-- dump date 20140620_061824 -- class Genbank::misc_feature -- table misc_feature_note -- id note 446469000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 446469000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469000003 Walker A motif; other site 446469000004 ATP binding site [chemical binding]; other site 446469000005 Walker B motif; other site 446469000006 arginine finger; other site 446469000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 446469000008 DnaA box-binding interface [nucleotide binding]; other site 446469000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 446469000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 446469000011 putative DNA binding surface [nucleotide binding]; other site 446469000012 dimer interface [polypeptide binding]; other site 446469000013 beta-clamp/clamp loader binding surface; other site 446469000014 beta-clamp/translesion DNA polymerase binding surface; other site 446469000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446469000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 446469000017 recombination protein F; Reviewed; Region: recF; PRK00064 446469000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 446469000019 Walker A/P-loop; other site 446469000020 ATP binding site [chemical binding]; other site 446469000021 Q-loop/lid; other site 446469000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469000023 ABC transporter signature motif; other site 446469000024 Walker B; other site 446469000025 D-loop; other site 446469000026 H-loop/switch region; other site 446469000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 446469000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 446469000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 446469000030 anchoring element; other site 446469000031 dimer interface [polypeptide binding]; other site 446469000032 ATP binding site [chemical binding]; other site 446469000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 446469000034 active site 446469000035 putative metal-binding site [ion binding]; other site 446469000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446469000037 DNA gyrase subunit A; Validated; Region: PRK05560 446469000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 446469000039 CAP-like domain; other site 446469000040 active site 446469000041 primary dimer interface [polypeptide binding]; other site 446469000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446469000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446469000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446469000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446469000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446469000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446469000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 446469000049 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 446469000050 active site 446469000051 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 446469000052 Rhomboid family; Region: Rhomboid; pfam01694 446469000053 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 446469000054 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 446469000055 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 446469000056 Glutamine amidotransferase class-I; Region: GATase; pfam00117 446469000057 glutamine binding [chemical binding]; other site 446469000058 catalytic triad [active] 446469000059 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446469000060 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446469000061 active site 446469000062 ATP binding site [chemical binding]; other site 446469000063 substrate binding site [chemical binding]; other site 446469000064 activation loop (A-loop); other site 446469000065 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446469000066 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446469000067 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446469000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446469000069 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446469000070 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446469000071 active site 446469000072 ATP binding site [chemical binding]; other site 446469000073 substrate binding site [chemical binding]; other site 446469000074 activation loop (A-loop); other site 446469000075 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 446469000076 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446469000077 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 446469000078 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446469000079 active site 446469000080 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446469000081 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446469000082 phosphopeptide binding site; other site 446469000083 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 446469000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446469000085 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446469000086 phosphopeptide binding site; other site 446469000087 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 446469000088 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 446469000089 dimer interface [polypeptide binding]; other site 446469000090 active site 446469000091 metal binding site [ion binding]; metal-binding site 446469000092 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469000093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469000094 putative Zn2+ binding site [ion binding]; other site 446469000095 putative DNA binding site [nucleotide binding]; other site 446469000096 dimerization interface [polypeptide binding]; other site 446469000097 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 446469000098 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 446469000099 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446469000100 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 446469000101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446469000102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446469000103 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446469000104 dimerization interface [polypeptide binding]; other site 446469000105 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446469000106 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446469000107 active site 446469000108 PQQ-like domain; Region: PQQ_2; pfam13360 446469000109 PQQ-like domain; Region: PQQ_2; pfam13360 446469000110 Uncharacterized conserved protein [Function unknown]; Region: COG4850 446469000111 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 446469000112 aspartate aminotransferase; Provisional; Region: PRK05764 446469000113 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446469000114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469000115 homodimer interface [polypeptide binding]; other site 446469000116 catalytic residue [active] 446469000117 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446469000118 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446469000119 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 446469000120 putative active site [active] 446469000121 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 446469000122 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446469000123 tetramer interface [polypeptide binding]; other site 446469000124 active site 446469000125 Mg2+/Mn2+ binding site [ion binding]; other site 446469000126 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 446469000127 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 446469000128 AlkA N-terminal domain; Region: AlkA_N; pfam06029 446469000129 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446469000130 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469000131 MarR family; Region: MarR; pfam01047 446469000132 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 446469000133 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 446469000134 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446469000135 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 446469000136 NAD binding site [chemical binding]; other site 446469000137 substrate binding site [chemical binding]; other site 446469000138 catalytic Zn binding site [ion binding]; other site 446469000139 structural Zn binding site [ion binding]; other site 446469000140 glycine dehydrogenase; Provisional; Region: PRK05367 446469000141 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446469000142 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446469000143 catalytic residue [active] 446469000144 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446469000145 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446469000146 catalytic residue [active] 446469000147 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 446469000148 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446469000149 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 446469000150 lipoyl attachment site [posttranslational modification]; other site 446469000151 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 446469000152 active site 446469000153 8-oxo-dGMP binding site [chemical binding]; other site 446469000154 nudix motif; other site 446469000155 metal binding site [ion binding]; metal-binding site 446469000156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469000157 NAD(P) binding site [chemical binding]; other site 446469000158 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446469000159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469000160 active site 446469000161 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446469000162 Predicted transcriptional regulators [Transcription]; Region: COG1695 446469000163 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446469000164 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 446469000165 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446469000166 DNA interaction; other site 446469000167 Metal-binding active site; metal-binding site 446469000168 AP (apurinic/apyrimidinic) site pocket; other site 446469000169 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 446469000170 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 446469000171 THF binding site; other site 446469000172 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 446469000173 substrate binding site [chemical binding]; other site 446469000174 THF binding site; other site 446469000175 zinc-binding site [ion binding]; other site 446469000176 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 446469000177 FAD binding site [chemical binding]; other site 446469000178 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446469000179 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446469000180 active site 446469000181 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 446469000182 Bacterial PH domain; Region: DUF304; pfam03703 446469000183 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446469000184 putative active site [active] 446469000185 catalytic site [active] 446469000186 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469000187 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 446469000188 DNA binding residues [nucleotide binding] 446469000189 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 446469000190 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446469000191 active site 446469000192 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 446469000193 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 446469000194 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 446469000195 active site 446469000196 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 446469000197 putative switch regulator; other site 446469000198 non-specific DNA interactions [nucleotide binding]; other site 446469000199 DNA binding site [nucleotide binding] 446469000200 sequence specific DNA binding site [nucleotide binding]; other site 446469000201 putative cAMP binding site [chemical binding]; other site 446469000202 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446469000203 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469000204 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 446469000205 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 446469000206 active site 446469000207 trimer interface [polypeptide binding]; other site 446469000208 allosteric site; other site 446469000209 active site lid [active] 446469000210 hexamer (dimer of trimers) interface [polypeptide binding]; other site 446469000211 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469000212 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446469000213 nucleotide binding site [chemical binding]; other site 446469000214 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 446469000215 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 446469000216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469000217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469000218 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 446469000219 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469000220 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 446469000221 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 446469000222 Predicted membrane protein [Function unknown]; Region: COG2364 446469000223 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 446469000224 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446469000225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469000226 S-adenosylmethionine binding site [chemical binding]; other site 446469000227 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446469000228 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446469000229 active site 446469000230 catalytic site [active] 446469000231 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 446469000232 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469000233 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446469000234 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469000235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000236 dimer interface [polypeptide binding]; other site 446469000237 conserved gate region; other site 446469000238 ABC-ATPase subunit interface; other site 446469000239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000240 dimer interface [polypeptide binding]; other site 446469000241 conserved gate region; other site 446469000242 putative PBP binding loops; other site 446469000243 ABC-ATPase subunit interface; other site 446469000244 Phosphate transporter family; Region: PHO4; cl00396 446469000245 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 446469000246 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 446469000247 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 446469000248 active site 446469000249 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446469000250 DNA binding site [nucleotide binding] 446469000251 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 446469000252 homodimer interface [polypeptide binding]; other site 446469000253 active site 446469000254 SAM binding site [chemical binding]; other site 446469000255 nitrite reductase subunit NirD; Provisional; Region: PRK14989 446469000256 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446469000257 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446469000258 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 446469000259 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 446469000260 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 446469000261 putative active site [active] 446469000262 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 446469000263 active site 446469000264 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446469000265 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 446469000266 active site 446469000267 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446469000268 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446469000269 Coenzyme A binding pocket [chemical binding]; other site 446469000270 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 446469000271 active site 446469000272 substrate binding site [chemical binding]; other site 446469000273 trimer interface [polypeptide binding]; other site 446469000274 CoA binding site [chemical binding]; other site 446469000275 Ferredoxin [Energy production and conversion]; Region: COG1146 446469000276 4Fe-4S binding domain; Region: Fer4; pfam00037 446469000277 RibD C-terminal domain; Region: RibD_C; cl17279 446469000278 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446469000279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469000280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469000281 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469000282 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469000283 WHG domain; Region: WHG; pfam13305 446469000284 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446469000285 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446469000286 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446469000287 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469000288 ATP binding site [chemical binding]; other site 446469000289 putative Mg++ binding site [ion binding]; other site 446469000290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469000291 nucleotide binding region [chemical binding]; other site 446469000292 ATP-binding site [chemical binding]; other site 446469000293 Helicase associated domain (HA2); Region: HA2; pfam04408 446469000294 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 446469000295 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 446469000296 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 446469000297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469000298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469000299 DNA binding site [nucleotide binding] 446469000300 domain linker motif; other site 446469000301 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446469000302 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446469000303 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446469000304 Walker A/P-loop; other site 446469000305 ATP binding site [chemical binding]; other site 446469000306 Q-loop/lid; other site 446469000307 ABC transporter signature motif; other site 446469000308 Walker B; other site 446469000309 D-loop; other site 446469000310 H-loop/switch region; other site 446469000311 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446469000312 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446469000313 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446469000314 TM-ABC transporter signature motif; other site 446469000315 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 446469000316 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 446469000317 ligand binding site [chemical binding]; other site 446469000318 dimerization interface [polypeptide binding]; other site 446469000319 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446469000320 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446469000321 substrate binding site [chemical binding]; other site 446469000322 ATP binding site [chemical binding]; other site 446469000323 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 446469000324 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446469000325 RHS Repeat; Region: RHS_repeat; pfam05593 446469000326 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 446469000327 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 446469000328 putative deacylase active site [active] 446469000329 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 446469000330 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446469000331 G1 box; other site 446469000332 GTP/Mg2+ binding site [chemical binding]; other site 446469000333 G2 box; other site 446469000334 Switch I region; other site 446469000335 G3 box; other site 446469000336 Switch II region; other site 446469000337 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446469000338 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469000339 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469000340 ABC transporter; Region: ABC_tran_2; pfam12848 446469000341 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469000342 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446469000343 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 446469000344 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446469000345 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 446469000346 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446469000347 dimer interface [polypeptide binding]; other site 446469000348 ADP-ribose binding site [chemical binding]; other site 446469000349 active site 446469000350 nudix motif; other site 446469000351 metal binding site [ion binding]; metal-binding site 446469000352 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 446469000353 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 446469000354 RNAase interaction site [polypeptide binding]; other site 446469000355 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446469000356 anti sigma factor interaction site; other site 446469000357 regulatory phosphorylation site [posttranslational modification]; other site 446469000358 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 446469000359 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446469000360 active site 446469000361 metal binding site [ion binding]; metal-binding site 446469000362 DNA binding site [nucleotide binding] 446469000363 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 446469000364 AAA domain; Region: AAA_23; pfam13476 446469000365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469000366 Walker A/P-loop; other site 446469000367 ATP binding site [chemical binding]; other site 446469000368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469000369 Q-loop/lid; other site 446469000370 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 446469000371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469000372 ABC transporter signature motif; other site 446469000373 Walker B; other site 446469000374 D-loop; other site 446469000375 H-loop/switch region; other site 446469000376 glycogen branching enzyme; Provisional; Region: PRK14705 446469000377 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 446469000378 Na2 binding site [ion binding]; other site 446469000379 putative substrate binding site 1 [chemical binding]; other site 446469000380 Na binding site 1 [ion binding]; other site 446469000381 putative substrate binding site 2 [chemical binding]; other site 446469000382 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446469000383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469000384 S-adenosylmethionine binding site [chemical binding]; other site 446469000385 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 446469000386 diiron binding motif [ion binding]; other site 446469000387 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 446469000388 ferredoxin-NADP+ reductase; Region: PLN02852 446469000389 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446469000390 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 446469000391 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 446469000392 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 446469000393 DivIVA domain; Region: DivI1A_domain; TIGR03544 446469000394 DivIVA domain; Region: DivI1A_domain; TIGR03544 446469000395 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 446469000396 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 446469000397 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 446469000398 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 446469000399 Predicted membrane protein [Function unknown]; Region: COG4270 446469000400 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446469000401 Phosphotransferase enzyme family; Region: APH; pfam01636 446469000402 active site 446469000403 substrate binding site [chemical binding]; other site 446469000404 ATP binding site [chemical binding]; other site 446469000405 pyruvate dehydrogenase; Provisional; Region: PRK06546 446469000406 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 446469000407 PYR/PP interface [polypeptide binding]; other site 446469000408 tetramer interface [polypeptide binding]; other site 446469000409 dimer interface [polypeptide binding]; other site 446469000410 TPP binding site [chemical binding]; other site 446469000411 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446469000412 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 446469000413 TPP-binding site [chemical binding]; other site 446469000414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446469000415 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 446469000416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469000417 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469000418 putative substrate translocation pore; other site 446469000419 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446469000420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469000421 Response regulator receiver domain; Region: Response_reg; pfam00072 446469000422 active site 446469000423 phosphorylation site [posttranslational modification] 446469000424 intermolecular recognition site; other site 446469000425 dimerization interface [polypeptide binding]; other site 446469000426 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469000427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469000428 DNA binding site [nucleotide binding] 446469000429 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446469000430 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 446469000431 DXD motif; other site 446469000432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469000433 Coenzyme A binding pocket [chemical binding]; other site 446469000434 phosphoglucomutase; Validated; Region: PRK07564 446469000435 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 446469000436 active site 446469000437 substrate binding site [chemical binding]; other site 446469000438 metal binding site [ion binding]; metal-binding site 446469000439 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 446469000440 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446469000441 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06589 446469000442 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446469000443 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446469000444 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 446469000445 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 446469000446 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 446469000447 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446469000448 active site 446469000449 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 446469000450 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 446469000451 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446469000452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469000453 Walker A/P-loop; other site 446469000454 ATP binding site [chemical binding]; other site 446469000455 Q-loop/lid; other site 446469000456 ABC transporter signature motif; other site 446469000457 Walker B; other site 446469000458 D-loop; other site 446469000459 H-loop/switch region; other site 446469000460 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 446469000461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469000462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469000463 active site 446469000464 phosphorylation site [posttranslational modification] 446469000465 intermolecular recognition site; other site 446469000466 dimerization interface [polypeptide binding]; other site 446469000467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469000468 DNA binding site [nucleotide binding] 446469000469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469000470 HAMP domain; Region: HAMP; pfam00672 446469000471 dimerization interface [polypeptide binding]; other site 446469000472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469000473 dimer interface [polypeptide binding]; other site 446469000474 phosphorylation site [posttranslational modification] 446469000475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469000476 ATP binding site [chemical binding]; other site 446469000477 Mg2+ binding site [ion binding]; other site 446469000478 G-X-G motif; other site 446469000479 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 446469000480 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 446469000481 seryl-tRNA synthetase; Provisional; Region: PRK05431 446469000482 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 446469000483 dimer interface [polypeptide binding]; other site 446469000484 active site 446469000485 motif 1; other site 446469000486 motif 2; other site 446469000487 motif 3; other site 446469000488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469000489 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 446469000490 active site 446469000491 motif I; other site 446469000492 motif II; other site 446469000493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469000494 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469000495 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469000496 DNA binding site [nucleotide binding] 446469000497 domain linker motif; other site 446469000498 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469000499 ligand binding site [chemical binding]; other site 446469000500 dimerization interface [polypeptide binding]; other site 446469000501 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469000502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000503 dimer interface [polypeptide binding]; other site 446469000504 conserved gate region; other site 446469000505 putative PBP binding loops; other site 446469000506 ABC-ATPase subunit interface; other site 446469000507 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469000508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000509 dimer interface [polypeptide binding]; other site 446469000510 conserved gate region; other site 446469000511 putative PBP binding loops; other site 446469000512 ABC-ATPase subunit interface; other site 446469000513 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 446469000514 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 446469000515 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 446469000516 NAD(P) binding site [chemical binding]; other site 446469000517 Nitrate and nitrite sensing; Region: NIT; pfam08376 446469000518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469000519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469000520 ATP binding site [chemical binding]; other site 446469000521 Mg2+ binding site [ion binding]; other site 446469000522 G-X-G motif; other site 446469000523 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 446469000524 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446469000525 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446469000526 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446469000527 G1 box; other site 446469000528 GTP/Mg2+ binding site [chemical binding]; other site 446469000529 G2 box; other site 446469000530 Switch I region; other site 446469000531 G3 box; other site 446469000532 Switch II region; other site 446469000533 G4 box; other site 446469000534 G5 box; other site 446469000535 alpha-galactosidase; Provisional; Region: PRK15076 446469000536 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 446469000537 NAD binding site [chemical binding]; other site 446469000538 sugar binding site [chemical binding]; other site 446469000539 divalent metal binding site [ion binding]; other site 446469000540 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 446469000541 dimer interface [polypeptide binding]; other site 446469000542 Amidohydrolase; Region: Amidohydro_2; pfam04909 446469000543 MarR family; Region: MarR_2; pfam12802 446469000544 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469000545 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446469000546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000547 dimer interface [polypeptide binding]; other site 446469000548 conserved gate region; other site 446469000549 putative PBP binding loops; other site 446469000550 ABC-ATPase subunit interface; other site 446469000551 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469000552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000553 dimer interface [polypeptide binding]; other site 446469000554 conserved gate region; other site 446469000555 putative PBP binding loops; other site 446469000556 ABC-ATPase subunit interface; other site 446469000557 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469000558 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446469000559 Melibiase; Region: Melibiase; pfam02065 446469000560 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446469000561 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 446469000562 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446469000563 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 446469000564 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446469000565 active site 446469000566 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 446469000567 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 446469000568 intersubunit interface [polypeptide binding]; other site 446469000569 active site 446469000570 zinc binding site [ion binding]; other site 446469000571 Na+ binding site [ion binding]; other site 446469000572 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446469000573 ATP binding site [chemical binding]; other site 446469000574 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469000575 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446469000576 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 446469000577 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446469000578 dimer interface [polypeptide binding]; other site 446469000579 active site 446469000580 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 446469000581 dimer interface [polypeptide binding]; other site 446469000582 active site 446469000583 Uncharacterized conserved protein [Function unknown]; Region: COG2966 446469000584 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 446469000585 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 446469000586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469000587 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469000588 putative substrate translocation pore; other site 446469000589 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 446469000590 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 446469000591 active site 446469000592 non-prolyl cis peptide bond; other site 446469000593 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446469000594 Isochorismatase family; Region: Isochorismatase; pfam00857 446469000595 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 446469000596 catalytic triad [active] 446469000597 conserved cis-peptide bond; other site 446469000598 pyrimidine utilization protein A; Region: RutA; TIGR03612 446469000599 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 446469000600 active site 446469000601 dimer interface [polypeptide binding]; other site 446469000602 non-prolyl cis peptide bond; other site 446469000603 insertion regions; other site 446469000604 NMT1/THI5 like; Region: NMT1; pfam09084 446469000605 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446469000606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000607 dimer interface [polypeptide binding]; other site 446469000608 conserved gate region; other site 446469000609 putative PBP binding loops; other site 446469000610 ABC-ATPase subunit interface; other site 446469000611 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446469000612 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446469000613 Walker A/P-loop; other site 446469000614 ATP binding site [chemical binding]; other site 446469000615 Q-loop/lid; other site 446469000616 ABC transporter signature motif; other site 446469000617 Walker B; other site 446469000618 D-loop; other site 446469000619 H-loop/switch region; other site 446469000620 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 446469000621 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 446469000622 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 446469000623 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 446469000624 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 446469000625 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 446469000626 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446469000627 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446469000628 Walker A/P-loop; other site 446469000629 ATP binding site [chemical binding]; other site 446469000630 Q-loop/lid; other site 446469000631 ABC transporter signature motif; other site 446469000632 Walker B; other site 446469000633 D-loop; other site 446469000634 H-loop/switch region; other site 446469000635 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469000636 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469000637 DNA binding residues [nucleotide binding] 446469000638 dimerization interface [polypeptide binding]; other site 446469000639 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 446469000640 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 446469000641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469000642 active site 446469000643 phosphorylation site [posttranslational modification] 446469000644 intermolecular recognition site; other site 446469000645 dimerization interface [polypeptide binding]; other site 446469000646 LytTr DNA-binding domain; Region: LytTR; smart00850 446469000647 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446469000648 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446469000649 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446469000650 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446469000651 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446469000652 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446469000653 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446469000654 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446469000655 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446469000656 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446469000657 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446469000658 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446469000659 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446469000660 active site 446469000661 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446469000662 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446469000663 active site 446469000664 Peptidase family C69; Region: Peptidase_C69; cl17793 446469000665 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446469000666 dimer interface [polypeptide binding]; other site 446469000667 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446469000668 HTH domain; Region: HTH_11; pfam08279 446469000669 WYL domain; Region: WYL; pfam13280 446469000670 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446469000671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446469000672 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 446469000673 active site pocket [active] 446469000674 oxyanion hole [active] 446469000675 catalytic triad [active] 446469000676 active site nucleophile [active] 446469000677 BCCT family transporter; Region: BCCT; pfam02028 446469000678 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 446469000679 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 446469000680 putative NAD(P) binding site [chemical binding]; other site 446469000681 catalytic Zn binding site [ion binding]; other site 446469000682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469000683 metabolite-proton symporter; Region: 2A0106; TIGR00883 446469000684 putative substrate translocation pore; other site 446469000685 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 446469000686 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 446469000687 putative active site pocket [active] 446469000688 putative metal binding site [ion binding]; other site 446469000689 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446469000690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469000691 DNA-binding site [nucleotide binding]; DNA binding site 446469000692 FCD domain; Region: FCD; pfam07729 446469000693 Predicted membrane protein [Function unknown]; Region: COG1971 446469000694 Domain of unknown function DUF; Region: DUF204; pfam02659 446469000695 Domain of unknown function DUF; Region: DUF204; pfam02659 446469000696 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446469000697 DinB superfamily; Region: DinB_2; pfam12867 446469000698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469000699 S-adenosylmethionine binding site [chemical binding]; other site 446469000700 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446469000701 DNA-binding site [nucleotide binding]; DNA binding site 446469000702 RNA-binding motif; other site 446469000703 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 446469000704 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446469000705 substrate binding pocket [chemical binding]; other site 446469000706 catalytic triad [active] 446469000707 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446469000708 DNA-binding site [nucleotide binding]; DNA binding site 446469000709 RNA-binding motif; other site 446469000710 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 446469000711 RNase_H superfamily; Region: RNase_H_2; pfam13482 446469000712 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469000713 ATP binding site [chemical binding]; other site 446469000714 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 446469000715 putative Mg++ binding site [ion binding]; other site 446469000716 AAA domain; Region: AAA_12; pfam13087 446469000717 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446469000718 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469000719 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469000720 active site 446469000721 catalytic tetrad [active] 446469000722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469000723 sequence-specific DNA binding site [nucleotide binding]; other site 446469000724 salt bridge; other site 446469000725 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446469000726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469000727 putative substrate translocation pore; other site 446469000728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446469000729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446469000730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446469000731 dimerization interface [polypeptide binding]; other site 446469000732 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446469000733 active site 446469000734 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 446469000735 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 446469000736 catalytic residues [active] 446469000737 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446469000738 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 446469000739 Walker A/P-loop; other site 446469000740 ATP binding site [chemical binding]; other site 446469000741 Q-loop/lid; other site 446469000742 ABC transporter signature motif; other site 446469000743 Walker B; other site 446469000744 D-loop; other site 446469000745 H-loop/switch region; other site 446469000746 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446469000747 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 446469000748 Excalibur calcium-binding domain; Region: Excalibur; smart00894 446469000749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 446469000750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469000751 ATP binding site [chemical binding]; other site 446469000752 Mg2+ binding site [ion binding]; other site 446469000753 G-X-G motif; other site 446469000754 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469000755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469000756 active site 446469000757 phosphorylation site [posttranslational modification] 446469000758 intermolecular recognition site; other site 446469000759 dimerization interface [polypeptide binding]; other site 446469000760 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469000761 DNA binding site [nucleotide binding] 446469000762 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 446469000763 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 446469000764 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 446469000765 ligand binding site [chemical binding]; other site 446469000766 beta-galactosidase; Region: BGL; TIGR03356 446469000767 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 446469000768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469000769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469000770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469000771 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446469000772 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446469000773 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 446469000774 active site 446469000775 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446469000776 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469000777 DNA binding residues [nucleotide binding] 446469000778 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446469000779 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469000780 alpha-galactosidase; Region: PLN02808; cl17638 446469000781 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469000782 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469000783 DNA binding site [nucleotide binding] 446469000784 domain linker motif; other site 446469000785 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469000786 ligand binding site [chemical binding]; other site 446469000787 dimerization interface [polypeptide binding]; other site 446469000788 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469000789 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469000790 DNA binding site [nucleotide binding] 446469000791 domain linker motif; other site 446469000792 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469000793 ligand binding site [chemical binding]; other site 446469000794 dimerization interface [polypeptide binding]; other site 446469000795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 446469000796 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 446469000797 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469000798 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446469000799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000800 dimer interface [polypeptide binding]; other site 446469000801 conserved gate region; other site 446469000802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446469000803 ABC-ATPase subunit interface; other site 446469000804 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469000805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000806 dimer interface [polypeptide binding]; other site 446469000807 conserved gate region; other site 446469000808 ABC-ATPase subunit interface; other site 446469000809 Protein of unknown function, DUF624; Region: DUF624; cl02369 446469000810 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 446469000811 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 446469000812 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 446469000813 putative active site [active] 446469000814 putative catalytic site [active] 446469000815 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 446469000816 AAA domain; Region: AAA_30; pfam13604 446469000817 Family description; Region: UvrD_C_2; pfam13538 446469000818 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446469000819 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 446469000820 active site 446469000821 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446469000822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469000823 DNA-binding site [nucleotide binding]; DNA binding site 446469000824 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446469000825 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469000826 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469000827 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 446469000828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000829 dimer interface [polypeptide binding]; other site 446469000830 conserved gate region; other site 446469000831 putative PBP binding loops; other site 446469000832 ABC-ATPase subunit interface; other site 446469000833 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469000834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000835 dimer interface [polypeptide binding]; other site 446469000836 conserved gate region; other site 446469000837 putative PBP binding loops; other site 446469000838 ABC-ATPase subunit interface; other site 446469000839 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 446469000840 intersubunit interface [polypeptide binding]; other site 446469000841 active site 446469000842 zinc binding site [ion binding]; other site 446469000843 Na+ binding site [ion binding]; other site 446469000844 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446469000845 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 446469000846 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 446469000847 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 446469000848 active site 446469000849 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446469000850 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446469000851 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469000852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000853 dimer interface [polypeptide binding]; other site 446469000854 conserved gate region; other site 446469000855 putative PBP binding loops; other site 446469000856 ABC-ATPase subunit interface; other site 446469000857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469000858 dimer interface [polypeptide binding]; other site 446469000859 conserved gate region; other site 446469000860 putative PBP binding loops; other site 446469000861 ABC-ATPase subunit interface; other site 446469000862 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469000863 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469000864 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469000865 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469000866 DNA binding site [nucleotide binding] 446469000867 domain linker motif; other site 446469000868 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469000869 dimerization interface [polypeptide binding]; other site 446469000870 ligand binding site [chemical binding]; other site 446469000871 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446469000872 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469000873 dimerization interface [polypeptide binding]; other site 446469000874 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469000875 dimer interface [polypeptide binding]; other site 446469000876 putative CheW interface [polypeptide binding]; other site 446469000877 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 446469000878 Domain of unknown function (DUF955); Region: DUF955; cl01076 446469000879 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 446469000880 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 446469000881 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 446469000882 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469000883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469000884 DNA binding residues [nucleotide binding] 446469000885 dimerization interface [polypeptide binding]; other site 446469000886 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446469000887 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446469000888 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 446469000889 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446469000890 Predicted flavoprotein [General function prediction only]; Region: COG0431 446469000891 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469000892 ATP binding site [chemical binding]; other site 446469000893 putative Mg++ binding site [ion binding]; other site 446469000894 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469000895 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 446469000896 nucleotide binding region [chemical binding]; other site 446469000897 ATP-binding site [chemical binding]; other site 446469000898 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 446469000899 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 446469000900 catalytic residues [active] 446469000901 catalytic nucleophile [active] 446469000902 Recombinase; Region: Recombinase; pfam07508 446469000903 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469000904 ATP-binding site [chemical binding]; other site 446469000905 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 446469000906 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446469000907 PLD-like domain; Region: PLDc_2; pfam13091 446469000908 putative active site [active] 446469000909 catalytic site [active] 446469000910 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446469000911 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446469000912 active site 446469000913 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469000914 MarR family; Region: MarR_2; pfam12802 446469000915 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 446469000916 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446469000917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469000918 non-specific DNA binding site [nucleotide binding]; other site 446469000919 salt bridge; other site 446469000920 sequence-specific DNA binding site [nucleotide binding]; other site 446469000921 Cupin domain; Region: Cupin_2; pfam07883 446469000922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469000923 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446469000924 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 446469000925 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 446469000926 active site 446469000927 catalytic site [active] 446469000928 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446469000929 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446469000930 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 446469000931 putative ligand binding site [chemical binding]; other site 446469000932 putative NAD binding site [chemical binding]; other site 446469000933 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446469000934 catalytic site [active] 446469000935 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 446469000936 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446469000937 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446469000938 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469000939 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469000940 dimerization interface [polypeptide binding]; other site 446469000941 ligand binding site [chemical binding]; other site 446469000942 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469000943 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469000944 PIN domain; Region: PIN_3; pfam13470 446469000945 Helix-turn-helix domain; Region: HTH_17; cl17695 446469000946 Uncharacterized conserved protein [Function unknown]; Region: COG1284 446469000947 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 446469000948 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 446469000949 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446469000950 Walker A/P-loop; other site 446469000951 ATP binding site [chemical binding]; other site 446469000952 Q-loop/lid; other site 446469000953 ABC transporter signature motif; other site 446469000954 Walker B; other site 446469000955 D-loop; other site 446469000956 H-loop/switch region; other site 446469000957 Histidine kinase; Region: HisKA_3; pfam07730 446469000958 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446469000959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469000960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469000961 active site 446469000962 phosphorylation site [posttranslational modification] 446469000963 intermolecular recognition site; other site 446469000964 dimerization interface [polypeptide binding]; other site 446469000965 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469000966 DNA binding residues [nucleotide binding] 446469000967 dimerization interface [polypeptide binding]; other site 446469000968 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 446469000969 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 446469000970 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 446469000971 active site 446469000972 dimer interface [polypeptide binding]; other site 446469000973 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 446469000974 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 446469000975 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 446469000976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 446469000977 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 446469000978 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 446469000979 HipA N-terminal domain; Region: Couple_hipA; pfam13657 446469000980 HipA-like N-terminal domain; Region: HipA_N; pfam07805 446469000981 HipA-like C-terminal domain; Region: HipA_C; pfam07804 446469000982 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446469000983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469000984 non-specific DNA binding site [nucleotide binding]; other site 446469000985 salt bridge; other site 446469000986 sequence-specific DNA binding site [nucleotide binding]; other site 446469000987 Cupin; Region: Cupin_6; pfam12852 446469000988 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 446469000989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446469000990 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 446469000991 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446469000992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469000993 DNA-binding site [nucleotide binding]; DNA binding site 446469000994 FCD domain; Region: FCD; pfam07729 446469000995 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469000996 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446469000997 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 446469000998 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446469000999 dimer interface [polypeptide binding]; other site 446469001000 conserved gate region; other site 446469001001 putative PBP binding loops; other site 446469001002 ABC-ATPase subunit interface; other site 446469001003 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469001004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001005 dimer interface [polypeptide binding]; other site 446469001006 conserved gate region; other site 446469001007 putative PBP binding loops; other site 446469001008 ABC-ATPase subunit interface; other site 446469001009 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 446469001010 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446469001011 metal binding site [ion binding]; metal-binding site 446469001012 substrate binding pocket [chemical binding]; other site 446469001013 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 446469001014 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446469001015 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446469001016 Uncharacterized conserved protein [Function unknown]; Region: COG1359 446469001017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469001018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469001019 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 446469001020 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 446469001021 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 446469001022 catalytic residues [active] 446469001023 Predicted membrane protein [Function unknown]; Region: COG4425 446469001024 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 446469001025 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 446469001026 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 446469001027 putative metal binding site [ion binding]; other site 446469001028 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446469001029 active site 446469001030 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446469001031 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446469001032 Walker A/P-loop; other site 446469001033 ATP binding site [chemical binding]; other site 446469001034 Q-loop/lid; other site 446469001035 ABC transporter signature motif; other site 446469001036 Walker B; other site 446469001037 D-loop; other site 446469001038 H-loop/switch region; other site 446469001039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446469001040 Histidine kinase; Region: HisKA_3; pfam07730 446469001041 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469001042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469001043 active site 446469001044 phosphorylation site [posttranslational modification] 446469001045 intermolecular recognition site; other site 446469001046 dimerization interface [polypeptide binding]; other site 446469001047 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469001048 DNA binding residues [nucleotide binding] 446469001049 dimerization interface [polypeptide binding]; other site 446469001050 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469001051 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469001052 DNA binding site [nucleotide binding] 446469001053 domain linker motif; other site 446469001054 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 446469001055 putative dimerization interface [polypeptide binding]; other site 446469001056 putative ligand binding site [chemical binding]; other site 446469001057 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469001058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001059 dimer interface [polypeptide binding]; other site 446469001060 conserved gate region; other site 446469001061 putative PBP binding loops; other site 446469001062 ABC-ATPase subunit interface; other site 446469001063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001064 dimer interface [polypeptide binding]; other site 446469001065 conserved gate region; other site 446469001066 putative PBP binding loops; other site 446469001067 ABC-ATPase subunit interface; other site 446469001068 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469001069 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446469001070 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446469001071 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446469001072 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446469001073 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446469001074 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446469001075 phosphopeptide binding site; other site 446469001076 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 446469001077 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446469001078 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 446469001079 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446469001080 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446469001081 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 446469001082 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446469001083 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 446469001084 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 446469001085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001086 dimer interface [polypeptide binding]; other site 446469001087 conserved gate region; other site 446469001088 putative PBP binding loops; other site 446469001089 ABC-ATPase subunit interface; other site 446469001090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001091 ABC-ATPase subunit interface; other site 446469001092 putative PBP binding loops; other site 446469001093 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 446469001094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469001095 Walker A/P-loop; other site 446469001096 ATP binding site [chemical binding]; other site 446469001097 Q-loop/lid; other site 446469001098 ABC transporter signature motif; other site 446469001099 Walker B; other site 446469001100 D-loop; other site 446469001101 H-loop/switch region; other site 446469001102 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 446469001103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469001104 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 446469001105 Walker A/P-loop; other site 446469001106 ATP binding site [chemical binding]; other site 446469001107 Q-loop/lid; other site 446469001108 ABC transporter signature motif; other site 446469001109 Walker B; other site 446469001110 D-loop; other site 446469001111 H-loop/switch region; other site 446469001112 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446469001113 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469001114 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 446469001115 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 446469001116 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 446469001117 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 446469001118 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 446469001119 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469001120 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469001121 DNA binding site [nucleotide binding] 446469001122 domain linker motif; other site 446469001123 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446469001124 ligand binding site [chemical binding]; other site 446469001125 dimerization interface (open form) [polypeptide binding]; other site 446469001126 dimerization interface (closed form) [polypeptide binding]; other site 446469001127 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 446469001128 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 446469001129 trimer interface [polypeptide binding]; other site 446469001130 active site 446469001131 substrate binding site [chemical binding]; other site 446469001132 CoA binding site [chemical binding]; other site 446469001133 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 446469001134 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446469001135 metal binding site [ion binding]; metal-binding site 446469001136 putative dimer interface [polypeptide binding]; other site 446469001137 Fn3 associated; Region: Fn3_assoc; pfam13287 446469001138 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 446469001139 active site 446469001140 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 446469001141 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446469001142 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446469001143 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446469001144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 446469001145 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446469001146 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446469001147 Interdomain contacts; other site 446469001148 Cytokine receptor motif; other site 446469001149 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446469001150 Interdomain contacts; other site 446469001151 Cytokine receptor motif; other site 446469001152 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 446469001153 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446469001154 DNA-binding site [nucleotide binding]; DNA binding site 446469001155 RNA-binding motif; other site 446469001156 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446469001157 DNA-binding site [nucleotide binding]; DNA binding site 446469001158 RNA-binding motif; other site 446469001159 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446469001160 DNA-binding site [nucleotide binding]; DNA binding site 446469001161 RNA-binding motif; other site 446469001162 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446469001163 DNA-binding site [nucleotide binding]; DNA binding site 446469001164 RNA-binding motif; other site 446469001165 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 446469001166 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446469001167 nucleotide binding site [chemical binding]; other site 446469001168 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 446469001169 dimer interface [polypeptide binding]; other site 446469001170 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 446469001171 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446469001172 HSP70 interaction site [polypeptide binding]; other site 446469001173 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 446469001174 substrate binding site [polypeptide binding]; other site 446469001175 dimer interface [polypeptide binding]; other site 446469001176 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446469001177 DNA binding residues [nucleotide binding] 446469001178 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446469001179 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 446469001180 putative active site [active] 446469001181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469001182 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469001183 DNA binding site [nucleotide binding] 446469001184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446469001185 active site 446469001186 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446469001187 nucleoside/Zn binding site; other site 446469001188 dimer interface [polypeptide binding]; other site 446469001189 catalytic motif [active] 446469001190 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 446469001191 NAD-dependent deacetylase; Provisional; Region: PRK05333 446469001192 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 446469001193 substrate binding site [chemical binding]; other site 446469001194 active site 446469001195 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 446469001196 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446469001197 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 446469001198 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 446469001199 putative catalytic motif [active] 446469001200 putative substrate binding site [chemical binding]; other site 446469001201 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 446469001202 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446469001203 intersubunit interface [polypeptide binding]; other site 446469001204 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446469001205 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469001206 ABC-ATPase subunit interface; other site 446469001207 dimer interface [polypeptide binding]; other site 446469001208 putative PBP binding regions; other site 446469001209 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469001210 ABC-ATPase subunit interface; other site 446469001211 dimer interface [polypeptide binding]; other site 446469001212 putative PBP binding regions; other site 446469001213 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 446469001214 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446469001215 Walker A/P-loop; other site 446469001216 ATP binding site [chemical binding]; other site 446469001217 Q-loop/lid; other site 446469001218 ABC transporter signature motif; other site 446469001219 Walker B; other site 446469001220 D-loop; other site 446469001221 H-loop/switch region; other site 446469001222 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 446469001223 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 446469001224 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 446469001225 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 446469001226 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 446469001227 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 446469001228 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 446469001229 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 446469001230 Walker A/P-loop; other site 446469001231 ATP binding site [chemical binding]; other site 446469001232 Q-loop/lid; other site 446469001233 ABC transporter signature motif; other site 446469001234 Walker B; other site 446469001235 D-loop; other site 446469001236 H-loop/switch region; other site 446469001237 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 446469001238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001239 ABC-ATPase subunit interface; other site 446469001240 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 446469001241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469001242 Walker A motif; other site 446469001243 ATP binding site [chemical binding]; other site 446469001244 Walker B motif; other site 446469001245 arginine finger; other site 446469001246 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 446469001247 recombination protein RecR; Reviewed; Region: recR; PRK00076 446469001248 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446469001249 RecR protein; Region: RecR; pfam02132 446469001250 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 446469001251 putative active site [active] 446469001252 putative metal-binding site [ion binding]; other site 446469001253 tetramer interface [polypeptide binding]; other site 446469001254 aspartate kinase; Reviewed; Region: PRK06635 446469001255 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 446469001256 putative nucleotide binding site [chemical binding]; other site 446469001257 putative catalytic residues [active] 446469001258 putative Mg ion binding site [ion binding]; other site 446469001259 putative aspartate binding site [chemical binding]; other site 446469001260 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 446469001261 putative allosteric regulatory site; other site 446469001262 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 446469001263 putative allosteric regulatory residue; other site 446469001264 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 446469001265 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 446469001266 Predicted transcriptional regulators [Transcription]; Region: COG1725 446469001267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469001268 DNA-binding site [nucleotide binding]; DNA binding site 446469001269 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446469001270 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446469001271 Walker A/P-loop; other site 446469001272 ATP binding site [chemical binding]; other site 446469001273 Q-loop/lid; other site 446469001274 ABC transporter signature motif; other site 446469001275 Walker B; other site 446469001276 D-loop; other site 446469001277 H-loop/switch region; other site 446469001278 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 446469001279 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 446469001280 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 446469001281 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 446469001282 TrkA-C domain; Region: TrkA_C; pfam02080 446469001283 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 446469001284 multifunctional aminopeptidase A; Provisional; Region: PRK00913 446469001285 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 446469001286 interface (dimer of trimers) [polypeptide binding]; other site 446469001287 Substrate-binding/catalytic site; other site 446469001288 Zn-binding sites [ion binding]; other site 446469001289 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 446469001290 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 446469001291 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 446469001292 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446469001293 putative active site [active] 446469001294 putative metal binding site [ion binding]; other site 446469001295 Transglycosylase; Region: Transgly; pfam00912 446469001296 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446469001297 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446469001298 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 446469001299 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 446469001300 homotrimer interaction site [polypeptide binding]; other site 446469001301 putative active site [active] 446469001302 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446469001303 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446469001304 ligand binding site [chemical binding]; other site 446469001305 flexible hinge region; other site 446469001306 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 446469001307 putative switch regulator; other site 446469001308 non-specific DNA interactions [nucleotide binding]; other site 446469001309 DNA binding site [nucleotide binding] 446469001310 sequence specific DNA binding site [nucleotide binding]; other site 446469001311 putative cAMP binding site [chemical binding]; other site 446469001312 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 446469001313 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446469001314 minor groove reading motif; other site 446469001315 helix-hairpin-helix signature motif; other site 446469001316 substrate binding pocket [chemical binding]; other site 446469001317 active site 446469001318 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 446469001319 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446469001320 Serine hydrolase (FSH1); Region: FSH1; pfam03959 446469001321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469001322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469001323 DNA binding site [nucleotide binding] 446469001324 DsrE/DsrF-like family; Region: DrsE; pfam02635 446469001325 nitrobindin heme-binding domain; Region: nitrobindin; cl10502 446469001326 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 446469001327 heme-binding site [chemical binding]; other site 446469001328 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 446469001329 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 446469001330 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446469001331 Predicted membrane protein [Function unknown]; Region: COG4129 446469001332 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 446469001333 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 446469001334 putative active site [active] 446469001335 dimerization interface [polypeptide binding]; other site 446469001336 putative tRNAtyr binding site [nucleotide binding]; other site 446469001337 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446469001338 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446469001339 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 446469001340 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 446469001341 Na binding site [ion binding]; other site 446469001342 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 446469001343 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 446469001344 active site 446469001345 dimer interface [polypeptide binding]; other site 446469001346 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 446469001347 dimer interface [polypeptide binding]; other site 446469001348 active site 446469001349 Clp protease ATP binding subunit; Region: clpC; CHL00095 446469001350 Clp amino terminal domain; Region: Clp_N; pfam02861 446469001351 Clp amino terminal domain; Region: Clp_N; pfam02861 446469001352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469001353 Walker A motif; other site 446469001354 ATP binding site [chemical binding]; other site 446469001355 Walker B motif; other site 446469001356 arginine finger; other site 446469001357 UvrB/uvrC motif; Region: UVR; pfam02151 446469001358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469001359 Walker A motif; other site 446469001360 ATP binding site [chemical binding]; other site 446469001361 Walker B motif; other site 446469001362 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446469001363 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446469001364 active site 446469001365 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 446469001366 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 446469001367 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 446469001368 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 446469001369 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 446469001370 Cysteine-rich domain; Region: CCG; pfam02754 446469001371 Cysteine-rich domain; Region: CCG; pfam02754 446469001372 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446469001373 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469001374 Walker A/P-loop; other site 446469001375 ATP binding site [chemical binding]; other site 446469001376 Q-loop/lid; other site 446469001377 ABC transporter signature motif; other site 446469001378 Walker B; other site 446469001379 D-loop; other site 446469001380 