-- dump date 20140620_061659 -- class Genbank::misc_feature -- table misc_feature_note -- id note 936157000001 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 936157000002 carboxyltransferase (CT) interaction site; other site 936157000003 biotinylation site [posttranslational modification]; other site 936157000004 Oxaloacetate decarboxylase alpha chain;, Biotin-requiring enzyme, oadA: oxaloacetate decarboxylase alpha subunit, Conserved carboxylase region 936157000005 Oxaloacetate decarboxylase alpha chain;, HMGL-like, oadA: oxaloacetate decarboxylase alpha subunit, Aldolase-type TIM barrel 936157000006 Pyruvate carboxylase; Pyruvic carboxylase; PCB;, HMGL-like, oadA: oxaloacetate decarboxylase alpha subunit, Aldolase-type TIM barrel 936157000007 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 936157000008 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 936157000009 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 936157000010 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 936157000011 putative active site [active] 936157000012 (T/H)XGH motif; other site 936157000013 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 936157000014 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 936157000015 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 936157000016 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 936157000017 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 936157000018 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 936157000019 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 936157000020 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 936157000021 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 936157000022 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 936157000023 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 936157000024 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 936157000025 catalytic site [active] 936157000026 subunit interface [polypeptide binding]; other site 936157000027 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 936157000028 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936157000029 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 936157000030 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 936157000031 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936157000032 ATP-grasp domain; Region: ATP-grasp_4; cl17255 936157000033 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 936157000034 IMP binding site; other site 936157000035 dimer interface [polypeptide binding]; other site 936157000036 interdomain contacts; other site 936157000037 partial ornithine binding site; other site 936157000038 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 936157000039 carnitine operon protein CaiE; Provisional; Region: PRK13627 936157000040 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 936157000041 putative trimer interface [polypeptide binding]; other site 936157000042 putative metal binding site [ion binding]; other site 936157000043 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 936157000044 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 936157000045 substrate binding site [chemical binding]; other site 936157000046 oxyanion hole (OAH) forming residues; other site 936157000047 trimer interface [polypeptide binding]; other site 936157000048 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 936157000049 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 936157000050 acyl-activating enzyme (AAE) consensus motif; other site 936157000051 putative AMP binding site [chemical binding]; other site 936157000052 putative active site [active] 936157000053 putative CoA binding site [chemical binding]; other site 936157000054 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 936157000055 CoA-transferase family III; Region: CoA_transf_3; pfam02515 936157000056 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 936157000057 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 936157000058 active site 936157000059 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 936157000060 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 936157000061 Ligand binding site [chemical binding]; other site 936157000062 Electron transfer flavoprotein domain; Region: ETF; pfam01012 936157000063 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 936157000064 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 936157000065 Ligand binding site [chemical binding]; other site 936157000066 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 936157000067 putative oxidoreductase FixC; Provisional; Region: PRK10157 936157000068 ferredoxin-like protein FixX; Provisional; Region: PRK15449 936157000069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157000070 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 936157000071 putative substrate translocation pore; other site 936157000072 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 936157000073 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 936157000074 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 936157000075 Sulfatase; Region: Sulfatase; cl17466 936157000076 Sulfatase; Region: Sulfatase; cl17466 936157000077 Sulfatase; Region: Sulfatase; cl17466 936157000078 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 936157000079 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 936157000080 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 936157000081 TrkA-N domain; Region: TrkA_N; pfam02254 936157000082 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 936157000083 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 936157000084 folate binding site [chemical binding]; other site 936157000085 NADP+ binding site [chemical binding]; other site 936157000086 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 936157000087 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 936157000088 active site 936157000089 metal binding site [ion binding]; metal-binding site 936157000090 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 936157000091 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 936157000092 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 936157000093 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 936157000094 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 936157000095 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 936157000096 SurA N-terminal domain; Region: SurA_N; pfam09312 936157000097 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 936157000098 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 936157000099 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 936157000100 OstA-like protein; Region: OstA; pfam03968 936157000101 Organic solvent tolerance protein; Region: OstA_C; pfam04453 936157000102 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 936157000103 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 936157000104 putative metal binding site [ion binding]; other site 936157000105 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 936157000106 HSP70 interaction site [polypeptide binding]; other site 936157000107 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 936157000108 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 936157000109 active site 936157000110 ATP-dependent helicase HepA; Validated; Region: PRK04914 936157000111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936157000112 ATP binding site [chemical binding]; other site 936157000113 putative Mg++ binding site [ion binding]; other site 936157000114 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157000115 nucleotide binding region [chemical binding]; other site 936157000116 ATP-binding site [chemical binding]; other site 936157000117 DNA polymerase II; Reviewed; Region: PRK05762 936157000118 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 936157000119 active site 936157000120 catalytic site [active] 936157000121 substrate binding site [chemical binding]; other site 936157000122 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 936157000123 active site 936157000124 metal-binding site 936157000125 Transposase IS200 like; Region: Y1_Tnp; pfam01797 936157000126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 936157000127 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 936157000128 Probable transposase; Region: OrfB_IS605; pfam01385 936157000129 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 936157000130 Uncharacterized conserved protein [Function unknown]; Region: COG1434 936157000131 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 936157000132 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 936157000133 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 936157000134 intersubunit interface [polypeptide binding]; other site 936157000135 active site 936157000136 Zn2+ binding site [ion binding]; other site 936157000137 L-arabinose isomerase; Provisional; Region: PRK02929 936157000138 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 936157000139 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 936157000140 trimer interface [polypeptide binding]; other site 936157000141 putative substrate binding site [chemical binding]; other site 936157000142 putative metal binding site [ion binding]; other site 936157000143 ribulokinase; Provisional; Region: PRK04123 936157000144 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 936157000145 N- and C-terminal domain interface [polypeptide binding]; other site 936157000146 active site 936157000147 MgATP binding site [chemical binding]; other site 936157000148 catalytic site [active] 936157000149 metal binding site [ion binding]; metal-binding site 936157000150 carbohydrate binding site [chemical binding]; other site 936157000151 homodimer interface [polypeptide binding]; other site 936157000152 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 936157000153 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 936157000154 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157000155 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157000156 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 936157000157 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 936157000158 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 936157000159 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 936157000160 Walker A/P-loop; other site 936157000161 ATP binding site [chemical binding]; other site 936157000162 Q-loop/lid; other site 936157000163 ABC transporter signature motif; other site 936157000164 Walker B; other site 936157000165 D-loop; other site 936157000166 H-loop/switch region; other site 936157000167 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 936157000168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157000169 dimer interface [polypeptide binding]; other site 936157000170 conserved gate region; other site 936157000171 putative PBP binding loops; other site 936157000172 ABC-ATPase subunit interface; other site 936157000173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157000174 dimer interface [polypeptide binding]; other site 936157000175 conserved gate region; other site 936157000176 putative PBP binding loops; other site 936157000177 ABC-ATPase subunit interface; other site 936157000178 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 936157000179 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 936157000180 transcriptional regulator SgrR; Provisional; Region: PRK13626 936157000181 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 936157000182 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 936157000183 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 936157000184 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 936157000185 substrate binding site [chemical binding]; other site 936157000186 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 936157000187 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 936157000188 substrate binding site [chemical binding]; other site 936157000189 ligand binding site [chemical binding]; other site 936157000190 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 936157000191 tartrate dehydrogenase; Region: TTC; TIGR02089 936157000192 2-isopropylmalate synthase; Validated; Region: PRK00915 936157000193 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 936157000194 active site 936157000195 catalytic residues [active] 936157000196 metal binding site [ion binding]; metal-binding site 936157000197 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 936157000198 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 936157000199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157000200 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 936157000201 putative substrate binding pocket [chemical binding]; other site 936157000202 putative dimerization interface [polypeptide binding]; other site 936157000203 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 936157000204 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 936157000205 PYR/PP interface [polypeptide binding]; other site 936157000206 dimer interface [polypeptide binding]; other site 936157000207 TPP binding site [chemical binding]; other site 936157000208 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 936157000209 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 936157000210 TPP-binding site [chemical binding]; other site 936157000211 dimer interface [polypeptide binding]; other site 936157000212 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 936157000213 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 936157000214 putative valine binding site [chemical binding]; other site 936157000215 dimer interface [polypeptide binding]; other site 936157000216 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 936157000217 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 936157000218 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157000219 DNA binding site [nucleotide binding] 936157000220 domain linker motif; other site 936157000221 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 936157000222 dimerization interface [polypeptide binding]; other site 936157000223 ligand binding site [chemical binding]; other site 936157000224 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 936157000225 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 936157000226 cell division protein FtsL; Provisional; Region: PRK10772 936157000227 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 936157000228 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936157000229 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936157000230 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 936157000231 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 936157000232 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936157000233 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936157000234 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 936157000235 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 936157000236 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936157000237 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936157000238 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 936157000239 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 936157000240 Mg++ binding site [ion binding]; other site 936157000241 putative catalytic motif [active] 936157000242 putative substrate binding site [chemical binding]; other site 936157000243 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 936157000244 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936157000245 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936157000246 cell division protein FtsW; Provisional; Region: PRK10774 936157000247 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 936157000248 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 936157000249 active site 936157000250 homodimer interface [polypeptide binding]; other site 936157000251 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 936157000252 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 936157000253 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936157000254 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936157000255 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 936157000256 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 936157000257 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 936157000258 cell division protein FtsQ; Provisional; Region: PRK10775 936157000259 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 936157000260 Cell division protein FtsQ; Region: FtsQ; pfam03799 936157000261 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 936157000262 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936157000263 Cell division protein FtsA; Region: FtsA; pfam14450 936157000264 cell division protein FtsZ; Validated; Region: PRK09330 936157000265 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 936157000266 nucleotide binding site [chemical binding]; other site 936157000267 SulA interaction site; other site 936157000268 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 936157000269 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 936157000270 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 936157000271 SecA regulator SecM; Provisional; Region: PRK02943 936157000272 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 936157000273 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 936157000274 SEC-C motif; Region: SEC-C; pfam02810 936157000275 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 936157000276 active site 936157000277 8-oxo-dGMP binding site [chemical binding]; other site 936157000278 nudix motif; other site 936157000279 metal binding site [ion binding]; metal-binding site 936157000280 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936157000281 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936157000282 active site 936157000283 catalytic tetrad [active] 936157000284 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157000285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157000286 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 936157000287 putative effector binding pocket; other site 936157000288 putative dimerization interface [polypeptide binding]; other site 936157000289 DNA gyrase inhibitor; Reviewed; Region: PRK00418 936157000290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 936157000291 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 936157000292 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 936157000293 CoA-binding site [chemical binding]; other site 936157000294 ATP-binding [chemical binding]; other site 936157000295 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 936157000296 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 936157000297 active site 936157000298 type IV pilin biogenesis protein; Provisional; Region: PRK10573 936157000299 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 936157000300 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 936157000301 hypothetical protein; Provisional; Region: PRK10436 936157000302 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 936157000303 Walker A motif; other site 936157000304 ATP binding site [chemical binding]; other site 936157000305 Walker B motif; other site 936157000306 putative major pilin subunit; Provisional; Region: PRK10574 936157000307 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 936157000308 Pilin (bacterial filament); Region: Pilin; pfam00114 936157000309 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 936157000310 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 936157000311 dimerization interface [polypeptide binding]; other site 936157000312 active site 936157000313 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 936157000314 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 936157000315 amidase catalytic site [active] 936157000316 Zn binding residues [ion binding]; other site 936157000317 substrate binding site [chemical binding]; other site 936157000318 regulatory protein AmpE; Provisional; Region: PRK10987 936157000319 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 936157000320 active site 936157000321 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 936157000322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157000323 putative substrate translocation pore; other site 936157000324 aromatic amino acid transporter; Provisional; Region: PRK10238 936157000325 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 936157000326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157000327 DNA-binding site [nucleotide binding]; DNA binding site 936157000328 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 936157000329 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 936157000330 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 936157000331 dimer interface [polypeptide binding]; other site 936157000332 TPP-binding site [chemical binding]; other site 936157000333 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 936157000334 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 936157000335 E3 interaction surface; other site 936157000336 lipoyl attachment site [posttranslational modification]; other site 936157000337 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 936157000338 E3 interaction surface; other site 936157000339 lipoyl attachment site [posttranslational modification]; other site 936157000340 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 936157000341 E3 interaction surface; other site 936157000342 lipoyl attachment site [posttranslational modification]; other site 936157000343 e3 binding domain; Region: E3_binding; pfam02817 936157000344 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 936157000345 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 936157000346 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 936157000347 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936157000348 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 936157000349 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 936157000350 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 936157000351 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 936157000352 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 936157000353 substrate binding site [chemical binding]; other site 936157000354 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 936157000355 substrate binding site [chemical binding]; other site 936157000356 ligand binding site [chemical binding]; other site 936157000357 putative inner membrane protein; Provisional; Region: PRK09823 936157000358 Low molecular weight phosphatase family; Region: LMWPc; cl00105 936157000359 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 936157000360 active site 936157000361 hypothetical protein; Provisional; Region: PRK05248 936157000362 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 936157000363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 936157000364 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 936157000365 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 936157000366 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936157000367 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 936157000368 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157000369 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 936157000370 spermidine synthase; Provisional; Region: PRK00811 936157000371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157000372 S-adenosylmethionine binding site [chemical binding]; other site 936157000373 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 936157000374 multicopper oxidase; Provisional; Region: PRK10965 936157000375 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 936157000376 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 936157000377 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 936157000378 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 936157000379 Trp docking motif [polypeptide binding]; other site 936157000380 putative active site [active] 936157000381 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936157000382 active site 936157000383 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 936157000384 active site clefts [active] 936157000385 zinc binding site [ion binding]; other site 936157000386 dimer interface [polypeptide binding]; other site 936157000387 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 936157000388 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936157000389 Walker A/P-loop; other site 936157000390 ATP binding site [chemical binding]; other site 936157000391 Q-loop/lid; other site 936157000392 ABC transporter signature motif; other site 936157000393 Walker B; other site 936157000394 D-loop; other site 936157000395 H-loop/switch region; other site 936157000396 inner membrane transport permease; Provisional; Region: PRK15066 936157000397 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 936157000398 putative fimbrial protein StiH; Provisional; Region: PRK15297 936157000399 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 936157000400 PapC N-terminal domain; Region: PapC_N; pfam13954 936157000401 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 936157000402 PapC C-terminal domain; Region: PapC_C; pfam13953 936157000403 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 936157000404 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 936157000405 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 936157000406 fimbrial protein StiA; Provisional; Region: PRK15300 936157000407 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 936157000408 active pocket/dimerization site; other site 936157000409 active site 936157000410 phosphorylation site [posttranslational modification] 936157000411 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 936157000412 putative active site [active] 936157000413 putative metal binding site [ion binding]; other site 936157000414 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 936157000415 tetramerization interface [polypeptide binding]; other site 936157000416 active site 936157000417 Pantoate-beta-alanine ligase; Region: PanC; cd00560 936157000418 pantoate--beta-alanine ligase; Region: panC; TIGR00018 936157000419 active site 936157000420 ATP-binding site [chemical binding]; other site 936157000421 pantoate-binding site; other site 936157000422 HXXH motif; other site 936157000423 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 936157000424 oligomerization interface [polypeptide binding]; other site 936157000425 active site 936157000426 metal binding site [ion binding]; metal-binding site 936157000427 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 936157000428 catalytic center binding site [active] 936157000429 ATP binding site [chemical binding]; other site 936157000430 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 936157000431 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 936157000432 active site 936157000433 NTP binding site [chemical binding]; other site 936157000434 metal binding triad [ion binding]; metal-binding site 936157000435 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 936157000436 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 936157000437 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 936157000438 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 936157000439 active site 936157000440 nucleotide binding site [chemical binding]; other site 936157000441 HIGH motif; other site 936157000442 KMSKS motif; other site 936157000443 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 936157000444 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 936157000445 2'-5' RNA ligase; Provisional; Region: PRK15124 936157000446 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 936157000447 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 936157000448 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 936157000449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936157000450 ATP binding site [chemical binding]; other site 936157000451 putative Mg++ binding site [ion binding]; other site 936157000452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157000453 nucleotide binding region [chemical binding]; other site 936157000454 ATP-binding site [chemical binding]; other site 936157000455 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 936157000456 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 936157000457 Transglycosylase; Region: Transgly; pfam00912 936157000458 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 936157000459 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 936157000460 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 936157000461 N-terminal plug; other site 936157000462 ligand-binding site [chemical binding]; other site 936157000463 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 936157000464 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 936157000465 Walker A/P-loop; other site 936157000466 ATP binding site [chemical binding]; other site 936157000467 Q-loop/lid; other site 936157000468 ABC transporter signature motif; other site 936157000469 Walker B; other site 936157000470 D-loop; other site 936157000471 H-loop/switch region; other site 936157000472 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 936157000473 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 936157000474 siderophore binding site; other site 936157000475 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 936157000476 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936157000477 ABC-ATPase subunit interface; other site 936157000478 dimer interface [polypeptide binding]; other site 936157000479 putative PBP binding regions; other site 936157000480 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936157000481 ABC-ATPase subunit interface; other site 936157000482 dimer interface [polypeptide binding]; other site 936157000483 putative PBP binding regions; other site 936157000484 putative fimbrial subunit StfA; Provisional; Region: PRK15283 936157000485 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 936157000486 PapC N-terminal domain; Region: PapC_N; pfam13954 936157000487 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 936157000488 PapC C-terminal domain; Region: PapC_C; pfam13953 936157000489 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 936157000490 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 936157000491 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 936157000492 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 936157000493 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 936157000494 Fimbrial protein; Region: Fimbrial; cl01416 936157000495 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 936157000496 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 936157000497 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936157000498 inhibitor-cofactor binding pocket; inhibition site 936157000499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157000500 catalytic residue [active] 936157000501 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 936157000502 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 936157000503 Cl- selectivity filter; other site 936157000504 Cl- binding residues [ion binding]; other site 936157000505 pore gating glutamate residue; other site 936157000506 dimer interface [polypeptide binding]; other site 936157000507 H+/Cl- coupling transport residue; other site 936157000508 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 936157000509 hypothetical protein; Provisional; Region: PRK10578 936157000510 UPF0126 domain; Region: UPF0126; pfam03458 936157000511 UPF0126 domain; Region: UPF0126; pfam03458 936157000512 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 936157000513 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 936157000514 cobalamin binding residues [chemical binding]; other site 936157000515 putative BtuC binding residues; other site 936157000516 dimer interface [polypeptide binding]; other site 936157000517 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 936157000518 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 936157000519 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 936157000520 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936157000521 Zn2+ binding site [ion binding]; other site 936157000522 Mg2+ binding site [ion binding]; other site 936157000523 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 936157000524 serine endoprotease; Provisional; Region: PRK10942 936157000525 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 936157000526 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 936157000527 protein binding site [polypeptide binding]; other site 936157000528 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 936157000529 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 936157000530 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 936157000531 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 936157000532 hypothetical protein; Provisional; Region: PRK13677 936157000533 shikimate transporter; Provisional; Region: PRK09952 936157000534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157000535 putative substrate translocation pore; other site 936157000536 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 936157000537 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 936157000538 trimer interface [polypeptide binding]; other site 936157000539 active site 936157000540 substrate binding site [chemical binding]; other site 936157000541 CoA binding site [chemical binding]; other site 936157000542 PII uridylyl-transferase; Provisional; Region: PRK05007 936157000543 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 936157000544 metal binding triad; other site 936157000545 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 936157000546 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936157000547 Zn2+ binding site [ion binding]; other site 936157000548 Mg2+ binding site [ion binding]; other site 936157000549 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 936157000550 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 936157000551 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 936157000552 active site 936157000553 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 936157000554 rRNA interaction site [nucleotide binding]; other site 936157000555 S8 interaction site; other site 936157000556 putative laminin-1 binding site; other site 936157000557 elongation factor Ts; Provisional; Region: tsf; PRK09377 936157000558 UBA/TS-N domain; Region: UBA; pfam00627 936157000559 Elongation factor TS; Region: EF_TS; pfam00889 936157000560 Elongation factor TS; Region: EF_TS; pfam00889 936157000561 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 936157000562 putative nucleotide binding site [chemical binding]; other site 936157000563 uridine monophosphate binding site [chemical binding]; other site 936157000564 homohexameric interface [polypeptide binding]; other site 936157000565 ribosome recycling factor; Reviewed; Region: frr; PRK00083 936157000566 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 936157000567 hinge region; other site 936157000568 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 936157000569 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 936157000570 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 936157000571 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 936157000572 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 936157000573 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 936157000574 catalytic residue [active] 936157000575 putative FPP diphosphate binding site; other site 936157000576 putative FPP binding hydrophobic cleft; other site 936157000577 dimer interface [polypeptide binding]; other site 936157000578 putative IPP diphosphate binding site; other site 936157000579 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 936157000580 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 936157000581 zinc metallopeptidase RseP; Provisional; Region: PRK10779 936157000582 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 936157000583 active site 936157000584 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 936157000585 protein binding site [polypeptide binding]; other site 936157000586 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 936157000587 protein binding site [polypeptide binding]; other site 936157000588 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 936157000589 putative substrate binding region [chemical binding]; other site 936157000590 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 936157000591 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 936157000592 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 936157000593 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 936157000594 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 936157000595 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 936157000596 Surface antigen; Region: Bac_surface_Ag; pfam01103 936157000597 periplasmic chaperone; Provisional; Region: PRK10780 936157000598 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 936157000599 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 936157000600 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 936157000601 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 936157000602 trimer interface [polypeptide binding]; other site 936157000603 active site 936157000604 UDP-GlcNAc binding site [chemical binding]; other site 936157000605 lipid binding site [chemical binding]; lipid-binding site 936157000606 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 936157000607 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 936157000608 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 936157000609 active site 936157000610 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 936157000611 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 936157000612 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 936157000613 RNA/DNA hybrid binding site [nucleotide binding]; other site 936157000614 active site 936157000615 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 936157000616 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 936157000617 putative active site [active] 936157000618 putative PHP Thumb interface [polypeptide binding]; other site 936157000619 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 936157000620 generic binding surface II; other site 936157000621 generic binding surface I; other site 936157000622 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 936157000623 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 936157000624 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 936157000625 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 936157000626 putative sugar binding site [chemical binding]; other site 936157000627 catalytic residues [active] 936157000628 PKD domain; Region: PKD; pfam00801 936157000629 lysine decarboxylase LdcC; Provisional; Region: PRK15399 936157000630 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 936157000631 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 936157000632 homodimer interface [polypeptide binding]; other site 936157000633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157000634 catalytic residue [active] 936157000635 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 936157000636 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 936157000637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936157000638 putative metal binding site [ion binding]; other site 936157000639 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 936157000640 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 936157000641 Ligand Binding Site [chemical binding]; other site 936157000642 TilS substrate binding domain; Region: TilS; pfam09179 936157000643 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 936157000644 Rho-binding antiterminator; Provisional; Region: PRK11625 936157000645 hypothetical protein; Provisional; Region: PRK04964 936157000646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 936157000647 hypothetical protein; Provisional; Region: PRK09256 936157000648 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 936157000649 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 936157000650 NlpE N-terminal domain; Region: NlpE; pfam04170 936157000651 prolyl-tRNA synthetase; Provisional; Region: PRK09194 936157000652 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 936157000653 dimer interface [polypeptide binding]; other site 936157000654 motif 1; other site 936157000655 active site 936157000656 motif 2; other site 936157000657 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 936157000658 putative deacylase active site [active] 936157000659 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 936157000660 active site 936157000661 motif 3; other site 936157000662 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 936157000663 anticodon binding site; other site 936157000664 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 936157000665 homodimer interaction site [polypeptide binding]; other site 936157000666 cofactor binding site; other site 936157000667 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 936157000668 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 936157000669 lipoprotein, YaeC family; Region: TIGR00363 936157000670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157000671 dimer interface [polypeptide binding]; other site 936157000672 conserved gate region; other site 936157000673 ABC-ATPase subunit interface; other site 936157000674 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 936157000675 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 936157000676 Walker A/P-loop; other site 936157000677 ATP binding site [chemical binding]; other site 936157000678 Q-loop/lid; other site 936157000679 ABC transporter signature motif; other site 936157000680 Walker B; other site 936157000681 D-loop; other site 936157000682 H-loop/switch region; other site 936157000683 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 936157000684 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 936157000685 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157000686 active site 936157000687 motif I; other site 936157000688 motif II; other site 936157000689 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936157000690 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936157000691 active site 936157000692 catalytic tetrad [active] 936157000693 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157000694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157000695 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 936157000696 putative effector binding pocket; other site 936157000697 dimerization interface [polypeptide binding]; other site 936157000698 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936157000699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157000700 putative substrate translocation pore; other site 936157000701 hypothetical protein; Provisional; Region: PRK05421 936157000702 putative catalytic site [active] 936157000703 putative metal binding site [ion binding]; other site 936157000704 putative phosphate binding site [ion binding]; other site 936157000705 putative catalytic site [active] 936157000706 putative phosphate binding site [ion binding]; other site 936157000707 putative metal binding site [ion binding]; other site 936157000708 Methyltransferase domain; Region: Methyltransf_23; pfam13489 936157000709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157000710 S-adenosylmethionine binding site [chemical binding]; other site 936157000711 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 936157000712 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936157000713 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936157000714 catalytic residue [active] 936157000715 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936157000716 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936157000717 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 936157000718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157000719 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 936157000720 RNA/DNA hybrid binding site [nucleotide binding]; other site 936157000721 active site 936157000722 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 936157000723 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 936157000724 active site 936157000725 catalytic site [active] 936157000726 substrate binding site [chemical binding]; other site 936157000727 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 936157000728 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 936157000729 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 936157000730 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 936157000731 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 936157000732 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 936157000733 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 936157000734 ImpE protein; Region: ImpE; pfam07024 936157000735 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 936157000736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157000737 Walker A motif; other site 936157000738 ATP binding site [chemical binding]; other site 936157000739 Walker B motif; other site 936157000740 arginine finger; other site 936157000741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157000742 Walker A motif; other site 936157000743 ATP binding site [chemical binding]; other site 936157000744 Walker B motif; other site 936157000745 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 936157000746 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 936157000747 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 936157000748 Protein of unknown function (DUF877); Region: DUF877; pfam05943 936157000749 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 936157000750 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 936157000751 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 936157000752 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 936157000753 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 936157000754 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 936157000755 hypothetical protein; Provisional; Region: PRK08126 936157000756 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 936157000757 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 936157000758 ligand binding site [chemical binding]; other site 936157000759 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 936157000760 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 936157000761 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 936157000762 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 936157000763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 936157000764 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 936157000765 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 936157000766 Uncharacterized conserved protein [Function unknown]; Region: COG5435 936157000767 PAAR motif; Region: PAAR_motif; pfam05488 936157000768 RHS Repeat; Region: RHS_repeat; pfam05593 936157000769 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 936157000770 RHS Repeat; Region: RHS_repeat; pfam05593 936157000771 RHS Repeat; Region: RHS_repeat; pfam05593 936157000772 RHS Repeat; Region: RHS_repeat; cl11982 936157000773 RHS protein; Region: RHS; pfam03527 936157000774 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 936157000775 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 936157000776 RHS Repeat; Region: RHS_repeat; cl11982 936157000777 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 936157000778 RHS Repeat; Region: RHS_repeat; pfam05593 936157000779 RHS Repeat; Region: RHS_repeat; cl11982 936157000780 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 936157000781 RHS Repeat; Region: RHS_repeat; pfam05593 936157000782 RHS Repeat; Region: RHS_repeat; pfam05593 936157000783 RHS Repeat; Region: RHS_repeat; pfam05593 936157000784 RHS Repeat; Region: RHS_repeat; pfam05593 936157000785 RHS Repeat; Region: RHS_repeat; cl11982 936157000786 RHS protein; Region: RHS; pfam03527 936157000787 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 936157000788 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 936157000789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 936157000790 Integrase core domain; Region: rve_3; pfam13683 936157000791 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 936157000792 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 936157000793 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 936157000794 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 936157000795 PapC N-terminal domain; Region: PapC_N; pfam13954 936157000796 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 936157000797 PapC C-terminal domain; Region: PapC_C; pfam13953 936157000798 putative pilin structural protein SafD; Provisional; Region: PRK15222 936157000799 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 936157000800 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 936157000801 putative active site [active] 936157000802 putative metal binding site [ion binding]; other site 936157000803 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157000804 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157000805 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 936157000806 dimerization interface [polypeptide binding]; other site 936157000807 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 936157000808 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 936157000809 dimer interface [polypeptide binding]; other site 936157000810 C-N hydrolase family amidase; Provisional; Region: PRK10438 936157000811 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 936157000812 putative active site [active] 936157000813 catalytic triad [active] 936157000814 dimer interface [polypeptide binding]; other site 936157000815 multimer interface [polypeptide binding]; other site 936157000816 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 936157000817 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 936157000818 active site 936157000819 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 936157000820 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 936157000821 dimer interface [polypeptide binding]; other site 936157000822 active site 936157000823 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 936157000824 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 936157000825 putative active site [active] 936157000826 putative dimer interface [polypeptide binding]; other site 936157000827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 936157000828 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 936157000829 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 936157000830 active site 936157000831 DNA polymerase IV; Validated; Region: PRK02406 936157000832 DNA binding site [nucleotide binding] 936157000833 hypothetical protein; Reviewed; Region: PRK09588 936157000834 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 936157000835 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 936157000836 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 936157000837 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 936157000838 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 936157000839 metal binding site [ion binding]; metal-binding site 936157000840 dimer interface [polypeptide binding]; other site 936157000841 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936157000842 active site 936157000843 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 936157000844 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 936157000845 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 936157000846 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 936157000847 trimer interface [polypeptide binding]; other site 936157000848 eyelet of channel; other site 936157000849 gamma-glutamyl kinase; Provisional; Region: PRK05429 936157000850 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 936157000851 nucleotide binding site [chemical binding]; other site 936157000852 homotetrameric interface [polypeptide binding]; other site 936157000853 putative phosphate binding site [ion binding]; other site 936157000854 putative allosteric binding site; other site 936157000855 PUA domain; Region: PUA; pfam01472 936157000856 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 936157000857 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 936157000858 putative catalytic cysteine [active] 936157000859 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 936157000860 HTH-like domain; Region: HTH_21; pfam13276 936157000861 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 936157000862 Integrase core domain; Region: rve; pfam00665 936157000863 Integrase core domain; Region: rve_2; pfam13333 936157000864 Transposase; Region: HTH_Tnp_1; cl17663 936157000865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 936157000866 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 936157000867 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 936157000868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 936157000869 Nucleoside recognition; Region: Gate; pfam07670 936157000870 hypothetical protein; Provisional; Region: PRK10519 936157000871 isoaspartyl dipeptidase; Provisional; Region: PRK10657 936157000872 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 936157000873 active site 936157000874 cell density-dependent motility repressor; Provisional; Region: PRK10082 936157000875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157000876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936157000877 dimerization interface [polypeptide binding]; other site 936157000878 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 936157000879 aspartate racemase; Region: asp_race; TIGR00035 936157000880 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 936157000881 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 936157000882 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 936157000883 active site 936157000884 HIGH motif; other site 936157000885 dimer interface [polypeptide binding]; other site 936157000886 KMSKS motif; other site 936157000887 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 936157000888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157000889 DNA-binding site [nucleotide binding]; DNA binding site 936157000890 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 936157000891 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 936157000892 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 936157000893 Uncharacterized conserved protein [Function unknown]; Region: COG3439 936157000894 putative transposase OrfB; Reviewed; Region: PHA02517 936157000895 HTH-like domain; Region: HTH_21; pfam13276 936157000896 Integrase core domain; Region: rve; pfam00665 936157000897 Integrase core domain; Region: rve_2; pfam13333 936157000898 Transposase; Region: HTH_Tnp_1; cl17663 936157000899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 936157000900 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 936157000901 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 936157000902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157000903 putative substrate translocation pore; other site 936157000904 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936157000905 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 936157000906 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 936157000907 substrate binding site [chemical binding]; other site 936157000908 ligand binding site [chemical binding]; other site 936157000909 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 936157000910 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 936157000911 hypothetical protein; Provisional; Region: PRK14812 936157000912 substrate binding site [chemical binding]; other site 936157000913 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 936157000914 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 936157000915 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 936157000916 transcriptional activator TtdR; Provisional; Region: PRK09801 936157000917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157000918 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 936157000919 putative effector binding pocket; other site 936157000920 putative dimerization interface [polypeptide binding]; other site 936157000921 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 936157000922 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 936157000923 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 936157000924 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 936157000925 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 936157000926 PapC N-terminal domain; Region: PapC_N; pfam13954 936157000927 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 936157000928 PapC C-terminal domain; Region: PapC_C; pfam13953 936157000929 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 936157000930 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 936157000931 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 936157000932 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 936157000933 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 936157000934 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 936157000935 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157000936 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 936157000937 DNA binding site [nucleotide binding] 936157000938 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 936157000939 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 936157000940 DNA binding residues [nucleotide binding] 936157000941 dimerization interface [polypeptide binding]; other site 936157000942 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 936157000943 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 936157000944 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 936157000945 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 936157000946 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936157000947 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157000948 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 936157000949 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 936157000950 metal-binding site [ion binding] 936157000951 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936157000952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157000953 motif II; other site 936157000954 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 936157000955 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 936157000956 DNA binding residues [nucleotide binding] 936157000957 dimer interface [polypeptide binding]; other site 936157000958 copper binding site [ion binding]; other site 936157000959 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 936157000960 metal-binding site [ion binding] 936157000961 putative sialic acid transporter; Region: 2A0112; TIGR00891 936157000962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157000963 putative substrate translocation pore; other site 936157000964 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 936157000965 DNA methylase; Region: N6_N4_Mtase; cl17433 936157000966 DNA methylase; Region: N6_N4_Mtase; pfam01555 936157000967 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 936157000968 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 936157000969 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 936157000970 VRR-NUC domain; Region: VRR_NUC; pfam08774 936157000971 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 936157000972 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 936157000973 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 936157000974 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 936157000975 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936157000976 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 936157000977 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 936157000978 N-terminal plug; other site 936157000979 ligand-binding site [chemical binding]; other site 936157000980 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 936157000981 hypothetical protein; Provisional; Region: PRK09929 936157000982 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 936157000983 Propionate catabolism activator; Region: PrpR_N; pfam06506 936157000984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157000985 Walker A motif; other site 936157000986 ATP binding site [chemical binding]; other site 936157000987 Walker B motif; other site 936157000988 arginine finger; other site 936157000989 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 936157000990 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 936157000991 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 936157000992 tetramer interface [polypeptide binding]; other site 936157000993 active site 936157000994 Mg2+/Mn2+ binding site [ion binding]; other site 936157000995 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 936157000996 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 936157000997 dimer interface [polypeptide binding]; other site 936157000998 active site 936157000999 citrylCoA binding site [chemical binding]; other site 936157001000 oxalacetate/citrate binding site [chemical binding]; other site 936157001001 coenzyme A binding site [chemical binding]; other site 936157001002 catalytic triad [active] 936157001003 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 936157001004 2-methylcitrate dehydratase; Region: prpD; TIGR02330 936157001005 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 936157001006 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 936157001007 acyl-activating enzyme (AAE) consensus motif; other site 936157001008 AMP binding site [chemical binding]; other site 936157001009 active site 936157001010 CoA binding site [chemical binding]; other site 936157001011 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 936157001012 dimer interface [polypeptide binding]; other site 936157001013 active site 936157001014 Schiff base residues; other site 936157001015 putative uncharacterized protein yaiT; Flags: Precursor 936157001016 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 936157001017 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 936157001018 Autotransporter beta-domain; Region: Autotransporter; pfam03797 936157001019 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 936157001020 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 936157001021 ligand binding site [chemical binding]; other site 936157001022 flexible hinge region; other site 936157001023 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 936157001024 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 936157001025 microcin B17 transporter; Reviewed; Region: PRK11098 936157001026 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 936157001027 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 936157001028 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 936157001029 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 936157001030 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 936157001031 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 936157001032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 936157001033 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 936157001034 drug efflux system protein MdtG; Provisional; Region: PRK09874 936157001035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157001036 putative substrate translocation pore; other site 936157001037 anti-RssB factor; Provisional; Region: PRK10244 936157001038 hypothetical protein; Provisional; Region: PRK11505 936157001039 psiF repeat; Region: PsiF_repeat; pfam07769 936157001040 psiF repeat; Region: PsiF_repeat; pfam07769 936157001041 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 936157001042 MASE2 domain; Region: MASE2; pfam05230 936157001043 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936157001044 metal binding site [ion binding]; metal-binding site 936157001045 active site 936157001046 I-site; other site 936157001047 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 936157001048 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 936157001049 hypothetical protein; Validated; Region: PRK00124 936157001050 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 936157001051 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 936157001052 ADP binding site [chemical binding]; other site 936157001053 magnesium binding site [ion binding]; other site 936157001054 putative shikimate binding site; other site 936157001055 hypothetical protein; Provisional; Region: PRK10380 936157001056 hypothetical protein; Provisional; Region: PRK10481 936157001057 hypothetical protein; Provisional; Region: PRK10579 936157001058 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 936157001059 fructokinase; Reviewed; Region: PRK09557 936157001060 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936157001061 nucleotide binding site [chemical binding]; other site 936157001062 MFS transport protein AraJ; Provisional; Region: PRK10091 936157001063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157001064 putative substrate translocation pore; other site 936157001065 exonuclease subunit SbcC; Provisional; Region: PRK10246 936157001066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157001067 Walker A/P-loop; other site 936157001068 ATP binding site [chemical binding]; other site 936157001069 Q-loop/lid; other site 936157001070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157001071 ABC transporter signature motif; other site 936157001072 Walker B; other site 936157001073 D-loop; other site 936157001074 H-loop/switch region; other site 936157001075 exonuclease subunit SbcD; Provisional; Region: PRK10966 936157001076 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 936157001077 active site 936157001078 metal binding site [ion binding]; metal-binding site 936157001079 DNA binding site [nucleotide binding] 936157001080 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 936157001081 transcriptional regulator PhoB; Provisional; Region: PRK10161 936157001082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157001083 active site 936157001084 phosphorylation site [posttranslational modification] 936157001085 intermolecular recognition site; other site 936157001086 dimerization interface [polypeptide binding]; other site 936157001087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157001088 DNA binding site [nucleotide binding] 936157001089 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 936157001090 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 936157001091 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936157001092 putative active site [active] 936157001093 heme pocket [chemical binding]; other site 936157001094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157001095 dimer interface [polypeptide binding]; other site 936157001096 phosphorylation site [posttranslational modification] 936157001097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157001098 ATP binding site [chemical binding]; other site 936157001099 Mg2+ binding site [ion binding]; other site 936157001100 G-X-G motif; other site 936157001101 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 936157001102 putative proline-specific permease; Provisional; Region: proY; PRK10580 936157001103 maltodextrin glucosidase; Provisional; Region: PRK10785 936157001104 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 936157001105 homodimer interface [polypeptide binding]; other site 936157001106 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 936157001107 active site 936157001108 homodimer interface [polypeptide binding]; other site 936157001109 catalytic site [active] 936157001110 peroxidase; Provisional; Region: PRK15000 936157001111 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 936157001112 dimer interface [polypeptide binding]; other site 936157001113 decamer (pentamer of dimers) interface [polypeptide binding]; other site 936157001114 catalytic triad [active] 936157001115 peroxidatic and resolving cysteines [active] 936157001116 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 936157001117 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 936157001118 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 936157001119 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 936157001120 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 936157001121 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 936157001122 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 936157001123 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 936157001124 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 936157001125 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 936157001126 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 936157001127 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 936157001128 Protein export membrane protein; Region: SecD_SecF; pfam02355 936157001129 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 936157001130 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936157001131 Predicted transcriptional regulator [Transcription]; Region: COG2378 936157001132 HTH domain; Region: HTH_11; pfam08279 936157001133 WYL domain; Region: WYL; pfam13280 936157001134 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 936157001135 active site 936157001136 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 936157001137 hypothetical protein; Provisional; Region: PRK11530 936157001138 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 936157001139 ATP cone domain; Region: ATP-cone; pfam03477 936157001140 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 936157001141 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 936157001142 catalytic motif [active] 936157001143 Zn binding site [ion binding]; other site 936157001144 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 936157001145 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 936157001146 homopentamer interface [polypeptide binding]; other site 936157001147 active site 936157001148 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 936157001149 putative RNA binding site [nucleotide binding]; other site 936157001150 thiamine monophosphate kinase; Provisional; Region: PRK05731 936157001151 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 936157001152 ATP binding site [chemical binding]; other site 936157001153 dimerization interface [polypeptide binding]; other site 936157001154 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 936157001155 tetramer interfaces [polypeptide binding]; other site 936157001156 binuclear metal-binding site [ion binding]; other site 936157001157 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936157001158 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936157001159 active site 936157001160 catalytic tetrad [active] 936157001161 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 936157001162 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 936157001163 TPP-binding site; other site 936157001164 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 936157001165 PYR/PP interface [polypeptide binding]; other site 936157001166 dimer interface [polypeptide binding]; other site 936157001167 TPP binding site [chemical binding]; other site 936157001168 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 936157001169 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 936157001170 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 936157001171 substrate binding pocket [chemical binding]; other site 936157001172 chain length determination region; other site 936157001173 substrate-Mg2+ binding site; other site 936157001174 catalytic residues [active] 936157001175 aspartate-rich region 1; other site 936157001176 active site lid residues [active] 936157001177 aspartate-rich region 2; other site 936157001178 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 936157001179 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 936157001180 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 936157001181 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 936157001182 Ligand Binding Site [chemical binding]; other site 936157001183 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 936157001184 active site residue [active] 936157001185 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 936157001186 Transcriptional regulator [Transcription]; Region: IclR; COG1414 936157001187 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 936157001188 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157001189 molybdopterin cofactor binding site; other site 936157001190 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 936157001191 molybdopterin cofactor binding site; other site 936157001192 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 936157001193 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 936157001194 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 936157001195 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 936157001196 conserved cys residue [active] 936157001197 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 936157001198 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 936157001199 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 936157001200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 936157001201 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 936157001202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157001203 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936157001204 putative substrate translocation pore; other site 936157001205 Sel1-like repeats; Region: SEL1; smart00671 936157001206 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936157001207 Sel1 repeat; Region: Sel1; pfam08238 936157001208 Sel1-like repeats; Region: SEL1; smart00671 936157001209 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936157001210 Sel1-like repeats; Region: SEL1; smart00671 936157001211 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936157001212 Sel1-like repeats; Region: SEL1; smart00671 936157001213 Sel1-like repeats; Region: SEL1; smart00671 936157001214 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 936157001215 UbiA prenyltransferase family; Region: UbiA; pfam01040 936157001216 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 936157001217 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 936157001218 Subunit I/III interface [polypeptide binding]; other site 936157001219 Subunit III/IV interface [polypeptide binding]; other site 936157001220 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 936157001221 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 936157001222 D-pathway; other site 936157001223 Putative ubiquinol binding site [chemical binding]; other site 936157001224 Low-spin heme (heme b) binding site [chemical binding]; other site 936157001225 Putative water exit pathway; other site 936157001226 Binuclear center (heme o3/CuB) [ion binding]; other site 936157001227 K-pathway; other site 936157001228 Putative proton exit pathway; other site 936157001229 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 936157001230 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 936157001231 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 936157001232 muropeptide transporter; Reviewed; Region: ampG; PRK11902 936157001233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157001234 putative substrate translocation pore; other site 936157001235 hypothetical protein; Provisional; Region: PRK11627 936157001236 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 936157001237 transcriptional regulator BolA; Provisional; Region: PRK11628 936157001238 trigger factor; Provisional; Region: tig; PRK01490 936157001239 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 936157001240 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 936157001241 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 936157001242 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 936157001243 oligomer interface [polypeptide binding]; other site 936157001244 active site residues [active] 936157001245 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 936157001246 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 936157001247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157001248 Walker A motif; other site 936157001249 ATP binding site [chemical binding]; other site 936157001250 Walker B motif; other site 936157001251 Iron permease FTR1 family; Region: FTR1; cl00475 936157001252 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 936157001253 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 936157001254 Found in ATP-dependent protease La (LON); Region: LON; smart00464 936157001255 Found in ATP-dependent protease La (LON); Region: LON; smart00464 936157001256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157001257 Walker A motif; other site 936157001258 ATP binding site [chemical binding]; other site 936157001259 Walker B motif; other site 936157001260 arginine finger; other site 936157001261 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 936157001262 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 936157001263 IHF dimer interface [polypeptide binding]; other site 936157001264 IHF - DNA interface [nucleotide binding]; other site 936157001265 periplasmic folding chaperone; Provisional; Region: PRK10788 936157001266 SurA N-terminal domain; Region: SurA_N_3; cl07813 936157001267 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 936157001268 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 936157001269 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 936157001270 active site 936157001271 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 936157001272 Ligand Binding Site [chemical binding]; other site 936157001273 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 936157001274 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 936157001275 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 936157001276 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 936157001277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157001278 active site 936157001279 motif I; other site 936157001280 motif II; other site 936157001281 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 936157001282 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 936157001283 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936157001284 catalytic residue [active] 936157001285 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 936157001286 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936157001287 putative DNA binding site [nucleotide binding]; other site 936157001288 putative Zn2+ binding site [ion binding]; other site 936157001289 AsnC family; Region: AsnC_trans_reg; pfam01037 936157001290 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 936157001291 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936157001292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157001293 Walker A/P-loop; other site 936157001294 ATP binding site [chemical binding]; other site 936157001295 Q-loop/lid; other site 936157001296 ABC transporter signature motif; other site 936157001297 Walker B; other site 936157001298 D-loop; other site 936157001299 H-loop/switch region; other site 936157001300 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 936157001301 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936157001302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157001303 Walker A/P-loop; other site 936157001304 ATP binding site [chemical binding]; other site 936157001305 Q-loop/lid; other site 936157001306 ABC transporter signature motif; other site 936157001307 Walker B; other site 936157001308 D-loop; other site 936157001309 H-loop/switch region; other site 936157001310 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 936157001311 Nitrogen regulatory protein P-II; Region: P-II; smart00938 936157001312 ammonium transporter; Provisional; Region: PRK10666 936157001313 acyl-CoA thioesterase II; Provisional; Region: PRK10526 936157001314 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 936157001315 active site 936157001316 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 936157001317 catalytic triad [active] 936157001318 dimer interface [polypeptide binding]; other site 936157001319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 936157001320 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 936157001321 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 936157001322 DNA binding site [nucleotide binding] 936157001323 active site 936157001324 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 936157001325 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 936157001326 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157001327 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 936157001328 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 936157001329 maltose O-acetyltransferase; Provisional; Region: PRK10092 936157001330 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 936157001331 active site 936157001332 substrate binding site [chemical binding]; other site 936157001333 trimer interface [polypeptide binding]; other site 936157001334 CoA binding site [chemical binding]; other site 936157001335 gene expression modulator; Provisional; Region: PRK10945 936157001336 Hha toxicity attenuator; Provisional; Region: PRK10667 936157001337 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 936157001338 Protein export membrane protein; Region: SecD_SecF; cl14618 936157001339 Protein export membrane protein; Region: SecD_SecF; cl14618 936157001340 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 936157001341 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157001342 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 936157001343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157001344 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 936157001345 hypothetical protein; Provisional; Region: PRK11281 936157001346 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 936157001347 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 936157001348 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936157001349 Uncharacterized conserved protein [Function unknown]; Region: COG5464 936157001350 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 936157001351 hypothetical protein; Provisional; Region: PRK11038 936157001352 primosomal replication protein N''; Provisional; Region: PRK10093 936157001353 hypothetical protein; Provisional; Region: PRK10527 936157001354 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936157001355 active site 936157001356 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 936157001357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157001358 Walker A motif; other site 936157001359 ATP binding site [chemical binding]; other site 936157001360 Walker B motif; other site 936157001361 DNA polymerase III subunit delta'; Validated; Region: PRK08485 936157001362 arginine finger; other site 936157001363 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 936157001364 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 936157001365 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 936157001366 hypothetical protein; Validated; Region: PRK00153 936157001367 recombination protein RecR; Reviewed; Region: recR; PRK00076 936157001368 RecR protein; Region: RecR; pfam02132 936157001369 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 936157001370 putative active site [active] 936157001371 putative metal-binding site [ion binding]; other site 936157001372 tetramer interface [polypeptide binding]; other site 936157001373 heat shock protein 90; Provisional; Region: PRK05218 936157001374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157001375 ATP binding site [chemical binding]; other site 936157001376 Mg2+ binding site [ion binding]; other site 936157001377 G-X-G motif; other site 936157001378 adenylate kinase; Reviewed; Region: adk; PRK00279 936157001379 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 936157001380 AMP-binding site [chemical binding]; other site 936157001381 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 936157001382 ferrochelatase; Reviewed; Region: hemH; PRK00035 936157001383 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 936157001384 C-terminal domain interface [polypeptide binding]; other site 936157001385 active site 936157001386 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 936157001387 active site 936157001388 N-terminal domain interface [polypeptide binding]; other site 936157001389 acetyl esterase; Provisional; Region: PRK10162 936157001390 inosine/guanosine kinase; Provisional; Region: PRK15074 936157001391 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936157001392 putative cation:proton antiport protein; Provisional; Region: PRK10669 936157001393 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 936157001394 TrkA-N domain; Region: TrkA_N; pfam02254 936157001395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157001396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936157001397 putative substrate translocation pore; other site 936157001398 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 936157001399 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 936157001400 active site 936157001401 metal binding site [ion binding]; metal-binding site 936157001402 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 936157001403 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 936157001404 putative deacylase active site [active] 936157001405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 936157001406 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 936157001407 copper exporting ATPase; Provisional; Region: copA; PRK10671 936157001408 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 936157001409 metal-binding site [ion binding] 936157001410 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 936157001411 metal-binding site [ion binding] 936157001412 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936157001413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157001414 motif II; other site 936157001415 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 936157001416 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 936157001417 DNA binding residues [nucleotide binding] 936157001418 dimer interface [polypeptide binding]; other site 936157001419 copper binding site [ion binding]; other site 936157001420 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 936157001421 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 936157001422 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 936157001423 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 936157001424 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 936157001425 Walker A/P-loop; other site 936157001426 ATP binding site [chemical binding]; other site 936157001427 Q-loop/lid; other site 936157001428 ABC transporter signature motif; other site 936157001429 Walker B; other site 936157001430 D-loop; other site 936157001431 H-loop/switch region; other site 936157001432 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 936157001433 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 936157001434 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 936157001435 oxidoreductase; Provisional; Region: PRK08017 936157001436 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 936157001437 NADP binding site [chemical binding]; other site 936157001438 active site 936157001439 steroid binding site; other site 936157001440 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 936157001441 active site 936157001442 catalytic triad [active] 936157001443 oxyanion hole [active] 936157001444 switch loop; other site 936157001445 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 936157001446 FtsX-like permease family; Region: FtsX; pfam02687 936157001447 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 936157001448 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 936157001449 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 936157001450 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 936157001451 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 936157001452 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 936157001453 Walker A/P-loop; other site 936157001454 ATP binding site [chemical binding]; other site 936157001455 Q-loop/lid; other site 936157001456 ABC transporter signature motif; other site 936157001457 Walker B; other site 936157001458 D-loop; other site 936157001459 H-loop/switch region; other site 936157001460 NIL domain; Region: NIL; pfam09383 936157001461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157001462 dimer interface [polypeptide binding]; other site 936157001463 conserved gate region; other site 936157001464 ABC-ATPase subunit interface; other site 936157001465 Predicted ATPase [General function prediction only]; Region: COG2603 936157001466 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 936157001467 active site residue [active] 936157001468 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 936157001469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157001470 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 936157001471 dimerization interface [polypeptide binding]; other site 936157001472 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 936157001473 ureidoglycolate hydrolase; Provisional; Region: PRK03606 936157001474 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 936157001475 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 936157001476 Bacterial transcriptional regulator; Region: IclR; pfam01614 936157001477 glyoxylate carboligase; Provisional; Region: PRK11269 936157001478 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 936157001479 PYR/PP interface [polypeptide binding]; other site 936157001480 dimer interface [polypeptide binding]; other site 936157001481 TPP binding site [chemical binding]; other site 936157001482 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 936157001483 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 936157001484 TPP-binding site [chemical binding]; other site 936157001485 hydroxypyruvate isomerase; Provisional; Region: PRK09997 936157001486 tartronate semialdehyde reductase; Provisional; Region: PRK15059 936157001487 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 936157001488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157001489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936157001490 putative substrate translocation pore; other site 936157001491 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 936157001492 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 936157001493 Na binding site [ion binding]; other site 936157001494 putative substrate binding site [chemical binding]; other site 936157001495 allantoinase; Provisional; Region: PRK08044 936157001496 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 936157001497 active site 936157001498 putative uracil/xanthine transporter; Provisional; Region: PRK11412 936157001499 glycerate kinase II; Provisional; Region: PRK09932 936157001500 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 936157001501 Cupin domain; Region: Cupin_2; pfam07883 936157001502 allantoate amidohydrolase; Region: AllC; TIGR03176 936157001503 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 936157001504 active site 936157001505 metal binding site [ion binding]; metal-binding site 936157001506 dimer interface [polypeptide binding]; other site 936157001507 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 936157001508 membrane protein FdrA; Validated; Region: PRK06091 936157001509 CoA binding domain; Region: CoA_binding; pfam02629 936157001510 CoA-ligase; Region: Ligase_CoA; pfam00549 936157001511 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 936157001512 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 936157001513 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 936157001514 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 936157001515 putative substrate binding site [chemical binding]; other site 936157001516 nucleotide binding site [chemical binding]; other site 936157001517 nucleotide binding site [chemical binding]; other site 936157001518 homodimer interface [polypeptide binding]; other site 936157001519 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 936157001520 ATP-grasp domain; Region: ATP-grasp; pfam02222 936157001521 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 936157001522 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 936157001523 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 936157001524 putative active site [active] 936157001525 putative metal binding site [ion binding]; other site 936157001526 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 936157001527 substrate binding site [chemical binding]; other site 936157001528 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 936157001529 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 936157001530 active site 936157001531 HIGH motif; other site 936157001532 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 936157001533 KMSKS motif; other site 936157001534 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 936157001535 tRNA binding surface [nucleotide binding]; other site 936157001536 anticodon binding site; other site 936157001537 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 936157001538 ribosome-associated protein; Provisional; Region: PRK11507 936157001539 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 936157001540 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 936157001541 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 936157001542 homodimer interface [polypeptide binding]; other site 936157001543 NADP binding site [chemical binding]; other site 936157001544 substrate binding site [chemical binding]; other site 936157001545 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 936157001546 fimbrial protein FimI; Provisional; Region: PRK15200 936157001547 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 936157001548 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 936157001549 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 936157001550 outer membrane usher protein FimD; Provisional; Region: PRK15198 936157001551 PapC N-terminal domain; Region: PapC_N; pfam13954 936157001552 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 936157001553 PapC C-terminal domain; Region: PapC_C; pfam13953 936157001554 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 936157001555 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 936157001556 transcriptional regulator FimZ; Provisional; Region: PRK09935 936157001557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157001558 active site 936157001559 phosphorylation site [posttranslational modification] 936157001560 intermolecular recognition site; other site 936157001561 dimerization interface [polypeptide binding]; other site 936157001562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157001563 DNA binding residues [nucleotide binding] 936157001564 dimerization interface [polypeptide binding]; other site 936157001565 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 936157001566 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157001567 DNA binding residues [nucleotide binding] 936157001568 dimerization interface [polypeptide binding]; other site 936157001569 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 936157001570 Cupin; Region: Cupin_6; pfam12852 936157001571 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 936157001572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157001573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157001574 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 936157001575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936157001576 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 936157001577 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 936157001578 Predicted membrane protein [Function unknown]; Region: COG3059 936157001579 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 936157001580 phenylalanine transporter; Provisional; Region: PRK10249 936157001581 Spore germination protein; Region: Spore_permease; cl17796 936157001582 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 936157001583 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936157001584 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 936157001585 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 936157001586 active site 936157001587 oxyanion hole [active] 936157001588 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 936157001589 catalytic triad [active] 936157001590 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 936157001591 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 936157001592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157001593 ATP binding site [chemical binding]; other site 936157001594 Walker B motif; other site 936157001595 arginine finger; other site 936157001596 Transcriptional antiterminator [Transcription]; Region: COG3933 936157001597 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 936157001598 active pocket/dimerization site; other site 936157001599 active site 936157001600 phosphorylation site [posttranslational modification] 936157001601 PRD domain; Region: PRD; pfam00874 936157001602 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 936157001603 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 936157001604 putative active site [active] 936157001605 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 936157001606 dimer interface [polypeptide binding]; other site 936157001607 active site 936157001608 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 936157001609 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 936157001610 dimer interface [polypeptide binding]; other site 936157001611 active site 936157001612 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 936157001613 dimer interface [polypeptide binding]; other site 936157001614 active site 936157001615 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 936157001616 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 936157001617 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 936157001618 active site 936157001619 phosphorylation site [posttranslational modification] 936157001620 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 936157001621 active pocket/dimerization site; other site 936157001622 active site 936157001623 phosphorylation site [posttranslational modification] 936157001624 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 936157001625 dimer interface [polypeptide binding]; other site 936157001626 FMN binding site [chemical binding]; other site 936157001627 hypothetical protein; Provisional; Region: PRK10250 936157001628 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936157001629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157001630 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 936157001631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157001632 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 936157001633 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 936157001634 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 936157001635 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 936157001636 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 936157001637 outer membrane receptor FepA; Provisional; Region: PRK13524 936157001638 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 936157001639 N-terminal plug; other site 936157001640 ligand-binding site [chemical binding]; other site 936157001641 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 936157001642 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 936157001643 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 936157001644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 936157001645 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 936157001646 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936157001647 acyl-activating enzyme (AAE) consensus motif; other site 936157001648 AMP binding site [chemical binding]; other site 936157001649 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936157001650 LPS O-antigen length regulator; Provisional; Region: PRK10381 936157001651 Chain length determinant protein; Region: Wzz; pfam02706 936157001652 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 936157001653 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 936157001654 Walker A/P-loop; other site 936157001655 ATP binding site [chemical binding]; other site 936157001656 Q-loop/lid; other site 936157001657 ABC transporter signature motif; other site 936157001658 Walker B; other site 936157001659 D-loop; other site 936157001660 H-loop/switch region; other site 936157001661 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 936157001662 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936157001663 ABC-ATPase subunit interface; other site 936157001664 dimer interface [polypeptide binding]; other site 936157001665 putative PBP binding regions; other site 936157001666 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 936157001667 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936157001668 ABC-ATPase subunit interface; other site 936157001669 dimer interface [polypeptide binding]; other site 936157001670 putative PBP binding regions; other site 936157001671 enterobactin exporter EntS; Provisional; Region: PRK10489 936157001672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157001673 putative substrate translocation pore; other site 936157001674 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 936157001675 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 936157001676 siderophore binding site; other site 936157001677 isochorismate synthase EntC; Provisional; Region: PRK15016 936157001678 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 936157001679 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 936157001680 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 936157001681 acyl-activating enzyme (AAE) consensus motif; other site 936157001682 active site 936157001683 AMP binding site [chemical binding]; other site 936157001684 substrate binding site [chemical binding]; other site 936157001685 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 936157001686 hydrophobic substrate binding pocket; other site 936157001687 Isochorismatase family; Region: Isochorismatase; pfam00857 936157001688 active site 936157001689 conserved cis-peptide bond; other site 936157001690 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 936157001691 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 936157001692 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 936157001693 putative NAD(P) binding site [chemical binding]; other site 936157001694 active site 936157001695 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 936157001696 CoenzymeA binding site [chemical binding]; other site 936157001697 subunit interaction site [polypeptide binding]; other site 936157001698 PHB binding site; other site 936157001699 carbon starvation protein A; Provisional; Region: PRK15015 936157001700 Carbon starvation protein CstA; Region: CstA; pfam02554 936157001701 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 936157001702 Uncharacterized small protein [Function unknown]; Region: COG2879 936157001703 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 936157001704 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 936157001705 putative active site [active] 936157001706 metal binding site [ion binding]; metal-binding site 936157001707 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 936157001708 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936157001709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157001710 homodimer interface [polypeptide binding]; other site 936157001711 catalytic residue [active] 936157001712 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 936157001713 ParB-like nuclease domain; Region: ParBc; pfam02195 936157001714 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 936157001715 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 936157001716 Active Sites [active] 936157001717 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 936157001718 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 936157001719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157001720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 936157001721 dimerization interface [polypeptide binding]; other site 936157001722 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 936157001723 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 936157001724 dimerization domain [polypeptide binding]; other site 936157001725 dimer interface [polypeptide binding]; other site 936157001726 catalytic residues [active] 936157001727 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 936157001728 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 936157001729 dimer interface [polypeptide binding]; other site 936157001730 decamer (pentamer of dimers) interface [polypeptide binding]; other site 936157001731 catalytic triad [active] 936157001732 peroxidatic and resolving cysteines [active] 936157001733 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 936157001734 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 936157001735 catalytic residue [active] 936157001736 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 936157001737 catalytic residues [active] 936157001738 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936157001739 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936157001740 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 936157001741 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 936157001742 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 936157001743 putative [4Fe-4S] binding site [ion binding]; other site 936157001744 putative molybdopterin cofactor binding site [chemical binding]; other site 936157001745 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 936157001746 molybdopterin cofactor binding site; other site 936157001747 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 936157001748 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 936157001749 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 936157001750 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 936157001751 Ligand Binding Site [chemical binding]; other site 936157001752 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 936157001753 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 936157001754 NAD binding site [chemical binding]; other site 936157001755 