [polypeptide binding]; other site
718274012086	ATP binding site [chemical binding]; other site
718274012087	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
718274012088	active site
718274012089	putative metal-binding site [ion binding]; other site
718274012090	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
718274012091	recF protein; Region: recf; TIGR00611
718274012092	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274012093	Walker A/P-loop; other site
718274012094	ATP binding site [chemical binding]; other site
718274012095	Q-loop/lid; other site
718274012096	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274012097	ABC transporter signature motif; other site
718274012098	Walker B; other site
718274012099	D-loop; other site
718274012100	H-loop/switch region; other site
718274012101	DNA polymerase III subunit beta; Validated; Region: PRK05643
718274012102	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
718274012103	putative DNA binding surface [nucleotide binding]; other site
718274012104	dimer interface [polypeptide binding]; other site
718274012105	beta-clamp/clamp loader binding surface; other site
718274012106	beta-clamp/translesion DNA polymerase binding surface; other site
718274012107	DnaA N-terminal domain; Region: DnaA_N; pfam11638
718274012108	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
718274012109	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274012110	Walker A motif; other site
718274012111	ATP binding site [chemical binding]; other site
718274012112	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
718274012113	Walker B motif; other site
718274012114	arginine finger; other site
718274012115	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
718274012116	DnaA box-binding interface [nucleotide binding]; other site
718274012117	ribonuclease P; Reviewed; Region: rnpA; PRK01732
718274012118	hypothetical protein; Validated; Region: PRK00041
718274012119	membrane protein insertase; Provisional; Region: PRK01318
718274012120	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
718274012121	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
718274012122	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
718274012123	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
718274012124	trmE is a tRNA modification GTPase; Region: trmE; cd04164
718274012125	G1 box; other site
718274012126	GTP/Mg2+ binding site [chemical binding]; other site
718274012127	Switch I region; other site
718274012128	G2 box; other site
718274012129	Switch II region; other site
718274012130	G3 box; other site
718274012131	G4 box; other site
718274012132	G5 box; other site
718274012133	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
718274012134	potential frameshift: common BLAST hit: gi|74318841|ref|YP_316581.1| phage integrase
718274012135	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
718274012136	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
718274012137	active site
718274012138	Int/Topo IB signature motif; other site
718274012139	putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331
718274012140	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
718274012141	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
718274012142	putative active site [active]
718274012143	putative NTP binding site [chemical binding]; other site
718274012144	putative nucleic acid binding site [nucleotide binding]; other site
718274012145	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
718274012146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274012147	putative substrate translocation pore; other site
718274012148	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
718274012149	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274012150	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
718274012151	substrate binding pocket [chemical binding]; other site
718274012152	dimerization interface [polypeptide binding]; other site
718274012153	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
718274012154	Predicted flavoprotein [General function prediction only]; Region: COG0431
718274012155	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
718274012156	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
718274012157	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
718274012158	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274012159	active site
718274012160	motif I; other site
718274012161	motif II; other site
718274012162	transcriptional regulator PhoU; Provisional; Region: PRK11115
718274012163	PhoU domain; Region: PhoU; pfam01895
718274012164	PhoU domain; Region: PhoU; pfam01895
718274012165	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
718274012166	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
718274012167	Walker A/P-loop; other site
718274012168	ATP binding site [chemical binding]; other site
718274012169	Q-loop/lid; other site
718274012170	ABC transporter signature motif; other site
718274012171	Walker B; other site
718274012172	D-loop; other site
718274012173	H-loop/switch region; other site
718274012174	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
718274012175	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274012176	dimer interface [polypeptide binding]; other site
718274012177	conserved gate region; other site
718274012178	putative PBP binding loops; other site
718274012179	ABC-ATPase subunit interface; other site
718274012180	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
718274012181	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274012182	dimer interface [polypeptide binding]; other site
718274012183	conserved gate region; other site
718274012184	putative PBP binding loops; other site
718274012185	ABC-ATPase subunit interface; other site
718274012186	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274012187	substrate binding pocket [chemical binding]; other site
718274012188	membrane-bound complex binding site; other site
718274012189	hinge residues; other site
718274012190	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
718274012191	active site
718274012192	P-loop; other site
718274012193	phosphorylation site [posttranslational modification]
718274012194	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
718274012195	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
718274012196	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
718274012197	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
718274012198	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
718274012199	shikimate binding site; other site
718274012200	NAD(P) binding site [chemical binding]; other site
718274012201	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
718274012202	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
718274012203	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
718274012204	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
718274012205	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
718274012206	glutaminase active site [active]
718274012207	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
718274012208	dimer interface [polypeptide binding]; other site
718274012209	active site
718274012210	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
718274012211	dimer interface [polypeptide binding]; other site
718274012212	active site
718274012213	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
718274012214	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
718274012215	Substrate binding site; other site
718274012216	Mg++ binding site; other site
718274012217	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
718274012218	active site
718274012219	substrate binding site [chemical binding]; other site
718274012220	CoA binding site [chemical binding]; other site
718274012221	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
718274012222	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
718274012223	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
718274012224	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
718274012225	gamma subunit interface [polypeptide binding]; other site
718274012226	epsilon subunit interface [polypeptide binding]; other site
718274012227	LBP interface [polypeptide binding]; other site
718274012228	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
718274012229	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
718274012230	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
718274012231	alpha subunit interaction interface [polypeptide binding]; other site
718274012232	Walker A motif; other site
718274012233	ATP binding site [chemical binding]; other site
718274012234	Walker B motif; other site
718274012235	inhibitor binding site; inhibition site
718274012236	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
718274012237	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
718274012238	core domain interface [polypeptide binding]; other site
718274012239	delta subunit interface [polypeptide binding]; other site
718274012240	epsilon subunit interface [polypeptide binding]; other site
718274012241	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
718274012242	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
718274012243	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
718274012244	beta subunit interaction interface [polypeptide binding]; other site
718274012245	Walker A motif; other site
718274012246	ATP binding site [chemical binding]; other site
718274012247	Walker B motif; other site
718274012248	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
718274012249	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
718274012250	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
718274012251	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
718274012252	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
718274012253	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
718274012254	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
718274012255	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
718274012256	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
718274012257	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
718274012258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274012259	S-adenosylmethionine binding site [chemical binding]; other site
718274012260	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
718274012261	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
718274012262	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
718274012263	FMN-binding protein MioC; Provisional; Region: PRK09004
718274012264	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
718274012265	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718274012266	putative DNA binding site [nucleotide binding]; other site
718274012267	putative Zn2+ binding site [ion binding]; other site
718274012268	AsnC family; Region: AsnC_trans_reg; pfam01037
718274012269	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
718274012270	dimer interface [polypeptide binding]; other site
718274012271	active site
718274012272	hypothetical protein; Provisional; Region: yieM; PRK10997
718274012273	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
718274012274	metal ion-dependent adhesion site (MIDAS); other site
718274012275	regulatory ATPase RavA; Provisional; Region: PRK13531
718274012276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274012277	Walker A motif; other site
718274012278	ATP binding site [chemical binding]; other site
718274012279	Walker B motif; other site
718274012280	arginine finger; other site
718274012281	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
718274012282	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
718274012283	potassium uptake protein; Region: kup; TIGR00794
718274012284	D-ribose pyranase; Provisional; Region: PRK11797
718274012285	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
718274012286	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
718274012287	Walker A/P-loop; other site
718274012288	ATP binding site [chemical binding]; other site
718274012289	Q-loop/lid; other site
718274012290	ABC transporter signature motif; other site
718274012291	Walker B; other site
718274012292	D-loop; other site
718274012293	H-loop/switch region; other site
718274012294	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
718274012295	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718274012296	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
718274012297	TM-ABC transporter signature motif; other site
718274012298	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
718274012299	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
718274012300	ligand binding site [chemical binding]; other site
718274012301	dimerization interface [polypeptide binding]; other site
718274012302	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718274012303	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
718274012304	substrate binding site [chemical binding]; other site
718274012305	dimer interface [polypeptide binding]; other site
718274012306	ATP binding site [chemical binding]; other site
718274012307	transcriptional repressor RbsR; Provisional; Region: PRK10423
718274012308	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274012309	DNA binding site [nucleotide binding]
718274012310	domain linker motif; other site
718274012311	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
718274012312	dimerization interface [polypeptide binding]; other site
718274012313	ligand binding site [chemical binding]; other site
718274012314	putative transporter; Provisional; Region: PRK10504
718274012315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274012316	putative substrate translocation pore; other site
718274012317	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274012318	Transcriptional regulators [Transcription]; Region: FadR; COG2186
718274012319	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274012320	DNA-binding site [nucleotide binding]; DNA binding site
718274012321	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
718274012322	transcriptional regulator HdfR; Provisional; Region: PRK03601
718274012323	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274012324	LysR substrate binding domain; Region: LysR_substrate; pfam03466
718274012325	dimerization interface [polypeptide binding]; other site
718274012326	hypothetical protein; Provisional; Region: PRK11027
718274012327	putative ATP-dependent protease; Provisional; Region: PRK09862
718274012328	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
718274012329	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274012330	Walker A motif; other site
718274012331	ATP binding site [chemical binding]; other site
718274012332	Walker B motif; other site
718274012333	arginine finger; other site
718274012334	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
718274012335	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
718274012336	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
718274012337	PYR/PP interface [polypeptide binding]; other site
718274012338	dimer interface [polypeptide binding]; other site
718274012339	TPP binding site [chemical binding]; other site
718274012340	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
718274012341	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
718274012342	TPP-binding site [chemical binding]; other site
718274012343	dimer interface [polypeptide binding]; other site
718274012344	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
718274012345	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
718274012346	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
718274012347	homodimer interface [polypeptide binding]; other site
718274012348	substrate-cofactor binding pocket; other site
718274012349	catalytic residue [active]
718274012350	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
718274012351	threonine dehydratase; Reviewed; Region: PRK09224
718274012352	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
718274012353	tetramer interface [polypeptide binding]; other site
718274012354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274012355	catalytic residue [active]
718274012356	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
718274012357	putative Ile/Val binding site [chemical binding]; other site
718274012358	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
718274012359	putative Ile/Val binding site [chemical binding]; other site
718274012360	Phage-related protein [Function unknown]; Region: COG4679
718274012361	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
718274012362	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274012363	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
718274012364	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
718274012365	putative dimerization interface [polypeptide binding]; other site
718274012366	ketol-acid reductoisomerase; Validated; Region: PRK05225
718274012367	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
718274012368	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
718274012369	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
718274012370	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
718274012371	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
718274012372	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
718274012373	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
718274012374	Part of AAA domain; Region: AAA_19; pfam13245
718274012375	Family description; Region: UvrD_C_2; pfam13538
718274012376	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
718274012377	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
718274012378	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
718274012379	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
718274012380	ATP binding site [chemical binding]; other site
718274012381	Mg++ binding site [ion binding]; other site
718274012382	motif III; other site
718274012383	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274012384	nucleotide binding region [chemical binding]; other site
718274012385	ATP-binding site [chemical binding]; other site
718274012386	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
718274012387	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
718274012388	catalytic residues [active]
718274012389	transcription termination factor Rho; Provisional; Region: rho; PRK09376
718274012390	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
718274012391	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
718274012392	RNA binding site [nucleotide binding]; other site
718274012393	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
718274012394	multimer interface [polypeptide binding]; other site
718274012395	Walker A motif; other site
718274012396	ATP binding site [chemical binding]; other site
718274012397	Walker B motif; other site
718274012398	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
718274012399	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
718274012400	Mg++ binding site [ion binding]; other site
718274012401	putative catalytic motif [active]
718274012402	substrate binding site [chemical binding]; other site
718274012403	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
718274012404	Chain length determinant protein; Region: Wzz; pfam02706
718274012405	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
718274012406	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
718274012407	homodimer interface [polypeptide binding]; other site
718274012408	active site
718274012409	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