H-loop/switch region; other site 446469001381 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469001382 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446469001383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469001384 DNA-binding site [nucleotide binding]; DNA binding site 446469001385 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446469001386 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 446469001387 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 446469001388 Methane oxygenase PmoA; Region: PmoA; pfam14100 446469001389 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446469001390 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446469001391 Methane oxygenase PmoA; Region: PmoA; pfam14100 446469001392 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469001393 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469001394 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469001395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001396 dimer interface [polypeptide binding]; other site 446469001397 conserved gate region; other site 446469001398 putative PBP binding loops; other site 446469001399 ABC-ATPase subunit interface; other site 446469001400 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446469001401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001402 dimer interface [polypeptide binding]; other site 446469001403 putative PBP binding loops; other site 446469001404 ABC-ATPase subunit interface; other site 446469001405 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446469001406 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446469001407 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446469001408 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 446469001409 galactarate dehydratase; Region: galactar-dH20; TIGR03248 446469001410 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 446469001411 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446469001412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469001413 non-specific DNA binding site [nucleotide binding]; other site 446469001414 salt bridge; other site 446469001415 sequence-specific DNA binding site [nucleotide binding]; other site 446469001416 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446469001417 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446469001418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469001419 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446469001420 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469001421 DNA binding residues [nucleotide binding] 446469001422 glucuronate isomerase; Reviewed; Region: PRK02925 446469001423 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 446469001424 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469001425 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469001426 DNA binding site [nucleotide binding] 446469001427 domain linker motif; other site 446469001428 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469001429 ligand binding site [chemical binding]; other site 446469001430 dimerization interface [polypeptide binding]; other site 446469001431 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 446469001432 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 446469001433 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 446469001434 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 446469001435 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 446469001436 Cupin domain; Region: Cupin_2; pfam07883 446469001437 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 446469001438 active site 446469001439 catalytic triad [active] 446469001440 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446469001441 Interdomain contacts; other site 446469001442 Cytokine receptor motif; other site 446469001443 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 446469001444 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 446469001445 metal binding site [ion binding]; metal-binding site 446469001446 active site 446469001447 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469001448 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469001449 active site 446469001450 catalytic tetrad [active] 446469001451 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 446469001452 H+ Antiporter protein; Region: 2A0121; TIGR00900 446469001453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469001454 putative substrate translocation pore; other site 446469001455 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469001456 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469001457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001458 dimer interface [polypeptide binding]; other site 446469001459 conserved gate region; other site 446469001460 putative PBP binding loops; other site 446469001461 ABC-ATPase subunit interface; other site 446469001462 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469001463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001464 dimer interface [polypeptide binding]; other site 446469001465 conserved gate region; other site 446469001466 putative PBP binding loops; other site 446469001467 ABC-ATPase subunit interface; other site 446469001468 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 446469001469 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 446469001470 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 446469001471 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469001472 dimer interface [polypeptide binding]; other site 446469001473 putative CheW interface [polypeptide binding]; other site 446469001474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446469001475 PAS domain; Region: PAS_9; pfam13426 446469001476 putative active site [active] 446469001477 heme pocket [chemical binding]; other site 446469001478 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446469001479 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 446469001480 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446469001481 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446469001482 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446469001483 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446469001484 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446469001485 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446469001486 Methane oxygenase PmoA; Region: PmoA; pfam14100 446469001487 Cupin domain; Region: Cupin_2; cl17218 446469001488 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 446469001489 FHA domain; Region: FHA; pfam00498 446469001490 phosphopeptide binding site; other site 446469001491 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 446469001492 active site 446469001493 FHA domain; Region: FHA; pfam00498 446469001494 phosphopeptide binding site; other site 446469001495 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446469001496 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446469001497 active site 446469001498 ATP binding site [chemical binding]; other site 446469001499 substrate binding site [chemical binding]; other site 446469001500 activation loop (A-loop); other site 446469001501 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446469001502 Interdomain contacts; other site 446469001503 Cytokine receptor motif; other site 446469001504 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446469001505 Interdomain contacts; other site 446469001506 Cytokine receptor motif; other site 446469001507 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446469001508 Interdomain contacts; other site 446469001509 Cytokine receptor motif; other site 446469001510 MoxR-like ATPases [General function prediction only]; Region: COG0714 446469001511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469001512 Walker A motif; other site 446469001513 ATP binding site [chemical binding]; other site 446469001514 Walker B motif; other site 446469001515 arginine finger; other site 446469001516 Protein of unknown function DUF58; Region: DUF58; pfam01882 446469001517 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 446469001518 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446469001519 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446469001520 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 446469001521 Predicted transcriptional regulators [Transcription]; Region: COG1695 446469001522 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446469001523 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 446469001524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469001525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469001526 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446469001527 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469001528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001529 dimer interface [polypeptide binding]; other site 446469001530 conserved gate region; other site 446469001531 putative PBP binding loops; other site 446469001532 ABC-ATPase subunit interface; other site 446469001533 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446469001534 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 446469001535 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469001536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469001537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469001538 putative substrate translocation pore; other site 446469001539 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469001540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469001541 putative substrate translocation pore; other site 446469001542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469001543 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446469001544 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446469001545 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446469001546 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469001547 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469001548 DNA binding site [nucleotide binding] 446469001549 domain linker motif; other site 446469001550 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469001551 dimerization interface [polypeptide binding]; other site 446469001552 ligand binding site [chemical binding]; other site 446469001553 Domain of unknown function (DUF718); Region: DUF718; pfam05336 446469001554 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 446469001555 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 446469001556 short chain dehydrogenase; Validated; Region: PRK08324 446469001557 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 446469001558 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 446469001559 putative NAD(P) binding site [chemical binding]; other site 446469001560 active site 446469001561 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 446469001562 N- and C-terminal domain interface [polypeptide binding]; other site 446469001563 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 446469001564 active site 446469001565 putative catalytic site [active] 446469001566 metal binding site [ion binding]; metal-binding site 446469001567 ATP binding site [chemical binding]; other site 446469001568 carbohydrate binding site [chemical binding]; other site 446469001569 CAAX protease self-immunity; Region: Abi; pfam02517 446469001570 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 446469001571 putative dimer interface [polypeptide binding]; other site 446469001572 ligand binding site [chemical binding]; other site 446469001573 Zn binding site [ion binding]; other site 446469001574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446469001575 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446469001576 GAF domain; Region: GAF_2; pfam13185 446469001577 GAF domain; Region: GAF; pfam01590 446469001578 GAF domain; Region: GAF_2; pfam13185 446469001579 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446469001580 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469001581 dimer interface [polypeptide binding]; other site 446469001582 putative CheW interface [polypeptide binding]; other site 446469001583 Domain of unknown function DUF21; Region: DUF21; pfam01595 446469001584 FOG: CBS domain [General function prediction only]; Region: COG0517 446469001585 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446469001586 Domain of unknown function DUF21; Region: DUF21; pfam01595 446469001587 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446469001588 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446469001589 Transporter associated domain; Region: CorC_HlyC; pfam03471 446469001590 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 446469001591 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 446469001592 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446469001593 HAMP domain; Region: HAMP; pfam00672 446469001594 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469001595 dimer interface [polypeptide binding]; other site 446469001596 putative CheW interface [polypeptide binding]; other site 446469001597 mycothione reductase; Reviewed; Region: PRK07846 446469001598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446469001599 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446469001600 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446469001601 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446469001602 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446469001603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001604 putative PBP binding loops; other site 446469001605 ABC-ATPase subunit interface; other site 446469001606 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 446469001607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001608 dimer interface [polypeptide binding]; other site 446469001609 conserved gate region; other site 446469001610 putative PBP binding loops; other site 446469001611 ABC-ATPase subunit interface; other site 446469001612 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446469001613 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469001614 Walker A/P-loop; other site 446469001615 ATP binding site [chemical binding]; other site 446469001616 Q-loop/lid; other site 446469001617 ABC transporter signature motif; other site 446469001618 Walker B; other site 446469001619 D-loop; other site 446469001620 H-loop/switch region; other site 446469001621 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469001622 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 446469001623 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469001624 Walker A/P-loop; other site 446469001625 ATP binding site [chemical binding]; other site 446469001626 Q-loop/lid; other site 446469001627 ABC transporter signature motif; other site 446469001628 Walker B; other site 446469001629 D-loop; other site 446469001630 H-loop/switch region; other site 446469001631 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469001632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446469001633 hypothetical protein; Provisional; Region: PRK01346 446469001634 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446469001635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469001636 DNA-binding site [nucleotide binding]; DNA binding site 446469001637 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 446469001638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 446469001639 PAS fold; Region: PAS_4; pfam08448 446469001640 GAF domain; Region: GAF; cl17456 446469001641 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446469001642 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446469001643 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446469001644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446469001645 catalytic residue [active] 446469001646 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 446469001647 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 446469001648 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446469001649 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 446469001650 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 446469001651 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446469001652 G1 box; other site 446469001653 GTP/Mg2+ binding site [chemical binding]; other site 446469001654 G2 box; other site 446469001655 Switch I region; other site 446469001656 G3 box; other site 446469001657 Switch II region; other site 446469001658 G4 box; other site 446469001659 G5 box; other site 446469001660 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 446469001661 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 446469001662 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 446469001663 intersubunit interface [polypeptide binding]; other site 446469001664 active site 446469001665 Zn2+ binding site [ion binding]; other site 446469001666 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446469001667 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469001668 dimer interface [polypeptide binding]; other site 446469001669 putative CheW interface [polypeptide binding]; other site 446469001670 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469001671 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469001672 active site 446469001673 catalytic tetrad [active] 446469001674 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446469001675 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 446469001676 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469001677 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446469001678 xylose isomerase; Provisional; Region: PRK12677 446469001679 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 446469001680 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446469001681 D-xylulose kinase; Region: XylB; TIGR01312 446469001682 nucleotide binding site [chemical binding]; other site 446469001683 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 446469001684 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469001685 MarR family; Region: MarR; pfam01047 446469001686 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 446469001687 active site 446469001688 catalytic triad [active] 446469001689 oxyanion hole [active] 446469001690 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 446469001691 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 446469001692 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 446469001693 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446469001694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469001695 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446469001696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469001697 putative substrate translocation pore; other site 446469001698 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 446469001699 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 446469001700 NAD binding site [chemical binding]; other site 446469001701 catalytic Zn binding site [ion binding]; other site 446469001702 structural Zn binding site [ion binding]; other site 446469001703 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 446469001704 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446469001705 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446469001706 FAD binding domain; Region: FAD_binding_4; pfam01565 446469001707 Berberine and berberine like; Region: BBE; pfam08031 446469001708 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 446469001709 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446469001710 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469001711 MarR family; Region: MarR_2; pfam12802 446469001712 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469001713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001714 dimer interface [polypeptide binding]; other site 446469001715 conserved gate region; other site 446469001716 ABC-ATPase subunit interface; other site 446469001717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001718 dimer interface [polypeptide binding]; other site 446469001719 conserved gate region; other site 446469001720 putative PBP binding loops; other site 446469001721 ABC-ATPase subunit interface; other site 446469001722 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 446469001723 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446469001724 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469001725 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469001726 DNA binding site [nucleotide binding] 446469001727 domain linker motif; other site 446469001728 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 446469001729 ligand binding site [chemical binding]; other site 446469001730 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 446469001731 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 446469001732 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 446469001733 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 446469001734 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 446469001735 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 446469001736 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 446469001737 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 446469001738 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469001739 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469001740 DNA binding site [nucleotide binding] 446469001741 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469001742 ligand binding site [chemical binding]; other site 446469001743 dimerization interface [polypeptide binding]; other site 446469001744 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446469001745 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446469001746 substrate binding site [chemical binding]; other site 446469001747 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446469001748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001749 dimer interface [polypeptide binding]; other site 446469001750 conserved gate region; other site 446469001751 ABC-ATPase subunit interface; other site 446469001752 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446469001753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001754 dimer interface [polypeptide binding]; other site 446469001755 conserved gate region; other site 446469001756 putative PBP binding loops; other site 446469001757 ABC-ATPase subunit interface; other site 446469001758 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446469001759 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469001760 Walker A/P-loop; other site 446469001761 ATP binding site [chemical binding]; other site 446469001762 Q-loop/lid; other site 446469001763 ABC transporter signature motif; other site 446469001764 Walker B; other site 446469001765 D-loop; other site 446469001766 H-loop/switch region; other site 446469001767 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469001768 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469001769 Walker A/P-loop; other site 446469001770 ATP binding site [chemical binding]; other site 446469001771 Q-loop/lid; other site 446469001772 ABC transporter signature motif; other site 446469001773 Walker B; other site 446469001774 D-loop; other site 446469001775 H-loop/switch region; other site 446469001776 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 446469001777 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446469001778 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 446469001779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469001780 NAD(P) binding site [chemical binding]; other site 446469001781 active site 446469001782 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 446469001783 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446469001784 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446469001785 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446469001786 siderophore binding site; other site 446469001787 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446469001788 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469001789 ABC-ATPase subunit interface; other site 446469001790 dimer interface [polypeptide binding]; other site 446469001791 putative PBP binding regions; other site 446469001792 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 446469001793 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469001794 dimer interface [polypeptide binding]; other site 446469001795 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446469001796 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446469001797 Walker A/P-loop; other site 446469001798 ATP binding site [chemical binding]; other site 446469001799 Q-loop/lid; other site 446469001800 ABC transporter signature motif; other site 446469001801 Walker B; other site 446469001802 D-loop; other site 446469001803 H-loop/switch region; other site 446469001804 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 446469001805 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 446469001806 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 446469001807 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 446469001808 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 446469001809 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 446469001810 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446469001811 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446469001812 Tic20-like protein; Region: Tic20; pfam09685 446469001813 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446469001814 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446469001815 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446469001816 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 446469001817 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469001818 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469001819 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469001820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001821 dimer interface [polypeptide binding]; other site 446469001822 conserved gate region; other site 446469001823 putative PBP binding loops; other site 446469001824 ABC-ATPase subunit interface; other site 446469001825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001826 dimer interface [polypeptide binding]; other site 446469001827 conserved gate region; other site 446469001828 putative PBP binding loops; other site 446469001829 ABC-ATPase subunit interface; other site 446469001830 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469001831 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469001832 DNA binding site [nucleotide binding] 446469001833 domain linker motif; other site 446469001834 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446469001835 ligand binding site [chemical binding]; other site 446469001836 dimerization interface (open form) [polypeptide binding]; other site 446469001837 dimerization interface (closed form) [polypeptide binding]; other site 446469001838 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469001839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469001840 active site 446469001841 phosphorylation site [posttranslational modification] 446469001842 intermolecular recognition site; other site 446469001843 dimerization interface [polypeptide binding]; other site 446469001844 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469001845 DNA binding residues [nucleotide binding] 446469001846 dimerization interface [polypeptide binding]; other site 446469001847 Histidine kinase; Region: HisKA_3; pfam07730 446469001848 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446469001849 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446469001850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469001851 Coenzyme A binding pocket [chemical binding]; other site 446469001852 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446469001853 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446469001854 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446469001855 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 446469001856 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469001857 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469001858 DNA binding site [nucleotide binding] 446469001859 domain linker motif; other site 446469001860 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469001861 ligand binding site [chemical binding]; other site 446469001862 dimerization interface [polypeptide binding]; other site 446469001863 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 446469001864 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 446469001865 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 446469001866 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 446469001867 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 446469001868 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 446469001869 active site 446469001870 DNA binding site [nucleotide binding] 446469001871 catalytic site [active] 446469001872 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 446469001873 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 446469001874 active site 446469001875 HIGH motif; other site 446469001876 dimer interface [polypeptide binding]; other site 446469001877 KMSKS motif; other site 446469001878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469001879 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446469001880 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 446469001881 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 446469001882 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 446469001883 active site 446469001884 substrate-binding site [chemical binding]; other site 446469001885 metal-binding site [ion binding] 446469001886 GTP binding site [chemical binding]; other site 446469001887 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446469001888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469001889 non-specific DNA binding site [nucleotide binding]; other site 446469001890 salt bridge; other site 446469001891 sequence-specific DNA binding site [nucleotide binding]; other site 446469001892 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 446469001893 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446469001894 glycerol kinase; Provisional; Region: glpK; PRK00047 446469001895 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 446469001896 N- and C-terminal domain interface [polypeptide binding]; other site 446469001897 active site 446469001898 MgATP binding site [chemical binding]; other site 446469001899 catalytic site [active] 446469001900 metal binding site [ion binding]; metal-binding site 446469001901 putative homotetramer interface [polypeptide binding]; other site 446469001902 glycerol binding site [chemical binding]; other site 446469001903 homodimer interface [polypeptide binding]; other site 446469001904 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 446469001905 amphipathic channel; other site 446469001906 Asn-Pro-Ala signature motifs; other site 446469001907 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 446469001908 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 446469001909 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469001910 DNA binding residues [nucleotide binding] 446469001911 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 446469001912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469001913 Coenzyme A binding pocket [chemical binding]; other site 446469001914 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 446469001915 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446469001916 minor groove reading motif; other site 446469001917 helix-hairpin-helix signature motif; other site 446469001918 active site 446469001919 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 446469001920 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 446469001921 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 446469001922 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 446469001923 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446469001924 DNA repair protein RadA; Provisional; Region: PRK11823 446469001925 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446469001926 Walker A motif; other site 446469001927 ATP binding site [chemical binding]; other site 446469001928 Walker B motif; other site 446469001929 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 446469001930 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469001931 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469001932 DNA binding site [nucleotide binding] 446469001933 domain linker motif; other site 446469001934 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446469001935 ligand binding site [chemical binding]; other site 446469001936 dimerization interface (open form) [polypeptide binding]; other site 446469001937 dimerization interface (closed form) [polypeptide binding]; other site 446469001938 ribulokinase; Provisional; Region: PRK04123 446469001939 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 446469001940 N- and C-terminal domain interface [polypeptide binding]; other site 446469001941 active site 446469001942 MgATP binding site [chemical binding]; other site 446469001943 catalytic site [active] 446469001944 metal binding site [ion binding]; metal-binding site 446469001945 carbohydrate binding site [chemical binding]; other site 446469001946 homodimer interface [polypeptide binding]; other site 446469001947 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 446469001948 intersubunit interface [polypeptide binding]; other site 446469001949 active site 446469001950 Zn2+ binding site [ion binding]; other site 446469001951 L-arabinose isomerase; Provisional; Region: PRK02929 446469001952 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 446469001953 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 446469001954 trimer interface [polypeptide binding]; other site 446469001955 putative substrate binding site [chemical binding]; other site 446469001956 putative metal binding site [ion binding]; other site 446469001957 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446469001958 TrkA-N domain; Region: TrkA_N; pfam02254 446469001959 TrkA-C domain; Region: TrkA_C; pfam02080 446469001960 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 446469001961 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 446469001962 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 446469001963 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 446469001964 active site 446469001965 Zn binding site [ion binding]; other site 446469001966 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469001967 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469001968 DNA binding site [nucleotide binding] 446469001969 domain linker motif; other site 446469001970 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469001971 dimerization interface [polypeptide binding]; other site 446469001972 ligand binding site [chemical binding]; other site 446469001973 Sterol carrier protein domain; Region: SCP2_2; pfam13530 446469001974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469001975 S-adenosylmethionine binding site [chemical binding]; other site 446469001976 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446469001977 Radical SAM superfamily; Region: Radical_SAM; pfam04055 446469001978 FeS/SAM binding site; other site 446469001979 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 446469001980 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446469001981 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469001982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001983 dimer interface [polypeptide binding]; other site 446469001984 conserved gate region; other site 446469001985 putative PBP binding loops; other site 446469001986 ABC-ATPase subunit interface; other site 446469001987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446469001988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469001989 ABC-ATPase subunit interface; other site 446469001990 putative PBP binding loops; other site 446469001991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469001992 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469001993 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446469001994 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 446469001995 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 446469001996 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446469001997 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446469001998 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 446469001999 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 446469002000 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 446469002001 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 446469002002 CoA binding domain; Region: CoA_binding; pfam02629 446469002003 Uncharacterized conserved protein [Function unknown]; Region: COG2353 446469002004 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469002005 MarR family; Region: MarR; pfam01047 446469002006 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446469002007 catalytic core [active] 446469002008 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 446469002009 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446469002010 catalytic residues [active] 446469002011 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 446469002012 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 446469002013 ResB-like family; Region: ResB; pfam05140 446469002014 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 446469002015 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 446469002016 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 446469002017 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 446469002018 UbiA prenyltransferase family; Region: UbiA; pfam01040 446469002019 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446469002020 acyl-activating enzyme (AAE) consensus motif; other site 446469002021 AMP binding site [chemical binding]; other site 446469002022 active site 446469002023 CoA binding site [chemical binding]; other site 446469002024 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 446469002025 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446469002026 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 446469002027 substrate binding site [chemical binding]; other site 446469002028 oxyanion hole (OAH) forming residues; other site 446469002029 trimer interface [polypeptide binding]; other site 446469002030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 446469002031 O-succinylbenzoate synthase; Provisional; Region: PRK02901 446469002032 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 446469002033 active site 446469002034 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 446469002035 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 446469002036 PYR/PP interface [polypeptide binding]; other site 446469002037 dimer interface [polypeptide binding]; other site 446469002038 TPP binding site [chemical binding]; other site 446469002039 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 446469002040 TPP-binding site; other site 446469002041 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446469002042 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 446469002043 protein binding site [polypeptide binding]; other site 446469002044 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446469002045 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 446469002046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469002047 S-adenosylmethionine binding site [chemical binding]; other site 446469002048 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 446469002049 NADH dehydrogenase subunit A; Validated; Region: PRK07928 446469002050 NADH dehydrogenase subunit B; Validated; Region: PRK06411 446469002051 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 446469002052 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 446469002053 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 446469002054 NADH dehydrogenase subunit D; Validated; Region: PRK06075 446469002055 NADH dehydrogenase subunit E; Validated; Region: PRK07539 446469002056 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 446469002057 putative dimer interface [polypeptide binding]; other site 446469002058 [2Fe-2S] cluster binding site [ion binding]; other site 446469002059 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 446469002060 SLBB domain; Region: SLBB; pfam10531 446469002061 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 446469002062 NADH dehydrogenase subunit G; Validated; Region: PRK07860 446469002063 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446469002064 catalytic loop [active] 446469002065 iron binding site [ion binding]; other site 446469002066 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 446469002067 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446469002068 molybdopterin cofactor binding site; other site 446469002069 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 446469002070 molybdopterin cofactor binding site; other site 446469002071 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 446469002072 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 446469002073 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 446469002074 4Fe-4S binding domain; Region: Fer4; pfam00037 446469002075 4Fe-4S binding domain; Region: Fer4; pfam00037 446469002076 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 446469002077 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 446469002078 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 446469002079 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 446469002080 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 446469002081 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446469002082 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 446469002083 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446469002084 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 446469002085 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446469002086 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446469002087 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446469002088 substrate binding pocket [chemical binding]; other site 446469002089 chain length determination region; other site 446469002090 substrate-Mg2+ binding site; other site 446469002091 catalytic residues [active] 446469002092 aspartate-rich region 1; other site 446469002093 active site lid residues [active] 446469002094 aspartate-rich region 2; other site 446469002095 Protein phosphatase 2C; Region: PP2C; pfam00481 446469002096 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446469002097 active site 446469002098 FHA domain; Region: FHA; pfam00498 446469002099 phosphopeptide binding site; other site 446469002100 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446469002101 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446469002102 active site 446469002103 ATP binding site [chemical binding]; other site 446469002104 substrate binding site [chemical binding]; other site 446469002105 activation loop (A-loop); other site 446469002106 ferredoxin-NADP+ reductase; Region: PLN02852 446469002107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446469002108 heat shock protein HtpX; Provisional; Region: PRK03072 446469002109 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469002110 dimerization interface [polypeptide binding]; other site 446469002111 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446469002112 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469002113 dimer interface [polypeptide binding]; other site 446469002114 putative CheW interface [polypeptide binding]; other site 446469002115 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 446469002116 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446469002117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 446469002118 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 446469002119 Predicted permeases [General function prediction only]; Region: RarD; COG2962 446469002120 EamA-like transporter family; Region: EamA; pfam00892 446469002121 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 446469002122 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 446469002123 active site 446469002124 catalytic site [active] 446469002125 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446469002126 active site 2 [active] 446469002127 active site 1 [active] 446469002128 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469002129 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469002130 DNA binding site [nucleotide binding] 446469002131 domain linker motif; other site 446469002132 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446469002133 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 446469002134 FAD binding domain; Region: FAD_binding_4; pfam01565 446469002135 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 446469002136 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 446469002137 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446469002138 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 446469002139 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 446469002140 N- and C-terminal domain interface [polypeptide binding]; other site 446469002141 active site 446469002142 carbohydrate binding site [chemical binding]; other site 446469002143 ATP binding site [chemical binding]; other site 446469002144 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 446469002145 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 446469002146 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 446469002147 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469002148 ATP binding site [chemical binding]; other site 446469002149 putative Mg++ binding site [ion binding]; other site 446469002150 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469002151 nucleotide binding region [chemical binding]; other site 446469002152 ATP-binding site [chemical binding]; other site 446469002153 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 446469002154 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446469002155 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 446469002156 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 446469002157 ligand binding site [chemical binding]; other site 446469002158 homodimer interface [polypeptide binding]; other site 446469002159 NAD(P) binding site [chemical binding]; other site 446469002160 trimer interface B [polypeptide binding]; other site 446469002161 trimer interface A [polypeptide binding]; other site 446469002162 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 446469002163 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 446469002164 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 446469002165 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 446469002166 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 446469002167 homodimer interface [polypeptide binding]; other site 446469002168 metal binding site [ion binding]; metal-binding site 446469002169 enolase; Provisional; Region: eno; PRK00077 446469002170 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 446469002171 dimer interface [polypeptide binding]; other site 446469002172 metal binding site [ion binding]; metal-binding site 446469002173 substrate binding pocket [chemical binding]; other site 446469002174 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 446469002175 Septum formation initiator; Region: DivIC; pfam04977 446469002176 Protein of unknown function (DUF501); Region: DUF501; cl00652 446469002177 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 446469002178 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 446469002179 Predicted transcriptional regulators [Transcription]; Region: COG1695 446469002180 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446469002181 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446469002182 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446469002183 Abi-like protein; Region: Abi_2; pfam07751 446469002184 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446469002185 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446469002186 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446469002187 siderophore binding site; other site 446469002188 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 446469002189 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 446469002190 Protease prsW family; Region: PrsW-protease; pfam13367 446469002191 YKOF-related Family; Region: Ykof; pfam07615 446469002192 YKOF-related Family; Region: Ykof; pfam07615 446469002193 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 446469002194 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446469002195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469002196 Walker A/P-loop; other site 446469002197 ATP binding site [chemical binding]; other site 446469002198 Q-loop/lid; other site 446469002199 ABC transporter signature motif; other site 446469002200 Walker B; other site 446469002201 D-loop; other site 446469002202 H-loop/switch region; other site 446469002203 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446469002204 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 446469002205 Walker A/P-loop; other site 446469002206 ATP binding site [chemical binding]; other site 446469002207 Q-loop/lid; other site 446469002208 ABC transporter signature motif; other site 446469002209 Walker B; other site 446469002210 D-loop; other site 446469002211 H-loop/switch region; other site 446469002212 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 446469002213 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 446469002214 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446469002215 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 446469002216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469002217 dimerization interface [polypeptide binding]; other site 446469002218 putative DNA binding site [nucleotide binding]; other site 446469002219 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469002220 putative Zn2+ binding site [ion binding]; other site 446469002221 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 446469002222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469002223 dimer interface [polypeptide binding]; other site 446469002224 phosphorylation site [posttranslational modification] 446469002225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469002226 ATP binding site [chemical binding]; other site 446469002227 Mg2+ binding site [ion binding]; other site 446469002228 G-X-G motif; other site 446469002229 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 446469002230 FAD binding domain; Region: FAD_binding_2; pfam00890 446469002231 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446469002232 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 446469002233 Walker A/P-loop; other site 446469002234 ATP binding site [chemical binding]; other site 446469002235 Q-loop/lid; other site 446469002236 ABC transporter signature motif; other site 446469002237 Walker B; other site 446469002238 D-loop; other site 446469002239 H-loop/switch region; other site 446469002240 Bax inhibitor 1 like; Region: BaxI_1; cl17691 446469002241 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446469002242 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446469002243 dimerization interface [polypeptide binding]; other site 446469002244 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 446469002245 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446469002246 methionine sulfoxide reductase A; Provisional; Region: PRK00058 446469002247 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 446469002248 Domain of unknown function DUF20; Region: UPF0118; pfam01594 446469002249 threonine dehydratase; Provisional; Region: PRK08198 446469002250 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 446469002251 tetramer interface [polypeptide binding]; other site 446469002252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469002253 catalytic residue [active] 446469002254 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 446469002255 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 446469002256 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 446469002257 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 446469002258 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 446469002259 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446469002260 Predicted amidohydrolase [General function prediction only]; Region: COG0388 446469002261 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 446469002262 putative active site [active] 446469002263 catalytic triad [active] 446469002264 putative dimer interface [polypeptide binding]; other site 446469002265 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 446469002266 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 446469002267 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 446469002268 catalytic residue [active] 446469002269 putative FPP diphosphate binding site; other site 446469002270 putative FPP binding hydrophobic cleft; other site 446469002271 dimer interface [polypeptide binding]; other site 446469002272 putative IPP diphosphate binding site; other site 446469002273 Predicted ATPase [General function prediction only]; Region: COG4637 446469002274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469002275 Walker A/P-loop; other site 446469002276 ATP binding site [chemical binding]; other site 446469002277 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446469002278 homotrimer interaction site [polypeptide binding]; other site 446469002279 putative active site [active] 446469002280 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 446469002281 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446469002282 catalytic residue [active] 446469002283 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446469002284 Amidohydrolase family; Region: Amidohydro_3; pfam07969 446469002285 active site 446469002286 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446469002287 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 446469002288 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 446469002289 active site 446469002290 Putative zinc-finger; Region: zf-HC2; pfam13490 446469002291 ferrochelatase; Reviewed; Region: hemH; PRK00035 446469002292 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 446469002293 C-terminal domain interface [polypeptide binding]; other site 446469002294 active site 446469002295 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 446469002296 active site 446469002297 N-terminal domain interface [polypeptide binding]; other site 446469002298 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 446469002299 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 446469002300 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 446469002301 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 446469002302 NAD(P) binding site [chemical binding]; other site 446469002303 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446469002304 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469002305 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469002306 DNA binding site [nucleotide binding] 446469002307 domain linker motif; other site 446469002308 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 446469002309 putative dimerization interface [polypeptide binding]; other site 446469002310 putative ligand binding site [chemical binding]; other site 446469002311 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446469002312 beta-galactosidase; Region: BGL; TIGR03356 446469002313 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469002314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469002315 dimer interface [polypeptide binding]; other site 446469002316 conserved gate region; other site 446469002317 putative PBP binding loops; other site 446469002318 ABC-ATPase subunit interface; other site 446469002319 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446469002320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469002321 ABC-ATPase subunit interface; other site 446469002322 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469002323 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 446469002324 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 446469002325 PAS fold; Region: PAS_4; pfam08448 446469002326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 446469002327 Histidine kinase; Region: HisKA_2; pfam07568 446469002328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469002329 ATP binding site [chemical binding]; other site 446469002330 Mg2+ binding site [ion binding]; other site 446469002331 G-X-G motif; other site 446469002332 Transcription factor WhiB; Region: Whib; pfam02467 446469002333 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446469002334 FtsX-like permease family; Region: FtsX; pfam02687 446469002335 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446469002336 FtsX-like permease family; Region: FtsX; pfam02687 446469002337 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446469002338 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446469002339 Walker A/P-loop; other site 446469002340 ATP binding site [chemical binding]; other site 446469002341 Q-loop/lid; other site 446469002342 ABC transporter signature motif; other site 446469002343 Walker B; other site 446469002344 D-loop; other site 446469002345 H-loop/switch region; other site 446469002346 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469002347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469002348 active site 446469002349 phosphorylation site [posttranslational modification] 446469002350 intermolecular recognition site; other site 446469002351 dimerization interface [polypeptide binding]; other site 446469002352 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469002353 DNA binding residues [nucleotide binding] 446469002354 dimerization interface [polypeptide binding]; other site 446469002355 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446469002356 Histidine kinase; Region: HisKA_3; pfam07730 446469002357 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446469002358 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469002359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469002360 active site 446469002361 phosphorylation site [posttranslational modification] 446469002362 intermolecular recognition site; other site 446469002363 dimerization interface [polypeptide binding]; other site 446469002364 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469002365 DNA binding site [nucleotide binding] 446469002366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469002367 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 446469002368 dimerization interface [polypeptide binding]; other site 446469002369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469002370 dimer interface [polypeptide binding]; other site 446469002371 phosphorylation site [posttranslational modification] 446469002372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469002373 Mg2+ binding site [ion binding]; other site 446469002374 G-X-G motif; other site 446469002375 Predicted membrane protein [Function unknown]; Region: COG2246 446469002376 GtrA-like protein; Region: GtrA; pfam04138 446469002377 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 446469002378 Pleckstrin homology-like domain; Region: PH-like; cl17171 446469002379 ATP-grasp domain; Region: ATP-grasp; pfam02222 446469002380 AIR carboxylase; Region: AIRC; pfam00731 446469002381 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 446469002382 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 446469002383 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446469002384 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 446469002385 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446469002386 Ligand binding site; other site 446469002387 Putative Catalytic site; other site 446469002388 DXD motif; other site 446469002389 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 446469002390 putative CoA binding site [chemical binding]; other site 446469002391 putative trimer interface [polypeptide binding]; other site 446469002392 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 446469002393 putative trimer interface [polypeptide binding]; other site 446469002394 putative active site [active] 446469002395 putative substrate binding site [chemical binding]; other site 446469002396 putative CoA binding site [chemical binding]; other site 446469002397 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 446469002398 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446469002399 inhibitor-cofactor binding pocket; inhibition site 446469002400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469002401 catalytic residue [active] 446469002402 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446469002403 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446469002404 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446469002405 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446469002406 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 446469002407 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446469002408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469002409 Walker A/P-loop; other site 446469002410 ATP binding site [chemical binding]; other site 446469002411 Q-loop/lid; other site 446469002412 ABC transporter signature motif; other site 446469002413 Walker B; other site 446469002414 D-loop; other site 446469002415 H-loop/switch region; other site 446469002416 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446469002417 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446469002418 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446469002419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469002420 non-specific DNA binding site [nucleotide binding]; other site 446469002421 salt bridge; other site 446469002422 sequence-specific DNA binding site [nucleotide binding]; other site 446469002423 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 446469002424 active site 446469002425 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 446469002426 homodimer interface [polypeptide binding]; other site 446469002427 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446469002428 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446469002429 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446469002430 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446469002431 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446469002432 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 446469002433 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446469002434 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 446469002435 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446469002436 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446469002437 active site 446469002438 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446469002439 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446469002440 active site 446469002441 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446469002442 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 446469002443 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 446469002444 active site 446469002445 homodimer interface [polypeptide binding]; other site 446469002446 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 446469002447 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446469002448 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 446469002449 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 446469002450 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 446469002451 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 446469002452 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 446469002453 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 446469002454 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446469002455 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 446469002456 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446469002457 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 446469002458 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 446469002459 Walker A/P-loop; other site 446469002460 ATP binding site [chemical binding]; other site 446469002461 Q-loop/lid; other site 446469002462 ABC transporter signature motif; other site 446469002463 Walker B; other site 446469002464 D-loop; other site 446469002465 H-loop/switch region; other site 446469002466 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 446469002467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446469002468 UDP-galactopyranose mutase; Region: GLF; pfam03275 446469002469 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446469002470 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446469002471 active site 446469002472 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 446469002473 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 446469002474 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 446469002475 Walker A/P-loop; other site 446469002476 ATP binding site [chemical binding]; other site 446469002477 Q-loop/lid; other site 446469002478 ABC transporter signature motif; other site 446469002479 Walker B; other site 446469002480 D-loop; other site 446469002481 H-loop/switch region; other site 446469002482 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 446469002483 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 446469002484 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 446469002485 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 446469002486 NAD binding site [chemical binding]; other site 446469002487 substrate binding site [chemical binding]; other site 446469002488 homodimer interface [polypeptide binding]; other site 446469002489 active site 446469002490 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446469002491 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446469002492 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446469002493 Ligand binding site; other site 446469002494 Putative Catalytic site; other site 446469002495 DXD motif; other site 446469002496 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 446469002497 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446469002498 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446469002499 active site 446469002500 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446469002501 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 446469002502 Probable Catalytic site; other site 446469002503 metal-binding site 446469002504 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 446469002505 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 446469002506 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 446469002507 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 446469002508 NADP binding site [chemical binding]; other site 446469002509 active site 446469002510 putative substrate binding site [chemical binding]; other site 446469002511 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 446469002512 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 446469002513 substrate binding site; other site 446469002514 tetramer interface; other site 446469002515 TIGR03089 family protein; Region: TIGR03089 446469002516 Transcription factor WhiB; Region: Whib; pfam02467 446469002517 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446469002518 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 446469002519 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 446469002520 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 446469002521 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 446469002522 active site 446469002523 substrate binding site [chemical binding]; other site 446469002524 metal binding site [ion binding]; metal-binding site 446469002525 Trm112p-like protein; Region: Trm112p; cl01066 446469002526 short chain dehydrogenase; Provisional; Region: PRK06197 446469002527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469002528 NAD(P) binding site [chemical binding]; other site 446469002529 active site 446469002530 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 446469002531 Cation efflux family; Region: Cation_efflux; pfam01545 446469002532 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 446469002533 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 446469002534 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 446469002535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469002536 dimer interface [polypeptide binding]; other site 446469002537 conserved gate region; other site 446469002538 putative PBP binding loops; other site 446469002539 ABC-ATPase subunit interface; other site 446469002540 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 446469002541 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 446469002542 Walker A/P-loop; other site 446469002543 ATP binding site [chemical binding]; other site 446469002544 Q-loop/lid; other site 446469002545 ABC transporter signature motif; other site 446469002546 Walker B; other site 446469002547 D-loop; other site 446469002548 H-loop/switch region; other site 446469002549 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 446469002550 Adenosylhomocysteinase; Provisional; Region: PTZ00075 446469002551 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 446469002552 homotetramer interface [polypeptide binding]; other site 446469002553 ligand binding site [chemical binding]; other site 446469002554 catalytic site [active] 446469002555 NAD binding site [chemical binding]; other site 446469002556 Putative sensor; Region: Sensor; pfam13796 446469002557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446469002558 Histidine kinase; Region: HisKA_3; pfam07730 446469002559 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469002560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469002561 active site 446469002562 phosphorylation site [posttranslational modification] 446469002563 intermolecular recognition site; other site 446469002564 dimerization interface [polypeptide binding]; other site 446469002565 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469002566 DNA binding residues [nucleotide binding] 446469002567 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 446469002568 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 446469002569 Domain of unknown function DUF11; Region: DUF11; pfam01345 446469002570 RDD family; Region: RDD; pfam06271 446469002571 Integral membrane protein DUF95; Region: DUF95; pfam01944 446469002572 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446469002573 Protein of unknown function DUF58; Region: DUF58; pfam01882 446469002574 MoxR-like ATPases [General function prediction only]; Region: COG0714 446469002575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469002576 Walker A motif; other site 446469002577 ATP binding site [chemical binding]; other site 446469002578 Walker B motif; other site 446469002579 arginine finger; other site 446469002580 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 446469002581 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 446469002582 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469002583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469002584 active site 446469002585 phosphorylation site [posttranslational modification] 446469002586 intermolecular recognition site; other site 446469002587 dimerization interface [polypeptide binding]; other site 446469002588 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469002589 DNA binding site [nucleotide binding] 446469002590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469002591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469002592 dimerization interface [polypeptide binding]; other site 446469002593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469002594 dimer interface [polypeptide binding]; other site 446469002595 phosphorylation site [posttranslational modification] 446469002596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469002597 ATP binding site [chemical binding]; other site 446469002598 G-X-G motif; other site 446469002599 lipoprotein LpqB; Provisional; Region: PRK13614 446469002600 Sporulation and spore germination; Region: Germane; pfam10646 446469002601 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 446469002602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446469002603 active site 446469002604 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 446469002605 30S subunit binding site; other site 446469002606 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446469002607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 446469002608 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446469002609 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469002610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469002611 Walker A/P-loop; other site 446469002612 ATP binding site [chemical binding]; other site 446469002613 Q-loop/lid; other site 446469002614 ABC transporter signature motif; other site 446469002615 Walker B; other site 446469002616 D-loop; other site 446469002617 H-loop/switch region; other site 446469002618 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469002619 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 446469002620 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446469002621 Walker A/P-loop; other site 446469002622 ATP binding site [chemical binding]; other site 446469002623 Q-loop/lid; other site 446469002624 ABC transporter signature motif; other site 446469002625 Walker B; other site 446469002626 D-loop; other site 446469002627 H-loop/switch region; other site 446469002628 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 446469002629 DEAD/DEAH box helicase; Region: DEAD; pfam00270 446469002630 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 446469002631 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446469002632 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 446469002633 active site 446469002634 ribosome small subunit-dependent GTPase A; Region: TIGR00157 446469002635 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 446469002636 GTPase/Zn-binding domain interface [polypeptide binding]; other site 446469002637 GTP/Mg2+ binding site [chemical binding]; other site 446469002638 G4 box; other site 446469002639 G5 box; other site 446469002640 G1 box; other site 446469002641 Switch I region; other site 446469002642 G2 box; other site 446469002643 G3 box; other site 446469002644 Switch II region; other site 446469002645 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 446469002646 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 446469002647 hinge; other site 446469002648 active site 446469002649 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 446469002650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469002651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469002652 DNA binding residues [nucleotide binding] 446469002653 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 446469002654 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 446469002655 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446469002656 Walker A motif; other site 446469002657 ATP binding site [chemical binding]; other site 446469002658 Walker B motif; other site 446469002659 Uncharacterized conserved protein [Function unknown]; Region: COG3595 446469002660 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446469002661 active site 446469002662 catalytic triad [active] 446469002663 oxyanion hole [active] 446469002664 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 446469002665 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446469002666 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 446469002667 TPP-binding site [chemical binding]; other site 446469002668 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 446469002669 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446469002670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469002671 Walker A/P-loop; other site 446469002672 ATP binding site [chemical binding]; other site 446469002673 Q-loop/lid; other site 446469002674 ABC transporter signature motif; other site 446469002675 Walker B; other site 446469002676 D-loop; other site 446469002677 H-loop/switch region; other site 446469002678 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469002679 dimerization interface [polypeptide binding]; other site 446469002680 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469002681 dimer interface [polypeptide binding]; other site 446469002682 phosphorylation site [posttranslational modification] 446469002683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469002684 ATP binding site [chemical binding]; other site 446469002685 Mg2+ binding site [ion binding]; other site 446469002686 G-X-G motif; other site 446469002687 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469002688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469002689 active site 446469002690 phosphorylation site [posttranslational modification] 446469002691 intermolecular recognition site; other site 446469002692 dimerization interface [polypeptide binding]; other site 446469002693 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469002694 DNA binding site [nucleotide binding] 446469002695 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446469002696 Domain of unknown function DUF21; Region: DUF21; pfam01595 446469002697 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446469002698 Transporter associated domain; Region: CorC_HlyC; pfam03471 446469002699 Domain of unknown function DUF21; Region: DUF21; pfam01595 446469002700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446469002701 FOG: CBS domain [General function prediction only]; Region: COG0517 446469002702 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 446469002703 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 446469002704 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 446469002705 putative catalytic cysteine [active] 446469002706 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 446469002707 putative active site [active] 446469002708 metal binding site [ion binding]; metal-binding site 446469002709 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 446469002710 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446469002711 DNA binding site [nucleotide binding] 446469002712 active site 446469002713 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446469002714 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469002715 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 446469002716 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 446469002717 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446469002718 DNA binding site [nucleotide binding] 446469002719 active site 446469002720 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446469002721 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446469002722 active site 446469002723 metal binding site [ion binding]; metal-binding site 446469002724 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446469002725 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446469002726 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446469002727 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446469002728 DNA binding residues [nucleotide binding] 446469002729 H+ Antiporter protein; Region: 2A0121; TIGR00900 446469002730 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446469002731 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446469002732 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446469002733 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446469002734 FAD binding pocket [chemical binding]; other site 446469002735 FAD binding motif [chemical binding]; other site 446469002736 phosphate binding motif [ion binding]; other site 446469002737 NAD binding pocket [chemical binding]; other site 446469002738 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446469002739 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446469002740 intersubunit interface [polypeptide binding]; other site 446469002741 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446469002742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469002743 Coenzyme A binding pocket [chemical binding]; other site 446469002744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446469002745 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446469002746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469002747 DNA-binding site [nucleotide binding]; DNA binding site 446469002748 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446469002749 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 446469002750 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 446469002751 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 446469002752 active site 446469002753 HIGH motif; other site 446469002754 KMSK motif region; other site 446469002755 tRNA binding surface [nucleotide binding]; other site 446469002756 DALR