catalytic Zn binding site [ion binding]; other site 936157001756 structural Zn binding site [ion binding]; other site 936157001757 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 936157001758 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 936157001759 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 936157001760 B1 nucleotide binding pocket [chemical binding]; other site 936157001761 B2 nucleotide binding pocket [chemical binding]; other site 936157001762 CAS motifs; other site 936157001763 active site 936157001764 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 936157001765 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 936157001766 transmembrane helices; other site 936157001767 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 936157001768 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 936157001769 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 936157001770 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 936157001771 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 936157001772 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 936157001773 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 936157001774 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 936157001775 putative active site [active] 936157001776 (T/H)XGH motif; other site 936157001777 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 936157001778 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936157001779 putative active site [active] 936157001780 heme pocket [chemical binding]; other site 936157001781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157001782 ATP binding site [chemical binding]; other site 936157001783 Mg2+ binding site [ion binding]; other site 936157001784 G-X-G motif; other site 936157001785 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 936157001786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157001787 active site 936157001788 phosphorylation site [posttranslational modification] 936157001789 intermolecular recognition site; other site 936157001790 dimerization interface [polypeptide binding]; other site 936157001791 Transcriptional regulator; Region: CitT; pfam12431 936157001792 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 936157001793 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 936157001794 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 936157001795 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 936157001796 DNA-binding site [nucleotide binding]; DNA binding site 936157001797 RNA-binding motif; other site 936157001798 chromosome condensation membrane protein; Provisional; Region: PRK14196 936157001799 Predicted amidohydrolase [General function prediction only]; Region: COG0388 936157001800 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 936157001801 putative active site [active] 936157001802 catalytic triad [active] 936157001803 putative dimer interface [polypeptide binding]; other site 936157001804 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 936157001805 lipoyl synthase; Provisional; Region: PRK05481 936157001806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157001807 FeS/SAM binding site; other site 936157001808 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 936157001809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157001810 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 936157001811 substrate binding pocket [chemical binding]; other site 936157001812 dimerization interface [polypeptide binding]; other site 936157001813 lipoate-protein ligase B; Provisional; Region: PRK14342 936157001814 hypothetical protein; Provisional; Region: PRK04998 936157001815 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 936157001816 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 936157001817 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 936157001818 rare lipoprotein A; Provisional; Region: PRK10672 936157001819 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 936157001820 Sporulation related domain; Region: SPOR; pfam05036 936157001821 cell wall shape-determining protein; Provisional; Region: PRK10794 936157001822 penicillin-binding protein 2; Provisional; Region: PRK10795 936157001823 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936157001824 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936157001825 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 936157001826 ribosome-associated protein; Provisional; Region: PRK11538 936157001827 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 936157001828 catalytic core [active] 936157001829 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 936157001830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936157001831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157001832 homodimer interface [polypeptide binding]; other site 936157001833 catalytic residue [active] 936157001834 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 936157001835 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 936157001836 active site 936157001837 (T/H)XGH motif; other site 936157001838 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 936157001839 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 936157001840 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 936157001841 HIGH motif; other site 936157001842 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 936157001843 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 936157001844 active site 936157001845 KMSKS motif; other site 936157001846 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 936157001847 tRNA binding surface [nucleotide binding]; other site 936157001848 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 936157001849 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 936157001850 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 936157001851 Propionate catabolism activator; Region: PrpR_N; pfam06506 936157001852 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 936157001853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157001854 Walker A motif; other site 936157001855 ATP binding site [chemical binding]; other site 936157001856 Walker B motif; other site 936157001857 arginine finger; other site 936157001858 hypothetical protein; Provisional; Region: PRK11032 936157001859 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 936157001860 Uncharacterized protein ybeQ;, Sel1 repeat, Tetratricopeptide-like helical 936157001861 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 936157001862 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 936157001863 HSP70 interaction site [polypeptide binding]; other site 936157001864 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 936157001865 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 936157001866 HSP70 interaction site [polypeptide binding]; other site 936157001867 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 936157001868 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 936157001869 nucleotide binding site [chemical binding]; other site 936157001870 putative NEF/HSP70 interaction site [polypeptide binding]; other site 936157001871 SBD interface [polypeptide binding]; other site 936157001872 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 936157001873 active site 936157001874 tetramer interface [polypeptide binding]; other site 936157001875 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 936157001876 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 936157001877 Walker A/P-loop; other site 936157001878 ATP binding site [chemical binding]; other site 936157001879 Q-loop/lid; other site 936157001880 ABC transporter signature motif; other site 936157001881 Walker B; other site 936157001882 D-loop; other site 936157001883 H-loop/switch region; other site 936157001884 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 936157001885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157001886 dimer interface [polypeptide binding]; other site 936157001887 conserved gate region; other site 936157001888 putative PBP binding loops; other site 936157001889 ABC-ATPase subunit interface; other site 936157001890 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 936157001891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157001892 dimer interface [polypeptide binding]; other site 936157001893 conserved gate region; other site 936157001894 putative PBP binding loops; other site 936157001895 ABC-ATPase subunit interface; other site 936157001896 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 936157001897 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157001898 substrate binding pocket [chemical binding]; other site 936157001899 membrane-bound complex binding site; other site 936157001900 hinge residues; other site 936157001901 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 936157001902 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 936157001903 putative active site [active] 936157001904 catalytic triad [active] 936157001905 putative dimer interface [polypeptide binding]; other site 936157001906 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 936157001907 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 936157001908 Transporter associated domain; Region: CorC_HlyC; smart01091 936157001909 metal-binding heat shock protein; Provisional; Region: PRK00016 936157001910 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 936157001911 PhoH-like protein; Region: PhoH; pfam02562 936157001912 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 936157001913 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 936157001914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157001915 FeS/SAM binding site; other site 936157001916 TRAM domain; Region: TRAM; pfam01938 936157001917 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 936157001918 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 936157001919 asparagine synthetase B; Provisional; Region: asnB; PRK09431 936157001920 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 936157001921 active site 936157001922 dimer interface [polypeptide binding]; other site 936157001923 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 936157001924 Ligand Binding Site [chemical binding]; other site 936157001925 Molecular Tunnel; other site 936157001926 UMP phosphatase; Provisional; Region: PRK10444 936157001927 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 936157001928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157001929 MarR family; Region: MarR; pfam01047 936157001930 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 936157001931 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936157001932 nucleotide binding site [chemical binding]; other site 936157001933 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 936157001934 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 936157001935 active site 936157001936 dimer interface [polypeptide binding]; other site 936157001937 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 936157001938 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 936157001939 active site 936157001940 trimer interface [polypeptide binding]; other site 936157001941 allosteric site; other site 936157001942 active site lid [active] 936157001943 hexamer (dimer of trimers) interface [polypeptide binding]; other site 936157001944 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 936157001945 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936157001946 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936157001947 active site turn [active] 936157001948 phosphorylation site [posttranslational modification] 936157001949 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 936157001950 HPr interaction site; other site 936157001951 glycerol kinase (GK) interaction site [polypeptide binding]; other site 936157001952 active site 936157001953 phosphorylation site [posttranslational modification] 936157001954 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 936157001955 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 936157001956 active site 936157001957 HIGH motif; other site 936157001958 nucleotide binding site [chemical binding]; other site 936157001959 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 936157001960 KMSKS motif; other site 936157001961 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 936157001962 outer membrane porin, OprD family; Region: OprD; pfam03573 936157001963 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 936157001964 YbfN-like lipoprotein; Region: YbfN; pfam13982 936157001965 citrate-proton symporter; Provisional; Region: PRK15075 936157001966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157001967 putative substrate translocation pore; other site 936157001968 tricarballylate utilization protein B; Provisional; Region: PRK15033 936157001969 tricarballylate dehydrogenase; Validated; Region: PRK08274 936157001970 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936157001971 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157001972 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157001973 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 936157001974 putative dimerization interface [polypeptide binding]; other site 936157001975 ferric uptake regulator; Provisional; Region: fur; PRK09462 936157001976 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 936157001977 metal binding site 2 [ion binding]; metal-binding site 936157001978 putative DNA binding helix; other site 936157001979 metal binding site 1 [ion binding]; metal-binding site 936157001980 dimer interface [polypeptide binding]; other site 936157001981 structural Zn2+ binding site [ion binding]; other site 936157001982 flavodoxin FldA; Validated; Region: PRK09267 936157001983 LexA regulated protein; Provisional; Region: PRK11675 936157001984 acyl-CoA esterase; Provisional; Region: PRK10673 936157001985 PGAP1-like protein; Region: PGAP1; pfam07819 936157001986 replication initiation regulator SeqA; Provisional; Region: PRK11187 936157001987 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 936157001988 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 936157001989 active site 936157001990 substrate binding site [chemical binding]; other site 936157001991 metal binding site [ion binding]; metal-binding site 936157001992 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 936157001993 putrescine transporter; Provisional; Region: potE; PRK10655 936157001994 ornithine decarboxylase; Provisional; Region: PRK13578 936157001995 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 936157001996 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 936157001997 homodimer interface [polypeptide binding]; other site 936157001998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157001999 catalytic residue [active] 936157002000 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 936157002001 Protein of unknown function (DUF2618); Region: DUF2618; pfam10940 936157002002 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 936157002003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157002004 active site 936157002005 phosphorylation site [posttranslational modification] 936157002006 intermolecular recognition site; other site 936157002007 dimerization interface [polypeptide binding]; other site 936157002008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157002009 DNA binding site [nucleotide binding] 936157002010 sensor protein KdpD; Provisional; Region: PRK10490 936157002011 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 936157002012 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 936157002013 Ligand Binding Site [chemical binding]; other site 936157002014 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 936157002015 GAF domain; Region: GAF_3; pfam13492 936157002016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157002017 dimer interface [polypeptide binding]; other site 936157002018 phosphorylation site [posttranslational modification] 936157002019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157002020 ATP binding site [chemical binding]; other site 936157002021 Mg2+ binding site [ion binding]; other site 936157002022 G-X-G motif; other site 936157002023 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 936157002024 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 936157002025 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936157002026 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 936157002027 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 936157002028 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 936157002029 DNA photolyase; Region: DNA_photolyase; pfam00875 936157002030 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 936157002031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157002032 putative substrate translocation pore; other site 936157002033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157002034 Uncharacterized conserved protein [Function unknown]; Region: COG0327 936157002035 metal-binding protein; Provisional; Region: PRK10799 936157002036 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 936157002037 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 936157002038 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 936157002039 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 936157002040 putative active site [active] 936157002041 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 936157002042 active site 936157002043 DNA binding site [nucleotide binding] 936157002044 Int/Topo IB signature motif; other site 936157002045 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 936157002046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 936157002047 UDP-galactopyranose mutase; Region: GLF; pfam03275 936157002048 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 936157002049 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 936157002050 active site 936157002051 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 936157002052 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936157002053 putative ADP-binding pocket [chemical binding]; other site 936157002054 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 936157002055 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 936157002056 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 936157002057 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 936157002058 Walker A/P-loop; other site 936157002059 ATP binding site [chemical binding]; other site 936157002060 Q-loop/lid; other site 936157002061 ABC transporter signature motif; other site 936157002062 Walker B; other site 936157002063 D-loop; other site 936157002064 H-loop/switch region; other site 936157002065 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 936157002066 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 936157002067 active site 936157002068 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 936157002069 active site 936157002070 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 936157002071 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 936157002072 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 936157002073 endonuclease VIII; Provisional; Region: PRK10445 936157002074 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 936157002075 DNA binding site [nucleotide binding] 936157002076 catalytic residue [active] 936157002077 putative catalytic residues [active] 936157002078 H2TH interface [polypeptide binding]; other site 936157002079 intercalation triad [nucleotide binding]; other site 936157002080 substrate specificity determining residue; other site 936157002081 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 936157002082 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 936157002083 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 936157002084 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 936157002085 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 936157002086 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 936157002087 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 936157002088 dimer interface [polypeptide binding]; other site 936157002089 active site 936157002090 citrylCoA binding site [chemical binding]; other site 936157002091 NADH binding [chemical binding]; other site 936157002092 cationic pore residues; other site 936157002093 oxalacetate/citrate binding site [chemical binding]; other site 936157002094 coenzyme A binding site [chemical binding]; other site 936157002095 catalytic triad [active] 936157002096 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 936157002097 Iron-sulfur protein interface; other site 936157002098 proximal quinone binding site [chemical binding]; other site 936157002099 SdhD (CybS) interface [polypeptide binding]; other site 936157002100 proximal heme binding site [chemical binding]; other site 936157002101 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 936157002102 SdhC subunit interface [polypeptide binding]; other site 936157002103 proximal heme binding site [chemical binding]; other site 936157002104 cardiolipin binding site; other site 936157002105 Iron-sulfur protein interface; other site 936157002106 proximal quinone binding site [chemical binding]; other site 936157002107 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 936157002108 L-aspartate oxidase; Provisional; Region: PRK06175 936157002109 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 936157002110 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 936157002111 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 936157002112 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 936157002113 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 936157002114 TPP-binding site [chemical binding]; other site 936157002115 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 936157002116 dimer interface [polypeptide binding]; other site 936157002117 PYR/PP interface [polypeptide binding]; other site 936157002118 TPP binding site [chemical binding]; other site 936157002119 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 936157002120 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 936157002121 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 936157002122 E3 interaction surface; other site 936157002123 lipoyl attachment site [posttranslational modification]; other site 936157002124 e3 binding domain; Region: E3_binding; pfam02817 936157002125 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 936157002126 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 936157002127 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 936157002128 CoA-ligase; Region: Ligase_CoA; pfam00549 936157002129 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 936157002130 CoA binding domain; Region: CoA_binding; smart00881 936157002131 CoA-ligase; Region: Ligase_CoA; pfam00549 936157002132 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 936157002133 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 936157002134 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 936157002135 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 936157002136 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 936157002137 hypothetical protein; Provisional; Region: PRK10588 936157002138 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 936157002139 active site 936157002140 colicin uptake protein TolQ; Provisional; Region: PRK10801 936157002141 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 936157002142 colicin uptake protein TolR; Provisional; Region: PRK11024 936157002143 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 936157002144 TolA C-terminal; Region: TolA; pfam06519 936157002145 translocation protein TolB; Provisional; Region: tolB; PRK03629 936157002146 TolB amino-terminal domain; Region: TolB_N; pfam04052 936157002147 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 936157002148 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 936157002149 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 936157002150 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 936157002151 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 936157002152 ligand binding site [chemical binding]; other site 936157002153 tol-pal system protein YbgF; Provisional; Region: PRK10803 936157002154 Tetratricopeptide repeat; Region: TPR_6; pfam13174 936157002155 Tetratricopeptide repeat; Region: TPR_6; pfam13174 936157002156 quinolinate synthetase; Provisional; Region: PRK09375 936157002157 zinc transporter ZitB; Provisional; Region: PRK03557 936157002158 YbgS-like protein; Region: YbgS; pfam13985 936157002159 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 936157002160 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 936157002161 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 936157002162 fumarate hydratase; Provisional; Region: PRK06246 936157002163 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157002164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157002165 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936157002166 dimerization interface [polypeptide binding]; other site 936157002167 cell density-dependent motility repressor; Provisional; Region: PRK10082 936157002168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157002169 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936157002170 dimerization interface [polypeptide binding]; other site 936157002171 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 936157002172 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 936157002173 transmembrane helices; other site 936157002174 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 936157002175 Pyruvate carboxylase subunit B; Pyruvic carboxylase B;, HMGL-like, oadA: oxaloacetate decarboxylase alpha subunit, Aldolase-type TIM barrel 936157002176 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 936157002177 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 936157002178 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 936157002179 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936157002180 dimer interface [polypeptide binding]; other site 936157002181 putative PBP binding regions; other site 936157002182 ABC-ATPase subunit interface; other site 936157002183 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 936157002184 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 936157002185 Walker A/P-loop; other site 936157002186 ATP binding site [chemical binding]; other site 936157002187 Q-loop/lid; other site 936157002188 ABC transporter signature motif; other site 936157002189 Walker B; other site 936157002190 D-loop; other site 936157002191 H-loop/switch region; other site 936157002192 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 936157002193 catalytic core [active] 936157002194 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 936157002195 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 936157002196 active site 936157002197 catalytic residues [active] 936157002198 galactokinase; Provisional; Region: PRK05101 936157002199 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 936157002200 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 936157002201 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 936157002202 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 936157002203 dimer interface [polypeptide binding]; other site 936157002204 active site 936157002205 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 936157002206 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 936157002207 NAD binding site [chemical binding]; other site 936157002208 homodimer interface [polypeptide binding]; other site 936157002209 active site 936157002210 substrate binding site [chemical binding]; other site 936157002211 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 936157002212 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 936157002213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157002214 Walker A/P-loop; other site 936157002215 ATP binding site [chemical binding]; other site 936157002216 Q-loop/lid; other site 936157002217 ABC transporter signature motif; other site 936157002218 Walker B; other site 936157002219 D-loop; other site 936157002220 H-loop/switch region; other site 936157002221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157002222 Walker A/P-loop; other site 936157002223 ATP binding site [chemical binding]; other site 936157002224 Q-loop/lid; other site 936157002225 ABC transporter signature motif; other site 936157002226 Walker B; other site 936157002227 D-loop; other site 936157002228 H-loop/switch region; other site 936157002229 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 936157002230 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 936157002231 molybdenum-pterin binding domain; Region: Mop; TIGR00638 936157002232 TOBE domain; Region: TOBE; pfam03459 936157002233 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 936157002234 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 936157002235 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157002236 substrate binding pocket [chemical binding]; other site 936157002237 membrane-bound complex binding site; other site 936157002238 hinge residues; other site 936157002239 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 936157002240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157002241 dimer interface [polypeptide binding]; other site 936157002242 conserved gate region; other site 936157002243 putative PBP binding loops; other site 936157002244 ABC-ATPase subunit interface; other site 936157002245 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 936157002246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157002247 Walker A/P-loop; other site 936157002248 ATP binding site [chemical binding]; other site 936157002249 Q-loop/lid; other site 936157002250 ABC transporter signature motif; other site 936157002251 Walker B; other site 936157002252 D-loop; other site 936157002253 H-loop/switch region; other site 936157002254 molybdenum-pterin binding domain; Region: Mop; TIGR00638 936157002255 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 936157002256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157002257 active site 936157002258 motif I; other site 936157002259 motif II; other site 936157002260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157002261 6-phosphogluconolactonase; Provisional; Region: PRK11028 936157002262 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157002263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157002264 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 936157002265 putative dimerization interface [polypeptide binding]; other site 936157002266 PrpF protein; Region: PrpF; pfam04303 936157002267 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 936157002268 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 936157002269 transmembrane helices; other site 936157002270 putative hydratase; Provisional; Region: PRK11413 936157002271 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 936157002272 substrate binding site [chemical binding]; other site 936157002273 ligand binding site [chemical binding]; other site 936157002274 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 936157002275 substrate binding site [chemical binding]; other site 936157002276 acyl-CoA thioesterase; Provisional; Region: PRK10531 936157002277 putative pectinesterase; Region: PLN02432; cl01911 936157002278 imidazolonepropionase; Validated; Region: PRK09356 936157002279 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 936157002280 active site 936157002281 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 936157002282 putative active site [active] 936157002283 putative metal binding site [ion binding]; other site 936157002284 histidine utilization repressor; Provisional; Region: PRK14999 936157002285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157002286 DNA-binding site [nucleotide binding]; DNA binding site 936157002287 UTRA domain; Region: UTRA; pfam07702 936157002288 urocanate hydratase; Provisional; Region: PRK05414 936157002289 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 936157002290 active sites [active] 936157002291 tetramer interface [polypeptide binding]; other site 936157002292 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 936157002293 substrate binding site [chemical binding]; other site 936157002294 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 936157002295 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936157002296 inhibitor-cofactor binding pocket; inhibition site 936157002297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157002298 catalytic residue [active] 936157002299 biotin synthase; Provisional; Region: PRK15108 936157002300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157002301 FeS/SAM binding site; other site 936157002302 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 936157002303 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 936157002304 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 936157002305 substrate-cofactor binding pocket; other site 936157002306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157002307 catalytic residue [active] 936157002308 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 936157002309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157002310 S-adenosylmethionine binding site [chemical binding]; other site 936157002311 AAA domain; Region: AAA_26; pfam13500 936157002312 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 936157002313 excinuclease ABC subunit B; Provisional; Region: PRK05298 936157002314 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936157002315 ATP binding site [chemical binding]; other site 936157002316 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157002317 nucleotide binding region [chemical binding]; other site 936157002318 ATP-binding site [chemical binding]; other site 936157002319 Ultra-violet resistance protein B; Region: UvrB; pfam12344 936157002320 UvrB/uvrC motif; Region: UVR; pfam02151 936157002321 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 936157002322 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 936157002323 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 936157002324 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 936157002325 Leucine-rich repeats; other site 936157002326 Substrate binding site [chemical binding]; other site 936157002327 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 936157002328 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 936157002329 putative substrate binding pocket [chemical binding]; other site 936157002330 dimer interface [polypeptide binding]; other site 936157002331 phosphate binding site [ion binding]; other site 936157002332 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 936157002333 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157002334 FeS/SAM binding site; other site 936157002335 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 936157002336 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 936157002337 MPT binding site; other site 936157002338 trimer interface [polypeptide binding]; other site 936157002339 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 936157002340 trimer interface [polypeptide binding]; other site 936157002341 dimer interface [polypeptide binding]; other site 936157002342 putative active site [active] 936157002343 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 936157002344 MoaE interaction surface [polypeptide binding]; other site 936157002345 MoeB interaction surface [polypeptide binding]; other site 936157002346 thiocarboxylated glycine; other site 936157002347 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 936157002348 MoaE homodimer interface [polypeptide binding]; other site 936157002349 MoaD interaction [polypeptide binding]; other site 936157002350 active site residues [active] 936157002351 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 936157002352 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 936157002353 Transposase IS200 like; Region: Y1_Tnp; pfam01797 936157002354 Transposase, Mutator family; Region: Transposase_mut; pfam00872 936157002355 MULE transposase domain; Region: MULE; pfam10551 936157002356 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 936157002357 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 936157002358 Predicted integral membrane protein [Function unknown]; Region: COG0392 936157002359 cardiolipin synthase 2; Provisional; Region: PRK11263 936157002360 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 936157002361 putative active site [active] 936157002362 catalytic site [active] 936157002363 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 936157002364 putative active site [active] 936157002365 catalytic site [active] 936157002366 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 936157002367 putative catalytic site [active] 936157002368 putative metal binding site [ion binding]; other site 936157002369 putative phosphate binding site [ion binding]; other site 936157002370 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 936157002371 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 936157002372 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 936157002373 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 936157002374 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 936157002375 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 936157002376 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936157002377 Walker A/P-loop; other site 936157002378 ATP binding site [chemical binding]; other site 936157002379 Q-loop/lid; other site 936157002380 ABC transporter signature motif; other site 936157002381 Walker B; other site 936157002382 D-loop; other site 936157002383 H-loop/switch region; other site 936157002384 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 936157002385 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936157002386 Walker A/P-loop; other site 936157002387 ATP binding site [chemical binding]; other site 936157002388 Q-loop/lid; other site 936157002389 ABC transporter signature motif; other site 936157002390 Walker B; other site 936157002391 D-loop; other site 936157002392 H-loop/switch region; other site 936157002393 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 936157002394 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936157002395 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157002396 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 936157002397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157002398 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 936157002399 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 936157002400 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 936157002401 ATP binding site [chemical binding]; other site 936157002402 Mg++ binding site [ion binding]; other site 936157002403 motif III; other site 936157002404 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157002405 nucleotide binding region [chemical binding]; other site 936157002406 ATP-binding site [chemical binding]; other site 936157002407 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 936157002408 DEAD_2; Region: DEAD_2; pfam06733 936157002409 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 936157002410 glycosyl transferase family protein; Provisional; Region: PRK08136 936157002411 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 936157002412 hypothetical protein; Provisional; Region: PRK10259 936157002413 hypothetical protein; Provisional; Region: PRK11019 936157002414 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 936157002415 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 936157002416 putative mechanosensitive channel protein; Provisional; Region: PRK11465 936157002417 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936157002418 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 936157002419 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 936157002420 Walker A/P-loop; other site 936157002421 ATP binding site [chemical binding]; other site 936157002422 Q-loop/lid; other site 936157002423 ABC transporter signature motif; other site 936157002424 Walker B; other site 936157002425 D-loop; other site 936157002426 H-loop/switch region; other site 936157002427 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 936157002428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157002429 dimer interface [polypeptide binding]; other site 936157002430 conserved gate region; other site 936157002431 putative PBP binding loops; other site 936157002432 ABC-ATPase subunit interface; other site 936157002433 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 936157002434 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157002435 substrate binding pocket [chemical binding]; other site 936157002436 membrane-bound complex binding site; other site 936157002437 hinge residues; other site 936157002438 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 936157002439 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 936157002440 dimerization interface [polypeptide binding]; other site 936157002441 DPS ferroxidase diiron center [ion binding]; other site 936157002442 ion pore; other site 936157002443 threonine and homoserine efflux system; Provisional; Region: PRK10532 936157002444 EamA-like transporter family; Region: EamA; pfam00892 936157002445 outer membrane protein X; Provisional; Region: ompX; PRK09408 936157002446 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 936157002447 Sulfatase; Region: Sulfatase; pfam00884 936157002448 manganese transport regulator MntR; Provisional; Region: PRK11050 936157002449 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 936157002450 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 936157002451 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 936157002452 transmembrane helices; other site 936157002453 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 936157002454 L,D-transpeptidase; Provisional; Region: PRK10260 936157002455 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 936157002456 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 936157002457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936157002458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157002459 Walker A/P-loop; other site 936157002460 ATP binding site [chemical binding]; other site 936157002461 ABC transporter signature motif; other site 936157002462 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936157002463 Walker B; other site 936157002464 ABC transporter; Region: ABC_tran_2; pfam12848 936157002465 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936157002466 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 936157002467 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 936157002468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157002469 active site 936157002470 motif I; other site 936157002471 motif II; other site 936157002472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157002473 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 936157002474 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 936157002475 dimer interface [polypeptide binding]; other site 936157002476 active site 936157002477 glycine loop; other site 936157002478 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 936157002479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157002480 FeS/SAM binding site; other site 936157002481 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 936157002482 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 936157002483 ATP binding site [chemical binding]; other site 936157002484 substrate interface [chemical binding]; other site 936157002485 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 936157002486 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 936157002487 dimer interface [polypeptide binding]; other site 936157002488 putative functional site; other site 936157002489 putative MPT binding site; other site 936157002490 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 936157002491 catalytic nucleophile [active] 936157002492 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936157002493 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 936157002494 Walker A/P-loop; other site 936157002495 ATP binding site [chemical binding]; other site 936157002496 Q-loop/lid; other site 936157002497 ABC transporter signature motif; other site 936157002498 Walker B; other site 936157002499 D-loop; other site 936157002500 H-loop/switch region; other site 936157002501 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 936157002502 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 936157002503 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936157002504 Walker A/P-loop; other site 936157002505 ATP binding site [chemical binding]; other site 936157002506 Q-loop/lid; other site 936157002507 ABC transporter signature motif; other site 936157002508 Walker B; other site 936157002509 D-loop; other site 936157002510 H-loop/switch region; other site 936157002511 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 936157002512 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 936157002513 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 936157002514 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 936157002515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157002516 dimer interface [polypeptide binding]; other site 936157002517 conserved gate region; other site 936157002518 putative PBP binding loops; other site 936157002519 ABC-ATPase subunit interface; other site 936157002520 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 936157002521 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 936157002522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157002523 dimer interface [polypeptide binding]; other site 936157002524 conserved gate region; other site 936157002525 putative PBP binding loops; other site 936157002526 ABC-ATPase subunit interface; other site 936157002527 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 936157002528 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 936157002529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157002530 FeS/SAM binding site; other site 936157002531 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 936157002532 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 936157002533 Ligand binding site [chemical binding]; other site 936157002534 Electron transfer flavoprotein domain; Region: ETF; pfam01012 936157002535 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 936157002536 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 936157002537 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 936157002538 Uncharacterized conserved protein [Function unknown]; Region: COG3777 936157002539 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 936157002540 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 936157002541 active site 936157002542 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 936157002543 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936157002544 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 936157002545 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 936157002546 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157002547 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157002548 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 936157002549 putative dimerization interface [polypeptide binding]; other site 936157002550 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 936157002551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 936157002552 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 936157002553 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 936157002554 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 936157002555 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 936157002556 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 936157002557 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 936157002558 putative C-terminal domain interface [polypeptide binding]; other site 936157002559 putative GSH binding site (G-site) [chemical binding]; other site 936157002560 putative dimer interface [polypeptide binding]; other site 936157002561 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 936157002562 putative N-terminal domain interface [polypeptide binding]; other site 936157002563 putative dimer interface [polypeptide binding]; other site 936157002564 putative substrate binding pocket (H-site) [chemical binding]; other site 936157002565 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 936157002566 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 936157002567 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 936157002568 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 936157002569 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 936157002570 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157002571 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 936157002572 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 936157002573 active site 936157002574 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 936157002575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157002576 putative substrate translocation pore; other site 936157002577 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 936157002578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157002579 active site 936157002580 motif I; other site 936157002581 motif II; other site 936157002582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157002583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157002584 putative substrate translocation pore; other site 936157002585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936157002586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 936157002587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157002588 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 936157002589 putative transporter; Provisional; Region: PRK04972 936157002590 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 936157002591 TrkA-C domain; Region: TrkA_C; pfam02080 936157002592 TrkA-C domain; Region: TrkA_C; pfam02080 936157002593 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 936157002594 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 936157002595 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 936157002596 GSH binding site [chemical binding]; other site 936157002597 catalytic residues [active] 936157002598 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 936157002599 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 936157002600 dimer interface [polypeptide binding]; other site 936157002601 FMN binding site [chemical binding]; other site 936157002602 NADPH bind site [chemical binding]; other site 936157002603 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 936157002604 RimK-like ATP-grasp domain; Region: RimK; pfam08443 936157002605 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 936157002606 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 936157002607 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 936157002608 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 936157002609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157002610 Walker A/P-loop; other site 936157002611 ATP binding site [chemical binding]; other site 936157002612 Q-loop/lid; other site 936157002613 ABC transporter signature motif; other site 936157002614 Walker B; other site 936157002615 D-loop; other site 936157002616 H-loop/switch region; other site 936157002617 TOBE domain; Region: TOBE_2; pfam08402 936157002618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157002619 dimer interface [polypeptide binding]; other site 936157002620 conserved gate region; other site 936157002621 putative PBP binding loops; other site 936157002622 ABC-ATPase subunit interface; other site 936157002623 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 936157002624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157002625 dimer interface [polypeptide binding]; other site 936157002626 conserved gate region; other site 936157002627 putative PBP binding loops; other site 936157002628 ABC-ATPase subunit interface; other site 936157002629 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 936157002630 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 936157002631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157002632 S-adenosylmethionine binding site [chemical binding]; other site 936157002633 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 936157002634 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 936157002635 active site 936157002636 P-loop; other site 936157002637 phosphorylation site [posttranslational modification] 936157002638 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 936157002639 Sulfatase; Region: Sulfatase; cl17466 936157002640 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 936157002641 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157002642 substrate binding pocket [chemical binding]; other site 936157002643 membrane-bound complex binding site; other site 936157002644 hinge residues; other site 936157002645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157002646 dimer interface [polypeptide binding]; other site 936157002647 conserved gate region; other site 936157002648 putative PBP binding loops; other site 936157002649 ABC-ATPase subunit interface; other site 936157002650 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 936157002651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157002652 dimer interface [polypeptide binding]; other site 936157002653 conserved gate region; other site 936157002654 putative PBP binding loops; other site 936157002655 ABC-ATPase subunit interface; other site 936157002656 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 936157002657 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157002658 substrate binding pocket [chemical binding]; other site 936157002659 membrane-bound complex binding site; other site 936157002660 hinge residues; other site 936157002661 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 936157002662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157002663 Walker A/P-loop; other site 936157002664 ATP binding site [chemical binding]; other site 936157002665 Q-loop/lid; other site 936157002666 ABC transporter signature motif; other site 936157002667 Walker B; other site 936157002668 D-loop; other site 936157002669 H-loop/switch region; other site 936157002670 putative lipoprotein; Provisional; Region: PRK10533 936157002671 hypothetical protein; Provisional; Region: PRK02877 936157002672 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 936157002673 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 936157002674 amidase catalytic site [active] 936157002675 Zn binding residues [ion binding]; other site 936157002676 substrate binding site [chemical binding]; other site 936157002677 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 936157002678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936157002679 NAD(P) binding site [chemical binding]; other site 936157002680 active site 936157002681 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 936157002682 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 936157002683 putative NAD(P) binding site [chemical binding]; other site 936157002684 putative active site [active] 936157002685 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 936157002686 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 936157002687 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 936157002688 tetramer interface [polypeptide binding]; other site 936157002689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157002690 catalytic residue [active] 936157002691 pyruvate dehydrogenase; Provisional; Region: PRK09124 936157002692 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 936157002693 PYR/PP interface [polypeptide binding]; other site 936157002694 dimer interface [polypeptide binding]; other site 936157002695 tetramer interface [polypeptide binding]; other site 936157002696 TPP binding site [chemical binding]; other site 936157002697 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 936157002698 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 936157002699 TPP-binding site [chemical binding]; other site 936157002700 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 936157002701 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 936157002702 FAD binding pocket [chemical binding]; other site 936157002703 FAD binding motif [chemical binding]; other site 936157002704 phosphate binding motif [ion binding]; other site 936157002705 beta-alpha-beta structure motif; other site 936157002706 NAD binding pocket [chemical binding]; other site 936157002707 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 936157002708 catalytic loop [active] 936157002709 iron binding site [ion binding]; other site 936157002710 hybrid cluster protein; Provisional; Region: PRK05290 936157002711 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936157002712 ACS interaction site; other site 936157002713 CODH interaction site; other site 936157002714 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 936157002715 hybrid metal cluster; other site 936157002716 Predicted membrane protein [Function unknown]; Region: COG2431 936157002717 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 936157002718 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 936157002719 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 936157002720 putative active site [active] 936157002721 putative metal-binding site [ion binding]; other site 936157002722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 936157002723 macrolide transporter subunit MacA; Provisional; Region: PRK11578 936157002724 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936157002725 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157002726 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 936157002727 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 936157002728 Walker A/P-loop; other site 936157002729 ATP binding site [chemical binding]; other site 936157002730 Q-loop/lid; other site 936157002731 ABC transporter signature motif; other site 936157002732 Walker B; other site 936157002733 D-loop; other site 936157002734 H-loop/switch region; other site 936157002735 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 936157002736 FtsX-like permease family; Region: FtsX; pfam02687 936157002737 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 936157002738 DNA-binding site [nucleotide binding]; DNA binding site 936157002739 RNA-binding motif; other site 936157002740 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 936157002741 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 936157002742 Clp amino terminal domain; Region: Clp_N; pfam02861 936157002743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157002744 Walker A motif; other site 936157002745 ATP binding site [chemical binding]; other site 936157002746 Walker B motif; other site 936157002747 arginine finger; other site 936157002748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157002749 Walker A motif; other site 936157002750 ATP binding site [chemical binding]; other site 936157002751 Walker B motif; other site 936157002752 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 936157002753 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 936157002754 DNA binding site [nucleotide binding] 936157002755 active site 936157002756 Int/Topo IB signature motif; other site 936157002757 Isochorismatase family; Region: Isochorismatase; pfam00857 936157002758 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 936157002759 catalytic triad [active] 936157002760 dimer interface [polypeptide binding]; other site 936157002761 conserved cis-peptide bond; other site 936157002762 Pirin-related protein [General function prediction only]; Region: COG1741 936157002763 Pirin; Region: Pirin; pfam02678 936157002764 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 936157002765 LysR family transcriptional regulator; Provisional; Region: PRK14997 936157002766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157002767 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 936157002768 putative effector binding pocket; other site 936157002769 putative dimerization interface [polypeptide binding]; other site 936157002770 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 936157002771 rRNA binding site [nucleotide binding]; other site 936157002772 predicted 30S ribosome binding site; other site 936157002773 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 936157002774 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 936157002775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936157002776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157002777 Walker A/P-loop; other site 936157002778 ATP binding site [chemical binding]; other site 936157002779 Q-loop/lid; other site 936157002780 ABC transporter signature motif; other site 936157002781 Walker B; other site 936157002782 D-loop; other site 936157002783 H-loop/switch region; other site 936157002784 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 936157002785 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936157002786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157002787 Walker A/P-loop; other site 936157002788 ATP binding site [chemical binding]; other site 936157002789 Q-loop/lid; other site 936157002790 ABC transporter signature motif; other site 936157002791 Walker B; other site 936157002792 D-loop; other site 936157002793 H-loop/switch region; other site 936157002794 thioredoxin reductase; Provisional; Region: PRK10262 936157002795 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936157002796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936157002797 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 936157002798 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936157002799 putative DNA binding site [nucleotide binding]; other site 936157002800 putative Zn2+ binding site [ion binding]; other site 936157002801 AsnC family; Region: AsnC_trans_reg; pfam01037 936157002802 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 936157002803 DNA translocase ftsK 936157002804 DNA translocase FtsK; Provisional; Region: PRK10263 936157002805 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 936157002806 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 936157002807 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 936157002808 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 936157002809 recombination factor protein RarA; Reviewed; Region: PRK13342 936157002810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157002811 Walker A motif; other site 936157002812 ATP binding site [chemical binding]; other site 936157002813 Walker B motif; other site 936157002814 arginine finger; other site 936157002815 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 936157002816 seryl-tRNA synthetase; Provisional; Region: PRK05431 936157002817 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 936157002818 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 936157002819 dimer interface [polypeptide binding]; other site 936157002820 active site 936157002821 motif 1; other site 936157002822 motif 2; other site 936157002823 motif 3; other site 936157002824 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 936157002825 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 936157002826 putative [Fe4-S4] binding site [ion binding]; other site 936157002827 putative molybdopterin cofactor binding site [chemical binding]; other site 936157002828 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 936157002829 putative molybdopterin cofactor binding site; other site 936157002830 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 936157002831 4Fe-4S binding domain; Region: Fer4; pfam00037 936157002832 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 936157002833 putative MFS family transporter protein; Provisional; Region: PRK03633 936157002834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157002835 putative substrate translocation pore; other site 936157002836 inner membrane transporter YjeM; Provisional; Region: PRK15238 936157002837 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 936157002838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157002839 FeS/SAM binding site; other site 936157002840 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 936157002841 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 936157002842 Pyruvate formate lyase 1; Region: PFL1; cd01678 936157002843 coenzyme A binding site [chemical binding]; other site 936157002844 active site 936157002845 catalytic residues [active] 936157002846 glycine loop; other site 936157002847 formate transporter; Provisional; Region: PRK10805 936157002848 uncharacterized domain; Region: TIGR00702 936157002849 YcaO-like family; Region: YcaO; pfam02624 936157002850 Predicted membrane protein [Function unknown]; Region: COG2323 936157002851 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 936157002852 homodimer interface [polypeptide binding]; other site 936157002853 substrate-cofactor binding pocket; other site 936157002854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157002855 catalytic residue [active] 936157002856 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 936157002857 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 936157002858 active site 936157002859 hinge; other site 936157002860 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 936157002861 cytidylate kinase; Provisional; Region: cmk; PRK00023 936157002862 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 936157002863 CMP-binding site; other site 936157002864 The sites determining sugar specificity; other site 936157002865 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 936157002866 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 936157002867 RNA binding site [nucleotide binding]; other site 936157002868 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 936157002869 RNA binding site [nucleotide binding]; other site 936157002870 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 936157002871 RNA binding site [nucleotide binding]; other site 936157002872 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 936157002873 RNA binding site [nucleotide binding]; other site 936157002874 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 936157002875 RNA binding site [nucleotide binding]; other site 936157002876 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 936157002877 IHF dimer interface [polypeptide binding]; other site 936157002878 IHF - DNA interface [nucleotide binding]; other site 936157002879 Helix-turn-helix domain; Region: HTH_28; pfam13518 936157002880 Integrase core domain; Region: rve; pfam00665 936157002881 Integrase core domain; Region: rve_3; pfam13683 936157002882 ComEC family competence protein; Provisional; Region: PRK11539 936157002883 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 936157002884 Competence protein; Region: Competence; pfam03772 936157002885 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 936157002886 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 936157002887 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936157002888 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 936157002889 Walker A/P-loop; other site 936157002890 ATP binding site [chemical binding]; other site 936157002891 Q-loop/lid; other site 936157002892 ABC transporter signature motif; other site 936157002893 Walker B; other site 936157002894 D-loop; other site 936157002895 H-loop/switch region; other site 936157002896 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 936157002897 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 936157002898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 936157002899 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 936157002900 hypothetical protein; Provisional; Region: PRK11827 936157002901 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 936157002902 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 936157002903 Ligand binding site; other site 936157002904 oligomer interface; other site 936157002905 hypothetical protein; Provisional; Region: PRK10593 936157002906 Uncharacterized conserved protein [Function unknown]; Region: COG1434 936157002907 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 936157002908 putative active site [active] 936157002909 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 936157002910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157002911 S-adenosylmethionine binding site [chemical binding]; other site 936157002912 KicB killing factor; Region: KicB; cl11468 936157002913 KicB killing factor; Region: KicB; cl11468 936157002914 condesin subunit E; Provisional; Region: PRK05256 936157002915 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 936157002916 P-loop containing region of AAA domain; Region: AAA_29; cl17516 936157002917 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 936157002918 murein L,D-transpeptidase; Provisional; Region: PRK10594 936157002919 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 936157002920 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 936157002921 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 936157002922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 936157002923 Peptidase M15; Region: Peptidase_M15_3; cl01194 936157002924 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 936157002925 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 936157002926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936157002927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157002928 homodimer interface [polypeptide binding]; other site 936157002929 catalytic residue [active] 936157002930 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 936157002931 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 936157002932 trimer interface [polypeptide binding]; other site 936157002933 eyelet of channel; other site 936157002934 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 936157002935 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 936157002936 putative dimer interface [polypeptide binding]; other site 936157002937 putative anticodon binding site; other site 936157002938 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 936157002939 homodimer interface [polypeptide binding]; other site 936157002940 motif 1; other site 936157002941 motif 2; other site 936157002942 active site 936157002943 motif 3; other site 936157002944 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 936157002945 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936157002946 putative DNA binding site [nucleotide binding]; other site 936157002947 putative Zn2+ binding site [ion binding]; other site 936157002948 AsnC family; Region: AsnC_trans_reg; pfam01037 936157002949 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 936157002950 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 936157002951 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936157002952 catalytic residue [active] 936157002953 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 936157002954 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 936157002955 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 936157002956 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 936157002957 active site 936157002958 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 936157002959 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 936157002960 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 936157002961 Int/Topo IB signature motif; other site 936157002962 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 936157002963 Exodeoxyribonuclease 8; Exodeoxyribonuclease VIII; EXO VIII;, Enterobacterial exodeoxyribonuclease VIII, Enterobacterial exodeoxyribonuclease VIII 936157002964 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 936157002965 DNA binding residues [nucleotide binding] 936157002966 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 936157002967 primosomal protein DnaI; Provisional; Region: PRK02854 936157002968 putative replication protein; Provisional; Region: PRK12377 936157002969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157002970 Walker A motif; other site 936157002971 ATP binding site [chemical binding]; other site 936157002972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 936157002973 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 936157002974 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 936157002975 DinI-like family; Region: DinI; pfam06183 936157002976 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 936157002977 Protein ninG;, Bacteriophage Lambda NinG protein, Bacteriophage lambda NinG 936157002978 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 936157002979 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 936157002980 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 936157002981 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 936157002982 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 936157002983 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 936157002984 hypothetical protein; Provisional; Region: PRK09951 936157002985 DinI-like family; Region: DinI; cl11630 936157002986 aminopeptidase N; Provisional; Region: pepN; PRK14015 936157002987 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 936157002988 active site 936157002989 Zn binding site [ion binding]; other site 936157002990 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 936157002991 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 936157002992 quinone interaction residues [chemical binding]; other site 936157002993 active site 936157002994 catalytic residues [active] 936157002995 FMN binding site [chemical binding]; other site 936157002996 substrate binding site [chemical binding]; other site 936157002997 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 936157002998 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 936157002999 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 936157003000 MOSC domain; Region: MOSC; pfam03473 936157003001 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 936157003002 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 936157003003 catalytic loop [active] 936157003004 iron binding site [ion binding]; other site 936157003005 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 936157003006 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 936157003007 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 936157003008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157003009 S-adenosylmethionine binding site [chemical binding]; other site 936157003010 ABC transporter ATPase component; Reviewed; Region: PRK11147 936157003011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157003012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157003013 Walker A/P-loop; other site 936157003014 Walker A/P-loop; other site 936157003015 ATP binding site [chemical binding]; other site 936157003016 ATP binding site [chemical binding]; other site 936157003017 Q-loop/lid; other site 936157003018 Q-loop/lid; other site 936157003019 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936157003020 ABC transporter signature motif; other site 936157003021 Walker B; other site 936157003022 D-loop; other site 936157003023 ABC transporter; Region: ABC_tran_2; pfam12848 936157003024 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936157003025 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 936157003026 Paraquat-inducible protein A; Region: PqiA; pfam04403 936157003027 Paraquat-inducible protein A; Region: PqiA; pfam04403 936157003028 paraquat-inducible protein B; Provisional; Region: PRK10807 936157003029 mce related protein; Region: MCE; pfam02470 936157003030 mce related protein; Region: MCE; pfam02470 936157003031 mce related protein; Region: MCE; pfam02470 936157003032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 936157003033 Protein of unknown function (DUF330); Region: DUF330; pfam03886 936157003034 ribosome modulation factor; Provisional; Region: PRK14563 936157003035 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 936157003036 active site 1 [active] 936157003037 dimer interface [polypeptide binding]; other site 936157003038 active site 2 [active] 936157003039 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 936157003040 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 936157003041 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 936157003042 outer membrane protein A; Reviewed; Region: PRK10808 936157003043 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 936157003044 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 936157003045 ligand binding site [chemical binding]; other site 936157003046 cell division inhibitor SulA; Region: sula; TIGR00623 936157003047 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 936157003048 TfoX C-terminal domain; Region: TfoX_C; pfam04994 936157003049 TIGR01666 family membrane protein; Region: YCCS 936157003050 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 936157003051 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 936157003052 Predicted membrane protein [Function unknown]; Region: COG3304 936157003053 Domain of unknown function (DUF307); Region: DUF307; pfam03733 936157003054 Domain of unknown function (DUF307); Region: DUF307; pfam03733 936157003055 DNA helicase IV; Provisional; Region: helD; PRK11054 936157003056 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 936157003057 Part of AAA domain; Region: AAA_19; pfam13245 936157003058 Family description; Region: UvrD_C_2; pfam13538 936157003059 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 936157003060 active site 936157003061 dimer interfaces [polypeptide binding]; other site 936157003062 catalytic residues [active] 936157003063 hypothetical protein; Provisional; Region: PRK03641 936157003064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 936157003065 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 936157003066 heat shock protein HspQ; Provisional; Region: PRK14129 936157003067 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 936157003068 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 936157003069 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 936157003070 putative RNA binding site [nucleotide binding]; other site 936157003071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157003072 S-adenosylmethionine binding site [chemical binding]; other site 936157003073 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 936157003074 substrate binding site [chemical binding]; other site 936157003075 Cupin domain; Region: Cupin_2; cl17218 936157003076 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936157003077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157003078 acylphosphatase; Provisional; Region: PRK14426 936157003079 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 936157003080 sulfur transfer protein TusE; Provisional; Region: PRK11508 936157003081 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 936157003082 YccA-like proteins; Region: YccA_like; cd10433 936157003083 PipA protein; Region: PipA; pfam07108 936157003084 secreted effector protein PipB; Provisional; Region: PRK15197 936157003085 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 936157003086 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 936157003087 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 936157003088 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 936157003089 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 936157003090 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 936157003091 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 936157003092 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 936157003093 HAMP domain; Region: HAMP; pfam00672 936157003094 dimerization interface [polypeptide binding]; other site 936157003095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157003096 dimer interface [polypeptide binding]; other site 936157003097 phosphorylation site [posttranslational modification] 936157003098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157003099 ATP binding site [chemical binding]; other site 936157003100 Mg2+ binding site [ion binding]; other site 936157003101 G-X-G motif; other site 936157003102 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 936157003103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157003104 active site 936157003105 phosphorylation site [posttranslational modification] 936157003106 intermolecular recognition site; other site 936157003107 dimerization interface [polypeptide binding]; other site 936157003108 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157003109 DNA binding site [nucleotide binding] 936157003110 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 936157003111 active site 936157003112 homotetramer interface [polypeptide binding]; other site 936157003113 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 936157003114 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 936157003115 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 936157003116 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 936157003117 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936157003118 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 936157003119 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 936157003120 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 936157003121 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 936157003122 NAD(P) binding site [chemical binding]; other site 936157003123 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 936157003124 NAD(P) binding site [chemical binding]; other site 936157003125 catalytic residues [active] 936157003126 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 936157003127 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 936157003128 putative active site [active] 936157003129 putative metal binding site [ion binding]; other site 936157003130 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 936157003131 putative substrate binding pocket [chemical binding]; other site 936157003132 trimer interface [polypeptide binding]; other site 936157003133 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 936157003134 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 936157003135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157003136 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 936157003137 putative substrate translocation pore; other site 936157003138 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 936157003139 Cupin domain; Region: Cupin_2; pfam07883 936157003140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157003141 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 936157003142 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 936157003143 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 936157003144 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 936157003145 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 936157003146 HSP70 interaction site [polypeptide binding]; other site 936157003147 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 936157003148 substrate binding site [polypeptide binding]; other site 936157003149 dimer interface [polypeptide binding]; other site 936157003150 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 936157003151 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 936157003152 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 936157003153 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 936157003154 DsbD alpha interface [polypeptide binding]; other site 936157003155 catalytic residues [active] 936157003156 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 936157003157 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 936157003158 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 936157003159 catalytic residues [active] 936157003160 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 936157003161 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 936157003162 catalytic residues [active] 936157003163 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 936157003164 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 936157003165 catalytic core [active] 936157003166 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 936157003167 hypothetical protein; Provisional; Region: PRK10174 936157003168 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 936157003169 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 936157003170 General stress protein [General function prediction only]; Region: GsiB; COG3729 936157003171 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 936157003172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157003173 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 936157003174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 936157003175 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 936157003176 Predicted transcriptional regulator [Transcription]; Region: COG3905 936157003177 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 936157003178 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 936157003179 Glutamate binding site [chemical binding]; other site 936157003180 NAD binding site [chemical binding]; other site 936157003181 catalytic residues [active] 936157003182 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 936157003183 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 936157003184 Na binding site [ion binding]; other site 936157003185 hypothetical protein; Provisional; Region: PRK10536 936157003186 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 936157003187 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 936157003188 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 936157003189 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 936157003190 putative active site [active] 936157003191 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 936157003192 Na binding site [ion binding]; other site 936157003193 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 936157003194 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 936157003195 putative active site cavity [active] 936157003196 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 936157003197 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 936157003198 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 936157003199 putative sialic acid transporter; Provisional; Region: PRK12307 936157003200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157003201 putative substrate translocation pore; other site 936157003202 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936157003203 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936157003204 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936157003205 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 936157003206 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936157003207 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 936157003208 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 936157003209 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 936157003210 ImpA domain protein; Region: DUF3702; pfam12486 936157003211 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 936157003212 AAA domain; Region: AAA_17; pfam13207 936157003213 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 936157003214 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 936157003215 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 936157003216 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 936157003217 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 936157003218 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 936157003219 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 936157003220 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 936157003221 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 936157003222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157003223 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 936157003224 Walker A motif; other site 936157003225 ATP binding site [chemical binding]; other site 936157003226 Walker B motif; other site 936157003227 arginine finger; other site 936157003228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 936157003229 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 936157003230 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 936157003231 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 936157003232 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 936157003233 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 936157003234 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 936157003235 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 936157003236 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 936157003237 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 936157003238 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 936157003239 Protein of unknown function (DUF877); Region: DUF877; pfam05943 936157003240 Protein of unknown function (DUF770); Region: DUF770; pfam05591 936157003241 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 936157003242 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 936157003243 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 936157003244 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 936157003245 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 936157003246 Protein rhsB;, RHS protein, YD repeat 936157003247 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 936157003248 RHS protein; Region: RHS; pfam03527 936157003249 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 936157003250 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 936157003251 RHS protein; Region: RHS; pfam03527 936157003252 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 936157003253 Transposase, Mutator family; Region: Transposase_mut; pfam00872 936157003254 MULE transposase domain; Region: MULE; pfam10551 936157003255 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936157003256 Sel1-like repeats; Region: SEL1; smart00671 936157003257 Sel1-like repeats; Region: SEL1; smart00671 936157003258 Sel1-like repeats; Region: SEL1; smart00671 936157003259 dsRNA-gated channel SID-1; Region: SID-1_RNA_chan; pfam13965 936157003260 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 936157003261 DNA-binding site [nucleotide binding]; DNA binding site 936157003262 RNA-binding motif; other site 936157003263 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 936157003264 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 936157003265 trimer interface [polypeptide binding]; other site 936157003266 eyelet of channel; other site 936157003267 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 936157003268 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936157003269 Zn2+ binding site [ion binding]; other site 936157003270 Mg2+ binding site [ion binding]; other site 936157003271 DNA cytosine methylase; Provisional; Region: PRK10458 936157003272 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 936157003273 cofactor binding site; other site 936157003274 DNA binding site [nucleotide binding] 936157003275 substrate interaction site [chemical binding]; other site 936157003276 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 936157003277 additional DNA contacts [nucleotide binding]; other site 936157003278 mismatch recognition site; other site 936157003279 active site 936157003280 zinc binding site [ion binding]; other site 936157003281 DNA intercalation site [nucleotide binding]; other site 936157003282 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 936157003283 EamA-like transporter family; Region: EamA; pfam00892 936157003284 EamA-like transporter family; Region: EamA; pfam00892 936157003285 hypothetical protein; Provisional; Region: PRK10062 936157003286 Uncharacterized small protein [Function unknown]; Region: COG5475 936157003287 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 936157003288 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936157003289 metal binding site [ion binding]; metal-binding site 936157003290 active site 936157003291 I-site; other site 936157003292 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 936157003293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157003294 active site 936157003295 motif I; other site 936157003296 motif II; other site 936157003297 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 936157003298 hypothetical protein; Provisional; Region: PRK10708 936157003299 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 936157003300 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157003301 DNA binding residues [nucleotide binding] 936157003302 dimerization interface [polypeptide binding]; other site 936157003303 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 936157003304 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 936157003305 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 936157003306 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 936157003307 flagellar motor switch protein; Validated; Region: fliN; PRK05698 936157003308 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 936157003309 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 936157003310 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 936157003311 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 936157003312 flagellar hook-length control protein; Provisional; Region: PRK10118 936157003313 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 936157003314 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 936157003315 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 936157003316 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 936157003317 Walker A motif/ATP binding site; other site 936157003318 Walker B motif; other site 936157003319 flagellar assembly protein H; Validated; Region: fliH; PRK05687 936157003320 Flagellar assembly protein FliH; Region: FliH; pfam02108 936157003321 flagellar motor switch protein FliG; Region: fliG; TIGR00207 936157003322 FliG C-terminal domain; Region: FliG_C; pfam01706 936157003323 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 936157003324 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 936157003325 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 936157003326 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 936157003327 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 936157003328 CPxP motif; other site 936157003329 putative inner membrane protein; Provisional; Region: PRK11099 936157003330 Sulphur transport; Region: Sulf_transp; pfam04143 936157003331 lipoprotein; Provisional; Region: PRK10397 936157003332 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 936157003333 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 936157003334 active site 936157003335 Na/Ca binding site [ion binding]; other site 936157003336 catalytic site [active] 936157003337 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 936157003338 flagellar protein FliS; Validated; Region: fliS; PRK05685 936157003339 flagellar capping protein; Reviewed; Region: fliD; PRK08032 936157003340 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 936157003341 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 936157003342 flagellin; Validated; Region: PRK08026 936157003343 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 936157003344 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 936157003345 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 936157003346 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 936157003347 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936157003348 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 936157003349 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936157003350 DNA binding residues [nucleotide binding] 936157003351 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 936157003352 cystine transporter subunit; Provisional; Region: PRK11260 936157003353 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157003354 substrate binding pocket [chemical binding]; other site 936157003355 membrane-bound complex binding site; other site 936157003356 hinge residues; other site 936157003357 D-cysteine desulfhydrase; Validated; Region: PRK03910 936157003358 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 936157003359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157003360 catalytic residue [active] 936157003361 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 936157003362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157003363 dimer interface [polypeptide binding]; other site 936157003364 conserved gate region; other site 936157003365 putative PBP binding loops; other site 936157003366 ABC-ATPase subunit interface; other site 936157003367 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 936157003368 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 936157003369 Walker A/P-loop; other site 936157003370 ATP binding site [chemical binding]; other site 936157003371 Q-loop/lid; other site 936157003372 ABC transporter signature motif; other site 936157003373 Walker B; other site 936157003374 D-loop; other site 936157003375 H-loop/switch region; other site 936157003376 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 936157003377 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 936157003378 Autoinducer binding domain; Region: Autoind_bind; pfam03472 936157003379 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157003380 DNA binding residues [nucleotide binding] 936157003381 dimerization interface [polypeptide binding]; other site 936157003382 hypothetical protein; Provisional; Region: PRK10613 936157003383 response regulator; Provisional; Region: PRK09483 936157003384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157003385 active site 936157003386 phosphorylation site [posttranslational modification] 936157003387 intermolecular recognition site; other site 936157003388 dimerization interface [polypeptide binding]; other site 936157003389 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157003390 DNA binding residues [nucleotide binding] 936157003391 dimerization interface [polypeptide binding]; other site 936157003392 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 936157003393 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 936157003394 GIY-YIG motif/motif A; other site 936157003395 active site 936157003396 catalytic site [active] 936157003397 putative DNA binding site [nucleotide binding]; other site 936157003398 metal binding site [ion binding]; metal-binding site 936157003399 UvrB/uvrC motif; Region: UVR; pfam02151 936157003400 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 936157003401 Helix-hairpin-helix motif; Region: HHH; pfam00633 936157003402 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 936157003403 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 936157003404 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 936157003405 NlpC/P60 family; Region: NLPC_P60; cl17555 936157003406 glucose-6-phosphate 1-dehydrogenase; Region: PLN02640 936157003407 hypothetical protein; Provisional; Region: PRK10396 936157003408 yecA family protein; Region: ygfB_yecA; TIGR02292 936157003409 SEC-C motif; Region: SEC-C; pfam02810 936157003410 tyrosine transporter TyrP; Provisional; Region: PRK15132 936157003411 aromatic amino acid transport protein; Region: araaP; TIGR00837 936157003412 probable metal-binding protein; Region: matur_matur; TIGR03853 936157003413 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 936157003414 Ferritin-like domain; Region: Ferritin; pfam00210 936157003415 ferroxidase diiron center [ion binding]; other site 936157003416 YecR-like lipoprotein; Region: YecR; pfam13992 936157003417 hypothetical protein; Provisional; Region: PRK09273 936157003418 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 936157003419 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 936157003420 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 936157003421 Ferritin-like domain; Region: Ferritin; pfam00210 936157003422 ferroxidase diiron center [ion binding]; other site 936157003423 DJ-1 family protein; Region: not_thiJ; TIGR01383 936157003424 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 936157003425 conserved cys residue [active] 936157003426 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 936157003427 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 936157003428 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 936157003429 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 936157003430 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 936157003431 active site 936157003432 homotetramer interface [polypeptide binding]; other site 936157003433 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 936157003434 Ligand Binding Site [chemical binding]; other site 936157003435 transcriptional activator FlhD; Provisional; Region: PRK02909 936157003436 transcriptional activator FlhC; Provisional; Region: PRK12722 936157003437 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 936157003438 flagellar motor protein MotA; Validated; Region: PRK09110 936157003439 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 936157003440 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 936157003441 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 936157003442 ligand binding site [chemical binding]; other site 936157003443 chemotaxis protein CheA; Provisional; Region: PRK10547 936157003444 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 936157003445 putative binding surface; other site 936157003446 active site 936157003447 CheY binding; Region: CheY-binding; pfam09078 936157003448 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 936157003449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157003450 ATP binding site [chemical binding]; other site 936157003451 Mg2+ binding site [ion binding]; other site 936157003452 G-X-G motif; other site 936157003453 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 936157003454 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 936157003455 putative CheA interaction surface; other site 936157003456 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 936157003457 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 936157003458 dimer interface [polypeptide binding]; other site 936157003459 ligand binding site [chemical binding]; other site 936157003460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157003461 dimerization interface [polypeptide binding]; other site 936157003462 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936157003463 dimer interface [polypeptide binding]; other site 936157003464 putative CheW interface [polypeptide binding]; other site 936157003465 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 936157003466 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 936157003467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157003468 S-adenosylmethionine binding site [chemical binding]; other site 936157003469 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 936157003470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157003471 active site 936157003472 phosphorylation site [posttranslational modification] 936157003473 intermolecular recognition site; other site 936157003474 dimerization interface [polypeptide binding]; other site 936157003475 CheB methylesterase; Region: CheB_methylest; pfam01339 936157003476 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 936157003477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157003478 active site 936157003479 phosphorylation site [posttranslational modification] 936157003480 intermolecular recognition site; other site 936157003481 dimerization interface [polypeptide binding]; other site 936157003482 chemotaxis regulator CheZ; Provisional; Region: PRK11166 936157003483 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 936157003484 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 936157003485 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 936157003486 FHIPEP family; Region: FHIPEP; pfam00771 936157003487 Flagellar protein FlhE; Region: FlhE; pfam06366 936157003488 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 936157003489 penicillin-binding protein 2; Provisional; Region: PRK10795 936157003490 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936157003491 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936157003492 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 936157003493 arginyl-tRNA synthetase; Region: argS; TIGR00456 936157003494 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 936157003495 active site 936157003496 HIGH motif; other site 936157003497 KMSK motif region; other site 936157003498 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 936157003499 tRNA binding surface [nucleotide binding]; other site 936157003500 anticodon binding site; other site 936157003501 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 936157003502 putative metal binding site [ion binding]; other site 936157003503 copper homeostasis protein CutC; Provisional; Region: PRK11572 936157003504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157003505 S-adenosylmethionine binding site [chemical binding]; other site 936157003506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157003507 S-adenosylmethionine binding site [chemical binding]; other site 936157003508 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 936157003509 hypothetical protein; Provisional; Region: PRK10302 936157003510 Isochorismatase family; Region: Isochorismatase; pfam00857 936157003511 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 936157003512 catalytic triad [active] 936157003513 conserved cis-peptide bond; other site 936157003514 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 936157003515 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 936157003516 dimer interface [polypeptide binding]; other site 936157003517 anticodon binding site; other site 936157003518 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 936157003519 homodimer interface [polypeptide binding]; other site 936157003520 motif 1; other site 936157003521 active site 936157003522 motif 2; other site 936157003523 GAD domain; Region: GAD; pfam02938 936157003524 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 936157003525 active site 936157003526 motif 3; other site 936157003527 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 936157003528 nudix motif; other site 936157003529 hypothetical protein; Validated; Region: PRK00110 936157003530 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 936157003531 active site 936157003532 putative DNA-binding cleft [nucleotide binding]; other site 936157003533 dimer interface [polypeptide binding]; other site 936157003534 hypothetical