718274012410	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
718274012411	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
718274012412	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
718274012413	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
718274012414	NAD binding site [chemical binding]; other site
718274012415	substrate binding site [chemical binding]; other site
718274012416	homodimer interface [polypeptide binding]; other site
718274012417	active site
718274012418	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
718274012419	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
718274012420	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
718274012421	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
718274012422	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
718274012423	inhibitor-cofactor binding pocket; inhibition site
718274012424	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274012425	catalytic residue [active]
718274012426	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
718274012427	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
718274012428	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
718274012429	putative common antigen polymerase; Provisional; Region: PRK02975
718274012430	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
718274012431	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
718274012432	putative transport protein YifK; Provisional; Region: PRK10746
718274012433	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
718274012434	HemY protein N-terminus; Region: HemY_N; pfam07219
718274012435	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
718274012436	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
718274012437	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
718274012438	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
718274012439	active site
718274012440	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
718274012441	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
718274012442	domain interfaces; other site
718274012443	active site
718274012444	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
718274012445	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
718274012446	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
718274012447	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
718274012448	putative iron binding site [ion binding]; other site
718274012449	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
718274012450	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
718274012451	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
718274012452	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
718274012453	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
718274012454	hypothetical protein; Provisional; Region: PRK10963
718274012455	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
718274012456	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
718274012457	active site
718274012458	Int/Topo IB signature motif; other site
718274012459	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
718274012460	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274012461	motif II; other site
718274012462	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
718274012463	Part of AAA domain; Region: AAA_19; pfam13245
718274012464	Family description; Region: UvrD_C_2; pfam13538
718274012465	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
718274012466	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
718274012467	Cl binding site [ion binding]; other site
718274012468	oligomer interface [polypeptide binding]; other site
718274012469	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
718274012470	hypothetical protein; Provisional; Region: PRK11371
718274012471	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
718274012472	EamA-like transporter family; Region: EamA; cl17759
718274012473	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
718274012474	CoenzymeA binding site [chemical binding]; other site
718274012475	subunit interaction site [polypeptide binding]; other site
718274012476	PHB binding site; other site
718274012477	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
718274012478	dimerization interface [polypeptide binding]; other site
718274012479	substrate binding site [chemical binding]; other site
718274012480	active site
718274012481	calcium binding site [ion binding]; other site
718274012482	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
718274012483	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718274012484	ATP binding site [chemical binding]; other site
718274012485	putative Mg++ binding site [ion binding]; other site
718274012486	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
718274012487	nucleotide binding region [chemical binding]; other site
718274012488	ATP-binding site [chemical binding]; other site
718274012489	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
718274012490	Helicase and RNase D C-terminal; Region: HRDC; smart00341
718274012491	threonine efflux system; Provisional; Region: PRK10229
718274012492	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
718274012493	lysophospholipase L2; Provisional; Region: PRK10749
718274012494	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
718274012495	putative hydrolase; Provisional; Region: PRK10976
718274012496	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274012497	active site
718274012498	motif I; other site
718274012499	motif II; other site
718274012500	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274012501	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
718274012502	EamA-like transporter family; Region: EamA; pfam00892
718274012503	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
718274012504	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274012505	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
718274012506	putative dimerization interface [polypeptide binding]; other site
718274012507	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
718274012508	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
718274012509	THF binding site; other site
718274012510	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
718274012511	substrate binding site [chemical binding]; other site
718274012512	THF binding site; other site
718274012513	zinc-binding site [ion binding]; other site
718274012514	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
718274012515	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274012516	FeS/SAM binding site; other site
718274012517	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
718274012518	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
718274012519	uridine phosphorylase; Provisional; Region: PRK11178
718274012520	uridine phosphorylase; Region: Uridine-psphlse; TIGR01718
718274012521	DNA recombination protein RmuC; Provisional; Region: PRK10361
718274012522	RmuC family; Region: RmuC; pfam02646
718274012523	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
718274012524	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274012525	S-adenosylmethionine binding site [chemical binding]; other site
718274012526	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
718274012527	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
718274012528	SCP-2 sterol transfer family; Region: SCP2; pfam02036
718274012529	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
718274012530	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
718274012531	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
718274012532	sec-independent translocase; Provisional; Region: PRK01770
718274012533	sec-independent translocase; Provisional; Region: tatB; PRK00404
718274012534	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
718274012535	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
718274012536	active site
718274012537	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
718274012538	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
718274012539	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
718274012540	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
718274012541	FMN reductase; Validated; Region: fre; PRK08051
718274012542	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
718274012543	FAD binding pocket [chemical binding]; other site
718274012544	FAD binding motif [chemical binding]; other site
718274012545	phosphate binding motif [ion binding]; other site
718274012546	beta-alpha-beta structure motif; other site
718274012547	NAD binding pocket [chemical binding]; other site
718274012548	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
718274012549	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
718274012550	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
718274012551	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
718274012552	dimer interface [polypeptide binding]; other site
718274012553	active site
718274012554	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
718274012555	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
718274012556	substrate binding site [chemical binding]; other site
718274012557	oxyanion hole (OAH) forming residues; other site
718274012558	trimer interface [polypeptide binding]; other site
718274012559	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
718274012560	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
718274012561	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
718274012562	proline dipeptidase; Provisional; Region: PRK13607
718274012563	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
718274012564	active site
718274012565	hypothetical protein; Provisional; Region: PRK11568
718274012566	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
718274012567	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
718274012568	potassium transporter; Provisional; Region: PRK10750
718274012569	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
718274012570	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
718274012571	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
718274012572	Walker A motif; other site
718274012573	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
718274012574	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
718274012575	GTP binding site; other site
718274012576	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
718274012577	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
718274012578	serine/threonine protein kinase; Provisional; Region: PRK11768
718274012579	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
718274012580	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
718274012581	catalytic residues [active]
718274012582	hinge region; other site
718274012583	alpha helical domain; other site
718274012584	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
718274012585	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
718274012586	putative acyl-acceptor binding pocket; other site
718274012587	DNA polymerase I; Provisional; Region: PRK05755
718274012588	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
718274012589	active site
718274012590	metal binding site 1 [ion binding]; metal-binding site
718274012591	putative 5' ssDNA interaction site; other site
718274012592	metal binding site 3; metal-binding site
718274012593	metal binding site 2 [ion binding]; metal-binding site
718274012594	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
718274012595	putative DNA binding site [nucleotide binding]; other site
718274012596	putative metal binding site [ion binding]; other site
718274012597	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
718274012598	active site
718274012599	catalytic site [active]
718274012600	substrate binding site [chemical binding]; other site
718274012601	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
718274012602	active site
718274012603	DNA binding site [nucleotide binding]
718274012604	catalytic site [active]
718274012605	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
718274012606	G1 box; other site
718274012607	GTP/Mg2+ binding site [chemical binding]; other site
718274012608	Switch I region; other site
718274012609	G2 box; other site
718274012610	G3 box; other site
718274012611	Switch II region; other site
718274012612	G4 box; other site
718274012613	G5 box; other site
718274012614	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
718274012615	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
718274012616	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274012617	FeS/SAM binding site; other site
718274012618	HemN C-terminal domain; Region: HemN_C; pfam06969
718274012619	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
718274012620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274012621	active site
718274012622	phosphorylation site [posttranslational modification]
718274012623	intermolecular recognition site; other site
718274012624	dimerization interface [polypeptide binding]; other site
718274012625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274012626	Walker A motif; other site
718274012627	ATP binding site [chemical binding]; other site
718274012628	Walker B motif; other site
718274012629	arginine finger; other site
718274012630	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
718274012631	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
718274012632	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
718274012633	putative active site [active]
718274012634	heme pocket [chemical binding]; other site
718274012635	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274012636	dimer interface [polypeptide binding]; other site
718274012637	phosphorylation site [posttranslational modification]
718274012638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274012639	ATP binding site [chemical binding]; other site
718274012640	Mg2+ binding site [ion binding]; other site
718274012641	G-X-G motif; other site
718274012642	glutamine synthetase; Provisional; Region: glnA; PRK09469
718274012643	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
718274012644	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
718274012645	GTP-binding protein; Provisional; Region: PRK10218
718274012646	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
718274012647	G1 box; other site
718274012648	putative GEF interaction site [polypeptide binding]; other site
718274012649	GTP/Mg2+ binding site [chemical binding]; other site
718274012650	Switch I region; other site
718274012651	G2 box; other site
718274012652	G3 box; other site
718274012653	Switch II region; other site
718274012654	G4 box; other site
718274012655	G5 box; other site
718274012656	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
718274012657	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
718274012658	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274012659	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
718274012660	active site
718274012661	motif I; other site
718274012662	motif II; other site
718274012663	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274012664	coproporphyrinogen III oxidase; Validated; Region: PRK08208
718274012665	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274012666	FeS/SAM binding site; other site
718274012667	HemN C-terminal domain; Region: HemN_C; pfam06969
718274012668	Sulfatase; Region: Sulfatase; cl17466
718274012669	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
718274012670	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
718274012671	Leucine-rich repeats; other site
718274012672	Substrate binding site [chemical binding]; other site
718274012673	outer membrane porin L; Provisional; Region: ompL; PRK09980
718274012674	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
718274012675	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274012676	putative substrate translocation pore; other site
718274012677	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
718274012678	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
718274012679	alpha-glucosidase; Provisional; Region: PRK10426
718274012680	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
718274012681	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
718274012682	putative active site [active]
718274012683	putative catalytic site [active]
718274012684	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
718274012685	active site
718274012686	catalytic residues [active]
718274012687	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
718274012688	dimerization interface [polypeptide binding]; other site
718274012689	putative active cleft [active]
718274012690	Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684
718274012691	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
718274012692	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
718274012693	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718274012694	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
718274012695	substrate binding site [chemical binding]; other site
718274012696	ATP binding site [chemical binding]; other site
718274012697	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
718274012698	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
718274012699	putative DNA binding site [nucleotide binding]; other site
718274012700	putative Zn2+ binding site [ion binding]; other site
718274012701	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274012702	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
718274012703	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274012704	motif II; other site
718274012705	hypothetical protein; Reviewed; Region: PRK01637
718274012706	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
718274012707	putative active site [active]
718274012708	dimerization interface [polypeptide binding]; other site
718274012709	putative tRNAtyr binding site [nucleotide binding]; other site
718274012710	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274012711	Coenzyme A binding pocket [chemical binding]; other site
718274012712	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
718274012713	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274012714	non-specific DNA binding site [nucleotide binding]; other site
718274012715	salt bridge; other site
718274012716	sequence-specific DNA binding site [nucleotide binding]; other site
718274012717	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
718274012718	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
718274012719	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
718274012720	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
718274012721	Predicted transcriptional regulator [Transcription]; Region: COG2944
718274012722	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274012723	non-specific DNA binding site [nucleotide binding]; other site
718274012724	salt bridge; other site
718274012725	sequence-specific DNA binding site [nucleotide binding]; other site
718274012726	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
718274012727	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
718274012728	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
718274012729	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
718274012730	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
718274012731	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
718274012732	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
718274012733	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
718274012734	[4Fe-4S] binding site [ion binding]; other site
718274012735	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
718274012736	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