anticodon binding domain; Region: DALR_1; smart00836 446469002757 anticodon binding site; other site 446469002758 diaminopimelate decarboxylase; Region: lysA; TIGR01048 446469002759 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 446469002760 active site 446469002761 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446469002762 substrate binding site [chemical binding]; other site 446469002763 catalytic residues [active] 446469002764 dimer interface [polypeptide binding]; other site 446469002765 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446469002766 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446469002767 intersubunit interface [polypeptide binding]; other site 446469002768 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446469002769 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469002770 ABC-ATPase subunit interface; other site 446469002771 dimer interface [polypeptide binding]; other site 446469002772 putative PBP binding regions; other site 446469002773 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 446469002774 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446469002775 Walker A/P-loop; other site 446469002776 ATP binding site [chemical binding]; other site 446469002777 Q-loop/lid; other site 446469002778 ABC transporter signature motif; other site 446469002779 Walker B; other site 446469002780 D-loop; other site 446469002781 H-loop/switch region; other site 446469002782 homoserine dehydrogenase; Provisional; Region: PRK06349 446469002783 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 446469002784 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 446469002785 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 446469002786 threonine synthase; Reviewed; Region: PRK06721 446469002787 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 446469002788 homodimer interface [polypeptide binding]; other site 446469002789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469002790 catalytic residue [active] 446469002791 homoserine kinase; Provisional; Region: PRK01212 446469002792 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 446469002793 Transcription termination factor [Transcription]; Region: Rho; COG1158 446469002794 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446469002795 RNA binding site [nucleotide binding]; other site 446469002796 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 446469002797 multimer interface [polypeptide binding]; other site 446469002798 Walker A motif; other site 446469002799 ATP binding site [chemical binding]; other site 446469002800 Walker B motif; other site 446469002801 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 446469002802 peptide chain release factor 1; Validated; Region: prfA; PRK00591 446469002803 This domain is found in peptide chain release factors; Region: PCRF; smart00937 446469002804 RF-1 domain; Region: RF-1; pfam00472 446469002805 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 446469002806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469002807 S-adenosylmethionine binding site [chemical binding]; other site 446469002808 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 446469002809 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 446469002810 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 446469002811 Mg++ binding site [ion binding]; other site 446469002812 putative catalytic motif [active] 446469002813 substrate binding site [chemical binding]; other site 446469002814 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 446469002815 ATP synthase subunit C; Region: ATP-synt_C; cl00466 446469002816 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 446469002817 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 446469002818 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 446469002819 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 446469002820 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 446469002821 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 446469002822 beta subunit interaction interface [polypeptide binding]; other site 446469002823 Walker A motif; other site 446469002824 ATP binding site [chemical binding]; other site 446469002825 Walker B motif; other site 446469002826 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446469002827 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 446469002828 core domain interface [polypeptide binding]; other site 446469002829 delta subunit interface [polypeptide binding]; other site 446469002830 epsilon subunit interface [polypeptide binding]; other site 446469002831 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 446469002832 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 446469002833 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 446469002834 alpha subunit interaction interface [polypeptide binding]; other site 446469002835 Walker A motif; other site 446469002836 ATP binding site [chemical binding]; other site 446469002837 Walker B motif; other site 446469002838 inhibitor binding site; inhibition site 446469002839 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446469002840 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 446469002841 gamma subunit interface [polypeptide binding]; other site 446469002842 epsilon subunit interface [polypeptide binding]; other site 446469002843 LBP interface [polypeptide binding]; other site 446469002844 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 446469002845 hypothetical protein; Provisional; Region: PRK03298 446469002846 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446469002847 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 446469002848 PKC phosphorylation site [posttranslational modification]; other site 446469002849 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446469002850 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446469002851 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469002852 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446469002853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469002854 dimer interface [polypeptide binding]; other site 446469002855 conserved gate region; other site 446469002856 ABC-ATPase subunit interface; other site 446469002857 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469002858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469002859 dimer interface [polypeptide binding]; other site 446469002860 conserved gate region; other site 446469002861 putative PBP binding loops; other site 446469002862 ABC-ATPase subunit interface; other site 446469002863 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469002864 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469002865 DNA binding site [nucleotide binding] 446469002866 domain linker motif; other site 446469002867 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469002868 dimerization interface [polypeptide binding]; other site 446469002869 ligand binding site [chemical binding]; other site 446469002870 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446469002871 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446469002872 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446469002873 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 446469002874 putative alpha-glucosidase; Provisional; Region: PRK10658 446469002875 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 446469002876 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 446469002877 active site 446469002878 homotrimer interface [polypeptide binding]; other site 446469002879 catalytic site [active] 446469002880 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 446469002881 dimerization interface [polypeptide binding]; other site 446469002882 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 446469002883 putative active cleft [active] 446469002884 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469002885 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446469002886 nucleotide binding site [chemical binding]; other site 446469002887 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 446469002888 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446469002889 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 446469002890 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 446469002891 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446469002892 beta-galactosidase; Region: BGL; TIGR03356 446469002893 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 446469002894 catalytic residues [active] 446469002895 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 446469002896 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 446469002897 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 446469002898 Class I ribonucleotide reductase; Region: RNR_I; cd01679 446469002899 active site 446469002900 dimer interface [polypeptide binding]; other site 446469002901 catalytic residues [active] 446469002902 effector binding site; other site 446469002903 R2 peptide binding site; other site 446469002904 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 446469002905 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 446469002906 dimer interface [polypeptide binding]; other site 446469002907 putative radical transfer pathway; other site 446469002908 diiron center [ion binding]; other site 446469002909 tyrosyl radical; other site 446469002910 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 446469002911 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446469002912 active site 446469002913 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446469002914 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446469002915 TAP-like protein; Region: Abhydrolase_4; pfam08386 446469002916 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 446469002917 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446469002918 glycogen branching enzyme; Provisional; Region: PRK05402 446469002919 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 446469002920 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 446469002921 active site 446469002922 catalytic site [active] 446469002923 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 446469002924 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 446469002925 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 446469002926 trehalose synthase; Region: treS_nterm; TIGR02456 446469002927 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 446469002928 active site 446469002929 catalytic site [active] 446469002930 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 446469002931 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 446469002932 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446469002933 active site 446469002934 homodimer interface [polypeptide binding]; other site 446469002935 catalytic site [active] 446469002936 acceptor binding site [chemical binding]; other site 446469002937 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 446469002938 putative homodimer interface [polypeptide binding]; other site 446469002939 putative active site pocket [active] 446469002940 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 446469002941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469002942 Coenzyme A binding pocket [chemical binding]; other site 446469002943 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446469002944 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 446469002945 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 446469002946 active site 446469002947 catalytic site [active] 446469002948 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 446469002949 Ligand binding site [chemical binding]; other site 446469002950 Electron transfer flavoprotein domain; Region: ETF; pfam01012 446469002951 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 446469002952 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446469002953 Ligand Binding Site [chemical binding]; other site 446469002954 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 446469002955 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 446469002956 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 446469002957 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446469002958 catalytic residue [active] 446469002959 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 446469002960 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 446469002961 Ligand Binding Site [chemical binding]; other site 446469002962 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 446469002963 enterobactin exporter EntS; Provisional; Region: PRK10489 446469002964 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 446469002965 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446469002966 Ligase N family; Region: LIGANc; smart00532 446469002967 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 446469002968 nucleotide binding pocket [chemical binding]; other site 446469002969 K-X-D-G motif; other site 446469002970 catalytic site [active] 446469002971 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 446469002972 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 446469002973 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 446469002974 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 446469002975 Dimer interface [polypeptide binding]; other site 446469002976 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469002977 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446469002978 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446469002979 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446469002980 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446469002981 Walker A/P-loop; other site 446469002982 ATP binding site [chemical binding]; other site 446469002983 Q-loop/lid; other site 446469002984 ABC transporter signature motif; other site 446469002985 Walker B; other site 446469002986 D-loop; other site 446469002987 H-loop/switch region; other site 446469002988 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446469002989 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446469002990 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446469002991 TM-ABC transporter signature motif; other site 446469002992 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446469002993 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 446469002994 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446469002995 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446469002996 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446469002997 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446469002998 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 446469002999 Metal-binding active site; metal-binding site 446469003000 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 446469003001 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 446469003002 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446469003003 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 446469003004 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 446469003005 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 446469003006 GatB domain; Region: GatB_Yqey; smart00845 446469003007 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446469003008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469003009 Coenzyme A binding pocket [chemical binding]; other site 446469003010 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 446469003011 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 446469003012 DNA photolyase; Region: DNA_photolyase; pfam00875 446469003013 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 446469003014 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 446469003015 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 446469003016 aromatic arch; other site 446469003017 DCoH dimer interaction site [polypeptide binding]; other site 446469003018 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 446469003019 DCoH tetramer interaction site [polypeptide binding]; other site 446469003020 substrate binding site [chemical binding]; other site 446469003021 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 446469003022 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446469003023 PYR/PP interface [polypeptide binding]; other site 446469003024 dimer interface [polypeptide binding]; other site 446469003025 TPP binding site [chemical binding]; other site 446469003026 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446469003027 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 446469003028 TPP-binding site [chemical binding]; other site 446469003029 dimer interface [polypeptide binding]; other site 446469003030 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 446469003031 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 446469003032 putative valine binding site [chemical binding]; other site 446469003033 dimer interface [polypeptide binding]; other site 446469003034 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 446469003035 ketol-acid reductoisomerase; Provisional; Region: PRK05479 446469003036 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 446469003037 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 446469003038 Domain of unknown function (DUF385); Region: DUF385; pfam04075 446469003039 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 446469003040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469003041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469003042 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446469003043 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446469003044 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 446469003045 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446469003046 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 446469003047 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 446469003048 tartrate dehydrogenase; Region: TTC; TIGR02089 446469003049 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 446469003050 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 446469003051 homodimer interface [polypeptide binding]; other site 446469003052 substrate-cofactor binding pocket; other site 446469003053 catalytic residue [active] 446469003054 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 446469003055 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 446469003056 active site 446469003057 catalytic residues [active] 446469003058 metal binding site [ion binding]; metal-binding site 446469003059 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 446469003060 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 446469003061 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 446469003062 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446469003063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469003064 non-specific DNA binding site [nucleotide binding]; other site 446469003065 salt bridge; other site 446469003066 sequence-specific DNA binding site [nucleotide binding]; other site 446469003067 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 446469003068 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446469003069 catalytic residue [active] 446469003070 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 446469003071 Predicted membrane protein [Function unknown]; Region: COG3463 446469003072 hypothetical protein; Provisional; Region: PRK11770 446469003073 Domain of unknown function (DUF307); Region: DUF307; pfam03733 446469003074 Domain of unknown function (DUF307); Region: DUF307; pfam03733 446469003075 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446469003076 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 446469003077 DNA binding residues [nucleotide binding] 446469003078 putative dimer interface [polypeptide binding]; other site 446469003079 short chain dehydrogenase; Validated; Region: PRK08264 446469003080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469003081 NAD(P) binding site [chemical binding]; other site 446469003082 active site 446469003083 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 446469003084 putative deacylase active site [active] 446469003085 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 446469003086 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469003087 ATP binding site [chemical binding]; other site 446469003088 putative Mg++ binding site [ion binding]; other site 446469003089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469003090 nucleotide binding region [chemical binding]; other site 446469003091 ATP-binding site [chemical binding]; other site 446469003092 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 446469003093 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 446469003094 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 446469003095 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469003096 MarR family; Region: MarR_2; pfam12802 446469003097 hypothetical protein; Provisional; Region: PRK07236 446469003098 hypothetical protein; Provisional; Region: PRK07588 446469003099 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469003100 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469003101 active site 446469003102 catalytic tetrad [active] 446469003103 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446469003104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469003105 S-adenosylmethionine binding site [chemical binding]; other site 446469003106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 446469003107 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 446469003108 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 446469003109 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 446469003110 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 446469003111 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 446469003112 HIGH motif; other site 446469003113 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 446469003114 active site 446469003115 KMSKS motif; other site 446469003116 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446469003117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469003118 motif II; other site 446469003119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446469003120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446469003121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446469003122 dimerization interface [polypeptide binding]; other site 446469003123 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 446469003124 TIGR03086 family protein; Region: TIGR03086 446469003125 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446469003126 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446469003127 Bacterial transcriptional regulator; Region: IclR; pfam01614 446469003128 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 446469003129 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 446469003130 substrate binding site [chemical binding]; other site 446469003131 ligand binding site [chemical binding]; other site 446469003132 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 446469003133 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 446469003134 substrate binding site [chemical binding]; other site 446469003135 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 446469003136 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 446469003137 hinge; other site 446469003138 active site 446469003139 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446469003140 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446469003141 putative acyl-acceptor binding pocket; other site 446469003142 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 446469003143 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 446469003144 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 446469003145 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 446469003146 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446469003147 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446469003148 catalytic residue [active] 446469003149 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 446469003150 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446469003151 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 446469003152 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 446469003153 thiamine monophosphate kinase; Provisional; Region: PRK05731 446469003154 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 446469003155 ATP binding site [chemical binding]; other site 446469003156 dimerization interface [polypeptide binding]; other site 446469003157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469003158 Coenzyme A binding pocket [chemical binding]; other site 446469003159 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 446469003160 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 446469003161 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 446469003162 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 446469003163 generic binding surface II; other site 446469003164 ssDNA binding site; other site 446469003165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469003166 ATP binding site [chemical binding]; other site 446469003167 putative Mg++ binding site [ion binding]; other site 446469003168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469003169 nucleotide binding region [chemical binding]; other site 446469003170 ATP-binding site [chemical binding]; other site 446469003171 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 446469003172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469003173 S-adenosylmethionine binding site [chemical binding]; other site 446469003174 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 446469003175 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 446469003176 active site 446469003177 (T/H)XGH motif; other site 446469003178 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 446469003179 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 446469003180 ribonuclease III; Reviewed; Region: rnc; PRK00102 446469003181 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 446469003182 dimerization interface [polypeptide binding]; other site 446469003183 active site 446469003184 metal binding site [ion binding]; metal-binding site 446469003185 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 446469003186 dsRNA binding site [nucleotide binding]; other site 446469003187 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 446469003188 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 446469003189 DNA binding site [nucleotide binding] 446469003190 catalytic residue [active] 446469003191 H2TH interface [polypeptide binding]; other site 446469003192 putative catalytic residues [active] 446469003193 turnover-facilitating residue; other site 446469003194 intercalation triad [nucleotide binding]; other site 446469003195 8OG recognition residue [nucleotide binding]; other site 446469003196 putative reading head residues; other site 446469003197 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446469003198 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446469003199 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 446469003200 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_3; cd12160 446469003201 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446469003202 putative ligand binding site [chemical binding]; other site 446469003203 putative NAD binding site [chemical binding]; other site 446469003204 catalytic site [active] 446469003205 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469003206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469003207 active site 446469003208 phosphorylation site [posttranslational modification] 446469003209 intermolecular recognition site; other site 446469003210 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469003211 DNA binding residues [nucleotide binding] 446469003212 dimerization interface [polypeptide binding]; other site 446469003213 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446469003214 GAF domain; Region: GAF_3; pfam13492 446469003215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446469003216 Histidine kinase; Region: HisKA_3; pfam07730 446469003217 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 446469003218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469003219 Walker A/P-loop; other site 446469003220 ATP binding site [chemical binding]; other site 446469003221 Q-loop/lid; other site 446469003222 ABC transporter signature motif; other site 446469003223 Walker B; other site 446469003224 D-loop; other site 446469003225 H-loop/switch region; other site 446469003226 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469003227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469003228 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 446469003229 Walker A/P-loop; other site 446469003230 ATP binding site [chemical binding]; other site 446469003231 Q-loop/lid; other site 446469003232 ABC transporter signature motif; other site 446469003233 Walker B; other site 446469003234 D-loop; other site 446469003235 H-loop/switch region; other site 446469003236 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446469003237 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 446469003238 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 446469003239 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 446469003240 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 446469003241 homodimer interface [polypeptide binding]; other site 446469003242 oligonucleotide binding site [chemical binding]; other site 446469003243 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 446469003244 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 446469003245 GTPase CgtA; Reviewed; Region: obgE; PRK12296 446469003246 GTP1/OBG; Region: GTP1_OBG; pfam01018 446469003247 Obg GTPase; Region: Obg; cd01898 446469003248 G1 box; other site 446469003249 GTP/Mg2+ binding site [chemical binding]; other site 446469003250 Switch I region; other site 446469003251 G2 box; other site 446469003252 G3 box; other site 446469003253 Switch II region; other site 446469003254 G4 box; other site 446469003255 G5 box; other site 446469003256 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 446469003257 gamma-glutamyl kinase; Provisional; Region: PRK05429 446469003258 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 446469003259 nucleotide binding site [chemical binding]; other site 446469003260 homotetrameric interface [polypeptide binding]; other site 446469003261 putative phosphate binding site [ion binding]; other site 446469003262 putative allosteric binding site; other site 446469003263 PUA domain; Region: PUA; pfam01472 446469003264 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 446469003265 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 446469003266 putative catalytic cysteine [active] 446469003267 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 446469003268 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 446469003269 active site 446469003270 (T/H)XGH motif; other site 446469003271 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 446469003272 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446469003273 catalytic core [active] 446469003274 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446469003275 Amidase; Region: Amidase; cl11426 446469003276 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 446469003277 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446469003278 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469003279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469003280 DNA binding site [nucleotide binding] 446469003281 domain linker motif; other site 446469003282 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446469003283 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469003284 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469003285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469003286 dimer interface [polypeptide binding]; other site 446469003287 conserved gate region; other site 446469003288 putative PBP binding loops; other site 446469003289 ABC-ATPase subunit interface; other site 446469003290 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469003291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469003292 dimer interface [polypeptide binding]; other site 446469003293 conserved gate region; other site 446469003294 putative PBP binding loops; other site 446469003295 ABC-ATPase subunit interface; other site 446469003296 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 446469003297 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446469003298 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446469003299 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469003300 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469003301 DNA binding site [nucleotide binding] 446469003302 domain linker motif; other site 446469003303 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469003304 ligand binding site [chemical binding]; other site 446469003305 dimerization interface [polypeptide binding]; other site 446469003306 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469003307 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469003308 DNA binding site [nucleotide binding] 446469003309 domain linker motif; other site 446469003310 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446469003311 ligand binding site [chemical binding]; other site 446469003312 dimerization interface (open form) [polypeptide binding]; other site 446469003313 dimerization interface (closed form) [polypeptide binding]; other site 446469003314 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469003315 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469003316 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446469003317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469003318 dimer interface [polypeptide binding]; other site 446469003319 conserved gate region; other site 446469003320 putative PBP binding loops; other site 446469003321 ABC-ATPase subunit interface; other site 446469003322 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469003323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469003324 dimer interface [polypeptide binding]; other site 446469003325 conserved gate region; other site 446469003326 putative PBP binding loops; other site 446469003327 ABC-ATPase subunit interface; other site 446469003328 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446469003329 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446469003330 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446469003331 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446469003332 active site 446469003333 putative acetyltransferase; Provisional; Region: PRK03624 446469003334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469003335 Coenzyme A binding pocket [chemical binding]; other site 446469003336 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446469003337 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446469003338 active site 446469003339 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446469003340 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469003341 DNA-binding site [nucleotide binding]; DNA binding site 446469003342 FCD domain; Region: FCD; pfam07729 446469003343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469003344 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469003345 putative substrate translocation pore; other site 446469003346 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 446469003347 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446469003348 substrate binding pocket [chemical binding]; other site 446469003349 catalytic triad [active] 446469003350 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 446469003351 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 446469003352 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 446469003353 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 446469003354 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 446469003355 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 446469003356 Protein of unknown function (DUF461); Region: DUF461; pfam04314 446469003357 CopC domain; Region: CopC; pfam04234 446469003358 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 446469003359 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 446469003360 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 446469003361 putative anticodon binding site; other site 446469003362 dimer interface [polypeptide binding]; other site 446469003363 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446469003364 motif 1; other site 446469003365 dimer interface [polypeptide binding]; other site 446469003366 active site 446469003367 motif 2; other site 446469003368 motif 3; other site 446469003369 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 446469003370 PAS domain; Region: PAS_9; pfam13426 446469003371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446469003372 putative active site [active] 446469003373 heme pocket [chemical binding]; other site 446469003374 PAS fold; Region: PAS_4; pfam08448 446469003375 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446469003376 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469003377 dimerization interface [polypeptide binding]; other site 446469003378 putative DNA binding site [nucleotide binding]; other site 446469003379 putative Zn2+ binding site [ion binding]; other site 446469003380 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 446469003381 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446469003382 Soluble P-type ATPase [General function prediction only]; Region: COG4087 446469003383 Thioredoxin; Region: Thioredoxin_4; pfam13462 446469003384 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 446469003385 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 446469003386 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 446469003387 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469003388 MarR family; Region: MarR_2; pfam12802 446469003389 CGNR zinc finger; Region: zf-CGNR; pfam11706 446469003390 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 446469003391 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 446469003392 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446469003393 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446469003394 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469003395 MarR family; Region: MarR_2; pfam12802 446469003396 MarR family; Region: MarR_2; cl17246 446469003397 GAF domain; Region: GAF; pfam01590 446469003398 GAF domain; Region: GAF_2; pfam13185 446469003399 ANTAR domain; Region: ANTAR; pfam03861 446469003400 PAS fold; Region: PAS_3; pfam08447 446469003401 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 446469003402 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 446469003403 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 446469003404 dimanganese center [ion binding]; other site 446469003405 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 446469003406 Y-family of DNA polymerases; Region: PolY; cl12025 446469003407 active site 446469003408 DNA binding site [nucleotide binding] 446469003409 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469003410 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469003411 active site 446469003412 catalytic tetrad [active] 446469003413 maltose O-acetyltransferase; Provisional; Region: PRK10092 446469003414 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 446469003415 trimer interface [polypeptide binding]; other site 446469003416 active site 446469003417 substrate binding site [chemical binding]; other site 446469003418 CoA binding site [chemical binding]; other site 446469003419 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446469003420 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446469003421 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 446469003422 NADP binding site [chemical binding]; other site 446469003423 active site 446469003424 steroid binding site; other site 446469003425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469003426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469003427 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 446469003428 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446469003429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469003430 Coenzyme A binding pocket [chemical binding]; other site 446469003431 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446469003432 UTRA domain; Region: UTRA; cl17743 446469003433 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446469003434 Coenzyme A binding pocket [chemical binding]; other site 446469003435 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446469003436 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469003437 Walker A/P-loop; other site 446469003438 ATP binding site [chemical binding]; other site 446469003439 Q-loop/lid; other site 446469003440 ABC transporter signature motif; other site 446469003441 Walker B; other site 446469003442 D-loop; other site 446469003443 H-loop/switch region; other site 446469003444 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469003445 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469003446 Walker A/P-loop; other site 446469003447 ATP binding site [chemical binding]; other site 446469003448 Q-loop/lid; other site 446469003449 ABC transporter signature motif; other site 446469003450 Walker B; other site 446469003451 D-loop; other site 446469003452 H-loop/switch region; other site 446469003453 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446469003454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469003455 putative PBP binding loops; other site 446469003456 ABC-ATPase subunit interface; other site 446469003457 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446469003458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469003459 dimer interface [polypeptide binding]; other site 446469003460 conserved gate region; other site 446469003461 putative PBP binding loops; other site 446469003462 ABC-ATPase subunit interface; other site 446469003463 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 446469003464 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446469003465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469003466 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 446469003467 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 446469003468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469003469 S-adenosylmethionine binding site [chemical binding]; other site 446469003470 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 446469003471 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 446469003472 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 446469003473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469003474 NAD(P) binding site [chemical binding]; other site 446469003475 active site 446469003476 Predicted transcriptional regulators [Transcription]; Region: COG1733 446469003477 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469003478 putative DNA binding site [nucleotide binding]; other site 446469003479 dimerization interface [polypeptide binding]; other site 446469003480 putative Zn2+ binding site [ion binding]; other site 446469003481 Domain of unknown function (DUF336); Region: DUF336; cl01249 446469003482 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 446469003483 nudix motif; other site 446469003484 AzlC protein; Region: AzlC; cl00570 446469003485 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 446469003486 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446469003487 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446469003488 Uncharacterized conserved protein [Function unknown]; Region: COG1359 446469003489 Cupin; Region: Cupin_6; pfam12852 446469003490 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446469003491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446469003492 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 446469003493 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 446469003494 metal binding site [ion binding]; metal-binding site 446469003495 dimer interface [polypeptide binding]; other site 446469003496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 446469003497 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446469003498 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 446469003499 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469003500 MarR family; Region: MarR_2; pfam12802 446469003501 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446469003502 classical (c) SDRs; Region: SDR_c; cd05233 446469003503 NAD(P) binding site [chemical binding]; other site 446469003504 active site 446469003505 Protein of unknown function (DUF419); Region: DUF419; cl15265 446469003506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 446469003507 Chloramphenicol acetyltransferase; Region: CAT; cl02008 446469003508 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 446469003509 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446469003510 Carboxylesterase family; Region: COesterase; pfam00135 446469003511 substrate binding pocket [chemical binding]; other site 446469003512 catalytic triad [active] 446469003513 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 446469003514 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446469003515 Protein of unknown function, DUF606; Region: DUF606; pfam04657 446469003516 Protein of unknown function, DUF606; Region: DUF606; pfam04657 446469003517 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 446469003518 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446469003519 stage V sporulation protein K; Region: spore_V_K; TIGR02881 446469003520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469003521 Walker A motif; other site 446469003522 ATP binding site [chemical binding]; other site 446469003523 Walker B motif; other site 446469003524 arginine finger; other site 446469003525 hypothetical protein; Provisional; Region: PRK04233 446469003526 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446469003527 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446469003528 active site 446469003529 Tetratrico peptide repeat; Region: TPR_5; pfam12688 446469003530 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 446469003531 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 446469003532 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 446469003533 oligomerization interface [polypeptide binding]; other site 446469003534 active site 446469003535 metal binding site [ion binding]; metal-binding site 446469003536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446469003537 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446469003538 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446469003539 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446469003540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446469003541 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 446469003542 putative active site; other site 446469003543 putative metal binding residues [ion binding]; other site 446469003544 signature motif; other site 446469003545 putative triphosphate binding site [ion binding]; other site 446469003546 putative hydrolase; Provisional; Region: PRK11460 446469003547 Predicted esterase [General function prediction only]; Region: COG0400 446469003548 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469003549 MarR family; Region: MarR_2; cl17246 446469003550 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 446469003551 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 446469003552 active site 446469003553 metal binding site [ion binding]; metal-binding site 446469003554 nudix motif; other site 446469003555 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446469003556 substrate binding pocket [chemical binding]; other site 446469003557 chain length determination region; other site 446469003558 substrate-Mg2+ binding site; other site 446469003559 catalytic residues [active] 446469003560 aspartate-rich region 1; other site 446469003561 active site lid residues [active] 446469003562 aspartate-rich region 2; other site 446469003563 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 446469003564 active site lid residues [active] 446469003565 substrate binding pocket [chemical binding]; other site 446469003566 catalytic residues [active] 446469003567 substrate-Mg2+ binding site; other site 446469003568 aspartate-rich region 1; other site 446469003569 aspartate-rich region 2; other site 446469003570 phytoene desaturase; Region: crtI_fam; TIGR02734 446469003571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446469003572 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 446469003573 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 446469003574 prenyltransferase; Reviewed; Region: ubiA; PRK13105 446469003575 UbiA prenyltransferase family; Region: UbiA; pfam01040 446469003576 Predicted membrane protein [Function unknown]; Region: COG2860 446469003577 UPF0126 domain; Region: UPF0126; pfam03458 446469003578 UPF0126 domain; Region: UPF0126; pfam03458 446469003579 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 446469003580 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 446469003581 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446469003582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469003583 Walker A/P-loop; other site 446469003584 ATP binding site [chemical binding]; other site 446469003585 Q-loop/lid; other site 446469003586 ABC transporter signature motif; other site 446469003587 Walker B; other site 446469003588 D-loop; other site 446469003589 H-loop/switch region; other site 446469003590 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469003591 dimerization interface [polypeptide binding]; other site 446469003592 putative DNA binding site [nucleotide binding]; other site 446469003593 putative Zn2+ binding site [ion binding]; other site 446469003594 Peptidase family M23; Region: Peptidase_M23; pfam01551 446469003595 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446469003596 thymidine kinase; Provisional; Region: PRK04296 446469003597 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 446469003598 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469003599 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469003600 active site 446469003601 catalytic tetrad [active] 446469003602 Predicted transcriptional regulators [Transcription]; Region: COG1695 446469003603 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446469003604 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 446469003605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469003606 Coenzyme A binding pocket [chemical binding]; other site 446469003607 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446469003608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469003609 Coenzyme A binding pocket [chemical binding]; other site 446469003610 malate:quinone oxidoreductase; Validated; Region: PRK05257 446469003611 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 446469003612 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 446469003613 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 446469003614 putative metal binding residues [ion binding]; other site 446469003615 signature motif; other site 446469003616 dimer interface [polypeptide binding]; other site 446469003617 active site 446469003618 polyP binding site; other site 446469003619 substrate binding site [chemical binding]; other site 446469003620 acceptor-phosphate pocket; other site 446469003621 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 446469003622 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 446469003623 nucleotide binding site [chemical binding]; other site 446469003624 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 446469003625 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 446469003626 active site 446469003627 DNA binding site [nucleotide binding] 446469003628 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 446469003629 DNA binding site [nucleotide binding] 446469003630 AAA ATPase domain; Region: AAA_16; pfam13191 446469003631 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 446469003632 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 446469003633 putative DNA binding site [nucleotide binding]; other site 446469003634 putative homodimer interface [polypeptide binding]; other site 446469003635 GAF domain; Region: GAF_2; pfam13185 446469003636 GAF domain; Region: GAF_3; pfam13492 446469003637 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446469003638 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 446469003639 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446469003640 anti sigma factor interaction site; other site 446469003641 regulatory phosphorylation site [posttranslational modification]; other site 446469003642 PAS fold; Region: PAS_2; pfam08446 446469003643 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446469003644 GAF domain; Region: GAF; pfam01590 446469003645 Phytochrome region; Region: PHY; pfam00360 446469003646 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446469003647 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 446469003648 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 446469003649 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 446469003650 Lsr2; Region: Lsr2; pfam11774 446469003651 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446469003652 active site 446469003653 metal binding site [ion binding]; metal-binding site 446469003654 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 446469003655 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 446469003656 metal binding site [ion binding]; metal-binding site 446469003657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469003658 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 446469003659 Walker A/P-loop; other site 446469003660 ATP binding site [chemical binding]; other site 446469003661 Q-loop/lid; other site 446469003662 ABC transporter signature motif; other site 446469003663 Walker B; other site 446469003664 D-loop; other site 446469003665 H-loop/switch region; other site 446469003666 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 446469003667 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469003668 ABC-ATPase subunit interface; other site 446469003669 dimer interface [polypeptide binding]; other site 446469003670 putative PBP binding regions; other site 446469003671 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 446469003672 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 446469003673 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 446469003674 FeoA domain; Region: FeoA; pfam04023 446469003675 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446469003676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469003677 putative substrate translocation pore; other site 446469003678 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 446469003679 putative active site [active] 446469003680 redox center [active] 446469003681 aminoacyl-tRNA ligase; Region: PLN02563 446469003682 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446469003683 active site 446469003684 HIGH motif; other site 446469003685 nucleotide binding site [chemical binding]; other site 446469003686 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446469003687 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 446469003688 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446469003689 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446469003690 active site 446469003691 KMSKS motif; other site 446469003692 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 446469003693 tRNA binding surface [nucleotide binding]; other site 446469003694 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 446469003695 SLBB domain; Region: SLBB; pfam10531 446469003696 comEA protein; Region: comE; TIGR01259 446469003697 Helix-hairpin-helix motif; Region: HHH; pfam00633 446469003698 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 446469003699 Competence protein; Region: Competence; pfam03772 446469003700 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 446469003701 hypothetical protein; Reviewed; Region: PRK07914 446469003702 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 446469003703 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446469003704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469003705 non-specific DNA binding site [nucleotide binding]; other site 446469003706 salt bridge; other site 446469003707 sequence-specific DNA binding site [nucleotide binding]; other site 446469003708 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 446469003709 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 446469003710 putative active site [active] 446469003711 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 446469003712 PemK-like protein; Region: PemK; cl00995 446469003713 Protein of unknown function, DUF485; Region: DUF485; pfam04341 446469003714 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 446469003715 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 446469003716 Na binding site [ion binding]; other site 446469003717 GTP-binding protein LepA; Provisional; Region: PRK05433 446469003718 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 446469003719 G1 box; other site 446469003720 putative GEF interaction site [polypeptide binding]; other site 446469003721 GTP/Mg2+ binding site [chemical binding]; other site 446469003722 Switch I region; other site 446469003723 G2 box; other site 446469003724 G3 box; other site 446469003725 Switch II region; other site 446469003726 G4 box; other site 446469003727 G5 box; other site 446469003728 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 446469003729 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 446469003730 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 446469003731 coproporphyrinogen III oxidase; Validated; Region: PRK05628 446469003732 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446469003733 FeS/SAM binding site; other site 446469003734 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446469003735 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 446469003736 catalytic triad [active] 446469003737 catalytic triad [active] 446469003738 oxyanion hole [active] 446469003739 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 446469003740 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 446469003741 Protein of unknown function (DUF779); Region: DUF779; pfam05610 446469003742 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 446469003743 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446469003744 NAD(P) binding site [chemical binding]; other site 446469003745 catalytic residues [active] 446469003746 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446469003747 DNA binding site [nucleotide binding] 446469003748 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 446469003749 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 446469003750 chaperone protein DnaJ; Provisional; Region: PRK14278 446469003751 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446469003752 HSP70 interaction site [polypeptide binding]; other site 446469003753 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 446469003754 Zn binding sites [ion binding]; other site 446469003755 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 446469003756 dimer interface [polypeptide binding]; other site 446469003757 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 446469003758 RNA methyltransferase, RsmE family; Region: TIGR00046 446469003759 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 446469003760 nucleotide binding site/active site [active] 446469003761 HIT family signature motif; other site 446469003762 catalytic residue [active] 446469003763 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 446469003764 PhoH-like protein; Region: PhoH; pfam02562 446469003765 metal-binding heat shock protein; Provisional; Region: PRK00016 446469003766 Domain of unknown function DUF21; Region: DUF21; pfam01595 446469003767 FOG: CBS domain [General function prediction only]; Region: COG0517 446469003768 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446469003769 Transporter associated domain; Region: CorC_HlyC; smart01091 446469003770 GTPase Era; Reviewed; Region: era; PRK00089 446469003771 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 446469003772 G1 box; other site 446469003773 GTP/Mg2+ binding site [chemical binding]; other site 446469003774 Switch I region; other site 446469003775 G2 box; other site 446469003776 Switch II region; other site 446469003777 G3 box; other site 446469003778 G4 box; other site 446469003779 G5 box; other site 446469003780 KH domain; Region: KH_2; pfam07650 446469003781 2-isopropylmalate synthase; Validated; Region: PRK03739 446469003782 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 446469003783 active site 446469003784 catalytic residues [active] 446469003785 metal binding site [ion binding]; metal-binding site 446469003786 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 446469003787 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 446469003788 Recombination protein O N terminal; Region: RecO_N; pfam11967 446469003789 Recombination protein O C terminal; Region: RecO_C; pfam02565 446469003790 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 446469003791 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 446469003792 catalytic residue [active] 446469003793 putative FPP diphosphate binding site; other site 446469003794 putative FPP binding hydrophobic cleft; other site 446469003795 dimer interface [polypeptide binding]; other site 446469003796 putative IPP diphosphate binding site; other site 446469003797 Part of AAA domain; Region: AAA_19; pfam13245 446469003798 Family description; Region: UvrD_C_2; pfam13538 446469003799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469003800 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469003801 dimerization interface [polypeptide binding]; other site 446469003802 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469003803 dimer interface [polypeptide binding]; other site 446469003804 phosphorylation site [posttranslational modification] 446469003805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469003806 ATP binding site [chemical binding]; other site 446469003807 Mg2+ binding site [ion binding]; other site 446469003808 G-X-G motif; other site 446469003809 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469003810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469003811 active site 446469003812 phosphorylation site [posttranslational modification] 446469003813 intermolecular recognition site; other site 446469003814 dimerization interface [polypeptide binding]; other site 446469003815 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469003816 DNA binding site [nucleotide binding] 446469003817 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446469003818 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446469003819 Walker A/P-loop; other site 446469003820 ATP binding site [chemical binding]; other site 446469003821 Q-loop/lid; other site 446469003822 ABC transporter signature motif; other site 446469003823 Walker B; other site 446469003824 D-loop; other site 446469003825 H-loop/switch region; other site 446469003826 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446469003827 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446469003828 FtsX-like permease family; Region: FtsX; pfam02687 446469003829 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446469003830 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446469003831 metal binding site 2 [ion binding]; metal-binding site 446469003832 putative DNA binding helix; other site 446469003833 metal binding site 1 [ion binding]; metal-binding site 446469003834 dimer interface [polypeptide binding]; other site 446469003835 structural Zn2+ binding site [ion binding]; other site 446469003836 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 446469003837 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469003838 ABC-ATPase subunit interface; other site 446469003839 dimer interface [polypeptide binding]; other site 446469003840 putative PBP binding regions; other site 446469003841 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446469003842 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 446469003843 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 446469003844 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 446469003845 metal binding site [ion binding]; metal-binding site 446469003846 aminotransferase; Validated; Region: PRK07777 446469003847 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446469003848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469003849 homodimer interface [polypeptide binding]; other site 446469003850 catalytic residue [active] 446469003851 glycyl-tRNA synthetase; Provisional; Region: PRK04173 446469003852 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446469003853 motif 1; other site 446469003854 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 446469003855 active site 446469003856 motif 2; other site 446469003857 motif 3; other site 446469003858 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 446469003859 anticodon binding site; other site 446469003860 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446469003861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469003862 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446469003863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469003864 putative substrate translocation pore; other site 446469003865 Putative esterase; Region: Esterase; pfam00756 446469003866 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 446469003867 AMIN domain; Region: AMIN; pfam11741 446469003868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446469003869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469003870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446469003871 Coenzyme A binding pocket [chemical binding]; other site 446469003872 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 446469003873 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 446469003874 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446469003875 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446469003876 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446469003877 DNA binding residues [nucleotide binding] 446469003878 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 446469003879 homotrimer interaction site [polypeptide binding]; other site 446469003880 putative active site [active] 446469003881 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 446469003882 putative dimer interface [polypeptide binding]; other site 446469003883 putative [2Fe-2S] cluster binding site [ion binding]; other site 446469003884 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 446469003885 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 446469003886 FMN binding site [chemical binding]; other site 446469003887 active site 446469003888 catalytic residues [active] 446469003889 substrate binding site [chemical binding]; other site 446469003890 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 446469003891 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 446469003892 active site 446469003893 catalytic site [active] 446469003894 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469003895 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469003896 DNA binding site [nucleotide binding] 446469003897 domain linker motif; other site 446469003898 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 446469003899 putative dimerization interface [polypeptide binding]; other site 446469003900 putative ligand binding site [chemical binding]; other site 446469003901 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 446469003902 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469003903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469003904 dimer interface [polypeptide binding]; other site 446469003905 conserved gate region; other site 446469003906 putative PBP binding loops; other site 446469003907 ABC-ATPase subunit interface; other site 446469003908 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469003909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469003910 dimer interface [polypeptide binding]; other site 446469003911 conserved gate region; other site 446469003912 putative PBP binding loops; other site 446469003913 ABC-ATPase subunit interface; other site 446469003914 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 446469003915 homodimer interface [polypeptide binding]; other site 446469003916 maltodextrin glucosidase; Provisional; Region: PRK10785 446469003917 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 446469003918 active site 446469003919 homodimer interface [polypeptide binding]; other site 446469003920 catalytic site [active] 446469003921 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 446469003922 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446469003923 Zn2+ binding site [ion binding]; other site 446469003924 Mg2+ binding site [ion binding]; other site 446469003925 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 446469003926 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446469003927 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469003928 DNA binding residues [nucleotide binding] 446469003929 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446469003930 nudix motif; other site 446469003931 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 446469003932 catalytic nucleophile [active] 446469003933 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446469003934 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446469003935 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446469003936 FO synthase; Reviewed; Region: fbiC; PRK09234 446469003937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446469003938 FeS/SAM binding site; other site 446469003939 DNA primase; Validated; Region: dnaG; PRK05667 446469003940 CHC2 zinc finger; Region: zf-CHC2; pfam01807 446469003941 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 446469003942 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 446469003943 active site 446469003944 metal binding site [ion binding]; metal-binding site 446469003945 interdomain interaction site; other site 446469003946 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 446469003947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469003948 S-adenosylmethionine binding site [chemical binding]; other site 446469003949 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446469003950 active site 446469003951 catalytic residues [active] 446469003952 metal binding site [ion binding]; metal-binding site 446469003953 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 446469003954 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446469003955 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446469003956 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 446469003957 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 446469003958 dimer interface [polypeptide binding]; other site 446469003959 active site 446469003960 acyl carrier protein; Provisional; Region: acpP; PRK00982 446469003961 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 446469003962 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 446469003963 dimer interface [polypeptide binding]; other site 446469003964 active site 446469003965 CoA binding pocket [chemical binding]; other site 446469003966 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 446469003967 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446469003968 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446469003969 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 446469003970 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 446469003971 dimer interface [polypeptide binding]; other site 446469003972 TPP-binding site [chemical binding]; other site 446469003973 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 446469003974 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 446469003975 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446469003976 dimer interface [polypeptide binding]; other site 446469003977 catalytic triad [active] 446469003978 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 446469003979 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446469003980 classical (c) SDRs; Region: SDR_c; cd05233 446469003981 NAD(P) binding site [chemical binding]; other site 446469003982 active site 446469003983 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 446469003984 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469003985 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469003986 active site 446469003987 catalytic tetrad [active] 446469003988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 446469003989 salt bridge; other site 446469003990 non-specific DNA binding site [nucleotide binding]; other site 446469003991 sequence-specific DNA binding site [nucleotide binding]; other site 446469003992 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 446469003993 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 446469003994 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 446469003995 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469003996 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469003997 DNA binding site [nucleotide binding] 446469003998 domain linker motif; other site 446469003999 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446469004000 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446469004001 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469004002 Walker A/P-loop; other site 446469004003 ATP binding site [chemical binding]; other site 446469004004 Q-loop/lid; other site 446469004005 ABC transporter signature motif; other site 446469004006 Walker B; other site 446469004007 D-loop; other site 446469004008 H-loop/switch region; other site 446469004009 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469004010 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469004011 Walker A/P-loop; other site 446469004012 ATP binding site [chemical binding]; other site 446469004013 Q-loop/lid; other site 446469004014 ABC transporter signature motif; other site 446469004015 Walker B; other site 446469004016 D-loop; other site 446469004017 H-loop/switch region; other site 446469004018 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446469004019 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446469004020 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 446469004021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469004022 dimer interface [polypeptide binding]; other site 446469004023 conserved gate region; other site 446469004024 putative PBP binding loops; other site 446469004025 ABC-ATPase subunit interface; other site 446469004026 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446469004027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469004028 dimer interface [polypeptide binding]; other site 446469004029 conserved gate region; other site 446469004030 putative PBP binding loops; other site 446469004031 ABC-ATPase subunit interface; other site 446469004032 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446469004033 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 446469004034 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446469004035 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 446469004036 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 446469004037 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 446469004038 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 446469004039 hypothetical protein; Provisional; Region: PRK07758 446469004040 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469004041 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469004042 active site 446469004043 catalytic tetrad [active] 446469004044 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 446469004045 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469004046 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469004047 active site 446469004048 catalytic tetrad [active] 446469004049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469004050 salt bridge; other site 446469004051 non-specific DNA binding site [nucleotide binding]; other site 446469004052 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446469004053 sequence-specific DNA binding site [nucleotide binding]; other site 446469004054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 446469004055 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 446469004056 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446469004057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469004058 enoyl_reductase_like; Region: enoyl_reductase_like; cd08249 446469004059 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446469004060 NAD(P) binding site [chemical binding]; other site 446469004061 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 446469004062 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 446469004063 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 446469004064 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446469004065 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446469004066 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446469004067 active site 446469004068 shikimate kinase; Reviewed; Region: aroK; PRK00131 446469004069 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 446469004070 RibD C-terminal domain; Region: RibD_C; cl17279 446469004071 O-methyltransferase; Region: Methyltransf_2; pfam00891 446469004072 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446469004073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469004074 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 446469004075 Walker A/P-loop; other site 446469004076 ATP binding site [chemical binding]; other site 446469004077 Q-loop/lid; other site 446469004078 ABC transporter signature motif; other site 446469004079 Walker B; other site 446469004080 D-loop; other site 446469004081 H-loop/switch region; other site 446469004082 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 446469004083 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 446469004084 Asparagine synthase; Region: Asn_synthase; pfam00733 446469004085 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446469004086 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 446469004087 active site 446469004088 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 446469004089 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 446469004090 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 446469004091 Predicted membrane protein [Function unknown]; Region: COG2311 446469004092 Protein of unknown function (DUF418); Region: DUF418; cl12135 446469004093 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446469004094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469004095 RibD C-terminal domain; Region: RibD_C; cl17279 446469004096 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446469004097 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446469004098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469004099 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469004100 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469004101 active site 446469004102 catalytic tetrad [active] 446469004103 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469004104 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469004105 active site 446469004106 catalytic tetrad [active] 446469004107 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469004108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469004109 putative substrate translocation pore; other site 446469004110 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 446469004111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446469004112 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 446469004113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446469004114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446469004115 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446469004116 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446469004117 active site 446469004118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469004119 dimerization interface [polypeptide binding]; other site 446469004120 putative DNA binding site [nucleotide binding]; other site 446469004121 putative Zn2+ binding site [ion binding]; other site 446469004122 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446469004123 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446469004124 active site 446469004125 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 446469004126 arsenical-resistance protein; Region: acr3; TIGR00832 446469004127 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 446469004128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469004129 putative DNA binding site [nucleotide binding]; other site 446469004130 dimerization interface [polypeptide binding]; other site 446469004131 putative Zn2+ binding