protein; Provisional; Region: PRK11470 936157003535 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 936157003536 RuvA N terminal domain; Region: RuvA_N; pfam01330 936157003537 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 936157003538 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 936157003539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157003540 Walker A motif; other site 936157003541 ATP binding site [chemical binding]; other site 936157003542 Walker B motif; other site 936157003543 arginine finger; other site 936157003544 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 936157003545 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 936157003546 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936157003547 ABC-ATPase subunit interface; other site 936157003548 dimer interface [polypeptide binding]; other site 936157003549 putative PBP binding regions; other site 936157003550 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 936157003551 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 936157003552 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 936157003553 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 936157003554 metal binding site [ion binding]; metal-binding site 936157003555 putative peptidase; Provisional; Region: PRK11649 936157003556 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 936157003557 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936157003558 Peptidase family M23; Region: Peptidase_M23; pfam01551 936157003559 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 936157003560 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 936157003561 putative acyl-acceptor binding pocket; other site 936157003562 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 936157003563 ORF6N domain; Region: ORF6N; pfam10543 936157003564 PipA protein; Region: PipA; pfam07108 936157003565 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 936157003566 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 936157003567 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 936157003568 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 936157003569 gpW; Region: gpW; pfam02831 936157003570 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 936157003571 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 936157003572 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 936157003573 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 936157003574 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 936157003575 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 936157003576 tandem repeat interface [polypeptide binding]; other site 936157003577 oligomer interface [polypeptide binding]; other site 936157003578 active site residues [active] 936157003579 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 936157003580 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 936157003581 DNA packaging protein FI; Region: Packaging_FI; pfam14000 936157003582 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 936157003583 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 936157003584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 936157003585 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 936157003586 Probable transposase; Region: OrfB_IS605; pfam01385 936157003587 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 936157003588 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 936157003589 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 936157003590 Phage tail protein; Region: Phage_tail_3; pfam08813 936157003591 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 936157003592 Minor tail protein T; Region: Phage_tail_T; pfam06223 936157003593 Phage-related minor tail protein [Function unknown]; Region: COG5281 936157003594 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 936157003595 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 936157003596 Phage-related protein [Function unknown]; Region: COG4718 936157003597 Phage-related protein [Function unknown]; Region: gp18; COG4672 936157003598 Tail assembly protein K;, Mov34/MPN/PAD-1 936157003599 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 936157003600 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 936157003601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157003602 putative substrate translocation pore; other site 936157003603 lipoprotein; Provisional; Region: PRK10759 936157003604 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 936157003605 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 936157003606 domain interface [polypeptide binding]; other site 936157003607 putative active site [active] 936157003608 catalytic site [active] 936157003609 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 936157003610 domain interface [polypeptide binding]; other site 936157003611 putative active site [active] 936157003612 catalytic site [active] 936157003613 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 936157003614 CoA binding domain; Region: CoA_binding_2; pfam13380 936157003615 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 936157003616 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 936157003617 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 936157003618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157003619 Coenzyme A binding pocket [chemical binding]; other site 936157003620 Uncharacterized conserved protein [Function unknown]; Region: COG3148 936157003621 thioredoxin 2; Provisional; Region: PRK10996 936157003622 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 936157003623 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 936157003624 catalytic residues [active] 936157003625 putative methyltransferase; Provisional; Region: PRK10864 936157003626 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 936157003627 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 936157003628 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 936157003629 ligand binding site [chemical binding]; other site 936157003630 active site 936157003631 UGI interface [polypeptide binding]; other site 936157003632 catalytic site [active] 936157003633 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 936157003634 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 936157003635 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157003636 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157003637 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936157003638 dimerization interface [polypeptide binding]; other site 936157003639 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 936157003640 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 936157003641 ATP binding site [chemical binding]; other site 936157003642 Mg++ binding site [ion binding]; other site 936157003643 motif III; other site 936157003644 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157003645 nucleotide binding region [chemical binding]; other site 936157003646 ATP-binding site [chemical binding]; other site 936157003647 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 936157003648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157003649 S-adenosylmethionine binding site [chemical binding]; other site 936157003650 L-aspartate oxidase; Provisional; Region: PRK09077 936157003651 L-aspartate oxidase; Provisional; Region: PRK06175 936157003652 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 936157003653 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 936157003654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936157003655 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936157003656 DNA binding residues [nucleotide binding] 936157003657 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 936157003658 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 936157003659 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 936157003660 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 936157003661 anti-sigma E factor; Provisional; Region: rseB; PRK09455 936157003662 SoxR reducing system protein RseC; Provisional; Region: PRK10862 936157003663 integrase; Provisional; Region: PRK09692 936157003664 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 936157003665 active site 936157003666 Int/Topo IB signature motif; other site 936157003667 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 936157003668 RecT family; Region: RecT; pfam03837 936157003669 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 936157003670 exonuclease VIII; Reviewed; Region: PRK09709 936157003671 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 936157003672 transcriptional repressor DicA; Reviewed; Region: PRK09706 936157003673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157003674 non-specific DNA binding site [nucleotide binding]; other site 936157003675 salt bridge; other site 936157003676 sequence-specific DNA binding site [nucleotide binding]; other site 936157003677 Bacteriophage CII protein; Region: Phage_CII; pfam05269 936157003678 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 936157003679 Replication protein P; Region: Phage_lambda_P; pfam06992 936157003680 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 936157003681 Protein of unknown function (DUF550); Region: DUF550; pfam04447 936157003682 Protein of unknown function (DUF551); Region: DUF551; pfam04448 936157003683 DinI-like family; Region: DinI; pfam06183 936157003684 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 936157003685 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 936157003686 Antitermination protein; Region: Antiterm; pfam03589 936157003687 Antitermination protein; Region: Antiterm; pfam03589 936157003688 PipA protein; Region: PipA; pfam07108 936157003689 phage holin, lambda family; Region: holin_lambda; TIGR01594 936157003690 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 936157003691 catalytic residues [active] 936157003692 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 936157003693 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 936157003694 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 936157003695 Domain of unknown function (DUF1859); Region: DUF1859; pfam08948 936157003696 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 936157003697 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 936157003698 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 936157003699 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 936157003700 oligomer interface [polypeptide binding]; other site 936157003701 active site residues [active] 936157003702 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 936157003703 Uncharacterized conserved protein [Function unknown]; Region: COG5471 936157003704 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 936157003705 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 936157003706 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 936157003707 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 936157003708 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 936157003709 Minor tail protein T; Region: Phage_tail_T; cl05636 936157003710 Phage-related minor tail protein [Function unknown]; Region: COG5281 936157003711 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 936157003712 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 936157003713 Phage-related protein [Function unknown]; Region: COG4718 936157003714 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 936157003715 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 936157003716 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 936157003717 E-class dimer interface [polypeptide binding]; other site 936157003718 P-class dimer interface [polypeptide binding]; other site 936157003719 active site 936157003720 Cu2+ binding site [ion binding]; other site 936157003721 Zn2+ binding site [ion binding]; other site 936157003722 Phage-related protein [Function unknown]; Region: gp18; COG4672 936157003723 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 936157003724 MPN+ (JAMM) motif; other site 936157003725 Zinc-binding site [ion binding]; other site 936157003726 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 936157003727 NlpC/P60 family; Region: NLPC_P60; cl17555 936157003728 Phage-related protein, tail component [Function unknown]; Region: COG4723 936157003729 Phage-related protein, tail component [Function unknown]; Region: COG4733 936157003730 Putative phage tail protein; Region: Phage-tail_3; pfam13550 936157003731 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 936157003732 Interdomain contacts; other site 936157003733 Cytokine receptor motif; other site 936157003734 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 936157003735 Fibronectin type III protein; Region: DUF3672; pfam12421 936157003736 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 936157003737 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 936157003738 Phage Tail Collar Domain; Region: Collar; pfam07484 936157003739 Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900 936157003740 ADP-ribose binding site [chemical binding]; other site 936157003741 putative active site [active] 936157003742 dimer interface [polypeptide binding]; other site 936157003743 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 936157003744 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 936157003745 Lambda phage tail tape-measure protein (Tape_meas_lam_C), tape_meas_lam_C: phage tail tape measure protein, lambda family, Phage tail tape measure protein 936157003746 Host specificity protein J;, Domain of unknown function (DUF1983), Fibronectin, type III 936157003747 Integrase;, Integrase, catalytic core, phage 936157003748 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 936157003749 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 936157003750 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 936157003751 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 936157003752 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157003753 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 936157003754 substrate binding pocket [chemical binding]; other site 936157003755 membrane-bound complex binding site; other site 936157003756 hinge residues; other site 936157003757 pyruvate kinase; Provisional; Region: PRK05826 936157003758 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 936157003759 domain interfaces; other site 936157003760 active site 936157003761 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 936157003762 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 936157003763 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 936157003764 putative active site [active] 936157003765 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 936157003766 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 936157003767 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 936157003768 phosphogluconate dehydratase; Validated; Region: PRK09054 936157003769 6-phosphogluconate dehydratase; Region: edd; TIGR01196 936157003770 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 936157003771 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 936157003772 active site 936157003773 intersubunit interface [polypeptide binding]; other site 936157003774 catalytic residue [active] 936157003775 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 936157003776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 936157003777 ATP-grasp domain; Region: ATP-grasp; pfam02222 936157003778 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 936157003779 YebF-like protein; Region: YebF; cl10126 936157003780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 936157003781 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 936157003782 putative metal binding site [ion binding]; other site 936157003783 protease 2; Provisional; Region: PRK10115 936157003784 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 936157003785 exodeoxyribonuclease X; Provisional; Region: PRK07983 936157003786 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 936157003787 active site 936157003788 catalytic site [active] 936157003789 substrate binding site [chemical binding]; other site 936157003790 Predicted amidohydrolase [General function prediction only]; Region: COG0388 936157003791 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 936157003792 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 936157003793 hypothetical protein; Provisional; Region: PRK10301 936157003794 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 936157003795 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 936157003796 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 936157003797 DNA binding site [nucleotide binding] 936157003798 active site 936157003799 Int/Topo IB signature motif; other site 936157003800 RecT family; Region: RecT; cl04285 936157003801 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 936157003802 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936157003803 metal binding site [ion binding]; metal-binding site 936157003804 active site 936157003805 I-site; other site 936157003806 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 936157003807 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 936157003808 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 936157003809 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936157003810 EamA-like transporter family; Region: EamA; pfam00892 936157003811 EamA-like transporter family; Region: EamA; pfam00892 936157003812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 936157003813 MULE transposase domain; Region: MULE; pfam10551 936157003814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157003815 Coenzyme A binding pocket [chemical binding]; other site 936157003816 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 936157003817 type III secretion protein SopE2; Provisional; Region: PRK15280 936157003818 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 936157003819 SopE GEF domain; Region: SopE_GEF; pfam07487 936157003820 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 936157003821 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 936157003822 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 936157003823 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 936157003824 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 936157003825 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 936157003826 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 936157003827 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 936157003828 mce related protein; Region: MCE; pfam02470 936157003829 mce related protein; Region: MCE; pfam02470 936157003830 mce related protein; Region: MCE; pfam02470 936157003831 mce related protein; Region: MCE; pfam02470 936157003832 mce related protein; Region: MCE; pfam02470 936157003833 mce related protein; Region: MCE; pfam02470 936157003834 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 936157003835 Paraquat-inducible protein A; Region: PqiA; pfam04403 936157003836 Paraquat-inducible protein A; Region: PqiA; pfam04403 936157003837 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 936157003838 GAF domain; Region: GAF_2; pfam13185 936157003839 ProP expression regulator; Provisional; Region: PRK04950 936157003840 ProQ/FINO family; Region: ProQ; pfam04352 936157003841 carboxy-terminal protease; Provisional; Region: PRK11186 936157003842 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 936157003843 protein binding site [polypeptide binding]; other site 936157003844 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 936157003845 Catalytic dyad [active] 936157003846 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 936157003847 heat shock protein HtpX; Provisional; Region: PRK05457 936157003848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157003849 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936157003850 putative substrate translocation pore; other site 936157003851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157003852 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 936157003853 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936157003854 dimerization interface [polypeptide binding]; other site 936157003855 putative Zn2+ binding site [ion binding]; other site 936157003856 putative DNA binding site [nucleotide binding]; other site 936157003857 Bacterial transcriptional regulator; Region: IclR; pfam01614 936157003858 YobH-like protein; Region: YobH; pfam13996 936157003859 PhoPQ regulatory protein; Provisional; Region: PRK10299 936157003860 YebO-like protein; Region: YebO; pfam13974 936157003861 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 936157003862 DNA-binding site [nucleotide binding]; DNA binding site 936157003863 RNA-binding motif; other site 936157003864 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 936157003865 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 936157003866 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 936157003867 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 936157003868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157003869 S-adenosylmethionine binding site [chemical binding]; other site 936157003870 hypothetical protein; Provisional; Region: PRK11469 936157003871 Domain of unknown function DUF; Region: DUF204; pfam02659 936157003872 Domain of unknown function DUF; Region: DUF204; pfam02659 936157003873 hypothetical protein; Provisional; Region: PRK02913 936157003874 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 936157003875 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 936157003876 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 936157003877 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 936157003878 active pocket/dimerization site; other site 936157003879 active site 936157003880 phosphorylation site [posttranslational modification] 936157003881 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 936157003882 active site 936157003883 phosphorylation site [posttranslational modification] 936157003884 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 936157003885 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 936157003886 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 936157003887 Transporter associated domain; Region: CorC_HlyC; smart01091 936157003888 phage resistance protein; Provisional; Region: PRK10551 936157003889 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 936157003890 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157003891 L-serine deaminase; Provisional; Region: PRK15023 936157003892 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 936157003893 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 936157003894 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 936157003895 putative active site [active] 936157003896 putative CoA binding site [chemical binding]; other site 936157003897 nudix motif; other site 936157003898 metal binding site [ion binding]; metal-binding site 936157003899 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 936157003900 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 936157003901 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 936157003902 hypothetical protein; Provisional; Region: PRK05114 936157003903 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 936157003904 homotrimer interaction site [polypeptide binding]; other site 936157003905 putative active site [active] 936157003906 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 936157003907 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 936157003908 DEAD_2; Region: DEAD_2; pfam06733 936157003909 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 936157003910 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 936157003911 Glycoprotease family; Region: Peptidase_M22; pfam00814 936157003912 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 936157003913 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 936157003914 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 936157003915 acyl-activating enzyme (AAE) consensus motif; other site 936157003916 putative AMP binding site [chemical binding]; other site 936157003917 putative active site [active] 936157003918 putative CoA binding site [chemical binding]; other site 936157003919 ribonuclease D; Provisional; Region: PRK10829 936157003920 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 936157003921 catalytic site [active] 936157003922 putative active site [active] 936157003923 putative substrate binding site [chemical binding]; other site 936157003924 HRDC domain; Region: HRDC; cl02578 936157003925 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 936157003926 cell division inhibitor MinD; Provisional; Region: PRK10818 936157003927 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 936157003928 Switch I; other site 936157003929 Switch II; other site 936157003930 septum formation inhibitor; Reviewed; Region: minC; PRK03511 936157003931 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 936157003932 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 936157003933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 936157003934 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 936157003935 hypothetical protein; Provisional; Region: PRK10691 936157003936 hypothetical protein; Provisional; Region: PRK05170 936157003937 GnsA/GnsB family; Region: GnsAB; pfam08178 936157003938 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 936157003939 disulfide bond formation protein B; Provisional; Region: PRK01749 936157003940 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 936157003941 transmembrane helices; other site 936157003942 fatty acid metabolism regulator; Provisional; Region: PRK04984 936157003943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157003944 DNA-binding site [nucleotide binding]; DNA binding site 936157003945 FadR C-terminal domain; Region: FadR_C; pfam07840 936157003946 SpoVR family protein; Provisional; Region: PRK11767 936157003947 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 936157003948 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 936157003949 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 936157003950 alanine racemase; Reviewed; Region: dadX; PRK03646 936157003951 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 936157003952 active site 936157003953 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936157003954 substrate binding site [chemical binding]; other site 936157003955 catalytic residues [active] 936157003956 dimer interface [polypeptide binding]; other site 936157003957 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 936157003958 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 936157003959 TrkA-C domain; Region: TrkA_C; pfam02080 936157003960 Transporter associated domain; Region: CorC_HlyC; smart01091 936157003961 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 936157003962 dimer interface [polypeptide binding]; other site 936157003963 catalytic triad [active] 936157003964 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 936157003965 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936157003966 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936157003967 catalytic residue [active] 936157003968 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 936157003969 Flagellar regulator YcgR; Region: YcgR; pfam07317 936157003970 PilZ domain; Region: PilZ; pfam07238 936157003971 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 936157003972 trehalase; Provisional; Region: treA; PRK13271 936157003973 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 936157003974 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 936157003975 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 936157003976 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 936157003977 NAD(P) binding site [chemical binding]; other site 936157003978 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 936157003979 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 936157003980 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 936157003981 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 936157003982 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 936157003983 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 936157003984 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 936157003985 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 936157003986 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 936157003987 putative substrate-binding site; other site 936157003988 nickel binding site [ion binding]; other site 936157003989 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 936157003990 hydrogenase 1 large subunit; Provisional; Region: PRK10170 936157003991 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 936157003992 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 936157003993 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 936157003994 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 936157003995 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 936157003996 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 936157003997 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 936157003998 GTP-binding protein YchF; Reviewed; Region: PRK09601 936157003999 YchF GTPase; Region: YchF; cd01900 936157004000 G1 box; other site 936157004001 GTP/Mg2+ binding site [chemical binding]; other site 936157004002 Switch I region; other site 936157004003 G2 box; other site 936157004004 Switch II region; other site 936157004005 G3 box; other site 936157004006 G4 box; other site 936157004007 G5 box; other site 936157004008 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 936157004009 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 936157004010 putative active site [active] 936157004011 catalytic residue [active] 936157004012 hypothetical protein; Provisional; Region: PRK10692 936157004013 putative transporter; Provisional; Region: PRK11660 936157004014 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 936157004015 Sulfate transporter family; Region: Sulfate_transp; pfam00916 936157004016 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 936157004017 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 936157004018 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 936157004019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936157004020 active site 936157004021 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 936157004022 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 936157004023 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 936157004024 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 936157004025 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 936157004026 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 936157004027 tRNA; other site 936157004028 putative tRNA binding site [nucleotide binding]; other site 936157004029 putative NADP binding site [chemical binding]; other site 936157004030 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 936157004031 peptide chain release factor 1; Validated; Region: prfA; PRK00591 936157004032 This domain is found in peptide chain release factors; Region: PCRF; smart00937 936157004033 RF-1 domain; Region: RF-1; pfam00472 936157004034 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 936157004035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157004036 hypothetical protein; Provisional; Region: PRK10278 936157004037 hypothetical protein; Provisional; Region: PRK10941 936157004038 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 936157004039 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 936157004040 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 936157004041 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 936157004042 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 936157004043 cation transport regulator; Reviewed; Region: chaB; PRK09582 936157004044 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 936157004045 putative invasin; Provisional; Region: PRK10177 936157004046 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 936157004047 transcriptional regulator NarL; Provisional; Region: PRK10651 936157004048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157004049 active site 936157004050 phosphorylation site [posttranslational modification] 936157004051 intermolecular recognition site; other site 936157004052 dimerization interface [polypeptide binding]; other site 936157004053 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157004054 DNA binding residues [nucleotide binding] 936157004055 dimerization interface [polypeptide binding]; other site 936157004056 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 936157004057 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 936157004058 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157004059 dimerization interface [polypeptide binding]; other site 936157004060 Histidine kinase; Region: HisKA_3; pfam07730 936157004061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157004062 ATP binding site [chemical binding]; other site 936157004063 Mg2+ binding site [ion binding]; other site 936157004064 G-X-G motif; other site 936157004065 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 936157004066 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 936157004067 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 936157004068 [4Fe-4S] binding site [ion binding]; other site 936157004069 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157004070 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157004071 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157004072 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 936157004073 molybdopterin cofactor binding site; other site 936157004074 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 936157004075 4Fe-4S binding domain; Region: Fer4; cl02805 936157004076 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 936157004077 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 936157004078 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936157004079 Sel1-like repeats; Region: SEL1; smart00671 936157004080 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936157004081 Sel1-like repeats; Region: SEL1; smart00671 936157004082 Sel1-like repeats; Region: SEL1; smart00671 936157004083 Sel1-like repeats; Region: SEL1; smart00671 936157004084 Sel1-like repeats; Region: SEL1; smart00671 936157004085 Sel1-like repeats; Region: SEL1; smart00671 936157004086 Sel1-like repeats; Region: SEL1; smart00671 936157004087 Sel1-like repeats; Region: SEL1; smart00671 936157004088 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 936157004089 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 936157004090 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 936157004091 putative active site [active] 936157004092 putative substrate binding site [chemical binding]; other site 936157004093 putative cosubstrate binding site; other site 936157004094 catalytic site [active] 936157004095 SEC-C motif; Region: SEC-C; pfam02810 936157004096 hypothetical protein; Provisional; Region: PRK04233 936157004097 hypothetical protein; Provisional; Region: PRK10279 936157004098 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 936157004099 active site 936157004100 nucleophile elbow; other site 936157004101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157004102 active site 936157004103 response regulator of RpoS; Provisional; Region: PRK10693 936157004104 phosphorylation site [posttranslational modification] 936157004105 intermolecular recognition site; other site 936157004106 dimerization interface [polypeptide binding]; other site 936157004107 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 936157004108 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 936157004109 active site 936157004110 tetramer interface; other site 936157004111 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 936157004112 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 936157004113 thymidine kinase; Provisional; Region: PRK04296 936157004114 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 936157004115 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 936157004116 putative catalytic cysteine [active] 936157004117 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 936157004118 putative active site [active] 936157004119 metal binding site [ion binding]; metal-binding site 936157004120 hypothetical protein; Provisional; Region: PRK11111 936157004121 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 936157004122 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 936157004123 peptide binding site [polypeptide binding]; other site 936157004124 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 936157004125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157004126 dimer interface [polypeptide binding]; other site 936157004127 conserved gate region; other site 936157004128 putative PBP binding loops; other site 936157004129 ABC-ATPase subunit interface; other site 936157004130 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 936157004131 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 936157004132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157004133 dimer interface [polypeptide binding]; other site 936157004134 conserved gate region; other site 936157004135 ABC-ATPase subunit interface; other site 936157004136 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 936157004137 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936157004138 Walker A/P-loop; other site 936157004139 ATP binding site [chemical binding]; other site 936157004140 Q-loop/lid; other site 936157004141 ABC transporter signature motif; other site 936157004142 Walker B; other site 936157004143 D-loop; other site 936157004144 H-loop/switch region; other site 936157004145 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 936157004146 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 936157004147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936157004148 Walker A/P-loop; other site 936157004149 ATP binding site [chemical binding]; other site 936157004150 Q-loop/lid; other site 936157004151 ABC transporter signature motif; other site 936157004152 Walker B; other site 936157004153 D-loop; other site 936157004154 H-loop/switch region; other site 936157004155 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 936157004156 Ion transport protein; Region: Ion_trans; pfam00520 936157004157 Ion channel; Region: Ion_trans_2; pfam07885 936157004158 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 936157004159 Double zinc ribbon; Region: DZR; pfam12773 936157004160 dsDNA-mimic protein; Reviewed; Region: PRK05094 936157004161 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 936157004162 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 936157004163 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 936157004164 putative active site [active] 936157004165 catalytic site [active] 936157004166 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 936157004167 putative active site [active] 936157004168 catalytic site [active] 936157004169 YciI-like protein; Reviewed; Region: PRK11370 936157004170 transport protein TonB; Provisional; Region: PRK10819 936157004171 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 936157004172 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 936157004173 intracellular septation protein A; Reviewed; Region: PRK00259 936157004174 hypothetical protein; Provisional; Region: PRK02868 936157004175 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 936157004176 outer membrane protein W; Provisional; Region: PRK10959 936157004177 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 936157004178 dimanganese center [ion binding]; other site 936157004179 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 936157004180 dinuclear metal binding motif [ion binding]; other site 936157004181 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 936157004182 dimerization interface [polypeptide binding]; other site 936157004183 metal binding site [ion binding]; metal-binding site 936157004184 General stress protein [General function prediction only]; Region: GsiB; COG3729 936157004185 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 936157004186 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 936157004187 substrate binding site [chemical binding]; other site 936157004188 active site 936157004189 catalytic residues [active] 936157004190 heterodimer interface [polypeptide binding]; other site 936157004191 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 936157004192 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 936157004193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157004194 catalytic residue [active] 936157004195 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 936157004196 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 936157004197 active site 936157004198 ribulose/triose binding site [chemical binding]; other site 936157004199 phosphate binding site [ion binding]; other site 936157004200 substrate (anthranilate) binding pocket [chemical binding]; other site 936157004201 product (indole) binding pocket [chemical binding]; other site 936157004202 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 936157004203 active site 936157004204 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 936157004205 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 936157004206 glutamine binding [chemical binding]; other site 936157004207 catalytic triad [active] 936157004208 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 936157004209 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 936157004210 anthranilate synthase component I; Provisional; Region: PRK13564 936157004211 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 936157004212 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 936157004213 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 936157004214 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 936157004215 active site 936157004216 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 936157004217 hypothetical protein; Provisional; Region: PRK11630 936157004218 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 936157004219 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936157004220 RNA binding surface [nucleotide binding]; other site 936157004221 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 936157004222 probable active site [active] 936157004223 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 936157004224 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 936157004225 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 936157004226 homodimer interface [polypeptide binding]; other site 936157004227 Walker A motif; other site 936157004228 ATP binding site [chemical binding]; other site 936157004229 hydroxycobalamin binding site [chemical binding]; other site 936157004230 Walker B motif; other site 936157004231 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 936157004232 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 936157004233 NADP binding site [chemical binding]; other site 936157004234 homodimer interface [polypeptide binding]; other site 936157004235 active site 936157004236 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 936157004237 putative inner membrane peptidase; Provisional; Region: PRK11778 936157004238 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 936157004239 tandem repeat interface [polypeptide binding]; other site 936157004240 oligomer interface [polypeptide binding]; other site 936157004241 active site residues [active] 936157004242 hypothetical protein; Provisional; Region: PRK11037 936157004243 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 936157004244 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 936157004245 active site 936157004246 interdomain interaction site; other site 936157004247 putative metal-binding site [ion binding]; other site 936157004248 nucleotide binding site [chemical binding]; other site 936157004249 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 936157004250 domain I; other site 936157004251 DNA binding groove [nucleotide binding] 936157004252 phosphate binding site [ion binding]; other site 936157004253 domain II; other site 936157004254 domain III; other site 936157004255 nucleotide binding site [chemical binding]; other site 936157004256 catalytic site [active] 936157004257 domain IV; other site 936157004258 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 936157004259 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 936157004260 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 936157004261 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 936157004262 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 936157004263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157004264 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 936157004265 substrate binding site [chemical binding]; other site 936157004266 putative dimerization interface [polypeptide binding]; other site 936157004267 aconitate hydratase; Validated; Region: PRK09277 936157004268 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 936157004269 substrate binding site [chemical binding]; other site 936157004270 ligand binding site [chemical binding]; other site 936157004271 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 936157004272 substrate binding site [chemical binding]; other site 936157004273 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 936157004274 dimerization interface [polypeptide binding]; other site 936157004275 active site 936157004276 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 936157004277 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 936157004278 active site 936157004279 Predicted membrane protein [Function unknown]; Region: COG3771 936157004280 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 936157004281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936157004282 binding surface 936157004283 TPR motif; other site 936157004284 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 936157004285 active site 936157004286 dimer interface [polypeptide binding]; other site 936157004287 translation initiation factor Sui1; Validated; Region: PRK06824 936157004288 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 936157004289 putative rRNA binding site [nucleotide binding]; other site 936157004290 lipoprotein; Provisional; Region: PRK10540 936157004291 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936157004292 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 936157004293 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157004294 hypothetical protein; Provisional; Region: PRK13658 936157004295 RNase II stability modulator; Provisional; Region: PRK10060 936157004296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936157004297 putative active site [active] 936157004298 heme pocket [chemical binding]; other site 936157004299 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936157004300 metal binding site [ion binding]; metal-binding site 936157004301 active site 936157004302 I-site; other site 936157004303 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157004304 exoribonuclease II; Provisional; Region: PRK05054 936157004305 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 936157004306 RNB domain; Region: RNB; pfam00773 936157004307 S1 RNA binding domain; Region: S1; pfam00575 936157004308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 936157004309 Uncharacterized conserved protein [Function unknown]; Region: COG2128 936157004310 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 936157004311 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 936157004312 NAD binding site [chemical binding]; other site 936157004313 homotetramer interface [polypeptide binding]; other site 936157004314 homodimer interface [polypeptide binding]; other site 936157004315 substrate binding site [chemical binding]; other site 936157004316 active site 936157004317 Protein kinase domain; Region: Pkinase; pfam00069 936157004318 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 936157004319 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 936157004320 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936157004321 Walker A/P-loop; other site 936157004322 ATP binding site [chemical binding]; other site 936157004323 Q-loop/lid; other site 936157004324 ABC transporter signature motif; other site 936157004325 Walker B; other site 936157004326 D-loop; other site 936157004327 H-loop/switch region; other site 936157004328 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 936157004329 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936157004330 Walker A/P-loop; other site 936157004331 ATP binding site [chemical binding]; other site 936157004332 Q-loop/lid; other site 936157004333 ABC transporter signature motif; other site 936157004334 Walker B; other site 936157004335 D-loop; other site 936157004336 H-loop/switch region; other site 936157004337 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 936157004338 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 936157004339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157004340 dimer interface [polypeptide binding]; other site 936157004341 conserved gate region; other site 936157004342 putative PBP binding loops; other site 936157004343 ABC-ATPase subunit interface; other site 936157004344 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 936157004345 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 936157004346 peptide binding site [polypeptide binding]; other site 936157004347 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 936157004348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157004349 Walker A motif; other site 936157004350 ATP binding site [chemical binding]; other site 936157004351 Walker B motif; other site 936157004352 arginine finger; other site 936157004353 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 936157004354 phage shock protein PspA; Provisional; Region: PRK10698 936157004355 phage shock protein B; Provisional; Region: pspB; PRK09458 936157004356 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 936157004357 phage shock protein C; Region: phageshock_pspC; TIGR02978 936157004358 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 936157004359 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 936157004360 active site residue [active] 936157004361 YcjX-like family, DUF463; Region: DUF463; cl01193 936157004362 hypothetical protein; Provisional; Region: PRK05415 936157004363 TIGR01620 family protein; Region: hyp_HI0043 936157004364 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 936157004365 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 936157004366 putative aromatic amino acid binding site; other site 936157004367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157004368 Walker A motif; other site 936157004369 ATP binding site [chemical binding]; other site 936157004370 Walker B motif; other site 936157004371 arginine finger; other site 936157004372 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 936157004373 dimer interface [polypeptide binding]; other site 936157004374 catalytic triad [active] 936157004375 peroxidatic and resolving cysteines [active] 936157004376 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 936157004377 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 936157004378 metal binding site [ion binding]; metal-binding site 936157004379 substrate binding pocket [chemical binding]; other site 936157004380 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 936157004381 substrate binding pocket [chemical binding]; other site 936157004382 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 936157004383 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 936157004384 putative active site [active] 936157004385 Zn binding site [ion binding]; other site 936157004386 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 936157004387 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 936157004388 peptide binding site [polypeptide binding]; other site 936157004389 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 936157004390 NmrA-like family; Region: NmrA; pfam05368 936157004391 NAD(P) binding site [chemical binding]; other site 936157004392 active site lysine 936157004393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157004394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157004395 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 936157004396 putative effector binding pocket; other site 936157004397 putative dimerization interface [polypeptide binding]; other site 936157004398 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936157004399 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936157004400 active site 936157004401 catalytic tetrad [active] 936157004402 classical (c) SDRs; Region: SDR_c; cd05233 936157004403 NAD(P) binding site [chemical binding]; other site 936157004404 active site 936157004405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936157004406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157004407 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 936157004408 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 936157004409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157004410 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 936157004411 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 936157004412 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077 936157004413 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 936157004414 B3/4 domain; Region: B3_4; pfam03483 936157004415 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 936157004416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157004417 non-specific DNA binding site [nucleotide binding]; other site 936157004418 salt bridge; other site 936157004419 sequence-specific DNA binding site [nucleotide binding]; other site 936157004420 Cupin domain; Region: Cupin_2; pfam07883 936157004421 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 936157004422 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936157004423 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 936157004424 universal stress protein UspE; Provisional; Region: PRK11175 936157004425 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 936157004426 Ligand Binding Site [chemical binding]; other site 936157004427 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 936157004428 Ligand Binding Site [chemical binding]; other site 936157004429 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 936157004430 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 936157004431 ligand binding site [chemical binding]; other site 936157004432 flexible hinge region; other site 936157004433 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 936157004434 putative switch regulator; other site 936157004435 non-specific DNA interactions [nucleotide binding]; other site 936157004436 DNA binding site [nucleotide binding] 936157004437 sequence specific DNA binding site [nucleotide binding]; other site 936157004438 putative cAMP binding site [chemical binding]; other site 936157004439 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 936157004440 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 936157004441 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 936157004442 DNA binding site [nucleotide binding] 936157004443 active site 936157004444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 936157004445 Smr domain; Region: Smr; pfam01713 936157004446 HAMP domain; Region: HAMP; pfam00672 936157004447 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936157004448 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936157004449 dimer interface [polypeptide binding]; other site 936157004450 putative CheW interface [polypeptide binding]; other site 936157004451 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 936157004452 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 936157004453 Cl binding site [ion binding]; other site 936157004454 oligomer interface [polypeptide binding]; other site 936157004455 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 936157004456 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 936157004457 ATP binding site [chemical binding]; other site 936157004458 Mg++ binding site [ion binding]; other site 936157004459 motif III; other site 936157004460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157004461 nucleotide binding region [chemical binding]; other site 936157004462 ATP-binding site [chemical binding]; other site 936157004463 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 936157004464 putative RNA binding site [nucleotide binding]; other site 936157004465 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 936157004466 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 936157004467 Ligand Binding Site [chemical binding]; other site 936157004468 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 936157004469 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 936157004470 Ligand Binding Site [chemical binding]; other site 936157004471 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 936157004472 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 936157004473 dimer interface [polypeptide binding]; other site 936157004474 PYR/PP interface [polypeptide binding]; other site 936157004475 TPP binding site [chemical binding]; other site 936157004476 substrate binding site [chemical binding]; other site 936157004477 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 936157004478 Domain of unknown function; Region: EKR; smart00890 936157004479 4Fe-4S binding domain; Region: Fer4_6; pfam12837 936157004480 4Fe-4S binding domain; Region: Fer4; pfam00037 936157004481 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 936157004482 TPP-binding site [chemical binding]; other site 936157004483 dimer interface [polypeptide binding]; other site 936157004484 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 936157004485 Domain of unknown function (DUF333); Region: DUF333; pfam03891 936157004486 heat-inducible protein; Provisional; Region: PRK10449 936157004487 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 936157004488 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 936157004489 putative ligand binding site [chemical binding]; other site 936157004490 putative NAD binding site [chemical binding]; other site 936157004491 catalytic site [active] 936157004492 hypothetical protein; Provisional; Region: PRK10695 936157004493 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 936157004494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 936157004495 Uncharacterized conserved protein [Function unknown]; Region: COG3791 936157004496 azoreductase; Reviewed; Region: PRK00170 936157004497 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 936157004498 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 936157004499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936157004500 ATP binding site [chemical binding]; other site 936157004501 putative Mg++ binding site [ion binding]; other site 936157004502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157004503 nucleotide binding region [chemical binding]; other site 936157004504 ATP-binding site [chemical binding]; other site 936157004505 Helicase associated domain (HA2); Region: HA2; pfam04408 936157004506 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 936157004507 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 936157004508 Uncharacterized conserved protein [Function unknown]; Region: COG1434 936157004509 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 936157004510 putative active site [active] 936157004511 cytochrome b561; Provisional; Region: PRK11513 936157004512 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 936157004513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157004514 S-adenosylmethionine binding site [chemical binding]; other site 936157004515 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 936157004516 Predicted membrane protein [Function unknown]; Region: COG3326 936157004517 Sif protein; Region: Sif; cl11505 936157004518 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 936157004519 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 936157004520 active site 936157004521 catalytic triad [active] 936157004522 oxyanion hole [active] 936157004523 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 936157004524 putative metal binding site [ion binding]; other site 936157004525 putative homodimer interface [polypeptide binding]; other site 936157004526 putative homotetramer interface [polypeptide binding]; other site 936157004527 putative homodimer-homodimer interface [polypeptide binding]; other site 936157004528 putative allosteric switch controlling residues; other site 936157004529 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 936157004530 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 936157004531 substrate binding site [chemical binding]; other site 936157004532 catalytic Zn binding site [ion binding]; other site 936157004533 NAD binding site [chemical binding]; other site 936157004534 structural Zn binding site [ion binding]; other site 936157004535 dimer interface [polypeptide binding]; other site 936157004536 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 936157004537 dimer interface [polypeptide binding]; other site 936157004538 ligand binding site [chemical binding]; other site 936157004539 HAMP domain; Region: HAMP; pfam00672 936157004540 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936157004541 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 936157004542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157004543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 936157004544 dimerization interface [polypeptide binding]; other site 936157004545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 936157004546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 936157004547 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 936157004548 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 936157004549 substrate binding pocket [chemical binding]; other site 936157004550 catalytic triad [active] 936157004551 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 936157004552 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 936157004553 Uncharacterized conserved protein [Function unknown]; Region: COG2353 936157004554 Transcriptional regulators [Transcription]; Region: FadR; COG2186 936157004555 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157004556 DNA-binding site [nucleotide binding]; DNA binding site 936157004557 FCD domain; Region: FCD; pfam07729 936157004558 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 936157004559 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 936157004560 putative NAD(P) binding site [chemical binding]; other site 936157004561 catalytic Zn binding site [ion binding]; other site 936157004562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157004563 D-galactonate transporter; Region: 2A0114; TIGR00893 936157004564 putative substrate translocation pore; other site 936157004565 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 936157004566 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 936157004567 NADP binding site [chemical binding]; other site 936157004568 homodimer interface [polypeptide binding]; other site 936157004569 active site 936157004570 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 936157004571 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 936157004572 metal binding site [ion binding]; metal-binding site 936157004573 substrate binding pocket [chemical binding]; other site 936157004574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 936157004575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157004576 Coenzyme A binding pocket [chemical binding]; other site 936157004577 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936157004578 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 936157004579 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157004580 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 936157004581 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 936157004582 substrate binding site [chemical binding]; other site 936157004583 hexamer interface [polypeptide binding]; other site 936157004584 metal binding site [ion binding]; metal-binding site 936157004585 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936157004586 active site 936157004587 phosphorylation site [posttranslational modification] 936157004588 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 936157004589 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 936157004590 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 936157004591 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 936157004592 active site 936157004593 P-loop; other site 936157004594 phosphorylation site [posttranslational modification] 936157004595 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 936157004596 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 936157004597 oligomer interface [polypeptide binding]; other site 936157004598 active site 936157004599 metal binding site [ion binding]; metal-binding site 936157004600 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 936157004601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157004602 Coenzyme A binding pocket [chemical binding]; other site 936157004603 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 936157004604 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 936157004605 putative trimer interface [polypeptide binding]; other site 936157004606 putative CoA binding site [chemical binding]; other site 936157004607 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 936157004608 putative trimer interface [polypeptide binding]; other site 936157004609 putative CoA binding site [chemical binding]; other site 936157004610 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 936157004611 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 936157004612 gating phenylalanine in ion channel; other site 936157004613 tellurite resistance protein TehB; Provisional; Region: PRK11207 936157004614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157004615 S-adenosylmethionine binding site [chemical binding]; other site 936157004616 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 936157004617 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 936157004618 benzoate transporter; Region: benE; TIGR00843 936157004619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936157004620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157004621 non-specific DNA binding site [nucleotide binding]; other site 936157004622 salt bridge; other site 936157004623 sequence-specific DNA binding site [nucleotide binding]; other site 936157004624 Cupin domain; Region: Cupin_2; pfam07883 936157004625 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 936157004626 Peptidase family U32; Region: Peptidase_U32; pfam01136 936157004627 Collagenase; Region: DUF3656; pfam12392 936157004628 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 936157004629 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 936157004630 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 936157004631 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 936157004632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157004633 DNA-binding site [nucleotide binding]; DNA binding site 936157004634 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936157004635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157004636 homodimer interface [polypeptide binding]; other site 936157004637 catalytic residue [active] 936157004638 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 936157004639 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 936157004640 tetrameric interface [polypeptide binding]; other site 936157004641 NAD binding site [chemical binding]; other site 936157004642 catalytic residues [active] 936157004643 substrate binding site [chemical binding]; other site 936157004644 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 936157004645 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 936157004646 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 936157004647 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 936157004648 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 936157004649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 936157004650 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 936157004651 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 936157004652 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 936157004653 Prostaglandin dehydrogenases; Region: PGDH; cd05288 936157004654 NAD(P) binding site [chemical binding]; other site 936157004655 substrate binding site [chemical binding]; other site 936157004656 dimer interface [polypeptide binding]; other site 936157004657 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 936157004658 DNA-binding site [nucleotide binding]; DNA binding site 936157004659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 936157004660 FCD domain; Region: FCD; pfam07729 936157004661 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 936157004662 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 936157004663 N-terminal plug; other site 936157004664 ligand-binding site [chemical binding]; other site 936157004665 Uncharacterized conserved protein [Function unknown]; Region: COG3391 936157004666 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 936157004667 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 936157004668 L-asparagine permease; Provisional; Region: PRK15049 936157004669 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 936157004670 hypothetical protein; Provisional; Region: PRK10281 936157004671 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 936157004672 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 936157004673 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 936157004674 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 936157004675 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 936157004676 [4Fe-4S] binding site [ion binding]; other site 936157004677 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157004678 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157004679 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157004680 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 936157004681 molybdopterin cofactor binding site; other site 936157004682 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 936157004683 TetR family transcriptional regulator; Provisional; Region: PRK14996 936157004684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157004685 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 936157004686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157004687 putative substrate translocation pore; other site 936157004688 Uncharacterized conserved protein [Function unknown]; Region: COG3791 936157004689 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 936157004690 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 936157004691 trimer interface [polypeptide binding]; other site 936157004692 eyelet of channel; other site 936157004693 aromatic amino acid exporter; Provisional; Region: PRK11689 936157004694 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157004695 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157004696 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157004697 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 936157004698 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 936157004699 molybdopterin cofactor binding site; other site 936157004700 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 936157004701 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 936157004702 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 936157004703 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 936157004704 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 936157004705 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 936157004706 NAD binding site [chemical binding]; other site 936157004707 substrate binding site [chemical binding]; other site 936157004708 catalytic Zn binding site [ion binding]; other site 936157004709 tetramer interface [polypeptide binding]; other site 936157004710 structural Zn binding site [ion binding]; other site 936157004711 malate dehydrogenase; Provisional; Region: PRK13529 936157004712 Malic enzyme, N-terminal domain; Region: malic; pfam00390 936157004713 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 936157004714 NAD(P) binding site [chemical binding]; other site 936157004715 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 936157004716 biofilm-dependent modulation protein; Provisional; Region: PRK11436 936157004717 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 936157004718 acid-resistance protein; Provisional; Region: hdeB; PRK11566 936157004719 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 936157004720 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 936157004721 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 936157004722 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 936157004723 catalytic site [active] 936157004724 active site 936157004725 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 936157004726 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 936157004727 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 936157004728 active site 936157004729 catalytic site [active] 936157004730 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 936157004731 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 936157004732 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 936157004733 active site 936157004734 catalytic site [active] 936157004735 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 936157004736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936157004737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157004738 homodimer interface [polypeptide binding]; other site 936157004739 catalytic residue [active] 936157004740 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 936157004741 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936157004742 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157004743 DNA binding site [nucleotide binding] 936157004744 domain linker motif; other site 936157004745 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 936157004746 dimerization interface (closed form) [polypeptide binding]; other site 936157004747 ligand binding site [chemical binding]; other site 936157004748 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 936157004749 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 936157004750 Transcriptional regulators [Transcription]; Region: MarR; COG1846 936157004751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936157004752 putative DNA binding site [nucleotide binding]; other site 936157004753 putative Zn2+ binding site [ion binding]; other site 936157004754 hypothetical protein; Provisional; Region: PRK06184 936157004755 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 936157004756 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 936157004757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157004758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936157004759 putative substrate translocation pore; other site 936157004760 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 936157004761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157004762 D-galactonate transporter; Region: 2A0114; TIGR00893 936157004763 putative substrate translocation pore; other site 936157004764 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 936157004765 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 936157004766 putative NAD(P) binding site [chemical binding]; other site 936157004767 catalytic Zn binding site [ion binding]; other site 936157004768 structural Zn binding site [ion binding]; other site 936157004769 Transcriptional regulators [Transcription]; Region: FadR; COG2186 936157004770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157004771 DNA-binding site [nucleotide binding]; DNA binding site 936157004772 FCD domain; Region: FCD; pfam07729 936157004773 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 936157004774 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 936157004775 active site 936157004776 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 936157004777 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 936157004778 hydrogenase 1 large subunit; Provisional; Region: PRK10170 936157004779 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 936157004780 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 936157004781 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 936157004782 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 936157004783 putative substrate-binding site; other site 936157004784 nickel binding site [ion binding]; other site 936157004785 HupF/HypC family; Region: HupF_HypC; cl00394 936157004786 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 936157004787 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 936157004788 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 936157004789 Rubredoxin [Energy production and conversion]; Region: COG1773 936157004790 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 936157004791 iron binding site [ion binding]; other site 936157004792 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 936157004793 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 936157004794 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 936157004795 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 936157004796 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 936157004797 trimer interface [polypeptide binding]; other site 936157004798 eyelet of channel; other site 936157004799 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 936157004800 Predicted membrane protein [Function unknown]; Region: COG3781 936157004801 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 936157004802 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 936157004803 glutaminase; Provisional; Region: PRK00971 936157004804 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 936157004805 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 936157004806 NAD(P) binding site [chemical binding]; other site 936157004807 catalytic residues [active] 936157004808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157004809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157004810 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 936157004811 putative dimerization interface [polypeptide binding]; other site 936157004812 putative arabinose transporter; Provisional; Region: PRK03545 936157004813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157004814 putative substrate translocation pore; other site 936157004815 inner membrane protein; Provisional; Region: PRK10995 936157004816 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 936157004817 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936157004818 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 936157004819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157004820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157004821 MarB protein; Region: MarB; pfam13999 936157004822 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 936157004823 EamA-like transporter family; Region: EamA; pfam00892 936157004824 putative transporter; Provisional; Region: PRK10054 936157004825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157004826 putative substrate translocation pore; other site 936157004827 hypothetical protein; Provisional; Region: PRK10053 936157004828 hypothetical protein; Validated; Region: PRK03657 936157004829 General stress protein [General function prediction only]; Region: GsiB; COG3729 936157004830 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 936157004831 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 936157004832 active site 936157004833 Zn binding site [ion binding]; other site 936157004834 malonic semialdehyde reductase; Provisional; Region: PRK10538 936157004835 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 936157004836 putative NAD(P) binding site [chemical binding]; other site 936157004837 homodimer interface [polypeptide binding]; other site 936157004838 homotetramer interface [polypeptide binding]; other site 936157004839 active site 936157004840 Transcriptional regulators [Transcription]; Region: GntR; COG1802 936157004841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157004842 DNA-binding site [nucleotide binding]; DNA binding site 936157004843 FCD domain; Region: FCD; pfam07729 936157004844 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 936157004845 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 936157004846 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 936157004847 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 936157004848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157004849 metabolite-proton symporter; Region: 2A0106; TIGR00883 936157004850 putative substrate translocation pore; other site 936157004851 putative oxidoreductase; Provisional; Region: PRK10083 936157004852 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 936157004853 putative NAD(P) binding site [chemical binding]; other site 936157004854 catalytic Zn binding site [ion binding]; other site 936157004855 structural Zn binding site [ion binding]; other site 936157004856 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 936157004857 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 936157004858 putative active site pocket [active] 936157004859 putative metal binding site [ion binding]; other site 936157004860 hypothetical protein; Provisional; Region: PRK02237 936157004861 hypothetical protein; Provisional; Region: PRK13659 936157004862 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 936157004863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157004864 Coenzyme A binding pocket [chemical binding]; other site 936157004865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 936157004866 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 936157004867 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 936157004868 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 936157004869 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 936157004870 putative [Fe4-S4] binding site [ion binding]; other site 936157004871 putative molybdopterin cofactor binding site [chemical binding]; other site 936157004872 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 936157004873 putative molybdopterin cofactor binding site; other site 936157004874 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 936157004875 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 936157004876 putative [Fe4-S4] binding site [ion binding]; other site 936157004877 putative molybdopterin cofactor binding site [chemical binding]; other site 936157004878 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 936157004879 putative molybdopterin cofactor binding site; other site 936157004880 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 936157004881 4Fe-4S binding domain; Region: Fer4; pfam00037 936157004882 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 936157004883 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 936157004884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157004885 dimer interface [polypeptide binding]; other site 936157004886 conserved gate region; other site 936157004887 putative PBP binding loops; other site 936157004888 ABC-ATPase subunit interface; other site 936157004889 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 936157004890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157004891 dimer interface [polypeptide binding]; other site 936157004892 conserved gate region; other site 936157004893 ABC-ATPase subunit interface; other site 936157004894 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 936157004895 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 936157004896 Walker A/P-loop; other site 936157004897 ATP binding site [chemical binding]; other site 936157004898 Q-loop/lid; other site 936157004899 ABC transporter signature motif; other site 936157004900 Walker B; other site 936157004901 D-loop; other site 936157004902 H-loop/switch region; other site 936157004903 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 936157004904 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 936157004905 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 936157004906 Cl- selectivity filter; other site 936157004907 Cl- binding residues [ion binding]; other site 936157004908 pore gating glutamate residue; other site 936157004909 dimer interface [polypeptide binding]; other site 936157004910 putative dithiobiotin synthetase; Provisional; Region: PRK12374 936157004911 AAA domain; Region: AAA_26; pfam13500 936157004912 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 936157004913 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 936157004914 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936157004915 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 936157004916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157004917 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 936157004918 dimerization interface [polypeptide binding]; other site 936157004919 substrate binding pocket [chemical binding]; other site 936157004920 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936157004921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157004922 putative substrate translocation pore; other site 936157004923 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 936157004924 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 936157004925 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 936157004926 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 936157004927 Domain of unknown function DUF20; Region: UPF0118; pfam01594 936157004928 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 936157004929 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 936157004930 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 936157004931 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 936157004932 ligand binding site [chemical binding]; other site 936157004933 homodimer interface [polypeptide binding]; other site 936157004934 NAD(P) binding site [chemical binding]; other site 936157004935 trimer interface B [polypeptide binding]; other site 936157004936 trimer interface A [polypeptide binding]; other site 936157004937 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 936157004938 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 936157004939 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 936157004940 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 936157004941 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 936157004942 Spore germination protein; Region: Spore_permease; cl17796 936157004943 GlpM protein; Region: GlpM; pfam06942 936157004944 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 936157004945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157004946 active site 936157004947 phosphorylation site [posttranslational modification] 936157004948 intermolecular recognition site; other site 936157004949 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157004950 DNA binding site [nucleotide binding] 936157004951 Domain of unknown function (DUF1744); Region: DUF1744; pfam08490 936157004952 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 936157004953 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 936157004954 trimer interface [polypeptide binding]; other site 936157004955 eyelet of channel; other site 936157004956 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 936157004957 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 936157004958 active site 936157004959 sensor protein RstB; Provisional; Region: PRK10604 936157004960 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157004961 dimerization interface [polypeptide binding]; other site 936157004962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157004963 dimer interface [polypeptide binding]; other site 936157004964 phosphorylation site [posttranslational modification] 936157004965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157004966 ATP binding site [chemical binding]; other site 936157004967 Mg2+ binding site [ion binding]; other site 936157004968 G-X-G motif; other site 936157004969 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 936157004970 fumarate hydratase; Reviewed; Region: fumC; PRK00485 936157004971 Class II fumarases; Region: Fumarase_classII; cd01362 936157004972 active site 936157004973 tetramer interface [polypeptide binding]; other site 936157004974 fumarate hydratase; Provisional; Region: PRK15389 936157004975 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 936157004976 Fumarase C-terminus; Region: Fumerase_C; pfam05683 936157004977 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 936157004978 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 936157004979 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 936157004980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 936157004981 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 936157004982 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 936157004983 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 936157004984 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 936157004985 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 936157004986 active site 936157004987 purine riboside binding site [chemical binding]; other site 936157004988 putative oxidoreductase; Provisional; Region: PRK11579 936157004989 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936157004990 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936157004991 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 936157004992 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 936157004993 electron transport complex protein RsxA; Provisional; Region: PRK05151 936157004994 electron transport complex protein RnfB; Provisional; Region: PRK05113 936157004995 Putative Fe-S cluster; Region: FeS; cl17515 936157004996 4Fe-4S binding domain; Region: Fer4; pfam00037 936157004997 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 936157004998 SLBB domain; Region: SLBB; pfam10531 936157004999 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936157005000 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 936157005001 electron transport complex protein RnfG; Validated; Region: PRK01908 936157005002 electron transport complex RsxE subunit; Provisional; Region: PRK12405 936157005003 endonuclease III; Provisional; Region: PRK10702 936157005004 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 936157005005 minor groove reading motif; other site 936157005006 helix-hairpin-helix signature motif; other site 936157005007 substrate binding pocket [chemical binding]; other site 936157005008 active site 936157005009 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 936157005010 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 936157005011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157005012 putative substrate translocation pore; other site 936157005013 POT family; Region: PTR2; pfam00854 936157005014 glutathionine S-transferase; Provisional; Region: PRK10542 936157005015 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 936157005016 C-terminal domain interface [polypeptide binding]; other site 936157005017 GSH binding site (G-site) [chemical binding]; other site 936157005018 dimer interface [polypeptide binding]; other site 936157005019 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 936157005020 dimer interface [polypeptide binding]; other site 936157005021 N-terminal domain interface [polypeptide binding]; other site 936157005022 substrate binding pocket (H-site) [chemical binding]; other site 936157005023 pyridoxamine kinase; Validated; Region: PRK05756 936157005024 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 936157005025 dimer interface [polypeptide binding]; other site 936157005026 pyridoxal binding site [chemical binding]; other site 936157005027 ATP binding site [chemical binding]; other site 936157005028 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 936157005029 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 936157005030 active site 936157005031 HIGH motif; other site 936157005032 dimer interface [polypeptide binding]; other site 936157005033 KMSKS motif; other site 936157005034 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936157005035 RNA binding surface [nucleotide binding]; other site 936157005036 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 936157005037 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 936157005038 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 936157005039 lysozyme inhibitor; Provisional; Region: PRK11372 936157005040 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 936157005041 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 936157005042 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 936157005043 transcriptional regulator SlyA; Provisional; Region: PRK03573 936157005044 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 936157005045 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 936157005046 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936157005047 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157005048 Fusaric acid resistance protein family; Region: FUSC; pfam04632 936157005049 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 936157005050 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 936157005051 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 936157005052 E-class dimer interface [polypeptide binding]; other site 936157005053 P-class dimer interface [polypeptide binding]; other site 936157005054 active site 936157005055 Cu2+ binding site [ion binding]; other site 936157005056 Zn2+ binding site [ion binding]; other site 936157005057 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936157005058 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936157005059 active site 936157005060 catalytic tetrad [active] 936157005061 Predicted Fe-S protein [General function prediction only]; Region: COG3313 936157005062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936157005063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157005064 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 936157005065 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 936157005066 FMN binding site [chemical binding]; other site 936157005067 active site 936157005068 substrate binding site [chemical binding]; other site 936157005069 catalytic residue [active] 936157005070 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936157005071 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 936157005072 dimer interface [polypeptide binding]; other site 936157005073 active site 936157005074 metal binding site [ion binding]; metal-binding site 936157005075 glutathione binding site [chemical binding]; other site 936157005076 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 936157005077 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 936157005078 dimer interface [polypeptide binding]; other site 936157005079 catalytic site [active] 936157005080 putative active site [active] 936157005081 putative substrate binding site [chemical binding]; other site 936157005082 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 936157005083 putative GSH binding site [chemical binding]; other site 936157005084 catalytic residues [active] 936157005085 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 936157005086 NlpC/P60 family; Region: NLPC_P60; pfam00877 936157005087 superoxide dismutase; Provisional; Region: PRK10543 936157005088 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 936157005089 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 936157005090 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 936157005091 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157005092 DNA binding site [nucleotide binding] 936157005093 domain linker motif; other site 936157005094 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 936157005095 dimerization interface [polypeptide binding]; other site 936157005096 ligand binding site [chemical binding]; other site 936157005097 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 936157005098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157005099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 936157005100 dimerization interface [polypeptide binding]; other site 936157005101 putative transporter; Provisional; Region: PRK11043 936157005102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157005103 putative substrate translocation pore; other site 936157005104 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 936157005105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157005106 S-adenosylmethionine binding site [chemical binding]; other site 936157005107 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 936157005108 Lumazine binding domain; Region: Lum_binding; pfam00677 936157005109 Lumazine binding domain; Region: Lum_binding; pfam00677 936157005110 multidrug efflux protein; Reviewed; Region: PRK01766 936157005111 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 936157005112 cation binding site [ion binding]; other site 936157005113 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 936157005114 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 936157005115 type III secretion system protein SsaT; Provisional; Region: PRK15349 936157005116 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 936157005117 type III secretion system protein SsaQ; Validated; Region: PRK08035 936157005118 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 936157005119 type III secretion system protein SsaP; Provisional; Region: PRK15351 936157005120 type III secretion system protein SsaO; Provisional; Region: PRK15352 936157005121 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 936157005122 FHIPEP family; Region: FHIPEP; pfam00771 936157005123 type III secretion system protein SsaM; Provisional; Region: PRK15353 936157005124 type III secretion system protein SsaL; Provisional; Region: PRK15345 936157005125 HrpJ-like domain; Region: HrpJ; pfam07201 936157005126 TyeA; Region: TyeA; cl07611 936157005127 type III secretion system protein SsaK; Provisional; Region: PRK15354 936157005128 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 936157005129 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 936157005130 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 936157005131 type III secretion system protein SsaI; Provisional; Region: PRK15355 936157005132 type III secretion system protein SsaH; Provisional; Region: PRK15356 936157005133 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 936157005134 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 936157005135 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 936157005136 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 936157005137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936157005138 TPR motif; other site 936157005139 binding surface 936157005140 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 936157005141 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 936157005142 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 936157005143 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 936157005144 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 936157005145 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 936157005146 type III secretion system protein SsaD; Provisional; Region: PRK15367 936157005147 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 936157005148 outer membrane secretin SsaC; Provisional; Region: PRK15346 936157005149 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 936157005150 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 936157005151 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 936157005152 two component system sensor kinase SsrA; Provisional; Region: PRK15347 936157005153 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157005154 dimerization interface [polypeptide binding]; other site 936157005155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157005156 dimer interface [polypeptide binding]; other site 936157005157 phosphorylation site [posttranslational modification] 936157005158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157005159 ATP binding site [chemical binding]; other site 936157005160 Mg2+ binding site [ion binding]; other site 936157005161 G-X-G motif; other site 936157005162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157005163 active site 936157005164 phosphorylation site [posttranslational modification] 936157005165 intermolecular recognition site; other site 936157005166 dimerization interface [polypeptide binding]; other site 936157005167 two component system sensor kinase SsrB; Provisional; Region: PRK15369 936157005168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157005169 active site 936157005170 phosphorylation site [posttranslational modification] 936157005171 intermolecular recognition site; other site 936157005172 dimerization interface [polypeptide binding]; other site 936157005173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157005174 DNA binding residues [nucleotide binding] 936157005175 dimerization interface [polypeptide binding]; other site 936157005176 transcriptional regulator MirA; Provisional; Region: PRK15043 936157005177 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 936157005178 DNA binding residues [nucleotide binding] 936157005179 Uncharacterized conserved protein [Function unknown]; Region: COG1683 936157005180 Uncharacterized conserved protein [Function unknown]; Region: COG3272 936157005181 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 936157005182 hypothetical protein; Provisional; Region: PRK10292 936157005183 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 936157005184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157005185 active site 936157005186 phosphorylation site [posttranslational modification] 936157005187 intermolecular recognition site; other site 936157005188 dimerization interface [polypeptide binding]; other site 936157005189 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157005190 DNA binding residues [nucleotide binding] 936157005191 dimerization interface [polypeptide binding]; other site 936157005192 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 936157005193 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 936157005194 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936157005195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157005196 dimer interface [polypeptide binding]; other site 936157005197 phosphorylation site [posttranslational modification] 936157005198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157005199 ATP binding site [chemical binding]; other site 936157005200 Mg2+ binding site [ion binding]; other site 936157005201 G-X-G motif; other site 936157005202 tetrathionate reductase subunit B; Provisional; Region: PRK14993 936157005203 4Fe-4S binding domain; Region: Fer4; pfam00037 936157005204 tetrathionate reductase subunit C; Provisional; Region: PRK14992 936157005205 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 936157005206 tetrathionate reductase subunit A; Provisional; Region: PRK14991 936157005207 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 936157005208 putative [Fe4-S4] binding site [ion binding]; other site 936157005209 putative molybdopterin cofactor binding site [chemical binding]; other site 936157005210 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 936157005211 putative molybdopterin cofactor binding site; other site 936157005212 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936157005213 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 936157005214 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936157005215 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 936157005216 substrate binding site [chemical binding]; other site 936157005217 dimer interface [polypeptide binding]; other site 936157005218 ATP binding site [chemical binding]; other site 936157005219 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 936157005220 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 936157005221 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 936157005222 pyruvate kinase; Provisional; Region: PRK09206 936157005223 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 936157005224 domain interfaces; other site 936157005225 active site 936157005226 murein lipoprotein; Provisional; Region: PRK15396 936157005227 murein lipoprotein; Provisional; Region: PRK15396 936157005228 L,D-transpeptidase; Provisional; Region: PRK10190 936157005229 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936157005230 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 936157005231 cysteine desufuration protein SufE; Provisional; Region: PRK09296 936157005232 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 936157005233 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 936157005234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936157005235 catalytic residue [active] 936157005236 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 936157005237 FeS assembly protein SufD; Region: sufD; TIGR01981 936157005238 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 936157005239 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 936157005240 Walker A/P-loop; other site 936157005241 ATP binding site [chemical binding]; other site 936157005242 Q-loop/lid; other site 936157005243 ABC transporter signature motif; other site 936157005244 Walker B; other site 936157005245 D-loop; other site 936157005246 H-loop/switch region; other site 936157005247 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 936157005248 putative ABC transporter; Region: ycf24; CHL00085 936157005249 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 936157005250 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 936157005251 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 936157005252 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 936157005253 CoenzymeA binding site [chemical binding]; other site 936157005254 subunit interaction site [polypeptide binding]; other site 936157005255 PHB binding site; other site 936157005256 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 936157005257 FAD binding domain; Region: FAD_binding_4; pfam01565 936157005258 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 936157005259 putative inner membrane protein; Provisional; Region: PRK10983 936157005260 Domain of unknown function DUF20; Region: UPF0118; pfam01594 936157005261 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 936157005262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157005263 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936157005264 putative substrate translocation pore; other site 936157005265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157005266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936157005267 putative substrate translocation pore; other site 936157005268 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 936157005269 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 936157005270 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 936157005271 shikimate binding site; other site 936157005272 NAD(P) binding site [chemical binding]; other site 936157005273 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 936157005274 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 936157005275 active site 936157005276 catalytic residue [active] 936157005277 dimer interface [polypeptide binding]; other site 936157005278 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 936157005279 Coenzyme A transferase; Region: CoA_trans; smart00882 936157005280 Coenzyme A transferase; Region: CoA_trans; cl17247 936157005281 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 936157005282 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 936157005283 active site 936157005284 Cupin domain; Region: Cupin_2; pfam07883 936157005285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936157005286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157005287 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 936157005288 Ligand binding site [chemical binding]; other site 936157005289 Electron transfer flavoprotein domain; Region: ETF; pfam01012 936157005290 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 936157005291 Electron transfer flavoprotein domain; Region: ETF; smart00893 936157005292 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 936157005293 oxidoreductase; Provisional; Region: PRK10015 936157005294 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 936157005295 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 936157005296 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 936157005297 acyl-activating enzyme (AAE) consensus motif; other site 936157005298 putative AMP binding site [chemical binding]; other site 936157005299 putative active site [active] 936157005300 putative CoA binding site [chemical binding]; other site 936157005301 phosphoenolpyruvate synthase; Validated; Region: PRK06464 936157005302 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 936157005303 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 936157005304 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 936157005305 PEP synthetase regulatory protein; Provisional; Region: PRK05339 936157005306 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 936157005307 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 936157005308 hypothetical protein; Provisional; Region: PRK10183 936157005309 Uncharacterized conserved protein [Function unknown]; Region: COG0397 936157005310 hypothetical protein; Validated; Region: PRK00029 936157005311 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 936157005312 NlpC/P60 family; Region: NLPC_P60; pfam00877 936157005313 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 936157005314 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 936157005315 Walker A/P-loop; other site 936157005316 ATP binding site [chemical binding]; other site 936157005317 Q-loop/lid; other site 936157005318 ABC transporter signature motif; other site 936157005319 Walker B; other site 936157005320 D-loop; other site 936157005321 H-loop/switch region; other site 936157005322 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 936157005323 catalytic residues [active] 936157005324 dimer interface [polypeptide binding]; other site 936157005325 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 936157005326 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936157005327 ABC-ATPase subunit interface; other site 936157005328 dimer interface [polypeptide binding]; other site 936157005329 putative PBP binding regions; other site 936157005330 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 936157005331 IHF dimer interface [polypeptide binding]; other site 936157005332 IHF - DNA interface [nucleotide binding]; other site 936157005333 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 936157005334 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 936157005335 putative tRNA-binding site [nucleotide binding]; other site 936157005336 B3/4 domain; Region: B3_4; pfam03483 936157005337 tRNA synthetase B5 domain; Region: B5; smart00874 936157005338 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 936157005339 dimer interface [polypeptide binding]; other site 936157005340 motif 1; other site 936157005341 motif 3; other site 936157005342 motif 2; other site 936157005343 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 936157005344 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 936157005345 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 936157005346 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 936157005347 dimer interface [polypeptide binding]; other site 936157005348 motif 1; other site 936157005349 active site 936157005350 motif 2; other site 936157005351 motif 3; other site 936157005352 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 936157005353 23S rRNA binding site [nucleotide binding]; other site 936157005354 L21 binding site [polypeptide binding]; other site 936157005355 L13 binding site [polypeptide binding]; other site 936157005356 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 936157005357 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 936157005358 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 936157005359 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 936157005360 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 936157005361 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 936157005362 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 936157005363 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 936157005364 active site 936157005365 dimer interface [polypeptide binding]; other site 936157005366 motif 1; other site 936157005367 motif 2; other site 936157005368 motif 3; other site 936157005369 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 936157005370 anticodon binding site; other site 936157005371 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 936157005372 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 936157005373 active site 936157005374 substrate binding site [chemical binding]; other site 936157005375 Mg2+ binding site [ion binding]; other site 936157005376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 936157005377 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 936157005378 6-phosphofructokinase 2; Provisional; Region: PRK10294 936157005379 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 936157005380 putative substrate binding site [chemical binding]; other site 936157005381 putative ATP binding site [chemical binding]; other site 936157005382 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 936157005383 Phosphotransferase enzyme family; Region: APH; pfam01636 936157005384 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 936157005385 active site 936157005386 ATP binding site [chemical binding]; other site 936157005387 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 936157005388 YniB-like protein; Region: YniB; pfam14002 936157005389 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 936157005390 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 936157005391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157005392 motif II; other site 936157005393 inner membrane protein; Provisional; Region: PRK11648 936157005394 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 936157005395 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 936157005396 cell division modulator; Provisional; Region: PRK10113 936157005397 hydroperoxidase II; Provisional; Region: katE; PRK11249 936157005398 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 936157005399 tetramer interface [polypeptide binding]; other site 936157005400 heme binding pocket [chemical binding]; other site 936157005401 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 936157005402 domain interactions; other site 936157005403 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 936157005404 putative active site [active] 936157005405 YdjC motif; other site 936157005406 Mg binding site [ion binding]; other site 936157005407 putative homodimer interface [polypeptide binding]; other site 936157005408 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 936157005409 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 936157005410 NAD binding site [chemical binding]; other site 936157005411 sugar binding site [chemical binding]; other site 936157005412 divalent metal binding site [ion binding]; other site 936157005413 tetramer (dimer of dimers) interface [polypeptide binding]; other site 936157005414 dimer interface [polypeptide binding]; other site 936157005415 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 936157005416 Cupin domain; Region: Cupin_2; pfam07883 936157005417 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157005418 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 936157005419 methionine cluster; other site 936157005420 active site 936157005421 phosphorylation site [posttranslational modification] 936157005422 metal binding site [ion binding]; metal-binding site 936157005423 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 936157005424 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 936157005425 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 936157005426 active site 936157005427 P-loop; other site 936157005428 phosphorylation site [posttranslational modification] 936157005429 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 936157005430 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 936157005431 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 936157005432 homodimer interface [polypeptide binding]; other site 936157005433 NAD binding pocket [chemical binding]; other site 936157005434 ATP binding pocket [chemical binding]; other site 936157005435 Mg binding site [ion binding]; other site 936157005436 active-site loop [active] 936157005437 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 936157005438 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 936157005439 GIY-YIG motif/motif A; other site 936157005440 active site 936157005441 catalytic site [active] 936157005442 putative DNA binding site [nucleotide binding]; other site 936157005443 metal binding site [ion binding]; metal-binding site 936157005444 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 936157005445 dimer interface [polypeptide binding]; other site 936157005446 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 936157005447 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 936157005448 putative active site [active] 936157005449 Zn binding site [ion binding]; other site 936157005450 succinylarginine dihydrolase; Provisional; Region: PRK13281 936157005451 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 936157005452 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 936157005453 NAD(P) binding site [chemical binding]; other site 936157005454 catalytic residues [active] 936157005455 arginine succinyltransferase; Provisional; Region: PRK10456 936157005456 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 936157005457 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 936157005458 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936157005459 inhibitor-cofactor binding pocket; inhibition site 936157005460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157005461 catalytic residue [active] 936157005462 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 936157005463 putative catalytic site [active] 936157005464 putative phosphate binding site [ion binding]; other site 936157005465 active site 936157005466 metal binding site A [ion binding]; metal-binding site 936157005467 DNA binding site [nucleotide binding] 936157005468 putative AP binding site [nucleotide binding]; other site 936157005469 putative metal binding site B [ion binding]; other site 936157005470 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 936157005471 active site 936157005472 8-oxo-dGMP binding site [chemical binding]; other site 936157005473 nudix motif; other site 936157005474 metal binding site [ion binding]; metal-binding site 936157005475 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 936157005476 glutamate dehydrogenase; Provisional; Region: PRK09414 936157005477 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 936157005478 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 936157005479 NAD(P) binding site [chemical binding]; other site 936157005480 DNA topoisomerase III; Provisional; Region: PRK07726 936157005481 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 936157005482 active site 936157005483 putative interdomain interaction site [polypeptide binding]; other site 936157005484 putative metal-binding site [ion binding]; other site 936157005485 putative nucleotide binding site [chemical binding]; other site 936157005486 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 936157005487 domain I; other site 936157005488 DNA binding groove [nucleotide binding] 936157005489 phosphate binding site [ion binding]; other site 936157005490 domain II; other site 936157005491 domain III; other site 936157005492 nucleotide binding site [chemical binding]; other site 936157005493 catalytic site [active] 936157005494 domain IV; other site 936157005495 selenophosphate synthetase; Provisional; Region: PRK00943 936157005496 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 936157005497 dimerization interface [polypeptide binding]; other site 936157005498 putative ATP binding site [chemical binding]; other site 936157005499 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 936157005500 putative FMN binding site [chemical binding]; other site 936157005501 protease 4; Provisional; Region: PRK10949 936157005502 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 936157005503 tandem repeat interface [polypeptide binding]; other site 936157005504 oligomer interface [polypeptide binding]; other site 936157005505 active site residues [active] 936157005506 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 936157005507 tandem repeat interface [polypeptide binding]; other site 936157005508 oligomer interface [polypeptide binding]; other site 936157005509 active site residues [active] 936157005510 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 936157005511 active site 936157005512 homodimer interface [polypeptide binding]; other site 936157005513 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 936157005514 Isochorismatase family; Region: Isochorismatase; pfam00857 936157005515 catalytic triad [active] 936157005516 metal binding site [ion binding]; metal-binding site 936157005517 conserved cis-peptide bond; other site 936157005518 benzoate transport; Region: 2A0115; TIGR00895 936157005519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157005520 putative substrate translocation pore; other site 936157005521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157005522 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936157005523 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 936157005524 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157005525 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936157005526 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936157005527 active site 936157005528 catalytic tetrad [active] 936157005529 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 936157005530 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936157005531 substrate binding site [chemical binding]; other site 936157005532 ATP binding site [chemical binding]; other site 936157005533 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 936157005534 intersubunit interface [polypeptide binding]; other site 936157005535 active site 936157005536 zinc binding site [ion binding]; other site 936157005537 Na+ binding site [ion binding]; other site 936157005538 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 936157005539 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 936157005540 inhibitor binding site; inhibition site 936157005541 catalytic Zn binding site [ion binding]; other site 936157005542 structural Zn binding site [ion binding]; other site 936157005543 NADP binding site [chemical binding]; other site 936157005544 tetramer interface [polypeptide binding]; other site 936157005545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157005546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157005547 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 936157005548 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 936157005549 putative NAD(P) binding site [chemical binding]; other site 936157005550 catalytic Zn binding site [ion binding]; other site 936157005551 structural Zn binding site [ion binding]; other site 936157005552 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 936157005553 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 936157005554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 936157005555 methionine sulfoxide reductase B; Provisional; Region: PRK00222 936157005556 SelR domain; Region: SelR; pfam01641 936157005557 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 936157005558 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 936157005559 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 936157005560 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 936157005561 active site 936157005562 phosphate binding residues; other site 936157005563 catalytic residues [active] 936157005564 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936157005565 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936157005566 active site 936157005567 catalytic tetrad [active] 936157005568 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 936157005569 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157005570 FeS/SAM binding site; other site 936157005571 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 936157005572 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 936157005573 PrkA family serine protein kinase; Provisional; Region: PRK15455 936157005574 AAA ATPase domain; Region: AAA_16; pfam13191 936157005575 Walker A motif; other site 936157005576 ATP binding site [chemical binding]; other site 936157005577 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 936157005578 hypothetical protein; Provisional; Region: PRK05325 936157005579 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 936157005580 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936157005581 metal binding site [ion binding]; metal-binding site 936157005582 active site 936157005583 I-site; other site 936157005584 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 936157005585 putative deacylase active site [active] 936157005586 Predicted membrane protein [Function unknown]; Region: COG2707 936157005587 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936157005588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157005589 cyanate transporter; Region: CynX; TIGR00896 936157005590 Uncharacterized conserved protein [Function unknown]; Region: COG3189 936157005591 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 936157005592 murein hydrolase B; Provisional; Region: PRK10760; cl17906 936157005593 Domain of unknown function (DUF333); Region: DUF333; pfam03891 936157005594 hypothetical protein; Provisional; Region: PRK10457 936157005595 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 936157005596 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 936157005597 leucine export protein LeuE; Provisional; Region: PRK10958 936157005598 chorismate mutase; Provisional; Region: PRK08055 936157005599 Pleckstrin homology-like domain; Region: PH-like; cl17171 936157005600 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 936157005601 transcriptional regulator MirA; Provisional; Region: PRK15043 936157005602 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 936157005603 DNA binding residues [nucleotide binding] 936157005604 dimer interface [polypeptide binding]; other site 936157005605 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157005606 DNA binding residues [nucleotide binding] 936157005607 aminoglycoside resistance protein; Provisional; Region: PRK13746 936157005608 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 936157005609 active site 936157005610 NTP binding site [chemical binding]; other site 936157005611 metal binding triad [ion binding]; metal-binding site 936157005612 antibiotic binding site [chemical binding]; other site 936157005613 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 936157005614 Transposase IS200 like; Region: Y1_Tnp; pfam01797 936157005615 zinc/cadmium-binding protein; Provisional; Region: PRK10306 936157005616 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 936157005617 dimerization interface [polypeptide binding]; other site 936157005618 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 936157005619 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936157005620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157005621 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 936157005622 Walker A/P-loop; other site 936157005623 ATP binding site [chemical binding]; other site 936157005624 Q-loop/lid; other site 936157005625 ABC transporter signature motif; other site 936157005626 Walker B; other site 936157005627 D-loop; other site 936157005628 H-loop/switch region; other site 936157005629 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936157005630 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 936157005631 Walker A/P-loop; other site 936157005632 ATP binding site [chemical binding]; other site 936157005633 Q-loop/lid; other site 936157005634 ABC transporter signature motif; other site 936157005635 Walker B; other site 936157005636 D-loop; other site 936157005637 H-loop/switch region; other site 936157005638 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 936157005639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157005640 dimer interface [polypeptide binding]; other site 936157005641 conserved gate region; other site 936157005642 putative PBP binding loops; other site 936157005643 ABC-ATPase subunit interface; other site 936157005644 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 936157005645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157005646 dimer interface [polypeptide binding]; other site 936157005647 conserved gate region; other site 936157005648 ABC-ATPase subunit interface; other site 936157005649 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 936157005650 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 936157005651 TRL-like protein family; Region: TRL; pfam13146 936157005652 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 936157005653 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 936157005654 BNR repeat-like domain; Region: BNR_2; pfam13088 936157005655 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 936157005656 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 936157005657 putative dimer interface [polypeptide binding]; other site 936157005658 lysozyme inhibitor; Provisional; Region: PRK13791 936157005659 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 936157005660 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 936157005661 DNA-binding site [nucleotide binding]; DNA binding site 936157005662 RNA-binding motif; other site 936157005663 Ricin-type beta-trefoil; Region: RICIN; smart00458 936157005664 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 936157005665 putative sugar binding sites [chemical binding]; other site 936157005666 Q-X-W motif; other site 936157005667 DinI-like family; Region: DinI; pfam06183 936157005668 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 936157005669 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 936157005670 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 936157005671 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 936157005672 Predicted chitinase [General function prediction only]; Region: COG3179 936157005673 catalytic residue [active] 936157005674 Protein of unknown function (DUF754); Region: DUF754; pfam05449 936157005675 Antitermination protein; Region: Antiterm; pfam03589 936157005676 Protein of unknown function (DUF1356); Region: DUF1356; pfam07092 936157005677 Antitermination protein; Region: Antiterm; pfam03589 936157005678 Protein of unknown function (DUF968); Region: DUF968; pfam06147 936157005679 KilA-N domain; Region: KilA-N; pfam04383 936157005680 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 936157005681 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 936157005682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157005683 DNA-binding site [nucleotide binding]; DNA binding site 936157005684 Ash protein family; Region: Phage_ASH; pfam10554 936157005685 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 936157005686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157005687 non-specific DNA binding site [nucleotide binding]; other site 936157005688 salt bridge; other site 936157005689 sequence-specific DNA binding site [nucleotide binding]; other site 936157005690 Predicted transcriptional regulator [Transcription]; Region: COG2932 936157005691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157005692 non-specific DNA binding site [nucleotide binding]; other site 936157005693 salt bridge; other site 936157005694 sequence-specific DNA binding site [nucleotide binding]; other site 936157005695 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 936157005696 Catalytic site [active] 936157005697 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 936157005698 HD domain; Region: HD_3; cl17350 936157005699 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 936157005700 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 936157005701 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 936157005702 dimer interface [polypeptide binding]; other site 936157005703 active site 936157005704 Int/Topo IB signature motif; other site 936157005705 isocitrate dehydrogenase; Validated; Region: PRK07362 936157005706 isocitrate dehydrogenase; Reviewed; Region: PRK07006 936157005707 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 936157005708 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 936157005709 probable active site [active] 936157005710 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 936157005711 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 936157005712 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 936157005713 nudix motif; other site 936157005714 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 936157005715 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 936157005716 putative lysogenization regulator; Reviewed; Region: PRK00218 936157005717 adenylosuccinate lyase; Provisional; Region: PRK09285 936157005718 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 936157005719 tetramer interface [polypeptide binding]; other site 936157005720 active site 936157005721 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 936157005722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157005723 active site 936157005724 phosphorylation site [posttranslational modification] 936157005725 intermolecular recognition site; other site 936157005726 dimerization interface [polypeptide binding]; other site 936157005727 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157005728 DNA binding site [nucleotide binding] 936157005729 sensor protein PhoQ; Provisional; Region: PRK10815 936157005730 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 936157005731 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 936157005732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157005733 ATP binding site [chemical binding]; other site 936157005734 Mg2+ binding site [ion binding]; other site 936157005735 G-X-G motif; other site 936157005736 Uncharacterized conserved protein [Function unknown]; Region: COG2850 936157005737 Cupin domain; Region: Cupin_2; cl17218 936157005738 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 936157005739 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 936157005740 metal binding site [ion binding]; metal-binding site 936157005741 dimer interface [polypeptide binding]; other site 936157005742 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 936157005743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157005744 Walker A/P-loop; other site 936157005745 ATP binding site [chemical binding]; other site 936157005746 Q-loop/lid; other site 936157005747 ABC transporter signature motif; other site 936157005748 Walker B; other site 936157005749 D-loop; other site 936157005750 H-loop/switch region; other site 936157005751 TOBE domain; Region: TOBE_2; pfam08402 936157005752 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 936157005753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157005754 dimer interface [polypeptide binding]; other site 936157005755 conserved gate region; other site 936157005756 putative PBP binding loops; other site 936157005757 ABC-ATPase subunit interface; other site 936157005758 secreted effector protein SifA; Reviewed; Region: sifA; PRK09498 936157005759 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 936157005760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157005761 dimer interface [polypeptide binding]; other site 936157005762 conserved gate region; other site 936157005763 putative PBP binding loops; other site 936157005764 ABC-ATPase subunit interface; other site 936157005765 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 936157005766 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 936157005767 NAD-dependent deacetylase; Provisional; Region: PRK00481 936157005768 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 936157005769 NAD+ binding site [chemical binding]; other site 936157005770 substrate binding site [chemical binding]; other site 936157005771 Zn binding site [ion binding]; other site 936157005772 fructokinase; Reviewed; Region: PRK09557 936157005773 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936157005774 nucleotide binding site [chemical binding]; other site 936157005775 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 936157005776 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 936157005777 FtsX-like permease family; Region: FtsX; pfam02687 936157005778 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 936157005779 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 936157005780 Walker A/P-loop; other site 936157005781 ATP binding site [chemical binding]; other site 936157005782 Q-loop/lid; other site 936157005783 ABC transporter signature motif; other site 936157005784 Walker B; other site 936157005785 D-loop; other site 936157005786 H-loop/switch region; other site 936157005787 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 936157005788 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 936157005789 FtsX-like permease family; Region: FtsX; pfam02687 936157005790 transcription-repair coupling factor; Provisional; Region: PRK10689 936157005791 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 936157005792 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936157005793 ATP binding site [chemical binding]; other site 936157005794 putative Mg++ binding site [ion binding]; other site 936157005795 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157005796 nucleotide binding region [chemical binding]; other site 936157005797 ATP-binding site [chemical binding]; other site 936157005798 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 936157005799 L,D-transpeptidase; Provisional; Region: PRK10260 936157005800 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936157005801 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 936157005802 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 936157005803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 936157005804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157005805 hypothetical protein; Provisional; Region: PRK11280 936157005806 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 936157005807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936157005808 hypothetical protein; Provisional; Region: PRK04940 936157005809 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 936157005810 beta-hexosaminidase; Provisional; Region: PRK05337 936157005811 thiamine kinase; Region: ycfN_thiK; TIGR02721 936157005812 thiamine kinase; Provisional; Region: thiK; PRK10271 936157005813 substrate binding site [chemical binding]; other site 936157005814 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 936157005815 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 936157005816 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 936157005817 putative dimer interface [polypeptide binding]; other site 936157005818 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 936157005819 nucleotide binding site/active site [active] 936157005820 HIT family signature motif; other site 936157005821 catalytic residue [active] 936157005822 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 936157005823 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 936157005824 N-terminal plug; other site 936157005825 ligand-binding site [chemical binding]; other site 936157005826 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 936157005827 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936157005828 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936157005829 active site turn [active] 936157005830 phosphorylation site [posttranslational modification] 936157005831 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 936157005832 active site 936157005833 DNA polymerase III subunit delta'; Validated; Region: PRK07993 936157005834 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 936157005835 thymidylate kinase; Validated; Region: tmk; PRK00698 936157005836 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 936157005837 TMP-binding site; other site 936157005838 ATP-binding site [chemical binding]; other site 936157005839 conserved hypothetical protein, YceG family; Region: TIGR00247 936157005840 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 936157005841 dimerization interface [polypeptide binding]; other site 936157005842 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 936157005843 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 936157005844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157005845 catalytic residue [active] 936157005846 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 936157005847 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 936157005848 dimer interface [polypeptide binding]; other site 936157005849 active site 936157005850 acyl carrier protein; Provisional; Region: acpP; PRK00982 936157005851 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 936157005852 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 936157005853 NAD(P) binding site [chemical binding]; other site 936157005854 homotetramer interface [polypeptide binding]; other site 936157005855 homodimer interface [polypeptide binding]; other site 936157005856 active site 936157005857 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 936157005858 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 936157005859 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 936157005860 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 936157005861 dimer interface [polypeptide binding]; other site 936157005862 active site 936157005863 CoA binding pocket [chemical binding]; other site 936157005864 putative phosphate acyltransferase; Provisional; Region: PRK05331 936157005865 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 936157005866 hypothetical protein; Provisional; Region: PRK11193 936157005867 Maf-like protein; Region: Maf; pfam02545 936157005868 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 936157005869 active site 936157005870 dimer interface [polypeptide binding]; other site 936157005871 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 936157005872 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 936157005873 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936157005874 RNA binding surface [nucleotide binding]; other site 936157005875 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 936157005876 active site 936157005877 ribonuclease E; Reviewed; Region: rne; PRK10811 936157005878 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 936157005879 homodimer interface [polypeptide binding]; other site 936157005880 oligonucleotide binding site [chemical binding]; other site 936157005881 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 936157005882 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 936157005883 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 936157005884 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 936157005885 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 936157005886 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 936157005887 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 936157005888 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 936157005889 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 936157005890 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 936157005891 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 936157005892 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 936157005893 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 936157005894 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 936157005895 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 936157005896 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 936157005897 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 936157005898 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 936157005899 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 936157005900 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 936157005901 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 936157005902 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 936157005903 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 936157005904 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 936157005905 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 936157005906 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 936157005907 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 936157005908 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 936157005909 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 936157005910 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 936157005911 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 936157005912 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 936157005913 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 936157005914 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 936157005915 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 936157005916 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 936157005917 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 936157005918 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936157005919 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936157005920 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936157005921 hypothetical protein; Provisional; Region: PRK11239 936157005922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 936157005923 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 936157005924 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 936157005925 multidrug resistance protein MdtH; Provisional; Region: PRK11646 936157005926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157005927 putative substrate translocation pore; other site 936157005928 glutaredoxin 2; Provisional; Region: PRK10387 936157005929 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 936157005930 C-terminal domain interface [polypeptide binding]; other site 936157005931 GSH binding site (G-site) [chemical binding]; other site 936157005932 catalytic residues [active] 936157005933 putative dimer interface [polypeptide binding]; other site 936157005934 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 936157005935 N-terminal domain interface [polypeptide binding]; other site 936157005936 lipoprotein; Provisional; Region: PRK10598 936157005937 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 936157005938 active site 936157005939 substrate binding pocket [chemical binding]; other site 936157005940 dimer interface [polypeptide binding]; other site 936157005941 DNA damage-inducible protein I; Provisional; Region: PRK10597 936157005942 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 936157005943 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 936157005944 hydroxyglutarate oxidase; Provisional; Region: PRK11728 936157005945 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 936157005946 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 936157005947 hypothetical protein; Provisional; Region: PRK03757 936157005948 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 936157005949 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 936157005950 active site residue [active] 936157005951 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 936157005952 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 936157005953 putative acyl-acceptor binding pocket; other site 936157005954 drug efflux system protein MdtG; Provisional; Region: PRK09874 936157005955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157005956 putative substrate translocation pore; other site 936157005957 lipoprotein; Provisional; Region: PRK10175 936157005958 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 936157005959 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 936157005960 Ligand binding site; other site 936157005961 DXD motif; other site 936157005962 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 936157005963 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 936157005964 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 936157005965 Acyltransferase family; Region: Acyl_transf_3; pfam01757 936157005966 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 936157005967 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 936157005968 putative active site [active] 936157005969 catalytic site [active] 936157005970 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 936157005971 putative active site [active] 936157005972 catalytic site [active] 936157005973 Fimbrial protein; Region: Fimbrial; cl01416 936157005974 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 936157005975 major curlin subunit; Provisional; Region: csgA; PRK10051 936157005976 Curlin associated repeat; Region: Curlin_rpt; pfam07012 936157005977 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 936157005978 Curlin associated repeat; Region: Curlin_rpt; pfam07012 936157005979 Curlin associated repeat; Region: Curlin_rpt; pfam07012 936157005980 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 936157005981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157005982 DNA binding residues [nucleotide binding] 936157005983 dimerization interface [polypeptide binding]; other site 936157005984 curli assembly protein CsgE; Provisional; Region: PRK10386 936157005985 curli assembly protein CsgF; Provisional; Region: PRK10050 936157005986 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 936157005987 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 936157005988 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 936157005989 putative hydrolase; Validated; Region: PRK09248 936157005990 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 936157005991 active site 936157005992 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 936157005993 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 936157005994 putative ligand binding site [chemical binding]; other site 936157005995 NAD binding site [chemical binding]; other site 936157005996 dimerization interface [polypeptide binding]; other site 936157005997 catalytic site [active] 936157005998 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 936157005999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936157006000 ATP binding site [chemical binding]; other site 936157006001 putative Mg++ binding site [ion binding]; other site 936157006002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157006003 nucleotide binding region [chemical binding]; other site 936157006004 ATP-binding site [chemical binding]; other site 936157006005 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 936157006006 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 936157006007 DNA-binding interface [nucleotide binding]; DNA binding site 936157006008 Transposase; Region: DEDD_Tnp_IS110; pfam01548 936157006009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 936157006010 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 936157006011 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 936157006012 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 936157006013 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 936157006014 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 936157006015 Integrase; Region: Integrase_1; pfam12835 936157006016 Predicted transcriptional regulators [Transcription]; Region: COG1733 936157006017 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 936157006018 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 936157006019 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 936157006020 AMP nucleosidase; Provisional; Region: PRK08292 936157006021 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 936157006022 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 936157006023 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 936157006024 MATE family multidrug exporter; Provisional; Region: PRK10189 936157006025 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 936157006026 L,D-transpeptidase; Provisional; Region: PRK10190 936157006027 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 936157006028 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 936157006029 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 936157006030 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 936157006031 putative dimer interface [polypeptide binding]; other site 936157006032 active site pocket [active] 936157006033 putative cataytic base [active] 936157006034 cobalamin synthase; Reviewed; Region: cobS; PRK00235 936157006035 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 936157006036 homotrimer interface [polypeptide binding]; other site 936157006037 Walker A motif; other site 936157006038 GTP binding site [chemical binding]; other site 936157006039 Walker B motif; other site 936157006040 cobyric acid synthase; Provisional; Region: PRK00784 936157006041 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 936157006042 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 936157006043 catalytic triad [active] 936157006044 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 936157006045 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 936157006046 Walker A/P-loop; other site 936157006047 ATP binding site [chemical binding]; other site 936157006048 Q-loop/lid; other site 936157006049 ABC transporter signature motif; other site 936157006050 Walker B; other site 936157006051 D-loop; other site 936157006052 H-loop/switch region; other site 936157006053 cobalt transport protein CbiQ; Provisional; Region: PRK15485 936157006054 cobalt transport protein CbiN; Provisional; Region: PRK02898 936157006055 cobalt transport protein CbiM; Validated; Region: PRK08319 936157006056 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 936157006057 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 936157006058 active site 936157006059 SAM binding site [chemical binding]; other site 936157006060 homodimer interface [polypeptide binding]; other site 936157006061 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 936157006062 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 936157006063 active site 936157006064 C-terminal domain interface [polypeptide binding]; other site 936157006065 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 936157006066 active site 936157006067 N-terminal domain interface [polypeptide binding]; other site 936157006068 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 936157006069 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 936157006070 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 936157006071 active site 936157006072 SAM binding site [chemical binding]; other site 936157006073 homodimer interface [polypeptide binding]; other site 936157006074 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 936157006075 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 936157006076 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 936157006077 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 936157006078 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 936157006079 active site 936157006080 SAM binding site [chemical binding]; other site 936157006081 homodimer interface [polypeptide binding]; other site 936157006082 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 936157006083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157006084 S-adenosylmethionine binding site [chemical binding]; other site 936157006085 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 936157006086 active site 936157006087 putative homodimer interface [polypeptide binding]; other site 936157006088 SAM binding site [chemical binding]; other site 936157006089 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 936157006090 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 936157006091 Precorrin-8X methylmutase; Region: CbiC; pfam02570 936157006092 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 936157006093 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 936157006094 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 936157006095 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 936157006096 catalytic triad [active] 936157006097 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 936157006098 Sensory domain found in PocR; Region: PocR; pfam10114 936157006099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157006100 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936157006101 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157006102 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 936157006103 amphipathic channel; other site 936157006104 Asn-Pro-Ala signature motifs; other site 936157006105 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 936157006106 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 936157006107 Hexamer interface [polypeptide binding]; other site 936157006108 Putative hexagonal pore residue; other site 936157006109 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 936157006110 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 936157006111 putative hexamer interface [polypeptide binding]; other site 936157006112 putative hexagonal pore; other site 936157006113 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 936157006114 putative hexamer interface [polypeptide binding]; other site 936157006115 putative hexagonal pore; other site 936157006116 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 936157006117 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 936157006118 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 936157006119 alpha-beta subunit interface [polypeptide binding]; other site 936157006120 alpha-gamma subunit interface [polypeptide binding]; other site 936157006121 active site 936157006122 substrate and K+ binding site; other site 936157006123 K+ binding site [ion binding]; other site 936157006124 cobalamin binding site [chemical binding]; other site 936157006125 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 936157006126 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 936157006127 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 936157006128 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 936157006129 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 936157006130 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 936157006131 Hexamer interface [polypeptide binding]; other site 936157006132 Putative hexagonal pore residue; other site 936157006133 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 936157006134 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 936157006135 putative hexamer interface [polypeptide binding]; other site 936157006136 putative hexagonal pore; other site 936157006137 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 936157006138 Propanediol utilisation protein PduL; Region: PduL; pfam06130 936157006139 Propanediol utilisation protein PduL; Region: PduL; pfam06130 936157006140 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 936157006141 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 936157006142 Hexamer/Pentamer interface [polypeptide binding]; other site 936157006143 central pore; other site 936157006144 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 936157006145 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 936157006146 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 936157006147 putative catalytic cysteine [active] 936157006148 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 936157006149 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 936157006150 putative active site [active] 936157006151 metal binding site [ion binding]; metal-binding site 936157006152 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 936157006153 SLBB domain; Region: SLBB; pfam10531 936157006154 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 936157006155 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 936157006156 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 936157006157 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 936157006158 putative hexamer interface [polypeptide binding]; other site 936157006159 putative hexagonal pore; other site 936157006160 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 936157006161 putative hexamer interface [polypeptide binding]; other site 936157006162 putative hexagonal pore; other site 936157006163 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 936157006164 putative hexamer interface [polypeptide binding]; other site 936157006165 putative hexagonal pore; other site 936157006166 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 936157006167 G3 box; other site 936157006168 Switch II region; other site 936157006169 GTP/Mg2+ binding site [chemical binding]; other site 936157006170 G4 box; other site 936157006171 G5 box; other site 936157006172 propionate kinase; Reviewed; Region: PRK12397 936157006173 propionate/acetate kinase; Provisional; Region: PRK12379 936157006174 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 936157006175 hypothetical protein; Provisional; Region: PRK05423 936157006176 Predicted membrane protein [Function unknown]; Region: COG1289 936157006177 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 936157006178 DNA gyrase inhibitor; Provisional; Region: PRK10016 936157006179 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 936157006180 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 936157006181 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 936157006182 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 936157006183 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 936157006184 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 936157006185 4Fe-4S binding domain; Region: Fer4; cl02805 936157006186 thiosulfate reductase PhsA; Provisional; Region: PRK15488 936157006187 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 936157006188 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 936157006189 putative [Fe4-S4] binding site [ion binding]; other site 936157006190 putative molybdopterin cofactor binding site [chemical binding]; other site 936157006191 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157006192 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 936157006193 putative molybdopterin cofactor binding site; other site 936157006194 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 936157006195 SopA-like central domain; Region: SopA; pfam13981 936157006196 SopA-like catalytic domain; Region: SopA_C; pfam13979 936157006197 exonuclease I; Provisional; Region: sbcB; PRK11779 936157006198 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 936157006199 active site 936157006200 catalytic site [active] 936157006201 substrate binding site [chemical binding]; other site 936157006202 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 936157006203 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 936157006204 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 936157006205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157006206 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 936157006207 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 936157006208 dimerization interface [polypeptide binding]; other site 936157006209 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 936157006210 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 936157006211 putative NAD(P) binding site [chemical binding]; other site 936157006212 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 936157006213 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 936157006214 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 936157006215 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 936157006216 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 936157006217 NAD binding site [chemical binding]; other site 936157006218 dimerization interface [polypeptide binding]; other site 936157006219 product binding site; other site 936157006220 substrate binding site [chemical binding]; other site 936157006221 zinc binding site [ion binding]; other site 936157006222 catalytic residues [active] 936157006223 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 936157006224 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936157006225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157006226 homodimer interface [polypeptide binding]; other site 936157006227 catalytic residue [active] 936157006228 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 936157006229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157006230 active site 936157006231 motif I; other site 936157006232 motif II; other site 936157006233 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 936157006234 putative active site pocket [active] 936157006235 4-fold oligomerization interface [polypeptide binding]; other site 936157006236 metal binding residues [ion binding]; metal-binding site 936157006237 3-fold/trimer interface [polypeptide binding]; other site 936157006238 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 936157006239 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 936157006240 putative active site [active] 936157006241 oxyanion strand; other site 936157006242 catalytic triad [active] 936157006243 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 936157006244 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 936157006245 catalytic residues [active] 936157006246 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 936157006247 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 936157006248 substrate binding site [chemical binding]; other site 936157006249 glutamase interaction surface [polypeptide binding]; other site 936157006250 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 936157006251 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 936157006252 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 936157006253 metal binding site [ion binding]; metal-binding site 936157006254 chain length determinant protein WzzB; Provisional; Region: PRK15471 936157006255 Chain length determinant protein; Region: Wzz; cl15801 936157006256 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 936157006257 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 936157006258 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 936157006259 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 936157006260 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 936157006261 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 936157006262 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 936157006263 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 936157006264 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 936157006265 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 936157006266 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 936157006267 Bacterial sugar transferase; Region: Bac_transf; pfam02397 936157006268 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 936157006269 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 936157006270 active site 936157006271 substrate binding site [chemical binding]; other site 936157006272 metal binding site [ion binding]; metal-binding site 936157006273 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 936157006274 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 936157006275 Substrate binding site; other site 936157006276 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 936157006277 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 936157006278 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 936157006279 active site 936157006280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 936157006281 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 936157006282 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 936157006283 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 936157006284 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 936157006285 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 936157006286 substrate binding site; other site 936157006287 tetramer interface; other site 936157006288 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 936157006289 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 936157006290 NADP binding site [chemical binding]; other site 936157006291 active site 936157006292 putative substrate binding site [chemical binding]; other site 936157006293 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 936157006294 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 936157006295 NAD binding site [chemical binding]; other site 936157006296 substrate binding site [chemical binding]; other site 936157006297 homodimer interface [polypeptide binding]; other site 936157006298 active site 936157006299 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 936157006300 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 936157006301 active site 936157006302 tetramer interface; other site 936157006303 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 936157006304 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 936157006305 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 936157006306 putative ADP-binding pocket [chemical binding]; other site 936157006307 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 936157006308 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 936157006309 colanic acid exporter; Provisional; Region: PRK10459 936157006310 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 936157006311 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 936157006312 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 936157006313 phosphomannomutase CpsG; Provisional; Region: PRK15414 936157006314 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 936157006315 active site 936157006316 substrate binding site [chemical binding]; other site 936157006317 metal binding site [ion binding]; metal-binding site 936157006318 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 936157006319 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 936157006320 Substrate binding site; other site 936157006321 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 936157006322 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 936157006323 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 936157006324 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 936157006325 active site 936157006326 GDP-Mannose binding site [chemical binding]; other site 936157006327 dimer interface [polypeptide binding]; other site 936157006328 modified nudix motif 936157006329 metal binding site [ion binding]; metal-binding site 936157006330 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 936157006331 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 936157006332 NADP binding site [chemical binding]; other site 936157006333 active site 936157006334 putative substrate binding site [chemical binding]; other site 936157006335 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 936157006336 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 936157006337 NADP-binding site; other site 936157006338 homotetramer interface [polypeptide binding]; other site 936157006339 substrate binding site [chemical binding]; other site 936157006340 homodimer interface [polypeptide binding]; other site 936157006341 active site 936157006342 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 936157006343 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 936157006344 putative trimer interface [polypeptide binding]; other site 936157006345 putative active site [active] 936157006346 putative substrate binding site [chemical binding]; other site 936157006347 putative CoA binding site [chemical binding]; other site 936157006348 putative glycosyl transferase; Provisional; Region: PRK10063 936157006349 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 936157006350 metal-binding site 936157006351 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 936157006352 putative acyl transferase; Provisional; Region: PRK10191 936157006353 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 936157006354 trimer interface [polypeptide binding]; other site 936157006355 active site 936157006356 substrate binding site [chemical binding]; other site 936157006357 CoA binding site [chemical binding]; other site 936157006358 putative glycosyl transferase; Provisional; Region: PRK10018 936157006359 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 936157006360 active site 936157006361 tyrosine kinase; Provisional; Region: PRK11519 936157006362 Chain length determinant protein; Region: Wzz; pfam02706 936157006363 Chain length determinant protein; Region: Wzz; cl15801 936157006364 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 936157006365 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 936157006366 Low molecular weight phosphatase family; Region: LMWPc; cd00115 936157006367 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 936157006368 active site 936157006369 polysaccharide export protein Wza; Provisional; Region: PRK15078 936157006370 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 936157006371 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 936157006372 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 936157006373 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 936157006374 Transporter associated domain; Region: CorC_HlyC; smart01091 936157006375 putative assembly protein; Provisional; Region: PRK10833 936157006376 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 936157006377 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 936157006378 trimer interface [polypeptide binding]; other site 936157006379 active site 936157006380 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 936157006381 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 936157006382 ATP-binding site [chemical binding]; other site 936157006383 Sugar specificity; other site 936157006384 Pyrimidine base specificity; other site 936157006385 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 936157006386 PAS domain S-box; Region: sensory_box; TIGR00229 936157006387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936157006388 putative active site [active] 936157006389 heme pocket [chemical binding]; other site 936157006390 PAS domain S-box; Region: sensory_box; TIGR00229 936157006391 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936157006392 putative active site [active] 936157006393 heme pocket [chemical binding]; other site 936157006394 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 936157006395 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936157006396 metal binding site [ion binding]; metal-binding site 936157006397 active site 936157006398 I-site; other site 936157006399 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157006400 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 936157006401 AlkA N-terminal domain; Region: AlkA_N; pfam06029 936157006402 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 936157006403 minor groove reading motif; other site 936157006404 helix-hairpin-helix signature motif; other site 936157006405 substrate binding pocket [chemical binding]; other site 936157006406 active site 936157006407 putative chaperone; Provisional; Region: PRK11678 936157006408 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 936157006409 nucleotide binding site [chemical binding]; other site 936157006410 putative NEF/HSP70 interaction site [polypeptide binding]; other site 936157006411 SBD interface [polypeptide binding]; other site 936157006412 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 936157006413 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936157006414 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157006415 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 936157006416 Protein export membrane protein; Region: SecD_SecF; cl14618 936157006417 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 936157006418 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 936157006419 putative transporter; Provisional; Region: PRK10504 936157006420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157006421 putative substrate translocation pore; other site 936157006422 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 936157006423 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157006424 dimerization interface [polypeptide binding]; other site 936157006425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157006426 dimer interface [polypeptide binding]; other site 936157006427 phosphorylation site [posttranslational modification] 936157006428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157006429 ATP binding site [chemical binding]; other site 936157006430 Mg2+ binding site [ion binding]; other site 936157006431 G-X-G motif; other site 936157006432 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 936157006433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157006434 active site 936157006435 phosphorylation site [posttranslational modification] 936157006436 intermolecular recognition site; other site 936157006437 dimerization interface [polypeptide binding]; other site 936157006438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157006439 DNA binding site [nucleotide binding] 936157006440 PcfJ-like protein; Region: PcfJ; pfam14284 936157006441 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 936157006442 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 936157006443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 936157006444 TPR motif; other site 936157006445 Tetratricopeptide repeat; Region: TPR_12; pfam13424 936157006446 binding surface 936157006447 putative protease; Provisional; Region: PRK15452 936157006448 Peptidase family U32; Region: Peptidase_U32; pfam01136 936157006449 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 936157006450 lipid kinase; Reviewed; Region: PRK13054 936157006451 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 936157006452 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 936157006453 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 936157006454 putative active site; other site 936157006455 catalytic residue [active] 936157006456 nucleoside transporter; Region: 2A0110; TIGR00889 936157006457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157006458 putative substrate translocation pore; other site 936157006459 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 936157006460 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936157006461 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 936157006462 substrate binding site [chemical binding]; other site 936157006463 ATP binding site [chemical binding]; other site 936157006464 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 936157006465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157006466 DNA-binding site [nucleotide binding]; DNA binding site 936157006467 UTRA domain; Region: UTRA; pfam07702 936157006468 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 936157006469 dimer interface [polypeptide binding]; other site 936157006470 substrate binding site [chemical binding]; other site 936157006471 ATP binding site [chemical binding]; other site 936157006472 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 936157006473 substrate binding site [chemical binding]; other site 936157006474 multimerization interface [polypeptide binding]; other site 936157006475 ATP binding site [chemical binding]; other site 936157006476 Predicted integral membrane protein [Function unknown]; Region: COG5455 936157006477 Fimbrial protein; Region: Fimbrial; pfam00419 936157006478 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 936157006479 PapC N-terminal domain; Region: PapC_N; pfam13954 936157006480 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 936157006481 PapC C-terminal domain; Region: PapC_C; pfam13953 936157006482 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 936157006483 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 936157006484 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 936157006485 antiporter inner membrane protein; Provisional; Region: PRK11670 936157006486 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 936157006487 Walker A motif; other site 936157006488 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 936157006489 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 936157006490 active site 936157006491 HIGH motif; other site 936157006492 KMSKS motif; other site 936157006493 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 936157006494 tRNA binding surface [nucleotide binding]; other site 936157006495 anticodon binding site; other site 936157006496 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 936157006497 dimer interface [polypeptide binding]; other site 936157006498 putative tRNA-binding site [nucleotide binding]; other site 936157006499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 936157006500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 936157006501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 936157006502 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 936157006503 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 936157006504 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 936157006505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157006506 active site 936157006507 phosphorylation site [posttranslational modification] 936157006508 intermolecular recognition site; other site 936157006509 dimerization interface [polypeptide binding]; other site 936157006510 LytTr DNA-binding domain; Region: LytTR; pfam04397 936157006511 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 936157006512 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 936157006513 GAF domain; Region: GAF; pfam01590 936157006514 Histidine kinase; Region: His_kinase; pfam06580 936157006515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157006516 ATP binding site [chemical binding]; other site 936157006517 Mg2+ binding site [ion binding]; other site 936157006518 G-X-G motif; other site 936157006519 transcriptional regulator MirA; Provisional; Region: PRK15043 936157006520 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 936157006521 DNA binding residues [nucleotide binding] 936157006522 hypothetical protein; Provisional; Region: PRK13681 936157006523 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 936157006524 putative PBP binding loops; other site 936157006525 ABC-ATPase subunit interface; other site 936157006526 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 936157006527 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 936157006528 Walker A/P-loop; other site 936157006529 ATP binding site [chemical binding]; other site 936157006530 Q-loop/lid; other site 936157006531 ABC transporter signature motif; other site 936157006532 Walker B; other site 936157006533 D-loop; other site 936157006534 H-loop/switch region; other site 936157006535 CBS domain; Region: CBS; pfam00571 936157006536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157006537 dimer interface [polypeptide binding]; other site 936157006538 conserved gate region; other site 936157006539 ABC-ATPase subunit interface; other site 936157006540 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 936157006541 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 936157006542 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 936157006543 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 936157006544 D-lactate dehydrogenase; Provisional; Region: PRK11183 936157006545 FAD binding domain; Region: FAD_binding_4; pfam01565 936157006546 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 936157006547 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 936157006548 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 936157006549 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 936157006550 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 936157006551 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 936157006552 oxidoreductase; Provisional; Region: PRK12743 936157006553 classical (c) SDRs; Region: SDR_c; cd05233 936157006554 NAD(P) binding site [chemical binding]; other site 936157006555 active site 936157006556 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 936157006557 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 936157006558 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 936157006559 FMN binding site [chemical binding]; other site 936157006560 active site 936157006561 catalytic residues [active] 936157006562 substrate binding site [chemical binding]; other site 936157006563 salicylate hydroxylase; Provisional; Region: PRK08163 936157006564 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 936157006565 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 936157006566 maleylacetoacetate isomerase; Region: maiA; TIGR01262 936157006567 C-terminal domain interface [polypeptide binding]; other site 936157006568 GSH binding site (G-site) [chemical binding]; other site 936157006569 putative dimer interface [polypeptide binding]; other site 936157006570 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 936157006571 dimer interface [polypeptide binding]; other site 936157006572 N-terminal domain interface [polypeptide binding]; other site 936157006573 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 936157006574 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 936157006575 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 936157006576 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 936157006577 Cupin domain; Region: Cupin_2; pfam07883 936157006578 Cupin domain; Region: Cupin_2; pfam07883 936157006579 benzoate transport; Region: 2A0115; TIGR00895 936157006580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157006581 putative substrate translocation pore; other site 936157006582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157006583 putative substrate translocation pore; other site 936157006584 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 936157006585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157006586 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 936157006587 dimerization interface [polypeptide binding]; other site 936157006588 hypothetical protein; Provisional; Region: PRK01821 936157006589 hypothetical protein; Provisional; Region: PRK10711 936157006590 cytidine deaminase; Provisional; Region: PRK09027 936157006591 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 936157006592 active site 936157006593 catalytic motif [active] 936157006594 Zn binding site [ion binding]; other site 936157006595 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 936157006596 active site 936157006597 catalytic motif [active] 936157006598 Zn binding site [ion binding]; other site 936157006599 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 936157006600 putative active site [active] 936157006601 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 936157006602 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 936157006603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 936157006604 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936157006605 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 936157006606 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 936157006607 homodimer interface [polypeptide binding]; other site 936157006608 active site 936157006609 FMN binding site [chemical binding]; other site 936157006610 substrate binding site [chemical binding]; other site 936157006611 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 936157006612 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 936157006613 TM-ABC transporter signature motif; other site 936157006614 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 936157006615 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 936157006616 Walker A/P-loop; other site 936157006617 ATP binding site [chemical binding]; other site 936157006618 Q-loop/lid; other site 936157006619 ABC transporter signature motif; other site 936157006620 Walker B; other site 936157006621 D-loop; other site 936157006622 H-loop/switch region; other site 936157006623 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 936157006624 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 936157006625 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 936157006626 ligand binding site [chemical binding]; other site 936157006627 calcium binding site [ion binding]; other site 936157006628 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 936157006629 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157006630 DNA binding site [nucleotide binding] 936157006631 domain linker motif; other site 936157006632 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 936157006633 dimerization interface (closed form) [polypeptide binding]; other site 936157006634 ligand binding site [chemical binding]; other site 936157006635 Predicted membrane protein [Function unknown]; Region: COG2311 936157006636 hypothetical protein; Provisional; Region: PRK10835 936157006637 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 936157006638 GTP cyclohydrolase I; Provisional; Region: PLN03044 936157006639 active site 936157006640 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 936157006641 S-formylglutathione hydrolase; Region: PLN02442 936157006642 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936157006643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157006644 non-specific DNA binding site [nucleotide binding]; other site 936157006645 salt bridge; other site 936157006646 sequence-specific DNA binding site [nucleotide binding]; other site 936157006647 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 936157006648 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 936157006649 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 936157006650 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 936157006651 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 936157006652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157006653 motif II; other site 936157006654 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 936157006655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157006656 putative substrate translocation pore; other site 936157006657 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 936157006658 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 936157006659 N-terminal plug; other site 936157006660 ligand-binding site [chemical binding]; other site 936157006661 lysine transporter; Provisional; Region: PRK10836 936157006662 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 936157006663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157006664 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 936157006665 putative dimerization interface [polypeptide binding]; other site 936157006666 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 936157006667 endonuclease IV; Provisional; Region: PRK01060 936157006668 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 936157006669 AP (apurinic/apyrimidinic) site pocket; other site 936157006670 DNA interaction; other site 936157006671 Metal-binding active site; metal-binding site 936157006672 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 936157006673 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 936157006674 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 936157006675 active site 936157006676 P-loop; other site 936157006677 phosphorylation site [posttranslational modification] 936157006678 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 936157006679 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 936157006680 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 936157006681 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 936157006682 putative substrate binding site [chemical binding]; other site 936157006683 putative ATP binding site [chemical binding]; other site 936157006684 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 936157006685 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936157006686 active site 936157006687 phosphorylation site [posttranslational modification] 936157006688 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 936157006689 dimerization domain swap beta strand [polypeptide binding]; other site 936157006690 regulatory protein interface [polypeptide binding]; other site 936157006691 active site 936157006692 regulatory phosphorylation site [posttranslational modification]; other site 936157006693 sugar efflux transporter B; Provisional; Region: PRK15011 936157006694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157006695 putative substrate translocation pore; other site 936157006696 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 936157006697 Flagellin N-methylase; Region: FliB; cl00497 936157006698 elongation factor P; Provisional; Region: PRK04542 936157006699 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 936157006700 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 936157006701 RNA binding site [nucleotide binding]; other site 936157006702 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 936157006703 RNA binding site [nucleotide binding]; other site 936157006704 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 936157006705 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 936157006706 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 936157006707 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 936157006708 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 936157006709 active site 936157006710 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 936157006711 NlpC/P60 family; Region: NLPC_P60; pfam00877 936157006712 phage resistance protein; Provisional; Region: PRK10551 936157006713 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 936157006714 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157006715 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 936157006716 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 936157006717 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 936157006718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157006719 dimer interface [polypeptide binding]; other site 936157006720 conserved gate region; other site 936157006721 putative PBP binding loops; other site 936157006722 ABC-ATPase subunit interface; other site 936157006723 microcin C ABC transporter permease; Provisional; Region: PRK15021 936157006724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157006725 dimer interface [polypeptide binding]; other site 936157006726 conserved gate region; other site 936157006727 ABC-ATPase subunit interface; other site 936157006728 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 936157006729 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936157006730 Walker A/P-loop; other site 936157006731 ATP binding site [chemical binding]; other site 936157006732 Q-loop/lid; other site 936157006733 ABC transporter signature motif; other site 936157006734 Walker B; other site 936157006735 D-loop; other site 936157006736 H-loop/switch region; other site 936157006737 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 936157006738 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936157006739 Walker A/P-loop; other site 936157006740 ATP binding site [chemical binding]; other site 936157006741 Q-loop/lid; other site 936157006742 ABC transporter signature motif; other site 936157006743 Walker B; other site 936157006744 D-loop; other site 936157006745 H-loop/switch region; other site 936157006746 hypothetical protein; Provisional; Region: PRK11835 936157006747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157006748 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 936157006749 putative substrate translocation pore; other site 936157006750 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 936157006751 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936157006752 RNA binding surface [nucleotide binding]; other site 936157006753 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 936157006754 active site 936157006755 uracil binding [chemical binding]; other site 936157006756 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 936157006757 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936157006758 ATP binding site [chemical binding]; other site 936157006759 putative Mg++ binding site [ion binding]; other site 936157006760 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157006761 nucleotide binding region [chemical binding]; other site 936157006762 ATP-binding site [chemical binding]; other site 936157006763 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 936157006764 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 936157006765 5S rRNA interface [nucleotide binding]; other site 936157006766 CTC domain interface [polypeptide binding]; other site 936157006767 L16 interface [polypeptide binding]; other site 936157006768 Nucleoid-associated protein [General function prediction only]; Region: COG3081 936157006769 nucleoid-associated protein NdpA; Validated; Region: PRK00378 936157006770 hypothetical protein; Provisional; Region: PRK13689 936157006771 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 936157006772 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 936157006773 Sulfatase; Region: Sulfatase; cl17466 936157006774 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 936157006775 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 936157006776 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 936157006777 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 936157006778 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 936157006779 Substrate binding site [chemical binding]; other site 936157006780 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 936157006781 DinI-like family; Region: DinI; cl11630 936157006782 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 936157006783 transcriptional regulator NarP; Provisional; Region: PRK10403 936157006784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157006785 active site 936157006786 phosphorylation site [posttranslational modification] 936157006787 intermolecular recognition site; other site 936157006788 dimerization interface [polypeptide binding]; other site 936157006789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157006790 DNA binding residues [nucleotide binding] 936157006791 dimerization interface [polypeptide binding]; other site 936157006792 Cytochrome C biogenesis protein; Region: CcmH; cl01179 936157006793 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 936157006794 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 936157006795 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 936157006796 catalytic residues [active] 936157006797 central insert; other site 936157006798 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 936157006799 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 936157006800 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 936157006801 heme exporter protein CcmC; Region: ccmC; TIGR01191 936157006802 heme exporter protein CcmB; Region: ccmB; TIGR01190 936157006803 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 936157006804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157006805 Walker A/P-loop; other site 936157006806 ATP binding site [chemical binding]; other site 936157006807 Q-loop/lid; other site 936157006808 ABC transporter signature motif; other site 936157006809 Walker B; other site 936157006810 D-loop; other site 936157006811 H-loop/switch region; other site 936157006812 cytochrome c-type protein NapC; Provisional; Region: PRK10617 936157006813 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 936157006814 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 936157006815 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 936157006816 4Fe-4S binding domain; Region: Fer4_5; pfam12801 936157006817 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936157006818 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 936157006819 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 936157006820 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 936157006821 [4Fe-4S] binding site [ion binding]; other site 936157006822 molybdopterin cofactor binding site; other site 936157006823 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 936157006824 molybdopterin cofactor binding site; other site 936157006825 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 936157006826 ferredoxin-type protein; Provisional; Region: PRK10194 936157006827 4Fe-4S binding domain; Region: Fer4; cl02805 936157006828 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 936157006829 secondary substrate binding site; other site 936157006830 primary substrate binding site; other site 936157006831 inhibition loop; other site 936157006832 dimerization interface [polypeptide binding]; other site 936157006833 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 936157006834 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 936157006835 Walker A/P-loop; other site 936157006836 ATP binding site [chemical binding]; other site 936157006837 Q-loop/lid; other site 936157006838 ABC transporter signature motif; other site 936157006839 Walker B; other site 936157006840 D-loop; other site 936157006841 H-loop/switch region; other site 936157006842 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 936157006843 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 936157006844 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 936157006845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157006846 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 936157006847 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 936157006848 DNA binding site [nucleotide binding] 936157006849 active site 936157006850 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 936157006851 ApbE family; Region: ApbE; pfam02424 936157006852 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 936157006853 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 936157006854 trimer interface [polypeptide binding]; other site 936157006855 eyelet of channel; other site 936157006856 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 936157006857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157006858 ATP binding site [chemical binding]; other site 936157006859 G-X-G motif; other site 936157006860 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 936157006861 putative binding surface; other site 936157006862 active site 936157006863 transcriptional regulator RcsB; Provisional; Region: PRK10840 936157006864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157006865 active site 936157006866 phosphorylation site [posttranslational modification] 936157006867 intermolecular recognition site; other site 936157006868 dimerization interface [polypeptide binding]; other site 936157006869 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157006870 DNA binding residues [nucleotide binding] 936157006871 dimerization interface [polypeptide binding]; other site 936157006872 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 936157006873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157006874 dimer interface [polypeptide binding]; other site 936157006875 phosphorylation site [posttranslational modification] 936157006876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157006877 ATP binding site [chemical binding]; other site 936157006878 Mg2+ binding site [ion binding]; other site 936157006879 G-X-G motif; other site 936157006880 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 936157006881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157006882 active site 936157006883 phosphorylation site [posttranslational modification] 936157006884 intermolecular recognition site; other site 936157006885 dimerization interface [polypeptide binding]; other site 936157006888 DNA gyrase subunit A; Validated; Region: PRK05560 936157006889 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 936157006890 CAP-like domain; other site 936157006891 active site 936157006892 primary dimer interface [polypeptide binding]; other site 936157006893 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936157006894 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936157006895 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936157006896 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936157006897 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936157006898 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936157006899 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 936157006900 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 936157006901 active site pocket [active] 936157006902 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 936157006903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157006904 putative substrate translocation pore; other site 936157006905 Transcriptional regulators [Transcription]; Region: GntR; COG1802 936157006906 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157006907 DNA-binding site [nucleotide binding]; DNA binding site 936157006908 FCD domain; Region: FCD; pfam07729 936157006909 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 936157006910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157006911 S-adenosylmethionine binding site [chemical binding]; other site 936157006912 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 936157006913 ATP cone domain; Region: ATP-cone; pfam03477 936157006914 Class I ribonucleotide reductase; Region: RNR_I; cd01679 936157006915 active site 936157006916 dimer interface [polypeptide binding]; other site 936157006917 catalytic residues [active] 936157006918 effector binding site; other site 936157006919 R2 peptide binding site; other site 936157006920 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 936157006921 dimer interface [polypeptide binding]; other site 936157006922 putative radical transfer pathway; other site 936157006923 diiron center [ion binding]; other site 936157006924 tyrosyl radical; other site 936157006925 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 936157006926 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 936157006927 catalytic loop [active] 936157006928 iron binding site [ion binding]; other site 936157006929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936157006930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157006931 putative substrate translocation pore; other site 936157006932 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 936157006933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157006934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936157006935 dimerization interface [polypeptide binding]; other site 936157006936 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 936157006937 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 936157006938 active site 936157006939 catalytic site [active] 936157006940 metal binding site [ion binding]; metal-binding site 936157006941 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 936157006942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157006943 putative substrate translocation pore; other site 936157006944 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 936157006945 hydroxyglutarate oxidase; Provisional; Region: PRK11728 936157006946 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 936157006947 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 936157006948 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 936157006949 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 936157006950 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936157006951 Cysteine-rich domain; Region: CCG; pfam02754 936157006952 Cysteine-rich domain; Region: CCG; pfam02754 936157006953 deubiquitinase SseL; Provisional; Region: PRK14848 936157006954 hypothetical protein; Provisional; Region: PRK03673 936157006955 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 936157006956 putative MPT binding site; other site 936157006957 Competence-damaged protein; Region: CinA; cl00666 936157006958 YfaZ precursor; Region: YfaZ; pfam07437 936157006959 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 936157006960 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 936157006961 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 936157006962 catalytic core [active] 936157006963 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 936157006964 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 936157006965 inhibitor-cofactor binding pocket; inhibition site 936157006966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157006967 catalytic residue [active] 936157006968 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 936157006969 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 936157006970 Ligand binding site; other site 936157006971 Putative Catalytic site; other site 936157006972 DXD motif; other site 936157006973 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 936157006974 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 936157006975 active site 936157006976 substrate binding site [chemical binding]; other site 936157006977 cosubstrate binding site; other site 936157006978 catalytic site [active] 936157006979 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 936157006980 active site 936157006981 hexamer interface [polypeptide binding]; other site 936157006982 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 936157006983 NAD binding site [chemical binding]; other site 936157006984 substrate binding site [chemical binding]; other site 936157006985 active site 936157006986 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 936157006987 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 936157006988 putative active site [active] 936157006989 putative catalytic site [active] 936157006990 putative Zn binding site [ion binding]; other site 936157006991 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 936157006992 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 936157006993 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 936157006994 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 936157006995 signal transduction protein PmrD; Provisional; Region: PRK15450 936157006996 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 936157006997 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 936157006998 acyl-activating enzyme (AAE) consensus motif; other site 936157006999 putative AMP binding site [chemical binding]; other site 936157007000 putative active site [active] 936157007001 putative CoA binding site [chemical binding]; other site 936157007002 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 936157007003 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 936157007004 active site 936157007005 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 936157007006 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 936157007007 substrate binding site [chemical binding]; other site 936157007008 oxyanion hole (OAH) forming residues; other site 936157007009 trimer interface [polypeptide binding]; other site 936157007010 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 936157007011 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 936157007012 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 936157007013 dimer interface [polypeptide binding]; other site 936157007014 tetramer interface [polypeptide binding]; other site 936157007015 PYR/PP interface [polypeptide binding]; other site 936157007016 TPP binding site [chemical binding]; other site 936157007017 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 936157007018 TPP-binding site; other site 936157007019 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 936157007020 isochorismate synthases; Region: isochor_syn; TIGR00543 936157007021 hypothetical protein; Provisional; Region: PRK10404 936157007022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157007023 Coenzyme A binding pocket [chemical binding]; other site 936157007024 ribonuclease BN; Region: true_RNase_BN; TIGR02649 936157007025 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 936157007026 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 936157007027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157007028 active site 936157007029 phosphorylation site [posttranslational modification] 936157007030 intermolecular recognition site; other site 936157007031 dimerization interface [polypeptide binding]; other site 936157007032 von Willebrand factor; Region: vWF_A; pfam12450 936157007033 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 936157007034 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 936157007035 metal ion-dependent adhesion site (MIDAS); other site 936157007036 