718274012737	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
718274012738	molybdopterin cofactor binding site; other site
718274012739	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
718274012740	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
718274012741	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
718274012742	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
718274012743	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
718274012744	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274012745	non-specific DNA binding site [nucleotide binding]; other site
718274012746	salt bridge; other site
718274012747	sequence-specific DNA binding site [nucleotide binding]; other site
718274012748	Cupin domain; Region: Cupin_2; cl17218
718274012749	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
718274012750	lactaldehyde reductase; Region: lactal_redase; TIGR02638
718274012751	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
718274012752	dimer interface [polypeptide binding]; other site
718274012753	active site
718274012754	metal binding site [ion binding]; metal-binding site
718274012755	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
718274012756	intersubunit interface [polypeptide binding]; other site
718274012757	active site
718274012758	Zn2+ binding site [ion binding]; other site
718274012759	L-rhamnose isomerase; Provisional; Region: PRK01076
718274012760	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
718274012761	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
718274012762	N- and C-terminal domain interface [polypeptide binding]; other site
718274012763	active site
718274012764	putative catalytic site [active]
718274012765	metal binding site [ion binding]; metal-binding site
718274012766	ATP binding site [chemical binding]; other site
718274012767	rhamnulokinase; Provisional; Region: rhaB; PRK10640
718274012768	carbohydrate binding site [chemical binding]; other site
718274012769	transcriptional activator RhaS; Provisional; Region: PRK13503
718274012770	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718274012771	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274012772	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274012773	transcriptional activator RhaR; Provisional; Region: PRK13502
718274012774	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718274012775	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274012776	L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379
718274012777	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
718274012778	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
718274012779	DctM-like transporters; Region: DctM; pfam06808
718274012780	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
718274012781	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
718274012782	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
718274012783	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
718274012784	superoxide dismutase; Provisional; Region: PRK10925
718274012785	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
718274012786	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
718274012787	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
718274012788	MOSC domain; Region: MOSC; pfam03473
718274012789	3-alpha domain; Region: 3-alpha; pfam03475
718274012790	SnoaL-like domain; Region: SnoaL_2; pfam12680
718274012791	two-component sensor protein; Provisional; Region: cpxA; PRK09470
718274012792	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274012793	dimerization interface [polypeptide binding]; other site
718274012794	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274012795	dimer interface [polypeptide binding]; other site
718274012796	phosphorylation site [posttranslational modification]
718274012797	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274012798	ATP binding site [chemical binding]; other site
718274012799	Mg2+ binding site [ion binding]; other site
718274012800	G-X-G motif; other site
718274012801	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
718274012802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274012803	active site
718274012804	intermolecular recognition site; other site
718274012805	dimerization interface [polypeptide binding]; other site
718274012806	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274012807	DNA binding site [nucleotide binding]
718274012808	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
718274012809	dimer interface [polypeptide binding]; other site
718274012810	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
718274012811	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
718274012812	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
718274012813	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
718274012814	active site
718274012815	ADP/pyrophosphate binding site [chemical binding]; other site
718274012816	dimerization interface [polypeptide binding]; other site
718274012817	allosteric effector site; other site
718274012818	fructose-1,6-bisphosphate binding site; other site
718274012819	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
718274012820	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274012821	substrate binding pocket [chemical binding]; other site
718274012822	membrane-bound complex binding site; other site
718274012823	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
718274012824	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
718274012825	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
718274012826	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718274012827	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
718274012828	putative substrate binding site [chemical binding]; other site
718274012829	putative ATP binding site [chemical binding]; other site
718274012830	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
718274012831	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
718274012832	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274012833	DNA-binding site [nucleotide binding]; DNA binding site
718274012834	Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293
718274012835	UTRA domain; Region: UTRA; pfam07702
718274012836	CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934
718274012837	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
718274012838	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
718274012839	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
718274012840	putative N- and C-terminal domain interface [polypeptide binding]; other site
718274012841	putative active site [active]
718274012842	putative MgATP binding site [chemical binding]; other site
718274012843	catalytic site [active]
718274012844	metal binding site [ion binding]; metal-binding site
718274012845	putative carbohydrate binding site [chemical binding]; other site
718274012846	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
718274012847	transcriptional regulator LsrR; Provisional; Region: PRK15418
718274012848	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
718274012849	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
718274012850	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
718274012851	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
718274012852	Walker A/P-loop; other site
718274012853	ATP binding site [chemical binding]; other site
718274012854	Q-loop/lid; other site
718274012855	ABC transporter signature motif; other site
718274012856	Walker B; other site
718274012857	D-loop; other site
718274012858	H-loop/switch region; other site
718274012859	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
718274012860	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718274012861	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
718274012862	TM-ABC transporter signature motif; other site
718274012863	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
718274012864	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
718274012865	TM-ABC transporter signature motif; other site
718274012866	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
718274012867	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
718274012868	ligand binding site [chemical binding]; other site
718274012869	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
718274012870	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
718274012871	putative active site; other site
718274012872	catalytic residue [active]
718274012873	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
718274012874	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
718274012875	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
718274012876	substrate binding site [chemical binding]; other site
718274012877	hexamer interface [polypeptide binding]; other site
718274012878	metal binding site [ion binding]; metal-binding site
718274012879	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
718274012880	triosephosphate isomerase; Provisional; Region: PRK14567
718274012881	substrate binding site [chemical binding]; other site
718274012882	dimer interface [polypeptide binding]; other site
718274012883	catalytic triad [active]
718274012884	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
718274012885	Predicted membrane protein [Function unknown]; Region: COG3152
718274012886	ferredoxin-NADP reductase; Provisional; Region: PRK10926
718274012887	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
718274012888	FAD binding pocket [chemical binding]; other site
718274012889	FAD binding motif [chemical binding]; other site
718274012890	phosphate binding motif [ion binding]; other site
718274012891	beta-alpha-beta structure motif; other site
718274012892	NAD binding pocket [chemical binding]; other site
718274012893	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
718274012894	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
718274012895	putative active site [active]
718274012896	glycerol kinase; Provisional; Region: glpK; PRK00047
718274012897	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
718274012898	N- and C-terminal domain interface [polypeptide binding]; other site
718274012899	active site
718274012900	MgATP binding site [chemical binding]; other site
718274012901	catalytic site [active]
718274012902	metal binding site [ion binding]; metal-binding site
718274012903	glycerol binding site [chemical binding]; other site
718274012904	homotetramer interface [polypeptide binding]; other site
718274012905	homodimer interface [polypeptide binding]; other site
718274012906	FBP binding site [chemical binding]; other site
718274012907	protein IIAGlc interface [polypeptide binding]; other site
718274012908	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
718274012909	amphipathic channel; other site
718274012910	Asn-Pro-Ala signature motifs; other site
718274012911	septal ring assembly protein ZapB; Provisional; Region: PRK15422
718274012912	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
718274012913	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
718274012914	UbiA prenyltransferase family; Region: UbiA; pfam01040
718274012915	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
718274012916	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274012917	Walker A motif; other site
718274012918	ATP binding site [chemical binding]; other site
718274012919	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
718274012920	Walker B motif; other site
718274012921	arginine finger; other site
718274012922	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
718274012923	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
718274012924	active site
718274012925	HslU subunit interaction site [polypeptide binding]; other site
718274012926	essential cell division protein FtsN; Provisional; Region: PRK10927
718274012927	cell division protein FtsN; Provisional; Region: PRK12757
718274012928	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274012929	DNA binding site [nucleotide binding]
718274012930	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
718274012931	domain linker motif; other site
718274012932	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
718274012933	dimerization interface [polypeptide binding]; other site
718274012934	ligand binding site [chemical binding]; other site
718274012935	primosome assembly protein PriA; Validated; Region: PRK05580
718274012936	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718274012937	ATP binding site [chemical binding]; other site
718274012938	putative Mg++ binding site [ion binding]; other site
718274012939	helicase superfamily c-terminal domain; Region: HELICc; smart00490
718274012940	ATP-binding site [chemical binding]; other site
718274012941	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
718274012942	conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117
718274012943	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
718274012944	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
718274012945	dimerization interface [polypeptide binding]; other site
718274012946	DNA binding site [nucleotide binding]
718274012947	corepressor binding sites; other site
718274012948	cystathionine gamma-synthase; Provisional; Region: PRK08045
718274012949	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
718274012950	homodimer interface [polypeptide binding]; other site
718274012951	substrate-cofactor binding pocket; other site
718274012952	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274012953	catalytic residue [active]
718274012954	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
718274012955	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
718274012956	putative catalytic residues [active]
718274012957	putative nucleotide binding site [chemical binding]; other site
718274012958	putative aspartate binding site [chemical binding]; other site
718274012959	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
718274012960	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
718274012961	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
718274012962	mechanosensitive channel MscS; Provisional; Region: PRK10334
718274012963	Conserved TM helix; Region: TM_helix; pfam05552
718274012964	Mechanosensitive ion channel; Region: MS_channel; pfam00924
718274012965	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
718274012966	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
718274012967	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
718274012968	active site
718274012969	metal binding site [ion binding]; metal-binding site
718274012970	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
718274012971	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
718274012972	FAD binding site [chemical binding]; other site
718274012973	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
718274012974	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
718274012975	heme binding site [chemical binding]; other site
718274012976	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
718274012977	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738
718274012978	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
718274012979	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
718274012980	dimer interface [polypeptide binding]; other site
718274012981	active site
718274012982	metal binding site [ion binding]; metal-binding site
718274012983	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
718274012984	active site
718274012985	intersubunit interactions; other site
718274012986	catalytic residue [active]
718274012987	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
718274012988	dimerization domain swap beta strand [polypeptide binding]; other site
718274012989	regulatory protein interface [polypeptide binding]; other site
718274012990	active site
718274012991	regulatory phosphorylation site [posttranslational modification]; other site
718274012992	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
718274012993	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
718274012994	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
718274012995	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
718274012996	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718274012997	active site
718274012998	phosphorylation site [posttranslational modification]
718274012999	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
718274013000	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
718274013001	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
718274013002	active site
718274013003	P-loop; other site
718274013004	phosphorylation site [posttranslational modification]
718274013005	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
718274013006	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
718274013007	dimer interface [polypeptide binding]; other site
718274013008	active site
718274013009	glycine loop; other site
718274013010	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274013011	FeS/SAM binding site; other site
718274013012	pyruvate formate lyase II activase; Provisional; Region: PRK10076
718274013013	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
718274013014	active site
718274013015	P-loop; other site
718274013016	phosphorylation site [posttranslational modification]
718274013017	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718274013018	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274013019	hypothetical protein; Provisional; Region: PRK10649
718274013020	Sulfatase; Region: Sulfatase; pfam00884
718274013021	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
718274013022	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
718274013023	acetylornithine deacetylase; Provisional; Region: PRK05111
718274013024	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
718274013025	metal binding site [ion binding]; metal-binding site
718274013026	putative dimer interface [polypeptide binding]; other site
718274013027	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
718274013028	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
718274013029	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
718274013030	nucleotide binding site [chemical binding]; other site
718274013031	N-acetyl-L-glutamate binding site [chemical binding]; other site
718274013032	argininosuccinate lyase; Provisional; Region: PRK04833
718274013033	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
718274013034	active sites [active]
718274013035	tetramer interface [polypeptide binding]; other site
718274013036	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
718274013037	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274013038	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
718274013039	dimerization interface [polypeptide binding]; other site
718274013040	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
718274013041	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
718274013042	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
718274013043	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
718274013044	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274013045	hypothetical protein; Provisional; Region: PRK11056
718274013046	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
718274013047	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
718274013048	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274013049	S-adenosylmethionine binding site [chemical binding]; other site
718274013050	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
718274013051	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
718274013052	N-terminal plug; other site