site [ion binding]; other site 446469004132 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 446469004133 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446469004134 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446469004135 DNA binding residues [nucleotide binding] 446469004136 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446469004137 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446469004138 intersubunit interface [polypeptide binding]; other site 446469004139 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446469004140 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446469004141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469004142 putative substrate translocation pore; other site 446469004143 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469004144 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469004145 DNA binding site [nucleotide binding] 446469004146 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469004147 dimerization interface [polypeptide binding]; other site 446469004148 ligand binding site [chemical binding]; other site 446469004149 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469004150 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469004151 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 446469004152 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469004153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469004154 dimer interface [polypeptide binding]; other site 446469004155 conserved gate region; other site 446469004156 putative PBP binding loops; other site 446469004157 ABC-ATPase subunit interface; other site 446469004158 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 446469004159 active site 446469004160 catalytic site [active] 446469004161 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 446469004162 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 446469004163 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446469004164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469004165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469004166 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 446469004167 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 446469004168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469004169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469004170 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446469004171 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 446469004172 RDD family; Region: RDD; pfam06271 446469004173 RDD family; Region: RDD; pfam06271 446469004174 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 446469004175 Uncharacterized conserved protein [Function unknown]; Region: COG0327 446469004176 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 446469004177 Putative zinc ribbon domain; Region: DUF164; pfam02591 446469004178 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446469004179 catalytic core [active] 446469004180 Phosphotransferase enzyme family; Region: APH; pfam01636 446469004181 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446469004182 active site 446469004183 ATP binding site [chemical binding]; other site 446469004184 substrate binding site [chemical binding]; other site 446469004185 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 446469004186 hypothetical protein; Validated; Region: PRK02101 446469004187 Protein of unknown function (DUF466); Region: DUF466; cl01082 446469004188 carbon starvation protein A; Provisional; Region: PRK15015 446469004189 Carbon starvation protein CstA; Region: CstA; pfam02554 446469004190 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 446469004191 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446469004192 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446469004193 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446469004194 dimer interface [polypeptide binding]; other site 446469004195 ADP-ribose binding site [chemical binding]; other site 446469004196 active site 446469004197 nudix motif; other site 446469004198 metal binding site [ion binding]; metal-binding site 446469004199 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 446469004200 active site 1 [active] 446469004201 dimer interface [polypeptide binding]; other site 446469004202 hexamer interface [polypeptide binding]; other site 446469004203 active site 2 [active] 446469004204 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469004205 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469004206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469004207 dimer interface [polypeptide binding]; other site 446469004208 conserved gate region; other site 446469004209 putative PBP binding loops; other site 446469004210 ABC-ATPase subunit interface; other site 446469004211 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469004212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469004213 dimer interface [polypeptide binding]; other site 446469004214 conserved gate region; other site 446469004215 putative PBP binding loops; other site 446469004216 ABC-ATPase subunit interface; other site 446469004217 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469004218 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469004219 DNA binding site [nucleotide binding] 446469004220 domain linker motif; other site 446469004221 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469004222 dimerization interface [polypeptide binding]; other site 446469004223 ligand binding site [chemical binding]; other site 446469004224 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 446469004225 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 446469004226 putative active site [active] 446469004227 putative catalytic site [active] 446469004228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469004229 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446469004230 Coenzyme A binding pocket [chemical binding]; other site 446469004231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469004232 DNA-binding site [nucleotide binding]; DNA binding site 446469004233 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446469004234 UTRA domain; Region: UTRA; pfam07702 446469004235 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 446469004236 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 446469004237 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 446469004238 Na binding site [ion binding]; other site 446469004239 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446469004240 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446469004241 substrate binding site [chemical binding]; other site 446469004242 ATP binding site [chemical binding]; other site 446469004243 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446469004244 anti sigma factor interaction site; other site 446469004245 regulatory phosphorylation site [posttranslational modification]; other site 446469004246 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469004247 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446469004248 nucleotide binding site [chemical binding]; other site 446469004249 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446469004250 active site 446469004251 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 446469004252 oligomerization interface [polypeptide binding]; other site 446469004253 active site 446469004254 metal binding site [ion binding]; metal-binding site 446469004255 NAD synthetase; Provisional; Region: PRK13981 446469004256 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 446469004257 multimer interface [polypeptide binding]; other site 446469004258 active site 446469004259 catalytic triad [active] 446469004260 protein interface 1 [polypeptide binding]; other site 446469004261 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 446469004262 homodimer interface [polypeptide binding]; other site 446469004263 NAD binding pocket [chemical binding]; other site 446469004264 ATP binding pocket [chemical binding]; other site 446469004265 Mg binding site [ion binding]; other site 446469004266 active-site loop [active] 446469004267 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 446469004268 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446469004269 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446469004270 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 446469004271 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446469004272 metal binding triad; other site 446469004273 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446469004274 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446469004275 metal binding triad; other site 446469004276 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446469004277 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 446469004278 Domain of unknown function DUF20; Region: UPF0118; pfam01594 446469004279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469004280 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 446469004281 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446469004282 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 446469004283 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 446469004284 NAD binding site [chemical binding]; other site 446469004285 catalytic Zn binding site [ion binding]; other site 446469004286 substrate binding site [chemical binding]; other site 446469004287 structural Zn binding site [ion binding]; other site 446469004288 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 446469004289 cyclase homology domain; Region: CHD; cd07302 446469004290 nucleotidyl binding site; other site 446469004291 metal binding site [ion binding]; metal-binding site 446469004292 dimer interface [polypeptide binding]; other site 446469004293 glutamine synthetase, type I; Region: GlnA; TIGR00653 446469004294 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446469004295 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446469004296 RDD family; Region: RDD; pfam06271 446469004297 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 446469004298 lipoyl synthase; Provisional; Region: PRK05481 446469004299 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446469004300 FeS/SAM binding site; other site 446469004301 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 446469004302 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469004303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469004304 putative Zn2+ binding site [ion binding]; other site 446469004305 putative DNA binding site [nucleotide binding]; other site 446469004306 MMPL family; Region: MMPL; pfam03176 446469004307 MMPL family; Region: MMPL; pfam03176 446469004308 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446469004309 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446469004310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469004311 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 446469004312 NAD(P) binding site [chemical binding]; other site 446469004313 active site 446469004314 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 446469004315 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446469004316 E3 interaction surface; other site 446469004317 lipoyl attachment site [posttranslational modification]; other site 446469004318 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446469004319 E3 interaction surface; other site 446469004320 lipoyl attachment site [posttranslational modification]; other site 446469004321 e3 binding domain; Region: E3_binding; pfam02817 446469004322 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446469004323 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 446469004324 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 446469004325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446469004326 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446469004327 hydroxypyruvate reductase; Region: PLN02306 446469004328 multifunctional aminopeptidase A; Provisional; Region: PRK00913 446469004329 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 446469004330 interface (dimer of trimers) [polypeptide binding]; other site 446469004331 Substrate-binding/catalytic site; other site 446469004332 Zn-binding sites [ion binding]; other site 446469004333 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 446469004334 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 446469004335 quinone interaction residues [chemical binding]; other site 446469004336 active site 446469004337 catalytic residues [active] 446469004338 FMN binding site [chemical binding]; other site 446469004339 substrate binding site [chemical binding]; other site 446469004340 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469004341 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469004342 active site 446469004343 catalytic tetrad [active] 446469004344 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 446469004345 hypothetical protein; Provisional; Region: PRK07907 446469004346 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 446469004347 active site 446469004348 metal binding site [ion binding]; metal-binding site 446469004349 dimer interface [polypeptide binding]; other site 446469004350 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446469004351 active site 446469004352 quinolinate synthetase; Provisional; Region: PRK09375 446469004353 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 446469004354 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 446469004355 CPxP motif; other site 446469004356 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 446469004357 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446469004358 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 446469004359 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 446469004360 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 446469004361 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 446469004362 D-pathway; other site 446469004363 Putative ubiquinol binding site [chemical binding]; other site 446469004364 Low-spin heme (heme b) binding site [chemical binding]; other site 446469004365 Putative water exit pathway; other site 446469004366 Binuclear center (heme o3/CuB) [ion binding]; other site 446469004367 K-pathway; other site 446469004368 Putative proton exit pathway; other site 446469004369 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 446469004370 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 446469004371 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 446469004372 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 446469004373 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 446469004374 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 446469004375 heme bH binding site [chemical binding]; other site 446469004376 intrachain domain interface; other site 446469004377 heme bL binding site [chemical binding]; other site 446469004378 interchain domain interface [polypeptide binding]; other site 446469004379 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 446469004380 Qo binding site; other site 446469004381 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 446469004382 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 446469004383 iron-sulfur cluster [ion binding]; other site 446469004384 [2Fe-2S] cluster binding site [ion binding]; other site 446469004385 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 446469004386 Cytochrome c; Region: Cytochrom_C; pfam00034 446469004387 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 446469004388 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 446469004389 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 446469004390 Subunit I/III interface [polypeptide binding]; other site 446469004391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 446469004392 active site 446469004393 phosphorylation site [posttranslational modification] 446469004394 intermolecular recognition site; other site 446469004395 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 446469004396 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446469004397 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446469004398 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446469004399 AsnC family; Region: AsnC_trans_reg; pfam01037 446469004400 hypothetical protein; Validated; Region: PRK07883 446469004401 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446469004402 active site 446469004403 catalytic site [active] 446469004404 substrate binding site [chemical binding]; other site 446469004405 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 446469004406 GIY-YIG motif/motif A; other site 446469004407 active site 446469004408 catalytic site [active] 446469004409 putative DNA binding site [nucleotide binding]; other site 446469004410 metal binding site [ion binding]; metal-binding site 446469004411 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446469004412 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 446469004413 acyl-activating enzyme (AAE) consensus motif; other site 446469004414 putative AMP binding site [chemical binding]; other site 446469004415 putative active site [active] 446469004416 putative CoA binding site [chemical binding]; other site 446469004417 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 446469004418 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446469004419 nucleotide binding site [chemical binding]; other site 446469004420 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446469004421 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446469004422 putative acyl-acceptor binding pocket; other site 446469004423 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 446469004424 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 446469004425 active site 446469004426 ADP/pyrophosphate binding site [chemical binding]; other site 446469004427 allosteric effector site; other site 446469004428 fructose-1,6-bisphosphate binding site; other site 446469004429 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 446469004430 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446469004431 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446469004432 active site 446469004433 ATP binding site [chemical binding]; other site 446469004434 substrate binding site [chemical binding]; other site 446469004435 activation loop (A-loop); other site 446469004436 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446469004437 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446469004438 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446469004439 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446469004440 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 446469004441 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 446469004442 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 446469004443 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 446469004444 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446469004445 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446469004446 catalytic residue [active] 446469004447 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446469004448 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446469004449 substrate binding pocket [chemical binding]; other site 446469004450 chain length determination region; other site 446469004451 substrate-Mg2+ binding site; other site 446469004452 catalytic residues [active] 446469004453 aspartate-rich region 1; other site 446469004454 active site lid residues [active] 446469004455 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 446469004456 aspartate-rich region 2; other site 446469004457 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 446469004458 Universal stress protein family; Region: Usp; pfam00582 446469004459 Ligand Binding Site [chemical binding]; other site 446469004460 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446469004461 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446469004462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469004463 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446469004464 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469004465 DNA binding residues [nucleotide binding] 446469004466 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 446469004467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469004468 ATP binding site [chemical binding]; other site 446469004469 Mg2+ binding site [ion binding]; other site 446469004470 G-X-G motif; other site 446469004471 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 446469004472 anchoring element; other site 446469004473 dimer interface [polypeptide binding]; other site 446469004474 ATP binding site [chemical binding]; other site 446469004475 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 446469004476 active site 446469004477 metal binding site [ion binding]; metal-binding site 446469004478 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446469004479 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446469004480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469004481 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446469004482 Coenzyme A binding pocket [chemical binding]; other site 446469004483 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 446469004484 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 446469004485 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446469004486 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446469004487 Walker A/P-loop; other site 446469004488 ATP binding site [chemical binding]; other site 446469004489 Q-loop/lid; other site 446469004490 ABC transporter signature motif; other site 446469004491 Walker B; other site 446469004492 D-loop; other site 446469004493 H-loop/switch region; other site 446469004494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469004495 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446469004496 Walker A/P-loop; other site 446469004497 ATP binding site [chemical binding]; other site 446469004498 Q-loop/lid; other site 446469004499 ABC transporter signature motif; other site 446469004500 Walker B; other site 446469004501 D-loop; other site 446469004502 H-loop/switch region; other site 446469004503 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 446469004504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469004505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469004506 Protein of unknown function (DUF418); Region: DUF418; cl12135 446469004507 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446469004508 Phosphotransferase enzyme family; Region: APH; pfam01636 446469004509 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446469004510 active site 446469004511 ATP binding site [chemical binding]; other site 446469004512 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 446469004513 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 446469004514 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 446469004515 substrate binding pocket [chemical binding]; other site 446469004516 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 446469004517 B12 binding site [chemical binding]; other site 446469004518 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 446469004519 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446469004520 extended (e) SDRs; Region: SDR_e; cd08946 446469004521 NAD(P) binding site [chemical binding]; other site 446469004522 active site 446469004523 substrate binding site [chemical binding]; other site 446469004524 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 446469004525 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 446469004526 CAP-like domain; other site 446469004527 active site 446469004528 primary dimer interface [polypeptide binding]; other site 446469004529 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446469004530 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446469004531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469004532 Coenzyme A binding pocket [chemical binding]; other site 446469004533 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 446469004534 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 446469004535 Uncharacterized conserved protein [Function unknown]; Region: COG3379 446469004536 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 446469004537 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 446469004538 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 446469004539 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446469004540 active site 446469004541 dimerization interface [polypeptide binding]; other site 446469004542 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 446469004543 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 446469004544 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446469004545 trimer interface [polypeptide binding]; other site 446469004546 active site 446469004547 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 446469004548 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 446469004549 ssDNA binding site; other site 446469004550 generic binding surface II; other site 446469004551 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 446469004552 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 446469004553 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446469004554 TrkA-N domain; Region: TrkA_N; pfam02254 446469004555 TrkA-C domain; Region: TrkA_C; pfam02080 446469004556 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446469004557 TrkA-N domain; Region: TrkA_N; pfam02254 446469004558 TrkA-C domain; Region: TrkA_C; pfam02080 446469004559 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 446469004560 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446469004561 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446469004562 active site 446469004563 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 446469004564 TRAM domain; Region: TRAM; pfam01938 446469004565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469004566 S-adenosylmethionine binding site [chemical binding]; other site 446469004567 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 446469004568 non-specific DNA binding site [nucleotide binding]; other site 446469004569 salt bridge; other site 446469004570 sequence-specific DNA binding site [nucleotide binding]; other site 446469004571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469004572 sequence-specific DNA binding site [nucleotide binding]; other site 446469004573 salt bridge; other site 446469004574 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 446469004575 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446469004576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469004577 motif II; other site 446469004578 aconitate hydratase; Validated; Region: PRK09277 446469004579 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446469004580 substrate binding site [chemical binding]; other site 446469004581 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446469004582 ligand binding site [chemical binding]; other site 446469004583 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 446469004584 substrate binding site [chemical binding]; other site 446469004585 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 446469004586 Phosphotransferase enzyme family; Region: APH; pfam01636 446469004587 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446469004588 active site 446469004589 substrate binding site [chemical binding]; other site 446469004590 ATP binding site [chemical binding]; other site 446469004591 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 446469004592 catalytic triad [active] 446469004593 Putative esterase; Region: Esterase; pfam00756 446469004594 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 446469004595 putative active site [active] 446469004596 putative CoA binding site [chemical binding]; other site 446469004597 nudix motif; other site 446469004598 metal binding site [ion binding]; metal-binding site 446469004599 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 446469004600 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 446469004601 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 446469004602 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 446469004603 active site 446469004604 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 446469004605 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 446469004606 TPP-binding site; other site 446469004607 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446469004608 PYR/PP interface [polypeptide binding]; other site 446469004609 dimer interface [polypeptide binding]; other site 446469004610 TPP binding site [chemical binding]; other site 446469004611 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446469004612 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 446469004613 Pyruvate formate lyase 1; Region: PFL1; cd01678 446469004614 coenzyme A binding site [chemical binding]; other site 446469004615 active site 446469004616 catalytic residues [active] 446469004617 glycine loop; other site 446469004618 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 446469004619 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446469004620 FeS/SAM binding site; other site 446469004621 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446469004622 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446469004623 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446469004624 substrate binding site [chemical binding]; other site 446469004625 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 446469004626 oxyanion hole (OAH) forming residues; other site 446469004627 trimer interface [polypeptide binding]; other site 446469004628 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446469004629 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446469004630 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446469004631 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446469004632 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 446469004633 dimer interface [polypeptide binding]; other site 446469004634 active site 446469004635 FemAB family; Region: FemAB; pfam02388 446469004636 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 446469004637 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 446469004638 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 446469004639 catalytic site [active] 446469004640 putative active site [active] 446469004641 putative substrate binding site [chemical binding]; other site 446469004642 HRDC domain; Region: HRDC; pfam00570 446469004643 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 446469004644 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446469004645 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 446469004646 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 446469004647 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446469004648 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 446469004649 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 446469004650 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 446469004651 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 446469004652 Leucine rich repeat; Region: LRR_8; pfam13855 446469004653 SdpI/YhfL protein family; Region: SdpI; pfam13630 446469004654 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 446469004655 putative active site [active] 446469004656 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446469004657 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469004658 Walker A/P-loop; other site 446469004659 ATP binding site [chemical binding]; other site 446469004660 Q-loop/lid; other site 446469004661 ABC transporter signature motif; other site 446469004662 Walker B; other site 446469004663 D-loop; other site 446469004664 H-loop/switch region; other site 446469004665 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469004666 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469004667 Walker A/P-loop; other site 446469004668 ATP binding site [chemical binding]; other site 446469004669 Q-loop/lid; other site 446469004670 ABC transporter signature motif; other site 446469004671 Walker B; other site 446469004672 D-loop; other site 446469004673 H-loop/switch region; other site 446469004674 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469004675 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446469004676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469004677 dimer interface [polypeptide binding]; other site 446469004678 conserved gate region; other site 446469004679 putative PBP binding loops; other site 446469004680 ABC-ATPase subunit interface; other site 446469004681 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 446469004682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469004683 dimer interface [polypeptide binding]; other site 446469004684 conserved gate region; other site 446469004685 putative PBP binding loops; other site 446469004686 ABC-ATPase subunit interface; other site 446469004687 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446469004688 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 446469004689 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 446469004690 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 446469004691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469004692 non-specific DNA binding site [nucleotide binding]; other site 446469004693 salt bridge; other site 446469004694 sequence-specific DNA binding site [nucleotide binding]; other site 446469004695 Cupin domain; Region: Cupin_2; pfam07883 446469004696 Domain of unknown function (DUF427); Region: DUF427; pfam04248 446469004697 RibD C-terminal domain; Region: RibD_C; cl17279 446469004698 Fe-S metabolism associated domain; Region: SufE; cl00951 446469004699 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 446469004700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446469004701 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 446469004702 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446469004703 catalytic Zn binding site [ion binding]; other site 446469004704 NAD(P) binding site [chemical binding]; other site 446469004705 structural Zn binding site [ion binding]; other site 446469004706 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 446469004707 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 446469004708 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 446469004709 catalytic site [active] 446469004710 active site 446469004711 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446469004712 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 446469004713 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 446469004714 active site 446469004715 catalytic site [active] 446469004716 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 446469004717 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 446469004718 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 446469004719 active site 446469004720 catalytic site [active] 446469004721 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 446469004722 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446469004723 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446469004724 metal binding site [ion binding]; metal-binding site 446469004725 active site 446469004726 I-site; other site 446469004727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469004728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469004729 dimer interface [polypeptide binding]; other site 446469004730 phosphorylation site [posttranslational modification] 446469004731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469004732 ATP binding site [chemical binding]; other site 446469004733 Mg2+ binding site [ion binding]; other site 446469004734 G-X-G motif; other site 446469004735 aminodeoxychorismate synthase; Provisional; Region: PRK07508 446469004736 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446469004737 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 446469004738 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 446469004739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469004740 catalytic residue [active] 446469004741 Copper resistance protein D; Region: CopD; pfam05425 446469004742 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 446469004743 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 446469004744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469004745 NAD(P) binding site [chemical binding]; other site 446469004746 active site 446469004747 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469004748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469004749 active site 446469004750 phosphorylation site [posttranslational modification] 446469004751 intermolecular recognition site; other site 446469004752 dimerization interface [polypeptide binding]; other site 446469004753 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469004754 DNA binding residues [nucleotide binding] 446469004755 dimerization interface [polypeptide binding]; other site 446469004756 Histidine kinase; Region: HisKA_3; pfam07730 446469004757 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446469004758 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 446469004759 FMN binding site [chemical binding]; other site 446469004760 dimer interface [polypeptide binding]; other site 446469004761 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446469004762 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 446469004763 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446469004764 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446469004765 Walker A/P-loop; other site 446469004766 ATP binding site [chemical binding]; other site 446469004767 Q-loop/lid; other site 446469004768 ABC transporter signature motif; other site 446469004769 Walker B; other site 446469004770 D-loop; other site 446469004771 H-loop/switch region; other site 446469004772 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446469004773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469004774 dimer interface [polypeptide binding]; other site 446469004775 conserved gate region; other site 446469004776 putative PBP binding loops; other site 446469004777 ABC-ATPase subunit interface; other site 446469004778 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 446469004779 NMT1/THI5 like; Region: NMT1; pfam09084 446469004780 allophanate hydrolase; Provisional; Region: PRK08186 446469004781 Amidase; Region: Amidase; cl11426 446469004782 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446469004783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469004784 DNA-binding site [nucleotide binding]; DNA binding site 446469004785 FCD domain; Region: FCD; pfam07729 446469004786 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446469004787 active site 446469004788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446469004789 Histidine kinase; Region: HisKA_3; pfam07730 446469004790 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469004791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469004792 active site 446469004793 phosphorylation site [posttranslational modification] 446469004794 intermolecular recognition site; other site 446469004795 dimerization interface [polypeptide binding]; other site 446469004796 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469004797 DNA binding residues [nucleotide binding] 446469004798 dimerization interface [polypeptide binding]; other site 446469004799 Predicted transcriptional regulators [Transcription]; Region: COG1510 446469004800 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446469004801 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446469004802 siderophore binding site; other site 446469004803 AAA domain; Region: AAA_22; pfam13401 446469004804 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469004805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469004806 DNA binding residues [nucleotide binding] 446469004807 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 446469004808 Catalytic site [active] 446469004809 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 446469004810 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469004811 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469004812 DNA binding residues [nucleotide binding] 446469004813 Anti-sigma-K factor rskA; Region: RskA; pfam10099 446469004814 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 446469004815 Fasciclin domain; Region: Fasciclin; pfam02469 446469004816 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 446469004817 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 446469004818 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 446469004819 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446469004820 catalytic residues [active] 446469004821 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 446469004822 GAF domain; Region: GAF; pfam01590 446469004823 oxidoreductase; Provisional; Region: PRK06128 446469004824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469004825 NAD(P) binding site [chemical binding]; other site 446469004826 active site 446469004827 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 446469004828 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446469004829 NAD binding site [chemical binding]; other site 446469004830 catalytic Zn binding site [ion binding]; other site 446469004831 structural Zn binding site [ion binding]; other site 446469004832 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446469004833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469004834 NAD(P) binding site [chemical binding]; other site 446469004835 active site 446469004836 intracellular protease, PfpI family; Region: PfpI; TIGR01382 446469004837 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 446469004838 proposed catalytic triad [active] 446469004839 conserved cys residue [active] 446469004840 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 446469004841 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446469004842 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 446469004843 putative NAD(P) binding site [chemical binding]; other site 446469004844 putative active site [active] 446469004845 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 446469004846 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 446469004847 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 446469004848 Isochorismatase family; Region: Isochorismatase; pfam00857 446469004849 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 446469004850 catalytic triad [active] 446469004851 conserved cis-peptide bond; other site 446469004852 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 446469004853 Amidase; Region: Amidase; cl11426 446469004854 indole-3-acetamide amidohydrolase; Region: PLN02722 446469004855 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446469004856 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446469004857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469004858 non-specific DNA binding site [nucleotide binding]; other site 446469004859 salt bridge; other site 446469004860 sequence-specific DNA binding site [nucleotide binding]; other site 446469004861 Cupin domain; Region: Cupin_2; cl17218 446469004862 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446469004863 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 446469004864 active site 446469004865 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446469004866 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446469004867 Walker A/P-loop; other site 446469004868 ATP binding site [chemical binding]; other site 446469004869 Q-loop/lid; other site 446469004870 ABC transporter signature motif; other site 446469004871 Walker B; other site 446469004872 D-loop; other site 446469004873 H-loop/switch region; other site 446469004874 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446469004875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469004876 dimer interface [polypeptide binding]; other site 446469004877 conserved gate region; other site 446469004878 putative PBP binding loops; other site 446469004879 ABC-ATPase subunit interface; other site 446469004880 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446469004881 FAD binding domain; Region: FAD_binding_4; pfam01565 446469004882 Creatinine amidohydrolase; Region: Creatininase; pfam02633 446469004883 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 446469004884 Cupin domain; Region: Cupin_2; pfam07883 446469004885 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 446469004886 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446469004887 Amidohydrolase; Region: Amidohydro_4; pfam13147 446469004888 active site 446469004889 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446469004890 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 446469004891 dimer interface [polypeptide binding]; other site 446469004892 ligand binding site [chemical binding]; other site 446469004893 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446469004894 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 446469004895 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 446469004896 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 446469004897 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 446469004898 active site 446469004899 dimer interface [polypeptide binding]; other site 446469004900 motif 1; other site 446469004901 motif 2; other site 446469004902 motif 3; other site 446469004903 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 446469004904 anticodon binding site; other site 446469004905 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 446469004906 nucleotide binding site/active site [active] 446469004907 HIT family signature motif; other site 446469004908 catalytic residue [active] 446469004909 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 446469004910 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 446469004911 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 446469004912 putative acyl-acceptor binding pocket; other site 446469004913 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446469004914 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446469004915 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446469004916 nudix motif; other site 446469004917 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 446469004918 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446469004919 ATP binding site [chemical binding]; other site 446469004920 putative Mg++ binding site [ion binding]; other site 446469004921 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469004922 nucleotide binding region [chemical binding]; other site 446469004923 ATP-binding site [chemical binding]; other site 446469004924 hypothetical protein; Validated; Region: PRK00110 446469004925 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 446469004926 active site 446469004927 putative DNA-binding cleft [nucleotide binding]; other site 446469004928 dimer interface [polypeptide binding]; other site 446469004929 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 446469004930 RuvA N terminal domain; Region: RuvA_N; pfam01330 446469004931 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 446469004932 DNA binding site [nucleotide binding] 446469004933 metal binding site [ion binding]; metal-binding site 446469004934 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 446469004935 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 446469004936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469004937 Walker A motif; other site 446469004938 ATP binding site [chemical binding]; other site 446469004939 Walker B motif; other site 446469004940 arginine finger; other site 446469004941 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 446469004942 Preprotein translocase subunit; Region: YajC; pfam02699 446469004943 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 446469004944 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 446469004945 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 446469004946 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 446469004947 Protein export membrane protein; Region: SecD_SecF; pfam02355 446469004948 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446469004949 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 446469004950 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446469004951 Zn2+ binding site [ion binding]; other site 446469004952 Mg2+ binding site [ion binding]; other site 446469004953 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446469004954 synthetase active site [active] 446469004955 NTP binding site [chemical binding]; other site 446469004956 metal binding site [ion binding]; metal-binding site 446469004957 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 446469004958 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 446469004959 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446469004960 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446469004961 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 446469004962 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 446469004963 dimer interface [polypeptide binding]; other site 446469004964 motif 1; other site 446469004965 active site 446469004966 motif 2; other site 446469004967 motif 3; other site 446469004968 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 446469004969 anticodon binding site; other site 446469004970 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 446469004971 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 446469004972 dimer interface [polypeptide binding]; other site 446469004973 anticodon binding site; other site 446469004974 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 446469004975 homodimer interface [polypeptide binding]; other site 446469004976 motif 1; other site 446469004977 active site 446469004978 motif 2; other site 446469004979 GAD domain; Region: GAD; pfam02938 446469004980 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446469004981 active site 446469004982 motif 3; other site 446469004983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446469004984 MMPL family; Region: MMPL; pfam03176 446469004985 MMPL family; Region: MMPL; pfam03176 446469004986 recombination factor protein RarA; Reviewed; Region: PRK13342 446469004987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469004988 Walker A motif; other site 446469004989 ATP binding site [chemical binding]; other site 446469004990 Walker B motif; other site 446469004991 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 446469004992 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 446469004993 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 446469004994 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446469004995 RNA binding surface [nucleotide binding]; other site 446469004996 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 446469004997 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 446469004998 motif 1; other site 446469004999 active site 446469005000 motif 2; other site 446469005001 motif 3; other site 446469005002 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 446469005003 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 446469005004 YceG-like family; Region: YceG; pfam02618 446469005005 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 446469005006 dimerization interface [polypeptide binding]; other site 446469005007 YceG-like family; Region: YceG; pfam02618 446469005008 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 446469005009 dimerization interface [polypeptide binding]; other site 446469005010 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 446469005011 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 446469005012 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 446469005013 NAD(P) binding site [chemical binding]; other site 446469005014 shikimate binding site; other site 446469005015 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 446469005016 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 446469005017 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 446469005018 Walker A motif; other site 446469005019 ATP binding site [chemical binding]; other site 446469005020 Walker B motif; other site 446469005021 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 446469005022 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 446469005023 Walker A motif; other site 446469005024 ATP binding site [chemical binding]; other site 446469005025 Walker B motif; other site 446469005026 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 446469005027 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 446469005028 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 446469005029 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 446469005030 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 446469005031 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 446469005032 Competence protein A; Region: Competence_A; pfam11104 446469005033 Cell division protein FtsA; Region: FtsA; cl17206 446469005034 Cell division protein FtsA; Region: FtsA; pfam14450 446469005035 Pilus assembly protein, PilO; Region: PilO; cl01234 446469005036 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 446469005037 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 446469005038 Tetramer interface [polypeptide binding]; other site 446469005039 active site 446469005040 FMN-binding site [chemical binding]; other site 446469005041 shikimate kinase; Reviewed; Region: aroK; PRK00131 446469005042 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 446469005043 ADP binding site [chemical binding]; other site 446469005044 magnesium binding site [ion binding]; other site 446469005045 putative shikimate binding site; other site 446469005046 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 446469005047 active site 446469005048 dimer interface [polypeptide binding]; other site 446469005049 metal binding site [ion binding]; metal-binding site 446469005050 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 446469005051 Dehydroquinase class II; Region: DHquinase_II; pfam01220 446469005052 active site 446469005053 trimer interface [polypeptide binding]; other site 446469005054 dimer interface [polypeptide binding]; other site 446469005055 elongation factor P; Validated; Region: PRK00529 446469005056 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 446469005057 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 446469005058 RNA binding site [nucleotide binding]; other site 446469005059 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 446469005060 RNA binding site [nucleotide binding]; other site 446469005061 transcription antitermination factor NusB; Region: nusB; TIGR01951 446469005062 putative RNA binding site [nucleotide binding]; other site 446469005063 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 446469005064 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 446469005065 acyl-activating enzyme (AAE) consensus motif; other site 446469005066 putative AMP binding site [chemical binding]; other site 446469005067 putative active site [active] 446469005068 putative CoA binding site [chemical binding]; other site 446469005069 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446469005070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469005071 putative substrate translocation pore; other site 446469005072 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 446469005073 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 446469005074 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 446469005075 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446469005076 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 446469005077 dihydroorotase; Validated; Region: pyrC; PRK09357 446469005078 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446469005079 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 446469005080 active site 446469005081 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 446469005082 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 446469005083 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 446469005084 catalytic site [active] 446469005085 subunit interface [polypeptide binding]; other site 446469005086 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 446469005087 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446469005088 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446469005089 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 446469005090 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446469005091 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446469005092 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 446469005093 IMP binding site; other site 446469005094 dimer interface [polypeptide binding]; other site 446469005095 interdomain contacts; other site 446469005096 partial ornithine binding site; other site 446469005097 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 446469005098 active site 446469005099 dimer interface [polypeptide binding]; other site 446469005100 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 446469005101 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 446469005102 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 446469005103 catalytic site [active] 446469005104 G-X2-G-X-G-K; other site 446469005105 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 446469005106 Flavoprotein; Region: Flavoprotein; pfam02441 446469005107 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 446469005108 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 446469005109 S-adenosylmethionine synthetase; Validated; Region: PRK05250 446469005110 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 446469005111 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 446469005112 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 446469005113 primosome assembly protein PriA; Provisional; Region: PRK14873 446469005114 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 446469005115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469005116 motif II; other site 446469005117 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 446469005118 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 446469005119 putative active site [active] 446469005120 substrate binding site [chemical binding]; other site 446469005121 putative cosubstrate binding site; other site 446469005122 catalytic site [active] 446469005123 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 446469005124 substrate binding site [chemical binding]; other site 446469005125 16S rRNA methyltransferase B; Provisional; Region: PRK14902 446469005126 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 446469005127 putative RNA binding site [nucleotide binding]; other site 446469005128 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 446469005129 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 446469005130 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 446469005131 substrate binding site [chemical binding]; other site 446469005132 hexamer interface [polypeptide binding]; other site 446469005133 metal binding site [ion binding]; metal-binding site 446469005134 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446469005135 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446469005136 Coenzyme A binding pocket [chemical binding]; other site 446469005137 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 446469005138 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 446469005139 catalytic motif [active] 446469005140 Zn binding site [ion binding]; other site 446469005141 RibD C-terminal domain; Region: RibD_C; cl17279 446469005142 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 446469005143 Lumazine binding domain; Region: Lum_binding; pfam00677 446469005144 Lumazine binding domain; Region: Lum_binding; pfam00677 446469005145 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 446469005146 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 446469005147 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 446469005148 dimerization interface [polypeptide binding]; other site 446469005149 active site 446469005150 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 446469005151 homopentamer interface [polypeptide binding]; other site 446469005152 active site 446469005153 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 446469005154 homodimer interface [polypeptide binding]; other site 446469005155 putative metal binding site [ion binding]; other site 446469005156 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 446469005157 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 446469005158 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 446469005159 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446469005160 helicase 45; Provisional; Region: PTZ00424 446469005161 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446469005162 ATP binding site [chemical binding]; other site 446469005163 Mg++ binding site [ion binding]; other site 446469005164 motif III; other site 446469005165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469005166 nucleotide binding region [chemical binding]; other site 446469005167 ATP-binding site [chemical binding]; other site 446469005168 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 446469005169 putative RNA binding site [nucleotide binding]; other site 446469005170 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 446469005171 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 446469005172 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 446469005173 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 446469005174 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446469005175 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446469005176 phosphopeptide binding site; other site 446469005177 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446469005178 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446469005179 DNA binding residues [nucleotide binding] 446469005180 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446469005181 DNA binding residues [nucleotide binding] 446469005182 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446469005183 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 446469005184 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446469005185 P-loop; other site 446469005186 Magnesium ion binding site [ion binding]; other site 446469005187 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446469005188 Magnesium ion binding site [ion binding]; other site 446469005189 pyruvate carboxylase; Reviewed; Region: PRK12999 446469005190 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446469005191 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446469005192 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 446469005193 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 446469005194 active site 446469005195 catalytic residues [active] 446469005196 metal binding site [ion binding]; metal-binding site 446469005197 homodimer binding site [polypeptide binding]; other site 446469005198 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446469005199 carboxyltransferase (CT) interaction site; other site 446469005200 biotinylation site [posttranslational modification]; other site 446469005201 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 446469005202 putative hydrophobic ligand binding site [chemical binding]; other site 446469005203 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 446469005204 PLD-like domain; Region: PLDc_2; pfam13091 446469005205 putative active site [active] 446469005206 catalytic site [active] 446469005207 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 446469005208 PLD-like domain; Region: PLDc_2; pfam13091 446469005209 putative active site [active] 446469005210 catalytic site [active] 446469005211 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446469005212 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 446469005213 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446469005214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469005215 non-specific DNA binding site [nucleotide binding]; other site 446469005216 salt bridge; other site 446469005217 sequence-specific DNA binding site [nucleotide binding]; other site 446469005218 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 446469005219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469005220 Walker A/P-loop; other site 446469005221 ATP binding site [chemical binding]; other site 446469005222 Q-loop/lid; other site 446469005223 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446469005224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469005225 Walker A/P-loop; other site 446469005226 ATP binding site [chemical binding]; other site 446469005227 Q-loop/lid; other site 446469005228 ABC transporter signature motif; other site 446469005229 Walker B; other site 446469005230 D-loop; other site 446469005231 H-loop/switch region; other site 446469005232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 446469005233 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446469005234 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 446469005235 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 446469005236 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469005237 dimerization interface [polypeptide binding]; other site 446469005238 putative DNA binding site [nucleotide binding]; other site 446469005239 putative Zn2+ binding site [ion binding]; other site 446469005240 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 446469005241 Yqey-like protein; Region: YqeY; pfam09424 446469005242 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446469005243 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 446469005244 Ligand binding site; other site 446469005245 Putative Catalytic site; other site 446469005246 DXD motif; other site 446469005247 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 446469005248 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 446469005249 putative active site [active] 446469005250 catalytic triad [active] 446469005251 putative dimer interface [polypeptide binding]; other site 446469005252 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 446469005253 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446469005254 active site 446469005255 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446469005256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469005257 ATP binding site [chemical binding]; other site 446469005258 putative Mg++ binding site [ion binding]; other site 446469005259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469005260 nucleotide binding region [chemical binding]; other site 446469005261 ATP-binding site [chemical binding]; other site 446469005262 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 446469005263 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 446469005264 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 446469005265 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 446469005266 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 446469005267 Predicted transcriptional regulator [Transcription]; Region: COG2378 446469005268 WYL domain; Region: WYL; pfam13280 446469005269 Predicted transcriptional regulator [Transcription]; Region: COG2378 446469005270 WYL domain; Region: WYL; pfam13280 446469005271 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 446469005272 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 446469005273 MoxR-like ATPases [General function prediction only]; Region: COG0714 446469005274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446469005275 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446469005276 Protein of unknown function DUF58; Region: DUF58; pfam01882 446469005277 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 446469005278 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 446469005279 dimerization interface [polypeptide binding]; other site 446469005280 DPS ferroxidase diiron center [ion binding]; other site 446469005281 ion pore; other site 446469005282 Uncharacterized conserved protein [Function unknown]; Region: COG1739 446469005283 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 446469005284 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446469005285 catalytic residues [active] 446469005286 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 446469005287 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 446469005288 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446469005289 MarR family; Region: MarR_2; cl17246 446469005290 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469005291 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 446469005292 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446469005293 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446469005294 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 446469005295 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446469005296 catalytic residue [active] 446469005297 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446469005298 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469005299 Walker A/P-loop; other site 446469005300 ATP binding site [chemical binding]; other site 446469005301 Q-loop/lid; other site 446469005302 ABC transporter signature motif; other site 446469005303 Walker B; other site 446469005304 D-loop; other site 446469005305 H-loop/switch region; other site 446469005306 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469005307 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446469005308 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469005309 Walker A/P-loop; other site 446469005310 ATP binding site [chemical binding]; other site 446469005311 Q-loop/lid; other site 446469005312 ABC transporter signature motif; other site 446469005313 Walker B; other site 446469005314 D-loop; other site 446469005315 H-loop/switch region; other site 446469005316 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469005317 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446469005318 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446469005319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469005320 dimer interface [polypeptide binding]; other site 446469005321 conserved gate region; other site 446469005322 putative PBP binding loops; other site 446469005323 ABC-ATPase subunit interface; other site 446469005324 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446469005325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469005326 dimer interface [polypeptide binding]; other site 446469005327 conserved gate region; other site 446469005328 putative PBP binding loops; other site 446469005329 ABC-ATPase subunit interface; other site 446469005330 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446469005331 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446469005332 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446469005333 active site 446469005334 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 446469005335 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469005336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469005337 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446469005338 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 446469005339 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 446469005340 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446469005341 tetramer interface [polypeptide binding]; other site 446469005342 TPP-binding site [chemical binding]; other site 446469005343 heterodimer interface [polypeptide binding]; other site 446469005344 phosphorylation loop region [posttranslational modification] 446469005345 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446469005346 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446469005347 alpha subunit interface [polypeptide binding]; other site 446469005348 TPP binding site [chemical binding]; other site 446469005349 heterodimer interface [polypeptide binding]; other site 446469005350 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446469005351 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 446469005352 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446469005353 E3 interaction surface; other site 446469005354 lipoyl attachment site [posttranslational modification]; other site 446469005355 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446469005356 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446469005357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469005358 dimer interface [polypeptide binding]; other site 446469005359 putative PBP binding loops; other site 446469005360 ABC-ATPase subunit interface; other site 446469005361 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469005362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469005363 dimer interface [polypeptide binding]; other site 446469005364 conserved gate region; other site 446469005365 putative PBP binding loops; other site 446469005366 ABC-ATPase subunit interface; other site 446469005367 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469005368 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446469005369 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 446469005370 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446469005371 active site 446469005372 catalytic site [active] 446469005373 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 446469005374 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 446469005375 malonyl-CoA binding site [chemical binding]; other site 446469005376 dimer interface [polypeptide binding]; other site 446469005377 active site 446469005378 product binding site; other site 446469005379 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 446469005380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469005381 S-adenosylmethionine binding site [chemical binding]; other site 446469005382 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446469005383 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446469005384 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446469005385 active site 446469005386 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446469005387 BCCT family transporter; Region: BCCT; pfam02028 446469005388 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 446469005389 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 446469005390 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 446469005391 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469005392 ATP binding site [chemical binding]; other site 446469005393 putative Mg++ binding site [ion binding]; other site 446469005394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469005395 nucleotide binding region [chemical binding]; other site 446469005396 ATP-binding site [chemical binding]; other site 446469005397 Helicase associated domain (HA2); Region: HA2; cl04503 446469005398 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 446469005399 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 446469005400 dimer interface [polypeptide binding]; other site 446469005401 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446469005402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469005403 Walker A/P-loop; other site 446469005404 ATP binding site [chemical binding]; other site 446469005405 Q-loop/lid; other site 446469005406 ABC transporter signature motif; other site 446469005407 Walker B; other site 446469005408 D-loop; other site 446469005409 H-loop/switch region; other site 446469005410 ABC transporter; Region: ABC_tran_2; pfam12848 446469005411 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469005412 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 446469005413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469005414 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446469005415 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446469005416 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 446469005417 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 446469005418 DXD motif; other site 446469005419 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 446469005420 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 446469005421 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 446469005422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446469005423 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446469005424 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446469005425 siderophore binding site; other site 446469005426 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446469005427 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469005428 ABC-ATPase subunit interface; other site 446469005429 dimer interface [polypeptide binding]; other site 446469005430 putative PBP binding regions; other site 446469005431 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469005432 ABC-ATPase subunit interface; other site 446469005433 dimer interface [polypeptide binding]; other site 446469005434 putative PBP binding regions; other site 446469005435 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446469005436 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446469005437 Walker A/P-loop; other site 446469005438 ATP binding site [chemical binding]; other site 446469005439 Q-loop/lid; other site 446469005440 ABC transporter signature motif; other site 446469005441 Walker B; other site 446469005442 D-loop; other site 446469005443 H-loop/switch region; other site 446469005444 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 446469005445 putative hydrophobic ligand binding site [chemical binding]; other site 446469005446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469005447 dimerization interface [polypeptide binding]; other site 446469005448 putative DNA binding site [nucleotide binding]; other site 446469005449 putative Zn2+ binding site [ion binding]; other site 446469005450 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446469005451 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446469005452 active site 446469005453 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 446469005454 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446469005455 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446469005456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469005457 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446469005458 Walker A/P-loop; other site 446469005459 ATP binding site [chemical binding]; other site 446469005460 Q-loop/lid; other site 446469005461 ABC transporter signature motif; other site 446469005462 Walker B; other site 446469005463 D-loop; other site 446469005464 H-loop/switch region; other site 446469005465 MbtH-like protein; Region: MbtH; pfam03621 446469005466 Condensation domain; Region: Condensation; pfam00668 446469005467 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446469005468 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446469005469 acyl-activating enzyme (AAE) consensus motif; other site 446469005470 AMP binding site [chemical binding]; other site 446469005471 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446469005472 Condensation domain; Region: Condensation; pfam00668 446469005473 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446469005474 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446469005475 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446469005476 acyl-activating enzyme (AAE) consensus motif; other site 446469005477 AMP binding site [chemical binding]; other site 446469005478 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446469005479 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 446469005480 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446469005481 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446469005482 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446469005483 acyl-activating enzyme (AAE) consensus motif; other site 446469005484 AMP binding site [chemical binding]; other site 446469005485 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446469005486 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 446469005487 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 446469005488 RNAase interaction site [polypeptide binding]; other site 446469005489 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446469005490 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446469005491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469005492 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446469005493 NAD(P) binding site [chemical binding]; other site 446469005494 active site 446469005495 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446469005496 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 446469005497 putative NAD(P) binding site [chemical binding]; other site 446469005498 putative substrate binding site [chemical binding]; other site 446469005499 catalytic Zn binding site [ion binding]; other site 446469005500 structural Zn binding site [ion binding]; other site 446469005501 dimer interface [polypeptide binding]; other site 446469005502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469005503 salt bridge; other site 446469005504 non-specific DNA binding site [nucleotide