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 936157007037 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 936157007038 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 936157007039 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 936157007040 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 936157007041 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 936157007042 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 936157007043 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 936157007044 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 936157007045 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 936157007046 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 936157007047 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 936157007048 4Fe-4S binding domain; Region: Fer4; pfam00037 936157007049 4Fe-4S binding domain; Region: Fer4; pfam00037 936157007050 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 936157007051 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 936157007052 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 936157007053 catalytic loop [active] 936157007054 iron binding site [ion binding]; other site 936157007055 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 936157007056 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 936157007057 [4Fe-4S] binding site [ion binding]; other site 936157007058 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 936157007059 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 936157007060 SLBB domain; Region: SLBB; pfam10531 936157007061 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 936157007062 NADH dehydrogenase subunit E; Validated; Region: PRK07539 936157007063 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 936157007064 putative dimer interface [polypeptide binding]; other site 936157007065 [2Fe-2S] cluster binding site [ion binding]; other site 936157007066 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 936157007067 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 936157007068 NADH dehydrogenase subunit D; Validated; Region: PRK06075 936157007069 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 936157007070 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 936157007071 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 936157007072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157007073 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 936157007074 putative dimerization interface [polypeptide binding]; other site 936157007075 aminotransferase AlaT; Validated; Region: PRK09265 936157007076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936157007077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157007078 homodimer interface [polypeptide binding]; other site 936157007079 catalytic residue [active] 936157007080 5'-nucleotidase; Provisional; Region: PRK03826 936157007081 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 936157007082 transmembrane helices; other site 936157007083 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 936157007084 TrkA-C domain; Region: TrkA_C; pfam02080 936157007085 TrkA-C domain; Region: TrkA_C; pfam02080 936157007086 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 936157007087 putative phosphatase; Provisional; Region: PRK11587 936157007088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157007089 motif II; other site 936157007090 hypothetical protein; Validated; Region: PRK05445 936157007091 hypothetical protein; Provisional; Region: PRK01816 936157007092 propionate/acetate kinase; Provisional; Region: PRK12379 936157007093 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 936157007094 phosphate acetyltransferase; Reviewed; Region: PRK05632 936157007095 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 936157007096 DRTGG domain; Region: DRTGG; pfam07085 936157007097 phosphate acetyltransferase; Region: pta; TIGR00651 936157007098 hypothetical protein; Provisional; Region: PRK11588 936157007099 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 936157007100 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 936157007101 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 936157007102 PYR/PP interface [polypeptide binding]; other site 936157007103 dimer interface [polypeptide binding]; other site 936157007104 TPP binding site [chemical binding]; other site 936157007105 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 936157007106 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 936157007107 TPP-binding site [chemical binding]; other site 936157007108 dimer interface [polypeptide binding]; other site 936157007109 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 936157007110 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 936157007111 active site 936157007112 P-loop; other site 936157007113 phosphorylation site [posttranslational modification] 936157007114 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936157007115 active site 936157007116 phosphorylation site [posttranslational modification] 936157007117 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936157007118 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157007119 DNA binding site [nucleotide binding] 936157007120 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 936157007121 putative dimerization interface [polypeptide binding]; other site 936157007122 putative ligand binding site [chemical binding]; other site 936157007123 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 936157007124 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 936157007125 nudix motif; other site 936157007126 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 936157007127 active site 936157007128 metal binding site [ion binding]; metal-binding site 936157007129 homotetramer interface [polypeptide binding]; other site 936157007130 glutathione S-transferase; Provisional; Region: PRK15113 936157007131 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 936157007132 C-terminal domain interface [polypeptide binding]; other site 936157007133 GSH binding site (G-site) [chemical binding]; other site 936157007134 dimer interface [polypeptide binding]; other site 936157007135 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 936157007136 N-terminal domain interface [polypeptide binding]; other site 936157007137 putative dimer interface [polypeptide binding]; other site 936157007138 putative substrate binding pocket (H-site) [chemical binding]; other site 936157007139 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 936157007140 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 936157007141 C-terminal domain interface [polypeptide binding]; other site 936157007142 GSH binding site (G-site) [chemical binding]; other site 936157007143 dimer interface [polypeptide binding]; other site 936157007144 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 936157007145 N-terminal domain interface [polypeptide binding]; other site 936157007146 putative dimer interface [polypeptide binding]; other site 936157007147 active site 936157007148 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 936157007149 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 936157007150 putative NAD(P) binding site [chemical binding]; other site 936157007151 putative active site [active] 936157007152 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 936157007153 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 936157007154 Walker A/P-loop; other site 936157007155 ATP binding site [chemical binding]; other site 936157007156 Q-loop/lid; other site 936157007157 ABC transporter signature motif; other site 936157007158 Walker B; other site 936157007159 D-loop; other site 936157007160 H-loop/switch region; other site 936157007161 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 936157007162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157007163 dimer interface [polypeptide binding]; other site 936157007164 conserved gate region; other site 936157007165 putative PBP binding loops; other site 936157007166 ABC-ATPase subunit interface; other site 936157007167 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 936157007168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157007169 dimer interface [polypeptide binding]; other site 936157007170 conserved gate region; other site 936157007171 putative PBP binding loops; other site 936157007172 ABC-ATPase subunit interface; other site 936157007173 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 936157007174 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157007175 substrate binding pocket [chemical binding]; other site 936157007176 membrane-bound complex binding site; other site 936157007177 hinge residues; other site 936157007178 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 936157007179 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157007180 substrate binding pocket [chemical binding]; other site 936157007181 membrane-bound complex binding site; other site 936157007182 hinge residues; other site 936157007183 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 936157007184 Flavoprotein; Region: Flavoprotein; pfam02441 936157007185 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 936157007186 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 936157007187 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 936157007188 dimer interface [polypeptide binding]; other site 936157007189 active site 936157007190 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936157007191 substrate binding site [chemical binding]; other site 936157007192 catalytic residue [active] 936157007193 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 936157007194 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 936157007195 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 936157007196 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936157007197 catalytic residue [active] 936157007198 PAS fold; Region: PAS_4; pfam08448 936157007199 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 936157007200 putative active site [active] 936157007201 heme pocket [chemical binding]; other site 936157007202 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 936157007203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157007204 Walker A motif; other site 936157007205 ATP binding site [chemical binding]; other site 936157007206 Walker B motif; other site 936157007207 arginine finger; other site 936157007208 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 936157007209 amidophosphoribosyltransferase; Provisional; Region: PRK09246 936157007210 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 936157007211 active site 936157007212 tetramer interface [polypeptide binding]; other site 936157007213 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936157007214 active site 936157007215 colicin V production protein; Provisional; Region: PRK10845 936157007216 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 936157007217 cell division protein DedD; Provisional; Region: PRK11633 936157007218 Sporulation related domain; Region: SPOR; pfam05036 936157007219 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 936157007220 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936157007221 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936157007222 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 936157007223 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 936157007224 hypothetical protein; Provisional; Region: PRK10847 936157007225 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 936157007226 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 936157007227 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 936157007228 dimerization interface 3.5A [polypeptide binding]; other site 936157007229 active site 936157007230 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 936157007231 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 936157007232 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 936157007233 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 936157007234 ligand binding site [chemical binding]; other site 936157007235 NAD binding site [chemical binding]; other site 936157007236 catalytic site [active] 936157007237 homodimer interface [polypeptide binding]; other site 936157007238 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 936157007239 putative transporter; Provisional; Region: PRK12382 936157007240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157007241 putative substrate translocation pore; other site 936157007242 Repressor protein CI 936157007243 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 936157007244 CAAX protease self-immunity; Region: Abi; pfam02517 936157007245 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 936157007246 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 936157007247 dimer interface [polypeptide binding]; other site 936157007248 active site 936157007249 Uncharacterized conserved protein [Function unknown]; Region: COG4121 936157007250 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 936157007251 YfcL protein; Region: YfcL; pfam08891 936157007252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 936157007253 hypothetical protein; Provisional; Region: PRK10621 936157007254 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 936157007255 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 936157007256 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 936157007257 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 936157007258 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 936157007259 Tetramer interface [polypeptide binding]; other site 936157007260 active site 936157007261 FMN-binding site [chemical binding]; other site 936157007262 HemK family putative methylases; Region: hemK_fam; TIGR00536 936157007263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157007264 S-adenosylmethionine binding site [chemical binding]; other site 936157007265 hypothetical protein; Provisional; Region: PRK04946 936157007266 Smr domain; Region: Smr; pfam01713 936157007267 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 936157007268 catalytic core [active] 936157007269 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 936157007270 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 936157007271 substrate binding site [chemical binding]; other site 936157007272 oxyanion hole (OAH) forming residues; other site 936157007273 trimer interface [polypeptide binding]; other site 936157007274 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 936157007275 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 936157007276 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 936157007277 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 936157007278 dimer interface [polypeptide binding]; other site 936157007279 active site 936157007280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 936157007281 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 936157007282 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 936157007283 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 936157007284 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 936157007285 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 936157007286 active site 936157007287 Int/Topo IB signature motif; other site 936157007288 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 936157007289 Head binding; Region: Head_binding; pfam09008 936157007290 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 936157007291 active site 936157007292 catalytic triad [active] 936157007293 oxyanion hole [active] 936157007294 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 936157007295 Protein of unknown function (DUF812); Region: DUF812; pfam05667 936157007296 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 936157007297 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 936157007298 coat protein; Region: PHA01511 936157007299 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 936157007300 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 936157007301 Terminase-like family; Region: Terminase_6; pfam03237 936157007302 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 936157007303 Phage terminase large subunit; Region: Terminase_3; cl12054 936157007304 hypothetical protein; Region: PHA00780 936157007305 KilA-N domain; Region: KilA-N; pfam04383 936157007306 ORF11CD3 domain; Region: ORF11CD3; pfam10549 936157007307 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 936157007308 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 936157007309 catalytic residues [active] 936157007310 phage holin, lambda family; Region: holin_lambda; TIGR01594 936157007311 Antitermination protein; Region: Antiterm; pfam03589 936157007312 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 936157007313 Antitermination protein; Region: Antiterm; pfam03589 936157007314 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 936157007315 NinF protein; Region: NinF; pfam05810 936157007316 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 936157007317 NINE Protein; Region: NinE; pfam05322 936157007318 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 936157007319 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 936157007320 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 936157007321 Walker A motif; other site 936157007322 ATP binding site [chemical binding]; other site 936157007323 Walker B motif; other site 936157007324 DNA binding loops [nucleotide binding] 936157007325 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 936157007326 Bacteriophage CII protein; Region: Phage_CII; pfam05269 936157007327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157007328 sequence-specific DNA binding site [nucleotide binding]; other site 936157007329 salt bridge; other site 936157007330 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157007331 non-specific DNA binding site [nucleotide binding]; other site 936157007332 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 936157007333 salt bridge; other site 936157007334 sequence-specific DNA binding site [nucleotide binding]; other site 936157007335 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 936157007336 Catalytic site [active] 936157007337 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 936157007338 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 936157007339 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 936157007340 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 936157007341 dimer interface [polypeptide binding]; other site 936157007342 ssDNA binding site [nucleotide binding]; other site 936157007343 tetramer (dimer of dimers) interface [polypeptide binding]; other site 936157007344 putative single-stranded DNA-binding protein; Region: PHA01740 936157007345 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 936157007346 active site 936157007347 catalytic site [active] 936157007348 substrate binding site [chemical binding]; other site 936157007349 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 936157007350 HNH endonuclease; Region: HNH_3; pfam13392 936157007351 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 936157007352 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 936157007353 active site 936157007354 outer membrane protease; Reviewed; Region: PRK10993 936157007355 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 936157007356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157007357 active site 936157007358 phosphorylation site [posttranslational modification] 936157007359 intermolecular recognition site; other site 936157007360 dimerization interface [polypeptide binding]; other site 936157007361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 936157007362 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 936157007363 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 936157007364 HAMP domain; Region: HAMP; pfam00672 936157007365 dimerization interface [polypeptide binding]; other site 936157007366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157007367 dimer interface [polypeptide binding]; other site 936157007368 phosphorylation site [posttranslational modification] 936157007369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157007370 ATP binding site [chemical binding]; other site 936157007371 Mg2+ binding site [ion binding]; other site 936157007372 G-X-G motif; other site 936157007373 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 936157007374 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 936157007375 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 936157007376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157007377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157007378 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 936157007379 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 936157007380 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 936157007381 putative acyl-acceptor binding pocket; other site 936157007382 aminotransferase; Validated; Region: PRK08175 936157007383 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936157007384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157007385 homodimer interface [polypeptide binding]; other site 936157007386 catalytic residue [active] 936157007387 glucokinase; Provisional; Region: glk; PRK00292 936157007388 glucokinase, proteobacterial type; Region: glk; TIGR00749 936157007389 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 936157007390 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 936157007391 Cl- selectivity filter; other site 936157007392 Cl- binding residues [ion binding]; other site 936157007393 pore gating glutamate residue; other site 936157007394 dimer interface [polypeptide binding]; other site 936157007395 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 936157007396 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 936157007397 dimer interface [polypeptide binding]; other site 936157007398 PYR/PP interface [polypeptide binding]; other site 936157007399 TPP binding site [chemical binding]; other site 936157007400 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 936157007401 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 936157007402 TPP-binding site [chemical binding]; other site 936157007403 dimer interface [polypeptide binding]; other site 936157007404 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936157007405 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936157007406 active site 936157007407 catalytic tetrad [active] 936157007408 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 936157007409 manganese transport protein MntH; Reviewed; Region: PRK00701 936157007410 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 936157007411 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 936157007412 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 936157007413 Nucleoside recognition; Region: Gate; pfam07670 936157007414 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 936157007415 MASE1; Region: MASE1; pfam05231 936157007416 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 936157007417 diguanylate cyclase; Region: GGDEF; smart00267 936157007418 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157007419 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 936157007420 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 936157007421 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 936157007422 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 936157007423 active site 936157007424 HIGH motif; other site 936157007425 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 936157007426 active site 936157007427 KMSKS motif; other site 936157007428 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 936157007429 putative dimerization interface [polypeptide binding]; other site 936157007430 putative substrate binding pocket [chemical binding]; other site 936157007431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157007432 XapX domain; Region: XapX; TIGR03510 936157007433 nucleoside transporter; Region: 2A0110; TIGR00889 936157007434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157007435 putative substrate translocation pore; other site 936157007436 purine nucleoside phosphorylase; Provisional; Region: PRK08202 936157007437 hypothetical protein; Provisional; Region: PRK11528 936157007438 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157007439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157007440 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 936157007441 putative dimerization interface [polypeptide binding]; other site 936157007442 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 936157007443 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 936157007444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 936157007445 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 936157007446 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 936157007447 nucleotide binding pocket [chemical binding]; other site 936157007448 K-X-D-G motif; other site 936157007449 catalytic site [active] 936157007450 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 936157007451 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 936157007452 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 936157007453 Dimer interface [polypeptide binding]; other site 936157007454 BRCT sequence motif; other site 936157007455 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 936157007456 cell division protein ZipA; Provisional; Region: PRK03427 936157007457 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 936157007458 FtsZ protein binding site [polypeptide binding]; other site 936157007459 putative sulfate transport protein CysZ; Validated; Region: PRK04949 936157007460 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 936157007461 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 936157007462 dimer interface [polypeptide binding]; other site 936157007463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157007464 catalytic residue [active] 936157007465 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 936157007466 dimerization domain swap beta strand [polypeptide binding]; other site 936157007467 regulatory protein interface [polypeptide binding]; other site 936157007468 active site 936157007469 regulatory phosphorylation site [posttranslational modification]; other site 936157007470 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 936157007471 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 936157007472 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 936157007473 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 936157007474 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 936157007475 HPr interaction site; other site 936157007476 glycerol kinase (GK) interaction site [polypeptide binding]; other site 936157007477 active site 936157007478 phosphorylation site [posttranslational modification] 936157007479 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 936157007480 dimer interface [polypeptide binding]; other site 936157007481 pyridoxamine kinase; Validated; Region: PRK05756 936157007482 pyridoxal binding site [chemical binding]; other site 936157007483 ATP binding site [chemical binding]; other site 936157007484 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 936157007485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157007486 DNA-binding site [nucleotide binding]; DNA binding site 936157007487 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936157007488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157007489 homodimer interface [polypeptide binding]; other site 936157007490 catalytic residue [active] 936157007491 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 936157007492 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 936157007493 catalytic triad [active] 936157007494 hypothetical protein; Provisional; Region: PRK10318 936157007495 cysteine synthase B; Region: cysM; TIGR01138 936157007496 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 936157007497 dimer interface [polypeptide binding]; other site 936157007498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157007499 catalytic residue [active] 936157007500 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 936157007501 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 936157007502 Walker A/P-loop; other site 936157007503 ATP binding site [chemical binding]; other site 936157007504 Q-loop/lid; other site 936157007505 ABC transporter signature motif; other site 936157007506 Walker B; other site 936157007507 D-loop; other site 936157007508 H-loop/switch region; other site 936157007509 TOBE-like domain; Region: TOBE_3; pfam12857 936157007510 sulfate transport protein; Provisional; Region: cysT; CHL00187 936157007511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157007512 dimer interface [polypeptide binding]; other site 936157007513 conserved gate region; other site 936157007514 putative PBP binding loops; other site 936157007515 ABC-ATPase subunit interface; other site 936157007516 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 936157007517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157007518 dimer interface [polypeptide binding]; other site 936157007519 conserved gate region; other site 936157007520 putative PBP binding loops; other site 936157007521 ABC-ATPase subunit interface; other site 936157007522 thiosulfate transporter subunit; Provisional; Region: PRK10852 936157007523 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 936157007524 short chain dehydrogenase; Provisional; Region: PRK08226 936157007525 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 936157007526 NAD binding site [chemical binding]; other site 936157007527 homotetramer interface [polypeptide binding]; other site 936157007528 homodimer interface [polypeptide binding]; other site 936157007529 active site 936157007530 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 936157007531 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 936157007532 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 936157007533 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 936157007534 putative acetyltransferase; Provisional; Region: PRK03624 936157007535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157007536 Coenzyme A binding pocket [chemical binding]; other site 936157007537 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 936157007538 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 936157007539 active site 936157007540 metal binding site [ion binding]; metal-binding site 936157007541 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 936157007542 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 936157007543 transcriptional regulator EutR; Provisional; Region: PRK10130 936157007544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157007545 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157007546 carboxysome structural protein EutK; Provisional; Region: PRK15466 936157007547 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 936157007548 Hexamer interface [polypeptide binding]; other site 936157007549 Hexagonal pore residue; other site 936157007550 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 936157007551 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 936157007552 putative hexamer interface [polypeptide binding]; other site 936157007553 putative hexagonal pore; other site 936157007554 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 936157007555 putative hexamer interface [polypeptide binding]; other site 936157007556 putative hexagonal pore; other site 936157007557 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 936157007558 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 936157007559 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 936157007560 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 936157007561 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 936157007562 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 936157007563 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 936157007564 active site 936157007565 metal binding site [ion binding]; metal-binding site 936157007566 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 936157007567 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936157007568 nucleotide binding site [chemical binding]; other site 936157007569 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 936157007570 putative catalytic cysteine [active] 936157007571 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 936157007572 Hexamer/Pentamer interface [polypeptide binding]; other site 936157007573 central pore; other site 936157007574 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 936157007575 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 936157007576 Hexamer interface [polypeptide binding]; other site 936157007577 Putative hexagonal pore residue; other site 936157007578 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 936157007579 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 936157007580 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 936157007581 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 936157007582 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 936157007583 putative hexamer interface [polypeptide binding]; other site 936157007584 putative hexagonal pore; other site 936157007585 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 936157007586 Malic enzyme, N-terminal domain; Region: malic; pfam00390 936157007587 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 936157007588 putative NAD(P) binding site [chemical binding]; other site 936157007589 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 936157007590 transaldolase-like protein; Provisional; Region: PTZ00411 936157007591 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 936157007592 active site 936157007593 dimer interface [polypeptide binding]; other site 936157007594 catalytic residue [active] 936157007595 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 936157007596 TPP-binding site [chemical binding]; other site 936157007597 dimer interface [polypeptide binding]; other site 936157007598 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 936157007599 PYR/PP interface [polypeptide binding]; other site 936157007600 TPP binding site [chemical binding]; other site 936157007601 dimer interface [polypeptide binding]; other site 936157007602 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 936157007603 TPP binding site [chemical binding]; other site 936157007604 dimer interface [polypeptide binding]; other site 936157007605 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 936157007606 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 936157007607 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 936157007608 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 936157007609 dimer interface [polypeptide binding]; other site 936157007610 ADP-ribose binding site [chemical binding]; other site 936157007611 active site 936157007612 nudix motif; other site 936157007613 metal binding site [ion binding]; metal-binding site 936157007614 putative periplasmic esterase; Provisional; Region: PRK03642 936157007615 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 936157007616 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 936157007617 4Fe-4S binding domain; Region: Fer4; pfam00037 936157007618 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 936157007619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936157007620 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 936157007621 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 936157007622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157007623 dimerization interface [polypeptide binding]; other site 936157007624 Histidine kinase; Region: HisKA_3; pfam07730 936157007625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157007626 ATP binding site [chemical binding]; other site 936157007627 Mg2+ binding site [ion binding]; other site 936157007628 G-X-G motif; other site 936157007629 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 936157007630 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 936157007631 Protein export membrane protein; Region: SecD_SecF; cl14618 936157007632 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 936157007633 ArsC family; Region: ArsC; pfam03960 936157007634 putative catalytic residues [active] 936157007635 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 936157007636 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 936157007637 metal binding site [ion binding]; metal-binding site 936157007638 dimer interface [polypeptide binding]; other site 936157007639 hypothetical protein; Provisional; Region: PRK13664 936157007640 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 936157007641 Helicase; Region: Helicase_RecD; pfam05127 936157007642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157007643 Coenzyme A binding pocket [chemical binding]; other site 936157007644 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 936157007645 Predicted metalloprotease [General function prediction only]; Region: COG2321 936157007646 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 936157007647 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 936157007648 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 936157007649 ATP binding site [chemical binding]; other site 936157007650 active site 936157007651 substrate binding site [chemical binding]; other site 936157007652 lipoprotein; Provisional; Region: PRK11679 936157007653 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 936157007654 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 936157007655 dihydrodipicolinate synthase; Region: dapA; TIGR00674 936157007656 dimer interface [polypeptide binding]; other site 936157007657 active site 936157007658 catalytic residue [active] 936157007659 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 936157007660 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 936157007661 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 936157007662 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 936157007663 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 936157007664 catalytic triad [active] 936157007665 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 936157007666 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 936157007667 fructuronate transporter; Provisional; Region: PRK10034; cl15264 936157007668 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 936157007669 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 936157007670 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 936157007671 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 936157007672 Domain of unknown function DUF20; Region: UPF0118; pfam01594 936157007673 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 936157007674 Peptidase family M48; Region: Peptidase_M48; cl12018 936157007675 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 936157007676 ArsC family; Region: ArsC; pfam03960 936157007677 catalytic residues [active] 936157007678 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 936157007679 DNA replication initiation factor; Provisional; Region: PRK08084 936157007680 uracil transporter; Provisional; Region: PRK10720 936157007681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936157007682 active site 936157007683 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 936157007684 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 936157007685 dimerization interface [polypeptide binding]; other site 936157007686 putative ATP binding site [chemical binding]; other site 936157007687 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 936157007688 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 936157007689 active site 936157007690 substrate binding site [chemical binding]; other site 936157007691 cosubstrate binding site; other site 936157007692 catalytic site [active] 936157007693 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 936157007694 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 936157007695 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 936157007696 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 936157007697 putative active site [active] 936157007698 catalytic site [active] 936157007699 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 936157007700 domain interface [polypeptide binding]; other site 936157007701 active site 936157007702 catalytic site [active] 936157007703 exopolyphosphatase; Provisional; Region: PRK10854 936157007704 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936157007705 nucleotide binding site [chemical binding]; other site 936157007706 MASE1; Region: MASE1; pfam05231 936157007707 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 936157007708 diguanylate cyclase; Region: GGDEF; smart00267 936157007709 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157007710 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 936157007711 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 936157007712 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 936157007713 GIY-YIG motif/motif A; other site 936157007714 putative active site [active] 936157007715 putative metal binding site [ion binding]; other site 936157007716 GMP synthase; Reviewed; Region: guaA; PRK00074 936157007717 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 936157007718 AMP/PPi binding site [chemical binding]; other site 936157007719 candidate oxyanion hole; other site 936157007720 catalytic triad [active] 936157007721 potential glutamine specificity residues [chemical binding]; other site 936157007722 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 936157007723 ATP Binding subdomain [chemical binding]; other site 936157007724 Ligand Binding sites [chemical binding]; other site 936157007725 Dimerization subdomain; other site 936157007726 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 936157007727 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 936157007728 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 936157007729 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 936157007730 active site 936157007731 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 936157007732 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 936157007733 generic binding surface II; other site 936157007734 generic binding surface I; other site 936157007735 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 936157007736 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 936157007737 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 936157007738 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 936157007739 Autotransporter beta-domain; Region: Autotransporter; smart00869 936157007740 Filamentous hemagglutinin;, autotrns_rpt: autotransporter-associated beta strand repeat, Autotransporter-associated beta strand repeat 936157007741 outer membrane protein RatB; Provisional; Region: PRK15314 936157007742 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007743 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007744 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007745 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007746 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007747 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007748 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007749 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007750 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007751 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007752 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007753 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007754 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007755 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007756 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007757 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007758 outer membrane protein RatA; Provisional; Region: PRK15315 936157007759 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007760 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007761 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007762 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007763 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007764 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007765 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007766 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007767 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007768 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 936157007769 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 936157007770 intimin-like protein SinH; Provisional; Region: PRK15318 936157007771 intimin-like protein SinH; Provisional; Region: PRK15318 936157007772 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 936157007773 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 936157007774 GTP-binding protein Der; Reviewed; Region: PRK00093 936157007775 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 936157007776 G1 box; other site 936157007777 GTP/Mg2+ binding site [chemical binding]; other site 936157007778 Switch I region; other site 936157007779 G2 box; other site 936157007780 Switch II region; other site 936157007781 G3 box; other site 936157007782 G4 box; other site 936157007783 G5 box; other site 936157007784 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 936157007785 G1 box; other site 936157007786 GTP/Mg2+ binding site [chemical binding]; other site 936157007787 Switch I region; other site 936157007788 G2 box; other site 936157007789 G3 box; other site 936157007790 Switch II region; other site 936157007791 G4 box; other site 936157007792 G5 box; other site 936157007793 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 936157007794 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 936157007795 Trp docking motif [polypeptide binding]; other site 936157007796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 936157007797 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 936157007798 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 936157007799 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 936157007800 dimer interface [polypeptide binding]; other site 936157007801 motif 1; other site 936157007802 active site 936157007803 motif 2; other site 936157007804 motif 3; other site 936157007805 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 936157007806 anticodon binding site; other site 936157007807 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 936157007808 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 936157007809 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 936157007810 cytoskeletal protein RodZ; Provisional; Region: PRK10856 936157007811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157007812 non-specific DNA binding site [nucleotide binding]; other site 936157007813 salt bridge; other site 936157007814 sequence-specific DNA binding site [nucleotide binding]; other site 936157007815 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 936157007816 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 936157007817 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157007818 FeS/SAM binding site; other site 936157007819 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 936157007820 active site 936157007821 multimer interface [polypeptide binding]; other site 936157007822 4Fe-4S binding domain; Region: Fer4; pfam00037 936157007823 hydrogenase 4 subunit H; Validated; Region: PRK08222 936157007824 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 936157007825 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 936157007826 4Fe-4S binding domain; Region: Fer4; pfam00037 936157007827 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 936157007828 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 936157007829 putative [Fe4-S4] binding site [ion binding]; other site 936157007830 putative molybdopterin cofactor binding site [chemical binding]; other site 936157007831 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 936157007832 putative molybdopterin cofactor binding site; other site 936157007833 penicillin-binding protein 1C; Provisional; Region: PRK11240 936157007834 Transglycosylase; Region: Transgly; pfam00912 936157007835 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 936157007836 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 936157007837 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 936157007838 MG2 domain; Region: A2M_N; pfam01835 936157007839 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 936157007840 surface patch; other site 936157007841 thioester region; other site 936157007842 specificity defining residues; other site 936157007843 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 936157007844 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 936157007845 active site residue [active] 936157007846 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 936157007847 active site residue [active] 936157007848 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 936157007849 aminopeptidase B; Provisional; Region: PRK05015 936157007850 Peptidase; Region: DUF3663; pfam12404 936157007851 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 936157007852 interface (dimer of trimers) [polypeptide binding]; other site 936157007853 Substrate-binding/catalytic site; other site 936157007854 Zn-binding sites [ion binding]; other site 936157007855 hypothetical protein; Provisional; Region: PRK10721 936157007856 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 936157007857 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 936157007858 catalytic loop [active] 936157007859 iron binding site [ion binding]; other site 936157007860 chaperone protein HscA; Provisional; Region: hscA; PRK05183 936157007861 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 936157007862 nucleotide binding site [chemical binding]; other site 936157007863 putative NEF/HSP70 interaction site [polypeptide binding]; other site 936157007864 SBD interface [polypeptide binding]; other site 936157007865 co-chaperone HscB; Provisional; Region: hscB; PRK05014 936157007866 DnaJ domain; Region: DnaJ; pfam00226 936157007867 HSP70 interaction site [polypeptide binding]; other site 936157007868 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 936157007869 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 936157007870 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 936157007871 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 936157007872 trimerization site [polypeptide binding]; other site 936157007873 active site 936157007874 cysteine desulfurase; Provisional; Region: PRK14012 936157007875 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 936157007876 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936157007877 catalytic residue [active] 936157007878 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 936157007879 Rrf2 family protein; Region: rrf2_super; TIGR00738 936157007880 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 936157007881 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 936157007882 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 936157007883 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 936157007884 active site 936157007885 dimerization interface [polypeptide binding]; other site 936157007886 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 936157007887 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 936157007888 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 936157007889 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936157007890 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 936157007891 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 936157007892 FAD binding pocket [chemical binding]; other site 936157007893 FAD binding motif [chemical binding]; other site 936157007894 phosphate binding motif [ion binding]; other site 936157007895 beta-alpha-beta structure motif; other site 936157007896 NAD binding pocket [chemical binding]; other site 936157007897 Iron coordination center [ion binding]; other site 936157007898 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 936157007899 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 936157007900 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936157007901 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 936157007902 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 936157007903 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 936157007904 PRD domain; Region: PRD; pfam00874 936157007905 PRD domain; Region: PRD; pfam00874 936157007906 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 936157007907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157007908 putative substrate translocation pore; other site 936157007909 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 936157007910 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 936157007911 dimer interface [polypeptide binding]; other site 936157007912 active site 936157007913 glycine-pyridoxal phosphate binding site [chemical binding]; other site 936157007914 folate binding site [chemical binding]; other site 936157007915 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 936157007916 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 936157007917 heme-binding site [chemical binding]; other site 936157007918 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 936157007919 FAD binding pocket [chemical binding]; other site 936157007920 FAD binding motif [chemical binding]; other site 936157007921 phosphate binding motif [ion binding]; other site 936157007922 beta-alpha-beta structure motif; other site 936157007923 NAD binding pocket [chemical binding]; other site 936157007924 Heme binding pocket [chemical binding]; other site 936157007925 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 936157007926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157007927 DNA binding site [nucleotide binding] 936157007928 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 936157007929 lysine decarboxylase CadA; Provisional; Region: PRK15400 936157007930 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 936157007931 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 936157007932 homodimer interface [polypeptide binding]; other site 936157007933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157007934 catalytic residue [active] 936157007935 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 936157007936 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 936157007937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157007938 putative substrate translocation pore; other site 936157007939 POT family; Region: PTR2; pfam00854 936157007940 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 936157007941 Nitrogen regulatory protein P-II; Region: P-II; smart00938 936157007942 response regulator GlrR; Provisional; Region: PRK15115 936157007943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157007944 active site 936157007945 phosphorylation site [posttranslational modification] 936157007946 intermolecular recognition site; other site 936157007947 dimerization interface [polypeptide binding]; other site 936157007948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157007949 Walker A motif; other site 936157007950 ATP binding site [chemical binding]; other site 936157007951 Walker B motif; other site 936157007952 arginine finger; other site 936157007953 hypothetical protein; Provisional; Region: PRK10722 936157007954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936157007955 HAMP domain; Region: HAMP; pfam00672 936157007956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157007957 dimer interface [polypeptide binding]; other site 936157007958 phosphorylation site [posttranslational modification] 936157007959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157007960 ATP binding site [chemical binding]; other site 936157007961 Mg2+ binding site [ion binding]; other site 936157007962 G-X-G motif; other site 936157007963 Integrase core domain; Region: rve; pfam00665 936157007964 Integrase core domain; Region: rve_3; pfam13683 936157007965 Helix-turn-helix domain; Region: HTH_28; pfam13518 936157007966 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 936157007967 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 936157007968 dimerization interface [polypeptide binding]; other site 936157007969 ATP binding site [chemical binding]; other site 936157007970 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 936157007971 dimerization interface [polypeptide binding]; other site 936157007972 ATP binding site [chemical binding]; other site 936157007973 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 936157007974 putative active site [active] 936157007975 catalytic triad [active] 936157007976 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 936157007977 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157007978 substrate binding pocket [chemical binding]; other site 936157007979 membrane-bound complex binding site; other site 936157007980 hinge residues; other site 936157007981 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936157007982 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936157007983 catalytic residue [active] 936157007984 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 936157007985 nucleoside/Zn binding site; other site 936157007986 dimer interface [polypeptide binding]; other site 936157007987 catalytic motif [active] 936157007988 hypothetical protein; Provisional; Region: PRK11590 936157007989 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 936157007990 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 936157007991 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936157007992 active site turn [active] 936157007993 phosphorylation site [posttranslational modification] 936157007994 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936157007995 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 936157007996 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 936157007997 putative active site [active] 936157007998 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 936157007999 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 936157008000 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 936157008001 putative active site [active] 936157008002 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 936157008003 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 936157008004 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 936157008005 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 936157008006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157008007 putative substrate translocation pore; other site 936157008008 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157008009 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157008010 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936157008011 dimerization interface [polypeptide binding]; other site 936157008012 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 936157008013 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 936157008014 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 936157008015 active site 936157008016 hydrophilic channel; other site 936157008017 dimerization interface [polypeptide binding]; other site 936157008018 catalytic residues [active] 936157008019 active site lid [active] 936157008020 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 936157008021 Recombination protein O N terminal; Region: RecO_N; pfam11967 936157008022 Recombination protein O C terminal; Region: RecO_C; pfam02565 936157008023 GTPase Era; Reviewed; Region: era; PRK00089 936157008024 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 936157008025 G1 box; other site 936157008026 GTP/Mg2+ binding site [chemical binding]; other site 936157008027 Switch I region; other site 936157008028 G2 box; other site 936157008029 Switch II region; other site 936157008030 G3 box; other site 936157008031 G4 box; other site 936157008032 G5 box; other site 936157008033 KH domain; Region: KH_2; pfam07650 936157008034 ribonuclease III; Reviewed; Region: rnc; PRK00102 936157008035 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 936157008036 dimerization interface [polypeptide binding]; other site 936157008037 active site 936157008038 metal binding site [ion binding]; metal-binding site 936157008039 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 936157008040 dsRNA binding site [nucleotide binding]; other site 936157008041 signal peptidase I; Provisional; Region: PRK10861 936157008042 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 936157008043 Catalytic site [active] 936157008044 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 936157008045 GTP-binding protein LepA; Provisional; Region: PRK05433 936157008046 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 936157008047 G1 box; other site 936157008048 putative GEF interaction site [polypeptide binding]; other site 936157008049 GTP/Mg2+ binding site [chemical binding]; other site 936157008050 Switch I region; other site 936157008051 G2 box; other site 936157008052 G3 box; other site 936157008053 Switch II region; other site 936157008054 G4 box; other site 936157008055 G5 box; other site 936157008056 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 936157008057 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 936157008058 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 936157008059 type III secretion protein GogB; Provisional; Region: PRK15386 936157008060 Integrase core domain; Region: rve_3; cl15866 936157008061 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 936157008062 Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900 936157008063 ADP-ribose binding site [chemical binding]; other site 936157008064 putative active site [active] 936157008065 dimer interface [polypeptide binding]; other site 936157008066 Phage Tail Collar Domain; Region: Collar; pfam07484 936157008067 protein disaggregation chaperone; Provisional; Region: PRK10865 936157008068 Clp amino terminal domain; Region: Clp_N; pfam02861 936157008069 Clp amino terminal domain; Region: Clp_N; pfam02861 936157008070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157008071 Walker A motif; other site 936157008072 ATP binding site [chemical binding]; other site 936157008073 Walker B motif; other site 936157008074 arginine finger; other site 936157008075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157008076 Walker A motif; other site 936157008077 ATP binding site [chemical binding]; other site 936157008078 Walker B motif; other site 936157008079 arginine finger; other site 936157008080 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 936157008081 hypothetical protein; Provisional; Region: PRK10723 936157008082 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 936157008083 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 936157008084 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936157008085 RNA binding surface [nucleotide binding]; other site 936157008086 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 936157008087 active site 936157008088 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 936157008089 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 936157008090 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 936157008091 30S subunit binding site; other site 936157008092 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 936157008093 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 936157008094 Prephenate dehydratase; Region: PDT; pfam00800 936157008095 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 936157008096 putative L-Phe binding site [chemical binding]; other site 936157008097 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 936157008098 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 936157008099 Chorismate mutase type II; Region: CM_2; cl00693 936157008100 prephenate dehydrogenase; Validated; Region: PRK08507 936157008101 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 936157008102 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 936157008103 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 936157008104 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 936157008105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936157008106 metal binding site [ion binding]; metal-binding site 936157008107 active site 936157008108 I-site; other site 936157008109 integrase; Provisional; Region: int; PHA02601 936157008110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 936157008111 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 936157008112 active site 936157008113 DNA binding site [nucleotide binding] 936157008114 Int/Topo IB signature motif; other site 936157008115 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 936157008116 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 936157008117 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 936157008118 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 936157008119 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 936157008120 DksA-like zinc finger domain containing protein; Region: PHA00080 936157008121 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 936157008122 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 936157008123 active site 936157008124 catalytic site [active] 936157008125 substrate binding site [chemical binding]; other site 936157008126 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 936157008127 DinI-like family; Region: DinI; pfam06183 936157008128 portal vertex protein; Provisional; Region: Q; PHA02536 936157008129 Phage portal protein; Region: Phage_portal; pfam04860 936157008130 terminase ATPase subunit; Provisional; Region: P; PHA02535 936157008131 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 936157008132 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 936157008133 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 936157008134 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 936157008135 terminase endonuclease subunit; Provisional; Region: M; PHA02537 936157008136 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 936157008137 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 936157008138 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 936157008139 Phage holin family 2; Region: Phage_holin_2; pfam04550 936157008140 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 936157008141 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936157008142 catalytic residue [active] 936157008143 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 936157008144 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 936157008145 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 936157008146 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 936157008147 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 936157008148 baseplate wedge subunit; Provisional; Region: W; PHA02516 936157008149 baseplate assembly protein; Provisional; Region: J; PHA02568 936157008150 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 936157008151 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 936157008152 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 936157008153 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 936157008154 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 936157008155 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 936157008156 major tail sheath protein; Provisional; Region: FI; PHA02560 936157008157 major tail tube protein; Provisional; Region: FII; PHA02600 936157008158 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 936157008159 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 936157008160 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 936157008161 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 936157008162 Phage-related tail protein [Function unknown]; Region: COG5283 936157008163 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 936157008164 tail protein; Provisional; Region: D; PHA02561 936157008165 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 936157008166 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 936157008167 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 936157008168 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 936157008169 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 936157008170 RimM N-terminal domain; Region: RimM; pfam01782 936157008171 PRC-barrel domain; Region: PRC; pfam05239 936157008172 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 936157008173 signal recognition particle protein; Provisional; Region: PRK10867 936157008174 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 936157008175 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 936157008176 P loop; other site 936157008177 GTP binding site [chemical binding]; other site 936157008178 Signal peptide binding domain; Region: SRP_SPB; pfam02978 936157008179 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 936157008180 hypothetical protein; Provisional; Region: PRK11573 936157008181 Domain of unknown function DUF21; Region: DUF21; pfam01595 936157008182 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 936157008183 Transporter associated domain; Region: CorC_HlyC; smart01091 936157008184 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 936157008185 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 936157008186 dimer interface [polypeptide binding]; other site 936157008187 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 936157008188 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 936157008189 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 936157008190 recombination and repair protein; Provisional; Region: PRK10869 936157008191 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 936157008192 Walker A/P-loop; other site 936157008193 ATP binding site [chemical binding]; other site 936157008194 Q-loop/lid; other site 936157008195 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 936157008196 ABC transporter signature motif; other site 936157008197 Walker B; other site 936157008198 D-loop; other site 936157008199 H-loop/switch region; other site 936157008200 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 936157008201 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 936157008202 hypothetical protein; Validated; Region: PRK01777 936157008203 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 936157008204 putative coenzyme Q binding site [chemical binding]; other site 936157008205 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 936157008206 SmpB-tmRNA interface; other site 936157008207 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008208 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008209 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008210 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008211 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008212 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008213 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008214 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008215 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008216 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008217 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008218 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008219 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 936157008220 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008221 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157008222 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 936157008223 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 936157008224 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 936157008225 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936157008226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157008227 Walker A/P-loop; other site 936157008228 ATP binding site [chemical binding]; other site 936157008229 Q-loop/lid; other site 936157008230 ABC transporter signature motif; other site 936157008231 Walker B; other site 936157008232 D-loop; other site 936157008233 H-loop/switch region; other site 936157008234 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 936157008235 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157008236 flagellin; Validated; Region: PRK08026 936157008237 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 936157008238 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 936157008239 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 936157008240 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 936157008241 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 936157008242 catalytic residues [active] 936157008243 catalytic nucleophile [active] 936157008244 Presynaptic Site I dimer interface [polypeptide binding]; other site 936157008245 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 936157008246 Synaptic Flat tetramer interface [polypeptide binding]; other site 936157008247 Synaptic Site I dimer interface [polypeptide binding]; other site 936157008248 DNA binding site [nucleotide binding] 936157008249 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 936157008250 DNA-binding interface [nucleotide binding]; DNA binding site 936157008251 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 936157008252 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 936157008253 homodimer interface [polypeptide binding]; other site 936157008254 active site 936157008255 TDP-binding site; other site 936157008256 acceptor substrate-binding pocket; other site 936157008257 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936157008258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157008259 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 936157008260 Walker A/P-loop; other site 936157008261 ATP binding site [chemical binding]; other site 936157008262 Q-loop/lid; other site 936157008263 ABC transporter signature motif; other site 936157008264 Walker B; other site 936157008265 D-loop; other site 936157008266 H-loop/switch region; other site 936157008267 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 936157008268 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 936157008269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157008270 Walker A/P-loop; other site 936157008271 ATP binding site [chemical binding]; other site 936157008272 Q-loop/lid; other site 936157008273 ABC transporter signature motif; other site 936157008274 Walker B; other site 936157008275 D-loop; other site 936157008276 H-loop/switch region; other site 936157008277 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 936157008278 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 936157008279 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 936157008280 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 936157008281 outer membrane receptor FepA; Provisional; Region: PRK13528 936157008282 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 936157008283 N-terminal plug; other site 936157008284 ligand-binding site [chemical binding]; other site 936157008285 secreted effector protein PipB2; Provisional; Region: PRK15196 936157008286 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 936157008287 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 936157008288 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 936157008289 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 936157008290 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 936157008291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 936157008292 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 936157008293 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 936157008294 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 936157008295 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 936157008296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 936157008297 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 936157008298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157008299 dimer interface [polypeptide binding]; other site 936157008300 phosphorylation site [posttranslational modification] 936157008301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157008302 ATP binding site [chemical binding]; other site 936157008303 Mg2+ binding site [ion binding]; other site 936157008304 G-X-G motif; other site 936157008305 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 936157008306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157008307 active site 936157008308 phosphorylation site [posttranslational modification] 936157008309 intermolecular recognition site; other site 936157008310 dimerization interface [polypeptide binding]; other site 936157008311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157008312 DNA binding site [nucleotide binding] 936157008313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 936157008314 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 936157008315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 936157008316 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 936157008317 substrate binding pocket [chemical binding]; other site 936157008318 active site 936157008319 iron coordination sites [ion binding]; other site 936157008320 Predicted dehydrogenase [General function prediction only]; Region: COG0579 936157008321 hydroxyglutarate oxidase; Provisional; Region: PRK11728 936157008322 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 936157008323 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 936157008324 tetramerization interface [polypeptide binding]; other site 936157008325 NAD(P) binding site [chemical binding]; other site 936157008326 catalytic residues [active] 936157008327 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 936157008328 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936157008329 inhibitor-cofactor binding pocket; inhibition site 936157008330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157008331 catalytic residue [active] 936157008332 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 936157008333 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 936157008334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157008335 DNA-binding site [nucleotide binding]; DNA binding site 936157008336 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 936157008337 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 936157008338 bacterial OsmY and nodulation domain; Region: BON; smart00749 936157008339 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936157008340 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 936157008341 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936157008342 dimerization interface [polypeptide binding]; other site 936157008343 putative DNA binding site [nucleotide binding]; other site 936157008344 putative Zn2+ binding site [ion binding]; other site 936157008345 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 936157008346 active site residue [active] 936157008347 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 936157008348 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 936157008349 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 936157008350 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 936157008351 hypothetical protein; Provisional; Region: PRK10556 936157008352 hypothetical protein; Provisional; Region: PRK10132 936157008353 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 936157008354 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157008355 DNA-binding site [nucleotide binding]; DNA binding site 936157008356 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936157008357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157008358 homodimer interface [polypeptide binding]; other site 936157008359 catalytic residue [active] 936157008360 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 936157008361 Uncharacterized conserved protein [Function unknown]; Region: COG2128 936157008362 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 936157008363 catalytic residues [active] 936157008364 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 936157008365 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 936157008366 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 936157008367 Class I ribonucleotide reductase; Region: RNR_I; cd01679 936157008368 active site 936157008369 dimer interface [polypeptide binding]; other site 936157008370 catalytic residues [active] 936157008371 effector binding site; other site 936157008372 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 936157008373 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 936157008374 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 936157008375 dimer interface [polypeptide binding]; other site 936157008376 putative radical transfer pathway; other site 936157008377 diiron center [ion binding]; other site 936157008378 tyrosyl radical; other site 936157008379 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 936157008380 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 936157008381 Walker A/P-loop; other site 936157008382 ATP binding site [chemical binding]; other site 936157008383 Q-loop/lid; other site 936157008384 ABC transporter signature motif; other site 936157008385 Walker B; other site 936157008386 D-loop; other site 936157008387 H-loop/switch region; other site 936157008388 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 936157008389 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 936157008390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157008391 dimer interface [polypeptide binding]; other site 936157008392 conserved gate region; other site 936157008393 putative PBP binding loops; other site 936157008394 ABC-ATPase subunit interface; other site 936157008395 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 936157008396 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 936157008397 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 936157008398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157008399 transcriptional repressor MprA; Provisional; Region: PRK10870 936157008400 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 936157008401 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 936157008402 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936157008403 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157008404 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 936157008405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157008406 putative substrate translocation pore; other site 936157008407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157008408 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 936157008409 S-ribosylhomocysteinase; Provisional; Region: PRK02260 936157008410 glutamate--cysteine ligase; Provisional; Region: PRK02107 936157008411 Predicted membrane protein [Function unknown]; Region: COG1238 936157008412 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 936157008413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157008414 motif II; other site 936157008415 carbon storage regulator; Provisional; Region: PRK01712 936157008416 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 936157008417 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 936157008418 motif 1; other site 936157008419 active site 936157008420 motif 2; other site 936157008421 motif 3; other site 936157008422 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 936157008423 DHHA1 domain; Region: DHHA1; pfam02272 936157008424 recombination regulator RecX; Reviewed; Region: recX; PRK00117 936157008425 recombinase A; Provisional; Region: recA; PRK09354 936157008426 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 936157008427 hexamer interface [polypeptide binding]; other site 936157008428 Walker A motif; other site 936157008429 ATP binding site [chemical binding]; other site 936157008430 Walker B motif; other site 936157008431 hypothetical protein; Validated; Region: PRK03661 936157008432 Transglycosylase SLT domain; Region: SLT_2; pfam13406 936157008433 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936157008434 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936157008435 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 936157008436 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 936157008437 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 936157008438 Nucleoside recognition; Region: Gate; pfam07670 936157008439 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 936157008440 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 936157008441 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 936157008442 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 936157008443 putative NAD(P) binding site [chemical binding]; other site 936157008444 active site 936157008445 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 936157008446 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 936157008447 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 936157008448 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157008449 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 936157008450 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 936157008451 putative active site [active] 936157008452 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 936157008453 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 936157008454 GAF domain; Region: GAF; pfam01590 936157008455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157008456 Walker A motif; other site 936157008457 ATP binding site [chemical binding]; other site 936157008458 Walker B motif; other site 936157008459 arginine finger; other site 936157008460 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 936157008461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 936157008462 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 936157008463 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 936157008464 iron binding site [ion binding]; other site 936157008465 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 936157008466 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936157008467 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936157008468 Acylphosphatase; Region: Acylphosphatase; pfam00708 936157008469 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 936157008470 HypF finger; Region: zf-HYPF; pfam07503 936157008471 HypF finger; Region: zf-HYPF; pfam07503 936157008472 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 936157008473 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 936157008474 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 936157008475 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 936157008476 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 936157008477 nickel binding site [ion binding]; other site 936157008478 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 936157008479 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 936157008480 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 936157008481 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 936157008482 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 936157008483 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 936157008484 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 936157008485 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 936157008486 NADH dehydrogenase; Region: NADHdh; cl00469 936157008487 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 936157008488 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 936157008489 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 936157008490 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 936157008491 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 936157008492 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 936157008493 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 936157008494 hydrogenase assembly chaperone; Provisional; Region: PRK10409 936157008495 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 936157008496 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 936157008497 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 936157008498 dimerization interface [polypeptide binding]; other site 936157008499 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 936157008500 ATP binding site [chemical binding]; other site 936157008501 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 936157008502 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 936157008503 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 936157008504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157008505 Walker A motif; other site 936157008506 ATP binding site [chemical binding]; other site 936157008507 Walker B motif; other site 936157008508 arginine finger; other site 936157008509 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 936157008510 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 936157008511 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 936157008512 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 936157008513 metal binding site [ion binding]; metal-binding site 936157008514 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 936157008515 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 936157008516 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 936157008517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936157008518 ABC-ATPase subunit interface; other site 936157008519 dimer interface [polypeptide binding]; other site 936157008520 putative PBP binding regions; other site 936157008521 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 936157008522 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 936157008523 ABC-ATPase subunit interface; other site 936157008524 dimer interface [polypeptide binding]; other site 936157008525 effector protein YopJ; Provisional; Region: PRK15371 936157008526 transcriptional activator SprB; Provisional; Region: PRK15320 936157008527 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 936157008528 transcriptional regulator SirC; Provisional; Region: PRK15044 936157008529 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157008530 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 936157008531 invasion protein OrgB; Provisional; Region: PRK15322 936157008532 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 936157008533 invasion protein OrgA; Provisional; Region: PRK15323 936157008534 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 936157008535 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 936157008536 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 936157008537 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 936157008538 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 936157008539 transcriptional regulator HilD; Provisional; Region: PRK15185 936157008540 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157008541 invasion protein regulator; Provisional; Region: PRK12370 936157008542 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157008543 DNA binding site [nucleotide binding] 936157008544 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936157008545 binding surface 936157008546 TPR motif; other site 936157008547 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 936157008548 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936157008549 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936157008550 catalytic residue [active] 936157008551 pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375 936157008552 SicP binding; Region: SicP-binding; pfam09119 936157008553 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 936157008554 switch II binding region; other site 936157008555 Rac1 P-loop interaction site [polypeptide binding]; other site 936157008556 GTP binding residues [chemical binding]; other site 936157008557 switch I binding region; other site 936157008558 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 936157008559 active site 936157008560 chaperone protein SicP; Provisional; Region: PRK15329 936157008561 putative acyl carrier protein IacP; Validated; Region: PRK08172 936157008562 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 936157008563 cell invasion protein SipD; Provisional; Region: PRK15330 936157008564 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 936157008565 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 936157008566 chaperone protein SicA; Provisional; Region: PRK15331 936157008567 Tetratricopeptide repeat; Region: TPR_3; pfam07720 936157008568 Tetratricopeptide repeat; Region: TPR_3; pfam07720 936157008569 type III secretion system protein SpaS; Validated; Region: PRK08156 936157008570 type III secretion system protein SpaR; Provisional; Region: PRK15332 936157008571 type III secretion system protein SpaQ; Provisional; Region: PRK15333 936157008572 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 936157008573 type III secretion system protein SpaO; Validated; Region: PRK08158 936157008574 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 936157008575 antigen presentation protein SpaN; Provisional; Region: PRK15334 936157008576 Surface presentation of antigens protein; Region: SPAN; pfam02510 936157008577 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 936157008578 ATP synthase SpaL; Validated; Region: PRK08149 936157008579 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 936157008580 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 936157008581 Walker A motif; other site 936157008582 ATP binding site [chemical binding]; other site 936157008583 Walker B motif; other site 936157008584 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 936157008585 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 936157008586 type III secretion system protein InvA; Provisional; Region: PRK15337 936157008587 type III secretion system regulator InvE; Provisional; Region: PRK15338 936157008588 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 936157008589 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 936157008590 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 936157008591 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 936157008592 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 936157008593 transcriptional regulator InvF; Provisional; Region: PRK15340 936157008594 InvH outer membrane lipoprotein; Region: InvH; pfam04741 936157008595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 936157008596 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 936157008597 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 936157008598 active site 936157008599 metal binding site [ion binding]; metal-binding site 936157008600 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 936157008601 MutS domain I; Region: MutS_I; pfam01624 936157008602 MutS domain II; Region: MutS_II; pfam05188 936157008603 MutS domain III; Region: MutS_III; pfam05192 936157008604 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 936157008605 Walker A/P-loop; other site 936157008606 ATP binding site [chemical binding]; other site 936157008607 Q-loop/lid; other site 936157008608 ABC transporter signature motif; other site 936157008609 Walker B; other site 936157008610 D-loop; other site 936157008611 H-loop/switch region; other site 936157008612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 936157008613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157008614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936157008615 putative substrate translocation pore; other site 936157008616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157008617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157008618 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 936157008619 putative effector binding pocket; other site 936157008620 dimerization interface [polypeptide binding]; other site 936157008621 GntP family permease; Region: GntP_permease; pfam02447 936157008622 fructuronate transporter; Provisional; Region: PRK10034; cl15264 936157008623 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 936157008624 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 936157008625 putative NAD(P) binding site [chemical binding]; other site 936157008626 active site 936157008627 putative substrate binding site [chemical binding]; other site 936157008628 hypothetical protein; Provisional; Region: PRK09989 936157008629 putative aldolase; Validated; Region: PRK08130 936157008630 intersubunit interface [polypeptide binding]; other site 936157008631 active site 936157008632 Zn2+ binding site [ion binding]; other site 936157008633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 936157008634 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 936157008635 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 936157008636 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936157008637 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 936157008638 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157008639 MarR family; Region: MarR_2; cl17246 936157008640 Transcriptional regulators [Transcription]; Region: MarR; COG1846 936157008641 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 936157008642 Flavoprotein; Region: Flavoprotein; pfam02441 936157008643 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 936157008644 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 936157008645 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 936157008646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936157008647 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 936157008648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936157008649 DNA binding residues [nucleotide binding] 936157008650 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 936157008651 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936157008652 Peptidase family M23; Region: Peptidase_M23; pfam01551 936157008653 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 936157008654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157008655 S-adenosylmethionine binding site [chemical binding]; other site 936157008656 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 936157008657 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 936157008658 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 936157008659 Permutation of conserved domain; other site 936157008660 active site 936157008661 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 936157008662 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 936157008663 homotrimer interaction site [polypeptide binding]; other site 936157008664 zinc binding site [ion binding]; other site 936157008665 CDP-binding sites; other site 936157008666 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 936157008667 substrate binding site; other site 936157008668 dimer interface; other site 936157008669 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 936157008670 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 936157008671 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 936157008672 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 936157008673 ligand-binding site [chemical binding]; other site 936157008674 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 936157008675 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 936157008676 CysD dimerization site [polypeptide binding]; other site 936157008677 G1 box; other site 936157008678 putative GEF interaction site [polypeptide binding]; other site 936157008679 GTP/Mg2+ binding site [chemical binding]; other site 936157008680 Switch I region; other site 936157008681 G2 box; other site 936157008682 G3 box; other site 936157008683 Switch II region; other site 936157008684 G4 box; other site 936157008685 G5 box; other site 936157008686 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 936157008687 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 936157008688 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 936157008689 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 936157008690 Active Sites [active] 936157008691 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 936157008692 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 936157008693 metal binding site [ion binding]; metal-binding site 936157008694 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 936157008695 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 936157008696 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 936157008697 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 936157008698 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 936157008699 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 936157008700 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 936157008701 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 936157008702 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 936157008703 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 936157008704 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 936157008705 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 936157008706 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 936157008707 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 936157008708 Active Sites [active] 936157008709 sulfite reductase subunit beta; Provisional; Region: PRK13504 936157008710 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 936157008711 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 936157008712 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 936157008713 Flavodoxin; Region: Flavodoxin_1; pfam00258 936157008714 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 936157008715 FAD binding pocket [chemical binding]; other site 936157008716 FAD binding motif [chemical binding]; other site 936157008717 catalytic residues [active] 936157008718 NAD binding pocket [chemical binding]; other site 936157008719 phosphate binding motif [ion binding]; other site 936157008720 beta-alpha-beta structure motif; other site 936157008721 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 936157008722 active site 936157008723 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 936157008724 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 936157008725 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 936157008726 enolase; Provisional; Region: eno; PRK00077 936157008727 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 936157008728 dimer interface [polypeptide binding]; other site 936157008729 metal binding site [ion binding]; metal-binding site 936157008730 substrate binding pocket [chemical binding]; other site 936157008731 CTP synthetase; Validated; Region: pyrG; PRK05380 936157008732 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 936157008733 Catalytic site [active] 936157008734 active site 936157008735 UTP binding site [chemical binding]; other site 936157008736 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 936157008737 active site 936157008738 putative oxyanion hole; other site 936157008739 catalytic triad [active] 936157008740 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 936157008741 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 936157008742 homodimer interface [polypeptide binding]; other site 936157008743 metal binding site [ion binding]; metal-binding site 936157008744 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 936157008745 homodimer interface [polypeptide binding]; other site 936157008746 active site 936157008747 putative chemical substrate binding site [chemical binding]; other site 936157008748 metal binding site [ion binding]; metal-binding site 936157008749 fimbrial protein SteA; Provisional; Region: PRK15261 936157008750 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 936157008751 PapC N-terminal domain; Region: PapC_N; pfam13954 936157008752 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 936157008753 PapC C-terminal domain; Region: PapC_C; pfam13953 936157008754 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 936157008755 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 936157008756 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 936157008757 putative fimbrial protein SteD; Provisional; Region: PRK15275 936157008758 putative fimbrial subunit SteE; Provisional; Region: PRK15276 936157008759 Fimbrial protein; Region: Fimbrial; cl01416 936157008760 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 936157008761 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 936157008762 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 936157008763 HD domain; Region: HD_4; pfam13328 936157008764 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 936157008765 synthetase active site [active] 936157008766 NTP binding site [chemical binding]; other site 936157008767 metal binding site [ion binding]; metal-binding site 936157008768 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 936157008769 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 936157008770 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 936157008771 TRAM domain; Region: TRAM; pfam01938 936157008772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157008773 S-adenosylmethionine binding site [chemical binding]; other site 936157008774 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 936157008775 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 936157008776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157008777 dimerization interface [polypeptide binding]; other site 936157008778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157008779 dimer interface [polypeptide binding]; other site 936157008780 phosphorylation site [posttranslational modification] 936157008781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157008782 ATP binding site [chemical binding]; other site 936157008783 Mg2+ binding site [ion binding]; other site 936157008784 G-X-G motif; other site 936157008785 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 936157008786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157008787 active site 936157008788 phosphorylation site [posttranslational modification] 936157008789 intermolecular recognition site; other site 936157008790 dimerization interface [polypeptide binding]; other site 936157008791 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 936157008792 putative binding surface; other site 936157008793 active site 936157008794 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 936157008795 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 936157008796 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 936157008797 active site 936157008798 tetramer interface [polypeptide binding]; other site 936157008799 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 936157008800 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 936157008801 active site 936157008802 tetramer interface [polypeptide binding]; other site 936157008803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157008804 D-galactonate transporter; Region: 2A0114; TIGR00893 