718274013053	ligand-binding site [chemical binding]; other site
718274013054	glutamate racemase; Provisional; Region: PRK00865
718274013055	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
718274013056	FAD binding domain; Region: FAD_binding_4; pfam01565
718274013057	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
718274013058	Biotin operon repressor [Transcription]; Region: BirA; COG1654
718274013059	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
718274013060	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
718274013061	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
718274013062	pantothenate kinase; Provisional; Region: PRK05439
718274013063	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
718274013064	ATP-binding site [chemical binding]; other site
718274013065	CoA-binding site [chemical binding]; other site
718274013066	Mg2+-binding site [ion binding]; other site
718274013067	elongation factor Tu; Reviewed; Region: PRK00049
718274013068	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
718274013069	G1 box; other site
718274013070	GEF interaction site [polypeptide binding]; other site
718274013071	GTP/Mg2+ binding site [chemical binding]; other site
718274013072	Switch I region; other site
718274013073	G2 box; other site
718274013074	G3 box; other site
718274013075	Switch II region; other site
718274013076	G4 box; other site
718274013077	G5 box; other site
718274013078	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
718274013079	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
718274013080	Antibiotic Binding Site [chemical binding]; other site
718274013081	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
718274013082	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
718274013083	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
718274013084	putative homodimer interface [polypeptide binding]; other site
718274013085	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
718274013086	heterodimer interface [polypeptide binding]; other site
718274013087	homodimer interface [polypeptide binding]; other site
718274013088	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
718274013089	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
718274013090	23S rRNA interface [nucleotide binding]; other site
718274013091	L7/L12 interface [polypeptide binding]; other site
718274013092	putative thiostrepton binding site; other site
718274013093	L25 interface [polypeptide binding]; other site
718274013094	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
718274013095	mRNA/rRNA interface [nucleotide binding]; other site
718274013096	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
718274013097	23S rRNA interface [nucleotide binding]; other site
718274013098	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
718274013099	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
718274013100	core dimer interface [polypeptide binding]; other site
718274013101	peripheral dimer interface [polypeptide binding]; other site
718274013102	L10 interface [polypeptide binding]; other site
718274013103	L11 interface [polypeptide binding]; other site
718274013104	putative EF-Tu interaction site [polypeptide binding]; other site
718274013105	putative EF-G interaction site [polypeptide binding]; other site
718274013106	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
718274013107	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
718274013108	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
718274013109	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
718274013110	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
718274013111	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
718274013112	RPB3 interaction site [polypeptide binding]; other site
718274013113	RPB1 interaction site [polypeptide binding]; other site
718274013114	RPB11 interaction site [polypeptide binding]; other site
718274013115	RPB10 interaction site [polypeptide binding]; other site
718274013116	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
718274013117	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
718274013118	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
718274013119	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
718274013120	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
718274013121	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
718274013122	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
718274013123	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
718274013124	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
718274013125	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
718274013126	DNA binding site [nucleotide binding]
718274013127	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
718274013128	type III secretion system protein; Provisional; Region: PRK15384
718274013129	non-LEE encoded effector protein NleB; Provisional; Region: PRK15382
718274013130	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
718274013131	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274013132	FeS/SAM binding site; other site
718274013133	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
718274013134	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
718274013135	ThiS interaction site; other site
718274013136	putative active site [active]
718274013137	tetramer interface [polypeptide binding]; other site
718274013138	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
718274013139	thiS-thiF/thiG interaction site; other site
718274013140	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
718274013141	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
718274013142	ATP binding site [chemical binding]; other site
718274013143	substrate interface [chemical binding]; other site
718274013144	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
718274013145	thiamine phosphate binding site [chemical binding]; other site
718274013146	active site
718274013147	pyrophosphate binding site [ion binding]; other site
718274013148	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
718274013149	ThiC-associated domain; Region: ThiC-associated; pfam13667
718274013150	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
718274013151	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
718274013152	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
718274013153	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
718274013154	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
718274013155	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
718274013156	putative NADH binding site [chemical binding]; other site
718274013157	putative active site [active]
718274013158	nudix motif; other site
718274013159	putative metal binding site [ion binding]; other site
718274013160	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
718274013161	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
718274013162	substrate binding site [chemical binding]; other site
718274013163	active site
718274013164	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
718274013165	Active_site [active]
718274013166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
718274013167	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
718274013168	IHF dimer interface [polypeptide binding]; other site
718274013169	IHF - DNA interface [nucleotide binding]; other site
718274013170	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
718274013171	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
718274013172	dimer interface [polypeptide binding]; other site
718274013173	sensor protein ZraS; Provisional; Region: PRK10364
718274013174	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274013175	dimer interface [polypeptide binding]; other site
718274013176	phosphorylation site [posttranslational modification]
718274013177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274013178	ATP binding site [chemical binding]; other site
718274013179	Mg2+ binding site [ion binding]; other site
718274013180	G-X-G motif; other site
718274013181	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
718274013182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274013183	active site
718274013184	phosphorylation site [posttranslational modification]
718274013185	intermolecular recognition site; other site
718274013186	dimerization interface [polypeptide binding]; other site
718274013187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274013188	Walker A motif; other site
718274013189	ATP binding site [chemical binding]; other site
718274013190	Walker B motif; other site
718274013191	arginine finger; other site
718274013192	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
718274013193	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
718274013194	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
718274013195	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
718274013196	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
718274013197	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
718274013198	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
718274013199	purine monophosphate binding site [chemical binding]; other site
718274013200	dimer interface [polypeptide binding]; other site
718274013201	putative catalytic residues [active]
718274013202	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
718274013203	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
718274013204	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274013205	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
718274013206	Coenzyme A binding pocket [chemical binding]; other site
718274013207	homoserine O-succinyltransferase; Provisional; Region: PRK05368
718274013208	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
718274013209	proposed active site lysine [active]
718274013210	conserved cys residue [active]
718274013211	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
718274013212	malate synthase A; Region: malate_syn_A; TIGR01344
718274013213	active site
718274013214	isocitrate lyase; Provisional; Region: PRK15063
718274013215	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
718274013216	tetramer interface [polypeptide binding]; other site
718274013217	active site
718274013218	Mg2+/Mn2+ binding site [ion binding]; other site
718274013219	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
718274013220	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
718274013221	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
718274013222	transcriptional repressor IclR; Provisional; Region: PRK11569
718274013223	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
718274013224	Bacterial transcriptional regulator; Region: IclR; pfam01614
718274013225	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
718274013226	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
718274013227	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
718274013228	substrate binding pocket [chemical binding]; other site
718274013229	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
718274013230	B12 binding site [chemical binding]; other site
718274013231	cobalt ligand [ion binding]; other site
718274013232	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
718274013233	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
718274013234	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
718274013235	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
718274013236	active site pocket [active]
718274013237	oxyanion hole [active]
718274013238	catalytic triad [active]
718274013239	active site nucleophile [active]
718274013240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
718274013241	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
718274013242	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
718274013243	RNA binding surface [nucleotide binding]; other site
718274013244	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
718274013245	probable active site [active]
718274013246	hypothetical protein; Provisional; Region: PRK10515
718274013247	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
718274013248	Sodium Bile acid symporter family; Region: SBF; pfam01758
718274013249	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
718274013250	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
718274013251	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
718274013252	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
718274013253	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
718274013254	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
718274013255	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
718274013256	Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948
718274013257	Phage baseplate assembly protein W [General function prediction only]; Region: COG3628
718274013258	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
718274013259	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
718274013260	Ligand binding site; other site
718274013261	Putative Catalytic site; other site
718274013262	DXD motif; other site
718274013263	Predicted membrane protein [Function unknown]; Region: COG2246
718274013264	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
718274013265	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
718274013266	Phage protein D [General function prediction only]; Region: COG3500
718274013267	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
718274013268	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
718274013269	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
718274013270	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
718274013271	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
718274013272	Phage tail tube protein FII [General function prediction only]; Region: COG3498
718274013273	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
718274013274	Gp37 protein; Region: Gp37; pfam09646
718274013275	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
718274013276	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718274013277	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718274013278	catalytic residue [active]
718274013279	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
718274013280	Mor transcription activator family; Region: Mor; pfam08765
718274013281	aspartate kinase III; Validated; Region: PRK09084
718274013282	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
718274013283	nucleotide binding site [chemical binding]; other site
718274013284	substrate binding site [chemical binding]; other site
718274013285	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
718274013286	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
718274013287	dimer interface [polypeptide binding]; other site
718274013288	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
718274013289	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
718274013290	active site
718274013291	dimer interface [polypeptide binding]; other site
718274013292	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
718274013293	dimer interface [polypeptide binding]; other site
718274013294	active site
718274013295	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
718274013296	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
718274013297	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
718274013298	Predicted membrane protein [Function unknown]; Region: COG3223
718274013299	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
718274013300	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274013301	dimer interface [polypeptide binding]; other site
718274013302	conserved gate region; other site
718274013303	putative PBP binding loops; other site
718274013304	ABC-ATPase subunit interface; other site
718274013305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
718274013306	dimer interface [polypeptide binding]; other site
718274013307	conserved gate region; other site
718274013308	putative PBP binding loops; other site
718274013309	ABC-ATPase subunit interface; other site
718274013310	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
718274013311	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
718274013312	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
718274013313	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
718274013314	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
718274013315	Walker A/P-loop; other site
718274013316	ATP binding site [chemical binding]; other site
718274013317	Q-loop/lid; other site
718274013318	ABC transporter signature motif; other site
718274013319	Walker B; other site
718274013320	D-loop; other site
718274013321	H-loop/switch region; other site
718274013322	TOBE domain; Region: TOBE_2; pfam08402
718274013323	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
718274013324	trimer interface; other site
718274013325	sugar binding site [chemical binding]; other site
718274013326	maltose regulon periplasmic protein; Provisional; Region: PRK10564
718274013327	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
718274013328	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
718274013329	UbiA prenyltransferase family; Region: UbiA; pfam01040
718274013330	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
718274013331	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
718274013332	putative acyl-acceptor binding pocket; other site
718274013333	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
718274013334	LexA repressor; Validated; Region: PRK00215
718274013335	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
718274013336	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
718274013337	Catalytic site [active]
718274013338	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
718274013339	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
718274013340	hypothetical protein; Provisional; Region: PRK10428
718274013341	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
718274013342	metal binding site 2 [ion binding]; metal-binding site
718274013343	putative DNA binding helix; other site
718274013344	metal binding site 1 [ion binding]; metal-binding site
718274013345	dimer interface [polypeptide binding]; other site
718274013346	structural Zn2+ binding site [ion binding]; other site
718274013347	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
718274013348	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
718274013349	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
718274013350	FMN binding site [chemical binding]; other site
718274013351	active site
718274013352	catalytic residues [active]
718274013353	substrate binding site [chemical binding]; other site
718274013354	phage shock protein G; Reviewed; Region: pspG; PRK09459
718274013355	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
718274013356	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
718274013357	NADP binding site [chemical binding]; other site
718274013358	dimer interface [polypeptide binding]; other site
718274013359	replicative DNA helicase; Provisional; Region: PRK08006
718274013360	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
718274013361	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
718274013362	Walker A motif; other site
718274013363	ATP binding site [chemical binding]; other site
718274013364	Walker B motif; other site
718274013365	DNA binding loops [nucleotide binding]
718274013366	alanine racemase; Reviewed; Region: alr; PRK00053
718274013367	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
718274013368	active site
718274013369	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
718274013370	substrate binding site [chemical binding]; other site
718274013371	catalytic residues [active]