binding]; other site 446469005505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446469005506 sequence-specific DNA binding site [nucleotide binding]; other site 446469005507 Predicted integral membrane protein [Function unknown]; Region: COG5637 446469005508 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446469005509 CoA binding domain; Region: CoA_binding_2; pfam13380 446469005510 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 446469005511 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446469005512 homodimer interface [polypeptide binding]; other site 446469005513 substrate-cofactor binding pocket; other site 446469005514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469005515 catalytic residue [active] 446469005516 acetyl-CoA synthetase; Provisional; Region: PRK00174 446469005517 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446469005518 acyl-activating enzyme (AAE) consensus motif; other site 446469005519 AMP binding site [chemical binding]; other site 446469005520 active site 446469005521 CoA binding site [chemical binding]; other site 446469005522 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446469005523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469005524 dimer interface [polypeptide binding]; other site 446469005525 conserved gate region; other site 446469005526 putative PBP binding loops; other site 446469005527 ABC-ATPase subunit interface; other site 446469005528 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 446469005529 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446469005530 substrate binding pocket [chemical binding]; other site 446469005531 membrane-bound complex binding site; other site 446469005532 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446469005533 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446469005534 Walker A/P-loop; other site 446469005535 ATP binding site [chemical binding]; other site 446469005536 Q-loop/lid; other site 446469005537 ABC transporter signature motif; other site 446469005538 Walker B; other site 446469005539 D-loop; other site 446469005540 H-loop/switch region; other site 446469005541 WHG domain; Region: WHG; pfam13305 446469005542 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 446469005543 active site 446469005544 catalytic triad [active] 446469005545 oxyanion hole [active] 446469005546 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446469005547 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446469005548 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446469005549 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446469005550 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 446469005551 dinuclear metal binding motif [ion binding]; other site 446469005552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469005553 fatty acyl-CoA reductase; Region: PLN02996 446469005554 NAD(P) binding site [chemical binding]; other site 446469005555 active site 446469005556 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 446469005557 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446469005558 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446469005559 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 446469005560 classical (c) SDRs; Region: SDR_c; cd05233 446469005561 NAD(P) binding site [chemical binding]; other site 446469005562 active site 446469005563 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446469005564 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446469005565 putative acyl-acceptor binding pocket; other site 446469005566 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446469005567 FAD binding domain; Region: FAD_binding_4; pfam01565 446469005568 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446469005569 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446469005570 intersubunit interface [polypeptide binding]; other site 446469005571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446469005572 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446469005573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446469005574 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 446469005575 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 446469005576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469005577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469005578 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446469005579 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446469005580 putative acyl-acceptor binding pocket; other site 446469005581 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 446469005582 phosphatidate cytidylyltransferase; Region: PLN02953 446469005583 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 446469005584 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 446469005585 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 446469005586 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 446469005587 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446469005588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469005589 ABC transporter signature motif; other site 446469005590 Walker B; other site 446469005591 D-loop; other site 446469005592 H-loop/switch region; other site 446469005593 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 446469005594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469005595 salt bridge; other site 446469005596 non-specific DNA binding site [nucleotide binding]; other site 446469005597 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446469005598 sequence-specific DNA binding site [nucleotide binding]; other site 446469005599 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446469005600 classical (c) SDRs; Region: SDR_c; cd05233 446469005601 NAD(P) binding site [chemical binding]; other site 446469005602 active site 446469005603 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 446469005604 TIGR02569 family protein; Region: TIGR02569_actnb 446469005605 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 446469005606 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 446469005607 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 446469005608 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446469005609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469005610 S-adenosylmethionine binding site [chemical binding]; other site 446469005611 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446469005612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446469005613 short chain dehydrogenase; Provisional; Region: PRK06197 446469005614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469005615 NAD(P) binding site [chemical binding]; other site 446469005616 active site 446469005617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469005618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469005619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469005620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469005621 active site 446469005622 phosphorylation site [posttranslational modification] 446469005623 intermolecular recognition site; other site 446469005624 dimerization interface [polypeptide binding]; other site 446469005625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469005626 DNA binding residues [nucleotide binding] 446469005627 dimerization interface [polypeptide binding]; other site 446469005628 Histidine kinase; Region: HisKA_3; pfam07730 446469005629 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446469005630 ATP binding site [chemical binding]; other site 446469005631 Mg2+ binding site [ion binding]; other site 446469005632 G-X-G motif; other site 446469005633 MMPL family; Region: MMPL; pfam03176 446469005634 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446469005635 Protein export membrane protein; Region: SecD_SecF; cl14618 446469005636 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446469005637 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469005638 ATP binding site [chemical binding]; other site 446469005639 putative Mg++ binding site [ion binding]; other site 446469005640 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469005641 nucleotide binding region [chemical binding]; other site 446469005642 ATP-binding site [chemical binding]; other site 446469005643 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 446469005644 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 446469005645 active site 446469005646 substrate binding site; other site 446469005647 GTP-binding protein Der; Reviewed; Region: PRK03003 446469005648 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 446469005649 G1 box; other site 446469005650 GTP/Mg2+ binding site [chemical binding]; other site 446469005651 Switch I region; other site 446469005652 G2 box; other site 446469005653 Switch II region; other site 446469005654 G3 box; other site 446469005655 G4 box; other site 446469005656 G5 box; other site 446469005657 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 446469005658 G1 box; other site 446469005659 GTP/Mg2+ binding site [chemical binding]; other site 446469005660 Switch I region; other site 446469005661 G2 box; other site 446469005662 G3 box; other site 446469005663 Switch II region; other site 446469005664 G4 box; other site 446469005665 G5 box; other site 446469005666 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 446469005667 putative active site [active] 446469005668 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446469005669 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446469005670 putative acyl-acceptor binding pocket; other site 446469005671 cytidylate kinase; Provisional; Region: cmk; PRK00023 446469005672 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 446469005673 CMP-binding site; other site 446469005674 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 446469005675 homotrimer interaction site [polypeptide binding]; other site 446469005676 active site 446469005677 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 446469005678 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446469005679 RNA binding surface [nucleotide binding]; other site 446469005680 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 446469005681 active site 446469005682 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 446469005683 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 446469005684 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446469005685 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446469005686 P-loop; other site 446469005687 Magnesium ion binding site [ion binding]; other site 446469005688 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446469005689 Magnesium ion binding site [ion binding]; other site 446469005690 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 446469005691 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446469005692 active site 446469005693 DNA binding site [nucleotide binding] 446469005694 Int/Topo IB signature motif; other site 446469005695 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 446469005696 UbiA prenyltransferase family; Region: UbiA; pfam01040 446469005697 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 446469005698 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 446469005699 TPP-binding site [chemical binding]; other site 446469005700 dimer interface [polypeptide binding]; other site 446469005701 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446469005702 PYR/PP interface [polypeptide binding]; other site 446469005703 dimer interface [polypeptide binding]; other site 446469005704 TPP binding site [chemical binding]; other site 446469005705 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446469005706 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 446469005707 putative active site [active] 446469005708 transaldolase; Provisional; Region: PRK03903 446469005709 catalytic residue [active] 446469005710 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 446469005711 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 446469005712 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 446469005713 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 446469005714 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 446469005715 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 446469005716 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 446469005717 putative active site [active] 446469005718 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 446469005719 Preprotein translocase SecG subunit; Region: SecG; pfam03840 446469005720 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 446469005721 triosephosphate isomerase; Provisional; Region: PRK14565 446469005722 substrate binding site [chemical binding]; other site 446469005723 dimer interface [polypeptide binding]; other site 446469005724 catalytic triad [active] 446469005725 Phosphoglycerate kinase; Region: PGK; pfam00162 446469005726 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 446469005727 substrate binding site [chemical binding]; other site 446469005728 hinge regions; other site 446469005729 ADP binding site [chemical binding]; other site 446469005730 catalytic site [active] 446469005731 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 446469005732 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 446469005733 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 446469005734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 446469005735 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 446469005736 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 446469005737 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 446469005738 putative substrate binding pocket [chemical binding]; other site 446469005739 dimer interface [polypeptide binding]; other site 446469005740 phosphate binding site [ion binding]; other site 446469005741 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 446469005742 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 446469005743 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 446469005744 GIY-YIG motif/motif A; other site 446469005745 active site 446469005746 catalytic site [active] 446469005747 putative DNA binding site [nucleotide binding]; other site 446469005748 metal binding site [ion binding]; metal-binding site 446469005749 UvrB/uvrC motif; Region: UVR; pfam02151 446469005750 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 446469005751 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 446469005752 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446469005753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446469005754 active site 446469005755 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446469005756 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446469005757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469005758 S-adenosylmethionine binding site [chemical binding]; other site 446469005759 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 446469005760 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446469005761 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446469005762 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 446469005763 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446469005764 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 446469005765 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 446469005766 YCII-related domain; Region: YCII; cl00999 446469005767 excinuclease ABC subunit B; Provisional; Region: PRK05298 446469005768 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469005769 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469005770 nucleotide binding region [chemical binding]; other site 446469005771 ATP-binding site [chemical binding]; other site 446469005772 Ultra-violet resistance protein B; Region: UvrB; pfam12344 446469005773 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 446469005774 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 446469005775 CoA-binding site [chemical binding]; other site 446469005776 ATP-binding [chemical binding]; other site 446469005777 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446469005778 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469005779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469005780 Walker A/P-loop; other site 446469005781 ATP binding site [chemical binding]; other site 446469005782 Q-loop/lid; other site 446469005783 ABC transporter signature motif; other site 446469005784 Walker B; other site 446469005785 D-loop; other site 446469005786 H-loop/switch region; other site 446469005787 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 446469005788 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 446469005789 RNA binding site [nucleotide binding]; other site 446469005790 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 446469005791 RNA binding site [nucleotide binding]; other site 446469005792 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446469005793 RNA binding site [nucleotide binding]; other site 446469005794 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 446469005795 RNA binding site [nucleotide binding]; other site 446469005796 6-phosphofructokinase; Provisional; Region: PRK03202 446469005797 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 446469005798 active site 446469005799 ADP/pyrophosphate binding site [chemical binding]; other site 446469005800 dimerization interface [polypeptide binding]; other site 446469005801 allosteric effector site; other site 446469005802 fructose-1,6-bisphosphate binding site; other site 446469005803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469005804 S-adenosylmethionine binding site [chemical binding]; other site 446469005805 DNA polymerase I; Provisional; Region: PRK05755 446469005806 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 446469005807 active site 446469005808 metal binding site 1 [ion binding]; metal-binding site 446469005809 putative 5' ssDNA interaction site; other site 446469005810 metal binding site 3; metal-binding site 446469005811 metal binding site 2 [ion binding]; metal-binding site 446469005812 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 446469005813 putative DNA binding site [nucleotide binding]; other site 446469005814 putative metal binding site [ion binding]; other site 446469005815 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 446469005816 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 446469005817 active site 446469005818 DNA binding site [nucleotide binding] 446469005819 catalytic site [active] 446469005820 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446469005821 CoenzymeA binding site [chemical binding]; other site 446469005822 subunit interaction site [polypeptide binding]; other site 446469005823 PHB binding site; other site 446469005824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469005825 Coenzyme A binding pocket [chemical binding]; other site 446469005826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469005827 Response regulator receiver domain; Region: Response_reg; pfam00072 446469005828 active site 446469005829 phosphorylation site [posttranslational modification] 446469005830 intermolecular recognition site; other site 446469005831 dimerization interface [polypeptide binding]; other site 446469005832 ANTAR domain; Region: ANTAR; pfam03861 446469005833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469005834 salt bridge; other site 446469005835 non-specific DNA binding site [nucleotide binding]; other site 446469005836 sequence-specific DNA binding site [nucleotide binding]; other site 446469005837 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446469005838 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446469005839 putative NAD(P) binding site [chemical binding]; other site 446469005840 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 446469005841 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446469005842 catalytic Zn binding site [ion binding]; other site 446469005843 NAD(P) binding site [chemical binding]; other site 446469005844 structural Zn binding site [ion binding]; other site 446469005845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469005846 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446469005847 salt bridge; other site 446469005848 non-specific DNA binding site [nucleotide binding]; other site 446469005849 sequence-specific DNA binding site [nucleotide binding]; other site 446469005850 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446469005851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469005852 putative substrate translocation pore; other site 446469005853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469005854 NAD(P) binding site [chemical binding]; other site 446469005855 active site 446469005856 Uncharacterized conserved protein [Function unknown]; Region: COG4925 446469005857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446469005858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446469005859 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446469005860 dimerization interface [polypeptide binding]; other site 446469005861 substrate binding pocket [chemical binding]; other site 446469005862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469005863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469005864 putative substrate translocation pore; other site 446469005865 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 446469005866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446469005867 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446469005868 dimerization interface [polypeptide binding]; other site 446469005869 substrate binding pocket [chemical binding]; other site 446469005870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469005871 Coenzyme A binding pocket [chemical binding]; other site 446469005872 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 446469005873 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446469005874 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446469005875 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 446469005876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469005877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469005878 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469005879 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469005880 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469005881 DNA binding site [nucleotide binding] 446469005882 domain linker motif; other site 446469005883 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469005884 ligand binding site [chemical binding]; other site 446469005885 dimerization interface [polypeptide binding]; other site 446469005886 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 446469005887 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446469005888 NADP binding site [chemical binding]; other site 446469005889 dimer interface [polypeptide binding]; other site 446469005890 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446469005891 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446469005892 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446469005893 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 446469005894 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446469005895 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446469005896 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446469005897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469005898 dimer interface [polypeptide binding]; other site 446469005899 conserved gate region; other site 446469005900 putative PBP binding loops; other site 446469005901 ABC-ATPase subunit interface; other site 446469005902 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469005903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469005904 dimer interface [polypeptide binding]; other site 446469005905 conserved gate region; other site 446469005906 ABC-ATPase subunit interface; other site 446469005907 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 446469005908 inhibitor binding site; inhibition site 446469005909 active site 446469005910 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 446469005911 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446469005912 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446469005913 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446469005914 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469005915 dimerization interface [polypeptide binding]; other site 446469005916 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469005917 dimer interface [polypeptide binding]; other site 446469005918 putative CheW interface [polypeptide binding]; other site 446469005919 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469005920 putative Zn2+ binding site [ion binding]; other site 446469005921 putative DNA binding site [nucleotide binding]; other site 446469005922 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446469005923 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446469005924 DNA polymerase IV; Provisional; Region: PRK03348 446469005925 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 446469005926 active site 446469005927 DNA binding site [nucleotide binding] 446469005928 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 446469005929 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 446469005930 dimerization interface [polypeptide binding]; other site 446469005931 ligand binding site [chemical binding]; other site 446469005932 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446469005933 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 446469005934 TM-ABC transporter signature motif; other site 446469005935 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446469005936 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 446469005937 TM-ABC transporter signature motif; other site 446469005938 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446469005939 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 446469005940 Walker A/P-loop; other site 446469005941 ATP binding site [chemical binding]; other site 446469005942 Q-loop/lid; other site 446469005943 ABC transporter signature motif; other site 446469005944 Walker B; other site 446469005945 D-loop; other site 446469005946 H-loop/switch region; other site 446469005947 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446469005948 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 446469005949 Walker A/P-loop; other site 446469005950 ATP binding site [chemical binding]; other site 446469005951 Q-loop/lid; other site 446469005952 ABC transporter signature motif; other site 446469005953 Walker B; other site 446469005954 D-loop; other site 446469005955 H-loop/switch region; other site 446469005956 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 446469005957 pyruvate kinase; Provisional; Region: PRK06247 446469005958 domain interfaces; other site 446469005959 active site 446469005960 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 446469005961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446469005962 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 446469005963 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 446469005964 active site 446469005965 dimer interface [polypeptide binding]; other site 446469005966 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 446469005967 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 446469005968 active site 446469005969 FMN binding site [chemical binding]; other site 446469005970 substrate binding site [chemical binding]; other site 446469005971 3Fe-4S cluster binding site [ion binding]; other site 446469005972 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 446469005973 domain interface; other site 446469005974 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 446469005975 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 446469005976 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 446469005977 substrate binding site [chemical binding]; other site 446469005978 active site 446469005979 catalytic residues [active] 446469005980 heterodimer interface [polypeptide binding]; other site 446469005981 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 446469005982 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 446469005983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469005984 catalytic residue [active] 446469005985 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 446469005986 active site 446469005987 ribulose/triose binding site [chemical binding]; other site 446469005988 phosphate binding site [ion binding]; other site 446469005989 substrate (anthranilate) binding pocket [chemical binding]; other site 446469005990 product (indole) binding pocket [chemical binding]; other site 446469005991 anthranilate synthase component I; Provisional; Region: PRK13571 446469005992 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 446469005993 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446469005994 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 446469005995 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446469005996 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469005997 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469005998 Walker A/P-loop; other site 446469005999 ATP binding site [chemical binding]; other site 446469006000 Q-loop/lid; other site 446469006001 ABC transporter signature motif; other site 446469006002 Walker B; other site 446469006003 D-loop; other site 446469006004 H-loop/switch region; other site 446469006005 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446469006006 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469006007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469006008 Walker A/P-loop; other site 446469006009 ATP binding site [chemical binding]; other site 446469006010 Q-loop/lid; other site 446469006011 ABC transporter signature motif; other site 446469006012 Walker B; other site 446469006013 D-loop; other site 446469006014 H-loop/switch region; other site 446469006015 TIGR03085 family protein; Region: TIGR03085 446469006016 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 446469006017 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 446469006018 substrate binding site [chemical binding]; other site 446469006019 glutamase interaction surface [polypeptide binding]; other site 446469006020 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446469006021 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 446469006022 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 446469006023 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 446469006024 active site 446469006025 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 446469006026 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 446469006027 active site 446469006028 Pup-like protein; Region: Pup; pfam05639 446469006029 Pup-ligase protein; Region: Pup_ligase; cl15463 446469006030 proteasome ATPase; Region: pup_AAA; TIGR03689 446469006031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469006032 Walker A motif; other site 446469006033 ATP binding site [chemical binding]; other site 446469006034 Walker B motif; other site 446469006035 arginine finger; other site 446469006036 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 446469006037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469006038 S-adenosylmethionine binding site [chemical binding]; other site 446469006039 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 446469006040 Peptidase family M50; Region: Peptidase_M50; pfam02163 446469006041 active site 446469006042 putative substrate binding region [chemical binding]; other site 446469006043 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446469006044 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 446469006045 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446469006046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469006047 motif II; other site 446469006048 PAC2 family; Region: PAC2; pfam09754 446469006049 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446469006050 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446469006051 DNA binding residues [nucleotide binding] 446469006052 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446469006053 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 446469006054 active site 446469006055 HIGH motif; other site 446469006056 nucleotide binding site [chemical binding]; other site 446469006057 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446469006058 active site 446469006059 KMSKS motif; other site 446469006060 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446469006061 tRNA binding surface [nucleotide binding]; other site 446469006062 anticodon binding site; other site 446469006063 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 446469006064 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 446469006065 oligomer interface [polypeptide binding]; other site 446469006066 putative Cl binding site [ion binding]; other site 446469006067 basic sphincter; other site 446469006068 hydrophobic gate; other site 446469006069 periplasmic entrance; other site 446469006070 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 446469006071 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469006072 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469006073 active site 446469006074 catalytic tetrad [active] 446469006075 hypothetical protein; Provisional; Region: PRK07906 446469006076 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 446469006077 putative metal binding site [ion binding]; other site 446469006078 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 446469006079 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 446469006080 active site 446469006081 Zn binding site [ion binding]; other site 446469006082 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 446469006083 hexamer interface [polypeptide binding]; other site 446469006084 ligand binding site [chemical binding]; other site 446469006085 putative active site [active] 446469006086 NAD(P) binding site [chemical binding]; other site 446469006087 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 446469006088 Domain of unknown function DUF20; Region: UPF0118; pfam01594 446469006089 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446469006090 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446469006091 acyl-activating enzyme (AAE) consensus motif; other site 446469006092 AMP binding site [chemical binding]; other site 446469006093 active site 446469006094 CoA binding site [chemical binding]; other site 446469006095 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446469006096 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 446469006097 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 446469006098 putative trimer interface [polypeptide binding]; other site 446469006099 putative CoA binding site [chemical binding]; other site 446469006100 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 446469006101 putative CoA binding site [chemical binding]; other site 446469006102 putative trimer interface [polypeptide binding]; other site 446469006103 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 446469006104 Peptidase family M1; Region: Peptidase_M1; pfam01433 446469006105 Zn binding site [ion binding]; other site 446469006106 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 446469006107 RibD C-terminal domain; Region: RibD_C; cl17279 446469006108 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469006109 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469006110 DNA binding site [nucleotide binding] 446469006111 domain linker motif; other site 446469006112 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469006113 ligand binding site [chemical binding]; other site 446469006114 dimerization interface [polypeptide binding]; other site 446469006115 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469006116 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469006117 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446469006118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469006119 dimer interface [polypeptide binding]; other site 446469006120 conserved gate region; other site 446469006121 putative PBP binding loops; other site 446469006122 ABC-ATPase subunit interface; other site 446469006123 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469006124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469006125 dimer interface [polypeptide binding]; other site 446469006126 conserved gate region; other site 446469006127 putative PBP binding loops; other site 446469006128 ABC-ATPase subunit interface; other site 446469006129 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 446469006130 inhibitor binding site; inhibition site 446469006131 active site 446469006132 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446469006133 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446469006134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469006135 DNA-binding site [nucleotide binding]; DNA binding site 446469006136 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 446469006137 active site 446469006138 dimer interfaces [polypeptide binding]; other site 446469006139 catalytic residues [active] 446469006140 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446469006141 DinB superfamily; Region: DinB_2; pfam12867 446469006142 LysE type translocator; Region: LysE; cl00565 446469006143 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 446469006144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446469006145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446469006146 dimerization interface [polypeptide binding]; other site 446469006147 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446469006148 Beta-lactamase; Region: Beta-lactamase; pfam00144 446469006149 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446469006150 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 446469006151 inhibitor site; inhibition site 446469006152 active site 446469006153 dimer interface [polypeptide binding]; other site 446469006154 catalytic residue [active] 446469006155 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 446469006156 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 446469006157 active site 446469006158 PHP Thumb interface [polypeptide binding]; other site 446469006159 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 446469006160 generic binding surface I; other site 446469006161 generic binding surface II; other site 446469006162 DNA Polymerase Y-family; Region: PolY_like; cd03468 446469006163 DNA binding site [nucleotide binding] 446469006164 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 446469006165 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 446469006166 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446469006167 putative ligand binding site [chemical binding]; other site 446469006168 putative NAD binding site [chemical binding]; other site 446469006169 catalytic site [active] 446469006170 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 446469006171 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446469006172 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446469006173 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469006174 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469006175 dimerization interface [polypeptide binding]; other site 446469006176 ligand binding site [chemical binding]; other site 446469006177 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 446469006178 substrate binding site [chemical binding]; other site 446469006179 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 446469006180 putative deacylase active site [active] 446469006181 tetracycline repressor protein TetR; Provisional; Region: PRK13756 446469006182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469006183 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446469006184 BioY family; Region: BioY; pfam02632 446469006185 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 446469006186 substrate binding site [chemical binding]; other site 446469006187 dimer interface [polypeptide binding]; other site 446469006188 ATP binding site [chemical binding]; other site 446469006189 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446469006190 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446469006191 dimer interface [polypeptide binding]; other site 446469006192 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446469006193 active site 446469006194 Shikimate kinase; Region: SKI; pfam01202 446469006195 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446469006196 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446469006197 FAD binding pocket [chemical binding]; other site 446469006198 FAD binding motif [chemical binding]; other site 446469006199 phosphate binding motif [ion binding]; other site 446469006200 NAD binding pocket [chemical binding]; other site 446469006201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469006202 Coenzyme A binding pocket [chemical binding]; other site 446469006203 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 446469006204 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446469006205 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469006206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469006207 ABC transporter; Region: ABC_tran_2; pfam12848 446469006208 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469006209 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 446469006210 ATP cone domain; Region: ATP-cone; pfam03477 446469006211 Class III ribonucleotide reductase; Region: RNR_III; cd01675 446469006212 effector binding site; other site 446469006213 active site 446469006214 Zn binding site [ion binding]; other site 446469006215 glycine loop; other site 446469006216 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 446469006217 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 446469006218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446469006219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446469006220 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 446469006221 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446469006222 Walker A/P-loop; other site 446469006223 ATP binding site [chemical binding]; other site 446469006224 Q-loop/lid; other site 446469006225 ABC transporter signature motif; other site 446469006226 Walker B; other site 446469006227 D-loop; other site 446469006228 H-loop/switch region; other site 446469006229 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446469006230 Uncharacterized conserved protein [Function unknown]; Region: COG1359 446469006231 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469006232 dimerization interface [polypeptide binding]; other site 446469006233 putative DNA binding site [nucleotide binding]; other site 446469006234 FtsX-like permease family; Region: FtsX; pfam02687 446469006235 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446469006236 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446469006237 Walker A/P-loop; other site 446469006238 ATP binding site [chemical binding]; other site 446469006239 Q-loop/lid; other site 446469006240 ABC transporter signature motif; other site 446469006241 Walker B; other site 446469006242 D-loop; other site 446469006243 H-loop/switch region; other site 446469006244 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469006245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469006246 active site 446469006247 phosphorylation site [posttranslational modification] 446469006248 intermolecular recognition site; other site 446469006249 dimerization interface [polypeptide binding]; other site 446469006250 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469006251 dimerization interface [polypeptide binding]; other site 446469006252 DNA binding residues [nucleotide binding] 446469006253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446469006254 Histidine kinase; Region: HisKA_3; pfam07730 446469006255 PemK-like protein; Region: PemK; cl00995 446469006256 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446469006257 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446469006258 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446469006259 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469006260 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 446469006261 Walker A/P-loop; other site 446469006262 ATP binding site [chemical binding]; other site 446469006263 Q-loop/lid; other site 446469006264 ABC transporter signature motif; other site 446469006265 Walker B; other site 446469006266 D-loop; other site 446469006267 H-loop/switch region; other site 446469006268 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446469006269 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469006270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469006271 Walker A/P-loop; other site 446469006272 ATP binding site [chemical binding]; other site 446469006273 Q-loop/lid; other site 446469006274 ABC transporter signature motif; other site 446469006275 Walker B; other site 446469006276 D-loop; other site 446469006277 H-loop/switch region; other site 446469006278 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 446469006279 HflK protein; Region: hflK; TIGR01933 446469006280 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446469006281 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446469006282 Walker A/P-loop; other site 446469006283 ATP binding site [chemical binding]; other site 446469006284 Q-loop/lid; other site 446469006285 ABC transporter signature motif; other site 446469006286 Walker B; other site 446469006287 D-loop; other site 446469006288 H-loop/switch region; other site 446469006289 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 446469006290 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446469006291 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 446469006292 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 446469006293 ligand binding site; other site 446469006294 oligomer interface; other site 446469006295 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 446469006296 dimer interface [polypeptide binding]; other site 446469006297 N-terminal domain interface [polypeptide binding]; other site 446469006298 sulfate 1 binding site; other site 446469006299 phosphoserine phosphatase SerB; Region: serB; TIGR00338 446469006300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469006301 motif II; other site 446469006302 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446469006303 catalytic core [active] 446469006304 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 446469006305 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 446469006306 NAD binding site [chemical binding]; other site 446469006307 homotetramer interface [polypeptide binding]; other site 446469006308 homodimer interface [polypeptide binding]; other site 446469006309 substrate binding site [chemical binding]; other site 446469006310 active site 446469006311 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 446469006312 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 446469006313 NAD(P) binding site [chemical binding]; other site 446469006314 homotetramer interface [polypeptide binding]; other site 446469006315 homodimer interface [polypeptide binding]; other site 446469006316 active site 446469006317 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 446469006318 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 446469006319 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469006320 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 446469006321 ATP binding site [chemical binding]; other site 446469006322 putative Mg++ binding site [ion binding]; other site 446469006323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469006324 nucleotide binding region [chemical binding]; other site 446469006325 ATP-binding site [chemical binding]; other site 446469006326 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446469006327 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469006328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469006329 Walker A/P-loop; other site 446469006330 ATP binding site [chemical binding]; other site 446469006331 Q-loop/lid; other site 446469006332 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469006333 ABC transporter signature motif; other site 446469006334 Walker B; other site 446469006335 D-loop; other site 446469006336 ABC transporter; Region: ABC_tran_2; pfam12848 446469006337 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469006338 BioY family; Region: BioY; pfam02632 446469006339 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446469006340 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446469006341 Walker A/P-loop; other site 446469006342 ATP binding site [chemical binding]; other site 446469006343 Q-loop/lid; other site 446469006344 ABC transporter signature motif; other site 446469006345 Walker B; other site 446469006346 D-loop; other site 446469006347 H-loop/switch region; other site 446469006348 Cobalt transport protein; Region: CbiQ; cl00463 446469006349 Nuclease-related domain; Region: NERD; pfam08378 446469006350 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 446469006351 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 446469006352 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 446469006353 trimerization site [polypeptide binding]; other site 446469006354 active site 446469006355 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446469006356 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 446469006357 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446469006358 catalytic residue [active] 446469006359 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 446469006360 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 446469006361 Walker A/P-loop; other site 446469006362 ATP binding site [chemical binding]; other site 446469006363 Q-loop/lid; other site 446469006364 ABC transporter signature motif; other site 446469006365 Walker B; other site 446469006366 D-loop; other site 446469006367 H-loop/switch region; other site 446469006368 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 446469006369 [2Fe-2S] cluster binding site [ion binding]; other site 446469006370 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 446469006371 FeS assembly protein SufD; Region: sufD; TIGR01981 446469006372 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 446469006373 FeS assembly protein SufB; Region: sufB; TIGR01980 446469006374 Predicted transcriptional regulator [Transcription]; Region: COG2345 446469006375 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469006376 putative DNA binding site [nucleotide binding]; other site 446469006377 putative Zn2+ binding site [ion binding]; other site 446469006378 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446469006379 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446469006380 Walker A/P-loop; other site 446469006381 ATP binding site [chemical binding]; other site 446469006382 Q-loop/lid; other site 446469006383 ABC transporter signature motif; other site 446469006384 Walker B; other site 446469006385 D-loop; other site 446469006386 H-loop/switch region; other site 446469006387 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446469006388 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 446469006389 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 446469006390 active site 446469006391 phosphate binding residues; other site 446469006392 catalytic residues [active] 446469006393 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446469006394 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446469006395 Predicted ATPase [General function prediction only]; Region: COG3903 446469006396 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446469006397 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446469006398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469006399 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446469006400 Walker A/P-loop; other site 446469006401 ATP binding site [chemical binding]; other site 446469006402 Q-loop/lid; other site 446469006403 ABC transporter signature motif; other site 446469006404 Walker B; other site 446469006405 D-loop; other site 446469006406 H-loop/switch region; other site 446469006407 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 446469006408 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 446469006409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469006410 putative substrate translocation pore; other site 446469006411 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 446469006412 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446469006413 dimer interface [polypeptide binding]; other site 446469006414 active site 446469006415 ADP-ribose binding site [chemical binding]; other site 446469006416 nudix motif; other site 446469006417 metal binding site [ion binding]; metal-binding site 446469006418 CTP synthetase; Validated; Region: pyrG; PRK05380 446469006419 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 446469006420 Catalytic site [active] 446469006421 active site 446469006422 UTP binding site [chemical binding]; other site 446469006423 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 446469006424 active site 446469006425 putative oxyanion hole; other site 446469006426 catalytic triad [active] 446469006427 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 446469006428 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446469006429 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446469006430 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 446469006431 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 446469006432 Thiamine pyrophosphokinase; Region: TPK; cl08415 446469006433 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 446469006434 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 446469006435 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 446469006436 Walker A/P-loop; other site 446469006437 ATP binding site [chemical binding]; other site 446469006438 Q-loop/lid; other site 446469006439 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 446469006440 ABC transporter signature motif; other site 446469006441 Walker B; other site 446469006442 D-loop; other site 446469006443 H-loop/switch region; other site 446469006444 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 446469006445 ATP-NAD kinase; Region: NAD_kinase; pfam01513 446469006446 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 446469006447 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446469006448 RNA binding surface [nucleotide binding]; other site 446469006449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469006450 S-adenosylmethionine binding site [chemical binding]; other site 446469006451 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 446469006452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469006453 active site 446469006454 motif I; other site 446469006455 motif II; other site 446469006456 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 446469006457 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 446469006458 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 446469006459 active site 446469006460 HIGH motif; other site 446469006461 dimer interface [polypeptide binding]; other site 446469006462 KMSKS motif; other site 446469006463 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 446469006464 active site 446469006465 DNA binding site [nucleotide binding] 446469006466 hypothetical protein; Provisional; Region: PRK06547 446469006467 AAA domain; Region: AAA_18; pfam13238 446469006468 argininosuccinate lyase; Provisional; Region: PRK00855 446469006469 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 446469006470 active sites [active] 446469006471 tetramer interface [polypeptide binding]; other site 446469006472 argininosuccinate synthase; Provisional; Region: PRK13820 446469006473 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 446469006474 ANP binding site [chemical binding]; other site 446469006475 Substrate Binding Site II [chemical binding]; other site 446469006476 Substrate Binding Site I [chemical binding]; other site 446469006477 arginine repressor; Provisional; Region: PRK03341 446469006478 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 446469006479 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 446469006480 ornithine carbamoyltransferase; Provisional; Region: PRK00779 446469006481 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446469006482 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 446469006483 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 446469006484 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446469006485 inhibitor-cofactor binding pocket; inhibition site 446469006486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469006487 catalytic residue [active] 446469006488 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 446469006489 feedback inhibition sensing region; other site 446469006490 homohexameric interface [polypeptide binding]; other site 446469006491 nucleotide binding site [chemical binding]; other site 446469006492 N-acetyl-L-glutamate binding site [chemical binding]; other site 446469006493 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 446469006494 heterotetramer interface [polypeptide binding]; other site 446469006495 active site pocket [active] 446469006496 cleavage site 446469006497 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 446469006498 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 446469006499 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 446469006500 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446469006501 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 446469006502 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 446469006503 NADP binding site [chemical binding]; other site 446469006504 dimer interface [polypeptide binding]; other site 446469006505 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 446469006506 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 446469006507 putative tRNA-binding site [nucleotide binding]; other site 446469006508 B3/4 domain; Region: B3_4; pfam03483 446469006509 tRNA synthetase B5 domain; Region: B5; smart00874 446469006510 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 446469006511 dimer interface [polypeptide binding]; other site 446469006512 motif 1; other site 446469006513 motif 3; other site 446469006514 motif 2; other site 446469006515 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 446469006516 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 446469006517 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 446469006518 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 446469006519 dimer interface [polypeptide binding]; other site 446469006520 motif 1; other site 446469006521 active site 446469006522 motif 2; other site 446469006523 motif 3; other site 446469006524 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 446469006525 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 446469006526 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446469006527 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 446469006528 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446469006529 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 446469006530 23S rRNA binding site [nucleotide binding]; other site 446469006531 L21 binding site [polypeptide binding]; other site 446469006532 L13 binding site [polypeptide binding]; other site 446469006533 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 446469006534 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 446469006535 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 446469006536 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 446469006537 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446469006538 metal binding site 2 [ion binding]; metal-binding site 446469006539 putative DNA binding helix; other site 446469006540 metal binding site 1 [ion binding]; metal-binding site 446469006541 dimer interface [polypeptide binding]; other site 446469006542 structural Zn2+ binding site [ion binding]; other site 446469006543 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 446469006544 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 446469006545 tetramer interface [polypeptide binding]; other site 446469006546 heme binding pocket [chemical binding]; other site 446469006547 NADPH binding site [chemical binding]; other site 446469006548 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 446469006549 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446469006550 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 446469006551 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 446469006552 catalytic residues [active] 446469006553 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 446469006554 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 446469006555 putative active site [active] 446469006556 oxyanion strand; other site 446469006557 catalytic triad [active] 446469006558 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 446469006559 putative active site pocket [active] 446469006560 4-fold oligomerization interface [polypeptide binding]; other site 446469006561 metal binding residues [ion binding]; metal-binding site 446469006562 3-fold/trimer interface [polypeptide binding]; other site 446469006563 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 446469006564 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446469006565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469006566 homodimer interface [polypeptide binding]; other site 446469006567 catalytic residue [active] 446469006568 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 446469006569 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469006570 ATP binding site [chemical binding]; other site 446469006571 putative Mg++ binding site [ion binding]; other site 446469006572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469006573 nucleotide binding region [chemical binding]; other site 446469006574 ATP-binding site [chemical binding]; other site 446469006575 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; pfam01184 446469006576 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 446469006577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446469006578 putative active site [active] 446469006579 heme pocket [chemical binding]; other site 446469006580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469006581 dimer interface [polypeptide binding]; other site 446469006582 phosphorylation site [posttranslational modification] 446469006583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469006584 ATP binding site [chemical binding]; other site 446469006585 Mg2+ binding site [ion binding]; other site 446469006586 G-X-G motif; other site 446469006587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469006588 Response regulator receiver domain; Region: Response_reg; pfam00072 446469006589 active site 446469006590 phosphorylation site [posttranslational modification] 446469006591 intermolecular recognition site; other site 446469006592 dimerization interface [polypeptide binding]; other site 446469006593 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446469006594 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 446469006595 DXD motif; other site 446469006596 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 446469006597 active site 446469006598 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 446469006599 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446469006600 Response regulator receiver domain; Region: Response_reg; pfam00072 446469006601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469006602 active site 446469006603 phosphorylation site [posttranslational modification] 446469006604 intermolecular recognition site; other site 446469006605 dimerization interface [polypeptide binding]; other site 446469006606 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 446469006607 histidinol dehydrogenase; Region: hisD; TIGR00069 446469006608 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 446469006609 NAD binding site [chemical binding]; other site 446469006610 dimerization interface [polypeptide binding]; other site 446469006611 product binding site; other site 446469006612 substrate binding site [chemical binding]; other site 446469006613 zinc binding site [ion binding]; other site 446469006614 catalytic residues [active] 446469006615 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446469006616 RNA binding surface [nucleotide binding]; other site 446469006617 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 446469006618 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 446469006619 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 446469006620 active site 446469006621 PHP Thumb interface [polypeptide binding]; other site 446469006622 metal binding site [ion binding]; metal-binding site 446469006623 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 446469006624 generic binding surface II; other site 446469006625 generic binding surface I; other site 446469006626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469006627 Coenzyme A binding pocket [chemical binding]; other site 446469006628 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 446469006629 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446469006630 RNA binding surface [nucleotide binding]; other site 446469006631 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 446469006632 active site 446469006633 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 446469006634 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 446469006635 Protein of unknown function (DUF552); Region: DUF552; cl00775 446469006636 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 446469006637 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 446469006638 cell division protein FtsZ; Validated; Region: PRK09330 446469006639 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 446469006640 nucleotide binding site [chemical binding]; other site 446469006641 SulA interaction site; other site 446469006642 cell division protein FtsQ; Provisional; Region: PRK05529 446469006643 Cell division protein FtsQ; Region: FtsQ; pfam03799 446469006644 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 446469006645 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446469006646 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446469006647 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446469006648 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 446469006649 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 446469006650 active site 446469006651 homodimer interface [polypeptide binding]; other site 446469006652 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 446469006653 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 446469006654 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446469006655 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 446469006656 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 446469006657 Mg++ binding site [ion binding]; other site 446469006658 putative catalytic motif [active] 446469006659 putative substrate binding site [chemical binding]; other site 446469006660 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 446469006661 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446469006662 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446469006663 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 446469006664 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446469006665 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446469006666 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 446469006667 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446469006668 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446469006669 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 446469006670 MraW methylase family; Region: Methyltransf_5; pfam01795 446469006671 MraZ protein; Region: MraZ; pfam02381 446469006672 cell division protein MraZ; Reviewed; Region: PRK00326 446469006673 MraZ protein; Region: MraZ; pfam02381 446469006674 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 446469006675 DNA polymerase IV; Validated; Region: PRK03858 446469006676 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 446469006677 active site 446469006678 DNA binding site [nucleotide binding] 446469006679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469006680 S-adenosylmethionine binding site [chemical binding]; other site 446469006681 PAC2 family; Region: PAC2; pfam09754 446469006682 Response regulator receiver domain; Region: Response_reg; pfam00072 446469006683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469006684 active site 446469006685 phosphorylation site [posttranslational modification] 446469006686 intermolecular recognition site; other site 446469006687 dimerization interface [polypeptide binding]; other site 446469006688 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469006689 dimerization interface [polypeptide binding]; other site 446469006690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469006691 dimer interface [polypeptide binding]; other site 446469006692 phosphorylation site [posttranslational modification] 446469006693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469006694 ATP binding site [chemical binding]; other site 446469006695 Mg2+ binding site [ion binding]; other site 446469006696 G-X-G motif; other site 446469006697 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 446469006698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469006699 active site 446469006700 phosphorylation site [posttranslational modification] 446469006701 intermolecular recognition site; other site 446469006702 dimerization interface [polypeptide binding]; other site 446469006703 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446469006704 Part of AAA domain; Region: AAA_19; pfam13245 446469006705 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 446469006706 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 446469006707 ligand binding site [chemical binding]; other site 446469006708 NAD binding site [chemical binding]; other site 446469006709 tetramer interface [polypeptide binding]; other site 446469006710 catalytic site [active] 446469006711 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 446469006712 L-serine binding site [chemical binding]; other site 446469006713 ACT domain interface; other site 446469006714 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469006715 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469006716 active site 446469006717 catalytic tetrad [active] 446469006718 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 446469006719 ATP cone domain; Region: ATP-cone; pfam03477 446469006720 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 446469006721 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 446469006722 LexA repressor; Validated; Region: PRK00215 446469006723 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 446469006724 Catalytic site [active] 446469006725 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 446469006726 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 446469006727 dimer interface [polypeptide binding]; other site 446469006728 NAD binding site [chemical binding]; other site 446469006729 substrate binding site [chemical binding]; other site 446469006730 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446469006731 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 446469006732 DEAD/DEAH box helicase; Region: DEAD; pfam00270 446469006733 ATP binding site [chemical binding]; other site 446469006734 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 446469006735 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 446469006736 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 446469006737 HflX GTPase family; Region: HflX; cd01878 446469006738 G1 box; other site 446469006739 GTP/Mg2+ binding site [chemical binding]; other site 446469006740 Switch I region; other site 446469006741 G2 box; other site 446469006742 G3 box; other site 446469006743 Switch II region; other site 446469006744 G4 box; other site 446469006745 G5 box; other site 446469006746 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 446469006747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469006748 S-adenosylmethionine binding site [chemical binding]; other site 446469006749 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 446469006750 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 446469006751 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 446469006752 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 446469006753 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 446469006754 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 446469006755 HSP90 family protein; Provisional; Region: PRK14083 446469006756 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 446469006757 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 446469006758 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 446469006759 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 446469006760 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446469006761 FeS/SAM binding site; other site 446469006762 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 446469006763 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446469006764 Zn2+ binding site [ion binding]; other site 446469006765 Mg2+ binding site [ion binding]; other site 446469006766 recombination regulator RecX; Reviewed; Region: recX; PRK00117 446469006767 recombinase A; Provisional; Region: recA; PRK09354 446469006768 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 446469006769 hexamer interface [polypeptide binding]; other site 446469006770 Walker A motif; other site 446469006771 ATP binding site [chemical binding]; other site 446469006772 Walker B motif; other site 446469006773 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 446469006774 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469006775 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 446469006776 ATP binding site [chemical binding]; other site 446469006777 putative Mg++ binding site [ion binding]; other site 446469006778 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469006779 nucleotide binding region [chemical binding]; other site 446469006780 ATP-binding site [chemical binding]; other site 446469006781 DEAD/H associated; Region: DEAD_assoc; pfam08494 446469006782 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 446469006783 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 446469006784 putative DNA binding site [nucleotide binding]; other site 446469006785 catalytic residue [active] 446469006786 putative H2TH interface [polypeptide binding]; other site 446469006787 putative catalytic residues [active] 446469006788 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446469006789 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446469006790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469006791 non-specific DNA binding site [nucleotide binding]; other site 446469006792 salt bridge; other site 446469006793 sequence-specific DNA binding site [nucleotide binding]; other site 446469006794 Competence-damaged protein; Region: CinA; pfam02464 446469006795 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 446469006796 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 446469006797 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446469006798 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 446469006799 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 446469006800 dihydrodipicolinate synthase; Region: dapA; TIGR00674 446469006801 dimer interface [polypeptide binding]; other site 446469006802 active site 446469006803 catalytic residue [active] 446469006804 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446469006805 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 446469006806 folate binding site [chemical binding]; other site 446469006807 NADP+ binding site [chemical binding]; other site 446469006808 thymidylate synthase; Reviewed; Region: thyA; PRK01827 446469006809 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 446469006810 dimerization interface [polypeptide binding]; other site 446469006811 active site 446469006812 succinic semialdehyde dehydrogenase; Region: PLN02278 446469006813 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 446469006814 tetramerization interface [polypeptide binding]; other site 446469006815 NAD(P) binding site [chemical binding]; other site 446469006816 catalytic residues [active] 446469006817 dihydrodipicolinate reductase; Provisional; Region: PRK00048 446469006818 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 446469006819 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 446469006820 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446469006821 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 446469006822 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446469006823 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 446469006824 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 446469006825 oligomer interface [polypeptide binding]; other site 446469006826 RNA binding site [nucleotide binding]; other site 446469006827 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 446469006828 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 446469006829 RNase E interface [polypeptide binding]; other site 446469006830 trimer interface [polypeptide binding]; other site 446469006831 active site 446469006832 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 446469006833 putative nucleic acid binding region [nucleotide binding]; other site 446469006834 G-X-X-G motif; other site 446469006835 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 446469006836 RNA binding site [nucleotide binding]; other site 446469006837 domain interface; other site 446469006838 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 446469006839 16S/18S rRNA binding site [nucleotide binding]; other site 446469006840 S13e-L30e interaction site [polypeptide binding]; other site 446469006841 25S rRNA binding site [nucleotide binding]; other site 446469006842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469006843 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 446469006844 Walker A/P-loop; other site 446469006845 ATP binding site [chemical binding]; other site 446469006846 Q-loop/lid; other site 446469006847 ABC transporter signature motif; other site 446469006848 Walker B; other site 446469006849 D-loop; other site 446469006850 H-loop/switch region; other site 446469006851 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 446469006852 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 446469006853 active site 446469006854 Riboflavin kinase; Region: Flavokinase; smart00904 446469006855 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 446469006856 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 446469006857 RNA binding site [nucleotide binding]; other site 446469006858 active site 446469006859 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 446469006860 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 446469006861 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446469006862 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 446469006863 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 446469006864 G1 box; other site 446469006865 putative GEF interaction site [polypeptide binding]; other site 446469006866 GTP/Mg2+ binding site [chemical binding]; other site 446469006867 Switch I region; other site 446469006868 G2 box; other site 446469006869 G3 box; other site 446469006870 Switch II region; other site 446469006871 G4 box; other site 446469006872 G5 box; other site 446469006873 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 446469006874 Translation-initiation factor 2; Region: IF-2; pfam11987 446469006875 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 446469006876 Protein of unknown function (DUF448); Region: DUF448; pfam04296 446469006877 putative RNA binding cleft [nucleotide binding]; other site 446469006878 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 446469006879 NusA N-terminal domain; Region: NusA_N; pfam08529 446469006880 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 446469006881 RNA binding site [nucleotide binding]; other site 446469006882 homodimer interface [polypeptide binding]; other site 446469006883 NusA-like KH domain; Region: KH_5; pfam13184 446469006884 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 446469006885 G-X-X-G motif; other site 446469006886 Sm and related proteins; Region: Sm_like; cl00259 446469006887 ribosome maturation protein RimP; Reviewed; Region: PRK00092 446469006888 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 446469006889 putative oligomer interface [polypeptide binding]; other site 446469006890 putative RNA binding site [nucleotide binding]; other site 446469006891 prolyl-tRNA synthetase; Provisional; Region: PRK09194 446469006892 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 