936157008805 putative substrate translocation pore; other site 936157008806 flavodoxin; Provisional; Region: PRK08105 936157008807 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 936157008808 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 936157008809 probable active site [active] 936157008810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 936157008811 SecY interacting protein Syd; Provisional; Region: PRK04968 936157008812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 936157008813 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 936157008814 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 936157008815 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 936157008816 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 936157008817 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 936157008818 serine transporter; Region: stp; TIGR00814 936157008819 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 936157008820 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 936157008821 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 936157008822 flap endonuclease-like protein; Provisional; Region: PRK09482 936157008823 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 936157008824 active site 936157008825 metal binding site 1 [ion binding]; metal-binding site 936157008826 putative 5' ssDNA interaction site; other site 936157008827 metal binding site 3; metal-binding site 936157008828 metal binding site 2 [ion binding]; metal-binding site 936157008829 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 936157008830 putative DNA binding site [nucleotide binding]; other site 936157008831 putative metal binding site [ion binding]; other site 936157008832 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 936157008833 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 936157008834 dimer interface [polypeptide binding]; other site 936157008835 active site 936157008836 metal binding site [ion binding]; metal-binding site 936157008837 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 936157008838 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 936157008839 intersubunit interface [polypeptide binding]; other site 936157008840 active site 936157008841 Zn2+ binding site [ion binding]; other site 936157008842 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 936157008843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157008844 putative substrate translocation pore; other site 936157008845 L-fucose isomerase; Provisional; Region: fucI; PRK10991 936157008846 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 936157008847 hexamer (dimer of trimers) interface [polypeptide binding]; other site 936157008848 trimer interface [polypeptide binding]; other site 936157008849 substrate binding site [chemical binding]; other site 936157008850 Mn binding site [ion binding]; other site 936157008851 L-fuculokinase; Provisional; Region: PRK10331 936157008852 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 936157008853 nucleotide binding site [chemical binding]; other site 936157008854 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 936157008855 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 936157008856 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 936157008857 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157008858 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 936157008859 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 936157008860 hypothetical protein; Provisional; Region: PRK10873 936157008861 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 936157008862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157008863 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 936157008864 dimerization interface [polypeptide binding]; other site 936157008865 substrate binding pocket [chemical binding]; other site 936157008866 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 936157008867 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 936157008868 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 936157008869 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936157008870 catalytic residue [active] 936157008871 CsdA-binding activator; Provisional; Region: PRK15019 936157008872 Predicted permeases [General function prediction only]; Region: RarD; COG2962 936157008873 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 936157008874 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 936157008875 putative ATP binding site [chemical binding]; other site 936157008876 putative substrate interface [chemical binding]; other site 936157008877 murein transglycosylase A; Provisional; Region: mltA; PRK11162 936157008878 murein hydrolase B; Provisional; Region: PRK10760; cl17906 936157008879 MltA specific insert domain; Region: MltA; pfam03562 936157008880 3D domain; Region: 3D; pfam06725 936157008881 AMIN domain; Region: AMIN; pfam11741 936157008882 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 936157008883 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 936157008884 active site 936157008885 metal binding site [ion binding]; metal-binding site 936157008886 N-acetylglutamate synthase; Validated; Region: PRK05279 936157008887 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 936157008888 putative feedback inhibition sensing region; other site 936157008889 putative nucleotide binding site [chemical binding]; other site 936157008890 putative substrate binding site [chemical binding]; other site 936157008891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157008892 Coenzyme A binding pocket [chemical binding]; other site 936157008893 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 936157008894 AAA domain; Region: AAA_30; pfam13604 936157008895 Family description; Region: UvrD_C_2; pfam13538 936157008896 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 936157008897 protease3; Provisional; Region: PRK15101 936157008898 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 936157008899 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 936157008900 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 936157008901 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 936157008902 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 936157008903 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 936157008904 hypothetical protein; Provisional; Region: PRK10332 936157008905 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 936157008906 hypothetical protein; Provisional; Region: PRK11521 936157008907 hypothetical protein; Provisional; Region: PRK10557 936157008908 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 936157008909 hypothetical protein; Provisional; Region: PRK10506 936157008910 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 936157008911 thymidylate synthase; Reviewed; Region: thyA; PRK01827 936157008912 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 936157008913 dimerization interface [polypeptide binding]; other site 936157008914 active site 936157008915 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 936157008916 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 936157008917 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 936157008918 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 936157008919 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 936157008920 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 936157008921 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 936157008922 putative active site [active] 936157008923 Ap4A binding site [chemical binding]; other site 936157008924 nudix motif; other site 936157008925 putative metal binding site [ion binding]; other site 936157008926 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 936157008927 putative DNA-binding cleft [nucleotide binding]; other site 936157008928 putative DNA clevage site; other site 936157008929 molecular lever; other site 936157008930 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 936157008931 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 936157008932 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936157008933 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936157008934 active site 936157008935 catalytic tetrad [active] 936157008936 lysophospholipid transporter LplT; Provisional; Region: PRK11195 936157008937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157008938 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 936157008939 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 936157008940 putative acyl-acceptor binding pocket; other site 936157008941 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 936157008942 acyl-activating enzyme (AAE) consensus motif; other site 936157008943 putative AMP binding site [chemical binding]; other site 936157008944 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 936157008945 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157008946 DNA binding site [nucleotide binding] 936157008947 domain linker motif; other site 936157008948 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 936157008949 dimerization interface (closed form) [polypeptide binding]; other site 936157008950 ligand binding site [chemical binding]; other site 936157008951 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936157008952 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157008953 DNA binding site [nucleotide binding] 936157008954 domain linker motif; other site 936157008955 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 936157008956 dimerization interface (closed form) [polypeptide binding]; other site 936157008957 ligand binding site [chemical binding]; other site 936157008958 diaminopimelate decarboxylase; Provisional; Region: PRK11165 936157008959 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 936157008960 active site 936157008961 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936157008962 substrate binding site [chemical binding]; other site 936157008963 catalytic residues [active] 936157008964 dimer interface [polypeptide binding]; other site 936157008965 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 936157008966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157008967 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 936157008968 dimerization interface [polypeptide binding]; other site 936157008969 putative racemase; Provisional; Region: PRK10200 936157008970 aspartate racemase; Region: asp_race; TIGR00035 936157008971 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 936157008972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157008973 putative substrate translocation pore; other site 936157008974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157008975 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 936157008976 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 936157008977 NADP binding site [chemical binding]; other site 936157008978 homodimer interface [polypeptide binding]; other site 936157008979 active site 936157008980 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 936157008981 putative acyltransferase; Provisional; Region: PRK05790 936157008982 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 936157008983 dimer interface [polypeptide binding]; other site 936157008984 active site 936157008985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157008986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157008987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 936157008988 dimerization interface [polypeptide binding]; other site 936157008989 Predicted membrane protein [Function unknown]; Region: COG4125 936157008990 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 936157008991 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 936157008992 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 936157008993 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 936157008994 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 936157008995 putative metal binding site [ion binding]; other site 936157008996 putative homodimer interface [polypeptide binding]; other site 936157008997 putative homotetramer interface [polypeptide binding]; other site 936157008998 putative homodimer-homodimer interface [polypeptide binding]; other site 936157008999 putative allosteric switch controlling residues; other site 936157009000 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 936157009001 transcriptional activator SprB; Provisional; Region: PRK15320 936157009002 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 936157009003 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 936157009004 Fimbrial protein; Region: Fimbrial; pfam00419 936157009005 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 936157009006 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 936157009007 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 936157009008 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 936157009009 PapC C-terminal domain; Region: PapC_C; pfam13953 936157009010 PapC N-terminal domain; Region: PapC_N; pfam13954 936157009011 fimbrial protein StdA; Provisional; Region: PRK15210 936157009012 hypothetical protein; Provisional; Region: PRK10316 936157009013 YfdX protein; Region: YfdX; pfam10938 936157009014 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 936157009015 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 936157009016 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 936157009017 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 936157009018 Peptidase family M23; Region: Peptidase_M23; pfam01551 936157009019 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 936157009020 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 936157009021 active site 936157009022 metal binding site [ion binding]; metal-binding site 936157009023 nudix motif; other site 936157009024 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 936157009025 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 936157009026 dimer interface [polypeptide binding]; other site 936157009027 putative anticodon binding site; other site 936157009028 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 936157009029 motif 1; other site 936157009030 active site 936157009031 motif 2; other site 936157009032 motif 3; other site 936157009033 This domain is found in peptide chain release factors; Region: PCRF; smart00937 936157009034 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 936157009035 RF-1 domain; Region: RF-1; pfam00472 936157009036 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 936157009037 DHH family; Region: DHH; pfam01368 936157009038 DHHA1 domain; Region: DHHA1; pfam02272 936157009039 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 936157009040 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 936157009041 dimerization domain [polypeptide binding]; other site 936157009042 dimer interface [polypeptide binding]; other site 936157009043 catalytic residues [active] 936157009044 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 936157009045 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 936157009046 active site 936157009047 Int/Topo IB signature motif; other site 936157009048 flavodoxin FldB; Provisional; Region: PRK12359 936157009049 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 936157009050 hypothetical protein; Provisional; Region: PRK10878 936157009051 putative global regulator; Reviewed; Region: PRK09559 936157009052 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 936157009053 hemolysin; Provisional; Region: PRK15087 936157009054 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 936157009055 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 936157009056 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 936157009057 beta-galactosidase; Region: BGL; TIGR03356 936157009058 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 936157009059 glycine dehydrogenase; Provisional; Region: PRK05367 936157009060 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 936157009061 tetramer interface [polypeptide binding]; other site 936157009062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157009063 catalytic residue [active] 936157009064 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 936157009065 tetramer interface [polypeptide binding]; other site 936157009066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157009067 catalytic residue [active] 936157009068 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 936157009069 lipoyl attachment site [posttranslational modification]; other site 936157009070 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 936157009071 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 936157009072 oxidoreductase; Provisional; Region: PRK08013 936157009073 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 936157009074 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 936157009075 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 936157009076 proline aminopeptidase P II; Provisional; Region: PRK10879 936157009077 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 936157009078 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 936157009079 active site 936157009080 hypothetical protein; Reviewed; Region: PRK01736 936157009081 Z-ring-associated protein; Provisional; Region: PRK10972 936157009082 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 936157009083 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 936157009084 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 936157009085 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 936157009086 ligand binding site [chemical binding]; other site 936157009087 NAD binding site [chemical binding]; other site 936157009088 tetramer interface [polypeptide binding]; other site 936157009089 catalytic site [active] 936157009090 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 936157009091 L-serine binding site [chemical binding]; other site 936157009092 ACT domain interface; other site 936157009093 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 936157009094 tetramer (dimer of dimers) interface [polypeptide binding]; other site 936157009095 active site 936157009096 dimer interface [polypeptide binding]; other site 936157009097 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 936157009098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157009099 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 936157009100 putative dimerization interface [polypeptide binding]; other site 936157009101 Uncharacterized conserved protein [Function unknown]; Region: COG2968 936157009102 oxidative stress defense protein; Provisional; Region: PRK11087 936157009103 arginine exporter protein; Provisional; Region: PRK09304 936157009104 mechanosensitive channel MscS; Provisional; Region: PRK10334 936157009105 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936157009106 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 936157009107 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 936157009108 active site 936157009109 intersubunit interface [polypeptide binding]; other site 936157009110 zinc binding site [ion binding]; other site 936157009111 Na+ binding site [ion binding]; other site 936157009112 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 936157009113 Phosphoglycerate kinase; Region: PGK; pfam00162 936157009114 substrate binding site [chemical binding]; other site 936157009115 hinge regions; other site 936157009116 ADP binding site [chemical binding]; other site 936157009117 catalytic site [active] 936157009118 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 936157009119 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 936157009120 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 936157009121 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 936157009122 trimer interface [polypeptide binding]; other site 936157009123 putative Zn binding site [ion binding]; other site 936157009124 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 936157009125 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 936157009126 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 936157009127 Walker A/P-loop; other site 936157009128 ATP binding site [chemical binding]; other site 936157009129 Q-loop/lid; other site 936157009130 ABC transporter signature motif; other site 936157009131 Walker B; other site 936157009132 D-loop; other site 936157009133 H-loop/switch region; other site 936157009134 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 936157009135 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 936157009136 Walker A/P-loop; other site 936157009137 ATP binding site [chemical binding]; other site 936157009138 Q-loop/lid; other site 936157009139 ABC transporter signature motif; other site 936157009140 Walker B; other site 936157009141 D-loop; other site 936157009142 H-loop/switch region; other site 936157009143 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 936157009144 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 936157009145 active site 936157009146 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 936157009147 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 936157009148 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 936157009149 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 936157009150 putative active site [active] 936157009151 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 936157009152 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 936157009153 putative NAD(P) binding site [chemical binding]; other site 936157009154 catalytic Zn binding site [ion binding]; other site 936157009155 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 936157009156 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 936157009157 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 936157009158 active site 936157009159 P-loop; other site 936157009160 phosphorylation site [posttranslational modification] 936157009161 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936157009162 active site 936157009163 phosphorylation site [posttranslational modification] 936157009164 transketolase; Reviewed; Region: PRK12753 936157009165 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 936157009166 TPP-binding site [chemical binding]; other site 936157009167 dimer interface [polypeptide binding]; other site 936157009168 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 936157009169 PYR/PP interface [polypeptide binding]; other site 936157009170 dimer interface [polypeptide binding]; other site 936157009171 TPP binding site [chemical binding]; other site 936157009172 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 936157009173 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 936157009174 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 936157009175 agmatinase; Region: agmatinase; TIGR01230 936157009176 oligomer interface [polypeptide binding]; other site 936157009177 putative active site [active] 936157009178 Mn binding site [ion binding]; other site 936157009179 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 936157009180 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 936157009181 dimer interface [polypeptide binding]; other site 936157009182 active site 936157009183 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936157009184 catalytic residues [active] 936157009185 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 936157009186 Virulence promoting factor; Region: YqgB; pfam11036 936157009187 S-adenosylmethionine synthetase; Validated; Region: PRK05250 936157009188 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 936157009189 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 936157009190 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 936157009191 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 936157009192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157009193 putative substrate translocation pore; other site 936157009194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157009195 hypothetical protein; Provisional; Region: PRK04860 936157009196 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 936157009197 DNA-specific endonuclease I; Provisional; Region: PRK15137 936157009198 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 936157009199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 936157009200 RNA methyltransferase, RsmE family; Region: TIGR00046 936157009201 glutathione synthetase; Provisional; Region: PRK05246 936157009202 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 936157009203 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 936157009204 hypothetical protein; Validated; Region: PRK00228 936157009205 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 936157009206 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 936157009207 Transcriptional regulator [Transcription]; Region: IclR; COG1414 936157009208 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 936157009209 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 936157009210 Walker A motif; other site 936157009211 ATP binding site [chemical binding]; other site 936157009212 Walker B motif; other site 936157009213 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 936157009214 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936157009215 catalytic residue [active] 936157009216 YGGT family; Region: YGGT; pfam02325 936157009217 YGGT family; Region: YGGT; pfam02325 936157009218 hypothetical protein; Validated; Region: PRK05090 936157009219 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 936157009220 active site 936157009221 dimerization interface [polypeptide binding]; other site 936157009222 HemN family oxidoreductase; Provisional; Region: PRK05660 936157009223 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157009224 FeS/SAM binding site; other site 936157009225 HemN C-terminal domain; Region: HemN_C; pfam06969 936157009226 Uncharacterized protein yggM;, Protein of unknown function (DUF1202), Protein of unknown function DUF1202 936157009227 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 936157009228 homodimer interface [polypeptide binding]; other site 936157009229 active site 936157009230 hypothetical protein; Provisional; Region: PRK10626 936157009231 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 936157009232 hypothetical protein; Provisional; Region: PRK11702 936157009233 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 936157009234 adenine DNA glycosylase; Provisional; Region: PRK10880 936157009235 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 936157009236 minor groove reading motif; other site 936157009237 helix-hairpin-helix signature motif; other site 936157009238 substrate binding pocket [chemical binding]; other site 936157009239 active site 936157009240 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 936157009241 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 936157009242 DNA binding and oxoG recognition site [nucleotide binding] 936157009243 oxidative damage protection protein; Provisional; Region: PRK05408 936157009244 murein transglycosylase C; Provisional; Region: mltC; PRK11671 936157009245 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 936157009246 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936157009247 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936157009248 catalytic residue [active] 936157009249 nucleoside transporter; Region: 2A0110; TIGR00889 936157009250 ornithine decarboxylase; Provisional; Region: PRK13578 936157009251 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 936157009252 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 936157009253 homodimer interface [polypeptide binding]; other site 936157009254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157009255 catalytic residue [active] 936157009256 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 936157009257 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 936157009258 integrase; Provisional; Region: PRK09692 936157009259 LysR family transcriptional regulator; Provisional; Region: PRK14997 936157009260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157009261 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 936157009262 putative effector binding pocket; other site 936157009263 dimerization interface [polypeptide binding]; other site 936157009264 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 936157009265 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 936157009266 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 936157009267 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 936157009268 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 936157009269 FAD binding pocket [chemical binding]; other site 936157009270 FAD binding motif [chemical binding]; other site 936157009271 phosphate binding motif [ion binding]; other site 936157009272 beta-alpha-beta structure motif; other site 936157009273 NAD binding pocket [chemical binding]; other site 936157009274 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 936157009275 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 936157009276 Fic family protein [Function unknown]; Region: COG3177 936157009277 Fic/DOC family; Region: Fic; pfam02661 936157009278 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 936157009279 dimer interface [polypeptide binding]; other site 936157009280 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936157009281 metal binding site [ion binding]; metal-binding site 936157009282 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 936157009283 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 936157009284 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 936157009285 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 936157009286 putative active site [active] 936157009287 putative catalytic site [active] 936157009288 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 936157009289 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 936157009290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157009291 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 936157009292 putative dimerization interface [polypeptide binding]; other site 936157009293 putative substrate binding pocket [chemical binding]; other site 936157009294 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 936157009295 Sulfatase; Region: Sulfatase; pfam00884 936157009296 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 936157009297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157009298 FeS/SAM binding site; other site 936157009299 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 936157009300 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936157009301 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157009302 DNA binding residues [nucleotide binding] 936157009303 dimerization interface [polypeptide binding]; other site 936157009304 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 936157009305 Amino acid permease; Region: AA_permease_2; pfam13520 936157009306 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 936157009307 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 936157009308 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 936157009309 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 936157009310 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 936157009311 NAD(P) binding site [chemical binding]; other site 936157009312 catalytic residues [active] 936157009313 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 936157009314 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 936157009315 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 936157009316 active site 936157009317 catalytic site [active] 936157009318 Zn binding site [ion binding]; other site 936157009319 tetramer interface [polypeptide binding]; other site 936157009320 Predicted amidohydrolase [General function prediction only]; Region: COG0388 936157009321 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 936157009322 putative active site [active] 936157009323 catalytic triad [active] 936157009324 putative dimer interface [polypeptide binding]; other site 936157009325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157009326 D-galactonate transporter; Region: 2A0114; TIGR00893 936157009327 putative substrate translocation pore; other site 936157009328 mannonate dehydratase; Provisional; Region: PRK03906 936157009329 mannonate dehydratase; Region: uxuA; TIGR00695 936157009330 D-mannonate oxidoreductase; Provisional; Region: PRK15037 936157009331 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 936157009332 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 936157009333 Glucuronate isomerase; Region: UxaC; pfam02614 936157009334 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 936157009335 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936157009336 dimer interface [polypeptide binding]; other site 936157009337 putative CheW interface [polypeptide binding]; other site 936157009338 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 936157009339 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 936157009340 CHAP domain; Region: CHAP; pfam05257 936157009341 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 936157009342 putative S-transferase; Provisional; Region: PRK11752 936157009343 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 936157009344 C-terminal domain interface [polypeptide binding]; other site 936157009345 GSH binding site (G-site) [chemical binding]; other site 936157009346 dimer interface [polypeptide binding]; other site 936157009347 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 936157009348 dimer interface [polypeptide binding]; other site 936157009349 N-terminal domain interface [polypeptide binding]; other site 936157009350 active site 936157009351 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 936157009352 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 936157009353 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 936157009354 putative ligand binding residues [chemical binding]; other site 936157009355 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 936157009356 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 936157009357 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 936157009358 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 936157009359 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 936157009360 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 936157009361 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 936157009362 putative substrate-binding site; other site 936157009363 nickel binding site [ion binding]; other site 936157009364 hydrogenase 2 large subunit; Provisional; Region: PRK10467 936157009365 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 936157009366 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 936157009367 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 936157009368 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 936157009369 4Fe-4S binding domain; Region: Fer4_6; pfam12837 936157009370 hydrogenase 2 small subunit; Provisional; Region: PRK10468 936157009371 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 936157009372 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 936157009373 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 936157009374 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 936157009375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157009376 dimerization interface [polypeptide binding]; other site 936157009377 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936157009378 dimer interface [polypeptide binding]; other site 936157009379 putative CheW interface [polypeptide binding]; other site 936157009380 hypothetical protein; Provisional; Region: PRK05208 936157009381 oxidoreductase; Provisional; Region: PRK07985 936157009382 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 936157009383 NAD binding site [chemical binding]; other site 936157009384 metal binding site [ion binding]; metal-binding site 936157009385 active site 936157009386 biopolymer transport protein ExbD; Provisional; Region: PRK11267 936157009387 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 936157009388 biopolymer transport protein ExbB; Provisional; Region: PRK10414 936157009389 cystathionine beta-lyase; Provisional; Region: PRK08114 936157009390 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 936157009391 homodimer interface [polypeptide binding]; other site 936157009392 substrate-cofactor binding pocket; other site 936157009393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157009394 catalytic residue [active] 936157009395 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 936157009396 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 936157009397 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 936157009398 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 936157009399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157009400 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157009401 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 936157009402 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 936157009403 dimer interface [polypeptide binding]; other site 936157009404 active site 936157009405 metal binding site [ion binding]; metal-binding site 936157009406 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 936157009407 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 936157009408 active site 936157009409 catalytic tetrad [active] 936157009410 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 936157009411 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 936157009412 transmembrane helices; other site 936157009413 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 936157009414 nucleotide binding site/active site [active] 936157009415 catalytic residue [active] 936157009416 hypothetical protein; Provisional; Region: PRK01254 936157009417 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 936157009418 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 936157009419 YARHG domain; Region: YARHG; pfam13308 936157009420 FtsI repressor; Provisional; Region: PRK10883 936157009421 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 936157009422 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 936157009423 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 936157009424 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 936157009425 putative acyl-acceptor binding pocket; other site 936157009426 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 936157009427 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 936157009428 CAP-like domain; other site 936157009429 active site 936157009430 primary dimer interface [polypeptide binding]; other site 936157009431 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936157009432 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936157009433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157009434 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 936157009435 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 936157009436 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 936157009437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157009438 active site 936157009439 phosphorylation site [posttranslational modification] 936157009440 intermolecular recognition site; other site 936157009441 dimerization interface [polypeptide binding]; other site 936157009442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157009443 DNA binding site [nucleotide binding] 936157009444 sensor protein QseC; Provisional; Region: PRK10337 936157009445 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 936157009446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157009447 dimer interface [polypeptide binding]; other site 936157009448 phosphorylation site [posttranslational modification] 936157009449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157009450 ATP binding site [chemical binding]; other site 936157009451 Mg2+ binding site [ion binding]; other site 936157009452 G-X-G motif; other site 936157009453 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 936157009454 Uncharacterized conserved protein [Function unknown]; Region: COG1359 936157009455 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 936157009456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157009457 ATP binding site [chemical binding]; other site 936157009458 Mg2+ binding site [ion binding]; other site 936157009459 G-X-G motif; other site 936157009460 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 936157009461 anchoring element; other site 936157009462 dimer interface [polypeptide binding]; other site 936157009463 ATP binding site [chemical binding]; other site 936157009464 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 936157009465 active site 936157009466 metal binding site [ion binding]; metal-binding site 936157009467 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 936157009468 esterase YqiA; Provisional; Region: PRK11071 936157009469 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 936157009470 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 936157009471 active site 936157009472 metal binding site [ion binding]; metal-binding site 936157009473 hexamer interface [polypeptide binding]; other site 936157009474 putative dehydrogenase; Provisional; Region: PRK11039 936157009475 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 936157009476 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 936157009477 dimer interface [polypeptide binding]; other site 936157009478 ADP-ribose binding site [chemical binding]; other site 936157009479 active site 936157009480 nudix motif; other site 936157009481 metal binding site [ion binding]; metal-binding site 936157009482 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 936157009483 hypothetical protein; Provisional; Region: PRK11653 936157009484 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 936157009485 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 936157009486 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 936157009487 putative active site [active] 936157009488 metal binding site [ion binding]; metal-binding site 936157009489 zinc transporter ZupT; Provisional; Region: PRK04201 936157009490 ZIP Zinc transporter; Region: Zip; pfam02535 936157009491 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 936157009492 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 936157009493 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 936157009494 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 936157009495 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 936157009496 catalytic residues [active] 936157009497 hinge region; other site 936157009498 alpha helical domain; other site 936157009499 putative disulfide oxidoreductase; Provisional; Region: PRK04307 936157009500 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 936157009501 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 936157009502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 936157009503 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 936157009504 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 936157009505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 936157009506 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 936157009507 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 936157009508 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 936157009509 putative ribose interaction site [chemical binding]; other site 936157009510 putative ADP binding site [chemical binding]; other site 936157009511 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 936157009512 active site 936157009513 nucleotide binding site [chemical binding]; other site 936157009514 HIGH motif; other site 936157009515 KMSKS motif; other site 936157009516 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 936157009517 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 936157009518 metal binding triad; other site 936157009519 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 936157009520 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 936157009521 metal binding triad; other site 936157009522 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 936157009523 Uncharacterized conserved protein [Function unknown]; Region: COG3025 936157009524 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 936157009525 putative active site [active] 936157009526 putative metal binding residues [ion binding]; other site 936157009527 signature motif; other site 936157009528 putative triphosphate binding site [ion binding]; other site 936157009529 CHAD domain; Region: CHAD; cl10506 936157009530 SH3 domain-containing protein; Provisional; Region: PRK10884 936157009531 Bacterial SH3 domain homologues; Region: SH3b; smart00287 936157009532 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 936157009533 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 936157009534 active site 936157009535 NTP binding site [chemical binding]; other site 936157009536 metal binding triad [ion binding]; metal-binding site 936157009537 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 936157009538 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936157009539 Zn2+ binding site [ion binding]; other site 936157009540 Mg2+ binding site [ion binding]; other site 936157009541 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 936157009542 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 936157009543 homooctamer interface [polypeptide binding]; other site 936157009544 active site 936157009545 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 936157009546 UGMP family protein; Validated; Region: PRK09604 936157009547 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 936157009548 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 936157009549 DNA primase; Validated; Region: dnaG; PRK05667 936157009550 CHC2 zinc finger; Region: zf-CHC2; pfam01807 936157009551 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 936157009552 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 936157009553 active site 936157009554 metal binding site [ion binding]; metal-binding site 936157009555 interdomain interaction site; other site 936157009556 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 936157009557 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 936157009558 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 936157009559 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 936157009560 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 936157009561 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 936157009562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936157009563 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 936157009564 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936157009565 DNA binding residues [nucleotide binding] 936157009566 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 936157009567 active site 936157009568 SUMO-1 interface [polypeptide binding]; other site 936157009569 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 936157009570 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 936157009571 FAD binding pocket [chemical binding]; other site 936157009572 FAD binding motif [chemical binding]; other site 936157009573 phosphate binding motif [ion binding]; other site 936157009574 NAD binding pocket [chemical binding]; other site 936157009575 Predicted transcriptional regulators [Transcription]; Region: COG1695 936157009576 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 936157009577 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 936157009578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157009579 dimerization interface [polypeptide binding]; other site 936157009580 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936157009581 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936157009582 dimer interface [polypeptide binding]; other site 936157009583 putative CheW interface [polypeptide binding]; other site 936157009584 PAS fold; Region: PAS_3; pfam08447 936157009585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936157009586 putative active site [active] 936157009587 heme pocket [chemical binding]; other site 936157009588 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 936157009589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936157009590 dimer interface [polypeptide binding]; other site 936157009591 putative CheW interface [polypeptide binding]; other site 936157009592 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 936157009593 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936157009594 inhibitor-cofactor binding pocket; inhibition site 936157009595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157009596 catalytic residue [active] 936157009597 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 936157009598 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 936157009599 active site 936157009600 FMN binding site [chemical binding]; other site 936157009601 2,4-decadienoyl-CoA binding site; other site 936157009602 catalytic residue [active] 936157009603 4Fe-4S cluster binding site [ion binding]; other site 936157009604 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 936157009605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936157009606 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 936157009607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157009608 S-adenosylmethionine binding site [chemical binding]; other site 936157009609 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 936157009610 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 936157009611 putative active site [active] 936157009612 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936157009613 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936157009614 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 936157009615 serine/threonine transporter SstT; Provisional; Region: PRK13628 936157009616 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 936157009617 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 936157009618 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 936157009619 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 936157009620 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 936157009621 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 936157009622 Predicted membrane protein [Function unknown]; Region: COG5393 936157009623 YqjK-like protein; Region: YqjK; pfam13997 936157009624 Predicted membrane protein [Function unknown]; Region: COG2259 936157009625 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 936157009626 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 936157009627 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 936157009628 putative dimer interface [polypeptide binding]; other site 936157009629 N-terminal domain interface [polypeptide binding]; other site 936157009630 putative substrate binding pocket (H-site) [chemical binding]; other site 936157009631 Predicted membrane protein [Function unknown]; Region: COG3152 936157009632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157009633 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 936157009634 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 936157009635 dimerization interface [polypeptide binding]; other site 936157009636 Pirin-related protein [General function prediction only]; Region: COG1741 936157009637 Pirin; Region: Pirin; pfam02678 936157009638 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 936157009639 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 936157009640 serine transporter; Region: stp; TIGR00814 936157009641 L-serine dehydratase TdcG; Provisional; Region: PRK15040 936157009642 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 936157009643 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 936157009644 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 936157009645 Pyruvate formate lyase 1; Region: PFL1; cd01678 936157009646 coenzyme A binding site [chemical binding]; other site 936157009647 active site 936157009648 catalytic residues [active] 936157009649 glycine loop; other site 936157009650 propionate/acetate kinase; Provisional; Region: PRK12379 936157009651 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 936157009652 threonine/serine transporter TdcC; Provisional; Region: PRK13629 936157009653 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 936157009654 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 936157009655 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 936157009656 tetramer interface [polypeptide binding]; other site 936157009657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157009658 catalytic residue [active] 936157009659 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 936157009660 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157009661 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 936157009662 putative substrate binding pocket [chemical binding]; other site 936157009663 putative dimerization interface [polypeptide binding]; other site 936157009664 Glycerate kinase family; Region: Gly_kinase; cl00841 936157009665 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 936157009666 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 936157009667 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 936157009668 galactarate dehydratase; Region: galactar-dH20; TIGR03248 936157009669 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 936157009670 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 936157009671 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 936157009672 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 936157009673 intersubunit interface [polypeptide binding]; other site 936157009674 active site 936157009675 zinc binding site [ion binding]; other site 936157009676 Na+ binding site [ion binding]; other site 936157009677 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 936157009678 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936157009679 active site 936157009680 phosphorylation site [posttranslational modification] 936157009681 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 936157009682 active site 936157009683 P-loop; other site 936157009684 phosphorylation site [posttranslational modification] 936157009685 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 936157009686 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 936157009687 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 936157009688 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 936157009689 putative NAD(P) binding site [chemical binding]; other site 936157009690 catalytic Zn binding site [ion binding]; other site 936157009691 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936157009692 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 936157009693 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157009694 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 936157009695 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 936157009696 putative SAM binding site [chemical binding]; other site 936157009697 putative homodimer interface [polypeptide binding]; other site 936157009698 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 936157009699 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 936157009700 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 936157009701 putative ligand binding site [chemical binding]; other site 936157009702 TIGR00252 family protein; Region: TIGR00252 936157009703 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 936157009704 dimer interface [polypeptide binding]; other site 936157009705 active site 936157009706 outer membrane lipoprotein; Provisional; Region: PRK11023 936157009707 BON domain; Region: BON; pfam04972 936157009708 BON domain; Region: BON; pfam04972 936157009709 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 936157009710 NADH(P)-binding; Region: NAD_binding_10; pfam13460 936157009711 NAD binding site [chemical binding]; other site 936157009712 active site 936157009713 intracellular protease, PfpI family; Region: PfpI; TIGR01382 936157009714 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 936157009715 proposed catalytic triad [active] 936157009716 conserved cys residue [active] 936157009717 hypothetical protein; Provisional; Region: PRK03467 936157009718 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 936157009719 GIY-YIG motif/motif A; other site 936157009720 putative active site [active] 936157009721 putative metal binding site [ion binding]; other site 936157009722 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 936157009723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157009724 Coenzyme A binding pocket [chemical binding]; other site 936157009725 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 936157009726 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 936157009727 Peptidase family U32; Region: Peptidase_U32; pfam01136 936157009728 putative protease; Provisional; Region: PRK15447 936157009729 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 936157009730 hypothetical protein; Provisional; Region: PRK10508 936157009731 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 936157009732 tryptophan permease; Provisional; Region: PRK10483 936157009733 aromatic amino acid transport protein; Region: araaP; TIGR00837 936157009734 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 936157009735 DEAD-like helicases superfamily; Region: DEXDc; smart00487 936157009736 ATP binding site [chemical binding]; other site 936157009737 Mg++ binding site [ion binding]; other site 936157009738 motif III; other site 936157009739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157009740 nucleotide binding region [chemical binding]; other site 936157009741 ATP-binding site [chemical binding]; other site 936157009742 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 936157009743 putative RNA binding site [nucleotide binding]; other site 936157009744 lipoprotein NlpI; Provisional; Region: PRK11189 936157009745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936157009746 binding surface 936157009747 TPR motif; other site 936157009748 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 936157009749 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 936157009750 RNase E interface [polypeptide binding]; other site 936157009751 trimer interface [polypeptide binding]; other site 936157009752 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 936157009753 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 936157009754 RNase E interface [polypeptide binding]; other site 936157009755 trimer interface [polypeptide binding]; other site 936157009756 active site 936157009757 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 936157009758 putative nucleic acid binding region [nucleotide binding]; other site 936157009759 G-X-X-G motif; other site 936157009760 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 936157009761 RNA binding site [nucleotide binding]; other site 936157009762 domain interface; other site 936157009763 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 936157009764 16S/18S rRNA binding site [nucleotide binding]; other site 936157009765 S13e-L30e interaction site [polypeptide binding]; other site 936157009766 25S rRNA binding site [nucleotide binding]; other site 936157009767 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 936157009768 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 936157009769 RNA binding site [nucleotide binding]; other site 936157009770 active site 936157009771 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 936157009772 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 936157009773 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 936157009774 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 936157009775 translation initiation factor IF-2; Region: IF-2; TIGR00487 936157009776 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 936157009777 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 936157009778 G1 box; other site 936157009779 putative GEF interaction site [polypeptide binding]; other site 936157009780 GTP/Mg2+ binding site [chemical binding]; other site 936157009781 Switch I region; other site 936157009782 G2 box; other site 936157009783 G3 box; other site 936157009784 Switch II region; other site 936157009785 G4 box; other site 936157009786 G5 box; other site 936157009787 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 936157009788 Translation-initiation factor 2; Region: IF-2; pfam11987 936157009789 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 936157009790 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 936157009791 NusA N-terminal domain; Region: NusA_N; pfam08529 936157009792 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 936157009793 RNA binding site [nucleotide binding]; other site 936157009794 homodimer interface [polypeptide binding]; other site 936157009795 NusA-like KH domain; Region: KH_5; pfam13184 936157009796 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 936157009797 G-X-X-G motif; other site 936157009798 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 936157009799 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 936157009800 ribosome maturation protein RimP; Reviewed; Region: PRK00092 936157009801 Sm and related proteins; Region: Sm_like; cl00259 936157009802 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 936157009803 putative oligomer interface [polypeptide binding]; other site 936157009804 putative RNA binding site [nucleotide binding]; other site 936157009805 argininosuccinate synthase; Validated; Region: PRK05370 936157009806 argininosuccinate synthase; Provisional; Region: PRK13820 936157009807 Preprotein translocase SecG subunit; Region: SecG; pfam03840 936157009808 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 936157009809 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 936157009810 active site 936157009811 substrate binding site [chemical binding]; other site 936157009812 metal binding site [ion binding]; metal-binding site 936157009813 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 936157009814 dihydropteroate synthase; Region: DHPS; TIGR01496 936157009815 substrate binding pocket [chemical binding]; other site 936157009816 dimer interface [polypeptide binding]; other site 936157009817 inhibitor binding site; inhibition site 936157009818 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 936157009819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157009820 Walker A motif; other site 936157009821 ATP binding site [chemical binding]; other site 936157009822 Walker B motif; other site 936157009823 arginine finger; other site 936157009824 Peptidase family M41; Region: Peptidase_M41; pfam01434 936157009825 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 936157009826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157009827 S-adenosylmethionine binding site [chemical binding]; other site 936157009828 RNA-binding protein YhbY; Provisional; Region: PRK10343 936157009829 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 936157009830 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 936157009831 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 936157009832 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 936157009833 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 936157009834 GTPase CgtA; Reviewed; Region: obgE; PRK12298 936157009835 GTP1/OBG; Region: GTP1_OBG; pfam01018 936157009836 Obg GTPase; Region: Obg; cd01898 936157009837 G1 box; other site 936157009838 GTP/Mg2+ binding site [chemical binding]; other site 936157009839 Switch I region; other site 936157009840 G2 box; other site 936157009841 G3 box; other site 936157009842 Switch II region; other site 936157009843 G4 box; other site 936157009844 G5 box; other site 936157009845 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936157009846 EamA-like transporter family; Region: EamA; pfam00892 936157009847 EamA-like transporter family; Region: EamA; pfam00892 936157009848 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 936157009849 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 936157009850 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 936157009851 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 936157009852 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 936157009853 substrate binding pocket [chemical binding]; other site 936157009854 chain length determination region; other site 936157009855 substrate-Mg2+ binding site; other site 936157009856 catalytic residues [active] 936157009857 aspartate-rich region 1; other site 936157009858 active site lid residues [active] 936157009859 aspartate-rich region 2; other site 936157009860 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 936157009861 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 936157009862 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 936157009863 hinge; other site 936157009864 active site 936157009865 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 936157009866 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 936157009867 anti sigma factor interaction site; other site 936157009868 regulatory phosphorylation site [posttranslational modification]; other site 936157009869 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 936157009870 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 936157009871 mce related protein; Region: MCE; pfam02470 936157009872 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 936157009873 conserved hypothetical integral membrane protein; Region: TIGR00056 936157009874 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 936157009875 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 936157009876 Walker A/P-loop; other site 936157009877 ATP binding site [chemical binding]; other site 936157009878 Q-loop/lid; other site 936157009879 ABC transporter signature motif; other site 936157009880 Walker B; other site 936157009881 D-loop; other site 936157009882 H-loop/switch region; other site 936157009883 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 936157009884 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 936157009885 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 936157009886 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 936157009887 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 936157009888 putative active site [active] 936157009889 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 936157009890 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 936157009891 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 936157009892 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 936157009893 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 936157009894 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 936157009895 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 936157009896 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 936157009897 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 936157009898 Walker A/P-loop; other site 936157009899 ATP binding site [chemical binding]; other site 936157009900 Q-loop/lid; other site 936157009901 ABC transporter signature motif; other site 936157009902 Walker B; other site 936157009903 D-loop; other site 936157009904 H-loop/switch region; other site 936157009905 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 936157009906 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 936157009907 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 936157009908 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 936157009909 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 936157009910 30S subunit binding site; other site 936157009911 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936157009912 active site 936157009913 phosphorylation site [posttranslational modification] 936157009914 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 936157009915 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 936157009916 dimerization domain swap beta strand [polypeptide binding]; other site 936157009917 regulatory protein interface [polypeptide binding]; other site 936157009918 active site 936157009919 regulatory phosphorylation site [posttranslational modification]; other site 936157009920 hypothetical protein; Provisional; Region: PRK10345 936157009921 Transglycosylase; Region: Transgly; cl17702 936157009922 Transglycosylase; Region: Transgly; cl17702 936157009923 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 936157009924 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 936157009925 conserved cys residue [active] 936157009926 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 936157009927 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936157009928 putative active site [active] 936157009929 heme pocket [chemical binding]; other site 936157009930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157009931 dimer interface [polypeptide binding]; other site 936157009932 phosphorylation site [posttranslational modification] 936157009933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157009934 ATP binding site [chemical binding]; other site 936157009935 Mg2+ binding site [ion binding]; other site 936157009936 G-X-G motif; other site 936157009937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157009938 active site 936157009939 phosphorylation site [posttranslational modification] 936157009940 intermolecular recognition site; other site 936157009941 dimerization interface [polypeptide binding]; other site 936157009942 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 936157009943 putative binding surface; other site 936157009944 active site 936157009945 radical SAM protein, TIGR01212 family; Region: TIGR01212 936157009946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157009947 FeS/SAM binding site; other site 936157009948 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 936157009949 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 936157009950 active site 936157009951 dimer interface [polypeptide binding]; other site 936157009952 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 936157009953 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 936157009954 active site 936157009955 FMN binding site [chemical binding]; other site 936157009956 substrate binding site [chemical binding]; other site 936157009957 3Fe-4S cluster binding site [ion binding]; other site 936157009958 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 936157009959 domain interface; other site 936157009960 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 936157009961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936157009962 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936157009963 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 936157009964 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 936157009965 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 936157009966 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 936157009967 Na binding site [ion binding]; other site 936157009968 putative substrate binding site [chemical binding]; other site 936157009969 cytosine deaminase; Provisional; Region: PRK09230 936157009970 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 936157009971 active site 936157009972 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 936157009973 N-acetylmannosamine kinase; Provisional; Region: PRK05082 936157009974 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936157009975 nucleotide binding site [chemical binding]; other site 936157009976 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 936157009977 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 936157009978 putative active site cavity [active] 936157009979 putative sialic acid transporter; Provisional; Region: PRK03893 936157009980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157009981 putative substrate translocation pore; other site 936157009982 N-acetylneuraminate lyase; Provisional; Region: PRK04147 936157009983 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 936157009984 inhibitor site; inhibition site 936157009985 active site 936157009986 dimer interface [polypeptide binding]; other site 936157009987 catalytic residue [active] 936157009988 transcriptional regulator NanR; Provisional; Region: PRK03837 936157009989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157009990 DNA-binding site [nucleotide binding]; DNA binding site 936157009991 FCD domain; Region: FCD; pfam07729 936157009992 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 936157009993 stringent starvation protein A; Provisional; Region: sspA; PRK09481 936157009994 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 936157009995 C-terminal domain interface [polypeptide binding]; other site 936157009996 putative GSH binding site (G-site) [chemical binding]; other site 936157009997 dimer interface [polypeptide binding]; other site 936157009998 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 936157009999 dimer interface [polypeptide binding]; other site 936157010000 N-terminal domain interface [polypeptide binding]; other site 936157010001 Family of unknown function (DUF695); Region: DUF695; pfam05117 936157010002 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 936157010003 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 936157010004 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 936157010005 23S rRNA interface [nucleotide binding]; other site 936157010006 L3 interface [polypeptide binding]; other site 936157010007 Predicted ATPase [General function prediction only]; Region: COG1485 936157010008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 936157010009 hypothetical protein; Provisional; Region: PRK11677 936157010010 serine endoprotease; Provisional; Region: PRK10139 936157010011 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 936157010012 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 936157010013 protein binding site [polypeptide binding]; other site 936157010014 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 936157010015 serine endoprotease; Provisional; Region: PRK10898 936157010016 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 936157010017 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 936157010018 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 936157010019 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 936157010020 Sodium ion-translocating decarboxylase 936157010021 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 936157010022 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 936157010023 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 936157010024 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 936157010025 transmembrane helices; other site 936157010026 Transcriptional regulators [Transcription]; Region: GntR; COG1802 936157010027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157010028 DNA-binding site [nucleotide binding]; DNA binding site 936157010029 FCD domain; Region: FCD; pfam07729 936157010030 Transcriptional regulators [Transcription]; Region: GntR; COG1802 936157010031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157010032 DNA-binding site [nucleotide binding]; DNA binding site 936157010033 malate dehydrogenase; Provisional; Region: PRK05086 936157010034 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 936157010035 NAD binding site [chemical binding]; other site 936157010036 dimerization interface [polypeptide binding]; other site 936157010037 Substrate binding site [chemical binding]; other site 936157010038 arginine repressor; Provisional; Region: PRK05066 936157010039 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 936157010040 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 936157010041 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 936157010042 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 936157010043 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 936157010044 RNAase interaction site [polypeptide binding]; other site 936157010045 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 936157010046 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 936157010047 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 936157010048 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936157010049 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157010050 efflux system membrane protein; Provisional; Region: PRK11594 936157010051 transcriptional regulator; Provisional; Region: PRK10632 936157010052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157010053 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 936157010054 putative effector binding pocket; other site 936157010055 dimerization interface [polypeptide binding]; other site 936157010056 protease TldD; Provisional; Region: tldD; PRK10735 936157010057 hypothetical protein; Provisional; Region: PRK10899 936157010058 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 936157010059 ribonuclease G; Provisional; Region: PRK11712 936157010060 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 936157010061 homodimer interface [polypeptide binding]; other site 936157010062 oligonucleotide binding site [chemical binding]; other site 936157010063 Maf-like protein; Region: Maf; pfam02545 936157010064 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 936157010065 active site 936157010066 dimer interface [polypeptide binding]; other site 936157010067 rod shape-determining protein MreD; Provisional; Region: PRK11060 936157010068 rod shape-determining protein MreC; Region: mreC; TIGR00219 936157010069 rod shape-determining protein MreC; Region: MreC; pfam04085 936157010070 rod shape-determining protein MreB; Provisional; Region: PRK13927 936157010071 MreB and similar proteins; Region: MreB_like; cd10225 936157010072 nucleotide binding site [chemical binding]; other site 936157010073 Mg binding site [ion binding]; other site 936157010074 putative protofilament interaction site [polypeptide binding]; other site 936157010075 RodZ interaction site [polypeptide binding]; other site 936157010076 regulatory protein CsrD; Provisional; Region: PRK11059 936157010077 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936157010078 metal binding site [ion binding]; metal-binding site 936157010079 active site 936157010080 I-site; other site 936157010081 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157010082 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 936157010083 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 936157010084 NADP binding site [chemical binding]; other site 936157010085 dimer interface [polypeptide binding]; other site 936157010086 TMAO/DMSO reductase; Reviewed; Region: PRK05363 936157010087 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 936157010088 Moco binding site; other site 936157010089 metal coordination site [ion binding]; other site 936157010090 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 936157010091 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 936157010092 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 936157010093 carboxyltransferase (CT) interaction site; other site 936157010094 biotinylation site [posttranslational modification]; other site 936157010095 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 936157010096 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 936157010097 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 936157010098 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 936157010099 hypothetical protein; Provisional; Region: PRK10633 936157010100 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 936157010101 Na binding site [ion binding]; other site 936157010102 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 936157010103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 936157010104 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 936157010105 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 936157010106 FMN binding site [chemical binding]; other site 936157010107 active site 936157010108 catalytic residues [active] 936157010109 substrate binding site [chemical binding]; other site 936157010110 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 936157010111 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 936157010112 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 936157010113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157010114 DNA methylase; Region: N6_N4_Mtase; pfam01555 936157010115 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 936157010116 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 936157010117 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 936157010118 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 936157010119 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936157010120 metal binding site [ion binding]; metal-binding site 936157010121 active site 936157010122 I-site; other site 936157010123 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157010124 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 936157010125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157010126 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 936157010127 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 936157010128 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936157010129 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157010130 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 936157010131 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 936157010132 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 936157010133 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 936157010134 trimer interface [polypeptide binding]; other site 936157010135 putative metal binding site [ion binding]; other site 936157010136 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 936157010137 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 936157010138 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 936157010139 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 936157010140 shikimate binding site; other site 936157010141 NAD(P) binding site [chemical binding]; other site 936157010142 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 936157010143 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 936157010144 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 936157010145 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 936157010146 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 936157010147 hypothetical protein; Validated; Region: PRK03430 936157010148 hypothetical protein; Provisional; Region: PRK10736 936157010149 DNA protecting protein DprA; Region: dprA; TIGR00732 936157010150 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 936157010151 active site 936157010152 catalytic residues [active] 936157010153 metal binding site [ion binding]; metal-binding site 936157010154 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 936157010155 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 936157010156 putative active site [active] 936157010157 substrate binding site [chemical binding]; other site 936157010158 putative cosubstrate binding site; other site 936157010159 catalytic site [active] 936157010160 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 936157010161 substrate binding site [chemical binding]; other site 936157010162 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 936157010163 putative RNA binding site [nucleotide binding]; other site 936157010164 16S rRNA methyltransferase B; Provisional; Region: PRK10901 936157010165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157010166 S-adenosylmethionine binding site [chemical binding]; other site 936157010167 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 936157010168 TrkA-N domain; Region: TrkA_N; pfam02254 936157010169 TrkA-C domain; Region: TrkA_C; pfam02080 936157010170 TrkA-N domain; Region: TrkA_N; pfam02254 936157010171 TrkA-C domain; Region: TrkA_C; pfam02080 936157010172 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 936157010173 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 936157010174 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 936157010175 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 936157010176 DNA binding residues [nucleotide binding] 936157010177 dimer interface [polypeptide binding]; other site 936157010178 metal binding site [ion binding]; metal-binding site 936157010179 hypothetical protein; Provisional; Region: PRK10203 936157010180 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 936157010181 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 936157010182 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 936157010183 alphaNTD homodimer interface [polypeptide binding]; other site 936157010184 alphaNTD - beta interaction site [polypeptide binding]; other site 936157010185 alphaNTD - beta' interaction site [polypeptide binding]; other site 936157010186 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 936157010187 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 936157010188 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 936157010189 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936157010190 RNA binding surface [nucleotide binding]; other site 936157010191 30S ribosomal protein S11; Validated; Region: PRK05309 936157010192 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 936157010193 30S ribosomal protein S13; Region: bact_S13; TIGR03631 936157010194 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 936157010195 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 936157010196 SecY translocase; Region: SecY; pfam00344 936157010197 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 936157010198 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 936157010199 23S rRNA binding site [nucleotide binding]; other site 936157010200 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 936157010201 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 936157010202 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 936157010203 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 936157010204 23S rRNA interface [nucleotide binding]; other site 936157010205 5S rRNA interface [nucleotide binding]; other site 936157010206 L27 interface [polypeptide binding]; other site 936157010207 L5 interface [polypeptide binding]; other site 936157010208 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 936157010209 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 936157010210 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 936157010211 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 936157010212 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 936157010213 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 936157010214 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 936157010215 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 936157010216 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 936157010217 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 936157010218 RNA binding site [nucleotide binding]; other site 936157010219 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 936157010220 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 936157010221 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 936157010222 23S rRNA interface [nucleotide binding]; other site 936157010223 putative translocon interaction site; other site 936157010224 signal recognition particle (SRP54) interaction site; other site 936157010225 L23 interface [polypeptide binding]; other site 936157010226 trigger factor interaction site; other site 936157010227 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 936157010228 23S rRNA interface [nucleotide binding]; other site 936157010229 5S rRNA interface [nucleotide binding]; other site 936157010230 putative antibiotic binding site [chemical binding]; other site 936157010231 L25 interface [polypeptide binding]; other site 936157010232 L27 interface [polypeptide binding]; other site 936157010233 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 936157010234 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 936157010235 G-X-X-G motif; other site 936157010236 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 936157010237 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 936157010238 protein-rRNA interface [nucleotide binding]; other site 936157010239 putative translocon binding site; other site 936157010240 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 936157010241 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 936157010242 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 936157010243 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 936157010244 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 936157010245 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 936157010246 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 936157010247 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 936157010248 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 936157010249 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 936157010250 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 936157010251 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 936157010252 heme binding site [chemical binding]; other site 936157010253 ferroxidase pore; other site 936157010254 ferroxidase diiron center [ion binding]; other site 936157010255 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 936157010256 Autotransporter beta-domain; Region: Autotransporter; pfam03797 936157010257 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 936157010258 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 936157010259 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 936157010260 active site 936157010261 HIGH motif; other site 936157010262 dimer interface [polypeptide binding]; other site 936157010263 KMSKS motif; other site 936157010264 phosphoglycolate phosphatase; Provisional; Region: PRK13222 936157010265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157010266 motif II; other site 936157010267 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 936157010268 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 936157010269 substrate binding site [chemical binding]; other site 936157010270 hexamer interface [polypeptide binding]; other site 936157010271 metal binding site [ion binding]; metal-binding site 936157010272 DNA adenine methylase; Provisional; Region: PRK10904 936157010273 cell division protein DamX; Validated; Region: PRK10905 936157010274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 936157010275 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 936157010276 active site 936157010277 dimer interface [polypeptide binding]; other site 936157010278 metal binding site [ion binding]; metal-binding site 936157010279 shikimate kinase; Reviewed; Region: aroK; PRK00131 936157010280 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 936157010281 ADP binding site [chemical binding]; other site 936157010282 magnesium binding site [ion binding]; other site 936157010283 putative shikimate binding site; other site 936157010284 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 936157010285 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 936157010286 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 936157010287 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 936157010288 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 936157010289 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 936157010290 Transglycosylase; Region: Transgly; pfam00912 936157010291 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 936157010292 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 936157010293 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 936157010294 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 936157010295 ADP-ribose binding site [chemical binding]; other site 936157010296 dimer interface [polypeptide binding]; other site 936157010297 active site 936157010298 nudix motif; other site 936157010299 metal binding site [ion binding]; metal-binding site 936157010300 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 936157010301 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 936157010302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157010303 motif II; other site 936157010304 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936157010305 RNA binding surface [nucleotide binding]; other site 936157010306 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 936157010307 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 936157010308 dimerization interface [polypeptide binding]; other site 936157010309 domain crossover interface; other site 936157010310 redox-dependent activation switch; other site 936157010311 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 936157010312 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 936157010313 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 936157010314 active site 936157010315 substrate-binding site [chemical binding]; other site 936157010316 metal-binding site [ion binding] 936157010317 ATP binding site [chemical binding]; other site 936157010318 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 936157010319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157010320 dimerization interface [polypeptide binding]; other site 936157010321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157010322 dimer interface [polypeptide binding]; other site 936157010323 phosphorylation site [posttranslational modification] 936157010324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157010325 ATP binding site [chemical binding]; other site 936157010326 G-X-G motif; other site 936157010327 osmolarity response regulator; Provisional; Region: ompR; PRK09468 936157010328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157010329 active site 936157010330 phosphorylation site [posttranslational modification] 936157010331 intermolecular recognition site; other site 936157010332 dimerization interface [polypeptide binding]; other site 936157010333 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157010334 DNA binding site [nucleotide binding] 936157010335 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 936157010336 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 936157010337 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 936157010338 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 936157010339 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 936157010340 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 936157010341 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 936157010342 RNA binding site [nucleotide binding]; other site 936157010343 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 936157010344 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 936157010345 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 936157010346 G1 box; other site 936157010347 GTP/Mg2+ binding site [chemical binding]; other site 936157010348 Switch I region; other site 936157010349 G2 box; other site 936157010350 G3 box; other site 936157010351 Switch II region; other site 936157010352 G4 box; other site 936157010353 G5 box; other site 936157010354 Nucleoside recognition; Region: Gate; pfam07670 936157010355 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 936157010356 Nucleoside recognition; Region: Gate; pfam07670 936157010357 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 936157010358 hypothetical protein; Provisional; Region: PRK09956 936157010359 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 936157010360 carboxylesterase BioH; Provisional; Region: PRK10349 936157010361 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 936157010362 DNA utilization protein GntX; Provisional; Region: PRK11595 936157010363 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936157010364 active site 936157010365 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 936157010366 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 936157010367 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 936157010368 high-affinity gluconate transporter; Provisional; Region: PRK14984 936157010369 gluconate transporter; Region: gntP; TIGR00791 936157010370 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 936157010371 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 936157010372 maltodextrin phosphorylase; Provisional; Region: PRK14985 936157010373 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 936157010374 homodimer interface [polypeptide binding]; other site 936157010375 active site pocket [active] 936157010376 transcriptional regulator MalT; Provisional; Region: PRK04841 936157010377 AAA ATPase domain; Region: AAA_16; pfam13191 936157010378 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157010379 DNA binding residues [nucleotide binding] 936157010380 dimerization interface [polypeptide binding]; other site 936157010381 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 936157010382 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 936157010383 putative active site [active] 936157010384 adenylation catalytic residue [active] 936157010385 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 936157010386 hypothetical protein; Reviewed; Region: PRK09588 936157010387 TROVE domain; Region: TROVE; pfam05731 936157010388 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 936157010389 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 936157010390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157010391 Walker A motif; other site 936157010392 ATP binding site [chemical binding]; other site 936157010393 Walker B motif; other site 936157010394 arginine finger; other site 936157010395 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 936157010396 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 936157010397 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157010398 intramembrane serine protease GlpG; Provisional; Region: PRK10907 936157010399 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 936157010400 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 936157010401 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 936157010402 active site residue [active] 936157010403 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 936157010404 hypothetical protein; Provisional; Region: PRK09781 936157010405 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 936157010406 glycogen phosphorylase; Provisional; Region: PRK14986 936157010407 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 936157010408 homodimer interface [polypeptide binding]; other site 936157010409 active site pocket [active] 936157010410 glycogen synthase; Provisional; Region: glgA; PRK00654 936157010411 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 936157010412 ADP-binding pocket [chemical binding]; other site 936157010413 homodimer interface [polypeptide binding]; other site 936157010414 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 936157010415 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 936157010416 ligand binding site; other site 936157010417 oligomer interface; other site 936157010418 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 936157010419 dimer interface [polypeptide binding]; other site 936157010420 N-terminal domain interface [polypeptide binding]; other site 936157010421 sulfate 1 binding site; other site 936157010422 glycogen debranching enzyme; Provisional; Region: PRK03705 936157010423 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 936157010424 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 936157010425 active site 936157010426 catalytic site [active] 936157010427 glycogen branching enzyme; Provisional; Region: PRK05402 936157010428 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 936157010429 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 936157010430 active site 936157010431 catalytic site [active] 936157010432 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 936157010433 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 936157010434 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 936157010435 low affinity gluconate transporter; Provisional; Region: PRK10472 936157010436 gluconate transporter; Region: gntP; TIGR00791 936157010437 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 936157010438 ATP-binding site [chemical binding]; other site 936157010439 Gluconate-6-phosphate binding site [chemical binding]; other site 936157010440 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 936157010441 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157010442 DNA binding site [nucleotide binding] 936157010443 domain linker motif; other site 936157010444 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 936157010445 putative ligand binding site [chemical binding]; other site 936157010446 putative dimerization interface [polypeptide binding]; other site 936157010447 Pirin-related protein [General function prediction only]; Region: COG1741 936157010448 Pirin; Region: Pirin; pfam02678 936157010449 putative oxidoreductase; Provisional; Region: PRK10206 936157010450 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936157010451 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936157010452 putative acetyltransferase YhhY; Provisional; Region: PRK10140 936157010453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157010454 Coenzyme A binding pocket [chemical binding]; other site 936157010455 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936157010456 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 936157010457 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936157010458 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 936157010459 substrate binding site [chemical binding]; other site 936157010460 dimer interface [polypeptide binding]; other site 936157010461 ATP binding site [chemical binding]; other site 936157010462 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 936157010463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 936157010464 Protein of unknown function, DUF606; Region: DUF606; pfam04657 936157010465 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 936157010466 active site 936157010467 substrate binding pocket [chemical binding]; other site 936157010468 homodimer interaction site [polypeptide binding]; other site 936157010469 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 936157010470 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 936157010471 hypothetical protein; Provisional; Region: PRK10350 936157010472 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 936157010473 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 936157010474 putative active site [active] 936157010475 catalytic site [active] 936157010476 putative metal binding site [ion binding]; other site 936157010477 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 936157010478 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 936157010479 Walker A/P-loop; other site 936157010480 ATP binding site [chemical binding]; other site 936157010481 Q-loop/lid; other site 936157010482 ABC transporter signature motif; other site 936157010483 Walker B; other site 936157010484 D-loop; other site 936157010485 H-loop/switch region; other site 936157010486 TOBE domain; Region: TOBE_2; pfam08402 936157010487 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 936157010488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157010489 dimer interface [polypeptide binding]; other site 936157010490 conserved gate region; other site 936157010491 ABC-ATPase subunit interface; other site 936157010492 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 936157010493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157010494 dimer interface [polypeptide binding]; other site 936157010495 conserved gate region; other site 936157010496 putative PBP binding loops; other site 936157010497 ABC-ATPase subunit interface; other site 936157010498 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 936157010499 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 936157010500 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 936157010501 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 936157010502 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 936157010503 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 936157010504 Walker A/P-loop; other site 936157010505 ATP binding site [chemical binding]; other site 936157010506 Q-loop/lid; other site 936157010507 ABC transporter signature motif; other site 936157010508 Walker B; other site 936157010509 D-loop; other site 936157010510 H-loop/switch region; other site 936157010511 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 936157010512 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 936157010513 Walker A/P-loop; other site 936157010514 ATP binding site [chemical binding]; other site 936157010515 Q-loop/lid; other site 936157010516 ABC transporter signature motif; other site 936157010517 Walker B; other site 936157010518 D-loop; other site 936157010519 H-loop/switch region; other site 936157010520 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 936157010521 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 936157010522 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 936157010523 TM-ABC transporter signature motif; other site 936157010524 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 936157010525 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 936157010526 TM-ABC transporter signature motif; other site 936157010527 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 936157010528 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 936157010529 dimerization interface [polypeptide binding]; other site 936157010530 ligand binding site [chemical binding]; other site 936157010531 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 936157010532 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 936157010533 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 936157010534 dimerization interface [polypeptide binding]; other site 936157010535 ligand binding site [chemical binding]; other site 936157010536 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 936157010537 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 936157010538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 936157010539 DNA binding residues [nucleotide binding] 936157010540 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 936157010541 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 936157010542 cell division protein FtsE; Provisional; Region: PRK10908 936157010543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157010544 Walker A/P-loop; other site 936157010545 ATP binding site [chemical binding]; other site 936157010546 Q-loop/lid; other site 936157010547 ABC transporter signature motif; other site 936157010548 Walker B; other site 936157010549 D-loop; other site 936157010550 H-loop/switch region; other site 936157010551 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 936157010552 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 