718274013372	dimer interface [polypeptide binding]; other site
718274013373	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
718274013374	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
718274013375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
718274013376	homodimer interface [polypeptide binding]; other site
718274013377	catalytic residue [active]
718274013378	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
718274013379	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274013380	active site
718274013381	motif I; other site
718274013382	motif II; other site
718274013383	Uncharacterized conserved protein [Function unknown]; Region: COG0432
718274013384	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
718274013385	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
718274013386	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
718274013387	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
718274013388	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
718274013389	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
718274013390	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
718274013391	dimer interface [polypeptide binding]; other site
718274013392	ssDNA binding site [nucleotide binding]; other site
718274013393	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718274013394	hypothetical protein; Validated; Region: PRK09039
718274013395	Zinc finger-containing protein; Region: zf-C4H2; pfam10146
718274013396	Outer membrane efflux protein; Region: OEP; pfam02321
718274013397	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
718274013398	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
718274013399	HlyD family secretion protein; Region: HlyD_3; pfam13437
718274013400	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
718274013401	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013402	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013403	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013404	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013405	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013406	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
718274013407	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
718274013408	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013409	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
718274013410	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
718274013411	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013412	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
718274013413	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013414	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
718274013415	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
718274013416	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013417	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
718274013418	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013419	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
718274013420	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
718274013421	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013422	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
718274013423	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
718274013424	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013425	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
718274013426	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013427	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013428	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
718274013429	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013430	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013431	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013432	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013433	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013434	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
718274013435	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013436	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
718274013437	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013438	Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245
718274013439	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013440	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
718274013441	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
718274013442	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274013443	Walker A/P-loop; other site
718274013444	ATP binding site [chemical binding]; other site
718274013445	Q-loop/lid; other site
718274013446	ABC transporter signature motif; other site
718274013447	Walker B; other site
718274013448	D-loop; other site
718274013449	H-loop/switch region; other site
718274013450	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
718274013451	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
718274013452	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274013453	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
718274013454	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274013455	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
718274013456	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
718274013457	DNA binding residues [nucleotide binding]
718274013458	dimer interface [polypeptide binding]; other site
718274013459	[2Fe-2S] cluster binding site [ion binding]; other site
718274013460	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
718274013461	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
718274013462	putative C-terminal domain interface [polypeptide binding]; other site
718274013463	putative GSH binding site (G-site) [chemical binding]; other site
718274013464	putative dimer interface [polypeptide binding]; other site
718274013465	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
718274013466	putative N-terminal domain interface [polypeptide binding]; other site
718274013467	putative dimer interface [polypeptide binding]; other site
718274013468	putative substrate binding pocket (H-site) [chemical binding]; other site
718274013469	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
718274013470	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
718274013471	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
718274013472	Transcriptional regulator [Transcription]; Region: LysR; COG0583
718274013473	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274013474	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
718274013475	putative dimerization interface [polypeptide binding]; other site
718274013476	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
718274013477	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
718274013478	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
718274013479	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
718274013480	Na binding site [ion binding]; other site
718274013481	Predicted membrane protein [Function unknown]; Region: COG3162
718274013482	acetyl-CoA synthetase; Provisional; Region: PRK00174
718274013483	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
718274013484	active site
718274013485	CoA binding site [chemical binding]; other site
718274013486	acyl-activating enzyme (AAE) consensus motif; other site
718274013487	AMP binding site [chemical binding]; other site
718274013488	acetate binding site [chemical binding]; other site
718274013489	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
718274013490	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
718274013491	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
718274013492	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
718274013493	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
718274013494	heme lyase subunit NrfE; Provisional; Region: PRK10369
718274013495	formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144
718274013496	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
718274013497	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
718274013498	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
718274013499	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
718274013500	Sel1-like repeats; Region: SEL1; smart00671
718274013501	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
718274013502	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
718274013503	[4Fe-4S] binding site [ion binding]; other site
718274013504	molybdopterin cofactor binding site; other site
718274013505	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
718274013506	molybdopterin cofactor binding site; other site
718274013507	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
718274013508	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274013509	Coenzyme A binding pocket [chemical binding]; other site
718274013510	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
718274013511	dimer interface [polypeptide binding]; other site
718274013512	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
718274013513	hypothetical protein; Provisional; Region: PRK10220
718274013514	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
718274013515	PhnA protein; Region: PhnA; pfam03831
718274013516	proline/glycine betaine transporter; Provisional; Region: PRK10642
718274013517	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274013518	putative substrate translocation pore; other site
718274013519	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
718274013520	sensor protein BasS/PmrB; Provisional; Region: PRK10755
718274013521	HAMP domain; Region: HAMP; pfam00672
718274013522	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274013523	dimer interface [polypeptide binding]; other site
718274013524	phosphorylation site [posttranslational modification]
718274013525	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274013526	ATP binding site [chemical binding]; other site
718274013527	Mg2+ binding site [ion binding]; other site
718274013528	G-X-G motif; other site
718274013529	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
718274013530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274013531	active site
718274013532	phosphorylation site [posttranslational modification]
718274013533	intermolecular recognition site; other site
718274013534	dimerization interface [polypeptide binding]; other site
718274013535	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274013536	DNA binding site [nucleotide binding]
718274013537	putative metal dependent hydrolase; Provisional; Region: PRK11598
718274013538	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
718274013539	Sulfatase; Region: Sulfatase; pfam00884
718274013540	arginine:agmatin antiporter; Provisional; Region: PRK10644
718274013541	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
718274013542	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
718274013543	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
718274013544	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
718274013545	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
718274013546	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
718274013547	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
718274013548	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
718274013549	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274013550	active site
718274013551	phosphorylation site [posttranslational modification]
718274013552	intermolecular recognition site; other site
718274013553	dimerization interface [polypeptide binding]; other site
718274013554	sensory histidine kinase DcuS; Provisional; Region: PRK11086
718274013555	PAS domain; Region: PAS; smart00091
718274013556	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274013557	ATP binding site [chemical binding]; other site
718274013558	Mg2+ binding site [ion binding]; other site
718274013559	G-X-G motif; other site
718274013560	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
718274013561	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
718274013562	putative [Fe4-S4] binding site [ion binding]; other site
718274013563	putative molybdopterin cofactor binding site [chemical binding]; other site
718274013564	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
718274013565	putative molybdopterin cofactor binding site; other site
718274013566	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
718274013567	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
718274013568	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
718274013569	Domain of unknown function (DUF1996); Region: DUF1996; pfam09362
718274013570	SdiA-regulated; Region: SdiA-regulated; pfam06977
718274013571	SdiA-regulated; Region: SdiA-regulated; cd09971
718274013572	putative active site [active]
718274013573	Transposase IS200 like; Region: Y1_Tnp; pfam01797
718274013574	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
718274013575	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274013576	DNA binding residues [nucleotide binding]
718274013577	dimerization interface [polypeptide binding]; other site
718274013578	AraC family transcriptional regulator; Provisional; Region: PRK15186
718274013579	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274013580	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
718274013581	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274013582	Coenzyme A binding pocket [chemical binding]; other site
718274013583	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
718274013584	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
718274013585	active site
718274013586	EthD domain; Region: EthD; pfam07110
718274013587	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
718274013588	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
718274013589	DNA binding residues [nucleotide binding]
718274013590	putative dimer interface [polypeptide binding]; other site
718274013591	putative transcriptional regulator; Provisional; Region: PRK11640
718274013592	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
718274013593	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
718274013594	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
718274013595	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
718274013596	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
718274013597	DsbD alpha interface [polypeptide binding]; other site
718274013598	catalytic residues [active]
718274013599	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
718274013600	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
718274013601	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
718274013602	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
718274013603	Aspartase; Region: Aspartase; cd01357
718274013604	active sites [active]
718274013605	tetramer interface [polypeptide binding]; other site
718274013606	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
718274013607	putative transporter; Provisional; Region: PRK11021
718274013608	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
718274013609	oligomerisation interface [polypeptide binding]; other site
718274013610	mobile loop; other site
718274013611	roof hairpin; other site
718274013612	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
718274013613	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
718274013614	ring oligomerisation interface [polypeptide binding]; other site
718274013615	ATP/Mg binding site [chemical binding]; other site
718274013616	stacking interactions; other site
718274013617	hinge regions; other site
718274013618	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
718274013619	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
718274013620	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274013621	FeS/SAM binding site; other site
718274013622	elongation factor P; Validated; Region: PRK00529
718274013623	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
718274013624	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
718274013625	RNA binding site [nucleotide binding]; other site
718274013626	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
718274013627	RNA binding site [nucleotide binding]; other site
718274013628	Predicted small secreted protein [Function unknown]; Region: COG5510
718274013629	entericidin B membrane lipoprotein; Provisional; Region: PRK10081
718274013630	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
718274013631	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274013632	DNA binding residues [nucleotide binding]
718274013633	dimerization interface [polypeptide binding]; other site
718274013634	multidrug efflux system protein; Provisional; Region: PRK11431
718274013635	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
718274013636	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
718274013637	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
718274013638	Iron-sulfur protein interface; other site
718274013639	proximal quinone binding site [chemical binding]; other site
718274013640	C-subunit interface; other site
718274013641	distal quinone binding site; other site
718274013642	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
718274013643	D-subunit interface [polypeptide binding]; other site
718274013644	Iron-sulfur protein interface; other site
718274013645	proximal quinone binding site [chemical binding]; other site
718274013646	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
718274013647	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
718274013648	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
718274013649	L-aspartate oxidase; Provisional; Region: PRK06175
718274013650	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
718274013651	poxB regulator PoxA; Provisional; Region: PRK09350
718274013652	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
718274013653	motif 1; other site
718274013654	dimer interface [polypeptide binding]; other site
718274013655	active site
718274013656	motif 2; other site
718274013657	motif 3; other site
718274013658	inner membrane transporter YjeM; Provisional; Region: PRK15238
718274013659	Protein of unknown function (DUF2645); Region: DUF2645; pfam10840
718274013660	putative mechanosensitive channel protein; Provisional; Region: PRK10929
718274013661	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
718274013662	Mechanosensitive ion channel; Region: MS_channel; pfam00924
718274013663	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
718274013664	GTPase RsgA; Reviewed; Region: PRK12288
718274013665	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
718274013666	RNA binding site [nucleotide binding]; other site
718274013667	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
718274013668	GTPase/Zn-binding domain interface [polypeptide binding]; other site
718274013669	GTP/Mg2+ binding site [chemical binding]; other site
718274013670	G4 box; other site
718274013671	G5 box; other site
718274013672	G1 box; other site
718274013673	Switch I region; other site
718274013674	G2 box; other site
718274013675	G3 box; other site
718274013676	Switch II region; other site
718274013677	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
718274013678	catalytic site [active]
718274013679	putative active site [active]
718274013680	putative substrate binding site [chemical binding]; other site
718274013681	dimer interface [polypeptide binding]; other site
718274013682	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
718274013683	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
718274013684	substrate binding pocket [chemical binding]; other site
718274013685	membrane-bound complex binding site; other site
718274013686	hinge residues; other site