446469006893 dimer interface [polypeptide binding]; other site 446469006894 motif 1; other site 446469006895 active site 446469006896 motif 2; other site 446469006897 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 446469006898 putative deacylase active site [active] 446469006899 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446469006900 active site 446469006901 motif 3; other site 446469006902 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 446469006903 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 446469006904 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446469006905 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 446469006906 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 446469006907 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 446469006908 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 446469006909 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 446469006910 active site 446469006911 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 446469006912 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 446469006913 putative substrate binding region [chemical binding]; other site 446469006914 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 446469006915 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 446469006916 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 446469006917 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 446469006918 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 446469006919 DivIVA domain; Region: DivI1A_domain; TIGR03544 446469006920 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 446469006921 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446469006922 FeS/SAM binding site; other site 446469006923 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 446469006924 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 446469006925 ribosome recycling factor; Reviewed; Region: frr; PRK00083 446469006926 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 446469006927 hinge region; other site 446469006928 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 446469006929 putative nucleotide binding site [chemical binding]; other site 446469006930 uridine monophosphate binding site [chemical binding]; other site 446469006931 homohexameric interface [polypeptide binding]; other site 446469006932 elongation factor Ts; Provisional; Region: tsf; PRK09377 446469006933 UBA/TS-N domain; Region: UBA; pfam00627 446469006934 Elongation factor TS; Region: EF_TS; pfam00889 446469006935 Elongation factor TS; Region: EF_TS; pfam00889 446469006936 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 446469006937 rRNA interaction site [nucleotide binding]; other site 446469006938 S8 interaction site; other site 446469006939 putative laminin-1 binding site; other site 446469006940 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 446469006941 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469006942 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446469006943 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469006944 DNA binding residues [nucleotide binding] 446469006945 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 446469006946 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446469006947 active site 446469006948 DNA binding site [nucleotide binding] 446469006949 Int/Topo IB signature motif; other site 446469006950 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 446469006951 DNA protecting protein DprA; Region: dprA; TIGR00732 446469006952 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 446469006953 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 446469006954 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 446469006955 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 446469006956 hypothetical protein; Reviewed; Region: PRK12497 446469006957 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 446469006958 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 446469006959 RNA/DNA hybrid binding site [nucleotide binding]; other site 446469006960 active site 446469006961 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 446469006962 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446469006963 Catalytic site [active] 446469006964 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 446469006965 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 446469006966 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 446469006967 RimM N-terminal domain; Region: RimM; pfam01782 446469006968 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 446469006969 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 446469006970 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446469006971 Amidohydrolase; Region: Amidohydro_4; pfam13147 446469006972 active site 446469006973 signal recognition particle protein; Provisional; Region: PRK10867 446469006974 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 446469006975 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 446469006976 P loop; other site 446469006977 GTP binding site [chemical binding]; other site 446469006978 Signal peptide binding domain; Region: SRP_SPB; pfam02978 446469006979 PII uridylyl-transferase; Provisional; Region: PRK03381 446469006980 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446469006981 metal binding triad; other site 446469006982 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446469006983 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 446469006984 Nitrogen regulatory protein P-II; Region: P-II; smart00938 446469006985 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 446469006986 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 446469006987 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446469006988 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 446469006989 AAA domain; Region: AAA_23; pfam13476 446469006990 Walker A/P-loop; other site 446469006991 ATP binding site [chemical binding]; other site 446469006992 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 446469006993 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 446469006994 ABC transporter signature motif; other site 446469006995 Walker B; other site 446469006996 D-loop; other site 446469006997 H-loop/switch region; other site 446469006998 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 446469006999 active site 446469007000 multimer interface [polypeptide binding]; other site 446469007001 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 446469007002 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446469007003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469007004 putative substrate translocation pore; other site 446469007005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469007006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469007007 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446469007008 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 446469007009 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 446469007010 dimerization domain swap beta strand [polypeptide binding]; other site 446469007011 regulatory protein interface [polypeptide binding]; other site 446469007012 active site 446469007013 regulatory phosphorylation site [posttranslational modification]; other site 446469007014 DAK2 domain; Region: Dak2; cl03685 446469007015 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 446469007016 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 446469007017 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 446469007018 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446469007019 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446469007020 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 446469007021 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446469007022 HIGH motif; other site 446469007023 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446469007024 active site 446469007025 KMSKS motif; other site 446469007026 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 446469007027 tRNA binding surface [nucleotide binding]; other site 446469007028 anticodon binding site; other site 446469007029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469007030 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 446469007031 NAD(P) binding site [chemical binding]; other site 446469007032 active site 446469007033 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 446469007034 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 446469007035 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446469007036 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 446469007037 intersubunit interface [polypeptide binding]; other site 446469007038 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446469007039 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446469007040 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469007041 dimer interface [polypeptide binding]; other site 446469007042 putative PBP binding regions; other site 446469007043 ABC-ATPase subunit interface; other site 446469007044 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 446469007045 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446469007046 Walker A/P-loop; other site 446469007047 ATP binding site [chemical binding]; other site 446469007048 Q-loop/lid; other site 446469007049 ABC transporter signature motif; other site 446469007050 Walker B; other site 446469007051 D-loop; other site 446469007052 H-loop/switch region; other site 446469007053 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446469007054 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446469007055 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 446469007056 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 446469007057 putative dimer interface [polypeptide binding]; other site 446469007058 N-terminal domain interface [polypeptide binding]; other site 446469007059 putative substrate binding pocket (H-site) [chemical binding]; other site 446469007060 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446469007061 minor groove reading motif; other site 446469007062 helix-hairpin-helix signature motif; other site 446469007063 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446469007064 Family description; Region: UvrD_C_2; pfam13538 446469007065 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 446469007066 Part of AAA domain; Region: AAA_19; pfam13245 446469007067 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 446469007068 AAA domain; Region: AAA_12; pfam13087 446469007069 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 446469007070 putative active site [active] 446469007071 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 446469007072 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 446469007073 phosphate binding site [ion binding]; other site 446469007074 dimer interface [polypeptide binding]; other site 446469007075 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446469007076 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 446469007077 DNA binding residues [nucleotide binding] 446469007078 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446469007079 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 446469007080 DNA binding residues [nucleotide binding] 446469007081 putative dimer interface [polypeptide binding]; other site 446469007082 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446469007083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469007084 putative substrate translocation pore; other site 446469007085 Guanylyl transferase CofC like; Region: CofC; cl17472 446469007086 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 446469007087 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 446469007088 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 446469007089 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446469007090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469007091 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 446469007092 NAD(P) binding site [chemical binding]; other site 446469007093 active site 446469007094 hypothetical protein; Provisional; Region: PRK06062 446469007095 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446469007096 inhibitor-cofactor binding pocket; inhibition site 446469007097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469007098 catalytic residue [active] 446469007099 NMT1/THI5 like; Region: NMT1; pfam09084 446469007100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 446469007101 substrate binding pocket [chemical binding]; other site 446469007102 membrane-bound complex binding site; other site 446469007103 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446469007104 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446469007105 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446469007106 Walker A/P-loop; other site 446469007107 ATP binding site [chemical binding]; other site 446469007108 Q-loop/lid; other site 446469007109 ABC transporter signature motif; other site 446469007110 Walker B; other site 446469007111 D-loop; other site 446469007112 H-loop/switch region; other site 446469007113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446469007114 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446469007115 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 446469007116 phenylhydantoinase; Validated; Region: PRK08323 446469007117 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 446469007118 tetramer interface [polypeptide binding]; other site 446469007119 active site 446469007120 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 446469007121 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 446469007122 active site 446469007123 catalytic triad [active] 446469007124 dimer interface [polypeptide binding]; other site 446469007125 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 446469007126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469007127 DNA-binding site [nucleotide binding]; DNA binding site 446469007128 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446469007129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469007130 homodimer interface [polypeptide binding]; other site 446469007131 catalytic residue [active] 446469007132 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446469007133 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469007134 Walker A/P-loop; other site 446469007135 ATP binding site [chemical binding]; other site 446469007136 Q-loop/lid; other site 446469007137 ABC transporter signature motif; other site 446469007138 Walker B; other site 446469007139 D-loop; other site 446469007140 H-loop/switch region; other site 446469007141 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469007142 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469007143 Walker A/P-loop; other site 446469007144 ATP binding site [chemical binding]; other site 446469007145 Q-loop/lid; other site 446469007146 ABC transporter signature motif; other site 446469007147 Walker B; other site 446469007148 D-loop; other site 446469007149 H-loop/switch region; other site 446469007150 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469007151 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 446469007152 peptide binding site [polypeptide binding]; other site 446469007153 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446469007154 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446469007155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469007156 dimer interface [polypeptide binding]; other site 446469007157 conserved gate region; other site 446469007158 putative PBP binding loops; other site 446469007159 ABC-ATPase subunit interface; other site 446469007160 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446469007161 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446469007162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469007163 dimer interface [polypeptide binding]; other site 446469007164 conserved gate region; other site 446469007165 putative PBP binding loops; other site 446469007166 ABC-ATPase subunit interface; other site 446469007167 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 446469007168 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446469007169 active site 446469007170 HIGH motif; other site 446469007171 nucleotide binding site [chemical binding]; other site 446469007172 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446469007173 active site 446469007174 KMSKS motif; other site 446469007175 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 446469007176 tRNA binding surface [nucleotide binding]; other site 446469007177 anticodon binding site; other site 446469007178 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446469007179 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 446469007180 acyl-activating enzyme (AAE) consensus motif; other site 446469007181 putative AMP binding site [chemical binding]; other site 446469007182 putative active site [active] 446469007183 putative CoA binding site [chemical binding]; other site 446469007184 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446469007185 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446469007186 substrate binding pocket [chemical binding]; other site 446469007187 membrane-bound complex binding site; other site 446469007188 hinge residues; other site 446469007189 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446469007190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469007191 dimer interface [polypeptide binding]; other site 446469007192 conserved gate region; other site 446469007193 putative PBP binding loops; other site 446469007194 ABC-ATPase subunit interface; other site 446469007195 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446469007196 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446469007197 Walker A/P-loop; other site 446469007198 ATP binding site [chemical binding]; other site 446469007199 Q-loop/lid; other site 446469007200 ABC transporter signature motif; other site 446469007201 Walker B; other site 446469007202 D-loop; other site 446469007203 H-loop/switch region; other site 446469007204 chorismate mutase; Provisional; Region: PRK09239 446469007205 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 446469007206 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 446469007207 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 446469007208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469007209 Walker A motif; other site 446469007210 ATP binding site [chemical binding]; other site 446469007211 Walker B motif; other site 446469007212 arginine finger; other site 446469007213 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 446469007214 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 446469007215 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446469007216 oligomer interface [polypeptide binding]; other site 446469007217 active site residues [active] 446469007218 Clp protease; Region: CLP_protease; pfam00574 446469007219 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446469007220 oligomer interface [polypeptide binding]; other site 446469007221 active site residues [active] 446469007222 trigger factor; Provisional; Region: tig; PRK01490 446469007223 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446469007224 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 446469007225 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446469007226 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446469007227 dimer interface [polypeptide binding]; other site 446469007228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469007229 catalytic residue [active] 446469007230 serine O-acetyltransferase; Region: cysE; TIGR01172 446469007231 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 446469007232 trimer interface [polypeptide binding]; other site 446469007233 active site 446469007234 substrate binding site [chemical binding]; other site 446469007235 CoA binding site [chemical binding]; other site 446469007236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469007237 DNA-binding site [nucleotide binding]; DNA binding site 446469007238 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446469007239 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 446469007240 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446469007241 active site 446469007242 DNA binding site [nucleotide binding] 446469007243 hypothetical protein; Provisional; Region: PRK01346 446469007244 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 446469007245 Coenzyme A binding pocket [chemical binding]; other site 446469007246 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 446469007247 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 446469007248 DNA binding site [nucleotide binding] 446469007249 catalytic residue [active] 446469007250 H2TH interface [polypeptide binding]; other site 446469007251 putative catalytic residues [active] 446469007252 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446469007253 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446469007254 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 446469007255 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 446469007256 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 446469007257 active site 446469007258 Zn binding site [ion binding]; other site 446469007259 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 446469007260 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446469007261 active site 446469007262 catalytic site [active] 446469007263 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 446469007264 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446469007265 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 446469007266 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 446469007267 Zn binding site [ion binding]; other site 446469007268 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 446469007269 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 446469007270 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 446469007271 Mechanosensitive ion channel; Region: MS_channel; pfam00924 446469007272 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 446469007273 HPr interaction site; other site 446469007274 glycerol kinase (GK) interaction site [polypeptide binding]; other site 446469007275 active site 446469007276 phosphorylation site [posttranslational modification] 446469007277 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 446469007278 active site turn [active] 446469007279 phosphorylation site [posttranslational modification] 446469007280 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 446469007281 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446469007282 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 446469007283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469007284 Coenzyme A binding pocket [chemical binding]; other site 446469007285 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 446469007286 apolar tunnel; other site 446469007287 heme binding site [chemical binding]; other site 446469007288 dimerization interface [polypeptide binding]; other site 446469007289 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 446469007290 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 446469007291 active site 446469007292 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 446469007293 catalytic triad [active] 446469007294 dimer interface [polypeptide binding]; other site 446469007295 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 446469007296 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 446469007297 active site 446469007298 DNA binding site [nucleotide binding] 446469007299 Int/Topo IB signature motif; other site 446469007300 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446469007301 active site 446469007302 Dynamin family; Region: Dynamin_N; pfam00350 446469007303 YfjP GTPase; Region: YfjP; cd11383 446469007304 G1 box; other site 446469007305 GTP/Mg2+ binding site [chemical binding]; other site 446469007306 Switch I region; other site 446469007307 G2 box; other site 446469007308 Switch II region; other site 446469007309 G3 box; other site 446469007310 G4 box; other site 446469007311 G5 box; other site 446469007312 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446469007313 G1 box; other site 446469007314 GTP/Mg2+ binding site [chemical binding]; other site 446469007315 G2 box; other site 446469007316 Switch I region; other site 446469007317 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 446469007318 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469007319 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469007320 ABC transporter; Region: ABC_tran_2; pfam12848 446469007321 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469007322 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 446469007323 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446469007324 dimer interface [polypeptide binding]; other site 446469007325 ssDNA binding site [nucleotide binding]; other site 446469007326 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446469007327 YfjP GTPase; Region: YfjP; cd11383 446469007328 G1 box; other site 446469007329 GTP/Mg2+ binding site [chemical binding]; other site 446469007330 Switch I region; other site 446469007331 G2 box; other site 446469007332 Switch II region; other site 446469007333 G3 box; other site 446469007334 G4 box; other site 446469007335 G5 box; other site 446469007336 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446469007337 G1 box; other site 446469007338 GTP/Mg2+ binding site [chemical binding]; other site 446469007339 G2 box; other site 446469007340 Switch I region; other site 446469007341 G3 box; other site 446469007342 Switch II region; other site 446469007343 G4 box; other site 446469007344 G5 box; other site 446469007345 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 446469007346 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 446469007347 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 446469007348 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446469007349 metal ion-dependent adhesion site (MIDAS); other site 446469007350 Domain of unknown function DUF11; Region: DUF11; cl17728 446469007351 Divergent AAA domain; Region: AAA_4; pfam04326 446469007352 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 446469007353 RNA/DNA hybrid binding site [nucleotide binding]; other site 446469007354 active site 446469007355 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446469007356 active site 446469007357 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 446469007358 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 446469007359 active site 446469007360 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 446469007361 catalytic site [active] 446469007362 putative active site [active] 446469007363 putative substrate binding site [chemical binding]; other site 446469007364 dimer interface [polypeptide binding]; other site 446469007365 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 446469007366 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446469007367 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 446469007368 catalytic triad [active] 446469007369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469007370 S-adenosylmethionine binding site [chemical binding]; other site 446469007371 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446469007372 catalytic residues [active] 446469007373 Predicted membrane protein [Function unknown]; Region: COG2311 446469007374 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446469007375 Predicted membrane protein [Function unknown]; Region: COG2311 446469007376 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446469007377 Predicted membrane protein [Function unknown]; Region: COG2311 446469007378 Protein of unknown function (DUF418); Region: DUF418; cl12135 446469007379 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446469007380 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469007381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469007382 active site 446469007383 phosphorylation site [posttranslational modification] 446469007384 intermolecular recognition site; other site 446469007385 dimerization interface [polypeptide binding]; other site 446469007386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469007387 DNA binding residues [nucleotide binding] 446469007388 dimerization interface [polypeptide binding]; other site 446469007389 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446469007390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469007391 Walker A/P-loop; other site 446469007392 ATP binding site [chemical binding]; other site 446469007393 Q-loop/lid; other site 446469007394 ABC transporter signature motif; other site 446469007395 Walker B; other site 446469007396 D-loop; other site 446469007397 H-loop/switch region; other site 446469007398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469007399 Walker A/P-loop; other site 446469007400 ATP binding site [chemical binding]; other site 446469007401 Q-loop/lid; other site 446469007402 ABC transporter signature motif; other site 446469007403 Walker B; other site 446469007404 D-loop; other site 446469007405 H-loop/switch region; other site 446469007406 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 446469007407 active site 446469007408 dimerization interface [polypeptide binding]; other site 446469007409 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 446469007410 glutamate racemase; Provisional; Region: PRK00865 446469007411 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 446469007412 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 446469007413 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 446469007414 active site 446469007415 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 446469007416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469007417 ATP binding site [chemical binding]; other site 446469007418 putative Mg++ binding site [ion binding]; other site 446469007419 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 446469007420 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 446469007421 putative active site [active] 446469007422 catalytic triad [active] 446469007423 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446469007424 catalytic residues [active] 446469007425 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 446469007426 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 446469007427 SmpB-tmRNA interface; other site 446469007428 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446469007429 Peptidase family M23; Region: Peptidase_M23; pfam01551 446469007430 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 446469007431 FtsX-like permease family; Region: FtsX; pfam02687 446469007432 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 446469007433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469007434 Walker A/P-loop; other site 446469007435 ATP binding site [chemical binding]; other site 446469007436 Q-loop/lid; other site 446469007437 ABC transporter signature motif; other site 446469007438 Walker B; other site 446469007439 D-loop; other site 446469007440 H-loop/switch region; other site 446469007441 peptide chain release factor 2; Validated; Region: prfB; PRK00578 446469007442 This domain is found in peptide chain release factors; Region: PCRF; smart00937 446469007443 RF-1 domain; Region: RF-1; pfam00472 446469007444 Clp amino terminal domain; Region: Clp_N; pfam02861 446469007445 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 446469007446 hydrophobic ligand binding site; other site 446469007447 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 446469007448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469007449 non-specific DNA binding site [nucleotide binding]; other site 446469007450 salt bridge; other site 446469007451 sequence-specific DNA binding site [nucleotide binding]; other site 446469007452 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 446469007453 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446469007454 oligomer interface [polypeptide binding]; other site 446469007455 active site residues [active] 446469007456 Clp protease; Region: CLP_protease; pfam00574 446469007457 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446469007458 oligomer interface [polypeptide binding]; other site 446469007459 active site residues [active] 446469007460 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469007461 MarR family; Region: MarR_2; cl17246 446469007462 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 446469007463 EamA-like transporter family; Region: EamA; pfam00892 446469007464 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446469007465 FtsX-like permease family; Region: FtsX; pfam02687 446469007466 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446469007467 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446469007468 Walker A/P-loop; other site 446469007469 ATP binding site [chemical binding]; other site 446469007470 Q-loop/lid; other site 446469007471 ABC transporter signature motif; other site 446469007472 Walker B; other site 446469007473 D-loop; other site 446469007474 H-loop/switch region; other site 446469007475 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446469007476 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 446469007477 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469007478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469007479 active site 446469007480 phosphorylation site [posttranslational modification] 446469007481 intermolecular recognition site; other site 446469007482 dimerization interface [polypeptide binding]; other site 446469007483 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469007484 DNA binding site [nucleotide binding] 446469007485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469007486 dimerization interface [polypeptide binding]; other site 446469007487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469007488 dimer interface [polypeptide binding]; other site 446469007489 phosphorylation site [posttranslational modification] 446469007490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469007491 ATP binding site [chemical binding]; other site 446469007492 G-X-G motif; other site 446469007493 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 446469007494 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 446469007495 potential catalytic triad [active] 446469007496 conserved cys residue [active] 446469007497 Prostaglandin dehydrogenases; Region: PGDH; cd05288 446469007498 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 446469007499 NAD(P) binding site [chemical binding]; other site 446469007500 substrate binding site [chemical binding]; other site 446469007501 dimer interface [polypeptide binding]; other site 446469007502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469007503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469007504 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 446469007505 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 446469007506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469007507 putative substrate translocation pore; other site 446469007508 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 446469007509 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 446469007510 cyclase homology domain; Region: CHD; cd07302 446469007511 nucleotidyl binding site; other site 446469007512 metal binding site [ion binding]; metal-binding site 446469007513 dimer interface [polypeptide binding]; other site 446469007514 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 446469007515 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 446469007516 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 446469007517 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 446469007518 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 446469007519 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 446469007520 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 446469007521 putative active site [active] 446469007522 redox center [active] 446469007523 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446469007524 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 446469007525 active site 446469007526 dimer interface [polypeptide binding]; other site 446469007527 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 446469007528 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446469007529 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 446469007530 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 446469007531 NUDIX domain; Region: NUDIX; pfam00293 446469007532 nudix motif; other site 446469007533 Iron permease FTR1 family; Region: FTR1; pfam03239 446469007534 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 446469007535 Imelysin; Region: Peptidase_M75; pfam09375 446469007536 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 446469007537 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446469007538 putative catalytic site [active] 446469007539 putative metal binding site [ion binding]; other site 446469007540 putative catalytic site [active] 446469007541 putative phosphate binding site [ion binding]; other site 446469007542 putative phosphate binding site [ion binding]; other site 446469007543 putative metal binding site [ion binding]; other site 446469007544 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 446469007545 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446469007546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446469007547 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446469007548 purine nucleoside phosphorylase; Provisional; Region: PRK08202 446469007549 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 446469007550 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 446469007551 active site 446469007552 substrate binding site [chemical binding]; other site 446469007553 metal binding site [ion binding]; metal-binding site 446469007554 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 446469007555 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446469007556 Histidine kinase; Region: HisKA_3; pfam07730 446469007557 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469007558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469007559 active site 446469007560 phosphorylation site [posttranslational modification] 446469007561 intermolecular recognition site; other site 446469007562 dimerization interface [polypeptide binding]; other site 446469007563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469007564 DNA binding residues [nucleotide binding] 446469007565 dimerization interface [polypeptide binding]; other site 446469007566 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446469007567 RibD C-terminal domain; Region: RibD_C; cl17279 446469007568 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446469007569 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446469007570 FAD binding pocket [chemical binding]; other site 446469007571 FAD binding motif [chemical binding]; other site 446469007572 phosphate binding motif [ion binding]; other site 446469007573 NAD binding pocket [chemical binding]; other site 446469007574 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 446469007575 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 446469007576 metal binding site [ion binding]; metal-binding site 446469007577 active site 446469007578 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 446469007579 intersubunit interface [polypeptide binding]; other site 446469007580 active site 446469007581 catalytic residue [active] 446469007582 adenosine deaminase; Provisional; Region: PRK09358 446469007583 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446469007584 active site 446469007585 Domain of unknown function (DUF202); Region: DUF202; cl09954 446469007586 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 446469007587 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446469007588 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446469007589 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 446469007590 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 446469007591 active site 446469007592 catalytic motif [active] 446469007593 Zn binding site [ion binding]; other site 446469007594 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446469007595 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446469007596 TM-ABC transporter signature motif; other site 446469007597 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446469007598 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446469007599 TM-ABC transporter signature motif; other site 446469007600 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 446469007601 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446469007602 Walker A/P-loop; other site 446469007603 ATP binding site [chemical binding]; other site 446469007604 Q-loop/lid; other site 446469007605 ABC transporter signature motif; other site 446469007606 Walker B; other site 446469007607 D-loop; other site 446469007608 H-loop/switch region; other site 446469007609 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446469007610 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 446469007611 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 446469007612 ligand binding site [chemical binding]; other site 446469007613 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446469007614 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 446469007615 metal binding site [ion binding]; metal-binding site 446469007616 putative dimer interface [polypeptide binding]; other site 446469007617 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 446469007618 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 446469007619 Substrate binding site; other site 446469007620 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 446469007621 putative Iron-sulfur protein interface [polypeptide binding]; other site 446469007622 putative proximal heme binding site [chemical binding]; other site 446469007623 putative SdhD-like interface [polypeptide binding]; other site 446469007624 putative distal heme binding site [chemical binding]; other site 446469007625 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 446469007626 putative Iron-sulfur protein interface [polypeptide binding]; other site 446469007627 putative proximal heme binding site [chemical binding]; other site 446469007628 putative SdhC-like subunit interface [polypeptide binding]; other site 446469007629 putative distal heme binding site [chemical binding]; other site 446469007630 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 446469007631 L-aspartate oxidase; Provisional; Region: PRK06175 446469007632 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446469007633 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 446469007634 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446469007635 catalytic loop [active] 446469007636 iron binding site [ion binding]; other site 446469007637 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 446469007638 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 446469007639 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 446469007640 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 446469007641 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 446469007642 active site 446469007643 HIGH motif; other site 446469007644 dimer interface [polypeptide binding]; other site 446469007645 KMSKS motif; other site 446469007646 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 446469007647 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 446469007648 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446469007649 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 446469007650 Putative zinc-finger; Region: zf-HC2; pfam13490 446469007651 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446469007652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469007653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469007654 DNA binding residues [nucleotide binding] 446469007655 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 446469007656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446469007657 S-adenosylmethionine binding site [chemical binding]; other site 446469007658 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 446469007659 multifunctional aminopeptidase A; Provisional; Region: PRK00913 446469007660 interface (dimer of trimers) [polypeptide binding]; other site 446469007661 Substrate-binding/catalytic site; other site 446469007662 Zn-binding sites [ion binding]; other site 446469007663 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 446469007664 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 446469007665 dihydropteroate synthase; Region: DHPS; TIGR01496 446469007666 substrate binding pocket [chemical binding]; other site 446469007667 dimer interface [polypeptide binding]; other site 446469007668 inhibitor binding site; inhibition site 446469007669 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 446469007670 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 446469007671 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 446469007672 metal binding site [ion binding]; metal-binding site 446469007673 putative dimer interface [polypeptide binding]; other site 446469007674 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 446469007675 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 446469007676 putative trimer interface [polypeptide binding]; other site 446469007677 putative CoA binding site [chemical binding]; other site 446469007678 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 446469007679 dimer interface [polypeptide binding]; other site 446469007680 Citrate synthase; Region: Citrate_synt; pfam00285 446469007681 active site 446469007682 citrylCoA binding site [chemical binding]; other site 446469007683 NADH binding [chemical binding]; other site 446469007684 cationic pore residues; other site 446469007685 oxalacetate/citrate binding site [chemical binding]; other site 446469007686 coenzyme A binding site [chemical binding]; other site 446469007687 catalytic triad [active] 446469007688 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 446469007689 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446469007690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469007691 homodimer interface [polypeptide binding]; other site 446469007692 catalytic residue [active] 446469007693 Ferredoxin [Energy production and conversion]; Region: COG1146 446469007694 4Fe-4S binding domain; Region: Fer4; pfam00037 446469007695 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 446469007696 prephenate dehydrogenase; Validated; Region: PRK08507 446469007697 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 446469007698 Prephenate dehydratase; Region: PDT; pfam00800 446469007699 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 446469007700 putative L-Phe binding site [chemical binding]; other site 446469007701 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446469007702 VanW like protein; Region: VanW; pfam04294 446469007703 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446469007704 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 446469007705 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 446469007706 G1 box; other site 446469007707 putative GEF interaction site [polypeptide binding]; other site 446469007708 GTP/Mg2+ binding site [chemical binding]; other site 446469007709 Switch I region; other site 446469007710 G2 box; other site 446469007711 G3 box; other site 446469007712 Switch II region; other site 446469007713 G4 box; other site 446469007714 G5 box; other site 446469007715 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 446469007716 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 446469007717 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446469007718 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446469007719 Walker A/P-loop; other site 446469007720 ATP binding site [chemical binding]; other site 446469007721 Q-loop/lid; other site 446469007722 ABC transporter signature motif; other site 446469007723 Walker B; other site 446469007724 D-loop; other site 446469007725 H-loop/switch region; other site 446469007726 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446469007727 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446469007728 Walker A/P-loop; other site 446469007729 ATP binding site [chemical binding]; other site 446469007730 Q-loop/lid; other site 446469007731 ABC transporter signature motif; other site 446469007732 Walker B; other site 446469007733 D-loop; other site 446469007734 H-loop/switch region; other site 446469007735 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446469007736 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469007737 Walker A/P-loop; other site 446469007738 ATP binding site [chemical binding]; other site 446469007739 Q-loop/lid; other site 446469007740 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446469007741 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469007742 ABC transporter signature motif; other site 446469007743 Walker B; other site 446469007744 D-loop; other site 446469007745 H-loop/switch region; other site 446469007746 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446469007747 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469007748 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446469007749 Walker A/P-loop; other site 446469007750 ATP binding site [chemical binding]; other site 446469007751 Q-loop/lid; other site 446469007752 ABC transporter signature motif; other site 446469007753 Walker B; other site 446469007754 D-loop; other site 446469007755 H-loop/switch region; other site 446469007756 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469007757 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446469007758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469007759 dimer interface [polypeptide binding]; other site 446469007760 conserved gate region; other site 446469007761 putative PBP binding loops; other site 446469007762 ABC-ATPase subunit interface; other site 446469007763 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446469007764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469007765 dimer interface [polypeptide binding]; other site 446469007766 conserved gate region; other site 446469007767 ABC-ATPase subunit interface; other site 446469007768 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446469007769 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446469007770 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 446469007771 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446469007772 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469007773 Walker A/P-loop; other site 446469007774 ATP binding site [chemical binding]; other site 446469007775 Q-loop/lid; other site 446469007776 ABC transporter signature motif; other site 446469007777 Walker B; other site 446469007778 D-loop; other site 446469007779 H-loop/switch region; other site 446469007780 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446469007781 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469007782 Walker A/P-loop; other site 446469007783 ATP binding site [chemical binding]; other site 446469007784 Q-loop/lid; other site 446469007785 ABC transporter signature motif; other site 446469007786 Walker B; other site 446469007787 D-loop; other site 446469007788 H-loop/switch region; other site 446469007789 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469007790 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446469007791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469007792 dimer interface [polypeptide binding]; other site 446469007793 conserved gate region; other site 446469007794 putative PBP binding loops; other site 446469007795 ABC-ATPase subunit interface; other site 446469007796 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446469007797 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446469007798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469007799 putative PBP binding loops; other site 446469007800 dimer interface [polypeptide binding]; other site 446469007801 ABC-ATPase subunit interface; other site 446469007802 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 446469007803 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446469007804 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446469007805 synthetase active site [active] 446469007806 NTP binding site [chemical binding]; other site 446469007807 metal binding site [ion binding]; metal-binding site 446469007808 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 446469007809 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 446469007810 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446469007811 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 446469007812 hydroxyglutarate oxidase; Provisional; Region: PRK11728 446469007813 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 446469007814 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 446469007815 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 446469007816 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446469007817 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 446469007818 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 446469007819 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 446469007820 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446469007821 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 446469007822 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 446469007823 active site 446469007824 NTP binding site [chemical binding]; other site 446469007825 metal binding triad [ion binding]; metal-binding site 446469007826 antibiotic binding site [chemical binding]; other site 446469007827 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446469007828 catalytic core [active] 446469007829 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 446469007830 conserved hypothetical protein; Region: TIGR03843 446469007831 Restriction endonuclease; Region: Mrr_cat; pfam04471 446469007832 GTP-binding protein YchF; Reviewed; Region: PRK09601 446469007833 YchF GTPase; Region: YchF; cd01900 446469007834 G1 box; other site 446469007835 GTP/Mg2+ binding site [chemical binding]; other site 446469007836 Switch I region; other site 446469007837 G2 box; other site 446469007838 Switch II region; other site 446469007839 G3 box; other site 446469007840 G4 box; other site 446469007841 G5 box; other site 446469007842 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 446469007843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469007844 RmuC family; Region: RmuC; pfam02646 446469007845 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 446469007846 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 446469007847 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 446469007848 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 446469007849 generic binding surface II; other site 446469007850 generic binding surface I; other site 446469007851 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 446469007852 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 446469007853 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446469007854 putative substrate binding site [chemical binding]; other site 446469007855 putative ATP binding site [chemical binding]; other site 446469007856 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 446469007857 active site clefts [active] 446469007858 zinc binding site [ion binding]; other site 446469007859 dimer interface [polypeptide binding]; other site 446469007860 fumarate hydratase; Reviewed; Region: fumC; PRK00485 446469007861 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 446469007862 active sites [active] 446469007863 tetramer interface [polypeptide binding]; other site 446469007864 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 446469007865 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 446469007866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 446469007867 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469007868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469007869 DNA binding residues [nucleotide binding] 446469007870 dimerization interface [polypeptide binding]; other site 446469007871 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 446469007872 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 446469007873 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 446469007874 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 446469007875 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 446469007876 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 446469007877 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 446469007878 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 446469007879 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 446469007880 phage tail protein domain; Region: tail_TIGR02242 446469007881 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446469007882 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 446469007883 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446469007884 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446469007885 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446469007886 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446469007887 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446469007888 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446469007889 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446469007890 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446469007891 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446469007892 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 446469007893 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 446469007894 Septum formation; Region: Septum_form; pfam13845 446469007895 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469007896 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 446469007897 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 446469007898 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446469007899 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446469007900 intersubunit interface [polypeptide binding]; other site 446469007901 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446469007902 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446469007903 FAD binding pocket [chemical binding]; other site 446469007904 FAD binding motif [chemical binding]; other site 446469007905 phosphate binding motif [ion binding]; other site 446469007906 NAD binding pocket [chemical binding]; other site 446469007907 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 446469007908 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469007909 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446469007910 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 446469007911 putative NAD(P) binding site [chemical binding]; other site 446469007912 haloalkane dehalogenase; Provisional; Region: PRK03592 446469007913 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446469007914 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 446469007915 CGNR zinc finger; Region: zf-CGNR; pfam11706 446469007916 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 446469007917 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446469007918 putative catalytic site [active] 446469007919 putative metal binding site [ion binding]; other site 446469007920 putative phosphate binding site [ion binding]; other site 446469007921 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 446469007922 dimerization interface [polypeptide binding]; other site 446469007923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469007924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469007925 dimer interface [polypeptide binding]; other site 446469007926 phosphorylation site [posttranslational modification] 446469007927 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469007928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469007929 ATP binding site [chemical binding]; other site 446469007930 Mg2+ binding site [ion binding]; other site 446469007931 G-X-G motif; other site 446469007932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469007933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469007934 active site 446469007935 phosphorylation site [posttranslational modification] 446469007936 intermolecular recognition site; other site 446469007937 dimerization interface [polypeptide binding]; other site 446469007938 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469007939 DNA binding site [nucleotide binding] 446469007940 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 446469007941 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 446469007942 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 446469007943 putative active site [active] 446469007944 PhoH-like protein; Region: PhoH; pfam02562 446469007945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469007946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469007947 putative substrate translocation pore; other site 446469007948 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 446469007949 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 446469007950 Histidine kinase; Region: HisKA_3; pfam07730 446469007951 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446469007952 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469007953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469007954 active site 446469007955 phosphorylation site [posttranslational modification] 446469007956 intermolecular recognition site; other site 446469007957 dimerization interface [polypeptide binding]; other site 446469007958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469007959 DNA binding residues [nucleotide binding] 446469007960 dimerization interface [polypeptide binding]; other site 446469007961 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 446469007962 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446469007963 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 446469007964 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 446469007965 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 446469007966 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446469007967 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 446469007968 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 446469007969 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 446469007970 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 446469007971 Predicted membrane protein [Function unknown]; Region: COG4425 446469007972 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 446469007973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469007974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469007975 intermolecular recognition site; other site 446469007976 active site 446469007977 dimerization interface [polypeptide binding]; other site 446469007978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469007979 DNA binding site [nucleotide binding] 446469007980 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 446469007981 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 446469007982 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 446469007983 Ligand Binding Site [chemical binding]; other site 446469007984 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 446469007985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469007986 dimer interface [polypeptide binding]; other site 446469007987 phosphorylation site [posttranslational modification] 446469007988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469007989 ATP binding site [chemical binding]; other site 446469007990 G-X-G motif; other site 446469007991 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 446469007992 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 446469007993 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446469007994 Soluble P-type ATPase [General function prediction only]; Region: COG4087 446469007995 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 446469007996 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 446469007997 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 446469007998 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 446469007999 putative active site [active] 446469008000 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 446469008001 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469008002 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469008003 DNA binding residues [nucleotide binding] 446469008004 Asp23 family; Region: Asp23; pfam03780 446469008005 Asp23 family; Region: Asp23; pfam03780 446469008006 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446469008007 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 446469008008 substrate binding site [chemical binding]; other site 446469008009 ATP binding site [chemical binding]; other site 446469008010 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 446469008011 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 446469008012 active site 446469008013 intersubunit interface [polypeptide binding]; other site 446469008014 catalytic residue [active] 446469008015 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446469008016 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446469008017 Bacterial transcriptional regulator; Region: IclR; pfam01614 446469008018 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446469008019 Ligand Binding Site [chemical binding]; other site 446469008020 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446469008021 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446469008022 calcium binding site 2 [ion binding]; other site 446469008023 active site 446469008024 catalytic triad [active] 446469008025 calcium binding site 1 [ion binding]; other site 446469008026 Fibronectin type 3 domain; Region: FN3; smart00060 446469008027 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446469008028 Interdomain contacts; other site 446469008029 Cytokine receptor motif; other site 446469008030 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446469008031 Interdomain contacts; other site 446469008032 Cytokine receptor motif; other site 446469008033 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 446469008034 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446469008035 DinB superfamily; Region: DinB_2; pfam12867 446469008036 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 446469008037 NmrA-like family; Region: NmrA; pfam05368 446469008038 NADP binding site [chemical binding]; other site 446469008039 Predicted transcriptional regulators [Transcription]; Region: COG1733 446469008040 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446469008041 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446469008042 substrate binding pocket [chemical binding]; other site 446469008043 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 446469008044 putative Zn2+ binding site [ion binding]; other site 446469008045 putative DNA binding site [nucleotide binding]; other site 446469008046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469008047 putative substrate translocation pore; other site 446469008048 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 446469008049 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 446469008050 putative active site [active] 446469008051 putative ligand binding site [chemical binding]; other site 446469008052 putative NAD(P) binding site [chemical binding]; other site 446469008053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469008054 NAD(P) binding site [chemical binding]; other site 446469008055 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446469008056 active site 446469008057 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469008058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469008059 dimer interface [polypeptide binding]; other site 446469008060 conserved gate region; other site 446469008061 putative PBP binding loops; other site 446469008062 ABC-ATPase subunit interface; other site 446469008063 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446469008064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469008065 ABC-ATPase subunit interface; other site 446469008066 putative PBP binding loops; other site 446469008067 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469008068 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446469008069 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 446469008070 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 446469008071 active site 446469008072 catalytic site [active] 446469008073 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446469008074 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469008075 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469008076 DNA binding site [nucleotide binding] 446469008077 domain linker motif; other site 446469008078 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 446469008079 putative dimerization interface [polypeptide binding]; other site 446469008080 putative ligand binding site [chemical binding]; other site 446469008081 Putative sensor; Region: Sensor; pfam13796 446469008082 Protein of unknown function (DUF429); Region: DUF429; cl12046 446469008083 MMPL family; Region: MMPL; pfam03176 446469008084 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 446469008085 dimerization interface [polypeptide binding]; other site 446469008086 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446469008087 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469008088 dimer interface [polypeptide binding]; other site 446469008089 putative CheW interface [polypeptide binding]; other site 446469008090 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446469008091 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446469008092 active site 446469008093 catalytic tetrad [active] 446469008094 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446469008095 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446469008096 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 446469008097 active site 446469008098 catalytic residues [active] 446469008099 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 446469008100 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 446469008101 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 446469008102 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 446469008103 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 446469008104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469008105 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 446469008106 Protein of unknown function DUF45; Region: DUF45; cl00636 446469008107 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 446469008108 ATP binding site [chemical binding]; other site 446469008109 Transcription factor WhiB; Region: Whib; pfam02467 446469008110 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 446469008111 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446469008112 Part of AAA domain; Region: AAA_19; pfam13245 446469008113 Family description; Region: UvrD_C_2; pfam13538 446469008114 HRDC domain; Region: HRDC; pfam00570 446469008115 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 446469008116 catalytic residues [active] 446469008117 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 446469008118 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 446469008119 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 446469008120 putative NADH binding site [chemical binding]; other site 446469008121 putative active site [active] 446469008122 nudix motif; other site 446469008123 putative metal binding site [ion binding]; other site 446469008124 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446469008125 active site 446469008126 ATP binding site [chemical binding]; other site 446469008127 Phosphotransferase enzyme family; Region: APH; pfam01636 446469008128 substrate binding site [chemical binding]; other site 446469008129 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 446469008130 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 446469008131 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 446469008132 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 446469008133 active site 446469008134 non-prolyl cis peptide bond; other site 446469008135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469008136 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446469008137 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446469008138 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446469008139 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446469008140 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 446469008141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469008142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469008143 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 446469008144 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469008145 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469008146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469008147 dimer interface [polypeptide binding]; other site 446469008148 conserved gate region; other site 446469008149 putative PBP binding loops; other site 446469008150 ABC-ATPase subunit interface; other site 446469008151 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469008152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469008153 dimer interface [polypeptide binding]; other site 446469008154 conserved gate region; other site 446469008155 putative PBP binding loops; other site 446469008156 ABC-ATPase subunit interface; other site 446469008157 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 446469008158 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469008159 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446469008160 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 446469008161 helicase 45; Provisional; Region: PTZ00424 446469008162 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446469008163 ATP binding site [chemical binding]; other site 446469008164 Mg++ binding site [ion binding]; other site 446469008165 motif III; other site 446469008166 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469008167 nucleotide binding region [chemical binding]; other site 446469008168 ATP-binding site [chemical binding]; other site 446469008169 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446469008170 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446469008171 DNA binding residues [nucleotide binding] 446469008172 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 446469008173 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 446469008174 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 446469008175 active site 446469008176 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 446469008177 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446469008178 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 446469008179 proline aminopeptidase P II; Provisional; Region: PRK10879 446469008180 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 446469008181 active site 446469008182 MgtE intracellular N domain; Region: MgtE_N; smart00924 446469008183 FOG: CBS domain [General function prediction only]; Region: COG0517 446469008184 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 446469008185 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 446469008186 Domain of unknown function DUF59; Region: DUF59; cl00941 446469008187 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 446469008188 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 446469008189 Walker A motif; other site 446469008190 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446469008191 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446469008192 Walker A/P-loop; other site 446469008193 ATP binding site [chemical binding]; other site 446469008194 Q-loop/lid; other site 446469008195 ABC transporter signature motif; other site 446469008196 Walker B; other site 446469008197 D-loop; other site 446469008198 H-loop/switch region; other site 446469008199 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446469008200 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446469008201 FtsX-like permease family; Region: FtsX; pfam02687 446469008202 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 446469008203 putative active site [active] 446469008204 putative catalytic site [active] 446469008205 putative DNA binding site [nucleotide binding]; other site 446469008206 putative phosphate binding site [ion binding]; other site 446469008207 metal binding site A [ion binding]; metal-binding site 446469008208 putative AP binding site [nucleotide binding]; other site 446469008209 putative metal binding site B [ion binding]; other site 446469008210 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469008211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469008212 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 446469008213 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446469008214 putative NAD(P) binding site [chemical binding]; other site 446469008215 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 446469008216 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 446469008217 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 446469008218 homodimer interface [polypeptide binding]; other site 446469008219 NADP binding site [chemical binding]; other site 446469008220 substrate binding site [chemical binding]; other site 446469008221 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 446469008222 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 446469008223 dimer interface [polypeptide binding]; other site 446469008224 active site 446469008225 glycine-pyridoxal phosphate binding site [chemical binding]; other site 446469008226 folate binding site [chemical binding]; other site 446469008227 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 446469008228 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 446469008229 putative ligand binding site [chemical binding]; other site 446469008230 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 446469008231 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446469008232 Walker A/P-loop; other site 446469008233 ATP binding site [chemical binding]; other site 446469008234 Q-loop/lid; other site 446469008235 ABC transporter signature motif; other site 446469008236 Walker B; other site 446469008237 D-loop; other site 446469008238 H-loop/switch region; other site 446469008239 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446469008240 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446469008241 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446469008242 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446469008243 TM-ABC transporter signature motif; other site 446469008244 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469008245 putative DNA binding site [nucleotide binding]; other site 446469008246 putative Zn2+ binding site [ion binding]; other site 446469008247 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469008248 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446469008249 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446469008250 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446469008251 Walker A/P-loop; other site 446469008252 ATP binding site [chemical binding]; other site 446469008253 Q-loop/lid; other site 446469008254 ABC transporter signature motif; other site 446469008255 Walker B; other site 446469008256 D-loop; other site 446469008257 H-loop/switch region; other site 446469008258 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446469008259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469008260 Coenzyme A binding pocket [chemical binding]; other site 446469008261 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446469008262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446469008263 DNA-binding site [nucleotide binding]; DNA binding site 446469008264 FCD domain; Region: FCD; pfam07729 446469008265 cytosine deaminase; Provisional; Region: PRK05985 446469008266 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 446469008267 active site 446469008268 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446469008269 RibD C-terminal domain; Region: RibD_C; cl17279 446469008270 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 446469008271 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 446469008272 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 446469008273 putative active site [active] 446469008274 putative substrate binding site [chemical binding]; other site 446469008275 putative cosubstrate binding site; other site 446469008276 catalytic site [active] 446469008277 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 446469008278 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 446469008279 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446469008280 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 