936157010553 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 936157010554 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 936157010555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157010556 S-adenosylmethionine binding site [chemical binding]; other site 936157010557 hypothetical protein; Provisional; Region: PRK10910 936157010558 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 936157010559 Predicted membrane protein [Function unknown]; Region: COG3714 936157010560 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 936157010561 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 936157010562 metal-binding site [ion binding] 936157010563 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936157010564 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 936157010565 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 936157010566 dimer interface [polypeptide binding]; other site 936157010567 ligand binding site [chemical binding]; other site 936157010568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157010569 dimerization interface [polypeptide binding]; other site 936157010570 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936157010571 dimer interface [polypeptide binding]; other site 936157010572 putative CheW interface [polypeptide binding]; other site 936157010573 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 936157010574 CPxP motif; other site 936157010575 hypothetical protein; Provisional; Region: PRK11212 936157010576 hypothetical protein; Provisional; Region: PRK11615 936157010577 major facilitator superfamily transporter; Provisional; Region: PRK05122 936157010578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157010579 putative substrate translocation pore; other site 936157010580 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 936157010581 Domain of unknown function DUF20; Region: UPF0118; pfam01594 936157010582 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 936157010583 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 936157010584 nickel responsive regulator; Provisional; Region: PRK02967 936157010585 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 936157010586 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 936157010587 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 936157010588 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936157010589 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 936157010590 Walker A/P-loop; other site 936157010591 ATP binding site [chemical binding]; other site 936157010592 Q-loop/lid; other site 936157010593 ABC transporter signature motif; other site 936157010594 Walker B; other site 936157010595 D-loop; other site 936157010596 H-loop/switch region; other site 936157010597 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 936157010598 Walker A/P-loop; other site 936157010599 ATP binding site [chemical binding]; other site 936157010600 Q-loop/lid; other site 936157010601 ABC transporter signature motif; other site 936157010602 Walker B; other site 936157010603 D-loop; other site 936157010604 H-loop/switch region; other site 936157010605 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 936157010606 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 936157010607 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 936157010608 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936157010609 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157010610 Predicted flavoproteins [General function prediction only]; Region: COG2081 936157010611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936157010612 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 936157010613 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 936157010614 universal stress protein UspB; Provisional; Region: PRK04960 936157010615 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 936157010616 Ligand Binding Site [chemical binding]; other site 936157010617 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 936157010618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157010619 putative substrate translocation pore; other site 936157010620 POT family; Region: PTR2; pfam00854 936157010621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157010622 S-adenosylmethionine binding site [chemical binding]; other site 936157010623 oligopeptidase A; Provisional; Region: PRK10911 936157010624 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 936157010625 active site 936157010626 Zn binding site [ion binding]; other site 936157010627 hypothetical protein; Provisional; Region: PRK10215 936157010628 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 936157010629 glutathione reductase; Validated; Region: PRK06116 936157010630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 936157010631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936157010632 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 936157010633 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 936157010634 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 936157010635 active site 936157010636 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 936157010637 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 936157010638 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 936157010639 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936157010640 substrate binding site [chemical binding]; other site 936157010641 ATP binding site [chemical binding]; other site 936157010642 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 936157010643 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 936157010644 putative active site [active] 936157010645 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 936157010646 dimer interface [polypeptide binding]; other site 936157010647 active site 936157010648 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 936157010649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157010650 DNA-binding site [nucleotide binding]; DNA binding site 936157010651 UTRA domain; Region: UTRA; pfam07702 936157010652 trehalase; Provisional; Region: treF; PRK13270 936157010653 Trehalase; Region: Trehalase; pfam01204 936157010654 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 936157010655 catalytic residue [active] 936157010656 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936157010657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 936157010658 active site 936157010659 phosphorylation site [posttranslational modification] 936157010660 dimerization interface [polypeptide binding]; other site 936157010661 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157010662 DNA binding residues [nucleotide binding] 936157010663 dimerization interface [polypeptide binding]; other site 936157010664 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157010665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157010666 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 936157010667 putative effector binding pocket; other site 936157010668 putative dimerization interface [polypeptide binding]; other site 936157010669 inner membrane protein YhjD; Region: TIGR00766 936157010670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157010671 metabolite-proton symporter; Region: 2A0106; TIGR00883 936157010672 putative substrate translocation pore; other site 936157010673 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 936157010674 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 936157010675 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157010676 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936157010677 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 936157010678 substrate binding site [chemical binding]; other site 936157010679 ATP binding site [chemical binding]; other site 936157010680 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 936157010681 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 936157010682 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 936157010683 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 936157010684 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 936157010685 putative diguanylate cyclase; Provisional; Region: PRK13561 936157010686 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936157010687 metal binding site [ion binding]; metal-binding site 936157010688 active site 936157010689 I-site; other site 936157010690 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157010691 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 936157010692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936157010693 TPR motif; other site 936157010694 binding surface 936157010695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936157010696 TPR motif; other site 936157010697 binding surface 936157010698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 936157010699 binding surface 936157010700 TPR motif; other site 936157010701 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 936157010702 endo-1,4-D-glucanase; Provisional; Region: PRK11097 936157010703 cellulose synthase regulator protein; Provisional; Region: PRK11114 936157010704 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 936157010705 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 936157010706 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 936157010707 DXD motif; other site 936157010708 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 936157010709 PilZ domain; Region: PilZ; pfam07238 936157010710 cell division protein; Provisional; Region: PRK10037 936157010711 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 936157010712 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 936157010713 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 936157010714 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 936157010715 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 936157010716 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 936157010717 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 936157010718 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 936157010719 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 936157010720 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 936157010721 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 936157010722 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936157010723 Walker A/P-loop; other site 936157010724 ATP binding site [chemical binding]; other site 936157010725 Q-loop/lid; other site 936157010726 ABC transporter signature motif; other site 936157010727 Walker B; other site 936157010728 D-loop; other site 936157010729 H-loop/switch region; other site 936157010730 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 936157010731 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 936157010732 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 936157010733 Walker A/P-loop; other site 936157010734 ATP binding site [chemical binding]; other site 936157010735 Q-loop/lid; other site 936157010736 ABC transporter signature motif; other site 936157010737 Walker B; other site 936157010738 D-loop; other site 936157010739 H-loop/switch region; other site 936157010740 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 936157010741 dipeptide transporter; Provisional; Region: PRK10913 936157010742 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 936157010743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157010744 dimer interface [polypeptide binding]; other site 936157010745 conserved gate region; other site 936157010746 putative PBP binding loops; other site 936157010747 ABC-ATPase subunit interface; other site 936157010748 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 936157010749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157010750 dimer interface [polypeptide binding]; other site 936157010751 conserved gate region; other site 936157010752 putative PBP binding loops; other site 936157010753 ABC-ATPase subunit interface; other site 936157010754 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 936157010755 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 936157010756 peptide binding site [polypeptide binding]; other site 936157010757 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 936157010758 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 936157010759 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936157010760 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157010761 DNA binding site [nucleotide binding] 936157010762 domain linker motif; other site 936157010763 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 936157010764 putative dimerization interface [polypeptide binding]; other site 936157010765 putative ligand binding site [chemical binding]; other site 936157010766 phosphoethanolamine transferase; Provisional; Region: PRK11560 936157010767 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 936157010768 Sulfatase; Region: Sulfatase; pfam00884 936157010769 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 936157010770 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 936157010771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157010772 Coenzyme A binding pocket [chemical binding]; other site 936157010773 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 936157010774 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 936157010775 molybdopterin cofactor binding site [chemical binding]; other site 936157010776 substrate binding site [chemical binding]; other site 936157010777 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 936157010778 molybdopterin cofactor binding site; other site 936157010779 putative outer membrane lipoprotein; Provisional; Region: PRK10510 936157010780 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 936157010781 ligand binding site [chemical binding]; other site 936157010782 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 936157010783 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 936157010784 dimerization interface [polypeptide binding]; other site 936157010785 ligand binding site [chemical binding]; other site 936157010786 NADP binding site [chemical binding]; other site 936157010787 catalytic site [active] 936157010788 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 936157010789 Predicted transcriptional regulator [Transcription]; Region: COG2944 936157010790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157010791 salt bridge; other site 936157010792 non-specific DNA binding site [nucleotide binding]; other site 936157010793 sequence-specific DNA binding site [nucleotide binding]; other site 936157010794 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 936157010795 DNA-binding site [nucleotide binding]; DNA binding site 936157010796 RNA-binding motif; other site 936157010797 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 936157010798 DALR anticodon binding domain; Region: DALR_1; pfam05746 936157010799 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 936157010800 dimer interface [polypeptide binding]; other site 936157010801 motif 1; other site 936157010802 active site 936157010803 motif 2; other site 936157010804 motif 3; other site 936157010805 YsaB-like lipoprotein; Region: YsaB; pfam13983 936157010806 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 936157010807 Acyltransferase family; Region: Acyl_transf_3; pfam01757 936157010808 Predicted membrane protein [Function unknown]; Region: COG4682 936157010809 yiaA/B two helix domain; Region: YiaAB; cl01759 936157010810 yiaA/B two helix domain; Region: YiaAB; cl01759 936157010811 xylulokinase; Provisional; Region: PRK15027 936157010812 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 936157010813 N- and C-terminal domain interface [polypeptide binding]; other site 936157010814 active site 936157010815 MgATP binding site [chemical binding]; other site 936157010816 catalytic site [active] 936157010817 metal binding site [ion binding]; metal-binding site 936157010818 xylulose binding site [chemical binding]; other site 936157010819 homodimer interface [polypeptide binding]; other site 936157010820 xylose isomerase; Provisional; Region: PRK05474 936157010821 xylose isomerase; Region: xylose_isom_A; TIGR02630 936157010822 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 936157010823 putative dimerization interface [polypeptide binding]; other site 936157010824 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936157010825 putative ligand binding site [chemical binding]; other site 936157010826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157010827 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936157010828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157010829 hypothetical protein; Provisional; Region: PRK10356 936157010830 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 936157010831 alpha-amylase; Reviewed; Region: malS; PRK09505 936157010832 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 936157010833 active site 936157010834 catalytic site [active] 936157010835 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 936157010836 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936157010837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157010838 homodimer interface [polypeptide binding]; other site 936157010839 catalytic residue [active] 936157010840 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 936157010841 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 936157010842 Transcriptional regulator [Transcription]; Region: IclR; COG1414 936157010843 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 936157010844 Bacterial transcriptional regulator; Region: IclR; pfam01614 936157010845 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 936157010846 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 936157010847 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 936157010848 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 936157010849 DctM-like transporters; Region: DctM; pfam06808 936157010850 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 936157010851 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 936157010852 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 936157010853 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 936157010854 putative N- and C-terminal domain interface [polypeptide binding]; other site 936157010855 putative active site [active] 936157010856 MgATP binding site [chemical binding]; other site 936157010857 catalytic site [active] 936157010858 metal binding site [ion binding]; metal-binding site 936157010859 putative xylulose binding site [chemical binding]; other site 936157010860 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 936157010861 active site 936157010862 dimer interface [polypeptide binding]; other site 936157010863 magnesium binding site [ion binding]; other site 936157010864 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 936157010865 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 936157010866 AP (apurinic/apyrimidinic) site pocket; other site 936157010867 DNA interaction; other site 936157010868 Metal-binding active site; metal-binding site 936157010869 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 936157010870 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 936157010871 intersubunit interface [polypeptide binding]; other site 936157010872 active site 936157010873 Zn2+ binding site [ion binding]; other site 936157010874 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 936157010875 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 936157010876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157010877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 936157010878 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 936157010879 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 936157010880 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 936157010881 NAD(P) binding site [chemical binding]; other site 936157010882 catalytic residues [active] 936157010883 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 936157010884 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 936157010885 nucleotide binding site [chemical binding]; other site 936157010886 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 936157010887 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 936157010888 G1 box; other site 936157010889 putative GEF interaction site [polypeptide binding]; other site 936157010890 GTP/Mg2+ binding site [chemical binding]; other site 936157010891 Switch I region; other site 936157010892 G2 box; other site 936157010893 G3 box; other site 936157010894 Switch II region; other site 936157010895 G4 box; other site 936157010896 G5 box; other site 936157010897 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 936157010898 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 936157010899 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 936157010900 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 936157010901 selenocysteine synthase; Provisional; Region: PRK04311 936157010902 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 936157010903 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 936157010904 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936157010905 catalytic residue [active] 936157010906 putative glutathione S-transferase; Provisional; Region: PRK10357 936157010907 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 936157010908 putative C-terminal domain interface [polypeptide binding]; other site 936157010909 putative GSH binding site (G-site) [chemical binding]; other site 936157010910 putative dimer interface [polypeptide binding]; other site 936157010911 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 936157010912 dimer interface [polypeptide binding]; other site 936157010913 N-terminal domain interface [polypeptide binding]; other site 936157010914 putative substrate binding pocket (H-site) [chemical binding]; other site 936157010915 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 936157010916 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936157010917 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157010918 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 936157010919 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 936157010920 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 936157010921 active site 936157010922 P-loop; other site 936157010923 phosphorylation site [posttranslational modification] 936157010924 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936157010925 active site 936157010926 phosphorylation site [posttranslational modification] 936157010927 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 936157010928 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 936157010929 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 936157010930 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 936157010931 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 936157010932 hypothetical protein; Provisional; Region: PRK11020 936157010933 L-lactate permease; Provisional; Region: PRK10420 936157010934 glycolate transporter; Provisional; Region: PRK09695 936157010935 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 936157010936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157010937 DNA-binding site [nucleotide binding]; DNA binding site 936157010938 FCD domain; Region: FCD; pfam07729 936157010939 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 936157010940 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 936157010941 active site 936157010942 substrate binding site [chemical binding]; other site 936157010943 FMN binding site [chemical binding]; other site 936157010944 putative catalytic residues [active] 936157010945 putative rRNA methylase; Provisional; Region: PRK10358 936157010946 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 936157010947 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936157010948 Transcriptional regulators [Transcription]; Region: PurR; COG1609 936157010949 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157010950 DNA binding site [nucleotide binding] 936157010951 domain linker motif; other site 936157010952 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 936157010953 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 936157010954 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 936157010955 active site pocket [active] 936157010956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157010957 D-galactonate transporter; Region: 2A0114; TIGR00893 936157010958 putative substrate translocation pore; other site 936157010959 serine acetyltransferase; Provisional; Region: cysE; PRK11132 936157010960 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 936157010961 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 936157010962 trimer interface [polypeptide binding]; other site 936157010963 active site 936157010964 substrate binding site [chemical binding]; other site 936157010965 CoA binding site [chemical binding]; other site 936157010966 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 936157010967 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 936157010968 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 936157010969 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 936157010970 SecA binding site; other site 936157010971 Preprotein binding site; other site 936157010972 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 936157010973 GSH binding site [chemical binding]; other site 936157010974 catalytic residues [active] 936157010975 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 936157010976 active site residue [active] 936157010977 phosphoglyceromutase; Provisional; Region: PRK05434 936157010978 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 936157010979 AmiB activator; Provisional; Region: PRK11637 936157010980 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 936157010981 Peptidase family M23; Region: Peptidase_M23; pfam01551 936157010982 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 936157010983 NodB motif; other site 936157010984 putative active site [active] 936157010985 putative catalytic site [active] 936157010986 Zn binding site [ion binding]; other site 936157010987 putative glycosyl transferase; Provisional; Region: PRK10073 936157010988 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 936157010989 active site 936157010990 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 936157010991 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 936157010992 NAD(P) binding site [chemical binding]; other site 936157010993 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 936157010994 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 936157010995 substrate-cofactor binding pocket; other site 936157010996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157010997 catalytic residue [active] 936157010998 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 936157010999 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 936157011000 NADP binding site [chemical binding]; other site 936157011001 homopentamer interface [polypeptide binding]; other site 936157011002 substrate binding site [chemical binding]; other site 936157011003 active site 936157011004 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 936157011005 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 936157011006 putative active site [active] 936157011007 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 936157011008 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 936157011009 putative active site [active] 936157011010 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 936157011011 O-antigen ligase RfaL; Provisional; Region: PRK15487 936157011012 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 936157011013 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 936157011014 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 936157011015 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 936157011016 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 936157011017 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 936157011018 Ligand binding site; other site 936157011019 metal-binding site 936157011020 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 936157011021 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 936157011022 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 936157011023 Ligand binding site; other site 936157011024 metal-binding site 936157011025 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 936157011026 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 936157011027 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 936157011028 putative ADP-binding pocket [chemical binding]; other site 936157011029 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 936157011030 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 936157011031 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 936157011032 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 936157011033 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 936157011034 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 936157011035 putative active site [active] 936157011036 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 936157011037 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 936157011038 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 936157011039 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 936157011040 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 936157011041 active site 936157011042 (T/H)XGH motif; other site 936157011043 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 936157011044 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 936157011045 DNA binding site [nucleotide binding] 936157011046 catalytic residue [active] 936157011047 H2TH interface [polypeptide binding]; other site 936157011048 putative catalytic residues [active] 936157011049 turnover-facilitating residue; other site 936157011050 intercalation triad [nucleotide binding]; other site 936157011051 8OG recognition residue [nucleotide binding]; other site 936157011052 putative reading head residues; other site 936157011053 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 936157011054 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 936157011055 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 936157011056 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 936157011057 hypothetical protein; Reviewed; Region: PRK00024 936157011058 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 936157011059 MPN+ (JAMM) motif; other site 936157011060 Zinc-binding site [ion binding]; other site 936157011061 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 936157011062 Flavoprotein; Region: Flavoprotein; pfam02441 936157011063 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 936157011064 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 936157011065 trimer interface [polypeptide binding]; other site 936157011066 active site 936157011067 division inhibitor protein; Provisional; Region: slmA; PRK09480 936157011068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157011069 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 936157011070 active site 936157011071 ribonuclease PH; Reviewed; Region: rph; PRK00173 936157011072 Ribonuclease PH; Region: RNase_PH_bact; cd11362 936157011073 hexamer interface [polypeptide binding]; other site 936157011074 active site 936157011075 hypothetical protein; Provisional; Region: PRK11820 936157011076 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 936157011077 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 936157011078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157011079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157011080 dimerization interface [polypeptide binding]; other site 936157011081 LysR substrate binding domain; Region: LysR_substrate; pfam03466 936157011082 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 936157011083 Predicted membrane protein [Function unknown]; Region: COG2860 936157011084 UPF0126 domain; Region: UPF0126; pfam03458 936157011085 UPF0126 domain; Region: UPF0126; pfam03458 936157011086 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 936157011087 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 936157011088 nucleotide binding pocket [chemical binding]; other site 936157011089 K-X-D-G motif; other site 936157011090 catalytic site [active] 936157011091 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 936157011092 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 936157011093 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 936157011094 catalytic site [active] 936157011095 G-X2-G-X-G-K; other site 936157011096 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 936157011097 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 936157011098 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 936157011099 Zn2+ binding site [ion binding]; other site 936157011100 Mg2+ binding site [ion binding]; other site 936157011101 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 936157011102 synthetase active site [active] 936157011103 NTP binding site [chemical binding]; other site 936157011104 metal binding site [ion binding]; metal-binding site 936157011105 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 936157011106 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 936157011107 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 936157011108 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 936157011109 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 936157011110 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 936157011111 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 936157011112 generic binding surface II; other site 936157011113 ssDNA binding site; other site 936157011114 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936157011115 ATP binding site [chemical binding]; other site 936157011116 putative Mg++ binding site [ion binding]; other site 936157011117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157011118 nucleotide binding region [chemical binding]; other site 936157011119 ATP-binding site [chemical binding]; other site 936157011120 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 936157011121 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 936157011122 AsmA family; Region: AsmA; pfam05170 936157011123 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 936157011124 putative alpha-glucosidase; Provisional; Region: PRK10658 936157011125 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 936157011126 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 936157011127 active site 936157011128 homotrimer interface [polypeptide binding]; other site 936157011129 catalytic site [active] 936157011130 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 936157011131 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 936157011132 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 936157011133 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 936157011134 Transposase, Mutator family; Region: Transposase_mut; pfam00872 936157011135 MULE transposase domain; Region: MULE; pfam10551 936157011136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157011137 AAA domain; Region: AAA_23; pfam13476 936157011138 Walker A/P-loop; other site 936157011139 ATP binding site [chemical binding]; other site 936157011140 AAA domain; Region: AAA_21; pfam13304 936157011141 Methyltransferase domain; Region: Methyltransf_27; pfam13708 936157011142 Methyltransferase domain; Region: Methyltransf_27; pfam13708 936157011143 Virulence protein [General function prediction only]; Region: COG3943 936157011144 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 936157011145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 936157011146 Transposase; Region: HTH_Tnp_1; pfam01527 936157011147 Transposase; Region: HTH_Tnp_1; cl17663 936157011148 autotransport protein MisL; Provisional; Region: PRK15313 936157011149 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 936157011150 Autotransporter beta-domain; Region: Autotransporter; pfam03797 936157011151 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 936157011152 DNA binding site [nucleotide binding] 936157011153 Isochorismatase family; Region: Isochorismatase; pfam00857 936157011154 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 936157011155 catalytic triad [active] 936157011156 dimer interface [polypeptide binding]; other site 936157011157 conserved cis-peptide bond; other site 936157011158 magnesium-transporting ATPase; Provisional; Region: PRK15122 936157011159 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 936157011160 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936157011161 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 936157011162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157011163 motif II; other site 936157011164 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 936157011165 magnesium transport protein MgtC; Provisional; Region: PRK15385 936157011166 MgtC family; Region: MgtC; pfam02308 936157011167 EamA-like transporter family; Region: EamA; pfam00892 936157011168 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 936157011169 EamA-like transporter family; Region: EamA; pfam00892 936157011170 hypothetical protein; Provisional; Region: PRK09956 936157011171 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 936157011172 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 936157011173 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 936157011174 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 936157011175 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 936157011176 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 936157011177 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 936157011178 active site 936157011179 phosphorylation site [posttranslational modification] 936157011180 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 936157011181 active pocket/dimerization site; other site 936157011182 active site 936157011183 phosphorylation site [posttranslational modification] 936157011184 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 936157011185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157011186 Walker A motif; other site 936157011187 ATP binding site [chemical binding]; other site 936157011188 Walker B motif; other site 936157011189 arginine finger; other site 936157011190 Transcriptional antiterminator [Transcription]; Region: COG3933 936157011191 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 936157011192 active site 936157011193 active pocket/dimerization site; other site 936157011194 phosphorylation site [posttranslational modification] 936157011195 PRD domain; Region: PRD; pfam00874 936157011196 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 936157011197 beta-galactosidase; Region: BGL; TIGR03356 936157011198 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 936157011199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157011200 putative substrate translocation pore; other site 936157011201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 936157011202 Predicted transcriptional regulator [Transcription]; Region: COG2944 936157011203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157011204 non-specific DNA binding site [nucleotide binding]; other site 936157011205 salt bridge; other site 936157011206 sequence-specific DNA binding site [nucleotide binding]; other site 936157011207 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 936157011208 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 936157011209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157011210 putative substrate translocation pore; other site 936157011211 regulatory protein UhpC; Provisional; Region: PRK11663 936157011212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157011213 putative substrate translocation pore; other site 936157011214 sensory histidine kinase UhpB; Provisional; Region: PRK11644 936157011215 MASE1; Region: MASE1; pfam05231 936157011216 Histidine kinase; Region: HisKA_3; pfam07730 936157011217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157011218 ATP binding site [chemical binding]; other site 936157011219 Mg2+ binding site [ion binding]; other site 936157011220 G-X-G motif; other site 936157011221 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 936157011222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157011223 active site 936157011224 phosphorylation site [posttranslational modification] 936157011225 intermolecular recognition site; other site 936157011226 dimerization interface [polypeptide binding]; other site 936157011227 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157011228 DNA binding residues [nucleotide binding] 936157011229 dimerization interface [polypeptide binding]; other site 936157011230 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 936157011231 active site 936157011232 catalytic residues [active] 936157011233 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 936157011234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157011235 putative substrate translocation pore; other site 936157011236 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936157011237 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 936157011238 substrate binding site [chemical binding]; other site 936157011239 dimer interface [polypeptide binding]; other site 936157011240 ATP binding site [chemical binding]; other site 936157011241 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 936157011242 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 936157011243 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157011244 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 936157011245 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 936157011246 putative valine binding site [chemical binding]; other site 936157011247 dimer interface [polypeptide binding]; other site 936157011248 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 936157011249 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 936157011250 PYR/PP interface [polypeptide binding]; other site 936157011251 dimer interface [polypeptide binding]; other site 936157011252 TPP binding site [chemical binding]; other site 936157011253 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 936157011254 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 936157011255 TPP-binding site [chemical binding]; other site 936157011256 dimer interface [polypeptide binding]; other site 936157011257 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 936157011258 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 936157011259 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 936157011260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157011261 putative substrate translocation pore; other site 936157011262 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 936157011263 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 936157011264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157011265 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 936157011266 dimerization interface [polypeptide binding]; other site 936157011267 substrate binding pocket [chemical binding]; other site 936157011268 permease DsdX; Provisional; Region: PRK09921 936157011269 gluconate transporter; Region: gntP; TIGR00791 936157011270 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 936157011271 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 936157011272 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 936157011273 catalytic residue [active] 936157011274 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 936157011275 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 936157011276 Domain of unknown function (DUF202); Region: DUF202; pfam02656 936157011277 Predicted membrane protein [Function unknown]; Region: COG2149 936157011278 putative transporter; Validated; Region: PRK03818 936157011279 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 936157011280 TrkA-C domain; Region: TrkA_C; pfam02080 936157011281 TrkA-C domain; Region: TrkA_C; pfam02080 936157011282 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 936157011283 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 936157011284 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 936157011285 putative dimer interface [polypeptide binding]; other site 936157011286 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 936157011287 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 936157011288 putative dimer interface [polypeptide binding]; other site 936157011289 hypothetical protein; Provisional; Region: PRK11616 936157011290 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 936157011291 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 936157011292 putative bifunctional cytochrome c-type biogenesis protein ccmAE; Includes: RecName: Full=Cytochrome c biogenesis ATP-binding export protein ccmA 2; Heme exporter protein A 2; Includes: RecName: Full=Cytochrome c-type biogenesis protein ccmE 2; Cytochrome c maturation protein E 2; Heme chaperone ccmE 2;, ABC transporter, haem export, CcmA 936157011293 Haem-binding domain; Region: Haem_bd; pfam14376 936157011294 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 936157011295 chaperone protein TorD; Validated; Region: torD; PRK04976 936157011296 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 936157011297 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 936157011298 molybdopterin cofactor binding site [chemical binding]; other site 936157011299 substrate binding site [chemical binding]; other site 936157011300 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 936157011301 molybdopterin cofactor binding site; other site 936157011302 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 936157011303 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 936157011304 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 936157011305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157011306 active site 936157011307 phosphorylation site [posttranslational modification] 936157011308 intermolecular recognition site; other site 936157011309 dimerization interface [polypeptide binding]; other site 936157011310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157011311 DNA binding site [nucleotide binding] 936157011312 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 936157011313 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 936157011314 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 936157011315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157011316 dimer interface [polypeptide binding]; other site 936157011317 phosphorylation site [posttranslational modification] 936157011318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157011319 ATP binding site [chemical binding]; other site 936157011320 Mg2+ binding site [ion binding]; other site 936157011321 G-X-G motif; other site 936157011322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157011323 active site 936157011324 phosphorylation site [posttranslational modification] 936157011325 intermolecular recognition site; other site 936157011326 dimerization interface [polypeptide binding]; other site 936157011327 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 936157011328 putative binding surface; other site 936157011329 active site 936157011330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157011331 D-galactonate transporter; Region: 2A0114; TIGR00893 936157011332 putative substrate translocation pore; other site 936157011333 galactonate dehydratase; Provisional; Region: PRK14017 936157011334 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 936157011335 putative active site pocket [active] 936157011336 putative metal binding site [ion binding]; other site 936157011337 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 936157011338 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 936157011339 active site 936157011340 intersubunit interface [polypeptide binding]; other site 936157011341 catalytic residue [active] 936157011342 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 936157011343 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 936157011344 Transcriptional regulators [Transcription]; Region: FadR; COG2186 936157011345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157011346 DNA-binding site [nucleotide binding]; DNA binding site 936157011347 FCD domain; Region: FCD; pfam07729 936157011348 sugar phosphate phosphatase; Provisional; Region: PRK10513 936157011349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157011350 active site 936157011351 motif I; other site 936157011352 motif II; other site 936157011353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157011354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157011355 D-galactonate transporter; Region: 2A0114; TIGR00893 936157011356 putative substrate translocation pore; other site 936157011357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157011358 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 936157011359 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 936157011360 active site pocket [active] 936157011361 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157011362 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157011363 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 936157011364 putative dimerization interface [polypeptide binding]; other site 936157011365 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 936157011366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157011367 Mg2+ binding site [ion binding]; other site 936157011368 G-X-G motif; other site 936157011369 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 936157011370 anchoring element; other site 936157011371 dimer interface [polypeptide binding]; other site 936157011372 ATP binding site [chemical binding]; other site 936157011373 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 936157011374 active site 936157011375 putative metal-binding site [ion binding]; other site 936157011376 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 936157011377 recF protein; Region: recf; TIGR00611 936157011378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157011379 Walker A/P-loop; other site 936157011380 ATP binding site [chemical binding]; other site 936157011381 Q-loop/lid; other site 936157011382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157011383 ABC transporter signature motif; other site 936157011384 Walker B; other site 936157011385 D-loop; other site 936157011386 H-loop/switch region; other site 936157011387 DNA polymerase III subunit beta; Validated; Region: PRK05643 936157011388 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 936157011389 putative DNA binding surface [nucleotide binding]; other site 936157011390 dimer interface [polypeptide binding]; other site 936157011391 beta-clamp/clamp loader binding surface; other site 936157011392 beta-clamp/translesion DNA polymerase binding surface; other site 936157011393 DnaA N-terminal domain; Region: DnaA_N; pfam11638 936157011394 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 936157011395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157011396 Walker A motif; other site 936157011397 ATP binding site [chemical binding]; other site 936157011398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 936157011399 Walker B motif; other site 936157011400 arginine finger; other site 936157011401 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 936157011402 DnaA box-binding interface [nucleotide binding]; other site 936157011403 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 936157011404 ribonuclease P; Reviewed; Region: rnpA; PRK01732 936157011405 hypothetical protein; Validated; Region: PRK00041 936157011406 membrane protein insertase; Provisional; Region: PRK01318 936157011407 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 936157011408 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 936157011409 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 936157011410 trmE is a tRNA modification GTPase; Region: trmE; cd04164 936157011411 G1 box; other site 936157011412 GTP/Mg2+ binding site [chemical binding]; other site 936157011413 Switch I region; other site 936157011414 G2 box; other site 936157011415 Switch II region; other site 936157011416 G3 box; other site 936157011417 G4 box; other site 936157011418 G5 box; other site 936157011419 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 936157011420 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 936157011421 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 936157011422 active site 936157011423 Int/Topo IB signature motif; other site 936157011424 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 936157011425 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 936157011426 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 936157011427 putative active site [active] 936157011428 putative NTP binding site [chemical binding]; other site 936157011429 putative nucleic acid binding site [nucleotide binding]; other site 936157011430 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 936157011431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157011432 putative substrate translocation pore; other site 936157011433 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 936157011434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157011435 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 936157011436 substrate binding pocket [chemical binding]; other site 936157011437 dimerization interface [polypeptide binding]; other site 936157011438 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 936157011439 Predicted flavoprotein [General function prediction only]; Region: COG0431 936157011440 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 936157011441 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 936157011442 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 936157011443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157011444 active site 936157011445 motif I; other site 936157011446 motif II; other site 936157011447 transcriptional regulator PhoU; Provisional; Region: PRK11115 936157011448 PhoU domain; Region: PhoU; pfam01895 936157011449 PhoU domain; Region: PhoU; pfam01895 936157011450 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 936157011451 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 936157011452 Walker A/P-loop; other site 936157011453 ATP binding site [chemical binding]; other site 936157011454 Q-loop/lid; other site 936157011455 ABC transporter signature motif; other site 936157011456 Walker B; other site 936157011457 D-loop; other site 936157011458 H-loop/switch region; other site 936157011459 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 936157011460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157011461 dimer interface [polypeptide binding]; other site 936157011462 conserved gate region; other site 936157011463 putative PBP binding loops; other site 936157011464 ABC-ATPase subunit interface; other site 936157011465 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 936157011466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157011467 dimer interface [polypeptide binding]; other site 936157011468 conserved gate region; other site 936157011469 putative PBP binding loops; other site 936157011470 ABC-ATPase subunit interface; other site 936157011471 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157011472 substrate binding pocket [chemical binding]; other site 936157011473 membrane-bound complex binding site; other site 936157011474 hinge residues; other site 936157011475 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 936157011476 active site 936157011477 P-loop; other site 936157011478 phosphorylation site [posttranslational modification] 936157011479 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 936157011480 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 936157011481 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 936157011482 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 936157011483 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 936157011484 shikimate binding site; other site 936157011485 NAD(P) binding site [chemical binding]; other site 936157011486 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 936157011487 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 936157011488 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 936157011489 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 936157011490 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 936157011491 glutaminase active site [active] 936157011492 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 936157011493 dimer interface [polypeptide binding]; other site 936157011494 active site 936157011495 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 936157011496 dimer interface [polypeptide binding]; other site 936157011497 active site 936157011498 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 936157011499 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 936157011500 Substrate binding site; other site 936157011501 Mg++ binding site; other site 936157011502 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 936157011503 active site 936157011504 substrate binding site [chemical binding]; other site 936157011505 CoA binding site [chemical binding]; other site 936157011506 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 936157011507 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 936157011508 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 936157011509 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 936157011510 gamma subunit interface [polypeptide binding]; other site 936157011511 epsilon subunit interface [polypeptide binding]; other site 936157011512 LBP interface [polypeptide binding]; other site 936157011513 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 936157011514 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 936157011515 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 936157011516 alpha subunit interaction interface [polypeptide binding]; other site 936157011517 Walker A motif; other site 936157011518 ATP binding site [chemical binding]; other site 936157011519 Walker B motif; other site 936157011520 inhibitor binding site; inhibition site 936157011521 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 936157011522 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 936157011523 core domain interface [polypeptide binding]; other site 936157011524 delta subunit interface [polypeptide binding]; other site 936157011525 epsilon subunit interface [polypeptide binding]; other site 936157011526 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 936157011527 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 936157011528 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 936157011529 beta subunit interaction interface [polypeptide binding]; other site 936157011530 Walker A motif; other site 936157011531 ATP binding site [chemical binding]; other site 936157011532 Walker B motif; other site 936157011533 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 936157011534 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 936157011535 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 936157011536 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 936157011537 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 936157011538 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 936157011539 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 936157011540 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 936157011541 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 936157011542 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 936157011543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157011544 S-adenosylmethionine binding site [chemical binding]; other site 936157011545 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 936157011546 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 936157011547 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 936157011548 FMN-binding protein MioC; Provisional; Region: PRK09004 936157011549 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 936157011550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936157011551 putative DNA binding site [nucleotide binding]; other site 936157011552 putative Zn2+ binding site [ion binding]; other site 936157011553 AsnC family; Region: AsnC_trans_reg; pfam01037 936157011554 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 936157011555 dimer interface [polypeptide binding]; other site 936157011556 active site 936157011557 hypothetical protein; Provisional; Region: yieM; PRK10997 936157011558 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 936157011559 metal ion-dependent adhesion site (MIDAS); other site 936157011560 regulatory ATPase RavA; Provisional; Region: PRK13531 936157011561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157011562 Walker A motif; other site 936157011563 ATP binding site [chemical binding]; other site 936157011564 Walker B motif; other site 936157011565 arginine finger; other site 936157011566 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 936157011567 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 936157011568 potassium uptake protein; Region: kup; TIGR00794 936157011569 D-ribose pyranase; Provisional; Region: PRK11797 936157011570 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 936157011571 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 936157011572 Walker A/P-loop; other site 936157011573 ATP binding site [chemical binding]; other site 936157011574 Q-loop/lid; other site 936157011575 ABC transporter signature motif; other site 936157011576 Walker B; other site 936157011577 D-loop; other site 936157011578 H-loop/switch region; other site 936157011579 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 936157011580 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 936157011581 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 936157011582 TM-ABC transporter signature motif; other site 936157011583 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 936157011584 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 936157011585 ligand binding site [chemical binding]; other site 936157011586 dimerization interface [polypeptide binding]; other site 936157011587 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936157011588 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 936157011589 substrate binding site [chemical binding]; other site 936157011590 dimer interface [polypeptide binding]; other site 936157011591 ATP binding site [chemical binding]; other site 936157011592 transcriptional repressor RbsR; Provisional; Region: PRK10423 936157011593 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157011594 DNA binding site [nucleotide binding] 936157011595 domain linker motif; other site 936157011596 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 936157011597 dimerization interface [polypeptide binding]; other site 936157011598 ligand binding site [chemical binding]; other site 936157011599 putative transporter; Provisional; Region: PRK10504 936157011600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157011601 putative substrate translocation pore; other site 936157011602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157011603 Transcriptional regulators [Transcription]; Region: FadR; COG2186 936157011604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157011605 DNA-binding site [nucleotide binding]; DNA binding site 936157011606 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 936157011607 transcriptional regulator HdfR; Provisional; Region: PRK03601 936157011608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157011609 LysR substrate binding domain; Region: LysR_substrate; pfam03466 936157011610 dimerization interface [polypeptide binding]; other site 936157011611 hypothetical protein; Provisional; Region: PRK11027 936157011612 putative ATP-dependent protease; Provisional; Region: PRK09862 936157011613 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 936157011614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157011615 Walker A motif; other site 936157011616 ATP binding site [chemical binding]; other site 936157011617 Walker B motif; other site 936157011618 arginine finger; other site 936157011619 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 936157011620 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 936157011621 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 936157011622 PYR/PP interface [polypeptide binding]; other site 936157011623 dimer interface [polypeptide binding]; other site 936157011624 TPP binding site [chemical binding]; other site 936157011625 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 936157011626 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 936157011627 TPP-binding site [chemical binding]; other site 936157011628 dimer interface [polypeptide binding]; other site 936157011629 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 936157011630 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 936157011631 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 936157011632 homodimer interface [polypeptide binding]; other site 936157011633 substrate-cofactor binding pocket; other site 936157011634 catalytic residue [active] 936157011635 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 936157011636 threonine dehydratase; Reviewed; Region: PRK09224 936157011637 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 936157011638 tetramer interface [polypeptide binding]; other site 936157011639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157011640 catalytic residue [active] 936157011641 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 936157011642 putative Ile/Val binding site [chemical binding]; other site 936157011643 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 936157011644 putative Ile/Val binding site [chemical binding]; other site 936157011645 Phage-related protein [Function unknown]; Region: COG4679 936157011646 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 936157011647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157011648 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 936157011649 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 936157011650 putative dimerization interface [polypeptide binding]; other site 936157011651 ketol-acid reductoisomerase; Validated; Region: PRK05225 936157011652 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 936157011653 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 936157011654 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 936157011655 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 936157011656 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 936157011657 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 936157011658 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 936157011659 Part of AAA domain; Region: AAA_19; pfam13245 936157011660 Family description; Region: UvrD_C_2; pfam13538 936157011661 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 936157011662 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 936157011663 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 936157011664 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 936157011665 ATP binding site [chemical binding]; other site 936157011666 Mg++ binding site [ion binding]; other site 936157011667 motif III; other site 936157011668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157011669 nucleotide binding region [chemical binding]; other site 936157011670 ATP-binding site [chemical binding]; other site 936157011671 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 936157011672 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 936157011673 catalytic residues [active] 936157011674 transcription termination factor Rho; Provisional; Region: rho; PRK09376 936157011675 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 936157011676 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 936157011677 RNA binding site [nucleotide binding]; other site 936157011678 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 936157011679 multimer interface [polypeptide binding]; other site 936157011680 Walker A motif; other site 936157011681 ATP binding site [chemical binding]; other site 936157011682 Walker B motif; other site 936157011683 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 936157011684 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 936157011685 Mg++ binding site [ion binding]; other site 936157011686 putative catalytic motif [active] 936157011687 substrate binding site [chemical binding]; other site 936157011688 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 936157011689 Chain length determinant protein; Region: Wzz; pfam02706 936157011690 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 936157011691 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 936157011692 active site 936157011693 homodimer interface [polypeptide binding]; other site 936157011694 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 936157011695 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 936157011696 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 936157011697 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 936157011698 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 936157011699 NAD binding site [chemical binding]; other site 936157011700 substrate binding site [chemical binding]; other site 936157011701 homodimer interface [polypeptide binding]; other site 936157011702 active site 936157011703 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 936157011704 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 936157011705 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 936157011706 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 936157011707 inhibitor-cofactor binding pocket; inhibition site 936157011708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157011709 catalytic residue [active] 936157011710 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 936157011711 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 936157011712 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 936157011713 putative common antigen polymerase; Provisional; Region: PRK02975 936157011714 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 936157011715 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 936157011716 putative transport protein YifK; Provisional; Region: PRK10746 936157011717 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 936157011718 HemY protein N-terminus; Region: HemY_N; pfam07219 936157011719 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 936157011720 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 936157011721 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 936157011722 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 936157011723 active site 936157011724 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 936157011725 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 936157011726 domain interfaces; other site 936157011727 active site 936157011728 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 936157011729 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 936157011730 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 936157011731 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 936157011732 putative iron binding site [ion binding]; other site 936157011733 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 936157011734 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 936157011735 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 936157011736 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 936157011737 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 936157011738 hypothetical protein; Provisional; Region: PRK10963 936157011739 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 936157011740 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 936157011741 active site 936157011742 Int/Topo IB signature motif; other site 936157011743 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 936157011744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157011745 motif II; other site 936157011746 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 936157011747 Part of AAA domain; Region: AAA_19; pfam13245 936157011748 Family description; Region: UvrD_C_2; pfam13538 936157011749 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 936157011750 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 936157011751 Cl binding site [ion binding]; other site 936157011752 oligomer interface [polypeptide binding]; other site 936157011753 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 936157011754 hypothetical protein; Provisional; Region: PRK11371 936157011755 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 936157011756 EamA-like transporter family; Region: EamA; cl17759 936157011757 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 936157011758 CoenzymeA binding site [chemical binding]; other site 936157011759 subunit interaction site [polypeptide binding]; other site 936157011760 PHB binding site; other site 936157011761 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 936157011762 dimerization interface [polypeptide binding]; other site 936157011763 substrate binding site [chemical binding]; other site 936157011764 active site 936157011765 calcium binding site [ion binding]; other site 936157011766 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 936157011767 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936157011768 ATP binding site [chemical binding]; other site 936157011769 putative Mg++ binding site [ion binding]; other site 936157011770 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 936157011771 nucleotide binding region [chemical binding]; other site 936157011772 ATP-binding site [chemical binding]; other site 936157011773 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 936157011774 Helicase and RNase D C-terminal; Region: HRDC; smart00341 936157011775 threonine efflux system; Provisional; Region: PRK10229 936157011776 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 936157011777 lysophospholipase L2; Provisional; Region: PRK10749 936157011778 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 936157011779 putative hydrolase; Provisional; Region: PRK10976 936157011780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157011781 active site 936157011782 motif I; other site 936157011783 motif II; other site 936157011784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157011785 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 936157011786 EamA-like transporter family; Region: EamA; pfam00892 936157011787 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 936157011788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157011789 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 936157011790 putative dimerization interface [polypeptide binding]; other site 936157011791 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 936157011792 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 936157011793 THF binding site; other site 936157011794 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 936157011795 substrate binding site [chemical binding]; other site 936157011796 THF binding site; other site 936157011797 zinc-binding site [ion binding]; other site 936157011798 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 936157011799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157011800 FeS/SAM binding site; other site 936157011801 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 936157011802 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 936157011803 uridine phosphorylase; Provisional; Region: PRK11178 936157011804 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 936157011805 DNA recombination protein RmuC; Provisional; Region: PRK10361 936157011806 RmuC family; Region: RmuC; pfam02646 936157011807 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 936157011808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157011809 S-adenosylmethionine binding site [chemical binding]; other site 936157011810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 936157011811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 936157011812 SCP-2 sterol transfer family; Region: SCP2; pfam02036 936157011813 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 936157011814 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 936157011815 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 936157011816 sec-independent translocase; Provisional; Region: PRK01770 936157011817 sec-independent translocase; Provisional; Region: tatB; PRK00404 936157011818 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 936157011819 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 936157011820 active site 936157011821 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 936157011822 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 936157011823 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 936157011824 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 936157011825 FMN reductase; Validated; Region: fre; PRK08051 936157011826 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 936157011827 FAD binding pocket [chemical binding]; other site 936157011828 FAD binding motif [chemical binding]; other site 936157011829 phosphate binding motif [ion binding]; other site 936157011830 beta-alpha-beta structure motif; other site 936157011831 NAD binding pocket [chemical binding]; other site 936157011832 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 936157011833 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 936157011834 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 936157011835 dimer interface [polypeptide binding]; other site 936157011836 active site 936157011837 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 936157011838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 936157011839 substrate binding site [chemical binding]; other site 936157011840 oxyanion hole (OAH) forming residues; other site 936157011841 trimer interface [polypeptide binding]; other site 936157011842 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 936157011843 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 936157011844 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 936157011845 proline dipeptidase; Provisional; Region: PRK13607 936157011846 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 936157011847 active site 936157011848 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 936157011849 potassium transporter; Provisional; Region: PRK10750 936157011850 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 936157011851 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 936157011852 Walker A motif; other site 936157011853 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 936157011854 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 936157011855 GTP binding site; other site 936157011856 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 936157011857 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 936157011858 serine/threonine protein kinase; Provisional; Region: PRK11768 936157011859 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 936157011860 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 936157011861 catalytic residues [active] 936157011862 hinge region; other site 936157011863 alpha helical domain; other site 936157011864 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 936157011865 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 936157011866 putative acyl-acceptor binding pocket; other site 936157011867 DNA polymerase I; Provisional; Region: PRK05755 936157011868 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 936157011869 active site 936157011870 metal binding site 1 [ion binding]; metal-binding site 936157011871 putative 5' ssDNA interaction site; other site 936157011872 metal binding site 3; metal-binding site 936157011873 metal binding site 2 [ion binding]; metal-binding site 936157011874 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 936157011875 putative DNA binding site [nucleotide binding]; other site 936157011876 putative metal binding site [ion binding]; other site 936157011877 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 936157011878 active site 936157011879 catalytic site [active] 936157011880 substrate binding site [chemical binding]; other site 936157011881 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 936157011882 active site 936157011883 DNA binding site [nucleotide binding] 936157011884 catalytic site [active] 936157011885 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 936157011886 G1 box; other site 936157011887 GTP/Mg2+ binding site [chemical binding]; other site 936157011888 Switch I region; other site 936157011889 G2 box; other site 936157011890 G3 box; other site 936157011891 Switch II region; other site 936157011892 G4 box; other site 936157011893 G5 box; other site 936157011894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 936157011895 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 936157011896 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157011897 FeS/SAM binding site; other site 936157011898 HemN C-terminal domain; Region: HemN_C; pfam06969 936157011899 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 936157011900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157011901 active site 936157011902 phosphorylation site [posttranslational modification] 936157011903 intermolecular recognition site; other site 936157011904 dimerization interface [polypeptide binding]; other site 936157011905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157011906 Walker A motif; other site 936157011907 ATP binding site [chemical binding]; other site 936157011908 Walker B motif; other site 936157011909 arginine finger; other site 936157011910 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 936157011911 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 936157011912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 936157011913 putative active site [active] 936157011914 heme pocket [chemical binding]; other site 936157011915 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157011916 dimer interface [polypeptide binding]; other site 936157011917 phosphorylation site [posttranslational modification] 936157011918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157011919 ATP binding site [chemical binding]; other site 936157011920 Mg2+ binding site [ion binding]; other site 936157011921 G-X-G motif; other site 936157011922 glutamine synthetase; Provisional; Region: glnA; PRK09469 936157011923 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 936157011924 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 936157011925 GTP-binding protein; Provisional; Region: PRK10218 936157011926 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 936157011927 G1 box; other site 936157011928 putative GEF interaction site [polypeptide binding]; other site 936157011929 GTP/Mg2+ binding site [chemical binding]; other site 936157011930 Switch I region; other site 936157011931 G2 box; other site 936157011932 G3 box; other site 936157011933 Switch II region; other site 936157011934 G4 box; other site 936157011935 G5 box; other site 936157011936 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 936157011937 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 936157011938 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 936157011939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157011940 active site 936157011941 motif I; other site 936157011942 motif II; other site 936157011943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157011944 coproporphyrinogen III oxidase; Validated; Region: PRK08208 936157011945 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157011946 FeS/SAM binding site; other site 936157011947 HemN C-terminal domain; Region: HemN_C; pfam06969 936157011948 Sulfatase; Region: Sulfatase; cl17466 936157011949 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 936157011950 outer membrane porin L; Provisional; Region: ompL; PRK09980 936157011951 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 936157011952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157011953 putative substrate translocation pore; other site 936157011954 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 936157011955 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 936157011956 alpha-glucosidase; Provisional; Region: PRK10426 936157011957 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 936157011958 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 936157011959 putative active site [active] 936157011960 putative catalytic site [active] 936157011961 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 936157011962 active site 936157011963 catalytic residues [active] 936157011964 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 936157011965 dimerization interface [polypeptide binding]; other site 936157011966 putative active cleft [active] 936157011967 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 936157011968 catalytic residue [active] 936157011969 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 936157011970 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 936157011971 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936157011972 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 936157011973 substrate binding site [chemical binding]; other site 936157011974 ATP binding site [chemical binding]; other site 936157011975 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936157011976 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 936157011977 putative DNA binding site [nucleotide binding]; other site 936157011978 putative Zn2+ binding site [ion binding]; other site 936157011979 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157011980 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 936157011981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157011982 motif II; other site 936157011983 hypothetical protein; Reviewed; Region: PRK01637 936157011984 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 936157011985 putative active site [active] 936157011986 dimerization interface [polypeptide binding]; other site 936157011987 putative tRNAtyr binding site [nucleotide binding]; other site 936157011988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157011989 Coenzyme A binding pocket [chemical binding]; other site 936157011990 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 936157011991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157011992 non-specific DNA binding site [nucleotide binding]; other site 936157011993 salt bridge; other site 936157011994 sequence-specific DNA binding site [nucleotide binding]; other site 936157011995 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 936157011996 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 936157011997 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 936157011998 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 936157011999 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 936157012000 oligomeric interface; other site 936157012001 putative active site [active] 936157012002 homodimer interface [polypeptide binding]; other site 936157012003 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 936157012004 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 936157012005 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 936157012006 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 936157012007 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 936157012008 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 936157012009 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 936157012010 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 936157012011 molybdopterin cofactor binding site; other site 936157012012 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157012013 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157012014 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157012015 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 936157012016 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 936157012017 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 936157012018 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 936157012019 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 936157012020 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936157012021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157012022 non-specific DNA binding site [nucleotide binding]; other site 936157012023 salt bridge; other site 936157012024 sequence-specific DNA binding site [nucleotide binding]; other site 936157012025 Cupin domain; Region: Cupin_2; cl17218 936157012026 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 936157012027 lactaldehyde reductase; Region: lactal_redase; TIGR02638 936157012028 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 936157012029 dimer interface [polypeptide binding]; other site 936157012030 active site 936157012031 metal binding site [ion binding]; metal-binding site 936157012032 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 936157012033 intersubunit interface [polypeptide binding]; other site 936157012034 active site 936157012035 Zn2+ binding site [ion binding]; other site 936157012036 L-rhamnose isomerase; Provisional; Region: PRK01076 936157012037 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 936157012038 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 936157012039 N- and C-terminal domain interface [polypeptide binding]; other site 936157012040 active site 936157012041 putative catalytic site [active] 936157012042 metal binding site [ion binding]; metal-binding site 936157012043 ATP binding site [chemical binding]; other site 936157012044 rhamnulokinase; Provisional; Region: rhaB; PRK10640 936157012045 carbohydrate binding site [chemical binding]; other site 936157012046 transcriptional activator RhaS; Provisional; Region: PRK13503 936157012047 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 936157012048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157012049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157012050 transcriptional activator RhaR; Provisional; Region: PRK13502 936157012051 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 936157012052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157012053 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 936157012054 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 936157012055 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 936157012056 DctM-like transporters; Region: DctM; pfam06808 936157012057 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 936157012058 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 936157012059 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 936157012060 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 936157012061 superoxide dismutase; Provisional; Region: PRK10925 936157012062 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 936157012063 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 936157012064 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 936157012065 MOSC domain; Region: MOSC; pfam03473 936157012066 3-alpha domain; Region: 3-alpha; pfam03475 936157012067 SnoaL-like domain; Region: SnoaL_2; pfam12680 936157012068 two-component sensor protein; Provisional; Region: cpxA; PRK09470 936157012069 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157012070 dimerization interface [polypeptide binding]; other site 936157012071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157012072 dimer interface [polypeptide binding]; other site 936157012073 phosphorylation site [posttranslational modification] 936157012074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157012075 ATP binding site [chemical binding]; other site 936157012076 Mg2+ binding site [ion binding]; other site 936157012077 G-X-G motif; other site 936157012078 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 936157012079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157012080 active site 936157012081 intermolecular recognition site; other site 936157012082 dimerization interface [polypeptide binding]; other site 936157012083 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157012084 DNA binding site [nucleotide binding] 936157012085 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 936157012086 dimer interface [polypeptide binding]; other site 936157012087 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 936157012088 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 936157012089 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 936157012090 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 936157012091 active site 936157012092 ADP/pyrophosphate binding site [chemical binding]; other site 936157012093 dimerization interface [polypeptide binding]; other site 936157012094 allosteric effector site; other site 936157012095 fructose-1,6-bisphosphate binding site; other site 936157012096 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 936157012097 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157012098 substrate binding pocket [chemical binding]; other site 936157012099 membrane-bound complex binding site; other site 936157012100 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 936157012101 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 936157012102 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 936157012103 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936157012104 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 936157012105 putative substrate binding site [chemical binding]; other site 936157012106 putative ATP binding site [chemical binding]; other site 936157012107 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 936157012108 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 936157012109 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 936157012110 DNA-binding site [nucleotide binding]; DNA binding site 936157012111 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 936157012112 UTRA domain; Region: UTRA; pfam07702 936157012113 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 936157012114 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 936157012115 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 936157012116 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 936157012117 putative N- and C-terminal domain interface [polypeptide binding]; other site 936157012118 putative active site [active] 936157012119 putative MgATP binding site [chemical binding]; other site 936157012120 catalytic site [active] 936157012121 metal binding site [ion binding]; metal-binding site 936157012122 putative carbohydrate binding site [chemical binding]; other site 936157012123 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 936157012124 transcriptional regulator LsrR; Provisional; Region: PRK15418 936157012125 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 936157012126 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 936157012127 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 936157012128 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 936157012129 Walker A/P-loop; other site 936157012130 ATP binding site [chemical binding]; other site 936157012131 Q-loop/lid; other site 936157012132 ABC transporter signature motif; other site 936157012133 Walker B; other site 936157012134 D-loop; other site 936157012135 H-loop/switch region; other site 936157012136 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 936157012137 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 936157012138 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 936157012139 TM-ABC transporter signature motif; other site 936157012140 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 936157012141 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 936157012142 ligand binding site [chemical binding]; other site 936157012143 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 936157012144 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 936157012145 putative active site; other site 936157012146 catalytic residue [active] 936157012147 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 936157012148 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 936157012149 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 936157012150 substrate binding site [chemical binding]; other site 936157012151 hexamer interface [polypeptide binding]; other site 936157012152 metal binding site [ion binding]; metal-binding site 936157012153 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 936157012154 triosephosphate isomerase; Provisional; Region: PRK14567 936157012155 substrate binding site [chemical binding]; other site 936157012156 dimer interface [polypeptide binding]; other site 936157012157 catalytic triad [active] 936157012158 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 936157012159 Predicted membrane protein [Function unknown]; Region: COG3152 936157012160 ferredoxin-NADP reductase; Provisional; Region: PRK10926 936157012161 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 936157012162 FAD binding pocket [chemical binding]; other site 936157012163 FAD binding motif [chemical binding]; other site 936157012164 phosphate binding motif [ion binding]; other site 936157012165 beta-alpha-beta structure motif; other site 936157012166 NAD binding pocket [chemical binding]; other site 936157012167 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 936157012168 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 936157012169 putative active site [active] 936157012170 glycerol kinase; Provisional; Region: glpK; PRK00047 936157012171 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 936157012172 N- and C-terminal domain interface [polypeptide binding]; other site 936157012173 active site 936157012174 MgATP binding site [chemical binding]; other site 936157012175 catalytic site [active] 936157012176 metal binding site [ion binding]; metal-binding site 936157012177 glycerol binding site [chemical binding]; other site 936157012178 homotetramer interface [polypeptide binding]; other site 936157012179 homodimer interface [polypeptide binding]; other site 936157012180 FBP binding site [chemical binding]; other site 936157012181 protein IIAGlc interface [polypeptide binding]; other site 936157012182 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 936157012183 amphipathic channel; other site 936157012184 Asn-Pro-Ala signature motifs; other site 936157012185 septal ring assembly protein ZapB; Provisional; Region: PRK15422 936157012186 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 936157012187 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 936157012188 UbiA prenyltransferase family; Region: UbiA; pfam01040 936157012189 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 936157012190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157012191 Walker A motif; other site 936157012192 ATP binding site [chemical binding]; other site 936157012193 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 936157012194 Walker B motif; other site 936157012195 arginine finger; other site 936157012196 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 936157012197 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 936157012198 active site 936157012199 HslU subunit interaction site [polypeptide binding]; other site 936157012200 essential cell division protein FtsN; Provisional; Region: PRK10927 936157012201 cell division protein FtsN; Provisional; Region: PRK12757 936157012202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157012203 DNA binding site [nucleotide binding] 936157012204 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 936157012205 domain linker motif; other site 936157012206 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 936157012207 dimerization interface [polypeptide binding]; other site 936157012208 ligand binding site [chemical binding]; other site 936157012209 primosome assembly protein PriA; Validated; Region: PRK05580 936157012210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936157012211 ATP binding site [chemical binding]; other site 936157012212 putative Mg++ binding site [ion binding]; other site 936157012213 helicase superfamily c-terminal domain; Region: HELICc; smart00490 936157012214 ATP-binding site [chemical binding]; other site 936157012215 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 936157012216 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 936157012217 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 936157012218 dimerization interface [polypeptide binding]; other site 936157012219 DNA binding site [nucleotide binding] 936157012220 corepressor binding sites; other site 936157012221 cystathionine gamma-synthase; Provisional; Region: PRK08045 936157012222 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 936157012223 homodimer interface [polypeptide binding]; other site 936157012224 substrate-cofactor binding pocket; other site 936157012225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157012226 catalytic residue [active] 936157012227 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 936157012228 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 936157012229 putative catalytic residues [active] 936157012230 putative nucleotide binding site [chemical binding]; other site 936157012231 putative aspartate binding site [chemical binding]; other site 936157012232 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 936157012233 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 936157012234 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 936157012235 mechanosensitive channel MscS; Provisional; Region: PRK10334 936157012236 Conserved TM helix; Region: TM_helix; pfam05552 936157012237 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936157012238 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 936157012239 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 936157012240 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 936157012241 active site 936157012242 metal binding site [ion binding]; metal-binding site 936157012243 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 936157012244 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 936157012245 FAD binding site [chemical binding]; other site 936157012246 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 936157012247 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 936157012248 heme binding site [chemical binding]; other site 936157012249 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 936157012250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 936157012251 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 936157012252 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 936157012253 dimer interface [polypeptide binding]; other site 936157012254 active site 936157012255 metal binding site [ion binding]; metal-binding site 936157012256 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 936157012257 active site 936157012258 intersubunit interactions; other site 936157012259 catalytic residue [active] 936157012260 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936157012261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157012262 hypothetical protein; Provisional; Region: PRK10649 936157012263 Sulfatase; Region: Sulfatase; pfam00884 936157012264 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 936157012265 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 936157012266 acetylornithine deacetylase; Provisional; Region: PRK05111 936157012267 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 936157012268 metal binding site [ion binding]; metal-binding site 936157012269 putative dimer interface [polypeptide binding]; other site 936157012270 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 936157012271 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 936157012272 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 936157012273 nucleotide binding site [chemical binding]; other site 936157012274 N-acetyl-L-glutamate binding site [chemical binding]; other site 936157012275 argininosuccinate lyase; Provisional; Region: PRK04833 936157012276 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 936157012277 active sites [active] 936157012278 tetramer interface [polypeptide binding]; other site 936157012279 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 936157012280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157012281 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 936157012282 dimerization interface [polypeptide binding]; other site 936157012283 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 936157012284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936157012285 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 936157012286 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 936157012287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157012288 hypothetical protein; Provisional; Region: PRK11056 936157012289 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 936157012290 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 936157012291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157012292 S-adenosylmethionine binding site [chemical binding]; other site 936157012293 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 936157012294 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 936157012295 N-terminal plug; other site 936157012296 ligand-binding site [chemical binding]; other site 936157012297 glutamate racemase; Provisional; Region: PRK00865 936157012298 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 936157012299 FAD binding domain; Region: FAD_binding_4; pfam01565 936157012300 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 936157012301 Biotin operon repressor [Transcription]; Region: BirA; COG1654 936157012302 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 936157012303 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 936157012304 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 936157012305 pantothenate kinase; Provisional; Region: PRK05439 936157012306 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 936157012307 ATP-binding site [chemical binding]; other site 936157012308 CoA-binding site [chemical binding]; other site 936157012309 Mg2+-binding site [ion binding]; other site 936157012310 Elongation factor Tu; EF-Tu;, Elongation factor Tu GTP binding domain, EF-Tu: translation elongation factor Tu, Translation elongation factor EFTu/EF1A, bacterial_organelle 936157012311 putative surface-exposed virulence protein bigA; Flags: Precursor 936157012312 siroheme synthase; Provisional; Region: cysG; PRK10637 936157012313 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 936157012314 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 936157012315 