718274013687	epoxyqueuosine reductase; Region: TIGR00276
718274013688	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
718274013689	putative carbohydrate kinase; Provisional; Region: PRK10565
718274013690	Uncharacterized conserved protein [Function unknown]; Region: COG0062
718274013691	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
718274013692	putative substrate binding site [chemical binding]; other site
718274013693	putative ATP binding site [chemical binding]; other site
718274013694	ADP-binding protein; Provisional; Region: PRK10646
718274013695	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
718274013696	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
718274013697	active site
718274013698	metal binding site [ion binding]; metal-binding site
718274013699	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
718274013700	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274013701	ATP binding site [chemical binding]; other site
718274013702	Mg2+ binding site [ion binding]; other site
718274013703	G-X-G motif; other site
718274013704	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
718274013705	ATP binding site [chemical binding]; other site
718274013706	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
718274013707	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
718274013708	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
718274013709	bacterial Hfq-like; Region: Hfq; cd01716
718274013710	hexamer interface [polypeptide binding]; other site
718274013711	Sm1 motif; other site
718274013712	RNA binding site [nucleotide binding]; other site
718274013713	Sm2 motif; other site
718274013714	GTPase HflX; Provisional; Region: PRK11058
718274013715	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
718274013716	HflX GTPase family; Region: HflX; cd01878
718274013717	G1 box; other site
718274013718	GTP/Mg2+ binding site [chemical binding]; other site
718274013719	Switch I region; other site
718274013720	G2 box; other site
718274013721	G3 box; other site
718274013722	Switch II region; other site
718274013723	G4 box; other site
718274013724	G5 box; other site
718274013725	FtsH protease regulator HflK; Provisional; Region: PRK10930
718274013726	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
718274013727	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
718274013728	FtsH protease regulator HflC; Provisional; Region: PRK11029
718274013729	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
718274013730	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
718274013731	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
718274013732	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
718274013733	GDP-binding site [chemical binding]; other site
718274013734	ACT binding site; other site
718274013735	IMP binding site; other site
718274013736	transcriptional repressor NsrR; Provisional; Region: PRK11014
718274013737	Predicted transcriptional regulator [Transcription]; Region: COG1959
718274013738	exoribonuclease R; Provisional; Region: PRK11642
718274013739	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
718274013740	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
718274013741	RNB domain; Region: RNB; pfam00773
718274013742	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
718274013743	RNA binding site [nucleotide binding]; other site
718274013744	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
718274013745	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
718274013746	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
718274013747	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789
718274013748	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
718274013749	Ion channel; Region: Ion_trans_2; pfam07885
718274013750	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
718274013751	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
718274013752	Predicted membrane protein [Function unknown]; Region: COG3766
718274013753	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
718274013754	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
718274013755	Predicted integral membrane protein [Function unknown]; Region: COG5463
718274013756	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
718274013757	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
718274013758	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
718274013759	FAD binding site [chemical binding]; other site
718274013760	substrate binding site [chemical binding]; other site
718274013761	catalytic residues [active]
718274013762	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
718274013763	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
718274013764	esterase; Provisional; Region: PRK10566
718274013765	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
718274013766	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
718274013767	transcriptional repressor UlaR; Provisional; Region: PRK13509
718274013768	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
718274013769	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
718274013770	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
718274013771	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
718274013772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
718274013773	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
718274013774	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
718274013775	active site
718274013776	P-loop; other site
718274013777	phosphorylation site [posttranslational modification]
718274013778	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718274013779	active site
718274013780	phosphorylation site [posttranslational modification]
718274013781	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
718274013782	active site
718274013783	dimer interface [polypeptide binding]; other site
718274013784	magnesium binding site [ion binding]; other site
718274013785	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
718274013786	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
718274013787	AP (apurinic/apyrimidinic) site pocket; other site
718274013788	DNA interaction; other site
718274013789	Metal-binding active site; metal-binding site
718274013790	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
718274013791	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
718274013792	intersubunit interface [polypeptide binding]; other site
718274013793	active site
718274013794	Zn2+ binding site [ion binding]; other site
718274013795	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
718274013796	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
718274013797	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
718274013798	dimer interface [polypeptide binding]; other site
718274013799	ssDNA binding site [nucleotide binding]; other site
718274013800	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718274013801	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
718274013802	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
718274013803	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
718274013804	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
718274013805	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
718274013806	EamA-like transporter family; Region: EamA; pfam00892
718274013807	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
718274013808	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
718274013809	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
718274013810	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
718274013811	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
718274013812	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
718274013813	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
718274013814	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
718274013815	Hemerythrin-like domain; Region: Hr-like; cd12108
718274013816	Fe binding site [ion binding]; other site
718274013817	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
718274013818	EamA-like transporter family; Region: EamA; pfam00892
718274013819	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
718274013820	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
718274013821	NADP binding site [chemical binding]; other site
718274013822	Predicted transcriptional regulators [Transcription]; Region: COG1733
718274013823	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
718274013824	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
718274013825	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
718274013826	active site
718274013827	metal binding site [ion binding]; metal-binding site
718274013828	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
718274013829	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
718274013830	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
718274013831	active site
718274013832	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
718274013833	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
718274013834	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
718274013835	Domain of unknown function DUF21; Region: DUF21; pfam01595
718274013836	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
718274013837	Transporter associated domain; Region: CorC_HlyC; smart01091
718274013838	methionine sulfoxide reductase A; Provisional; Region: PRK00058
718274013839	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
718274013840	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
718274013841	Surface antigen; Region: Bac_surface_Ag; pfam01103
718274013842	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
718274013843	Family of unknown function (DUF490); Region: DUF490; pfam04357
718274013844	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
718274013845	putative active site pocket [active]
718274013846	dimerization interface [polypeptide binding]; other site
718274013847	putative catalytic residue [active]
718274013848	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274013849	D-galactonate transporter; Region: 2A0114; TIGR00893
718274013850	putative substrate translocation pore; other site
718274013851	putative metallo-dependent hydrolase; Provisional; Region: PRK12394
718274013852	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
718274013853	active site
718274013854	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
718274013855	dimer interface [polypeptide binding]; other site
718274013856	substrate binding site [chemical binding]; other site
718274013857	metal binding sites [ion binding]; metal-binding site
718274013858	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
718274013859	AMP binding site [chemical binding]; other site
718274013860	metal binding site [ion binding]; metal-binding site
718274013861	active site
718274013862	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
718274013863	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
718274013864	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
718274013865	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
718274013866	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
718274013867	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
718274013868	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
718274013869	putative active site [active]
718274013870	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
718274013871	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274013872	putative substrate translocation pore; other site
718274013873	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274013874	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
718274013875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274013876	putative substrate translocation pore; other site
718274013877	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274013878	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
718274013879	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
718274013880	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
718274013881	tetrameric interface [polypeptide binding]; other site
718274013882	NAD binding site [chemical binding]; other site
718274013883	catalytic residues [active]
718274013884	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
718274013885	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718274013886	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274013887	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
718274013888	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
718274013889	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
718274013890	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
718274013891	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
718274013892	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
718274013893	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
718274013894	major facilitator superfamily transporter; Provisional; Region: PRK05122
718274013895	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274013896	putative substrate translocation pore; other site
718274013897	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
718274013898	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
718274013899	substrate binding site [chemical binding]; other site
718274013900	ATP binding site [chemical binding]; other site
718274013901	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
718274013902	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
718274013903	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
718274013904	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
718274013905	PYR/PP interface [polypeptide binding]; other site
718274013906	dimer interface [polypeptide binding]; other site
718274013907	TPP binding site [chemical binding]; other site
718274013908	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
718274013909	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
718274013910	TPP-binding site; other site
718274013911	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
718274013912	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
718274013913	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
718274013914	polyol permease family; Region: 2A0118; TIGR00897
718274013915	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274013916	putative substrate translocation pore; other site
718274013917	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
718274013918	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
718274013919	DNA interaction; other site
718274013920	Metal-binding active site; metal-binding site
718274013921	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
718274013922	hypothetical protein; Provisional; Region: PRK05255
718274013923	peptidase PmbA; Provisional; Region: PRK11040
718274013924	cytochrome b562; Provisional; Region: PRK15058
718274013925	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
718274013926	conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577
718274013927	conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578
718274013928	conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580
718274013929	conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579
718274013930	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
718274013931	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
718274013932	active site
718274013933	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
718274013934	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
718274013935	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
718274013936	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
718274013937	HTH domain; Region: HTH_11; pfam08279
718274013938	Mga helix-turn-helix domain; Region: Mga; pfam05043
718274013939	PRD domain; Region: PRD; pfam00874
718274013940	PRD domain; Region: PRD; pfam00874
718274013941	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
718274013942	active site
718274013943	P-loop; other site
718274013944	phosphorylation site [posttranslational modification]
718274013945	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
718274013946	active site
718274013947	phosphorylation site [posttranslational modification]
718274013948	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
718274013949	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
718274013950	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
718274013951	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274013952	FeS/SAM binding site; other site
718274013953	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
718274013954	ATP cone domain; Region: ATP-cone; pfam03477
718274013955	Class III ribonucleotide reductase; Region: RNR_III; cd01675
718274013956	effector binding site; other site
718274013957	active site
718274013958	Zn binding site [ion binding]; other site
718274013959	glycine loop; other site
718274013960	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
718274013961	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
718274013962	Ca binding site [ion binding]; other site
718274013963	active site
718274013964	catalytic site [active]
718274013965	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
718274013966	potential frameshift: common BLAST hit: gi|198246006|ref|YP_002218318.1| PTS system trehalose(maltose)-specific transporter subunits IIBC
718274013967	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885
718274013968	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
718274013969	active site turn [active]
718274013970	phosphorylation site [posttranslational modification]
718274013971	PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826
718274013972	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
718274013973	trehalose repressor; Provisional; Region: treR; PRK09492
718274013974	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274013975	DNA binding site [nucleotide binding]
718274013976	domain linker motif; other site
718274013977	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
718274013978	dimerization interface [polypeptide binding]; other site
718274013979	ligand binding site [chemical binding]; other site
718274013980	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
718274013981	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
718274013982	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
718274013983	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
718274013984	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
718274013985	Soluble P-type ATPase [General function prediction only]; Region: COG4087
718274013986	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
718274013987	Transposase; Region: HTH_Tnp_1; cl17663
718274013988	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
718274013989	homotrimer interaction site [polypeptide binding]; other site
718274013990	putative active site [active]
718274013991	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
718274013992	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
718274013993	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
718274013994	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
718274013995	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
718274013996	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
718274013997	pyrBI operon leader peptide; Provisional; Region: PRK10224
718274013998	Arginine repressor [Transcription]; Region: ArgR; COG1438
718274013999	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
718274014000	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
718274014001	Predicted membrane protein [Function unknown]; Region: COG1288
718274014002	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