446469008281 active site 446469008282 catalytic site [active] 446469008283 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 446469008284 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 446469008285 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 446469008286 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 446469008287 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 446469008288 Ca binding site [ion binding]; other site 446469008289 active site 446469008290 catalytic site [active] 446469008291 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 446469008292 malate dehydrogenase; Provisional; Region: PRK05442 446469008293 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 446469008294 NAD(P) binding site [chemical binding]; other site 446469008295 dimer interface [polypeptide binding]; other site 446469008296 malate binding site [chemical binding]; other site 446469008297 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 446469008298 amphipathic channel; other site 446469008299 Asn-Pro-Ala signature motifs; other site 446469008300 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446469008301 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 446469008302 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 446469008303 purine monophosphate binding site [chemical binding]; other site 446469008304 dimer interface [polypeptide binding]; other site 446469008305 putative catalytic residues [active] 446469008306 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 446469008307 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 446469008308 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 446469008309 active site 446469008310 cosubstrate binding site; other site 446469008311 substrate binding site [chemical binding]; other site 446469008312 catalytic site [active] 446469008313 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 446469008314 CoA binding domain; Region: CoA_binding; smart00881 446469008315 CoA-ligase; Region: Ligase_CoA; pfam00549 446469008316 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 446469008317 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 446469008318 CoA-ligase; Region: Ligase_CoA; pfam00549 446469008319 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446469008320 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446469008321 Walker A/P-loop; other site 446469008322 ATP binding site [chemical binding]; other site 446469008323 Q-loop/lid; other site 446469008324 ABC transporter signature motif; other site 446469008325 Walker B; other site 446469008326 D-loop; other site 446469008327 H-loop/switch region; other site 446469008328 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 446469008329 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 446469008330 oligomer interface [polypeptide binding]; other site 446469008331 metal binding site [ion binding]; metal-binding site 446469008332 metal binding site [ion binding]; metal-binding site 446469008333 putative Cl binding site [ion binding]; other site 446469008334 basic sphincter; other site 446469008335 hydrophobic gate; other site 446469008336 periplasmic entrance; other site 446469008337 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446469008338 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 446469008339 Part of AAA domain; Region: AAA_19; pfam13245 446469008340 Family description; Region: UvrD_C_2; pfam13538 446469008341 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 446469008342 putative dimer interface [polypeptide binding]; other site 446469008343 catalytic triad [active] 446469008344 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446469008345 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446469008346 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446469008347 AAA domain; Region: AAA_18; pfam13238 446469008348 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446469008349 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446469008350 active site residue [active] 446469008351 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446469008352 active site residue [active] 446469008353 hypothetical protein; Provisional; Region: PRK09256 446469008354 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 446469008355 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 446469008356 putative active site [active] 446469008357 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 446469008358 putative active site [active] 446469008359 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469008360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469008361 active site 446469008362 phosphorylation site [posttranslational modification] 446469008363 intermolecular recognition site; other site 446469008364 dimerization interface [polypeptide binding]; other site 446469008365 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469008366 DNA binding residues [nucleotide binding] 446469008367 dimerization interface [polypeptide binding]; other site 446469008368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446469008369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469008370 ATP binding site [chemical binding]; other site 446469008371 Mg2+ binding site [ion binding]; other site 446469008372 G-X-G motif; other site 446469008373 PspC domain; Region: PspC; cl00864 446469008374 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 446469008375 GMP synthase; Reviewed; Region: guaA; PRK00074 446469008376 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 446469008377 AMP/PPi binding site [chemical binding]; other site 446469008378 candidate oxyanion hole; other site 446469008379 catalytic triad [active] 446469008380 potential glutamine specificity residues [chemical binding]; other site 446469008381 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 446469008382 ATP Binding subdomain [chemical binding]; other site 446469008383 Ligand Binding sites [chemical binding]; other site 446469008384 Dimerization subdomain; other site 446469008385 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 446469008386 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446469008387 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 446469008388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469008389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469008390 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 446469008391 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446469008392 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469008393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469008394 Walker A/P-loop; other site 446469008395 ATP binding site [chemical binding]; other site 446469008396 Q-loop/lid; other site 446469008397 ABC transporter signature motif; other site 446469008398 Walker B; other site 446469008399 D-loop; other site 446469008400 H-loop/switch region; other site 446469008401 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469008402 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446469008403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469008404 Walker A/P-loop; other site 446469008405 ATP binding site [chemical binding]; other site 446469008406 Q-loop/lid; other site 446469008407 ABC transporter signature motif; other site 446469008408 Walker B; other site 446469008409 D-loop; other site 446469008410 H-loop/switch region; other site 446469008411 YceI-like domain; Region: YceI; pfam04264 446469008412 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 446469008413 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446469008414 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 446469008415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469008416 Walker A/P-loop; other site 446469008417 ATP binding site [chemical binding]; other site 446469008418 Q-loop/lid; other site 446469008419 ABC transporter signature motif; other site 446469008420 Walker B; other site 446469008421 D-loop; other site 446469008422 H-loop/switch region; other site 446469008423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469008424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469008425 putative phosphoketolase; Provisional; Region: PRK05261 446469008426 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 446469008427 TPP-binding site; other site 446469008428 Src Homology 3 domain superfamily; Region: SH3; cl17036 446469008429 peptide ligand binding site [polypeptide binding]; other site 446469008430 XFP C-terminal domain; Region: XFP_C; pfam09363 446469008431 phosphate acetyltransferase; Reviewed; Region: PRK05632 446469008432 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446469008433 DRTGG domain; Region: DRTGG; pfam07085 446469008434 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 446469008435 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 446469008436 propionate/acetate kinase; Provisional; Region: PRK12379 446469008437 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 446469008438 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446469008439 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446469008440 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 446469008441 Right handed beta helix region; Region: Beta_helix; pfam13229 446469008442 Right handed beta helix region; Region: Beta_helix; pfam13229 446469008443 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446469008444 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446469008445 active site 446469008446 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446469008447 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446469008448 NAD(P) binding site [chemical binding]; other site 446469008449 catalytic residues [active] 446469008450 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 446469008451 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 446469008452 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446469008453 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 446469008454 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 446469008455 dimerization domain swap beta strand [polypeptide binding]; other site 446469008456 regulatory protein interface [polypeptide binding]; other site 446469008457 active site 446469008458 regulatory phosphorylation site [posttranslational modification]; other site 446469008459 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 446469008460 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 446469008461 active site 446469008462 P-loop; other site 446469008463 phosphorylation site [posttranslational modification] 446469008464 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 446469008465 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 446469008466 active site 446469008467 phosphorylation site [posttranslational modification] 446469008468 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 446469008469 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 446469008470 putative substrate binding site [chemical binding]; other site 446469008471 putative ATP binding site [chemical binding]; other site 446469008472 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446469008473 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446469008474 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446469008475 putative acetyltransferase; Provisional; Region: PRK03624 446469008476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469008477 Coenzyme A binding pocket [chemical binding]; other site 446469008478 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 446469008479 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 446469008480 active site 446469008481 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 446469008482 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446469008483 active site 446469008484 catalytic site [active] 446469008485 substrate binding site [chemical binding]; other site 446469008486 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 446469008487 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 446469008488 active site 446469008489 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 446469008490 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446469008491 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 446469008492 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 446469008493 active site 446469008494 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446469008495 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446469008496 DNA binding residues [nucleotide binding] 446469008497 Transcription factor WhiB; Region: Whib; pfam02467 446469008498 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 446469008499 oligomerisation interface [polypeptide binding]; other site 446469008500 mobile loop; other site 446469008501 roof hairpin; other site 446469008502 integrase; Provisional; Region: int; PHA02601 446469008503 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 446469008504 active site 446469008505 catalytic residues [active] 446469008506 DNA binding site [nucleotide binding] 446469008507 Int/Topo IB signature motif; other site 446469008508 Helix-turn-helix domain; Region: HTH_17; pfam12728 446469008509 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 446469008510 catalytic residues [active] 446469008511 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 446469008512 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446469008513 HSP70 interaction site [polypeptide binding]; other site 446469008514 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446469008515 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 446469008516 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 446469008517 catalytic residues [active] 446469008518 catalytic nucleophile [active] 446469008519 Presynaptic Site I dimer interface [polypeptide binding]; other site 446469008520 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 446469008521 Synaptic Flat tetramer interface [polypeptide binding]; other site 446469008522 Synaptic Site I dimer interface [polypeptide binding]; other site 446469008523 DNA binding site [nucleotide binding] 446469008524 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 446469008525 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 446469008526 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 446469008527 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 446469008528 putative active site [active] 446469008529 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 446469008530 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 446469008531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469008532 ABC-ATPase subunit interface; other site 446469008533 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 446469008534 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 446469008535 Walker A/P-loop; other site 446469008536 ATP binding site [chemical binding]; other site 446469008537 Q-loop/lid; other site 446469008538 ABC transporter signature motif; other site 446469008539 Walker B; other site 446469008540 D-loop; other site 446469008541 H-loop/switch region; other site 446469008542 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 446469008543 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 446469008544 carboxylate-amine ligase; Provisional; Region: PRK13517 446469008545 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 446469008546 Predicted transcriptional regulators [Transcription]; Region: COG1695 446469008547 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446469008548 UGMP family protein; Validated; Region: PRK09604 446469008549 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 446469008550 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446469008551 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446469008552 active site residue [active] 446469008553 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446469008554 active site residue [active] 446469008555 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 446469008556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469008557 Coenzyme A binding pocket [chemical binding]; other site 446469008558 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 446469008559 Glycoprotease family; Region: Peptidase_M22; pfam00814 446469008560 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 446469008561 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 446469008562 alanine racemase; Reviewed; Region: alr; PRK00053 446469008563 active site 446469008564 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446469008565 dimer interface [polypeptide binding]; other site 446469008566 substrate binding site [chemical binding]; other site 446469008567 catalytic residues [active] 446469008568 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 446469008569 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446469008570 active site 446469008571 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 446469008572 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 446469008573 putative substrate binding site [chemical binding]; other site 446469008574 putative ATP binding site [chemical binding]; other site 446469008575 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446469008576 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 446469008577 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 446469008578 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 446469008579 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 446469008580 glutaminase active site [active] 446469008581 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446469008582 dimer interface [polypeptide binding]; other site 446469008583 active site 446469008584 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 446469008585 dimer interface [polypeptide binding]; other site 446469008586 active site 446469008587 pantothenate kinase; Provisional; Region: PRK05439 446469008588 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 446469008589 ATP-binding site [chemical binding]; other site 446469008590 CoA-binding site [chemical binding]; other site 446469008591 Mg2+-binding site [ion binding]; other site 446469008592 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446469008593 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446469008594 active site 446469008595 catalytic residues [active] 446469008596 metal binding site [ion binding]; metal-binding site 446469008597 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 446469008598 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 446469008599 active site 446469008600 substrate binding site [chemical binding]; other site 446469008601 metal binding site [ion binding]; metal-binding site 446469008602 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 446469008603 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 446469008604 23S rRNA interface [nucleotide binding]; other site 446469008605 L3 interface [polypeptide binding]; other site 446469008606 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 446469008607 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 446469008608 active site residue [active] 446469008609 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446469008610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469008611 Walker A/P-loop; other site 446469008612 ATP binding site [chemical binding]; other site 446469008613 Q-loop/lid; other site 446469008614 ABC transporter signature motif; other site 446469008615 Walker B; other site 446469008616 D-loop; other site 446469008617 H-loop/switch region; other site 446469008618 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469008619 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 446469008620 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 446469008621 dimerization interface 3.5A [polypeptide binding]; other site 446469008622 active site 446469008623 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469008624 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446469008625 nucleotide binding site [chemical binding]; other site 446469008626 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 446469008627 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446469008628 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 446469008629 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 446469008630 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 446469008631 alphaNTD - beta interaction site [polypeptide binding]; other site 446469008632 alphaNTD homodimer interface [polypeptide binding]; other site 446469008633 alphaNTD - beta' interaction site [polypeptide binding]; other site 446469008634 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 446469008635 30S ribosomal protein S11; Validated; Region: PRK05309 446469008636 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 446469008637 30S ribosomal protein S13; Region: bact_S13; TIGR03631 446469008638 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 446469008639 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 446469008640 rRNA binding site [nucleotide binding]; other site 446469008641 predicted 30S ribosome binding site; other site 446469008642 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469008643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469008644 DNA binding residues [nucleotide binding] 446469008645 dimerization interface [polypeptide binding]; other site 446469008646 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446469008647 active site 446469008648 adenylate kinase; Reviewed; Region: adk; PRK00279 446469008649 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 446469008650 AMP-binding site [chemical binding]; other site 446469008651 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 446469008652 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 446469008653 SecY translocase; Region: SecY; pfam00344 446469008654 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 446469008655 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 446469008656 23S rRNA binding site [nucleotide binding]; other site 446469008657 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 446469008658 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 446469008659 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 446469008660 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 446469008661 5S rRNA interface [nucleotide binding]; other site 446469008662 L27 interface [polypeptide binding]; other site 446469008663 23S rRNA interface [nucleotide binding]; other site 446469008664 L5 interface [polypeptide binding]; other site 446469008665 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 446469008666 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446469008667 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446469008668 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 446469008669 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 446469008670 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 446469008671 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 446469008672 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 446469008673 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 446469008674 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 446469008675 RNA binding site [nucleotide binding]; other site 446469008676 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 446469008677 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 446469008678 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 446469008679 23S rRNA interface [nucleotide binding]; other site 446469008680 putative translocon interaction site; other site 446469008681 signal recognition particle (SRP54) interaction site; other site 446469008682 L23 interface [polypeptide binding]; other site 446469008683 trigger factor interaction site; other site 446469008684 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 446469008685 23S rRNA interface [nucleotide binding]; other site 446469008686 5S rRNA interface [nucleotide binding]; other site 446469008687 putative antibiotic binding site [chemical binding]; other site 446469008688 L25 interface [polypeptide binding]; other site 446469008689 L27 interface [polypeptide binding]; other site 446469008690 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 446469008691 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 446469008692 G-X-X-G motif; other site 446469008693 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 446469008694 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 446469008695 putative translocon binding site; other site 446469008696 protein-rRNA interface [nucleotide binding]; other site 446469008697 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 446469008698 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 446469008699 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 446469008700 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 446469008701 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 446469008702 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 446469008703 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 446469008704 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 446469008705 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 446469008706 elongation factor Tu; Reviewed; Region: PRK00049 446469008707 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 446469008708 G1 box; other site 446469008709 GEF interaction site [polypeptide binding]; other site 446469008710 GTP/Mg2+ binding site [chemical binding]; other site 446469008711 Switch I region; other site 446469008712 G2 box; other site 446469008713 G3 box; other site 446469008714 Switch II region; other site 446469008715 G4 box; other site 446469008716 G5 box; other site 446469008717 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 446469008718 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 446469008719 Antibiotic Binding Site [chemical binding]; other site 446469008720 elongation factor G; Reviewed; Region: PRK00007 446469008721 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 446469008722 G1 box; other site 446469008723 putative GEF interaction site [polypeptide binding]; other site 446469008724 GTP/Mg2+ binding site [chemical binding]; other site 446469008725 Switch I region; other site 446469008726 G2 box; other site 446469008727 G3 box; other site 446469008728 Switch II region; other site 446469008729 G4 box; other site 446469008730 G5 box; other site 446469008731 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 446469008732 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 446469008733 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 446469008734 30S ribosomal protein S7; Validated; Region: PRK05302 446469008735 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 446469008736 S17 interaction site [polypeptide binding]; other site 446469008737 S8 interaction site; other site 446469008738 16S rRNA interaction site [nucleotide binding]; other site 446469008739 streptomycin interaction site [chemical binding]; other site 446469008740 23S rRNA interaction site [nucleotide binding]; other site 446469008741 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 446469008742 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 446469008743 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 446469008744 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 446469008745 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 446469008746 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 446469008747 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 446469008748 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 446469008749 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 446469008750 G-loop; other site 446469008751 DNA binding site [nucleotide binding] 446469008752 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 446469008753 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 446469008754 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 446469008755 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 446469008756 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 446469008757 RPB10 interaction site [polypeptide binding]; other site 446469008758 RPB1 interaction site [polypeptide binding]; other site 446469008759 RPB11 interaction site [polypeptide binding]; other site 446469008760 RPB3 interaction site [polypeptide binding]; other site 446469008761 RPB12 interaction site [polypeptide binding]; other site 446469008762 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 446469008763 core dimer interface [polypeptide binding]; other site 446469008764 peripheral dimer interface [polypeptide binding]; other site 446469008765 L10 interface [polypeptide binding]; other site 446469008766 L11 interface [polypeptide binding]; other site 446469008767 putative EF-Tu interaction site [polypeptide binding]; other site 446469008768 putative EF-G interaction site [polypeptide binding]; other site 446469008769 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 446469008770 23S rRNA interface [nucleotide binding]; other site 446469008771 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 446469008772 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 446469008773 mRNA/rRNA interface [nucleotide binding]; other site 446469008774 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 446469008775 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 446469008776 23S rRNA interface [nucleotide binding]; other site 446469008777 putative thiostrepton binding site; other site 446469008778 L7/L12 interface [polypeptide binding]; other site 446469008779 L25 interface [polypeptide binding]; other site 446469008780 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 446469008781 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 446469008782 putative homodimer interface [polypeptide binding]; other site 446469008783 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 446469008784 heterodimer interface [polypeptide binding]; other site 446469008785 homodimer interface [polypeptide binding]; other site 446469008786 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 446469008787 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446469008788 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446469008789 Walker A/P-loop; other site 446469008790 ATP binding site [chemical binding]; other site 446469008791 Q-loop/lid; other site 446469008792 ABC transporter signature motif; other site 446469008793 Walker B; other site 446469008794 D-loop; other site 446469008795 H-loop/switch region; other site 446469008796 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446469008797 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446469008798 Histidine kinase; Region: HisKA_3; pfam07730 446469008799 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469008800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469008801 active site 446469008802 phosphorylation site [posttranslational modification] 446469008803 intermolecular recognition site; other site 446469008804 dimerization interface [polypeptide binding]; other site 446469008805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469008806 DNA binding residues [nucleotide binding] 446469008807 dimerization interface [polypeptide binding]; other site 446469008808 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 446469008809 adenosine deaminase; Provisional; Region: PRK09358 446469008810 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446469008811 active site 446469008812 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 446469008813 Fe-S cluster binding site [ion binding]; other site 446469008814 DNA binding site [nucleotide binding] 446469008815 active site 446469008816 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446469008817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469008818 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 446469008819 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 446469008820 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 446469008821 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 446469008822 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 446469008823 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 446469008824 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446469008825 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 446469008826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469008827 motif II; other site 446469008828 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 446469008829 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 446469008830 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 446469008831 tetramer interface [polypeptide binding]; other site 446469008832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469008833 catalytic residue [active] 446469008834 Predicted permeases [General function prediction only]; Region: COG0679 446469008835 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 446469008836 MgtE intracellular N domain; Region: MgtE_N; pfam03448 446469008837 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 446469008838 Divalent cation transporter; Region: MgtE; pfam01769 446469008839 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 446469008840 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 446469008841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469008842 ATP binding site [chemical binding]; other site 446469008843 putative Mg++ binding site [ion binding]; other site 446469008844 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469008845 nucleotide binding region [chemical binding]; other site 446469008846 ATP-binding site [chemical binding]; other site 446469008847 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 446469008848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469008849 ATP binding site [chemical binding]; other site 446469008850 putative Mg++ binding site [ion binding]; other site 446469008851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469008852 nucleotide binding region [chemical binding]; other site 446469008853 ATP-binding site [chemical binding]; other site 446469008854 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 446469008855 HRDC domain; Region: HRDC; pfam00570 446469008856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469008857 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469008858 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 446469008859 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 446469008860 putative active site [active] 446469008861 catalytic residue [active] 446469008862 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 446469008863 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 446469008864 5S rRNA interface [nucleotide binding]; other site 446469008865 CTC domain interface [polypeptide binding]; other site 446469008866 L16 interface [polypeptide binding]; other site 446469008867 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 446469008868 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 446469008869 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 446469008870 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446469008871 active site 446469008872 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 446469008873 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 446469008874 Substrate binding site; other site 446469008875 Mg++ binding site; other site 446469008876 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 446469008877 active site 446469008878 substrate binding site [chemical binding]; other site 446469008879 CoA binding site [chemical binding]; other site 446469008880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469008881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469008882 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 446469008883 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 446469008884 Walker A/P-loop; other site 446469008885 ATP binding site [chemical binding]; other site 446469008886 Q-loop/lid; other site 446469008887 ABC transporter signature motif; other site 446469008888 Walker B; other site 446469008889 D-loop; other site 446469008890 H-loop/switch region; other site 446469008891 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 446469008892 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 446469008893 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469008894 MarR family; Region: MarR_2; cl17246 446469008895 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446469008896 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446469008897 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446469008898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469008899 Walker A/P-loop; other site 446469008900 ATP binding site [chemical binding]; other site 446469008901 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469008902 ABC transporter; Region: ABC_tran_2; pfam12848 446469008903 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446469008904 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 446469008905 hydrophobic ligand binding site; other site 446469008906 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 446469008907 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 446469008908 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 446469008909 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 446469008910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469008911 S-adenosylmethionine binding site [chemical binding]; other site 446469008912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 446469008913 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446469008914 G5 domain; Region: G5; pfam07501 446469008915 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 446469008916 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446469008917 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446469008918 G5 domain; Region: G5; pfam07501 446469008919 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446469008920 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446469008921 catalytic residue [active] 446469008922 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 446469008923 active site 446469008924 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 446469008925 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 446469008926 active site 446469008927 HIGH motif; other site 446469008928 KMSKS motif; other site 446469008929 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 446469008930 tRNA binding surface [nucleotide binding]; other site 446469008931 anticodon binding site; other site 446469008932 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446469008933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469008934 ATP binding site [chemical binding]; other site 446469008935 putative Mg++ binding site [ion binding]; other site 446469008936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469008937 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 446469008938 nucleotide binding region [chemical binding]; other site 446469008939 ATP-binding site [chemical binding]; other site 446469008940 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 446469008941 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 446469008942 aminotransferase; Validated; Region: PRK08175 446469008943 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446469008944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469008945 homodimer interface [polypeptide binding]; other site 446469008946 catalytic residue [active] 446469008947 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446469008948 Isochorismatase family; Region: Isochorismatase; pfam00857 446469008949 catalytic triad [active] 446469008950 conserved cis-peptide bond; other site 446469008951 Predicted methyltransferases [General function prediction only]; Region: COG0313 446469008952 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 446469008953 putative SAM binding site [chemical binding]; other site 446469008954 putative homodimer interface [polypeptide binding]; other site 446469008955 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 446469008956 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469008957 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469008958 putative DNA binding site [nucleotide binding]; other site 446469008959 putative Zn2+ binding site [ion binding]; other site 446469008960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469008961 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469008962 putative substrate translocation pore; other site 446469008963 Fatty acid desaturase; Region: FA_desaturase; pfam00487 446469008964 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 446469008965 putative di-iron ligands [ion binding]; other site 446469008966 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469008967 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469008968 DNA binding site [nucleotide binding] 446469008969 domain linker motif; other site 446469008970 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446469008971 Putative glucoamylase; Region: Glycoamylase; pfam10091 446469008972 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446469008973 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446469008974 Walker A/P-loop; other site 446469008975 ATP binding site [chemical binding]; other site 446469008976 Q-loop/lid; other site 446469008977 ABC transporter signature motif; other site 446469008978 Walker B; other site 446469008979 D-loop; other site 446469008980 H-loop/switch region; other site 446469008981 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446469008982 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446469008983 siderophore binding site; other site 446469008984 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446469008985 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446469008986 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469008987 ABC-ATPase subunit interface; other site 446469008988 dimer interface [polypeptide binding]; other site 446469008989 putative PBP binding regions; other site 446469008990 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 446469008991 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446469008992 active site 446469008993 nucleotide binding site [chemical binding]; other site 446469008994 HIGH motif; other site 446469008995 KMSKS motif; other site 446469008996 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446469008997 tRNA binding surface [nucleotide binding]; other site 446469008998 anticodon binding site; other site 446469008999 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446469009000 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446469009001 intersubunit interface [polypeptide binding]; other site 446469009002 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446469009003 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446469009004 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446469009005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446469009006 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446469009007 dimer interface [polypeptide binding]; other site 446469009008 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 446469009009 putative functional site; other site 446469009010 putative MPT binding site; other site 446469009011 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 446469009012 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446469009013 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 446469009014 active site 446469009015 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 446469009016 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 446469009017 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 446469009018 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 446469009019 Part of AAA domain; Region: AAA_19; pfam13245 446469009020 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 446469009021 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 446469009022 PhnA protein; Region: PhnA; pfam03831 446469009023 metabolite-proton symporter; Region: 2A0106; TIGR00883 446469009024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469009025 putative substrate translocation pore; other site 446469009026 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 446469009027 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 446469009028 hydrophobic ligand binding site; other site 446469009029 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 446469009030 Amidinotransferase; Region: Amidinotransf; pfam02274 446469009031 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446469009032 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 446469009033 inhibitor-cofactor binding pocket; inhibition site 446469009034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469009035 catalytic residue [active] 446469009036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469009037 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446469009038 Walker A/P-loop; other site 446469009039 ATP binding site [chemical binding]; other site 446469009040 Q-loop/lid; other site 446469009041 ABC transporter signature motif; other site 446469009042 Walker B; other site 446469009043 D-loop; other site 446469009044 H-loop/switch region; other site 446469009045 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 446469009046 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446469009047 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446469009048 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446469009049 Ligand Binding Site [chemical binding]; other site 446469009050 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446469009051 Ligand Binding Site [chemical binding]; other site 446469009052 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446469009053 NlpC/P60 family; Region: NLPC_P60; pfam00877 446469009054 ydaO/yuaA leader 446469009055 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 446469009056 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 446469009057 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 446469009058 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446469009059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446469009060 catalytic residue [active] 446469009061 H+ Antiporter protein; Region: 2A0121; TIGR00900 446469009062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469009063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469009064 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469009065 MarR family; Region: MarR; pfam01047 446469009066 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446469009067 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 446469009068 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446469009069 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 446469009070 Response regulator receiver domain; Region: Response_reg; pfam00072 446469009071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469009072 active site 446469009073 phosphorylation site [posttranslational modification] 446469009074 intermolecular recognition site; other site 446469009075 dimerization interface [polypeptide binding]; other site 446469009076 Chemotaxis phosphatase CheX; Region: CheX; cl15816 446469009077 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 446469009078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469009079 active site 446469009080 phosphorylation site [posttranslational modification] 446469009081 intermolecular recognition site; other site 446469009082 dimerization interface [polypeptide binding]; other site 446469009083 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 446469009084 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 446469009085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469009086 S-adenosylmethionine binding site [chemical binding]; other site 446469009087 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 446469009088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469009089 active site 446469009090 phosphorylation site [posttranslational modification] 446469009091 intermolecular recognition site; other site 446469009092 dimerization interface [polypeptide binding]; other site 446469009093 CheB methylesterase; Region: CheB_methylest; pfam01339 446469009094 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446469009095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469009096 dimerization interface [polypeptide binding]; other site 446469009097 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469009098 dimer interface [polypeptide binding]; other site 446469009099 putative CheW interface [polypeptide binding]; other site 446469009100 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 446469009101 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 446469009102 putative ligand binding site [chemical binding]; other site 446469009103 HAMP domain; Region: HAMP; pfam00672 446469009104 dimerization interface [polypeptide binding]; other site 446469009105 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446469009106 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469009107 dimer interface [polypeptide binding]; other site 446469009108 putative CheW interface [polypeptide binding]; other site 446469009109 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446469009110 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 446469009111 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469009112 dimer interface [polypeptide binding]; other site 446469009113 putative CheW interface [polypeptide binding]; other site 446469009114 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 446469009115 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446469009116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469009117 dimerization interface [polypeptide binding]; other site 446469009118 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469009119 dimer interface [polypeptide binding]; other site 446469009120 putative CheW interface [polypeptide binding]; other site 446469009121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 446469009122 dimerization interface [polypeptide binding]; other site 446469009123 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446469009124 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469009125 dimer interface [polypeptide binding]; other site 446469009126 putative CheW interface [polypeptide binding]; other site 446469009127 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 446469009128 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 446469009129 putative binding surface; other site 446469009130 active site 446469009131 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 446469009132 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 446469009133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469009134 ATP binding site [chemical binding]; other site 446469009135 Mg2+ binding site [ion binding]; other site 446469009136 G-X-G motif; other site 446469009137 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 446469009138 CheW-like domain; Region: CheW; pfam01584 446469009139 Global regulator protein family; Region: CsrA; pfam02599 446469009140 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 446469009141 FHIPEP family; Region: FHIPEP; pfam00771 446469009142 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 446469009143 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 446469009144 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 446469009145 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 446469009146 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 446469009147 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 446469009148 flagellar motor switch protein FliN; Region: fliN; TIGR02480 446469009149 Flagellar motor switch protein FliM; Region: FliM; pfam02154 446469009150 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 446469009151 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 446469009152 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 446469009153 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 446469009154 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 446469009155 ligand binding site [chemical binding]; other site 446469009156 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 446469009157 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 446469009158 Flagellar protein (FlbD); Region: FlbD; pfam06289 446469009159 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 446469009160 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 446469009161 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 446469009162 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 446469009163 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 446469009164 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446469009165 NlpC/P60 family; Region: NLPC_P60; pfam00877 446469009166 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 446469009167 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446469009168 Walker A motif; other site 446469009169 ATP binding site [chemical binding]; other site 446469009170 Walker B motif; other site 446469009171 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 446469009172 FliG C-terminal domain; Region: FliG_C; pfam01706 446469009173 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 446469009174 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 446469009175 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 446469009176 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 446469009177 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 446469009178 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 446469009179 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 446469009180 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 446469009181 Flagellar protein FliS; Region: FliS; cl00654 446469009182 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 446469009183 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 446469009184 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 446469009185 flagellin; Reviewed; Region: PRK08869 446469009186 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 446469009187 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 446469009188 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446469009189 active site 446469009190 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 446469009191 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446469009192 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469009193 DNA binding residues [nucleotide binding] 446469009194 FlgN protein; Region: FlgN; pfam05130 446469009195 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 446469009196 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 446469009197 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 446469009198 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 446469009199 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 446469009200 FliW protein; Region: FliW; pfam02623 446469009201 HDOD domain; Region: HDOD; pfam08668 446469009202 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 446469009203 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446469009204 DNA-binding site [nucleotide binding]; DNA binding site 446469009205 RNA-binding motif; other site 446469009206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469009207 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446469009208 NAD(P) binding site [chemical binding]; other site 446469009209 active site 446469009210 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 446469009211 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 446469009212 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 446469009213 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446469009214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469009215 ATP binding site [chemical binding]; other site 446469009216 putative Mg++ binding site [ion binding]; other site 446469009217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469009218 nucleotide binding region [chemical binding]; other site 446469009219 ATP-binding site [chemical binding]; other site 446469009220 Repair protein; Region: Repair_PSII; pfam04536 446469009221 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 446469009222 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446469009223 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 446469009224 conserved cys residue [active] 446469009225 LabA_like proteins; Region: LabA_like; cd06167 446469009226 putative metal binding site [ion binding]; other site 446469009227 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469009228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469009229 active site 446469009230 phosphorylation site [posttranslational modification] 446469009231 intermolecular recognition site; other site 446469009232 dimerization interface [polypeptide binding]; other site 446469009233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469009234 DNA binding site [nucleotide binding] 446469009235 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 446469009236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469009237 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469009238 dimerization interface [polypeptide binding]; other site 446469009239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469009240 dimer interface [polypeptide binding]; other site 446469009241 phosphorylation site [posttranslational modification] 446469009242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469009243 ATP binding site [chemical binding]; other site 446469009244 Mg2+ binding site [ion binding]; other site 446469009245 G-X-G motif; other site 446469009246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 446469009247 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 446469009248 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 446469009249 Ca binding site [ion binding]; other site 446469009250 active site 446469009251 catalytic site [active] 446469009252 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446469009253 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469009254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469009255 dimer interface [polypeptide binding]; other site 446469009256 conserved gate region; other site 446469009257 putative PBP binding loops; other site 446469009258 ABC-ATPase subunit interface; other site 446469009259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469009260 dimer interface [polypeptide binding]; other site 446469009261 conserved gate region; other site 446469009262 putative PBP binding loops; other site 446469009263 ABC-ATPase subunit interface; other site 446469009264 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469009265 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469009266 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 446469009267 Melibiase; Region: Melibiase; pfam02065 446469009268 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469009269 MarR family; Region: MarR_2; cl17246 446469009270 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469009271 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446469009272 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446469009273 active site 446469009274 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 446469009275 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 446469009276 ring oligomerisation interface [polypeptide binding]; other site 446469009277 ATP/Mg binding site [chemical binding]; other site 446469009278 stacking interactions; other site 446469009279 hinge regions; other site 446469009280 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 446469009281 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 446469009282 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 446469009283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446469009284 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 446469009285 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 446469009286 ligand binding site [chemical binding]; other site 446469009287 active site 446469009288 UGI interface [polypeptide binding]; other site 446469009289 catalytic site [active] 446469009290 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 446469009291 active site 446469009292 catalytic triad [active] 446469009293 oxyanion hole [active] 446469009294 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 446469009295 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 446469009296 catalytic residues [active] 446469009297 Thioredoxin; Region: Thioredoxin_4; cl17273 446469009298 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446469009299 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446469009300 active site 446469009301 ATP binding site [chemical binding]; other site 446469009302 substrate binding site [chemical binding]; other site 446469009303 activation loop (A-loop); other site 446469009304 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 446469009305 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 446469009306 active site 446469009307 homotetramer interface [polypeptide binding]; other site 446469009308 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 446469009309 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 446469009310 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446469009311 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 446469009312 Walker A/P-loop; other site 446469009313 ATP binding site [chemical binding]; other site 446469009314 Q-loop/lid; other site 446469009315 ABC transporter signature motif; other site 446469009316 Walker B; other site 446469009317 D-loop; other site 446469009318 H-loop/switch region; other site 446469009319 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 446469009320 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 446469009321 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446469009322 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 446469009323 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446469009324 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 446469009325 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446469009326 active site 446469009327 HIGH motif; other site 446469009328 nucleotide binding site [chemical binding]; other site 446469009329 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 446469009330 KMSKS motif; other site 446469009331 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446469009332 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 446469009333 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446469009334 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446469009335 catalytic residue [active] 446469009336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469009337 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 446469009338 FAD binding domain; Region: FAD_binding_4; pfam01565 446469009339 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 446469009340 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446469009341 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446469009342 dimer interface [polypeptide binding]; other site 446469009343 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 446469009344 homotrimer interaction site [polypeptide binding]; other site 446469009345 zinc binding site [ion binding]; other site 446469009346 CDP-binding sites; other site 446469009347 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 446469009348 substrate binding site; other site 446469009349 dimer interface; other site 446469009350 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 446469009351 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 446469009352 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 446469009353 Walker A/P-loop; other site 446469009354 ATP binding site [chemical binding]; other site 446469009355 Q-loop/lid; other site 446469009356 ABC transporter signature motif; other site 446469009357 Walker B; other site 446469009358 D-loop; other site 446469009359 H-loop/switch region; other site 446469009360 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 446469009361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469009362 dimer interface [polypeptide binding]; other site 446469009363 conserved gate region; other site 446469009364 putative PBP binding loops; other site 446469009365 ABC-ATPase subunit interface; other site 446469009366 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 446469009367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469009368 dimer interface [polypeptide binding]; other site 446469009369 conserved gate region; other site 446469009370 putative PBP binding loops; other site 446469009371 ABC-ATPase subunit interface; other site 446469009372 PBP superfamily domain; Region: PBP_like_2; cl17296 446469009373 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469009374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469009375 active site 446469009376 phosphorylation site [posttranslational modification] 446469009377 intermolecular recognition site; other site 446469009378 dimerization interface [polypeptide binding]; other site 446469009379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469009380 DNA binding site [nucleotide binding] 446469009381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469009382 dimer interface [polypeptide binding]; other site 446469009383 phosphorylation site [posttranslational modification] 446469009384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469009385 ATP binding site [chemical binding]; other site 446469009386 Mg2+ binding site [ion binding]; other site 446469009387 G-X-G motif; other site 446469009388 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 446469009389 PhoU domain; Region: PhoU; pfam01895 446469009390 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446469009391 catalytic core [active] 446469009392 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 446469009393 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 446469009394 putative ADP-binding pocket [chemical binding]; other site 446469009395 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446469009396 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 446469009397 Lsr2; Region: Lsr2; pfam11774 446469009398 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 446469009399 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 446469009400 dimer interface [polypeptide binding]; other site 446469009401 putative anticodon binding site; other site 446469009402 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446469009403 motif 1; other site 446469009404 dimer interface [polypeptide binding]; other site 446469009405 active site 446469009406 motif 2; other site 446469009407 motif 3; other site 446469009408 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 446469009409 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 446469009410 dimerization interface [polypeptide binding]; other site 446469009411 active site 446469009412 L-aspartate oxidase; Provisional; Region: PRK07804 446469009413 L-aspartate oxidase; Provisional; Region: PRK06175 446469009414 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446469009415 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 446469009416 tetramerization interface [polypeptide binding]; other site 446469009417 active site 446469009418 pantoate--beta-alanine ligase; Region: panC; TIGR00018 446469009419 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446469009420 active site 446469009421 nucleotide binding site [chemical binding]; other site 446469009422 HIGH motif; other site 446469009423 KMSKS motif; other site 446469009424 Rossmann-like domain; Region: Rossmann-like; pfam10727 446469009425 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 446469009426 Bacterial PH domain; Region: DUF304; pfam03703 446469009427 Bacterial PH domain; Region: DUF304; cl01348 446469009428 Bacterial PH domain; Region: DUF304; cl01348 446469009429 Bacterial PH domain; Region: DUF304; cl01348 446469009430 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 446469009431 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 446469009432 homooctamer interface [polypeptide binding]; other site 446469009433 active site 446469009434 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 446469009435 catalytic center binding site [active] 446469009436 ATP binding site [chemical binding]; other site 446469009437 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 446469009438 dihydropteroate synthase; Region: DHPS; TIGR01496 446469009439 substrate binding pocket [chemical binding]; other site 446469009440 dimer interface [polypeptide binding]; other site 446469009441 inhibitor binding site; inhibition site 446469009442 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 446469009443 homodecamer interface [polypeptide binding]; other site 446469009444 GTP cyclohydrolase I; Provisional; Region: PLN03044 446469009445 active site 446469009446 putative catalytic site residues [active] 446469009447 zinc binding site [ion binding]; other site 446469009448 GTP-CH-I/GFRP interaction surface; other site 446469009449 FtsH Extracellular; Region: FtsH_ext; pfam06480 446469009450 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 446469009451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469009452 Walker A motif; other site 446469009453 ATP binding site [chemical binding]; other site 446469009454 Walker B motif; other site 446469009455 arginine finger; other site 446469009456 Peptidase family M41; Region: Peptidase_M41; pfam01434 446469009457 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446469009458 active site 446469009459 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 446469009460 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 446469009461 Ligand Binding Site [chemical binding]; other site 446469009462 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 446469009463 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 446469009464 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 446469009465 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 446469009466 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 446469009467 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 446469009468 dimer interface [polypeptide binding]; other site 446469009469 substrate binding site [chemical binding]; other site 446469009470 metal binding sites [ion binding]; metal-binding site 446469009471 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446469009472 NlpC/P60 family; Region: NLPC_P60; pfam00877 446469009473 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 446469009474 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446469009475 homodimer interface [polypeptide binding]; other site 446469009476 substrate-cofactor binding pocket; other site 446469009477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469009478 catalytic residue [active] 446469009479 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 446469009480 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 446469009481 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446469009482 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446469009483 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446469009484 NAD(P) binding site [chemical binding]; other site 446469009485 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446469009486 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446469009487 Domain of unknown function DUF77; Region: DUF77; pfam01910 446469009488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469009489 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446469009490 NAD(P) binding site [chemical binding]; other site 446469009491 active site 446469009492 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446469009493 FAD binding domain; Region: FAD_binding_4; pfam01565 446469009494 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 446469009495 Cysteine-rich domain; Region: CCG; pfam02754 446469009496 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 446469009497 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 446469009498 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446469009499 active site 446469009500 nucleotide binding site [chemical binding]; other site 446469009501 HIGH motif; other site 446469009502 KMSKS motif; other site 446469009503 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 446469009504 MoxR-like ATPases [General function prediction only]; Region: COG0714 446469009505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446469009506 Peptidase family M48; Region: Peptidase_M48; cl12018 446469009507 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 446469009508 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446469009509 AMP binding site [chemical binding]; other site 446469009510 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446469009511 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446469009512 Walker A/P-loop; other site 446469009513 ATP binding site [chemical binding]; other site 446469009514 Q-loop/lid; other site 446469009515 ABC transporter signature motif; other site 446469009516 Walker B; other site 446469009517 D-loop; other site 446469009518 H-loop/switch region; other site 446469009519 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446469009520 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446469009521 FtsX-like permease family; Region: FtsX; pfam02687 446469009522 FtsX-like permease family; Region: FtsX; pfam02687 446469009523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469009524 dimerization interface [polypeptide binding]; other site 446469009525 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446469009526 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469009527 dimer interface [polypeptide binding]; other site 446469009528 putative CheW interface [polypeptide binding]; other site 446469009529 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446469009530 dimerization interface [polypeptide binding]; other site 446469009531 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446469009532 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469009533 dimer interface [polypeptide binding]; other site 446469009534 putative CheW interface [polypeptide binding]; other site 446469009535 Predicted membrane protein [Function unknown]; Region: COG1511 446469009536 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 446469009537 Predicted membrane protein [Function unknown]; Region: COG1511 446469009538 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 446469009539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469009540 Walker A/P-loop; other site 446469009541 ATP binding site [chemical binding]; other site 446469009542 Q-loop/lid; other site 446469009543 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469009544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469009545 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 446469009546 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 446469009547 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446469009548 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446469009549 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 446469009550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469009551 putative substrate translocation pore; other site 446469009552 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446469009553 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 446469009554 Domain of unknown function (DUF955); Region: DUF955; pfam06114 446469009555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446469009556 salt bridge; other site 446469009557 non-specific DNA binding site [nucleotide binding]; other site 446469009558 sequence-specific DNA binding site [nucleotide binding]; other site 446469009559 Transcription factor WhiB; Region: Whib; pfam02467 446469009560 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 446469009561 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446469009562 TAP-like protein; Region: Abhydrolase_4; pfam08386 446469009563 DNA polymerase III subunit delta'; Validated; Region: PRK07940 446469009564 DNA polymerase III subunit delta'; Validated; Region: PRK08485 446469009565 thymidylate kinase; Validated; Region: tmk; PRK00698 446469009566 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 446469009567 TMP-binding site; other site 446469009568 ATP-binding site [chemical binding]; other site 446469009569 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446469009570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469009571 active site 446469009572 motif I; other site 446469009573 motif II; other site 446469009574 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446469009575 MarR family; Region: MarR; pfam01047 446469009576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446469009577 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446469009578 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446469009579 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446469009580 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446469009581 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 446469009582 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446469009583 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446469009584 Ligand binding site; other site 446469009585 Putative Catalytic site; other site 446469009586 DXD motif; other site 446469009587 C-terminal putative kinase domain of FAM20 (family with sequence similarity 20), Drosophila Four-jointed (Fj), and related proteins; Region: FAM20_C_like; cl05973 446469009588 putative catalytic loop [active] 446469009589 putative catalytic residues [active] 446469009590 putative metal binding site [ion binding]; other site 446469009591 putative activation loop; other site 446469009592 GtrA-like protein; Region: GtrA; pfam04138 446469009593 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 446469009594 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 446469009595 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 446469009596 active site 446469009597 interdomain interaction site; other site 446469009598 putative metal-binding site [ion binding]; other site 446469009599 nucleotide binding site [chemical binding]; other site 446469009600 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 446469009601 domain I; other site 446469009602 phosphate binding site [ion binding]; other site 446469009603 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 446469009604 domain II; other site 446469009605 domain III; other site 446469009606 nucleotide binding site [chemical binding]; other site 446469009607 DNA binding groove [nucleotide binding] 446469009608 catalytic site [active] 446469009609 domain IV; other site 446469009610 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446469009611 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446469009612 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446469009613 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 446469009614 active site 446469009615 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469009616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469009617 active site 446469009618 phosphorylation site [posttranslational modification] 446469009619 intermolecular recognition site; other site 446469009620 dimerization interface [polypeptide binding]; other site 446469009621 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469009622 DNA binding site [nucleotide binding] 446469009623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469009624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469009625 dimer interface [polypeptide binding]; other site 446469009626 phosphorylation site [posttranslational modification] 446469009627 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469009628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469009629 ATP binding site [chemical binding]; other site 446469009630 Mg2+ binding site [ion binding]; other site 446469009631 G-X-G motif; other site 446469009632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469009633 S-adenosylmethionine binding site [chemical binding]; other site 446469009634 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446469009635 putative metal binding site [ion binding]; other site 446469009636 putative catalytic site [active] 446469009637 putative phosphate binding site [ion binding]; other site 446469009638 putative metal binding site [ion binding]; other site 446469009639 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 446469009640 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 446469009641 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446469009642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469009643 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469009644 DNA binding residues [nucleotide binding] 446469009645 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446469009646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469009647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469009648 DNA binding residues [nucleotide binding] 446469009649 