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 936157012316 active site 936157012317 SAM binding site [chemical binding]; other site 936157012318 homodimer interface [polypeptide binding]; other site 936157012319 nitrite transporter NirC; Provisional; Region: PRK11562 936157012320 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 936157012321 nitrite reductase subunit NirD; Provisional; Region: PRK14989 936157012322 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 936157012323 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 936157012324 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 936157012325 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 936157012326 putative transporter; Provisional; Region: PRK03699 936157012327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157012328 putative substrate translocation pore; other site 936157012329 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 936157012330 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 936157012331 substrate binding site [chemical binding]; other site 936157012332 hypothetical protein; Provisional; Region: PRK10204 936157012333 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 936157012334 cell filamentation protein Fic; Provisional; Region: PRK10347 936157012335 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 936157012336 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 936157012337 glutamine binding [chemical binding]; other site 936157012338 catalytic triad [active] 936157012339 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 936157012340 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 936157012341 inhibitor-cofactor binding pocket; inhibition site 936157012342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157012343 catalytic residue [active] 936157012344 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 936157012345 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 936157012346 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 936157012347 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 936157012348 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 936157012349 ligand binding site [chemical binding]; other site 936157012350 flexible hinge region; other site 936157012351 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 936157012352 putative switch regulator; other site 936157012353 non-specific DNA interactions [nucleotide binding]; other site 936157012354 DNA binding site [nucleotide binding] 936157012355 sequence specific DNA binding site [nucleotide binding]; other site 936157012356 putative cAMP binding site [chemical binding]; other site 936157012357 hypothetical protein; Provisional; Region: PRK10738 936157012358 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 936157012359 active site 936157012360 hypothetical protein; Provisional; Region: PRK04966 936157012361 putative hydrolase; Provisional; Region: PRK10985 936157012362 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 936157012363 putative monooxygenase; Provisional; Region: PRK11118 936157012364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157012365 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 936157012366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157012367 Walker A/P-loop; other site 936157012368 ATP binding site [chemical binding]; other site 936157012369 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936157012370 ABC transporter signature motif; other site 936157012371 Walker B; other site 936157012372 D-loop; other site 936157012373 ABC transporter; Region: ABC_tran_2; pfam12848 936157012374 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936157012375 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 936157012376 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 936157012377 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 936157012378 TrkA-N domain; Region: TrkA_N; pfam02254 936157012379 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 936157012380 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 936157012381 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 936157012382 phi X174 lysis protein; Provisional; Region: PRK02793 936157012383 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 936157012384 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 936157012385 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 936157012386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 936157012387 YheO-like PAS domain; Region: PAS_6; pfam08348 936157012388 HTH domain; Region: HTH_22; pfam13309 936157012389 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 936157012390 sulfur relay protein TusC; Validated; Region: PRK00211 936157012391 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 936157012392 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 936157012393 S17 interaction site [polypeptide binding]; other site 936157012394 S8 interaction site; other site 936157012395 16S rRNA interaction site [nucleotide binding]; other site 936157012396 streptomycin interaction site [chemical binding]; other site 936157012397 23S rRNA interaction site [nucleotide binding]; other site 936157012398 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 936157012399 30S ribosomal protein S7; Validated; Region: PRK05302 936157012400 elongation factor G; Reviewed; Region: PRK00007 936157012401 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 936157012402 G1 box; other site 936157012403 putative GEF interaction site [polypeptide binding]; other site 936157012404 GTP/Mg2+ binding site [chemical binding]; other site 936157012405 Switch I region; other site 936157012406 G2 box; other site 936157012407 G3 box; other site 936157012408 Switch II region; other site 936157012409 G4 box; other site 936157012410 G5 box; other site 936157012411 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 936157012412 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 936157012413 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 936157012414 elongation factor Tu; Reviewed; Region: PRK00049 936157012415 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 936157012416 G1 box; other site 936157012417 GEF interaction site [polypeptide binding]; other site 936157012418 GTP/Mg2+ binding site [chemical binding]; other site 936157012419 Switch I region; other site 936157012420 G2 box; other site 936157012421 G3 box; other site 936157012422 Switch II region; other site 936157012423 G4 box; other site 936157012424 G5 box; other site 936157012425 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 936157012426 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 936157012427 Antibiotic Binding Site [chemical binding]; other site 936157012428 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 936157012429 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 936157012430 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 936157012431 putative homodimer interface [polypeptide binding]; other site 936157012432 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 936157012433 heterodimer interface [polypeptide binding]; other site 936157012434 homodimer interface [polypeptide binding]; other site 936157012435 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 936157012436 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 936157012437 23S rRNA interface [nucleotide binding]; other site 936157012438 L7/L12 interface [polypeptide binding]; other site 936157012439 putative thiostrepton binding site; other site 936157012440 L25 interface [polypeptide binding]; other site 936157012441 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 936157012442 mRNA/rRNA interface [nucleotide binding]; other site 936157012443 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 936157012444 23S rRNA interface [nucleotide binding]; other site 936157012445 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 936157012446 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 936157012447 core dimer interface [polypeptide binding]; other site 936157012448 peripheral dimer interface [polypeptide binding]; other site 936157012449 L10 interface [polypeptide binding]; other site 936157012450 L11 interface [polypeptide binding]; other site 936157012451 putative EF-Tu interaction site [polypeptide binding]; other site 936157012452 putative EF-G interaction site [polypeptide binding]; other site 936157012453 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 936157012454 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 936157012455 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 936157012456 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 936157012457 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 936157012458 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 936157012459 RPB3 interaction site [polypeptide binding]; other site 936157012460 RPB1 interaction site [polypeptide binding]; other site 936157012461 RPB11 interaction site [polypeptide binding]; other site 936157012462 RPB10 interaction site [polypeptide binding]; other site 936157012463 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 936157012464 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 936157012465 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 936157012466 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 936157012467 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 936157012468 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 936157012469 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 936157012470 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 936157012471 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 936157012472 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 936157012473 DNA binding site [nucleotide binding] 936157012474 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 936157012475 type III secretion system protein; Provisional; Region: PRK15384 936157012476 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 936157012477 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 936157012478 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157012479 FeS/SAM binding site; other site 936157012480 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 936157012481 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 936157012482 ThiS interaction site; other site 936157012483 putative active site [active] 936157012484 tetramer interface [polypeptide binding]; other site 936157012485 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 936157012486 thiS-thiF/thiG interaction site; other site 936157012487 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 936157012488 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 936157012489 ATP binding site [chemical binding]; other site 936157012490 substrate interface [chemical binding]; other site 936157012491 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 936157012492 thiamine phosphate binding site [chemical binding]; other site 936157012493 active site 936157012494 pyrophosphate binding site [ion binding]; other site 936157012495 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 936157012496 ThiC-associated domain; Region: ThiC-associated; pfam13667 936157012497 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 936157012498 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 936157012499 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 936157012500 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 936157012501 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 936157012502 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 936157012503 putative NADH binding site [chemical binding]; other site 936157012504 putative active site [active] 936157012505 nudix motif; other site 936157012506 putative metal binding site [ion binding]; other site 936157012507 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 936157012508 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 936157012509 substrate binding site [chemical binding]; other site 936157012510 active site 936157012511 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 936157012512 Active_site [active] 936157012513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 936157012514 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 936157012515 IHF - DNA interface [nucleotide binding]; other site 936157012516 IHF dimer interface [polypeptide binding]; other site 936157012517 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 936157012518 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 936157012519 dimer interface [polypeptide binding]; other site 936157012520 sensor protein ZraS; Provisional; Region: PRK10364 936157012521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157012522 dimer interface [polypeptide binding]; other site 936157012523 phosphorylation site [posttranslational modification] 936157012524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157012525 ATP binding site [chemical binding]; other site 936157012526 Mg2+ binding site [ion binding]; other site 936157012527 G-X-G motif; other site 936157012528 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 936157012529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157012530 active site 936157012531 phosphorylation site [posttranslational modification] 936157012532 intermolecular recognition site; other site 936157012533 dimerization interface [polypeptide binding]; other site 936157012534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157012535 Walker A motif; other site 936157012536 ATP binding site [chemical binding]; other site 936157012537 Walker B motif; other site 936157012538 arginine finger; other site 936157012539 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 936157012540 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 936157012541 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 936157012542 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 936157012543 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 936157012544 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 936157012545 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 936157012546 purine monophosphate binding site [chemical binding]; other site 936157012547 dimer interface [polypeptide binding]; other site 936157012548 putative catalytic residues [active] 936157012549 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 936157012550 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 936157012551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157012552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 936157012553 Coenzyme A binding pocket [chemical binding]; other site 936157012554 homoserine O-succinyltransferase; Provisional; Region: PRK05368 936157012555 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 936157012556 proposed active site lysine [active] 936157012557 conserved cys residue [active] 936157012558 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 936157012559 malate synthase A; Region: malate_syn_A; TIGR01344 936157012560 active site 936157012561 isocitrate lyase; Provisional; Region: PRK15063 936157012562 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 936157012563 tetramer interface [polypeptide binding]; other site 936157012564 active site 936157012565 Mg2+/Mn2+ binding site [ion binding]; other site 936157012566 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 936157012567 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 936157012568 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 936157012569 transcriptional repressor IclR; Provisional; Region: PRK11569 936157012570 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 936157012571 Bacterial transcriptional regulator; Region: IclR; pfam01614 936157012572 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 936157012573 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 936157012574 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 936157012575 substrate binding pocket [chemical binding]; other site 936157012576 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 936157012577 B12 binding site [chemical binding]; other site 936157012578 cobalt ligand [ion binding]; other site 936157012579 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 936157012580 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 936157012581 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 936157012582 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 936157012583 active site pocket [active] 936157012584 oxyanion hole [active] 936157012585 catalytic triad [active] 936157012586 active site nucleophile [active] 936157012587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 936157012588 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 936157012589 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 936157012590 RNA binding surface [nucleotide binding]; other site 936157012591 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 936157012592 probable active site [active] 936157012593 hypothetical protein; Provisional; Region: PRK10515 936157012594 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936157012595 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 936157012596 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157012597 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 936157012598 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 936157012599 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 936157012600 active site 936157012601 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 936157012602 phosphate binding site [ion binding]; other site 936157012603 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936157012604 aspartate kinase III; Validated; Region: PRK09084 936157012605 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 936157012606 nucleotide binding site [chemical binding]; other site 936157012607 substrate binding site [chemical binding]; other site 936157012608 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 936157012609 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 936157012610 dimer interface [polypeptide binding]; other site 936157012611 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 936157012612 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 936157012613 active site 936157012614 dimer interface [polypeptide binding]; other site 936157012615 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 936157012616 dimer interface [polypeptide binding]; other site 936157012617 active site 936157012618 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 936157012619 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 936157012620 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 936157012621 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 936157012622 Predicted membrane protein [Function unknown]; Region: COG3223 936157012623 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 936157012624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157012625 dimer interface [polypeptide binding]; other site 936157012626 conserved gate region; other site 936157012627 putative PBP binding loops; other site 936157012628 ABC-ATPase subunit interface; other site 936157012629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 936157012630 dimer interface [polypeptide binding]; other site 936157012631 conserved gate region; other site 936157012632 putative PBP binding loops; other site 936157012633 ABC-ATPase subunit interface; other site 936157012634 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 936157012635 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 936157012636 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 936157012637 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 936157012638 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 936157012639 Walker A/P-loop; other site 936157012640 ATP binding site [chemical binding]; other site 936157012641 Q-loop/lid; other site 936157012642 ABC transporter signature motif; other site 936157012643 Walker B; other site 936157012644 D-loop; other site 936157012645 H-loop/switch region; other site 936157012646 TOBE domain; Region: TOBE_2; pfam08402 936157012647 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 936157012648 trimer interface; other site 936157012649 sugar binding site [chemical binding]; other site 936157012650 maltose regulon periplasmic protein; Provisional; Region: PRK10564 936157012651 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 936157012652 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 936157012653 UbiA prenyltransferase family; Region: UbiA; pfam01040 936157012654 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 936157012655 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 936157012656 putative acyl-acceptor binding pocket; other site 936157012657 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 936157012658 LexA repressor; Validated; Region: PRK00215 936157012659 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 936157012660 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 936157012661 Catalytic site [active] 936157012662 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 936157012663 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 936157012664 hypothetical protein; Provisional; Region: PRK10428 936157012665 Transposase, Mutator family; Region: Transposase_mut; pfam00872 936157012666 MULE transposase domain; Region: MULE; pfam10551 936157012667 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 936157012668 metal binding site 2 [ion binding]; metal-binding site 936157012669 putative DNA binding helix; other site 936157012670 metal binding site 1 [ion binding]; metal-binding site 936157012671 dimer interface [polypeptide binding]; other site 936157012672 structural Zn2+ binding site [ion binding]; other site 936157012673 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 936157012674 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 936157012675 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 936157012676 FMN binding site [chemical binding]; other site 936157012677 active site 936157012678 catalytic residues [active] 936157012679 substrate binding site [chemical binding]; other site 936157012680 phage shock protein G; Reviewed; Region: pspG; PRK09459 936157012681 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 936157012682 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 936157012683 NADP binding site [chemical binding]; other site 936157012684 dimer interface [polypeptide binding]; other site 936157012685 replicative DNA helicase; Provisional; Region: PRK08006 936157012686 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 936157012687 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 936157012688 Walker A motif; other site 936157012689 ATP binding site [chemical binding]; other site 936157012690 Walker B motif; other site 936157012691 DNA binding loops [nucleotide binding] 936157012692 alanine racemase; Reviewed; Region: alr; PRK00053 936157012693 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 936157012694 active site 936157012695 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936157012696 substrate binding site [chemical binding]; other site 936157012697 catalytic residues [active] 936157012698 dimer interface [polypeptide binding]; other site 936157012699 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 936157012700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 936157012701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157012702 homodimer interface [polypeptide binding]; other site 936157012703 catalytic residue [active] 936157012704 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 936157012705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157012706 active site 936157012707 motif I; other site 936157012708 motif II; other site 936157012709 Uncharacterized conserved protein [Function unknown]; Region: COG0432 936157012710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 936157012711 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 936157012712 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 936157012713 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 936157012714 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 936157012715 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 936157012716 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 936157012717 dimer interface [polypeptide binding]; other site 936157012718 ssDNA binding site [nucleotide binding]; other site 936157012719 tetramer (dimer of dimers) interface [polypeptide binding]; other site 936157012720 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 936157012721 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 936157012722 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 936157012723 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 936157012724 HlyD family secretion protein; Region: HlyD_3; pfam13437 936157012725 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012726 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012727 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012728 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012729 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012730 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 936157012731 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 936157012732 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012733 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 936157012734 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012735 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 936157012736 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 936157012737 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012738 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 936157012739 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 936157012740 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012741 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 936157012742 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012743 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 936157012744 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 936157012745 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012746 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 936157012747 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 936157012748 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012749 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 936157012750 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012751 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012752 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 936157012753 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012754 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012755 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012756 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012757 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012758 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012759 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 936157012760 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012761 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 936157012762 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012763 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012764 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 936157012765 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 936157012766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 936157012767 Walker A/P-loop; other site 936157012768 ATP binding site [chemical binding]; other site 936157012769 Q-loop/lid; other site 936157012770 ABC transporter signature motif; other site 936157012771 Walker B; other site 936157012772 D-loop; other site 936157012773 H-loop/switch region; other site 936157012774 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 936157012775 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 936157012776 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 936157012777 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 936157012778 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157012779 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 936157012780 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 936157012781 DNA binding residues [nucleotide binding] 936157012782 dimer interface [polypeptide binding]; other site 936157012783 [2Fe-2S] cluster binding site [ion binding]; other site 936157012784 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 936157012785 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 936157012786 putative C-terminal domain interface [polypeptide binding]; other site 936157012787 putative GSH binding site (G-site) [chemical binding]; other site 936157012788 putative dimer interface [polypeptide binding]; other site 936157012789 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 936157012790 putative N-terminal domain interface [polypeptide binding]; other site 936157012791 putative dimer interface [polypeptide binding]; other site 936157012792 putative substrate binding pocket (H-site) [chemical binding]; other site 936157012793 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 936157012794 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 936157012795 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 936157012796 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157012797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157012798 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 936157012799 putative dimerization interface [polypeptide binding]; other site 936157012800 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 936157012801 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 936157012802 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 936157012803 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 936157012804 Na binding site [ion binding]; other site 936157012805 Predicted membrane protein [Function unknown]; Region: COG3162 936157012806 acetyl-CoA synthetase; Provisional; Region: PRK00174 936157012807 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 936157012808 active site 936157012809 CoA binding site [chemical binding]; other site 936157012810 acyl-activating enzyme (AAE) consensus motif; other site 936157012811 AMP binding site [chemical binding]; other site 936157012812 acetate binding site [chemical binding]; other site 936157012813 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 936157012814 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 936157012815 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 936157012816 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 936157012817 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 936157012818 heme lyase subunit NrfE; Provisional; Region: PRK10369 936157012819 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 936157012820 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 936157012821 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 936157012822 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 936157012823 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 936157012824 Sel1-like repeats; Region: SEL1; smart00671 936157012825 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157012826 molybdopterin cofactor binding site; other site 936157012827 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 936157012828 molybdopterin cofactor binding site; other site 936157012829 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 936157012830 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 936157012831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157012832 Coenzyme A binding pocket [chemical binding]; other site 936157012833 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 936157012834 dimer interface [polypeptide binding]; other site 936157012835 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 936157012836 hypothetical protein; Provisional; Region: PRK10220 936157012837 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 936157012838 PhnA protein; Region: PhnA; pfam03831 936157012839 proline/glycine betaine transporter; Provisional; Region: PRK10642 936157012840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157012841 putative substrate translocation pore; other site 936157012842 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 936157012843 sensor protein BasS/PmrB; Provisional; Region: PRK10755 936157012844 HAMP domain; Region: HAMP; pfam00672 936157012845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157012846 dimer interface [polypeptide binding]; other site 936157012847 phosphorylation site [posttranslational modification] 936157012848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157012849 ATP binding site [chemical binding]; other site 936157012850 Mg2+ binding site [ion binding]; other site 936157012851 G-X-G motif; other site 936157012852 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 936157012853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157012854 active site 936157012855 phosphorylation site [posttranslational modification] 936157012856 intermolecular recognition site; other site 936157012857 dimerization interface [polypeptide binding]; other site 936157012858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157012859 DNA binding site [nucleotide binding] 936157012860 putative metal dependent hydrolase; Provisional; Region: PRK11598 936157012861 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 936157012862 Sulfatase; Region: Sulfatase; pfam00884 936157012863 arginine:agmatin antiporter; Provisional; Region: PRK10644 936157012864 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 936157012865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157012866 arginine decarboxylase; Provisional; Region: PRK15029 936157012867 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 936157012868 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 936157012869 homodimer interface [polypeptide binding]; other site 936157012870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157012871 catalytic residue [active] 936157012872 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 936157012873 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 936157012874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157012875 alpha-galactosidase; Provisional; Region: PRK15076 936157012876 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 936157012877 NAD binding site [chemical binding]; other site 936157012878 sugar binding site [chemical binding]; other site 936157012879 divalent metal binding site [ion binding]; other site 936157012880 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 936157012881 dimer interface [polypeptide binding]; other site 936157012882 melibiose:sodium symporter; Provisional; Region: PRK10429 936157012883 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 936157012884 fumarate hydratase; Provisional; Region: PRK15389 936157012885 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 936157012886 Fumarase C-terminus; Region: Fumerase_C; pfam05683 936157012887 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 936157012888 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 936157012889 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 936157012890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157012891 active site 936157012892 phosphorylation site [posttranslational modification] 936157012893 intermolecular recognition site; other site 936157012894 dimerization interface [polypeptide binding]; other site 936157012895 sensory histidine kinase DcuS; Provisional; Region: PRK11086 936157012896 PAS domain; Region: PAS; smart00091 936157012897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157012898 ATP binding site [chemical binding]; other site 936157012899 Mg2+ binding site [ion binding]; other site 936157012900 G-X-G motif; other site 936157012901 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 936157012902 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 936157012903 putative [Fe4-S4] binding site [ion binding]; other site 936157012904 putative molybdopterin cofactor binding site [chemical binding]; other site 936157012905 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 936157012906 putative molybdopterin cofactor binding site; other site 936157012907 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 936157012908 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 936157012909 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 936157012910 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 936157012911 SdiA-regulated; Region: SdiA-regulated; pfam06977 936157012912 SdiA-regulated; Region: SdiA-regulated; cd09971 936157012913 putative active site [active] 936157012914 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936157012915 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157012916 DNA binding residues [nucleotide binding] 936157012917 dimerization interface [polypeptide binding]; other site 936157012918 AraC family transcriptional regulator; Provisional; Region: PRK15186 936157012919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157012920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 936157012921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157012922 Coenzyme A binding pocket [chemical binding]; other site 936157012923 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 936157012924 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 936157012925 active site 936157012926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 936157012927 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 936157012928 Coenzyme A binding pocket [chemical binding]; other site 936157012929 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 936157012930 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 936157012931 cofactor binding site; other site 936157012932 DNA binding site [nucleotide binding] 936157012933 substrate interaction site [chemical binding]; other site 936157012934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 936157012935 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 936157012936 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 936157012937 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 936157012938 Skp1 family, tetramerisation domain; Region: Skp1_POZ; cl17737 936157012939 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 936157012940 Integrase; Region: Integrase_1; pfam12835 936157012941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157012942 putative substrate translocation pore; other site 936157012943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157012944 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 936157012945 salt bridge; other site 936157012946 non-specific DNA binding site [nucleotide binding]; other site 936157012947 sequence-specific DNA binding site [nucleotide binding]; other site 936157012948 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 936157012949 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 936157012950 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157012951 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 936157012952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157012953 active site 936157012954 motif I; other site 936157012955 motif II; other site 936157012956 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 936157012957 active pocket/dimerization site; other site 936157012958 active site 936157012959 phosphorylation site [posttranslational modification] 936157012960 Integrase; Region: Integrase_1; pfam12835 936157012961 integrase; Provisional; Region: PRK09692 936157012962 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 936157012963 active site 936157012964 Int/Topo IB signature motif; other site 936157012965 putative transcriptional regulator; Provisional; Region: PRK11640 936157012966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 936157012967 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 936157012968 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 936157012969 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 936157012970 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 936157012971 DsbD alpha interface [polypeptide binding]; other site 936157012972 catalytic residues [active] 936157012973 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 936157012974 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 936157012975 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 936157012976 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 936157012977 Aspartase; Region: Aspartase; cd01357 936157012978 active sites [active] 936157012979 tetramer interface [polypeptide binding]; other site 936157012980 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 936157012981 putative transporter; Provisional; Region: PRK11021 936157012982 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 936157012983 oligomerisation interface [polypeptide binding]; other site 936157012984 mobile loop; other site 936157012985 roof hairpin; other site 936157012986 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 936157012987 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 936157012988 ring oligomerisation interface [polypeptide binding]; other site 936157012989 ATP/Mg binding site [chemical binding]; other site 936157012990 stacking interactions; other site 936157012991 hinge regions; other site 936157012992 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 936157012993 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 936157012994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157012995 FeS/SAM binding site; other site 936157012996 elongation factor P; Validated; Region: PRK00529 936157012997 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 936157012998 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 936157012999 RNA binding site [nucleotide binding]; other site 936157013000 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 936157013001 RNA binding site [nucleotide binding]; other site 936157013002 Predicted small secreted protein [Function unknown]; Region: COG5510 936157013003 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 936157013004 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936157013005 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157013006 DNA binding residues [nucleotide binding] 936157013007 dimerization interface [polypeptide binding]; other site 936157013008 multidrug efflux system protein; Provisional; Region: PRK11431 936157013009 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 936157013010 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 936157013011 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 936157013012 Iron-sulfur protein interface; other site 936157013013 proximal quinone binding site [chemical binding]; other site 936157013014 C-subunit interface; other site 936157013015 distal quinone binding site; other site 936157013016 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 936157013017 D-subunit interface [polypeptide binding]; other site 936157013018 Iron-sulfur protein interface; other site 936157013019 proximal quinone binding site [chemical binding]; other site 936157013020 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 936157013021 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 936157013022 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 936157013023 L-aspartate oxidase; Provisional; Region: PRK06175 936157013024 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 936157013025 poxB regulator PoxA; Provisional; Region: PRK09350 936157013026 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 936157013027 motif 1; other site 936157013028 dimer interface [polypeptide binding]; other site 936157013029 active site 936157013030 motif 2; other site 936157013031 motif 3; other site 936157013032 inner membrane transporter YjeM; Provisional; Region: PRK15238 936157013033 putative mechanosensitive channel protein; Provisional; Region: PRK10929 936157013034 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 936157013035 Mechanosensitive ion channel; Region: MS_channel; pfam00924 936157013036 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 936157013037 GTPase RsgA; Reviewed; Region: PRK12288 936157013038 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 936157013039 RNA binding site [nucleotide binding]; other site 936157013040 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 936157013041 GTPase/Zn-binding domain interface [polypeptide binding]; other site 936157013042 GTP/Mg2+ binding site [chemical binding]; other site 936157013043 G4 box; other site 936157013044 G5 box; other site 936157013045 G1 box; other site 936157013046 Switch I region; other site 936157013047 G2 box; other site 936157013048 G3 box; other site 936157013049 Switch II region; other site 936157013050 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 936157013051 catalytic site [active] 936157013052 putative active site [active] 936157013053 putative substrate binding site [chemical binding]; other site 936157013054 dimer interface [polypeptide binding]; other site 936157013055 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 936157013056 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 936157013057 substrate binding pocket [chemical binding]; other site 936157013058 membrane-bound complex binding site; other site 936157013059 hinge residues; other site 936157013060 epoxyqueuosine reductase; Region: TIGR00276 936157013061 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 936157013062 putative carbohydrate kinase; Provisional; Region: PRK10565 936157013063 Uncharacterized conserved protein [Function unknown]; Region: COG0062 936157013064 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 936157013065 putative substrate binding site [chemical binding]; other site 936157013066 putative ATP binding site [chemical binding]; other site 936157013067 ADP-binding protein; Provisional; Region: PRK10646 936157013068 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 936157013069 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 936157013070 active site 936157013071 metal binding site [ion binding]; metal-binding site 936157013072 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 936157013073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157013074 ATP binding site [chemical binding]; other site 936157013075 Mg2+ binding site [ion binding]; other site 936157013076 G-X-G motif; other site 936157013077 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 936157013078 ATP binding site [chemical binding]; other site 936157013079 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 936157013080 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 936157013081 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 936157013082 bacterial Hfq-like; Region: Hfq; cd01716 936157013083 hexamer interface [polypeptide binding]; other site 936157013084 Sm1 motif; other site 936157013085 RNA binding site [nucleotide binding]; other site 936157013086 Sm2 motif; other site 936157013087 GTPase HflX; Provisional; Region: PRK11058 936157013088 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 936157013089 HflX GTPase family; Region: HflX; cd01878 936157013090 G1 box; other site 936157013091 GTP/Mg2+ binding site [chemical binding]; other site 936157013092 Switch I region; other site 936157013093 G2 box; other site 936157013094 G3 box; other site 936157013095 Switch II region; other site 936157013096 G4 box; other site 936157013097 G5 box; other site 936157013098 FtsH protease regulator HflK; Provisional; Region: PRK10930 936157013099 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 936157013100 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 936157013101 FtsH protease regulator HflC; Provisional; Region: PRK11029 936157013102 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 936157013103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 936157013104 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 936157013105 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 936157013106 GDP-binding site [chemical binding]; other site 936157013107 ACT binding site; other site 936157013108 IMP binding site; other site 936157013109 Predicted transcriptional regulator [Transcription]; Region: COG1959 936157013110 transcriptional repressor NsrR; Provisional; Region: PRK11014 936157013111 exoribonuclease R; Provisional; Region: PRK11642 936157013112 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 936157013113 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 936157013114 RNB domain; Region: RNB; pfam00773 936157013115 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 936157013116 RNA binding site [nucleotide binding]; other site 936157013117 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 936157013118 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 936157013119 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 936157013120 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 936157013121 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 936157013122 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 936157013123 Predicted membrane protein [Function unknown]; Region: COG3766 936157013124 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 936157013125 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 936157013126 Predicted integral membrane protein [Function unknown]; Region: COG5463 936157013127 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 936157013128 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 936157013129 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 936157013130 FAD binding site [chemical binding]; other site 936157013131 substrate binding site [chemical binding]; other site 936157013132 catalytic residues [active] 936157013133 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 936157013134 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 936157013135 esterase; Provisional; Region: PRK10566 936157013136 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 936157013137 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 936157013138 transcriptional repressor UlaR; Provisional; Region: PRK13509 936157013139 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 936157013140 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 936157013141 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 936157013142 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 936157013143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 936157013144 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 936157013145 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 936157013146 active site 936157013147 P-loop; other site 936157013148 phosphorylation site [posttranslational modification] 936157013149 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936157013150 active site 936157013151 phosphorylation site [posttranslational modification] 936157013152 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 936157013153 active site 936157013154 dimer interface [polypeptide binding]; other site 936157013155 magnesium binding site [ion binding]; other site 936157013156 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 936157013157 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 936157013158 AP (apurinic/apyrimidinic) site pocket; other site 936157013159 DNA interaction; other site 936157013160 Metal-binding active site; metal-binding site 936157013161 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 936157013162 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 936157013163 intersubunit interface [polypeptide binding]; other site 936157013164 active site 936157013165 Zn2+ binding site [ion binding]; other site 936157013166 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 936157013167 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 936157013168 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 936157013169 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 936157013170 dimer interface [polypeptide binding]; other site 936157013171 ssDNA binding site [nucleotide binding]; other site 936157013172 tetramer (dimer of dimers) interface [polypeptide binding]; other site 936157013173 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 936157013174 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 936157013175 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 936157013176 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 936157013177 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936157013178 EamA-like transporter family; Region: EamA; pfam00892 936157013179 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 936157013180 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 936157013181 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 936157013182 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 936157013183 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 936157013184 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 936157013185 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 936157013186 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 936157013187 Hemerythrin-like domain; Region: Hr-like; cd12108 936157013188 Fe binding site [ion binding]; other site 936157013189 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 936157013190 EamA-like transporter family; Region: EamA; pfam00892 936157013191 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 936157013192 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 936157013193 NADP binding site [chemical binding]; other site 936157013194 Predicted transcriptional regulators [Transcription]; Region: COG1733 936157013195 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 936157013196 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 936157013197 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 936157013198 active site 936157013199 metal binding site [ion binding]; metal-binding site 936157013200 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 936157013201 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 936157013202 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 936157013203 active site 936157013204 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 936157013205 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 936157013206 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 936157013207 Domain of unknown function DUF21; Region: DUF21; pfam01595 936157013208 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 936157013209 Transporter associated domain; Region: CorC_HlyC; smart01091 936157013210 methionine sulfoxide reductase A; Provisional; Region: PRK00058 936157013211 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 936157013212 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 936157013213 Surface antigen; Region: Bac_surface_Ag; pfam01103 936157013214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 936157013215 Family of unknown function (DUF490); Region: DUF490; pfam04357 936157013216 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 936157013217 putative active site pocket [active] 936157013218 dimerization interface [polypeptide binding]; other site 936157013219 putative catalytic residue [active] 936157013220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157013221 D-galactonate transporter; Region: 2A0114; TIGR00893 936157013222 putative substrate translocation pore; other site 936157013223 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 936157013224 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 936157013225 active site 936157013226 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 936157013227 dimer interface [polypeptide binding]; other site 936157013228 substrate binding site [chemical binding]; other site 936157013229 metal binding sites [ion binding]; metal-binding site 936157013230 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 936157013231 AMP binding site [chemical binding]; other site 936157013232 metal binding site [ion binding]; metal-binding site 936157013233 active site 936157013234 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 936157013235 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 936157013236 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 936157013237 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 936157013238 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 936157013239 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 936157013240 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 936157013241 putative active site [active] 936157013242 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 936157013243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157013244 putative substrate translocation pore; other site 936157013245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157013246 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 936157013247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157013248 putative substrate translocation pore; other site 936157013249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157013250 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 936157013251 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 936157013252 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 936157013253 tetrameric interface [polypeptide binding]; other site 936157013254 NAD binding site [chemical binding]; other site 936157013255 catalytic residues [active] 936157013256 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 936157013257 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 936157013258 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157013259 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 936157013260 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936157013261 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936157013262 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936157013263 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 936157013264 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 936157013265 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 936157013266 major facilitator superfamily transporter; Provisional; Region: PRK05122 936157013267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157013268 putative substrate translocation pore; other site 936157013269 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 936157013270 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 936157013271 substrate binding site [chemical binding]; other site 936157013272 ATP binding site [chemical binding]; other site 936157013273 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 936157013274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 936157013275 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 936157013276 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 936157013277 PYR/PP interface [polypeptide binding]; other site 936157013278 dimer interface [polypeptide binding]; other site 936157013279 TPP binding site [chemical binding]; other site 936157013280 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 936157013281 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 936157013282 TPP-binding site; other site 936157013283 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 936157013284 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 936157013285 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 936157013286 polyol permease family; Region: 2A0118; TIGR00897 936157013287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157013288 putative substrate translocation pore; other site 936157013289 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 936157013290 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 936157013291 DNA interaction; other site 936157013292 Metal-binding active site; metal-binding site 936157013293 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 936157013294 hypothetical protein; Provisional; Region: PRK05255 936157013295 peptidase PmbA; Provisional; Region: PRK11040 936157013296 cytochrome b562; Provisional; Region: PRK15058 936157013297 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 936157013298 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 936157013299 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 936157013300 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 936157013301 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 936157013302 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 936157013303 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 936157013304 active site 936157013305 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 936157013306 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 936157013307 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 936157013308 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 936157013309 HTH domain; Region: HTH_11; pfam08279 936157013310 Mga helix-turn-helix domain; Region: Mga; pfam05043 936157013311 PRD domain; Region: PRD; pfam00874 936157013312 PRD domain; Region: PRD; pfam00874 936157013313 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 936157013314 active site 936157013315 P-loop; other site 936157013316 phosphorylation site [posttranslational modification] 936157013317 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 936157013318 active site 936157013319 phosphorylation site [posttranslational modification] 936157013320 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 936157013321 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 936157013322 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 936157013323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157013324 FeS/SAM binding site; other site 936157013325 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 936157013326 ATP cone domain; Region: ATP-cone; pfam03477 936157013327 Class III ribonucleotide reductase; Region: RNR_III; cd01675 936157013328 effector binding site; other site 936157013329 active site 936157013330 Zn binding site [ion binding]; other site 936157013331 glycine loop; other site 936157013332 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 936157013333 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 936157013334 Ca binding site [ion binding]; other site 936157013335 active site 936157013336 catalytic site [active] 936157013337 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 936157013338 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 936157013339 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 936157013340 active site turn [active] 936157013341 phosphorylation site [posttranslational modification] 936157013342 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 936157013343 trehalose repressor; Provisional; Region: treR; PRK09492 936157013344 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157013345 DNA binding site [nucleotide binding] 936157013346 domain linker motif; other site 936157013347 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 936157013348 dimerization interface [polypeptide binding]; other site 936157013349 ligand binding site [chemical binding]; other site 936157013350 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 936157013351 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 936157013352 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 936157013353 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 936157013354 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 936157013355 Soluble P-type ATPase [General function prediction only]; Region: COG4087 936157013356 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 936157013357 Transposase; Region: HTH_Tnp_1; cl17663 936157013358 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 936157013359 homotrimer interaction site [polypeptide binding]; other site 936157013360 putative active site [active] 936157013361 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 936157013362 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 936157013363 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 936157013364 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 936157013365 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 936157013366 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 936157013367 Arginine repressor [Transcription]; Region: ArgR; COG1438 936157013368 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 936157013369 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 936157013370 Predicted membrane protein [Function unknown]; Region: COG1288 936157013371 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 936157013372 ornithine carbamoyltransferase; Validated; Region: PRK02102 936157013373 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 936157013374 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 936157013375 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 936157013376 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 936157013377 putative substrate binding site [chemical binding]; other site 936157013378 nucleotide binding site [chemical binding]; other site 936157013379 nucleotide binding site [chemical binding]; other site 936157013380 homodimer interface [polypeptide binding]; other site 936157013381 arginine deiminase; Provisional; Region: PRK01388 936157013382 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 936157013383 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 936157013384 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 936157013385 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 936157013386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 936157013387 RNase E inhibitor protein; Provisional; Region: PRK11191 936157013388 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 936157013389 active site 936157013390 dinuclear metal binding site [ion binding]; other site 936157013391 dimerization interface [polypeptide binding]; other site 936157013392 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 936157013393 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 936157013394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157013395 Coenzyme A binding pocket [chemical binding]; other site 936157013396 Predicted membrane protein [Function unknown]; Region: COG4269 936157013397 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 936157013398 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 936157013399 HIGH motif; other site 936157013400 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 936157013401 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 936157013402 active site 936157013403 KMSKS motif; other site 936157013404 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 936157013405 tRNA binding surface [nucleotide binding]; other site 936157013406 anticodon binding site; other site 936157013407 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 936157013408 DNA polymerase III subunit chi; Validated; Region: PRK05728 936157013409 multifunctional aminopeptidase A; Provisional; Region: PRK00913 936157013410 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 936157013411 interface (dimer of trimers) [polypeptide binding]; other site 936157013412 Substrate-binding/catalytic site; other site 936157013413 Zn-binding sites [ion binding]; other site 936157013414 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 936157013415 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 936157013416 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 936157013417 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 936157013418 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 936157013419 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 936157013420 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 936157013421 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 936157013422 DNA binding site [nucleotide binding] 936157013423 domain linker motif; other site 936157013424 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 936157013425 putative dimerization interface [polypeptide binding]; other site 936157013426 putative ligand binding site [chemical binding]; other site 936157013427 gluconate transporter; Region: gntP; TIGR00791 936157013428 fructuronate transporter; Provisional; Region: PRK10034; cl15264 936157013429 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 936157013430 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 936157013431 putative NAD(P) binding site [chemical binding]; other site 936157013432 catalytic Zn binding site [ion binding]; other site 936157013433 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 936157013434 ATP-binding site [chemical binding]; other site 936157013435 Gluconate-6-phosphate binding site [chemical binding]; other site 936157013436 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 936157013437 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 936157013438 putative NAD(P) binding site [chemical binding]; other site 936157013439 putative substrate binding site [chemical binding]; other site 936157013440 catalytic Zn binding site [ion binding]; other site 936157013441 structural Zn binding site [ion binding]; other site 936157013442 dimer interface [polypeptide binding]; other site 936157013443 integrase; Provisional; Region: PRK09692 936157013444 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 936157013445 active site 936157013446 Int/Topo IB signature motif; other site 936157013447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 936157013448 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 936157013449 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 936157013450 active site 936157013451 metal binding site [ion binding]; metal-binding site 936157013452 interdomain interaction site; other site 936157013453 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 936157013454 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 936157013455 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 936157013456 portal vertex protein; Provisional; Region: Q; PHA02536 936157013457 Phage portal protein; Region: Phage_portal; pfam04860 936157013458 Winged helix-turn helix; Region: HTH_29; pfam13551 936157013459 Homeodomain-like domain; Region: HTH_23; pfam13384 936157013460 Homeodomain-like domain; Region: HTH_32; pfam13565 936157013461 DDE superfamily endonuclease; Region: DDE_3; pfam13358 936157013462 Methyltransferase domain; Region: Methyltransf_27; pfam13708 936157013463 Predicted transcriptional regulator [Transcription]; Region: COG3905 936157013464 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 936157013465 CcdB protein; Region: CcdB; pfam01845 936157013466 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 936157013467 Integrase core domain; Region: rve; pfam00665 936157013468 Integrase core domain; Region: rve_3; pfam13683 936157013469 HTH-like domain; Region: HTH_21; pfam13276 936157013470 putative uncharacterized protein yjiT 936157013471 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 936157013472 HNH endonuclease; Region: HNH_2; pfam13391 936157013473 hypothetical protein; Provisional; Region: PRK12378 936157013474 Methyltransferase domain; Region: Methyltransf_23; pfam13489 936157013475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157013476 S-adenosylmethionine binding site [chemical binding]; other site 936157013477 Methyltransferase domain; Region: Methyltransf_31; pfam13847 936157013478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157013479 S-adenosylmethionine binding site [chemical binding]; other site 936157013480 hypothetical protein; Provisional; Region: PRK13687 936157013481 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 936157013482 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 936157013483 Predicted membrane protein [Function unknown]; Region: COG2733 936157013484 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 936157013485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157013486 putative substrate translocation pore; other site 936157013487 putative transposase; Provisional; Region: PRK09857 936157013488 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 936157013489 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 936157013490 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 936157013491 NAD(P) binding site [chemical binding]; other site 936157013492 catalytic residues [active] 936157013493 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 936157013494 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 936157013495 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 936157013496 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 936157013497 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 936157013498 HsdM N-terminal domain; Region: HsdM_N; pfam12161 936157013499 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 936157013500 Methyltransferase domain; Region: Methyltransf_26; pfam13659 936157013501 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 936157013502 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 936157013503 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 936157013504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 936157013505 ATP binding site [chemical binding]; other site 936157013506 putative Mg++ binding site [ion binding]; other site 936157013507 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 936157013508 Mrr N-terminal domain; Region: Mrr_N; pfam14338 936157013509 Restriction endonuclease; Region: Mrr_cat; pfam04471 936157013510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 936157013511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 936157013512 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 936157013513 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 936157013514 P-loop, Walker A motif; other site 936157013515 Base recognition motif; other site 936157013516 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 936157013517 Uncharacterized small protein [Function unknown]; Region: COG2879 936157013518 carbon starvation protein A; Provisional; Region: PRK15015 936157013519 Carbon starvation protein CstA; Region: CstA; pfam02554 936157013520 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 936157013521 methyl-accepting protein IV; Provisional; Region: PRK09793 936157013522 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 936157013523 dimer interface [polypeptide binding]; other site 936157013524 ligand binding site [chemical binding]; other site 936157013525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 936157013526 dimerization interface [polypeptide binding]; other site 936157013527 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 936157013528 dimer interface [polypeptide binding]; other site 936157013529 putative CheW interface [polypeptide binding]; other site 936157013530 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 936157013531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157013532 Walker A motif; other site 936157013533 ATP binding site [chemical binding]; other site 936157013534 Walker B motif; other site 936157013535 arginine finger; other site 936157013536 Transcriptional antiterminator [Transcription]; Region: COG3933 936157013537 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 936157013538 active pocket/dimerization site; other site 936157013539 active site 936157013540 phosphorylation site [posttranslational modification] 936157013541 PRD domain; Region: PRD; pfam00874 936157013542 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 936157013543 active pocket/dimerization site; other site 936157013544 active site 936157013545 phosphorylation site [posttranslational modification] 936157013546 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 936157013547 active site 936157013548 phosphorylation site [posttranslational modification] 936157013549 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 936157013550 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 936157013551 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 936157013552 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 936157013553 dimer interface [polypeptide binding]; other site 936157013554 active site 936157013555 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 936157013556 dimer interface [polypeptide binding]; other site 936157013557 active site 936157013558 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 936157013559 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 936157013560 putative active site [active] 936157013561 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 936157013562 phosphoglycerol transferase I; Provisional; Region: PRK03776 936157013563 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 936157013564 hypothetical protein; Provisional; Region: PRK11667 936157013565 DNA replication protein DnaC; Validated; Region: PRK07952 936157013566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 936157013567 Walker A motif; other site 936157013568 ATP binding site [chemical binding]; other site 936157013569 Walker B motif; other site 936157013570 primosomal protein DnaI; Provisional; Region: PRK02854 936157013571 hypothetical protein; Provisional; Region: PRK09917 936157013572 Uncharacterized conserved protein [Function unknown]; Region: COG2966 936157013573 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 936157013574 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 936157013575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157013576 DNA binding residues [nucleotide binding] 936157013577 dimerization interface [polypeptide binding]; other site 936157013578 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 936157013579 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 936157013580 DNA binding residues [nucleotide binding] 936157013581 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 936157013582 putative deacylase active site [active] 936157013583 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 936157013584 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 936157013585 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 936157013586 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 936157013587 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 936157013588 metal binding site [ion binding]; metal-binding site 936157013589 active site 936157013590 I-site; other site 936157013591 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 936157013592 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 936157013593 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 936157013594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 936157013595 S-adenosylmethionine binding site [chemical binding]; other site 936157013596 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 936157013597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 936157013598 Coenzyme A binding pocket [chemical binding]; other site 936157013599 dUMP phosphatase; Provisional; Region: PRK09449 936157013600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157013601 motif II; other site 936157013602 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 936157013603 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 936157013604 G1 box; other site 936157013605 putative GEF interaction site [polypeptide binding]; other site 936157013606 GTP/Mg2+ binding site [chemical binding]; other site 936157013607 Switch I region; other site 936157013608 G2 box; other site 936157013609 G3 box; other site 936157013610 Switch II region; other site 936157013611 G4 box; other site 936157013612 G5 box; other site 936157013613 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 936157013614 periplasmic protein; Provisional; Region: PRK10568 936157013615 BON domain; Region: BON; pfam04972 936157013616 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 936157013617 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 936157013618 active site 936157013619 nucleophile elbow; other site 936157013620 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 936157013621 active site 936157013622 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 936157013623 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157013624 FeS/SAM binding site; other site 936157013625 hypothetical protein; Provisional; Region: PRK10977 936157013626 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 936157013627 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 936157013628 intersubunit interface [polypeptide binding]; other site 936157013629 active site 936157013630 catalytic residue [active] 936157013631 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 936157013632 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 936157013633 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 936157013634 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 936157013635 phosphopentomutase; Provisional; Region: PRK05362 936157013636 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 936157013637 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 936157013638 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 936157013639 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 936157013640 HipA-like C-terminal domain; Region: HipA_C; pfam07804 936157013641 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 936157013642 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 936157013643 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 936157013644 hypothetical protein; Provisional; Region: PRK11246 936157013645 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 936157013646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 936157013647 motif II; other site 936157013648 DNA repair protein RadA; Region: sms; TIGR00416 936157013649 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 936157013650 Walker A motif/ATP binding site; other site 936157013651 ATP binding site [chemical binding]; other site 936157013652 Walker B motif; other site 936157013653 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 936157013654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 936157013655 non-specific DNA binding site [nucleotide binding]; other site 936157013656 salt bridge; other site 936157013657 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 936157013658 sequence-specific DNA binding site [nucleotide binding]; other site 936157013659 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 936157013660 active site 936157013661 (T/H)XGH motif; other site 936157013662 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 936157013663 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 936157013664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936157013665 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936157013666 ABC transporter; Region: ABC_tran_2; pfam12848 936157013667 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 936157013668 lytic murein transglycosylase; Provisional; Region: PRK11619 936157013669 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 936157013670 N-acetyl-D-glucosamine binding site [chemical binding]; other site 936157013671 catalytic residue [active] 936157013672 Trp operon repressor; Provisional; Region: PRK01381 936157013673 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 936157013674 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 936157013675 catalytic core [active] 936157013676 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 936157013677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 936157013678 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 936157013679 hypothetical protein; Provisional; Region: PRK10756 936157013680 CreA protein; Region: CreA; pfam05981 936157013681 DNA-binding response regulator CreB; Provisional; Region: PRK11083 936157013682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157013683 active site 936157013684 phosphorylation site [posttranslational modification] 936157013685 intermolecular recognition site; other site 936157013686 dimerization interface [polypeptide binding]; other site 936157013687 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157013688 DNA binding site [nucleotide binding] 936157013689 sensory histidine kinase CreC; Provisional; Region: PRK11100 936157013690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 936157013691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 936157013692 dimer interface [polypeptide binding]; other site 936157013693 phosphorylation site [posttranslational modification] 936157013694 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 936157013695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157013696 ATP binding site [chemical binding]; other site 936157013697 Mg2+ binding site [ion binding]; other site 936157013698 G-X-G motif; other site 936157013699 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 936157013700 putative major fimbrial protein SthE; Provisional; Region: PRK15292 936157013701 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 936157013702 putative fimbrial protein SthD; Provisional; Region: PRK15293 936157013703 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 936157013704 PapC N-terminal domain; Region: PapC_N; pfam13954 936157013705 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 936157013706 PapC C-terminal domain; Region: PapC_C; pfam13953 936157013707 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 936157013708 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 936157013709 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 936157013710 putative fimbrial protein SthA; Provisional; Region: PRK15296 936157013711 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 936157013712 Helix-turn-helix domain; Region: HTH_36; pfam13730 936157013713 two-component response regulator; Provisional; Region: PRK11173 936157013714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157013715 active site 936157013716 phosphorylation site [posttranslational modification] 936157013717 intermolecular recognition site; other site 936157013718 dimerization interface [polypeptide binding]; other site 936157013719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 936157013720 DNA binding site [nucleotide binding] 936157013721 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 936157013722 putative RNA methyltransferase; Provisional; Region: PRK10433 936157013723 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 936157013724 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 936157013725 putative catalytic residues [active] 936157013726 putative nucleotide binding site [chemical binding]; other site 936157013727 putative aspartate binding site [chemical binding]; other site 936157013728 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 936157013729 dimer interface [polypeptide binding]; other site 936157013730 putative threonine allosteric regulatory site; other site 936157013731 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 936157013732 putative threonine allosteric regulatory site; other site 936157013733 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 936157013734 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 936157013735 homoserine kinase; Provisional; Region: PRK01212 936157013736 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 936157013737 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 936157013738 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 936157013739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 936157013740 catalytic residue [active] 936157013741 hypothetical protein; Validated; Region: PRK02101 936157013742 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 936157013743 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 936157013744 transaldolase-like protein; Provisional; Region: PTZ00411 936157013745 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 936157013746 active site 936157013747 dimer interface [polypeptide binding]; other site 936157013748 catalytic residue [active] 936157013749 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 936157013750 MPT binding site; other site 936157013751 trimer interface [polypeptide binding]; other site 936157013752 hypothetical protein; Provisional; Region: PRK10659 936157013753 hypothetical protein; Provisional; Region: PRK10236 936157013754 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 936157013755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 936157013756 Protein of unknown function (DUF2541); Region: DUF2541; cl08090 936157013757 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 936157013758 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 936157013759 nucleotide binding site [chemical binding]; other site 936157013760 chaperone protein DnaJ; Provisional; Region: PRK10767 936157013761 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 936157013762 HSP70 interaction site [polypeptide binding]; other site 936157013763 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 936157013764 substrate binding site [polypeptide binding]; other site 936157013765 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 936157013766 Zn binding sites [ion binding]; other site 936157013767 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 936157013768 dimer interface [polypeptide binding]; other site 936157013769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157013770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157013771 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 936157013772 substrate binding pocket [chemical binding]; other site 936157013773 dimerization interface [polypeptide binding]; other site 936157013774 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 936157013775 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 936157013776 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 936157013777 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 936157013778 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 936157013779 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 936157013780 active site 936157013781 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 936157013782 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 936157013783 aromatic chitin/cellulose binding site residues [chemical binding]; other site 936157013784 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 936157013785 Helix-turn-helix domain; Region: HTH_36; pfam13730 936157013786 fimbrial protein BcfA; Provisional; Region: PRK15187 936157013787 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 936157013788 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 936157013789 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 936157013790 outer membrane usher protein; Provisional; Region: PRK15193 936157013791 PapC N-terminal domain; Region: PapC_N; pfam13954 936157013792 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 936157013793 PapC C-terminal domain; Region: PapC_C; pfam13953 936157013794 fimbrial protein BcfD; Provisional; Region: PRK15189 936157013795 fimbrial protein BcfE; Provisional; Region: PRK15190 936157013796 fimbrial protein BcfF; Provisional; Region: PRK15191 936157013797 fimbrial chaperone BcfG; Provisional; Region: PRK15192 936157013798 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 936157013799 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 936157013800 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 936157013801 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 936157013802 catalytic residues [active] 936157013803 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 936157013804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 936157013805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157013806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 936157013807 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 936157013808 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 936157013809 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 936157013810 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 936157013811 active site 936157013812 metal binding site [ion binding]; metal-binding site 936157013813 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 936157013814 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 936157013815 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 936157013816 Sulfatase; Region: Sulfatase; pfam00884 936157013817 Radical SAM superfamily; Region: Radical_SAM; pfam04055 936157013818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 936157013819 FeS/SAM binding site; other site 936157013820 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 936157013821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 936157013822 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 936157013823 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 936157013824 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 936157013825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 936157013826 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 936157013827 putative dimerization interface [polypeptide binding]; other site 936157013828 putative alpha-glucosidase; Provisional; Region: PRK10658 936157013829 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 936157013830 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 936157013831 putative active site [active] 936157013832 putative catalytic site [active] 936157013833 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 936157013834 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 936157013835 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 936157013836 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 936157013837 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 936157013838 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 936157013839 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 936157013840 active site 936157013841 Riboflavin kinase; Region: Flavokinase; smart00904 936157013842 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 936157013843 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 936157013844 active site 936157013845 HIGH motif; other site 936157013846 nucleotide binding site [chemical binding]; other site 936157013847 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 936157013848 active site 936157013849 KMSKS motif; other site 936157013850 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 936157013851 tRNA binding surface [nucleotide binding]; other site 936157013852 anticodon binding site; other site 936157013853 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 936157013854 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 936157013855 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 936157013856 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 936157013857 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 936157013858 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 936157013859 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 936157013860 active site 936157013861 tetramer interface [polypeptide binding]; other site 936157013862 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 936157013863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 936157013864 active site 936157013865 phosphorylation site [posttranslational modification] 936157013866 intermolecular recognition site; other site 936157013867 dimerization interface [polypeptide binding]; other site 936157013868 Transcriptional regulator; Region: CitT; pfam12431 936157013869 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 936157013870 PAS domain; Region: PAS; smart00091 936157013871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 936157013872 ATP binding site [chemical binding]; other site 936157013873 Mg2+ binding site [ion binding]; other site 936157013874 G-X-G motif; other site 936157013875 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 936157013876 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 936157013877 carboxyltransferase (CT) interaction site; other site 936157013878 biotinylation site [posttranslational modification]; other site 936157013879 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936157013880 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936157013881 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936157013882 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 936157013883 Transposase IS200 like; Region: Y1_Tnp; pfam01797 936157013884 Transposase, Mutator family; Region: Transposase_mut; pfam00872 936157013885 MULE transposase domain; Region: MULE; pfam10551 936157013886 Sensor protein rcsC; Capsular synthesis regulator component C;, RcsC Alpha-Beta-Loop (ABL), phoR_proteo: phosphate regulon sensor kinase PhoR, Signal transduction histidine kinase, core 936157013887 Phage-related protein, tail component [Function unknown]; Region: COG4723 936157013888 Host specificity protein J;, Fibronectin, type III 936157013889 Minor tail protein Z; GpZ;, Prophage minor tail protein Z (GPZ), Prophage minor tail Z 936157013890 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 936157013891 DNA packaging protein FI; Region: Packaging_FI; pfam14000 936157013892 replication protein; Provisional; Region: PRK13750 936157013893 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 936157013894 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 936157013895 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 936157013896 dimer interface [polypeptide binding]; other site 936157013897 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 936157013898 active site 936157013899 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 936157013900 catalytic residues [active] 936157013901 substrate binding site [chemical binding]; other site 936157013902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 936157013903 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 936157013904 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 936157013905 metal binding triad [ion binding]; metal-binding site 936157013906 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 936157013907 Cytotoxic; Region: Cytotoxic; pfam09000 936157013908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 936157013909 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 936157013910 putative transposase OrfB; Reviewed; Region: PHA02517 936157013911 HTH-like domain; Region: HTH_21; pfam13276 936157013912 Integrase core domain; Region: rve; pfam00665 936157013913 Integrase core domain; Region: rve_2; pfam13333 936157013914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 936157013915 Transposase; Region: HTH_Tnp_1; pfam01527 936157013916 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 936157013917 HTH-like domain; Region: HTH_21; pfam13276 936157013918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 936157013919 Integrase core domain; Region: rve; pfam00665 936157013920 Integrase core domain; Region: rve_3; pfam13683 936157013921 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 936157013922 DNA-binding interface [nucleotide binding]; DNA binding site 936157013923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 936157013924 Major Facilitator Superfamily; Region: MFS_1; pfam07690 936157013925 putative substrate translocation pore; other site 936157013926 Condensation domain; Region: Condensation; pfam00668 936157013927 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936157013928 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936157013929 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936157013930 acyl-activating enzyme (AAE) consensus motif; other site 936157013931 AMP binding site [chemical binding]; other site 936157013932 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936157013933 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 936157013934 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 936157013935 active site 936157013936 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 936157013937 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 936157013938 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 936157013939 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 936157013940 putative NADP binding site [chemical binding]; other site 936157013941 active site 936157013942 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936157013943 Condensation domain; Region: Condensation; pfam00668 936157013944 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936157013945 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936157013946 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936157013947 acyl-activating enzyme (AAE) consensus motif; other site 936157013948 AMP binding site [chemical binding]; other site 936157013949 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936157013950 Condensation domain; Region: Condensation; pfam00668 936157013951 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 936157013952 Thioesterase domain; Region: Thioesterase; pfam00975 936157013953 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936157013954 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 936157013955 acyl-activating enzyme (AAE) consensus motif; other site 936157013956 AMP binding site [chemical binding]; other site 936157013957 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936157013958 Condensation domain; Region: Condensation; pfam00668 936157013959 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 936157013960 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 936157013961 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936157013962 acyl-activating enzyme (AAE) consensus motif; other site 936157013963 AMP binding site [chemical binding]; other site 936157013964 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936157013965 Condensation domain; Region: Condensation; pfam00668 936157013966 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 936157013967 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 936157013968 acyl-activating enzyme (AAE) consensus motif; other site 936157013969 AMP binding site [chemical binding]; other site 936157013970 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 936157013971 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 936157013972 Transposase; Region: HTH_Tnp_1; cl17663 936157013973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 936157013974 IS2 transposase TnpB; Reviewed; Region: PRK09409 936157013975 HTH-like domain; Region: HTH_21; pfam13276 936157013976 Integrase core domain; Region: rve; pfam00665 936157013977 Integrase core domain; Region: rve_3; pfam13683 936157013978 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 936157013979 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 936157013980 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 936157013981 active site 936157013982 catalytic residues [active] 936157013983 DNA binding site [nucleotide binding] 936157013984 Int/Topo IB signature motif; other site 936157013985 Uncharacterized conserved protein [Function unknown]; Region: COG5464 936157013986 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 936157013987 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 936157013988 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 936157013989 P-loop; other site 936157013990 Magnesium ion binding site [ion binding]; other site 936157013991 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 936157013992 Magnesium ion binding site [ion binding]; other site 936157013993 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 936157013994 ParB-like nuclease domain; Region: ParBc; pfam02195 936157013995 ParB family; Region: ParB; pfam08775 936157013996 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 936157013997 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 936157013998 active site 936157013999 DNA binding site [nucleotide binding] 936157014000 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 936157014001 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 936157014002 Catalytic site [active] 936157014003 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 936157014004 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 936157014005 DNA methylase; Region: N6_N4_Mtase; cl17433 936157014006 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 936157014007 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 936157014008 Antirestriction protein (ArdA); Region: ArdA; cl01953 936157014009 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 936157014010 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 936157014011 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 936157014012 dimer interface [polypeptide binding]; other site 936157014013 ssDNA binding site [nucleotide binding]; other site 936157014014 tetramer (dimer of dimers) interface [polypeptide binding]; other site 936157014015 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 936157014016 ParB-like nuclease domain; Region: ParBc; pfam02195 936157014017 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 936157014018 Plasmid SOS inhibition protein (PsiB); Region: PsiB; pfam06290 936157014019 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 936157014020 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 936157014021 FMN binding site [chemical binding]; other site 936157014022 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 936157014023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 936157014024 Probable transposase; Region: OrfB_IS605; pfam01385 936157014025 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 936157014026 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 936157014027 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 936157014028 Antirestriction protein; Region: Antirestrict; pfam03230 936157014029 Transposase IS200 like; Region: Y1_Tnp; pfam01797 936157014030 Transposase, Mutator family; Region: Transposase_mut; pfam00872 936157014031 MULE transposase domain; Region: MULE; pfam10551 936157014032 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 936157014033 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 936157014034 conjugal transfer protein TraD; Provisional; Region: PRK13700 936157014035 F sex factor protein N terminal; Region: TraD_N; pfam12615 936157014036 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 936157014037 Walker A motif; other site 936157014038 ATP binding site [chemical binding]; other site 936157014039 Walker B motif; other site 936157014040 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 936157014041 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 936157014042 AAA domain; Region: AAA_30; pfam13604 936157014043 Family description; Region: UvrD_C_2; pfam13538 936157014044 DNA helicase TraI; Region: TraI; pfam07057 936157014045 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 936157014046 TraX protein; Region: TraX; cl05434 936157014047 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 936157014048 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 936157014049 putative active site [active] 936157014050 catalytic site [active] 936157014051 replication protein; Provisional; Region: PRK13702