718274014003	ornithine carbamoyltransferase; Validated; Region: PRK02102
718274014004	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
718274014005	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
718274014006	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
718274014007	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
718274014008	putative substrate binding site [chemical binding]; other site
718274014009	nucleotide binding site [chemical binding]; other site
718274014010	nucleotide binding site [chemical binding]; other site
718274014011	homodimer interface [polypeptide binding]; other site
718274014012	arginine deiminase; Provisional; Region: PRK01388
718274014013	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
718274014014	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
718274014015	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
718274014016	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
718274014017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
718274014018	RNase E inhibitor protein; Provisional; Region: PRK11191
718274014019	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
718274014020	active site
718274014021	dinuclear metal binding site [ion binding]; other site
718274014022	dimerization interface [polypeptide binding]; other site
718274014023	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
718274014024	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
718274014025	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274014026	Coenzyme A binding pocket [chemical binding]; other site
718274014027	Predicted membrane protein [Function unknown]; Region: COG4269
718274014028	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
718274014029	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
718274014030	HIGH motif; other site
718274014031	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
718274014032	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
718274014033	active site
718274014034	KMSKS motif; other site
718274014035	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
718274014036	tRNA binding surface [nucleotide binding]; other site
718274014037	anticodon binding site; other site
718274014038	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
718274014039	DNA polymerase III subunit chi; Validated; Region: PRK05728
718274014040	multifunctional aminopeptidase A; Provisional; Region: PRK00913
718274014041	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
718274014042	interface (dimer of trimers) [polypeptide binding]; other site
718274014043	Substrate-binding/catalytic site; other site
718274014044	Zn-binding sites [ion binding]; other site
718274014045	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
718274014046	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
718274014047	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
718274014048	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
718274014049	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
718274014050	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
718274014051	DNA binding site [nucleotide binding]
718274014052	domain linker motif; other site
718274014053	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
718274014054	putative dimerization interface [polypeptide binding]; other site
718274014055	putative ligand binding site [chemical binding]; other site
718274014056	gluconate transporter; Region: gntP; TIGR00791
718274014057	fructuronate transporter; Provisional; Region: PRK10034; cl15264
718274014058	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
718274014059	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
718274014060	NADP binding site [chemical binding]; other site
718274014061	homodimer interface [polypeptide binding]; other site
718274014062	active site
718274014063	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
718274014064	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
718274014065	putative NAD(P) binding site [chemical binding]; other site
718274014066	catalytic Zn binding site [ion binding]; other site
718274014067	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
718274014068	ATP-binding site [chemical binding]; other site
718274014069	Gluconate-6-phosphate binding site [chemical binding]; other site
718274014070	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
718274014071	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
718274014072	putative NAD(P) binding site [chemical binding]; other site
718274014073	putative substrate binding site [chemical binding]; other site
718274014074	catalytic Zn binding site [ion binding]; other site
718274014075	structural Zn binding site [ion binding]; other site
718274014076	dimer interface [polypeptide binding]; other site
718274014077	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
718274014078	Part of AAA domain; Region: AAA_19; pfam13245
718274014079	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
718274014080	AAA domain; Region: AAA_12; pfam13087
718274014081	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
718274014082	putative active site [active]
718274014083	catalytic site [active]
718274014084	Uncharacterized conserved protein [Function unknown]; Region: COG4127
718274014085	Restriction endonuclease; Region: Mrr_cat; pfam04471
718274014086	conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653
718274014087	Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337
718274014088	TIGR02687 family protein; Region: TIGR02687
718274014089	PglZ domain; Region: PglZ; pfam08665
718274014090	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274014091	AAA domain; Region: AAA_21; pfam13304
718274014092	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274014093	Walker A/P-loop; other site
718274014094	Walker A/P-loop; other site
718274014095	ATP binding site [chemical binding]; other site
718274014096	ATP binding site [chemical binding]; other site
718274014097	Q-loop/lid; other site
718274014098	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
718274014099	Methyltransferase domain; Region: Methyltransf_26; pfam13659
718274014100	TIGR02680 family protein; Region: TIGR02680
718274014101	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
718274014102	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
718274014103	hypothetical protein; Provisional; Region: PRK12378
718274014104	Methyltransferase domain; Region: Methyltransf_23; pfam13489
718274014105	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274014106	S-adenosylmethionine binding site [chemical binding]; other site
718274014107	Methyltransferase domain; Region: Methyltransf_31; pfam13847
718274014108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274014109	S-adenosylmethionine binding site [chemical binding]; other site
718274014110	hypothetical protein; Provisional; Region: PRK13687
718274014111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332
718274014112	Protein of unknown function DUF91; Region: DUF91; cl00709
718274014113	Uncharacterized conserved protein [Function unknown]; Region: COG3439
718274014114	Dienelactone hydrolase family; Region: DLH; pfam01738
718274014115	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
718274014116	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
718274014117	DNA-binding site [nucleotide binding]; DNA binding site
718274014118	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
718274014119	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
718274014120	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
718274014121	active site
718274014122	HIGH motif; other site
718274014123	dimer interface [polypeptide binding]; other site
718274014124	KMSKS motif; other site
718274014125	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
718274014126	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
718274014127	aspartate racemase; Region: asp_race; TIGR00035
718274014128	cell density-dependent motility repressor; Provisional; Region: PRK10082
718274014129	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274014130	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718274014131	dimerization interface [polypeptide binding]; other site
718274014132	isoaspartyl dipeptidase; Provisional; Region: PRK10657
718274014133	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
718274014134	active site
718274014135	hypothetical protein; Provisional; Region: PRK10519
718274014136	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
718274014137	Nucleoside recognition; Region: Gate; pfam07670
718274014138	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
718274014139	Predicted membrane protein [Function unknown]; Region: COG2733
718274014140	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
718274014141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
718274014142	putative substrate translocation pore; other site
718274014143	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
718274014144	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
718274014145	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
718274014146	NAD(P) binding site [chemical binding]; other site
718274014147	catalytic residues [active]
718274014148	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
718274014149	endoribonuclease SymE; Provisional; Region: PRK13605
718274014150	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
718274014151	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
718274014152	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
718274014153	HsdM N-terminal domain; Region: HsdM_N; pfam12161
718274014154	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
718274014155	Methyltransferase domain; Region: Methyltransf_26; pfam13659
718274014156	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
718274014157	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
718274014158	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
718274014159	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
718274014160	ATP binding site [chemical binding]; other site
718274014161	putative Mg++ binding site [ion binding]; other site
718274014162	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
718274014163	Mrr N-terminal domain; Region: Mrr_N; pfam14338
718274014164	Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030
718274014165	Restriction endonuclease; Region: Mrr_cat; pfam04471
718274014166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
718274014167	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
718274014168	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
718274014169	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
718274014170	P-loop, Walker A motif; other site
718274014171	Base recognition motif; other site
718274014172	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
718274014173	Uncharacterized small protein [Function unknown]; Region: COG2879
718274014174	carbon starvation protein A; Provisional; Region: PRK15015
718274014175	Carbon starvation protein CstA; Region: CstA; pfam02554
718274014176	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
718274014177	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
718274014178	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
718274014179	dimer interface [polypeptide binding]; other site
718274014180	ligand binding site [chemical binding]; other site
718274014181	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
718274014182	dimerization interface [polypeptide binding]; other site
718274014183	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
718274014184	dimer interface [polypeptide binding]; other site
718274014185	putative CheW interface [polypeptide binding]; other site
718274014186	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
718274014187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274014188	Walker A motif; other site
718274014189	ATP binding site [chemical binding]; other site
718274014190	Walker B motif; other site
718274014191	arginine finger; other site
718274014192	Transcriptional antiterminator [Transcription]; Region: COG3933
718274014193	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
718274014194	active pocket/dimerization site; other site
718274014195	active site
718274014196	phosphorylation site [posttranslational modification]
718274014197	PRD domain; Region: PRD; pfam00874
718274014198	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
718274014199	active pocket/dimerization site; other site
718274014200	active site
718274014201	phosphorylation site [posttranslational modification]
718274014202	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
718274014203	active site
718274014204	phosphorylation site [posttranslational modification]
718274014205	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
718274014206	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
718274014207	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
718274014208	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
718274014209	dimer interface [polypeptide binding]; other site
718274014210	active site
718274014211	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
718274014212	dimer interface [polypeptide binding]; other site
718274014213	active site
718274014214	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
718274014215	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
718274014216	putative active site [active]
718274014217	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
718274014218	phosphoglycerol transferase I; Provisional; Region: PRK03776
718274014219	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
718274014220	hypothetical protein; Provisional; Region: PRK11667
718274014221	DNA replication protein DnaC; Validated; Region: PRK07952
718274014222	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
718274014223	Walker A motif; other site
718274014224	ATP binding site [chemical binding]; other site
718274014225	Walker B motif; other site
718274014226	primosomal protein DnaI; Provisional; Region: PRK02854
718274014227	hypothetical protein; Provisional; Region: PRK09917
718274014228	Uncharacterized conserved protein [Function unknown]; Region: COG2966
718274014229	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
718274014230	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
718274014231	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274014232	DNA binding residues [nucleotide binding]
718274014233	dimerization interface [polypeptide binding]; other site
718274014234	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
718274014235	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274014236	DNA binding residues [nucleotide binding]
718274014237	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
718274014238	putative deacylase active site [active]
718274014239	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
718274014240	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
718274014241	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
718274014242	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
718274014243	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
718274014244	metal binding site [ion binding]; metal-binding site
718274014245	active site
718274014246	I-site; other site
718274014247	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
718274014248	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
718274014249	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
718274014250	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
718274014251	S-adenosylmethionine binding site [chemical binding]; other site
718274014252	DNA polymerase III subunit psi; Validated; Region: PRK06856
718274014253	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
718274014254	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
718274014255	Coenzyme A binding pocket [chemical binding]; other site
718274014256	dUMP phosphatase; Provisional; Region: PRK09449
718274014257	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274014258	motif II; other site
718274014259	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
718274014260	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
718274014261	G1 box; other site
718274014262	putative GEF interaction site [polypeptide binding]; other site
718274014263	GTP/Mg2+ binding site [chemical binding]; other site
718274014264	Switch I region; other site
718274014265	G2 box; other site
718274014266	G3 box; other site
718274014267	Switch II region; other site
718274014268	G4 box; other site
718274014269	G5 box; other site
718274014270	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
718274014271	periplasmic protein; Provisional; Region: PRK10568
718274014272	BON domain; Region: BON; pfam04972
718274014273	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
718274014274	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
718274014275	active site
718274014276	nucleophile elbow; other site
718274014277	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
718274014278	active site
718274014279	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
718274014280	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
718274014281	FeS/SAM binding site; other site
718274014282	hypothetical protein; Provisional; Region: PRK10977
718274014283	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
718274014284	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
718274014285	intersubunit interface [polypeptide binding]; other site
718274014286	active site
718274014287	catalytic residue [active]
718274014288	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
718274014289	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
718274014290	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
718274014291	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
718274014292	phosphopentomutase; Provisional; Region: PRK05362
718274014293	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
718274014294	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
718274014295	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
718274014296	hypothetical protein; Provisional; Region: PRK15301
718274014297	putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304
718274014298	PapC N-terminal domain; Region: PapC_N; pfam13954
718274014299	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
718274014300	PapC C-terminal domain; Region: PapC_C; pfam13953
718274014301	putative fimbrial chaperone protein; Provisional; Region: PRK09918
718274014302	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274014303	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274014304	hypothetical protein; Provisional; Region: PRK15302
718274014305	hypothetical protein; Provisional; Region: PRK15303
718274014306	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
718274014307	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
718274014308	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
718274014309	hypothetical protein; Provisional; Region: PRK11246
718274014310	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
718274014311	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
718274014312	motif II; other site
718274014313	DNA repair protein RadA; Region: sms; TIGR00416
718274014314	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
718274014315	Walker A motif/ATP binding site; other site
718274014316	ATP binding site [chemical binding]; other site
718274014317	Walker B motif; other site
718274014318	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
718274014319	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
718274014320	non-specific DNA binding site [nucleotide binding]; other site