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446469009650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469009651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446469009652 DNA binding residues [nucleotide binding] 446469009653 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 446469009654 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 446469009655 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 446469009656 active site 446469009657 SAM binding site [chemical binding]; other site 446469009658 homodimer interface [polypeptide binding]; other site 446469009659 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 446469009660 nitrite reductase subunit NirD; Provisional; Region: PRK14989 446469009661 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446469009662 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446469009663 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446469009664 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446469009665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446469009666 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 446469009667 galactokinase; Provisional; Region: PRK03817 446469009668 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 446469009669 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 446469009670 dimer interface [polypeptide binding]; other site 446469009671 active site 446469009672 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 446469009673 Melibiase; Region: Melibiase; pfam02065 446469009674 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469009675 putative DNA binding site [nucleotide binding]; other site 446469009676 putative Zn2+ binding site [ion binding]; other site 446469009677 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446469009678 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446469009679 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 446469009680 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 446469009681 Phosphotransferase enzyme family; Region: APH; pfam01636 446469009682 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446469009683 substrate binding site [chemical binding]; other site 446469009684 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469009685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469009686 active site 446469009687 phosphorylation site [posttranslational modification] 446469009688 intermolecular recognition site; other site 446469009689 dimerization interface [polypeptide binding]; other site 446469009690 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469009691 DNA binding residues [nucleotide binding] 446469009692 dimerization interface [polypeptide binding]; other site 446469009693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446469009694 Histidine kinase; Region: HisKA_3; pfam07730 446469009695 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446469009696 ATP binding site [chemical binding]; other site 446469009697 Mg2+ binding site [ion binding]; other site 446469009698 G-X-G motif; other site 446469009699 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446469009700 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469009701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469009702 Walker A/P-loop; other site 446469009703 ATP binding site [chemical binding]; other site 446469009704 Q-loop/lid; other site 446469009705 ABC transporter signature motif; other site 446469009706 Walker B; other site 446469009707 D-loop; other site 446469009708 H-loop/switch region; other site 446469009709 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 446469009710 Flavoprotein; Region: Flavoprotein; pfam02441 446469009711 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 446469009712 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 446469009713 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446469009714 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446469009715 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446469009716 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446469009717 Walker A/P-loop; other site 446469009718 ATP binding site [chemical binding]; other site 446469009719 Q-loop/lid; other site 446469009720 ABC transporter signature motif; other site 446469009721 Walker B; other site 446469009722 D-loop; other site 446469009723 H-loop/switch region; other site 446469009724 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446469009725 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 446469009726 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446469009727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446469009728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469009729 S-adenosylmethionine binding site [chemical binding]; other site 446469009730 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 446469009731 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 446469009732 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469009733 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469009734 DNA binding site [nucleotide binding] 446469009735 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 446469009736 putative dimerization interface [polypeptide binding]; other site 446469009737 putative ligand binding site [chemical binding]; other site 446469009738 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 446469009739 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446469009740 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446469009741 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446469009742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469009743 dimer interface [polypeptide binding]; other site 446469009744 conserved gate region; other site 446469009745 putative PBP binding loops; other site 446469009746 ABC-ATPase subunit interface; other site 446469009747 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446469009748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469009749 conserved gate region; other site 446469009750 dimer interface [polypeptide binding]; other site 446469009751 ABC-ATPase subunit interface; other site 446469009752 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446469009753 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446469009754 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 446469009755 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446469009756 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446469009757 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446469009758 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 446469009759 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 446469009760 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 446469009761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446469009762 ATP binding site [chemical binding]; other site 446469009763 putative Mg++ binding site [ion binding]; other site 446469009764 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 446469009765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469009766 nucleotide binding region [chemical binding]; other site 446469009767 ATP-binding site [chemical binding]; other site 446469009768 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 446469009769 Fic family protein [Function unknown]; Region: COG3177 446469009770 Fic/DOC family; Region: Fic; pfam02661 446469009771 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 446469009772 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446469009773 metal binding site [ion binding]; metal-binding site 446469009774 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 446469009775 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 446469009776 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 446469009777 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 446469009778 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 446469009779 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 446469009780 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446469009781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469009782 homodimer interface [polypeptide binding]; other site 446469009783 catalytic residue [active] 446469009784 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 446469009785 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 446469009786 ATP binding site [chemical binding]; other site 446469009787 Walker A motif; other site 446469009788 hexamer interface [polypeptide binding]; other site 446469009789 Walker B motif; other site 446469009790 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 446469009791 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446469009792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469009793 motif II; other site 446469009794 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 446469009795 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446469009796 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 446469009797 Malic enzyme, N-terminal domain; Region: malic; pfam00390 446469009798 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 446469009799 putative NAD(P) binding site [chemical binding]; other site 446469009800 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446469009801 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 446469009802 active site 446469009803 FMN binding site [chemical binding]; other site 446469009804 substrate binding site [chemical binding]; other site 446469009805 homotetramer interface [polypeptide binding]; other site 446469009806 catalytic residue [active] 446469009807 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 446469009808 AAA ATPase domain; Region: AAA_16; pfam13191 446469009809 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469009810 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469009811 DNA binding residues [nucleotide binding] 446469009812 dimerization interface [polypeptide binding]; other site 446469009813 acetyl-CoA synthetase; Provisional; Region: PRK00174 446469009814 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 446469009815 active site 446469009816 CoA binding site [chemical binding]; other site 446469009817 acyl-activating enzyme (AAE) consensus motif; other site 446469009818 AMP binding site [chemical binding]; other site 446469009819 acetate binding site [chemical binding]; other site 446469009820 Proline dehydrogenase; Region: Pro_dh; cl03282 446469009821 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446469009822 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446469009823 NAD(P) binding site [chemical binding]; other site 446469009824 catalytic residues [active] 446469009825 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 446469009826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469009827 Coenzyme A binding pocket [chemical binding]; other site 446469009828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469009829 Coenzyme A binding pocket [chemical binding]; other site 446469009830 polyphosphate kinase; Provisional; Region: PRK05443 446469009831 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 446469009832 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 446469009833 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 446469009834 putative domain interface [polypeptide binding]; other site 446469009835 putative active site [active] 446469009836 catalytic site [active] 446469009837 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 446469009838 putative domain interface [polypeptide binding]; other site 446469009839 putative active site [active] 446469009840 catalytic site [active] 446469009841 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 446469009842 active site 446469009843 Ap6A binding site [chemical binding]; other site 446469009844 nudix motif; other site 446469009845 metal binding site [ion binding]; metal-binding site 446469009846 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446469009847 catalytic core [active] 446469009848 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 446469009849 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 446469009850 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 446469009851 generic binding surface I; other site 446469009852 generic binding surface II; other site 446469009853 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 446469009854 putative active site [active] 446469009855 putative catalytic site [active] 446469009856 putative Mg binding site IVb [ion binding]; other site 446469009857 putative phosphate binding site [ion binding]; other site 446469009858 putative DNA binding site [nucleotide binding]; other site 446469009859 putative Mg binding site IVa [ion binding]; other site 446469009860 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 446469009861 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 446469009862 putative active site [active] 446469009863 putative metal binding site [ion binding]; other site 446469009864 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 446469009865 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 446469009866 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 446469009867 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446469009868 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 446469009869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469009870 Walker A/P-loop; other site 446469009871 ATP binding site [chemical binding]; other site 446469009872 Q-loop/lid; other site 446469009873 ABC transporter signature motif; other site 446469009874 Walker B; other site 446469009875 D-loop; other site 446469009876 H-loop/switch region; other site 446469009877 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 446469009878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469009879 putative substrate translocation pore; other site 446469009880 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469009881 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 446469009882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469009883 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469009884 putative substrate translocation pore; other site 446469009885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469009886 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446469009887 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469009888 methionine sulfoxide reductase B; Provisional; Region: PRK00222 446469009889 SelR domain; Region: SelR; pfam01641 446469009890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469009891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469009892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469009893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469009894 putative substrate translocation pore; other site 446469009895 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 446469009896 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446469009897 ATP binding site [chemical binding]; other site 446469009898 putative Mg++ binding site [ion binding]; other site 446469009899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446469009900 nucleotide binding region [chemical binding]; other site 446469009901 ATP-binding site [chemical binding]; other site 446469009902 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 446469009903 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 446469009904 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 446469009905 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469009906 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469009907 putative Zn2+ binding site [ion binding]; other site 446469009908 putative DNA binding site [nucleotide binding]; other site 446469009909 dimerization interface [polypeptide binding]; other site 446469009910 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 446469009911 putative dimer interface [polypeptide binding]; other site 446469009912 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446469009913 PASTA domain; Region: PASTA; pfam03793 446469009914 Predicted transcriptional regulators [Transcription]; Region: COG1695 446469009915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469009916 putative Zn2+ binding site [ion binding]; other site 446469009917 putative DNA binding site [nucleotide binding]; other site 446469009918 Predicted membrane protein [Function unknown]; Region: COG4709 446469009919 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 446469009920 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 446469009921 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 446469009922 Mechanosensitive ion channel; Region: MS_channel; pfam00924 446469009923 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 446469009924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446469009925 active site 446469009926 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 446469009927 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 446469009928 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 446469009929 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 446469009930 putative metal binding site [ion binding]; other site 446469009931 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 446469009932 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 446469009933 putative metal binding site [ion binding]; other site 446469009934 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 446469009935 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 446469009936 putative metal binding site [ion binding]; other site 446469009937 hypothetical protein; Provisional; Region: PRK14013 446469009938 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 446469009939 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 446469009940 putative metal binding site [ion binding]; other site 446469009941 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 446469009942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469009943 NAD(P) binding site [chemical binding]; other site 446469009944 active site 446469009945 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 446469009946 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 446469009947 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 446469009948 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446469009949 DNA binding residues [nucleotide binding] 446469009950 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 446469009951 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 446469009952 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 446469009953 dimerization interface [polypeptide binding]; other site 446469009954 putative ATP binding site [chemical binding]; other site 446469009955 amidophosphoribosyltransferase; Provisional; Region: PRK07847 446469009956 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 446469009957 active site 446469009958 tetramer interface [polypeptide binding]; other site 446469009959 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446469009960 active site 446469009961 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 446469009962 Catalytic site [active] 446469009963 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469009964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469009965 DNA binding residues [nucleotide binding] 446469009966 dimerization interface [polypeptide binding]; other site 446469009967 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 446469009968 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446469009969 active site 446469009970 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446469009971 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 446469009972 DNA binding residues [nucleotide binding] 446469009973 dimer interface [polypeptide binding]; other site 446469009974 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 446469009975 RNB domain; Region: RNB; pfam00773 446469009976 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 446469009977 glutamate dehydrogenase; Provisional; Region: PRK09414 446469009978 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 446469009979 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 446469009980 NAD(P) binding site [chemical binding]; other site 446469009981 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446469009982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469009983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446469009984 Coenzyme A binding pocket [chemical binding]; other site 446469009985 mannonate dehydratase; Region: uxuA; TIGR00695 446469009986 mannonate dehydratase; Provisional; Region: PRK03906 446469009987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469009988 Coenzyme A binding pocket [chemical binding]; other site 446469009989 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 446469009990 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446469009991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446469009992 Putative zinc-finger; Region: zf-HC2; pfam13490 446469009993 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 446469009994 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446469009995 active site residue [active] 446469009996 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446469009997 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469009998 Walker A/P-loop; other site 446469009999 ATP binding site [chemical binding]; other site 446469010000 Q-loop/lid; other site 446469010001 ABC transporter signature motif; other site 446469010002 Walker B; other site 446469010003 D-loop; other site 446469010004 H-loop/switch region; other site 446469010005 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469010006 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469010007 Walker A/P-loop; other site 446469010008 ATP binding site [chemical binding]; other site 446469010009 Q-loop/lid; other site 446469010010 ABC transporter signature motif; other site 446469010011 Walker B; other site 446469010012 D-loop; other site 446469010013 H-loop/switch region; other site 446469010014 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469010015 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446469010016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469010017 ABC-ATPase subunit interface; other site 446469010018 putative PBP binding loops; other site 446469010019 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446469010020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469010021 dimer interface [polypeptide binding]; other site 446469010022 conserved gate region; other site 446469010023 putative PBP binding loops; other site 446469010024 ABC-ATPase subunit interface; other site 446469010025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446469010026 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446469010027 putative dimerization interface [polypeptide binding]; other site 446469010028 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 446469010029 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446469010030 hypothetical protein; Provisional; Region: PRK07906 446469010031 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 446469010032 putative metal binding site [ion binding]; other site 446469010033 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 446469010034 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 446469010035 active site 446469010036 catalytic site [active] 446469010037 Zn binding site [ion binding]; other site 446469010038 tetramer interface [polypeptide binding]; other site 446469010039 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446469010040 classical (c) SDRs; Region: SDR_c; cd05233 446469010041 NAD(P) binding site [chemical binding]; other site 446469010042 active site 446469010043 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 446469010044 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 446469010045 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446469010046 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 446469010047 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 446469010048 active site 446469010049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469010050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469010051 Predicted flavoprotein [General function prediction only]; Region: COG0431 446469010052 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446469010053 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 446469010054 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446469010055 NAD(P) binding site [chemical binding]; other site 446469010056 active site 446469010057 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 446469010058 metal binding site [ion binding]; metal-binding site 446469010059 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 446469010060 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446469010061 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446469010062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469010063 Coenzyme A binding pocket [chemical binding]; other site 446469010064 Abi-like protein; Region: Abi_2; pfam07751 446469010065 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446469010066 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446469010067 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446469010068 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 446469010069 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 446469010070 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 446469010071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469010072 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446469010073 homotrimer interaction site [polypeptide binding]; other site 446469010074 putative active site [active] 446469010075 Predicted transcriptional regulators [Transcription]; Region: COG1733 446469010076 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446469010077 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 446469010078 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446469010079 amidase catalytic site [active] 446469010080 Zn binding residues [ion binding]; other site 446469010081 substrate binding site [chemical binding]; other site 446469010082 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 446469010083 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446469010084 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 446469010085 active site 446469010086 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446469010087 dimer interface [polypeptide binding]; other site 446469010088 non-prolyl cis peptide bond; other site 446469010089 insertion regions; other site 446469010090 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446469010091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469010092 Coenzyme A binding pocket [chemical binding]; other site 446469010093 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 446469010094 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446469010095 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446469010096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446469010097 substrate binding pocket [chemical binding]; other site 446469010098 membrane-bound complex binding site; other site 446469010099 hinge residues; other site 446469010100 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446469010101 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446469010102 Walker A/P-loop; other site 446469010103 ATP binding site [chemical binding]; other site 446469010104 Q-loop/lid; other site 446469010105 ABC transporter signature motif; other site 446469010106 Walker B; other site 446469010107 D-loop; other site 446469010108 H-loop/switch region; other site 446469010109 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469010110 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446469010111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469010112 dimer interface [polypeptide binding]; other site 446469010113 conserved gate region; other site 446469010114 putative PBP binding loops; other site 446469010115 ABC-ATPase subunit interface; other site 446469010116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469010117 Coenzyme A binding pocket [chemical binding]; other site 446469010118 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 446469010119 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 446469010120 active site 446469010121 non-prolyl cis peptide bond; other site 446469010122 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446469010123 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 446469010124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469010125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469010126 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446469010127 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446469010128 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 446469010129 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 446469010130 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 446469010131 dimerization interface [polypeptide binding]; other site 446469010132 ATP binding site [chemical binding]; other site 446469010133 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 446469010134 dimerization interface [polypeptide binding]; other site 446469010135 ATP binding site [chemical binding]; other site 446469010136 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 446469010137 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 446469010138 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 446469010139 NAD binding site [chemical binding]; other site 446469010140 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469010141 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469010142 DNA binding site [nucleotide binding] 446469010143 domain linker motif; other site 446469010144 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469010145 ligand binding site [chemical binding]; other site 446469010146 dimerization interface [polypeptide binding]; other site 446469010147 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446469010148 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446469010149 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 446469010150 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 446469010151 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 446469010152 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 446469010153 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 446469010154 RNA binding site [nucleotide binding]; other site 446469010155 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 446469010156 active site 446469010157 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446469010158 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 446469010159 FMN binding site [chemical binding]; other site 446469010160 active site 446469010161 substrate binding site [chemical binding]; other site 446469010162 catalytic residue [active] 446469010163 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 446469010164 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 446469010165 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446469010166 active site 446469010167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469010168 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446469010169 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469010170 Walker A/P-loop; other site 446469010171 ATP binding site [chemical binding]; other site 446469010172 Q-loop/lid; other site 446469010173 ABC transporter signature motif; other site 446469010174 Walker B; other site 446469010175 D-loop; other site 446469010176 H-loop/switch region; other site 446469010177 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469010178 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446469010179 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446469010180 Walker A/P-loop; other site 446469010181 ATP binding site [chemical binding]; other site 446469010182 Q-loop/lid; other site 446469010183 ABC transporter signature motif; other site 446469010184 Walker B; other site 446469010185 D-loop; other site 446469010186 H-loop/switch region; other site 446469010187 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446469010188 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 446469010189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469010190 dimer interface [polypeptide binding]; other site 446469010191 conserved gate region; other site 446469010192 putative PBP binding loops; other site 446469010193 ABC-ATPase subunit interface; other site 446469010194 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446469010195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469010196 dimer interface [polypeptide binding]; other site 446469010197 conserved gate region; other site 446469010198 putative PBP binding loops; other site 446469010199 ABC-ATPase subunit interface; other site 446469010200 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446469010201 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446469010202 substrate binding site [chemical binding]; other site 446469010203 CutC family; Region: CutC; cl01218 446469010204 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 446469010205 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446469010206 dimer interface [polypeptide binding]; other site 446469010207 active site 446469010208 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 446469010209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469010210 NAD(P) binding site [chemical binding]; other site 446469010211 active site 446469010212 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446469010213 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446469010214 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446469010215 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 446469010216 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 446469010217 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446469010218 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446469010219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446469010220 catalytic residue [active] 446469010221 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 446469010222 active site residue [active] 446469010223 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 446469010224 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446469010225 homodimer interface [polypeptide binding]; other site 446469010226 substrate-cofactor binding pocket; other site 446469010227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469010228 catalytic residue [active] 446469010229 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 446469010230 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 446469010231 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 446469010232 putative active site [active] 446469010233 catalytic triad [active] 446469010234 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 446469010235 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 446469010236 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446469010237 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446469010238 FAD binding pocket [chemical binding]; other site 446469010239 FAD binding motif [chemical binding]; other site 446469010240 phosphate binding motif [ion binding]; other site 446469010241 NAD binding pocket [chemical binding]; other site 446469010242 Predicted transcriptional regulators [Transcription]; Region: COG1695 446469010243 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446469010244 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 446469010245 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 446469010246 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 446469010247 ATP binding site [chemical binding]; other site 446469010248 active site 446469010249 substrate binding site [chemical binding]; other site 446469010250 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 446469010251 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 446469010252 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 446469010253 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 446469010254 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 446469010255 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 446469010256 GDP-binding site [chemical binding]; other site 446469010257 ACT binding site; other site 446469010258 IMP binding site; other site 446469010259 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 446469010260 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446469010261 anti sigma factor interaction site; other site 446469010262 regulatory phosphorylation site [posttranslational modification]; other site 446469010263 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 446469010264 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 446469010265 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 446469010266 PAS domain; Region: PAS_9; pfam13426 446469010267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446469010268 putative active site [active] 446469010269 heme pocket [chemical binding]; other site 446469010270 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446469010271 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446469010272 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446469010273 anti sigma factor interaction site; other site 446469010274 regulatory phosphorylation site [posttranslational modification]; other site 446469010275 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 446469010276 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 446469010277 active site 446469010278 intersubunit interface [polypeptide binding]; other site 446469010279 zinc binding site [ion binding]; other site 446469010280 Na+ binding site [ion binding]; other site 446469010281 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 446469010282 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446469010283 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446469010284 UMP phosphatase; Provisional; Region: PRK10444 446469010285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469010286 active site 446469010287 motif I; other site 446469010288 motif II; other site 446469010289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469010290 Htaa; Region: HtaA; pfam04213 446469010291 Htaa; Region: HtaA; pfam04213 446469010292 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 446469010293 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 446469010294 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 446469010295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469010296 NAD(P) binding site [chemical binding]; other site 446469010297 active site 446469010298 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 446469010299 putative catalytic site [active] 446469010300 putative phosphate binding site [ion binding]; other site 446469010301 active site 446469010302 metal binding site A [ion binding]; metal-binding site 446469010303 DNA binding site [nucleotide binding] 446469010304 putative AP binding site [nucleotide binding]; other site 446469010305 putative metal binding site B [ion binding]; other site 446469010306 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446469010307 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446469010308 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446469010309 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446469010310 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469010311 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469010312 Septum formation; Region: Septum_form; pfam13845 446469010313 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469010314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469010315 DNA binding residues [nucleotide binding] 446469010316 dimerization interface [polypeptide binding]; other site 446469010317 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 446469010318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469010319 Walker A motif; other site 446469010320 ATP binding site [chemical binding]; other site 446469010321 Walker B motif; other site 446469010322 arginine finger; other site 446469010323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446469010324 Walker A motif; other site 446469010325 ATP binding site [chemical binding]; other site 446469010326 Walker B motif; other site 446469010327 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446469010328 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446469010329 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446469010330 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 446469010331 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 446469010332 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 446469010333 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 446469010334 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446469010335 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 446469010336 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 446469010337 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446469010338 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 446469010339 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 446469010340 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446469010341 trimer interface [polypeptide binding]; other site 446469010342 active site 446469010343 TM2 domain; Region: TM2; pfam05154 446469010344 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 446469010345 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446469010346 active site 446469010347 catalytic site [active] 446469010348 substrate binding site [chemical binding]; other site 446469010349 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 446469010350 Dimer interface [polypeptide binding]; other site 446469010351 BRCT sequence motif; other site 446469010352 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 446469010353 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 446469010354 putative metal binding site [ion binding]; other site 446469010355 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 446469010356 Pirin-related protein [General function prediction only]; Region: COG1741 446469010357 Pirin; Region: Pirin; pfam02678 446469010358 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 446469010359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469010360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469010361 Coenzyme A binding pocket [chemical binding]; other site 446469010362 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 446469010363 heme binding pocket [chemical binding]; other site 446469010364 heme ligand [chemical binding]; other site 446469010365 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446469010366 active site 446469010367 ATP binding site [chemical binding]; other site 446469010368 substrate binding site [chemical binding]; other site 446469010369 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446469010370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446469010371 motif II; other site 446469010372 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446469010373 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446469010374 NHL repeat; Region: NHL; pfam01436 446469010375 Strictosidine synthase; Region: Str_synth; pfam03088 446469010376 HTH domain; Region: HTH_11; cl17392 446469010377 WYL domain; Region: WYL; pfam13280 446469010378 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446469010379 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 446469010380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446469010381 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446469010382 Coenzyme A binding pocket [chemical binding]; other site 446469010383 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446469010384 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446469010385 PAS fold; Region: PAS_7; pfam12860 446469010386 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469010387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469010388 dimer interface [polypeptide binding]; other site 446469010389 phosphorylation site [posttranslational modification] 446469010390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469010391 ATP binding site [chemical binding]; other site 446469010392 Mg2+ binding site [ion binding]; other site 446469010393 G-X-G motif; other site 446469010394 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 446469010395 Copper resistance protein D; Region: CopD; cl00563 446469010396 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 446469010397 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446469010398 catalytic core [active] 446469010399 MoxR-like ATPases [General function prediction only]; Region: COG0714 446469010400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446469010401 Protein of unknown function DUF58; Region: DUF58; pfam01882 446469010402 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446469010403 von Willebrand factor type A domain; Region: VWA_2; pfam13519 446469010404 metal ion-dependent adhesion site (MIDAS); other site 446469010405 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446469010406 metal ion-dependent adhesion site (MIDAS); other site 446469010407 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 446469010408 FAD binding domain; Region: FAD_binding_4; pfam01565 446469010409 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 446469010410 Pertussis toxin, subunit 1; Region: Pertussis_S1; cl03779 446469010411 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 446469010412 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 446469010413 short chain dehydrogenase; Provisional; Region: PRK06701 446469010414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469010415 NAD(P) binding site [chemical binding]; other site 446469010416 active site 446469010417 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446469010418 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 446469010419 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446469010420 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446469010421 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446469010422 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 446469010423 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446469010424 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 446469010425 DNA binding residues [nucleotide binding] 446469010426 MerR, DNA binding; Region: MerR-DNA-bind; pfam09278 446469010427 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446469010428 E3 interaction surface; other site 446469010429 lipoyl attachment site [posttranslational modification]; other site 446469010430 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 446469010431 e3 binding domain; Region: E3_binding; pfam02817 446469010432 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446469010433 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446469010434 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446469010435 alpha subunit interface [polypeptide binding]; other site 446469010436 TPP binding site [chemical binding]; other site 446469010437 heterodimer interface [polypeptide binding]; other site 446469010438 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446469010439 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 446469010440 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446469010441 tetramer interface [polypeptide binding]; other site 446469010442 TPP-binding site [chemical binding]; other site 446469010443 heterodimer interface [polypeptide binding]; other site 446469010444 phosphorylation loop region [posttranslational modification] 446469010445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446469010446 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469010447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469010448 active site 446469010449 phosphorylation site [posttranslational modification] 446469010450 intermolecular recognition site; other site 446469010451 dimerization interface [polypeptide binding]; other site 446469010452 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469010453 DNA binding residues [nucleotide binding] 446469010454 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446469010455 Protein of unknown function (DUF805); Region: DUF805; cl01224 446469010456 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 446469010457 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 446469010458 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446469010459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469010460 homodimer interface [polypeptide binding]; other site 446469010461 catalytic residue [active] 446469010462 Predicted membrane protein [Function unknown]; Region: COG1950 446469010463 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446469010464 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446469010465 active site 446469010466 adenylosuccinate lyase; Provisional; Region: PRK09285 446469010467 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 446469010468 tetramer interface [polypeptide binding]; other site 446469010469 active site 446469010470 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 446469010471 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 446469010472 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 446469010473 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 446469010474 substrate binding site [chemical binding]; other site 446469010475 active site 446469010476 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 446469010477 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 446469010478 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 446469010479 domain interfaces; other site 446469010480 active site 446469010481 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 446469010482 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 446469010483 active site 446469010484 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 446469010485 dimer interface [polypeptide binding]; other site 446469010486 active site 446469010487 Schiff base residues; other site 446469010488 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 446469010489 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446469010490 inhibitor-cofactor binding pocket; inhibition site 446469010491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469010492 catalytic residue [active] 446469010493 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 446469010494 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446469010495 Walker A/P-loop; other site 446469010496 ATP binding site [chemical binding]; other site 446469010497 Q-loop/lid; other site 446469010498 ABC transporter signature motif; other site 446469010499 Walker B; other site 446469010500 D-loop; other site 446469010501 H-loop/switch region; other site 446469010502 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 446469010503 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 446469010504 putative homodimer interface [polypeptide binding]; other site 446469010505 putative homotetramer interface [polypeptide binding]; other site 446469010506 putative allosteric switch controlling residues; other site 446469010507 putative metal binding site [ion binding]; other site 446469010508 putative homodimer-homodimer interface [polypeptide binding]; other site 446469010509 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446469010510 metal-binding site [ion binding] 446469010511 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446469010512 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446469010513 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446469010514 metal-binding site [ion binding] 446469010515 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 446469010516 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446469010517 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446469010518 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446469010519 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446469010520 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446469010521 Walker A/P-loop; other site 446469010522 ATP binding site [chemical binding]; other site 446469010523 Q-loop/lid; other site 446469010524 ABC transporter signature motif; other site 446469010525 Walker B; other site 446469010526 D-loop; other site 446469010527 H-loop/switch region; other site 446469010528 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 446469010529 CAAX protease self-immunity; Region: Abi; pfam02517 446469010530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469010531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469010532 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 446469010533 catalytic motif [active] 446469010534 Zn binding site [ion binding]; other site 446469010535 RibD C-terminal domain; Region: RibD_C; cl17279 446469010536 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 446469010537 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 446469010538 YibE/F-like protein; Region: YibE_F; pfam07907 446469010539 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 446469010540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469010541 putative substrate translocation pore; other site 446469010542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469010543 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 446469010544 IHF dimer interface [polypeptide binding]; other site 446469010545 IHF - DNA interface [nucleotide binding]; other site 446469010546 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 446469010547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469010548 S-adenosylmethionine binding site [chemical binding]; other site 446469010549 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 446469010550 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 446469010551 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469010552 ABC-ATPase subunit interface; other site 446469010553 dimer interface [polypeptide binding]; other site 446469010554 putative PBP binding regions; other site 446469010555 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446469010556 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469010557 ABC-ATPase subunit interface; other site 446469010558 dimer interface [polypeptide binding]; other site 446469010559 putative PBP binding regions; other site 446469010560 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 446469010561 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446469010562 siderophore binding site; other site 446469010563 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 446469010564 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446469010565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446469010566 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446469010567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469010568 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446469010569 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469010570 DNA binding site [nucleotide binding] 446469010571 domain linker motif; other site 446469010572 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446469010573 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446469010574 DNA binding site [nucleotide binding] 446469010575 domain linker motif; other site 446469010576 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446469010577 dimerization interface [polypeptide binding]; other site 446469010578 ligand binding site [chemical binding]; other site 446469010579 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446469010580 active site 446469010581 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 446469010582 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 446469010583 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 446469010584 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 446469010585 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 446469010586 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 446469010587 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 446469010588 EamA-like transporter family; Region: EamA; pfam00892 446469010589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446469010590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446469010591 dimerization interface [polypeptide binding]; other site 446469010592 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 446469010593 active site 446469010594 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 446469010595 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469010596 DNA binding residues [nucleotide binding] 446469010597 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 446469010598 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446469010599 NADP binding site [chemical binding]; other site 446469010600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469010601 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446469010602 NAD(P) binding site [chemical binding]; other site 446469010603 active site 446469010604 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446469010605 peptide synthase; Provisional; Region: PRK09274 446469010606 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446469010607 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446469010608 acyl-activating enzyme (AAE) consensus motif; other site 446469010609 acyl-activating enzyme (AAE) consensus motif; other site 446469010610 AMP binding site [chemical binding]; other site 446469010611 active site 446469010612 CoA binding site [chemical binding]; other site 446469010613 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 446469010614 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446469010615 active site 446469010616 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469010617 dimer interface [polypeptide binding]; other site 446469010618 putative CheW interface [polypeptide binding]; other site 446469010619 HAMP domain; Region: HAMP; pfam00672 446469010620 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446469010621 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446469010622 dimer interface [polypeptide binding]; other site 446469010623 putative CheW interface [polypeptide binding]; other site 446469010624 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446469010625 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446469010626 hydrophobic ligand binding site; other site 446469010627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469010628 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 446469010629 NAD(P) binding site [chemical binding]; other site 446469010630 active site 446469010631 GTPase RsgA; Reviewed; Region: PRK01889 446469010632 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 446469010633 GTPase/Zn-binding domain interface [polypeptide binding]; other site 446469010634 GTP/Mg2+ binding site [chemical binding]; other site 446469010635 G4 box; other site 446469010636 G5 box; other site 446469010637 G1 box; other site 446469010638 Switch I region; other site 446469010639 G2 box; other site 446469010640 G3 box; other site 446469010641 Switch II region; other site 446469010642 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 446469010643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446469010644 dimerization interface [polypeptide binding]; other site 446469010645 putative DNA binding site [nucleotide binding]; other site 446469010646 putative Zn2+ binding site [ion binding]; other site 446469010647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469010648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469010649 H+ Antiporter protein; Region: 2A0121; TIGR00900 446469010650 Helix-turn-helix domain; Region: HTH_20; pfam12840 446469010651 dimerization interface [polypeptide binding]; other site 446469010652 putative DNA binding site [nucleotide binding]; other site 446469010653 putative Zn2+ binding site [ion binding]; other site 446469010654 MarR family; Region: MarR_2; cl17246 446469010655 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446469010656 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 446469010657 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 446469010658 DNA binding residues [nucleotide binding] 446469010659 dimer interface [polypeptide binding]; other site 446469010660 [2Fe-2S] cluster binding site [ion binding]; other site 446469010661 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446469010662 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 446469010663 intersubunit interface [polypeptide binding]; other site 446469010664 CopC domain; Region: CopC; pfam04234 446469010665 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 446469010666 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446469010667 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446469010668 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 446469010669 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446469010670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446469010671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469010672 putative PBP binding loops; other site 446469010673 dimer interface [polypeptide binding]; other site 446469010674 ABC-ATPase subunit interface; other site 446469010675 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446469010676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446469010677 dimer interface [polypeptide binding]; other site 446469010678 conserved gate region; other site 446469010679 putative PBP binding loops; other site 446469010680 ABC-ATPase subunit interface; other site 446469010681 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446469010682 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446469010683 substrate binding pocket [chemical binding]; other site 446469010684 membrane-bound complex binding site; other site 446469010685 hinge residues; other site 446469010686 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446469010687 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446469010688 Walker A/P-loop; other site 446469010689 ATP binding site [chemical binding]; other site 446469010690 Q-loop/lid; other site 446469010691 ABC transporter signature motif; other site 446469010692 Walker B; other site 446469010693 D-loop; other site 446469010694 H-loop/switch region; other site 446469010695 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446469010696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469010697 NAD(P) binding site [chemical binding]; other site 446469010698 active site 446469010699 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 446469010700 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446469010701 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446469010702 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469010703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469010704 active site 446469010705 phosphorylation site [posttranslational modification] 446469010706 intermolecular recognition site; other site 446469010707 dimerization interface [polypeptide binding]; other site 446469010708 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469010709 DNA binding residues [nucleotide binding] 446469010710 dimerization interface [polypeptide binding]; other site 446469010711 Histidine kinase; Region: HisKA_3; pfam07730 446469010712 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446469010713 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446469010714 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446469010715 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446469010716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469010717 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446469010718 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 446469010719 FMN binding site [chemical binding]; other site 446469010720 active site 446469010721 substrate binding site [chemical binding]; other site 446469010722 catalytic residue [active] 446469010723 short chain dehydrogenase; Validated; Region: PRK08264 446469010724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469010725 NAD(P) binding site [chemical binding]; other site 446469010726 active site 446469010727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469010728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469010729 WHG domain; Region: WHG; pfam13305 446469010730 short chain dehydrogenase; Validated; Region: PRK06182 446469010731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469010732 NAD(P) binding site [chemical binding]; other site 446469010733 active site 446469010734 short chain dehydrogenase; Validated; Region: PRK08264 446469010735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446469010736 NAD(P) binding site [chemical binding]; other site 446469010737 active site 446469010738 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446469010739 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446469010740 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446469010741 putative NAD(P) binding site [chemical binding]; other site 446469010742 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446469010743 TAP-like protein; Region: Abhydrolase_4; pfam08386 446469010744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469010745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469010746 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 446469010747 gamma subunit interface [polypeptide binding]; other site 446469010748 epsilon subunit interface [polypeptide binding]; other site 446469010749 LBP interface [polypeptide binding]; other site 446469010750 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 446469010751 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 446469010752 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446469010753 TAP-like protein; Region: Abhydrolase_4; pfam08386 446469010754 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 446469010755 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 446469010756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446469010757 TPR motif; other site 446469010758 binding surface 446469010759 TPR repeat; Region: TPR_11; pfam13414 446469010760 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 446469010761 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446469010762 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446469010763 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 446469010764 active site 446469010765 homotetramer interface [polypeptide binding]; other site 446469010766 homodimer interface [polypeptide binding]; other site 446469010767 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 446469010768 substrate binding site [chemical binding]; other site 446469010769 THF binding site; other site 446469010770 zinc-binding site [ion binding]; other site 446469010771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446469010772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446469010773 MMPL family; Region: MMPL; pfam03176 446469010774 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446469010775 Cation efflux family; Region: Cation_efflux; cl00316 446469010776 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 446469010777 nudix motif; other site 446469010778 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446469010779 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 446469010780 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 446469010781 Predicted membrane protein [Function unknown]; Region: COG3371 446469010782 Protein of unknown function (DUF998); Region: DUF998; pfam06197 446469010783 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446469010784 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446469010785 Walker A/P-loop; other site 446469010786 ATP binding site [chemical binding]; other site 446469010787 Q-loop/lid; other site 446469010788 ABC transporter signature motif; other site 446469010789 Walker B; other site 446469010790 D-loop; other site 446469010791 H-loop/switch region; other site 446469010792 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 446469010793 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469010794 ABC-ATPase subunit interface; other site 446469010795 dimer interface [polypeptide binding]; other site 446469010796 putative PBP binding regions; other site 446469010797 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446469010798 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446469010799 ABC-ATPase subunit interface; other site 446469010800 dimer interface [polypeptide binding]; other site 446469010801 putative PBP binding regions; other site 446469010802 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446469010803 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446469010804 FAD binding pocket [chemical binding]; other site 446469010805 FAD binding motif [chemical binding]; other site 446469010806 phosphate binding motif [ion binding]; other site 446469010807 NAD binding pocket [chemical binding]; other site 446469010808 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446469010809 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446469010810 intersubunit interface [polypeptide binding]; other site 446469010811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446469010812 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446469010813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446469010814 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446469010815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469010816 Q-loop/lid; other site 446469010817 ABC transporter signature motif; other site 446469010818 Walker B; other site 446469010819 D-loop; other site 446469010820 H-loop/switch region; other site 446469010821 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446469010822 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446469010823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446469010824 Walker A/P-loop; other site 446469010825 ATP binding site [chemical binding]; other site 446469010826 Q-loop/lid; other site 446469010827 ABC transporter signature motif; other site 446469010828 Walker B; other site 446469010829 D-loop; other site 446469010830 H-loop/switch region; other site 446469010831 MarR family; Region: MarR; pfam01047 446469010832 CsbD-like; Region: CsbD; pfam05532 446469010833 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 446469010834 putative substrate binding pocket [chemical binding]; other site 446469010835 AC domain interface; other site 446469010836 catalytic triad [active] 446469010837 AB domain interface; other site 446469010838 interchain disulfide; other site 446469010839 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446469010840 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446469010841 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446469010842 Phosphotransferase enzyme family; Region: APH; pfam01636 446469010843 active site 446469010844 ATP binding site [chemical binding]; other site 446469010845 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446469010846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446469010847 putative substrate translocation pore; other site 446469010848 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446469010849 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446469010850 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446469010851 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446469010852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446469010853 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 446469010854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446469010855 dimer interface [polypeptide binding]; other site 446469010856 phosphorylation site [posttranslational modification] 446469010857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446469010858 ATP binding site [chemical binding]; other site 446469010859 Mg2+ binding site [ion binding]; other site 446469010860 G-X-G motif; other site 446469010861 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446469010862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469010863 active site 446469010864 phosphorylation site [posttranslational modification] 446469010865 intermolecular recognition site; other site 446469010866 dimerization interface [polypeptide binding]; other site 446469010867 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446469010868 DNA binding site [nucleotide binding] 446469010869 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 446469010870 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446469010871 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446469010872 RRNA methyltransferase AviRa; Region: AviRa; pfam11599 446469010873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446469010874 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 446469010875 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 446469010876 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 446469010877 putative metal binding site [ion binding]; other site 446469010878 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 446469010879 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 446469010880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446469010881 ABC-ATPase subunit interface; other site 446469010882 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 446469010883 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 446469010884 Walker A/P-loop; other site 446469010885 ATP binding site [chemical binding]; other site 446469010886 Q-loop/lid; other site 446469010887 ABC transporter signature motif; other site 446469010888 Walker B; other site 446469010889 D-loop; other site 446469010890 H-loop/switch region; other site 446469010891 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446469010892 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 446469010893 putative acyl-acceptor binding pocket; other site 446469010894 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 446469010895 AAA domain; Region: AAA_17; pfam13207 446469010896 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 446469010897 active site 446469010898 metal binding site [ion binding]; metal-binding site 446469010899 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 446469010900 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 446469010901 Methyltransferase domain; Region: Methyltransf_12; pfam08242 446469010902 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 446469010903 active site 446469010904 NTP binding site [chemical binding]; other site 446469010905 metal binding triad [ion binding]; metal-binding site 446469010906 S-formylglutathione hydrolase; Region: PLN02442 446469010907 Putative esterase; Region: Esterase; pfam00756 446469010908 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 446469010909 dimer interface [polypeptide binding]; other site 446469010910 pyridoxal binding site [chemical binding]; other site 446469010911 ATP binding site [chemical binding]; other site 446469010912 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 446469010913 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 446469010914 active site 446469010915 metal binding site [ion binding]; metal-binding site 446469010916 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446469010917 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 446469010918 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 446469010919 glutaminase; Reviewed; Region: PRK12356 446469010920 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 446469010921 replicative DNA helicase; Region: DnaB; TIGR00665 446469010922 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446469010923 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 446469010924 Walker A motif; other site 446469010925 ATP binding site [chemical binding]; other site 446469010926 Walker B motif; other site 446469010927 DNA binding loops [nucleotide binding] 446469010928 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 446469010929 putative efflux protein, MATE family; Region: matE; TIGR00797 446469010930 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446469010931 Beta-lactamase; Region: Beta-lactamase; pfam00144 446469010932 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 446469010933 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 446469010934 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 446469010935 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 446469010936 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 446469010937 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446469010938 dimer interface [polypeptide binding]; other site 446469010939 ssDNA binding site [nucleotide binding]; other site 446469010940 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446469010941 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 446469010942 Transglycosylase; Region: Transgly; pfam00912 446469010943 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446469010944 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446469010945 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446469010946 Predicted transcriptional regulators [Transcription]; Region: COG1695 446469010947 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446469010948 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 446469010949 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 446469010950 H+ Antiporter protein; Region: 2A0121; TIGR00900 446469010951 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446469010952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446469010953 active site 446469010954 phosphorylation site [posttranslational modification] 446469010955 intermolecular recognition site; other site 446469010956 dimerization interface [polypeptide binding]; other site 446469010957 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446469010958 DNA binding residues [nucleotide binding] 446469010959 dimerization interface [polypeptide binding]; other site 446469010960 Histidine kinase; Region: HisKA_3; pfam07730 446469010961 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446469010962 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 446469010963 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 446469010964 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 446469010965 active site 446469010966 NTP binding site [chemical binding]; other site 446469010967 metal binding triad [ion binding]; metal-binding site 446469010968 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 446469010969 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446469010970 Zn2+ binding site [ion binding]; other site 446469010971 Mg2+ binding site [ion binding]; other site 446469010972 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 446469010973 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 446469010974 active site 446469010975 Ap6A binding site [chemical binding]; other site 446469010976 nudix motif; other site 446469010977 metal binding site [ion binding]; metal-binding site 446469010978 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 446469010979 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 446469010980 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 446469010981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446469010982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446469010983 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446469010984 catalytic residues [active] 446469010985 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 446469010986 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446469010987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446469010988 homodimer interface [polypeptide binding]; other site 446469010989 catalytic residue [active] 446469010990 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 446469010991 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446469010992 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446469010993 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 446469010994 ParB-like nuclease domain; Region: ParBc; pfam02195 446469010995 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446469010996 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446469010997 P-loop; other site 446469010998 Magnesium ion binding site [ion binding]; other site 446469010999 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446469011000 Magnesium ion binding site [ion binding]; other site 446469011001 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446469011002 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 446469011003 Putative methyltransferase; Region: Methyltransf_16; pfam10294 446469011004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446469011005 S-adenosylmethionine binding site [chemical binding]; other site 446469011006 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 446469011007 G-X-X-G motif; other site 446469011008 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 446469011009 RxxxH motif; other site 446469011010 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 446469011011 Haemolytic domain; Region: Haemolytic; pfam01809 446469011012 Ribonuclease P; Region: Ribonuclease_P; pfam00825 446469011013 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399