718274014321	salt bridge; other site
718274014322	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
718274014323	sequence-specific DNA binding site [nucleotide binding]; other site
718274014324	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
718274014325	active site
718274014326	(T/H)XGH motif; other site
718274014327	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
718274014328	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
718274014329	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718274014330	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718274014331	ABC transporter; Region: ABC_tran_2; pfam12848
718274014332	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
718274014333	lytic murein transglycosylase; Provisional; Region: PRK11619
718274014334	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718274014335	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718274014336	catalytic residue [active]
718274014337	Trp operon repressor; Provisional; Region: PRK01381
718274014338	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
718274014339	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
718274014340	catalytic core [active]
718274014341	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
718274014342	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274014343	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
718274014344	hypothetical protein; Provisional; Region: PRK10756
718274014345	CreA protein; Region: CreA; pfam05981
718274014346	DNA-binding response regulator CreB; Provisional; Region: PRK11083
718274014347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274014348	active site
718274014349	phosphorylation site [posttranslational modification]
718274014350	intermolecular recognition site; other site
718274014351	dimerization interface [polypeptide binding]; other site
718274014352	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274014353	DNA binding site [nucleotide binding]
718274014354	sensory histidine kinase CreC; Provisional; Region: PRK11100
718274014355	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
718274014356	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
718274014357	dimer interface [polypeptide binding]; other site
718274014358	phosphorylation site [posttranslational modification]
718274014359	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
718274014360	ATP binding site [chemical binding]; other site
718274014361	Mg2+ binding site [ion binding]; other site
718274014362	G-X-G motif; other site
718274014363	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
718274014364	putative major fimbrial protein SthE; Provisional; Region: PRK15292
718274014365	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
718274014366	putative fimbrial protein SthD; Provisional; Region: PRK15293
718274014367	putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294
718274014368	PapC N-terminal domain; Region: PapC_N; pfam13954
718274014369	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
718274014370	PapC C-terminal domain; Region: PapC_C; pfam13953
718274014371	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
718274014372	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274014373	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274014374	putative fimbrial protein SthA; Provisional; Region: PRK15296
718274014375	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
718274014376	Helix-turn-helix domain; Region: HTH_36; pfam13730
718274014377	two-component response regulator; Provisional; Region: PRK11173
718274014378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
718274014379	active site
718274014380	phosphorylation site [posttranslational modification]
718274014381	intermolecular recognition site; other site
718274014382	dimerization interface [polypeptide binding]; other site
718274014383	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
718274014384	DNA binding site [nucleotide binding]
718274014385	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
718274014386	putative RNA methyltransferase; Provisional; Region: PRK10433
718274014387	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
718274014388	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
718274014389	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
718274014390	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
718274014391	putative active site [active]
718274014392	catalytic site [active]
718274014393	replication protein; Provisional; Region: PRK13702
718274014394	replication protein; Provisional; Region: PRK13750
718274014395	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
718274014396	SdiA-regulated; Region: SdiA-regulated; cd09971
718274014397	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
718274014398	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
718274014399	resistance to complement killing; Provisional; Region: PRK15240
718274014400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
718274014401	SdiA-regulated; Region: SdiA-regulated; cd09971
718274014402	putative active site [active]
718274014403	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
718274014404	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
718274014405	catalytic residues [active]
718274014406	hinge region; other site
718274014407	alpha helical domain; other site
718274014408	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
718274014409	DNA binding residues [nucleotide binding]
718274014410	dimerization interface [polypeptide binding]; other site
718274014411	FaeA-like protein; Region: FaeA; pfam04703
718274014412	fimbrial chaperone protein PefD; Provisional; Region: PRK15211
718274014413	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
718274014414	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
718274014415	fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213
718274014416	PapC N-terminal domain; Region: PapC_N; pfam13954
718274014417	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
718274014418	fimbrial protein PefA; Provisional; Region: PRK15214
718274014419	Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333
718274014420	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
718274014421	plasmid maintenance protein CcdA; Provisional; Region: PRK13710
718274014422	plasmid maintenance protein CcdB; Provisional; Region: PRK13708
718274014423	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
718274014424	active site
718274014425	catalytic residues [active]
718274014426	DNA binding site [nucleotide binding]
718274014427	Int/Topo IB signature motif; other site
718274014428	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
718274014429	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
718274014430	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
718274014431	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
718274014432	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
718274014433	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
718274014434	Transposase IS200 like; Region: Y1_Tnp; pfam01797
718274014435	virulence protein SpvD; Provisional; Region: PRK15250
718274014436	Salmonella virulence-associated 28kDa protein; Region: VRP3; pfam03536
718274014437	virulence protein SpvB; Provisional; Region: PRK15244
718274014438	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
718274014439	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
718274014440	active site
718274014441	conformational flexibility of ligand binding pocket; other site
718274014442	ADP-ribosylating toxin turn-turn motif; other site
718274014443	virulence protein SpvA; Provisional; Region: PRK15212
718274014444	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
718274014445	transcriptional regulator SpvR; Provisional; Region: PRK15243
718274014446	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
718274014447	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
718274014448	Homeodomain-like domain; Region: HTH_23; pfam13384
718274014449	Winged helix-turn helix; Region: HTH_29; pfam13551
718274014450	Homeodomain-like domain; Region: HTH_32; pfam13565
718274014451	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
718274014452	DDE superfamily endonuclease; Region: DDE_3; pfam13358
718274014453	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
718274014454	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
718274014455	Walker A/P-loop; other site
718274014456	Integrase core domain; Region: rve; pfam00665
718274014457	Resolvase, N terminal domain; Region: Resolvase; pfam00239
718274014458	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718274014459	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
718274014460	DNA-binding interface [nucleotide binding]; DNA binding site
718274014461	Salmonella T000240 resistance island
718274014462	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
718274014463	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
718274014464	Integrase core domain; Region: rve; pfam00665
718274014465	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
718274014466	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
718274014467	AAA domain; Region: AAA_18; pfam13238
718274014468	active site
718274014469	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
718274014470	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
718274014471	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
718274014472	Integrase core domain; Region: rve; pfam00665
718274014473	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
718274014474	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
718274014475	Chromate transporter; Region: Chromate_transp; pfam02417
718274014476	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
718274014477	dihydropteroate synthase; Region: DHPS; TIGR01496
718274014478	substrate binding pocket [chemical binding]; other site
718274014479	dimer interface [polypeptide binding]; other site
718274014480	inhibitor binding site; inhibition site
718274014481	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
718274014482	aminoglycoside resistance protein; Provisional; Region: PRK13746
718274014483	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
718274014484	active site
718274014485	NTP binding site [chemical binding]; other site
718274014486	metal binding triad [ion binding]; metal-binding site
718274014487	antibiotic binding site [chemical binding]; other site
718274014488	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
718274014489	Protein of unknown function (DUF1010); Region: DUF1010; pfam06231
718274014490	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
718274014491	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
718274014492	folate binding site [chemical binding]; other site
718274014493	NADP+ binding site [chemical binding]; other site
718274014494	integrase/recombinase; Provisional; Region: PRK15417
718274014495	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
718274014496	Int/Topo IB signature motif; other site
718274014497	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
718274014498	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
718274014499	Integrase core domain; Region: rve; pfam00665
718274014500	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
718274014501	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
718274014502	catalytic residues [active]
718274014503	catalytic nucleophile [active]
718274014504	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
718274014505	active site clefts [active]
718274014506	zinc binding site [ion binding]; other site
718274014507	dimer interface [polypeptide binding]; other site
718274014508	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
718274014509	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
718274014510	catalytic site [active]
718274014511	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
718274014512	Uncharacterized conserved protein [Function unknown]; Region: COG5464
718274014513	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
718274014514	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
718274014515	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718274014516	P-loop; other site
718274014517	Magnesium ion binding site [ion binding]; other site
718274014518	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
718274014519	Magnesium ion binding site [ion binding]; other site
718274014520	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
718274014521	ParB-like nuclease domain; Region: ParBc; pfam02195
718274014522	ParB family; Region: ParB; pfam08775
718274014523	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
718274014524	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
718274014525	active site
718274014526	DNA binding site [nucleotide binding]
718274014527	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
718274014528	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
718274014529	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
718274014530	Catalytic site [active]
718274014531	putative methylase; Provisional; Region: PRK13699
718274014532	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
718274014533	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
718274014534	Antirestriction protein; Region: Antirestrict; pfam03230
718274014535	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
718274014536	DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440
718274014537	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
718274014538	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
718274014539	dimer interface [polypeptide binding]; other site
718274014540	ssDNA binding site [nucleotide binding]; other site
718274014541	tetramer (dimer of dimers) interface [polypeptide binding]; other site
718274014542	Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006
718274014543	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
718274014544	ParB-like nuclease domain; Region: ParBc; pfam02195
718274014545	Plasmid SOS inhibition protein (PsiB); Region: PsiB; pfam06290
718274014546	PsiA protein; Region: PsiA; pfam06952
718274014547	Domain of unknown function (DUF932); Region: DUF932; cl12129
718274014548	Domain of unknown function (DUF932); Region: DUF932; cl12129
718274014549	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
718274014550	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
718274014551	N-acetyl-D-glucosamine binding site [chemical binding]; other site
718274014552	catalytic residue [active]
718274014553	conjugal transfer protein TraM; Provisional; Region: PRK13713
718274014554	conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719
718274014555	conjugal transfer protein TraY; Provisional; Region: PRK13740
718274014556	conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734
718274014557	conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707
718274014558	conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726
718274014559	conjugal transfer protein TraK; Provisional; Region: PRK13736
718274014560	TraK protein; Region: TraK; pfam06586
718274014561	conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729
718274014562	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
718274014563	TraP protein; Region: TraP; pfam07296
718274014564	conjugal transfer protein TrbD; Provisional; Region: PRK13724
718274014565	NTPase; Region: NTPase_1; cl17478
718274014566	conjugal transfer protein TraV; Provisional; Region: PRK13733
718274014567	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
718274014568	conjugal transfer protein TraR; Provisional; Region: PRK13715
718274014569	conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721
718274014570	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
718274014571	Domain of unknown function DUF87; Region: DUF87; pfam01935
718274014572	conjugal transfer protein TrbI; Provisional; Region: PRK13717
718274014573	conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738
718274014574	conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737
718274014575	conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730
718274014576	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
718274014577	active site
718274014578	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
718274014579	conjugal transfer protein TrbE; Provisional; Region: PRK13718
718274014580	conjugal pilus assembly protein TraF; Provisional; Region: PRK13703
718274014581	F plasmid transfer operon protein; Region: TraF; pfam13728
718274014582	conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727
718274014583	conjugal transfer protein TrbB; Provisional; Region: PRK13728
718274014584	conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723
718274014585	conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735
718274014586	Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624
718274014587	conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731
718274014588	Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818
718274014589	conjugal transfer protein TraD; Provisional; Region: PRK13700
718274014590	F sex factor protein N terminal; Region: TraD_N; pfam12615
718274014591	Bacterial conjugation protein TrwB,  ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127
718274014592	multimer interface [polypeptide binding]; other site
718274014593	Walker A motif; other site
718274014594	ATP binding site [chemical binding]; other site
718274014595	Walker B motif; other site
718274014596	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
718274014597	oligomeric interface; other site
718274014598	putative active site [active]
718274014599	homodimer interface [polypeptide binding]; other site
718274014600	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
718274014601	conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709
718274014602	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
718274014603	AAA domain; Region: AAA_30; pfam13604
718274014604	DNA helicase TraI; Region: TraI; pfam07057
718274014605	conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706
718274014606	conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754
718274014607	Fertility inhibition protein N terminal; Region: FinO_N; pfam12602
718274014608	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236
718274014609	putative kissing complex interaction region; other site
718274014610	putative RNA binding sites [nucleotide binding]; other site
718274014611	AAA domain; Region: AAA_25; pfam13481
718274014612	Hexameric Replicative Helicase RepA.  RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125
718274014613	Walker A motif; other site
718274014614	NTP binding site [chemical binding]; other site
718274014615	hexamer interface [polypeptide binding]; other site
718274014616	Walker B motif; other site
718274014617	Replication protein C (RepC); Region: RepC; pfam06504
718274014618	dihydropteroate synthase; Region: DHPS; TIGR01496
718274014619	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
718274014620	substrate binding pocket [chemical binding]; other site
718274014621	dimer interface [polypeptide binding]; other site
718274014622	inhibitor binding site; inhibition site
718274014623	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
718274014624	Phosphotransferase enzyme family; Region: APH; pfam01636
718274014625	active site
718274014626	ATP binding site [chemical binding]; other site
718274014627	antibiotic binding site [chemical binding]; other site
718274014628	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655
718274014629	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
718274014630	MobA/MobL family; Region: MobA_MobL; pfam03389